KEVZARA庐 (sarilumab) for Polymyalgia Rheumatica (PMR) | KEVZARA (sarilumab) injection 200 mg

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KEVZARA has not been investigated in combination with JAK inhibitors or biological DMARDs such as TNF antagonists [see Dosage and Administration (2.2)]. 7.2 Interactions with CYP450 Substrates Various in vitro and limited in vivo human studies have shown that cytokines and cytokine modulators can influence the expression and activity of specific cytochrome P450 (CYP) enzymes and therefore have the potential to alter the pharmacokinetics of concomitantly administered drugs that are substrates of these enzymes. Elevated interleukin-6 (IL-6) concentration may down-regulate CYP activity. Blockade of IL-6 signaling by IL-6R伪 antagonists such as KEVZARA might reverse the inhibitory effect of IL-6 and restore CYP activity, leading to altered drug concentrations. The modulation of IL-6 effect on CYP enzymes by KEVZARA may be clinically relevant for CYP substrates with a narrow therapeutic index, where the dose is individually adjusted. Upon initiation or discontinuation of KEVZARA, in patients being treated with CYP substrate medicinal products, perform therapeutic monitoring of effect (e.g., warfarin) or drug concentration (e.g., theophylline) and adjust the individual dose of the medicinal product as needed. Exercise caution when co-administering KEVZARA with CYP3A4 substrate drugs where decrease in effectiveness is undesirable, e.g., oral contraceptives, lovastatin, atorvastatin, etc. The effect of KEVZARA on CYP450 enzyme activity may persist for several weeks after stopping therapy [see Clinical Pharmacology (12.3)].", "doseSchedule": { "@type": "DoseSchedule", "doseUnit": "", "doseValue": "", "frequency": "The recommended dosage of KEVZARA is 200 mg once every two weeks given as a subcutaneous injection, in combination with a tapering course of systemic corticosteroids [see Dosage and Administration (2.1)]. KEVZARA can be used as monotherapy following discontinuation of corticosteroids. Discontinue KEVZARA if the patient develops neutropenia (using ANC results obtained at the end of the dosing interval), thrombocytopenia, or liver enzyme abnormalities [see Dosage and Administration (2.5), Warnings and Precautions (5.2) and Adverse Reactions (6.1)].", "targetPopulation": "Adults" }, "labelDetails": "https://products.sanofi.us/Kevzara/Kevzara.pdf", "mechanismOfAction": "Sarilumab binds to both soluble and membrane-bound IL-6 receptors (sIL-6R and mIL-6R), and has been shown to inhibit IL-6-mediated signaling through these receptors. IL-6 is a pleiotropic pro-inflammatory cytokine produced by a variety of cell types including T- and B-cells, lymphocytes, monocytes, and fibroblasts. IL-6 has been shown to be involved in diverse physiological processes such as T-cell activation, induction of immunoglobulin secretion, initiation of hepatic acute phase protein synthesis, and stimulation of hematopoietic precursor cell proliferation and differentiation. IL-6 is also produced by synovial and endothelial cells leading to local production. ", "prescriptionStatus": "https://health-lifesci.schema.org/PrescriptionOnly", "prescribingInfo": "https://products.sanofi.us/Kevzara/Kevzara.pdf", "foodWarning": "", "alcoholWarning": "", "breastfeedingWarning" : "No information is available on the presence of sarilumab in human milk, the effects of the drug on the breastfed infant, or the effects of the drug on milk production. Maternal IgG is present in human milk. If sarilumab is transferred into human milk, the effects of local exposure in the gastrointestinal tract and potential limited systemic exposure in the infant to sarilumab are unknown. The lack of clinical data during lactation precludes clear determination of the risk of KEVZARA to an infant during lactation; therefore, the developmental and health benefits of breastfeeding should be considered along with the mother鈥檚 clinical need for KEVZARA and the potential adverse effects on the breastfed child from KEVZARA or from the underlying maternal condition.", "pregnancyWarning": "The limited human data with KEVZARA in pregnant women are not sufficient to inform drug- associated risk for major birth defects and miscarriage. Monoclonal antibodies, such as sarilumab, are actively transported across the placenta during the third trimester of pregnancy and may affect immune response in the in utero exposed infant (see Clinical Considerations). From animal data, and consistent with the mechanism of action, levels of IgG, in response to antigen challenge, may be reduced in the fetus/infant of treated mothers (see Clinical Considerations and Data). In an animal reproduction study, consisting of a combined embryo-fetal and pre- and postnatal development study with monkeys that received intravenous administration of sarilumab, there was no evidence of embryotoxicity or fetal malformations with exposures up to approximately 84 times the maximum recommended human dose (MRHD) (see Data). The literature suggests that inhibition of IL-6 signaling may interfere with cervical ripening and dilatation and myometrial contractile activity leading to potential delays of parturition (see Data). The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the US general population, the estimated background risk of major birth defects and miscarriages in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively. KEVZARA should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. " }, "about": { "@type": "MedicalCondition", "name": "Polymyalgia rheumatica (PMR) for Patients ", "sameAs": "", "relevantSpecialty": "https://health-lifesci.schema.org/Rheumatologic", "alternateName": "", "signOrSymptom": [ { "@type": "MedicalSymptom", "name": "Inflammation" }, { "@type": "MedicalSymptom", "name": "stiffness" }], "associatedAnatomy": { "@type": "AnatomicalSystem", "name": "" }, "possibleTreatment": { "@type": "MedicalTherapy", "name": "KEVZARA庐 (sarilumab)" } } } </script> </head> <body class=" relative right-0 transition-all duration-300 ease-in-out flex flex-col !min-h-screen"> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-547QWVDV" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <a href="#main" class="skipToMainContent skip font-body bg-primary2 text-white fixed top-0 left-0 z-0 opacity-0 focus:z-40 focus:opacity-100 px-5 py-3">Skip to main content</a> <div x-data="stickyHeader" @resize.window.throttle="setHeaderTop" class="endorsementBar bg-tertiary2 z-30 top-0 border-b-2 lg:border-b-0 block relative lg:relative"> <div class="container lg:px-1 w-full flex justify-between items-center content-center p-4" x-data=""> <p class="text-black visible md:visible lg:visible font-body text-xs pr-4">Site intended for U.S. Residents only</p> </div> </div> <header class="z-40 sticky top-0 lg:top-0" role="banner"> <div class="baseHeader z-30 relative max-w-full mx-auto bg-white "> <div class="header__content container mx-auto py-0 md:py-0 lg:py-0 px-4 md:px-8 lg:px-8"> <div> <div class="flex justify-between w-full"> <div class="w-3/12 md:w-3/12 lg:w-2/12 lg:flex-grow-0"> <div class="header__logo flex h-full"> <div class="self-auto md:self-auto lg:self-auto"> <div class="header__logo flex flex-grow-0 items-center"> <div class="py-2"> <a href="/pmr/" data-gtmSection="header" data-gtmSubSection="logo" data-gtmElement="logo"> <img src="/dam/jcr:a55db5ea-aad4-4764-8ef1-7a852cddbc74/logo-kevzara-200-mg-injection.svg" alt="KEVZARA (sarilumab) 200 mg injection logo" class="max-w-xs w-full block" /> </a> </div> </div> </div> </div> </div> <div class="header__main px-4 hidden flex-col lg:flex flex-grow justify-center md:justify-center lg:justify-center w-2/12 md:w-6/12 lg:w-5/12 "> <div class=" text-body-5 py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 bg-transparent"> <ul class="headerContent flex justify-center md:justify-center lg:justify-evenly items-center md:items-end lg:items-end bg-transparent hover:bg-transparent "> <li> <div class="flex flex-row px-2 py-2 items-center md:items-end lg:items-end w-auto md:w-auto lg:w-auto"> <a href="#in-page-isi" target="_self" title="Important Safety Information" data-gtmSection="" data-gtmSubSection="" data-gtmElement="" class="font-title cursor-pointer inline font-navigation text-primary1 hover:text-default " > <span > Important Safety Information </span> </a> </div> </li> <li> <div class="flex flex-row px-2 py-2 items-center md:items-end lg:items-end w-auto md:w-auto lg:w-auto"> <a href="https://products.sanofi.us/Kevzara/Kevzara.pdf" rel='noopener' target="_blank" title=" Prescribing Information" data-gtmSection="" data-gtmSubSection="" data-gtmElement="" class="font-title cursor-pointer inline font-navigation text-primary1 hover:text-default " > <span > Prescribing Information </span> </a> </div> </li> <li> <div class="flex flex-row px-2 py-2 items-center md:items-end lg:items-end w-auto md:w-auto lg:w-auto"> <a href="https://products.sanofi.us/kevzara/kevzara_medguide.pdf" rel='noopener' target="_blank" title="Medication Guide/IFU" data-gtmSection="" data-gtmSubSection="" data-gtmElement="" class="font-title cursor-pointer inline font-navigation text-primary1 hover:text-default " > <span > Medication Guide/IFU </span> </a> </div> </li> </ul> </div> </div> <div class="header__util w-1/2 lg:w-auto lg:flex-grow-0 flex flex-col justify-center md:justify-center lg:justify-center w-2/12 md:w-3/12 lg:w-6/12"> <div class="lg:hidden py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 bg-transparent"> <ul class="headerContent flex justify-end md:justify-end lg:justify-start items-end md:items-end lg:items-end bg-transparent hover:bg-transparent "> <li> <div class="items-end md:items-end lg:items-end text-primary1 hover:text-primary1"> <button aria-label="open menu" x-data="{menuOpen: false}" @click.prevent="menuOpen = !menuOpen; 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hover:text-primary1 bg-white bg-opacity-20 sr-only" x-bind="mainLi" :class="{'sr-only': !srVisible}" > <button class="block w-full text-left" x-bind="skipButton" data-target-id="navlink-3ce91be2-1988-47e8-be2d-4a2327386f35" > <div class="px-4 py-2 border-primary3 border-b"> 1 Staying on KEVZARA </div> </button> </li> <li class="lg:hover:bg-primary2 hover:text-primary1 border-primary3 border-b" > <a href="/pmr/starting-kevzara/how-does-kevzara-work" class="block px-4 py-2" x-ref="" data-gtmSection="header" data-gtmSubSection="menu" x-bind="childLink" > How does KEVZARA work? </a> </li> <li class="lg:hover:bg-primary2 hover:text-primary1 border-primary3 border-b" > <a href="/pmr/starting-kevzara/how-kevzara-may-help" class="block px-4 py-2" x-ref="" data-gtmSection="header" data-gtmSubSection="menu" x-bind="childLink" > How KEVZARA may help </a> </li> <li class="lg:hover:bg-primary2 hover:text-primary1 border-primary3 border-b" > <a href="/pmr/starting-kevzara/possible-side-effects" class="block px-4 py-2" x-ref="" data-gtmSection="header" data-gtmSubSection="menu" x-bind="childLink" > Possible side effects with KEVZARA </a> </li> <li class="lg:hover:bg-primary2 hover:text-primary1 border-primary3 border-b" > <a href="/pmr/starting-kevzara/how-to-take-kevzara" class="block px-4 py-2" x-ref="" data-gtmSection="header" data-gtmSubSection="menu" x-bind="childLink" > How to take KEVZARA </a> </li> </ul> </li> <li class="mainLi font-navigation relative text-white lg:hover:text-primary1 lg:hover:bg-primary2" data-navlinkId="navlink-3ce91be2-1988-47e8-be2d-4a2327386f35" data-hasChildren="true" x-bind="mainLi" > <button id="navlink-3ce91be2-1988-47e8-be2d-4a2327386f35" class=" flex justify-between lg:block py-3 px-4 w-full relative" data-hasChildren="true"> Staying on KEVZARA <div class="inline ml-1"> <svg class="w-4 h-4 hidden lg:inline fill-current" aria-hidden="false" role="img"> <use xlink:href="/.resources/sanofi-lm-platform/themes/sanofi-platform/src/img/sprites/solid.svg#angle-down"></use> </svg> <div class="lg:hidden rtl:pl-6 ltr:pr-6"> <div :class="{'hidden': activeNavlink != 'navlink-3ce91be2-1988-47e8-be2d-4a2327386f35'}"> <svg class="w-4 h-4 inline fill-current" aria-hidden="false" role="img"> <use xlink:href="/.resources/sanofi-lm-platform/themes/sanofi-platform/src/img/sprites/solid.svg#angle-up"></use> </svg> </div> <div :class="{'hidden': activeNavlink == 'navlink-3ce91be2-1988-47e8-be2d-4a2327386f35'}"> <svg class="w-4 h-4 inline fill-current" aria-hidden="false" role="img"> <use xlink:href="/.resources/sanofi-lm-platform/themes/sanofi-platform/src/img/sprites/solid.svg#angle-down"></use> </svg> </div> </div> </div> </button> <ul class="z-30 lg:absolute lg:left-0 lg:top-full hidden w-full text-primary3 bg-secondary1" x-bind:class="{'hidden': activeNavlink != 'navlink-3ce91be2-1988-47e8-be2d-4a2327386f35'}" > <li class="lg:hover:bg-primary2 hover:text-primary1 bg-white bg-opacity-20 sr-only" x-bind="mainLi" :class="{'sr-only': !srVisible}" > <button class="block w-full text-left" x-bind="skipButton" data-target-id="navlink-90808f89-5977-4ab9-99d6-69d82c3a9228" > <div class="px-4 py-2 border-primary3 border-b"> 1 Resources for You </div> </button> </li> <li class="lg:hover:bg-primary2 hover:text-primary1 border-primary3 border-b" > <a href="/pmr/staying-on-kevzara/managing-treatment-at-home" class="block px-4 py-2" x-ref="" data-gtmSection="header" data-gtmSubSection="menu" x-bind="childLink" > Managing treatment at home </a> </li> <li class="lg:hover:bg-primary2 hover:text-primary1 border-primary3 border-b" > <a href="/pmr/staying-on-kevzara/building-your-support-team" class="block px-4 py-2" x-ref="" data-gtmSection="header" data-gtmSubSection="menu" x-bind="childLink" > Building your support team </a> </li> <li class="lg:hover:bg-primary2 hover:text-primary1 border-primary3 border-b" > <a href="/pmr/staying-on-kevzara/for-caregivers" class="block px-4 py-2" x-ref="" data-gtmSection="header" data-gtmSubSection="menu" x-bind="childLink" > For caregivers </a> </li> <li class="lg:hover:bg-primary2 hover:text-primary1 border-primary3 border-b" > <a href="/pmr/staying-on-kevzara/traveling-with-kevzara" class="block px-4 py-2" x-ref="" data-gtmSection="header" data-gtmSubSection="menu" x-bind="childLink" > Traveling with KEVZARA </a> </li> </ul> </li> <li class="mainLi font-navigation relative text-white lg:hover:text-primary1 lg:hover:bg-primary2" data-navlinkId="navlink-90808f89-5977-4ab9-99d6-69d82c3a9228" data-hasChildren="true" x-bind="mainLi" > <button id="navlink-90808f89-5977-4ab9-99d6-69d82c3a9228" class=" flex justify-between lg:block py-3 px-4 w-full relative" data-hasChildren="true"> Resources for You <div class="inline ml-1"> <svg class="w-4 h-4 hidden lg:inline fill-current" aria-hidden="false" role="img"> <use xlink:href="/.resources/sanofi-lm-platform/themes/sanofi-platform/src/img/sprites/solid.svg#angle-down"></use> </svg> <div class="lg:hidden rtl:pl-6 ltr:pr-6"> <div :class="{'hidden': activeNavlink != 'navlink-90808f89-5977-4ab9-99d6-69d82c3a9228'}"> <svg class="w-4 h-4 inline fill-current" aria-hidden="false" role="img"> <use xlink:href="/.resources/sanofi-lm-platform/themes/sanofi-platform/src/img/sprites/solid.svg#angle-up"></use> </svg> </div> <div :class="{'hidden': activeNavlink == 'navlink-90808f89-5977-4ab9-99d6-69d82c3a9228'}"> <svg class="w-4 h-4 inline fill-current" aria-hidden="false" role="img"> <use xlink:href="/.resources/sanofi-lm-platform/themes/sanofi-platform/src/img/sprites/solid.svg#angle-down"></use> </svg> </div> </div> </div> </button> <ul class="z-30 lg:absolute lg:left-0 lg:top-full hidden w-full text-primary3 bg-secondary1" x-bind:class="{'hidden': activeNavlink != 'navlink-90808f89-5977-4ab9-99d6-69d82c3a9228'}" > <li class="lg:hover:bg-primary2 hover:text-primary1 bg-white bg-opacity-20 sr-only" x-bind="mainLi" :class="{'sr-only': !srVisible}" > <button class="block w-full text-left" x-bind="skipButton" data-target-id="exit" > <div class="px-4 py-2 border-primary3 border-b"> 1 1 </div> </button> </li> <li class="lg:hover:bg-primary2 hover:text-primary1 border-primary3 border-b" > <a href="/pmr/resources/kevzaraconnect-copay-card" class="block px-4 py-2" x-ref="" data-gtmSection="header" data-gtmSubSection="menu" x-bind="childLink" > KevzaraConnect庐 Copay Card </a> </li> <li class="lg:hover:bg-primary2 hover:text-primary1 border-primary3 border-b" > <a href="/pmr/resources/how-to-get-kevzara" class="block px-4 py-2" x-ref="" data-gtmSection="header" data-gtmSubSection="menu" x-bind="childLink" > How to get KEVZARA </a> </li> <li class="lg:hover:bg-primary2 hover:text-primary1 border-primary3 border-b" > <a href="/pmr/resources/resource-library" class="block px-4 py-2" x-ref="" data-gtmSection="header" data-gtmSubSection="menu" x-bind="childLink" > Resource library </a> </li> <li class="lg:hover:bg-primary2 hover:text-primary1 border-primary3 border-b" > <a href="/pmr/resources/kevzara-faqs" class="block px-4 py-2" x-ref="" data-gtmSection="header" data-gtmSubSection="menu" x-bind="childLink" > FAQs </a> </li> <li class="lg:hover:bg-primary2 hover:text-primary1 border-primary3 border-b" > <a href="/pmr/resources/stay-connected" class="block px-4 py-2" x-ref="" data-gtmSection="header" data-gtmSubSection="menu" x-bind="childLink" > Stay connected </a> </li> </ul> </li> </ul> </div> </div> </div> <div class="lg:hidden text-body-4 py-0 md:py-0 lg:py-0 px-4 md:px-8 lg:px-0 bg-primary1"> <ul class="headerContent flex justify-start md:justify-start lg:justify-center items-center md:items-center lg:items-center bg-primary1 hover:bg-primary1 "> <li> <div class="flex flex-row px-2 py-2 items-center md:items-center lg:items-center w-auto md:w-auto lg:w-auto"> <a href="#in-page-isi" target="_self" title="" data-gtmSection="" data-gtmSubSection="" data-gtmElement="" class="font-title cursor-pointer inline font-navigation text-white hover:text-primary2 " > <span > Important Safety Information </span> </a> </div> </li> <li> <div class="flex flex-row px-2 py-2 items-center md:items-center lg:items-center w-auto md:w-auto lg:w-auto"> <a href="https://products.sanofi.us/Kevzara/Kevzara.pdf" rel='noopener' target="_blank" title="" data-gtmSection="" data-gtmSubSection="" data-gtmElement="" class="font-title cursor-pointer inline font-navigation text-white hover:text-primary2 " > <span > Prescribing Information </span> </a> </div> </li> <li> <div class="flex flex-row px-2 py-2 items-center md:items-center lg:items-center w-auto md:w-auto lg:w-auto"> <a href="https://products.sanofi.us/kevzara/kevzara_medguide.pdf" rel='noopener' target="_blank" title="" data-gtmSection="" data-gtmSubSection="" data-gtmElement="" class="font-title cursor-pointer inline font-navigation text-white hover:text-primary2 " > <span > Medication Guide/IFU </span> </a> </div> </li> </ul> </div> <div class="lg:hidden text-body-5 py-0 md:py-0 lg:py-0 px-4 md:px-8 lg:px-0 bg-white"> <ul class="headerContent flex justify-start md:justify-start lg:justify-start items-center md:items-center lg:items-center bg-white hover:bg-transparent "> <li> <div class="flex flex-row px-2 py-2 items-center md:items-center lg:items-center w-auto md:w-auto lg:w-auto"> <div x-data="{id: 'HCP'}" > <div title="" data-gtmSection="" data-gtmSubSection="" data-gtmElement="" class="font-title cursor-pointer inline font-navigation text-primary3 hover:text-primary3 " @click.stop="$dispatch('open-modal', {id})" > <span > Healthcare Professionals Site </span> </div> </div> </div> </li> <li> <div class=""> <a href="/pmr/search-page"> <svg class="w-5 h-5 fill-current mx-1 text-primary1 block fill-current" aria-hidden="false" role="img"> <use xlink:href="/.resources/sanofi-lm-platform/themes/sanofi-platform/src/img/sprites/global.svg#search-thin"></use> </svg> </a> </div> </li> </ul> </div> </div> </header> <section id="25cbd79a-954c-4db9-9e44-69e7fa426dbf" class="contentGridItem--25cbd79a-954c-4db9-9e44-69e7fa426dbf contentGridItem relative h-full " > <div x-data='anchorMenu()' class="h-full" x-intersect.margin.-50%='setActiveLinkByID("25cbd79a-954c-4db9-9e44-69e7fa426dbf");'> <div class="contentGridItem__container relative h-full" dir="ltr"> <div class="background--25cbd79a-954c-4db9-9e44-69e7fa426dbf py-0 text-primary h-full animateImage default relative z-10"> <div class="ContentGrid container mx-auto lg:pt-0 lg:pb-0 md:pt-0 md:pb-0 pt-0 pb-0"> <div class="flex md:flex md:flex-row lg:flex-row flex-wrap justify-center items-center -mx-0 py-0 md:-mx-0 md:py-0 lg:-mx-0 lg:py-0"> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full md:w-full lg:w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 items-start self-auto bg-transparent" x-data="" dir="ltr"> <section id="69fbc7b3-d3d9-47dd-af80-527da7c3edb3" class="contentGridItem--69fbc7b3-d3d9-47dd-af80-527da7c3edb3 contentGridItem relative h-full " > <div x-data='anchorMenu()' class="h-full" x-intersect.margin.-50%='setActiveLinkByID("69fbc7b3-d3d9-47dd-af80-527da7c3edb3");'> <div class="contentGridItem__container relative h-full" dir="ltr"> <div class="background--69fbc7b3-d3d9-47dd-af80-527da7c3edb3 py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 text-primary h-full animateImage bg-cover md:bg-cover bg-left-top lg:bg-top bg-no-repeat lg:bg-no-repeat bg-transparent relative z-10 lazyload" data-bgset="/dam/jcr:8e2c02a7-b4ef-4abf-baa5-60d9731c2ce7/woman-dancing-in-living-room.svg [(max-width: 767px)] | /dam/jcr:dd3a09a9-db49-4b87-9281-e171123b705b/woman-dancing-in-living-room.png" data-sizes="auto" > <div class="ContentGrid container mx-auto "> <div class="flex md:flex md:flex-row lg:flex-row flex-wrap justify-start items-start -mx-0 py-0 md:-mx-0 md:py-0 lg:-mx-0 lg:py-0"> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full md:w-9/12 lg:w-8/12 self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 items-center self-auto bg-transparent" x-data="" dir="ltr"> <section id="adbb4759-bd4e-4330-87ca-06a885ca7197" class="contentGridItem--adbb4759-bd4e-4330-87ca-06a885ca7197 contentGridItem relative h-full " > <div x-data='anchorMenu()' class="h-full" x-intersect.margin.-50%='setActiveLinkByID("adbb4759-bd4e-4330-87ca-06a885ca7197");'> <div class="contentGridItem__container relative h-full" dir="ltr"> <div class="background--adbb4759-bd4e-4330-87ca-06a885ca7197 py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 text-primary h-full animateImage bg-transparent relative z-10"> <div class="ContentGrid container mx-auto "> <div class="flex md:flex md:flex-row lg:flex-row flex-wrap justify-start items-center -mx-0 py-0 md:-mx-0 md:py-0 lg:-mx-0 lg:py-0"> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full md:w-full lg:w-9/12 self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 items-center self-auto bg-transparent" x-data="" dir="ltr"> <section id="28f877f3-e6f8-4c0d-99e9-dd9f30d9a876" class="contentGridItem--28f877f3-e6f8-4c0d-99e9-dd9f30d9a876 contentGridItem relative h-full " > <div x-data='anchorMenu()' class="h-full" x-intersect.margin.-50%='setActiveLinkByID("28f877f3-e6f8-4c0d-99e9-dd9f30d9a876");'> <div class="contentGridItem__container relative h-full" dir="ltr"> <div class="background--28f877f3-e6f8-4c0d-99e9-dd9f30d9a876 py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 text-primary h-full animateImage bg-transparent relative z-10"> <div class="ContentGrid container mx-auto "> <div class="flex md:flex md:flex-row lg:flex-row flex-wrap justify-start items-center -mx-0 py-0 md:-mx-0 md:py-0 lg:-mx-0 lg:py-0"> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full lg:w-9/12 self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-8 lg:py-4 px-4 md:px-8 lg:px-8 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p><a href="." style="line-height:19px !important; pointer-events:none;"><strong><span class="text-body-4"><span class="text-white">For adults with polymyalgia rheumatica (PMR) after corticosteroids (steroids) have been used and did not work well or when a slow decrease in the dose of corticosteroids (taper) cannot be tolerated.</span></span></strong></a></p> </div> </div> </div> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full lg:w-9/12 self-auto " > <div style="" class="ContentSectionItem h-full w-full py-8 md:py-0 lg:py-0 px-4 md:px-8 lg:px-0 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> </div> </div> </div> </div> <div class=""></div> </div> </div> </div> </section> </div> </div> </div> </div> <div class=""></div> </div> </div> </div> </section> </div> </div> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-8 md:py-0 lg:py-8 px-0 md:px-0 lg:px-0 self-auto bg-transparent" x-data="" dir="ltr"> <section id="318cafa7-c43c-4625-a54c-151d148ad9f7" class="contentGridItem--318cafa7-c43c-4625-a54c-151d148ad9f7 contentGridItem relative h-full " > <div x-data='anchorMenu()' class="h-full" x-intersect.margin.-50%='setActiveLinkByID("318cafa7-c43c-4625-a54c-151d148ad9f7");'> <div class="contentGridItem__container relative h-full" dir="ltr"> <div class="background--318cafa7-c43c-4625-a54c-151d148ad9f7 py-8 md:py-0 lg:py-8 px-0 md:px-0 lg:px-0 text-primary h-full animateImage bg-transparent relative z-10"> <div class="ContentGrid container max-w-full mx-auto "> <div class="flex md:flex lg:flex-row flex-wrap -mx-0 py-0 md:-mx-0 md:py-0 lg:-mx-1 lg:py-1"> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-1 lg:px-1 w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-16 md:py-8 lg:py-8 px-0 md:px-0 lg:px-0 self-auto bg-transparent" x-data="" dir="ltr"> <section id="73aeec65-8c73-44d3-a986-e1486d49d72c" class="contentGridItem--73aeec65-8c73-44d3-a986-e1486d49d72c contentGridItem relative h-full " > <div x-data='anchorMenu()' class="h-full" x-intersect.margin.-50%='setActiveLinkByID("73aeec65-8c73-44d3-a986-e1486d49d72c");'> <div class="contentGridItem__container relative h-full" dir="ltr"> <div class="background--73aeec65-8c73-44d3-a986-e1486d49d72c py-16 md:py-8 lg:py-8 px-0 md:px-0 lg:px-0 text-primary h-full animateImage bg-transparent relative z-10"> <div class="ContentGrid container max-w-full mx-auto "> <div class="flex md:flex lg:flex-row flex-wrap -mx-0 py-0 md:-mx-0 md:py-0 lg:-mx-0 lg:py-0"> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-8 px-0 md:px-0 lg:px-0 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> </div> </div> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-16 md:py-0 lg:py-8 px-0 md:px-0 lg:px-0 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> </div> </div> </div> </div> <div class=""></div> </div> </div> </div> </section> </div> </div> </div> </div> <div class=""></div> </div> </div> </div> </section> </div> </div> <div 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animateImage bg-transparent relative z-10"> <div class="ContentGrid container mx-auto "> <div class="flex md:flex md:flex-row lg:flex-row flex-wrap justify-center items-center -mx-0 py-0 md:-mx-0 md:py-0 lg:-mx-1 lg:py-1"> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-1 lg:px-1 w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 items-center self-auto bg-transparent" x-data="" dir="ltr"> <section id="9d7366e4-ab9a-46ff-aeb6-04f9a6fe0a26" class="contentGridItem--9d7366e4-ab9a-46ff-aeb6-04f9a6fe0a26 contentGridItem relative h-full " > <div x-data='anchorMenu()' class="h-full" x-intersect.margin.-50%='setActiveLinkByID("9d7366e4-ab9a-46ff-aeb6-04f9a6fe0a26");'> <div class="contentGridItem__container relative h-full" dir="ltr"> <div class="background--9d7366e4-ab9a-46ff-aeb6-04f9a6fe0a26 py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 text-primary h-full animateImage bg-transparent relative z-10"> <div 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lg:pb-4 md:pt-0 md:pb-0 pt-0 pb-0"> <div class="flex md:flex md:flex-row lg:flex-row flex-wrap justify-center items-center -mx-0 py-0 md:-mx-0 md:py-0 lg:-mx-0 lg:py-0"> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full lg:w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-4 md:py-4 lg:py-4 px-0 md:px-0 lg:px-0 items-center self-auto bg-primary2" x-data="" dir="ltr"> <section id="6b471239-ec97-4454-bf6e-d76bc74488c3" class="contentGridItem--6b471239-ec97-4454-bf6e-d76bc74488c3 contentGridItem relative h-full " > <div x-data='anchorMenu()' class="h-full" x-intersect.margin.-50%='setActiveLinkByID("6b471239-ec97-4454-bf6e-d76bc74488c3");'> <div class="contentGridItem__container relative h-full" dir="ltr"> <div class="background--6b471239-ec97-4454-bf6e-d76bc74488c3 py-4 md:py-4 lg:py-4 px-0 md:px-0 lg:px-0 text-primary h-full animateImage bg-primary2 relative z-10"> <div class="ContentGrid container mx-auto "> <div class="flex md:flex md:flex-row lg:flex-row flex-wrap justify-center items-center -mx-0 py-0 md:-mx-0 md:py-0 lg:-mx-0 lg:py-0"> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full lg:w-9/12 self-auto " > <div style="" class="ContentSectionItem h-full w-full py-4 md:py-4 lg:py-4 px-8 md:px-8 lg:px-8 self-auto contentBlock flex flex-col text-center md:text-center lg:text-center text- bg- bg-transparent" x-data="" dir="ltr"> <div class="flex items-center justify-start md:justify-center lg:justify-center "> <h1 class="contentBlock__title mb-4 text-title-2 font-title text-primary1">KEVZARA is the first biologic therapy approved for the treatment of PMR</h1> </div> <div class="rich-text mt-3 text-base font-body"> <p style="text-align: center;"><span class="text-title-4"><span class="text-primary1"><strong>KEVZARA is not a steroid.</strong></span></span></p> </div> </div> </div> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full lg:w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-4 md:py-4 lg:py-4 px-4 md:px-8 lg:px-16 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text-primary1 bg- bg-transparent" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p style="text-align: center;"><u><span class="text-title-4"><a href="/pmr/about-pmr" style="font-family: 'Gotham-Bold';">Learn more about PMR</a></span></u></p> </div> </div> </div> </div> </div> <div class=""></div> </div> </div> </div> </section> </div> </div> </div> </div> <div class=""></div> </div> </div> </div> </section> <section id="091d59a2-7502-4170-9316-c5240db4dacd" class="contentGridItem--091d59a2-7502-4170-9316-c5240db4dacd contentGridItem relative h-full " > <div x-data='anchorMenu()' class="h-full" x-intersect.margin.-50%='setActiveLinkByID("091d59a2-7502-4170-9316-c5240db4dacd");'> <div class="contentGridItem__container relative h-full" dir="ltr"> <div 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class="background--3f6e13cf-ae22-4544-8ec8-be2d3ca04a80 py-0 md:py-0 lg:py-0 px-0 md:px-4 lg:px-0 text-primary h-full animateImage bg-transparent relative z-10"> <div class="ContentGrid container mx-auto "> <div class="flex md:flex md:flex-row lg:flex-row flex-wrap justify-center items-center -mx-0 py-0 md:-mx-0 md:py-0 lg:-mx-0 lg:py-0"> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-4/12 md:w-4/12 lg:w-4/12 self-auto " > <div style="" class="ContentSectionItem h-full w-full py-4 md:py-4 lg:py-0 px-4 md:px-4 lg:px-4 self-auto imageAttachment default default" x-data="" dir="ltr"> <div class="uiImage relative block w-full block" > <picture> <source srcset="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" data-srcset="/dam/jcr:789ce77e-142d-4a9e-bd96-f1eddfd90251/icon-pre-filled-pen.svg 767w, /dam/jcr:789ce77e-142d-4a9e-bd96-f1eddfd90251/icon-pre-filled-pen.svg 1200w" media="(max-width: 767px)" class=" " data-sizes="auto" /> <source srcset="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" data-srcset="/dam/jcr:789ce77e-142d-4a9e-bd96-f1eddfd90251/icon-pre-filled-pen.svg 767w, /dam/jcr:789ce77e-142d-4a9e-bd96-f1eddfd90251/icon-pre-filled-pen.svg 1200w" media="(min-width: 768px)" class="" data-sizes="auto" /> <img src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" data-src="/dam/jcr:789ce77e-142d-4a9e-bd96-f1eddfd90251/icon-pre-filled-pen.svg 767w, /dam/jcr:789ce77e-142d-4a9e-bd96-f1eddfd90251/icon-pre-filled-pen.svg 1200w" class="w-full lazyload " data-sizes="auto" alt="pre-filled pen icon" /> </picture> <div class="cardImageOverlay absolute top-0 left-0 w-full h-full block opacity-30 bg-bg-black" ></div> </div> </div> </div> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 items-center self-auto bg-transparent" x-data="" dir="ltr"> <section id="c895fdce-6ee9-4986-8e73-5157db7ce708" class="contentGridItem--c895fdce-6ee9-4986-8e73-5157db7ce708 contentGridItem relative h-full " > <div x-data='anchorMenu()' class="h-full" x-intersect.margin.-50%='setActiveLinkByID("c895fdce-6ee9-4986-8e73-5157db7ce708");'> <div class="contentGridItem__container relative h-full" dir="ltr"> <div class="background--c895fdce-6ee9-4986-8e73-5157db7ce708 py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 text-primary h-full animateImage bg-transparent relative z-10"> <div class="ContentGrid container mx-auto "> <div class="flex md:flex md:flex-row lg:flex-row flex-wrap justify-center items-center -mx-0 py-0 md:-mx-0 md:py-0 lg:-mx-0 lg:py-0"> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full lg:w-9/12 self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-4 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p style="text-align: center;"><span class="text-primary1"><strong>How KEVZARA may help</strong></span></p> <p style="text-align: center;"><span class="text-primary1">KEVZARA may help relieve signs and symptoms of PMR when used with a tapering dose of steroids.</span></p> </div> </div> </div> </div> </div> <div class=""></div> </div> </div> </div> </section> </div> </div> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full lg:w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-4 md:py-4 lg:py-4 px-8 md:px-8 lg:px-4 self-auto bg-transparent" x-data="" dir="ltr"> <div class='w-full flex justify-center'> <a class="button button--tertiary text-center font-title overflow-hidden inline-block border text-size-default border rounded-full border-solid w-full text-center " @click=" $dispatch('track-event', { 'event': 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class="contentGridItem--9c00e0c2-31ac-411b-890c-f981e4733fe9 contentGridItem relative h-full " > <div x-data='anchorMenu()' class="h-full" x-intersect.margin.-50%='setActiveLinkByID("9c00e0c2-31ac-411b-890c-f981e4733fe9");'> <div class="contentGridItem__container relative h-full" dir="ltr"> <div class="background--9c00e0c2-31ac-411b-890c-f981e4733fe9 py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 text-primary h-full animateImage bg-transparent relative z-10"> <div class="ContentGrid container mx-auto "> <div class="flex md:flex md:flex-row lg:flex-row flex-wrap justify-center items-center -mx-0 py-0 md:-mx-0 md:py-0 lg:-mx-0 lg:py-0"> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full lg:w-9/12 self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p style="text-align: center;"><span class="text-primary1"><strong>Stay connected with KEVZARA</strong></span></p> <p style="text-align: center;"><span class="text-primary1">Join the KEVZARA mailing list to receive useful resources to help you get started on treatment.</span></p> </div> </div> </div> </div> </div> <div class=""></div> </div> </div> </div> </section> </div> </div> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full md:w-full lg:w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-4 md:py-4 lg:py-4 px-8 md:px-8 lg:px-8 self-auto bg-transparent" x-data="" dir="ltr"> <div class='w-full flex justify-center'> <a class="button button--tertiary text-center font-title overflow-hidden inline-block border text-size-default border rounded-full border-solid w-full text-center " @click=" $dispatch('track-event', { 'event': 'cmp_event', 'event_type': 'cta', 'title': `Sign up now`, 'context': 'other' 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" > <div x-data='anchorMenu()' class="h-full" x-intersect.margin.-50%='setActiveLinkByID("50e5408c-8271-4484-bcae-6606dff06e5d");'> <div class="contentGridItem__container relative h-full" dir="ltr"> <div class="background--50e5408c-8271-4484-bcae-6606dff06e5d py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 text-primary h-full animateImage bg-transparent relative z-10"> <div class="ContentGrid container mx-auto "> <div class="flex md:flex md:flex-row lg:flex-row flex-wrap justify-center items-center -mx-0 py-0 md:-mx-0 md:py-0 lg:-mx-0 lg:py-0"> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full lg:w-9/12 self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-4 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p style="text-align: center;"><span class="text-primary1"><strong>Save on your copay</strong></span></p> <p style="text-align: center;"><span class="text-primary1">Pay as little as $0 in copay costs.*<br /> <a href="." style="font-size:14px;pointer-events:none;">*Eligibility restrictions apply.</a></span></p> </div> </div> </div> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full lg:w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> </div> </div> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-1/12 md:w-1/12 lg:w-auto self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 self-auto imageAttachment default default" x-data="" dir="ltr"> <div class="uiImage relative block w-full block" > <picture> <source 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scrollMod: null, uuid: config.uuid, contextPath: config.contextPath, isIsiCollapsed: false, isIsiExpanded: false, isIntersecting: false, isDesktop: this.getDesktopValue, get getDesktopValue() { this.isDesktop = this.$breakpointIs("lg"); }, leaveIsi() { const rect = this.$el.getBoundingClientRect(); // Check if the top of the element is at or above the top of the viewport if (rect.top >= 0) { this.isIntersecting = false; } }, async init() { this.isValidSession(); this.getDesktopValue; this.scrollMod = await import(this.contextPath + "/.resources/sanofi-lm-platform/themes/sanofi-platform/src/js/modules/scrollTo.js"); this.attachEventListenersToAnchors(); //watch to Isi collapsed value and change height & max height accordingly this.$watch("isIsiCollapsed", (value) => { if (value) { this.restoreScroll(); let maxHeight = this.isDesktop ? 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KEVZARA can lower the ability of your immune system to fight infections. Some people have had serious infections while using KEVZARA, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have died from these infections. Your healthcare provider should test you for TB before starting KEVZARA. Your healthcare provider should monitor you closely for signs and symptoms of TB during treatment with KEVZARA.</strong></li> <li>Before starting KEVZARA, tell your healthcare provider if you <ul> <li>think you have an infection or have signs or symptoms of an infection, with or without a fever such as sweats or chills, muscle aches, a cough, shortness of breath, blood in your phlegm, weight loss, warm, red, or painful skin or sores on your body, diarrhea or stomach pain, burning when you urinate or urinating more often than normal, if you feel very tired, or if you are being treated for an infection, get a lot of infections or have repeated infections.</li> <li>have diabetes, HIV, or a weakened immune system.</li> <li>have TB, or have been in close contact with someone with TB.</li> <li>live or have lived, or have traveled to certain parts of the country (such as the Ohio and Mississippi River valleys and the Southwest) where there is an increased chance of getting certain fungal infections (histoplasmosis, coccidioidomycosis, or blastomycosis).</li> <li>have or have had hepatitis.</li> </ul> </li> <li>After starting KEVZARA, call your healthcare provider right away if you have any symptoms of an infection.</li> <li><strong>CHANGES IN CERTAIN LABORATORY TEST RESULTS:</strong> Your healthcare provider should do blood tests before and after starting KEVZARA to check for low neutrophil (white blood cells that help the body fight off bacterial infections) counts, low platelet (blood cells that help with blood clotting and stop bleeding) counts, and an increase in certain liver function tests. Changes in test results are common with KEVZARA and can be severe. You may also have changes in other laboratory tests, such as your blood cholesterol levels. Your healthcare provider should do blood tests 4 to 8 weeks after starting KEVZARA and then every 6 months during treatment to check for an increase in blood cholesterol levels.</li> <li><strong>TEARS (PERFORATION) OF THE STOMACH OR INTESTINES: </strong>Tell your healthcare provider if you have had a condition known as diverticulitis (inflammation in parts of the large intestine) or ulcers in your stomach or intestines. Some people using KEVZARA get tears in their stomach or intestine. This happens most often in people who also take nonsteroidal anti-inflammatory drugs (NSAIDS), corticosteroids, or methotrexate. Call your healthcare provider right away if you have fever and stomach (abdominal) pain that does not go away.</li> <li><strong>CANCER:</strong> KEVZARA may increase your risk of certain cancers by changing the way your immune system works. Tell your healthcare provider if you have ever had any type of cancer.</li> <li><strong>SERIOUS ALLERGIC REACTIONS: </strong>Serious allergic reactions can happen with KEVZARA. Get medical attention right away if you have any of the following signs: shortness of breath or trouble breathing; feeling dizzy or faint; swelling of your lips, tongue, or face; moderate or severe stomach (abdominal) pain or vomiting; or chest pain.</li> <li>Do not use KEVZARA if you are allergic to sarilumab or any of the ingredients of KEVZARA.</li> <li>Before using KEVZARA, tell your healthcare provider if you <ul> <li>have an infection.</li> <li>have liver problems.</li> <li>have had stomach (abdominal) pain or a condition known as diverticulitis (inflammation in parts of the large intestine) or ulcers in your stomach or intestines.</li> <li>recently received or are scheduled to receive a vaccine. People who take KEVZARA should not receive live vaccines. <ul> <li>All vaccines should be brought up-to-date before starting KEVZARA, unless urgent treatment initiation is required.</li> </ul> </li> <li>plan to have surgery or a medical procedure.</li> <li>are pregnant or plan to become pregnant. It is not known if KEVZARA will harm your unborn baby.</li> <li>are breastfeeding or plan to breastfeed. Talk to your healthcare provider about the best way to feed your baby if you use KEVZARA. It is not known if KEVZARA passes into your breast milk.</li> <li>take prescription or nonprescription medicines, vitamins, or herbal supplements. It is especially important to tell your healthcare provider if you use: <ul> <li>any other medicines to treat your PMR. Using KEVZARA with these medicines may increase your risk of infection.</li> <li>medicines that affect the way certain liver enzymes work. Ask your healthcare provider if you are not sure if your medicine is one of these.</li> </ul> </li> </ul> </li> <li>The most common side effects include: <ul> <li>injection site redness</li> <li>injection site itching</li> <li>upper respiratory tract infection</li> <li>urinary tract infection</li> <li>nasal congestion, sore throat, and runny nose</li> </ul> </li> </ul> <p><strong>These are not all the possible side effects of KEVZARA. Tell your doctor about any side effect that bothers you or does not go away. You are encouraged to report side effects of prescription drugs to the FDA at <a href="https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program" target="_blank"><u>www.fda.gov/medwatch</u></a> or call <a href="tel:1-800-FDA-1088">1-800-FDA-1088</a>.</strong><br /> <br /> <em>To learn more, talk about KEVZARA with your healthcare provider or pharmacist. The FDA-approved Medication Guide and Prescribing Information can be found at <u><a href="https://www.kevzara.com/" target="_blank">www.KEVZARA.com</a></u> or by calling <a href="tel:1-844-538-9272">1-844-KEVZARA.</a></em><br /> <br /> <span class="text-primary1"><strong>Please click here to see full <a href="https://products.sanofi.us/Kevzara/Kevzara.pdf" target="_blank"><u>Prescribing Information</u></a>, including risk of SERIOUS SIDE EFFECTS, and <a href="https://products.sanofi.us/kevzara/kevzara_medguide.pdf" target="_blank"><u>Medication Guide</u>.</a></strong></span></p> </div> </div> </div> <div class="gridComponent mb-4 mt-3 flex flex-col w-full md:w-full lg:w-6/12 self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-4 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p><strong><span class="text-primary1">What is KEVZARA?</span></strong><br /> <br /> KEVZARA is an injectable prescription medicine called an interleukin-6 (IL-6) receptor blocker. KEVZARA is used to treat adult patients with polymyalgia rheumatica (PMR) after corticosteroids have been used and did not work well or when a slow decrease in the dose of corticosteroids (taper) cannot be tolerated.</p> </div> </div> </div> <div class="gridComponent mb-4 mt-3 flex flex-col w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-4 md:py-4 lg:py-4 px-4 md:px-4 lg:px-4 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg-secondary2 secondary2" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p><em>The health information contained herein is provided for general educational purposes only. Your healthcare provider is the single best source of information regarding your health. Please consult your healthcare provider if you have any questions about your health or treatment.</em></p> </div> </div> </div> </div> </div> </div> </div> </div> <div style="height: 23.5%" :class="!isIntersecting || 'invisible opacity-0'" class="isi-tray z-50 transition-opacity fixed bottom-0 left-0 right-0 bg-white mb-0 border-t border-"> <div class="isiTray__contentSectionItem flex flex-col lg:flex-row py-4 md:py-4 lg:py-4 px-4 md:px-8 lg:px-8 w-full container mx-auto"> <div class="flex"> <h3 class="mobile-title pt-1 text- text-title-6 font-title w-auto lg:w-full block lg:hidden"> </h3> <a href="#in-page-isi" aria-label="Read more" class="h-5 md:h-auto ml-auto font-title text-primary1 text-base md:text-lg flex items-start md:items-center justify-end relative md:absolute right-2 top-2 md:top-1 mr-0 md:mr-4 whitespace-nowrap md:whitespace-normal"> <span class="hidden sm:block">Read more</span> <svg class="w-5 h-6 ml-1.5 fill-current" aria-hidden="true" role="img"> <use xlink:href="/.resources/sanofi-lm-platform/themes/sanofi-platform/src/img/sprites/global.svg#chevron-circle-down"></use> </svg> </a> </div> <div class="ContentGrid "> <div class="flex md:flex lg:flex-row flex-wrap "> <div class="gridComponent mb-4 mt-3 flex flex-col w-full md:w-full lg:w-6/12 self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-0 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p><strong><span class="text-primary1">IMPORTANT SAFETY INFORMATION</span><br /> <br /> KEVZARA® (sarilumab</strong>)<strong> can cause serious side effects including:</strong></p> <ul> <li><strong>SERIOUS INFECTIONS: KEVZARA is a medicine that affects your immune system. KEVZARA can lower the ability of your immune system to fight infections. Some people have had serious infections while using KEVZARA, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have died from these infections. Your healthcare provider should test you for TB before starting KEVZARA. Your healthcare provider should monitor you closely for signs and symptoms of TB during treatment with KEVZARA.</strong></li> <li>Before starting KEVZARA, tell your healthcare provider if you <ul> <li>think you have an infection or have signs or symptoms of an infection, with or without a fever such as sweats or chills, muscle aches, a cough, shortness of breath, blood in your phlegm, weight loss, warm, red, or painful skin or sores on your body, diarrhea or stomach pain, burning when you urinate or urinating more often than normal, if you feel very tired, or if you are being treated for an infection, get a lot of infections or have repeated infections.</li> <li>have diabetes, HIV, or a weakened immune system.</li> <li>have TB, or have been in close contact with someone with TB.</li> <li>live or have lived, or have traveled to certain parts of the country (such as the Ohio and Mississippi River valleys and the Southwest) where there is an increased chance of getting certain fungal infections (histoplasmosis, coccidioidomycosis, or blastomycosis).</li> <li>have or have had hepatitis.</li> </ul> </li> <li>After starting KEVZARA, call your healthcare provider right away if you have any symptoms of an infection.</li> <li><strong>CHANGES IN CERTAIN LABORATORY TEST RESULTS:</strong> Your healthcare provider should do blood tests before and after starting KEVZARA to check for low neutrophil (white blood cells that help the body fight off bacterial infections) counts, low platelet (blood cells that help with blood clotting and stop bleeding) counts, and an increase in certain liver function tests. Changes in test results are common with KEVZARA and can be severe. You may also have changes in other laboratory tests, such as your blood cholesterol levels. Your healthcare provider should do blood tests 4 to 8 weeks after starting KEVZARA and then every 6 months during treatment to check for an increase in blood cholesterol levels.</li> <li><strong>TEARS (PERFORATION) OF THE STOMACH OR INTESTINES: </strong>Tell your healthcare provider if you have had a condition known as diverticulitis (inflammation in parts of the large intestine) or ulcers in your stomach or intestines. Some people using KEVZARA get tears in their stomach or intestine. This happens most often in people who also take nonsteroidal anti-inflammatory drugs (NSAIDS), corticosteroids, or methotrexate. Call your healthcare provider right away if you have fever and stomach (abdominal) pain that does not go away.</li> <li><strong>CANCER:</strong> KEVZARA may increase your risk of certain cancers by changing the way your immune system works. Tell your healthcare provider if you have ever had any type of cancer.</li> <li><strong>SERIOUS ALLERGIC REACTIONS: </strong>Serious allergic reactions can happen with KEVZARA. Get medical attention right away if you have any of the following signs: shortness of breath or trouble breathing; feeling dizzy or faint; swelling of your lips, tongue, or face; moderate or severe stomach (abdominal) pain or vomiting; or chest pain.</li> <li>Do not use KEVZARA if you are allergic to sarilumab or any of the ingredients of KEVZARA.</li> <li>Before using KEVZARA, tell your healthcare provider if you <ul> <li>have an infection.</li> <li>have liver problems.</li> <li>have had stomach (abdominal) pain or a condition known as diverticulitis (inflammation in parts of the large intestine) or ulcers in your stomach or intestines.</li> <li>recently received or are scheduled to receive a vaccine. People who take KEVZARA should not receive live vaccines. <ul> <li>All vaccines should be brought up-to-date before starting KEVZARA, unless urgent treatment initiation is required.</li> </ul> </li> <li>plan to have surgery or a medical procedure.</li> <li>are pregnant or plan to become pregnant. It is not known if KEVZARA will harm your unborn baby.</li> <li>are breastfeeding or plan to breastfeed. Talk to your healthcare provider about the best way to feed your baby if you use KEVZARA. It is not known if KEVZARA passes into your breast milk.</li> <li>take prescription or nonprescription medicines, vitamins, or herbal supplements. It is especially important to tell your healthcare provider if you use: <ul> <li>any other medicines to treat your PMR. Using KEVZARA with these medicines may increase your risk of infection.</li> <li>medicines that affect the way certain liver enzymes work. Ask your healthcare provider if you are not sure if your medicine is one of these.</li> </ul> </li> </ul> </li> <li>The most common side effects include: <ul> <li>injection site redness</li> <li>injection site itching</li> <li>upper respiratory tract infection</li> <li>urinary tract infection</li> <li>nasal congestion, sore throat, and runny nose</li> </ul> </li> </ul> <p><strong>These are not all the possible side effects of KEVZARA. Tell your doctor about any side effect that bothers you or does not go away. You are encouraged to report side effects of prescription drugs to the FDA at <a href="https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program" target="_blank"><u>www.fda.gov/medwatch</u></a> or call <a href="tel:1-800-FDA-1088">1-800-FDA-1088</a>.</strong><br /> <br /> <em>To learn more, talk about KEVZARA with your healthcare provider or pharmacist. The FDA-approved Medication Guide and Prescribing Information can be found at <u><a href="https://www.kevzara.com/" target="_blank">www.KEVZARA.com</a></u> or by calling <a href="tel:1-844-538-9272">1-844-KEVZARA.</a></em><br /> <br /> <span class="text-primary1"><strong>Please click here to see full <a href="https://products.sanofi.us/Kevzara/Kevzara.pdf" target="_blank"><u>Prescribing Information</u></a>, including risk of SERIOUS SIDE EFFECTS, and <a href="https://products.sanofi.us/kevzara/kevzara_medguide.pdf" target="_blank"><u>Medication Guide</u>.</a></strong></span></p> </div> </div> </div> <div class="gridComponent mb-4 mt-3 flex flex-col w-full md:w-full lg:w-6/12 self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-0 md:px-0 lg:px-4 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p><strong><span class="text-primary1">What is KEVZARA?</span></strong><br /> <br /> KEVZARA is an injectable prescription medicine called an interleukin-6 (IL-6) receptor blocker. KEVZARA is used to treat adult patients with polymyalgia rheumatica (PMR) after corticosteroids have been used and did not work well or when a slow decrease in the dose of corticosteroids (taper) cannot be tolerated.</p> </div> </div> </div> <div class="gridComponent mb-4 mt-3 flex flex-col w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-4 md:py-4 lg:py-4 px-4 md:px-4 lg:px-4 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg-secondary2 secondary2" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p><em>The health information contained herein is provided for general educational purposes only. Your healthcare provider is the single best source of information regarding your health. 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class="background--5ef6becc-56f4-496b-953c-ae6f66cdc91b py-0 md:py-0 lg:py-4 px-0 md:px-4 lg:px-4 text-primary h-full animateImage bg-transparent relative z-10"> <div class="ContentGrid container mx-auto "> <div class="flex md:flex md:flex-row lg:flex-row flex-wrap justify-center items-center -mx-0 py-0 md:-mx-0 md:py-0 lg:-mx-0 lg:py-0"> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-4 md:px-0 lg:px-0 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p><span class="text-white">©2024 Sanofi and Regeneron Pharmaceuticals, Inc. 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<strong><u><a href="https://contactus.sanofi-aventis.us" target="_blank">Contact Sanofi US</a></u></strong>, or call <a href="tel:1-877-734-6777">1-877-734-6777</a> to contact Regeneron Pharmaceuticals, Inc.</span></p> </div> </div> </div> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-4 md:px-0 lg:px-0 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p><span class="text-white">This site is intended for use by U.S. Residents only.</span></p> </div> </div> </div> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-4 md:px-0 lg:px-0 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p><a href="." style="line-height:2; pointer-events: none;"><span class="text-white">MAT-US-2304908-v1.0-11/2023<br>Last Updated: June 2024</span></a></p> </div> </div> </div> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-4 md:px-0 lg:px-0 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p><span class="text-white">Sanofi US is hosting this website on behalf of Sanofi and Regeneron Pharmaceuticals, Inc.</span></p> </div> </div> </div> <div class="gridComponent flex flex-col my-0 px-0 md:my-0 md:px-0 lg:my-0 lg:px-0 w-full self-auto " > <div style="" class="ContentSectionItem h-full w-full py-0 md:py-0 lg:py-0 px-4 md:px-0 lg:px-0 self-auto contentBlock flex flex-col text-left md:text-left lg:text-left text- bg- bg-transparent" x-data="" dir="ltr"> <div class="rich-text mt-3 text-base font-body"> <p><span class="text-white">Sanofi and Regeneron are industry partners, who are committed to handling personal data in ways that respect your privacy. 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