TGF beta 1/2/3 Antibody (1D11) [Unconjugated] (MAB1835): Novus Biologicals

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View Mouse Monoclonal anti-TGF beta 1/2/3 Antibody (1D11) [Unconjugated] (MAB1835). Validated Applications: WB, B/N, ELISA(Cap). Validated Species: Multi-Species. Sample size available." /> <meta property="og:description" content="Cited in 226 publications. View Mouse Monoclonal anti-TGF beta 1/2/3 Antibody (1D11) [Unconjugated] (MAB1835). Validated Applications: WB, B/N, ELISA(Cap). Validated Species: Multi-Species. Sample size available." /> <meta property="og:image" content="//images.novusbio.com/thumbnails2/TGF-beta_1,_2,_3_MAB1835_Block_Neutralize_9045.jpg" /> <meta name="robots" content="index,follow" /> <meta name="baidu-site-verification" content="xQr2vSIwwB" /> <script id="json-ld" type="application/ld+json">[{"@context":"http://schema.org","@type":"Product","description":"Cited in 226 publications. View Mouse Monoclonal anti-TGF beta 1/2/3 Antibody (1D11) [Unconjugated] (MAB1835). Validated Applications: WB, B/N, ELISA(Cap). Validated Species: Multi-Species. 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</div> <div class="main grid_16">  <h1>TGF beta 1/2/3 Antibody (1D11) [Unconjugated]</h1> </div> <div class="clear"></div> <div> <div class="region region-content"> <div id="block-et-messages-et-messages-block" class="block block-et-messages"> <div class="content"> <span></span> </div> </div> <div id="block-system-main" class="block block-system"> <div class="content"> <div class="grid_16"><div class="ds_info float_left"><a href="#PublicationSection"><div class="sprite_pubBook_large"></div></a> <a href="#PublicationSection" class="bottom2"><span class="ctr">(226 Publications)</span></a></div><div class="ds_info float_left"> <a href="/common-name/tgf-beta-1-2-3"><div class="sprite_allRelated"></div></a> <a href="/common-name/tgf-beta-1-2-3" class="bottom4"><span class="ctr">See All Related</span></a> </div><div class="ds_info float_left"><a href="/reviews/MAB1835"><div class="dsSprite_submitreview"></div></a> <a href="/reviews/MAB1835" class="bottom4"><span class="ctr">Submit a Review</span></a></div></div></div><div class="modalWrapper" style="display:none;"> <h2>Species Glossary</h2> <hr class="customhr"/> <img src="//images.novusbio.com/design/bunny.gif" alt="Species Glossary Rabbit" style="float: right;"> <table class="modalTable"> <tr> <td>At</td> <td>=</td> <td>A. thaliana</td> <td>SyHa</td> <td>=</td> <td>Golden Syrian Hamster</td> </tr> <tr> <td>All</td> <td>=</td> <td>All Species</td> <td>Ha</td> <td>=</td> <td>Hamster</td> </tr> <tr> <td>An</td> <td>=</td> <td>Animal</td> <td>Hu</td> <td>=</td> <td>Human</td> </tr> <tr> <td>ArHa</td> <td>=</td> <td>Armenian Hamster</td> <td>I</td> <td>=</td> <td>Insect</td> </tr> <tr> <td>Av</td> <td>=</td> <td>Avian</td> <td>Ll</td> <td>=</td> <td>Llama</td> </tr> <tr> <td>Bb</td> <td>=</td> <td>Baboon</td> <td>Ma</td> <td>=</td> <td>Mammal</td> </tr> <tr> <td>Ba</td> <td>=</td> <td>Bacteria</td> <td>Mk</td> <td>=</td> <td>Monkey</td> </tr> <tr> <td>Bv</td> <td>=</td> <td>Bovine</td> <td>Mu</td> <td>=</td> <td>Mouse</td> </tr> <tr> <td>Ca</td> <td>=</td> <td>Canine</td> <td>Multi</td> <td>=</td> <td>Multi-species</td> </tr> <tr> <td>Ce</td> <td>=</td> <td>C. Elegans</td> <td>NA</td> <td>=</td> <td>Non-species specific</td> </tr> <tr> <td>Ch</td> <td>=</td> <td>Chicken</td> <td>Or</td> <td>=</td> <td>Orangutan</td> </tr> <tr> <td>ChHa</td> <td>=</td> <td>Chinese Hamster</td> <td>Pl</td> <td>=</td> <td>Plant</td> </tr> <tr> <td>Cm</td> <td>=</td> <td>Cynomolgus Monkey</td> <td>Pm</td> <td>=</td> <td>Primate</td> </tr> <tr> <td>Do</td> <td>=</td> <td>Donkey</td> <td>Po</td> <td>=</td> <td>Porcine</td> </tr> <tr> <td>Dr</td> <td>=</td> <td>Drosophilia</td> <td>Rb</td> <td>=</td> <td>Rabbit</td> </tr> <tr> <td>Ec</td> <td>=</td> <td>E. Coli</td> <td>Rt</td> <td>=</td> <td>Rat</td> </tr> <tr> <td>Eq</td> <td>=</td> <td>Equine</td> <td>RM</td> <td>=</td> <td>Rhesus Macaque</td> </tr> <tr> <td>Fe</td> <td>=</td> <td>Feline</td> <td>Sh</td> <td>=</td> <td>Sheep</td> </tr> <tr> <td>Ft</td> <td>=</td> <td>Ferret</td> <td>Vb</td> <td>=</td> <td>Vertebrate</td> </tr> <tr> <td>Fi</td> <td>=</td> <td>Fish</td> <td>Vi</td> <td>=</td> <td>Virus</td> </tr> <tr> <td>Fu</td> <td>=</td> <td>Fungi</td> <td>Xp</td> <td>=</td> <td>Xenopus</td> </tr> <tr> <td>Ge</td> <td>=</td> <td>Gerbil</td> <td>Ye</td> <td>=</td> <td>Yeast</td> </tr> <tr> <td>GP</td> <td>=</td> <td>Guinea Pig</td> <td>Ze</td> <td>=</td> <td>Zebrafish</td> </tr> <tr> <td>Gt</td> <td>=</td> <td>Goat</td> </tr> </table> <div style="text-align: center;margin-left:25px;margin-right:25px;"> <p>Note: Mouseover a species abbreviation on the product page to display the fullname.</p> </div> </div> </div><div class="clear"></div><div class="grid_10 pos_relative"><div class="ds_blue_border equaltop"><div class="imagesleft equaltop"><h2 class="blueHead">Images</h2> <div class="midBlue"> </div><div class="images"><div id="ss_prev_top" class="cycle-pager"><div class="pager_left_on"></div></div><div class="cycle-slideshow slideshows" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-top" data-cycle-prev="#ss_prev_top" data-cycle-next="#ss_next_top" data-cycle-caption="#image-caption" data-cycle-caption-template="Image {{slideNum}} of {{slideCount}}" data-cycle-slides=".big_thumb_container" data-cycle-carousel-visible="5" id="images_cycle" > <div class="sub_image_wrapper"><div id="cycle-circle-pager-top" class="cycle-circle-pager"></div><div id="image-caption"></div> <a class="enlargeTop">(<div class="dsSprite_magGlass"></div> Enlarge)</a></div> <div class="big_thumb_container"> <div class="image_wrapper"> <a href="//images.novusbio.com/fullsize2/TGF-beta_1,_2,_3_MAB1835_Block_Neutralize_9045.jpg" class="top_images" rel="gallery" title="Recombinant Human TGF‑ beta 1 (Catalog # 240‑B) inhibits Recombinant Mouse IL‑4 (Catalog # 404-ML) induced proliferation in the HT‑2 mouse T cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Mouse IL‑4 (7.5 ng/mL) activity elicited by Recombinant Human TGF‑ beta 1 (1 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-TGF‑ beta 1, 2, 3 Monoclonal Antibody (Catalog # MAB1835). The ND50 is typically0.25‑1.25 µg/mL." > <img src="//images.novusbio.com/images2/TGF-beta_1,_2,_3_MAB1835_Block_Neutralize_9045.jpg" class="big_thumb" alt="Recombinant Human TGF‑ beta 1 (Catalog # 240‑B) inhibits Recombinant Mouse IL‑4 (Catalog # 404-ML) induced proliferation in the HT‑2 mouse T cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Mouse IL‑4 (7.5 ng/mL) activity elicited by Recombinant Human TGF‑ beta 1 (1 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-TGF‑ beta 1, 2, 3 Monoclonal Antibody (Catalog # MAB1835). The ND50 is typically0.25‑1.25 µg/mL." title="Recombinant Human TGF‑ beta 1 (Catalog # 240‑B) inhibits Recombinant Mouse IL‑4 (Catalog # 404-ML) induced proliferation in the HT‑2 mouse T cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Mouse IL‑4 (7.5 ng/mL) activity elicited by Recombinant Human TGF‑ beta 1 (1 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-TGF‑ beta 1, 2, 3 Monoclonal Antibody (Catalog # MAB1835). The ND50 is typically0.25‑1.25 µg/mL." /> </a> </div> <div class="alt-caption padding_left5" >Recombinant Human TGF‑ beta 1 (Catalog # 240‑B) inhibits Recombinant Mouse IL‑4 (Catalog # 404-ML) induced proliferation in the HT‑2 mouse T cell line in a dose-dependent manner (orange line). Inhibition of<a class="openGallery" href="#" data-picnum="0"> ...read more</a></div> </div> <div class="big_thumb_container"> <div class="image_wrapper"> <a href="//images.novusbio.com/fullsize/mab1835_tgf-beta-1-2-3-mab-clone-1d11-41202410321414.jpg" class="top_images" rel="gallery" title="Apoptotic cell-induced immunomodulation in mice with collagen-induced arthritis (CIA) is dependent on transforming growth factor (TGF)-beta . CIA mice that received or did not receive apoptotic cells, with or without anti-TGF-beta blocking antibody were scored daily (a). Data are shown as mean ± SEM of five mice per group from one of two representative experiments; *p < 0.05, **p < 0.01 (Friedman test analysis of variance (ANOVA) with Dunn's multiple comparisons test). Anti-collagen IgG2a antibodies (Ab) were quantified in plasma (b). Data from 5 to 16 mice from two to three independent experiments (no difference, Kruskal-Wallis test ANOVA with Dunn’s multiple comparisons test). Lymph node cells were collected, cultured, and T cell proliferation in response to collagen protein or CD3-specific Ab stimulations was evaluated (c). Data are shown as mean ± SEM from one of two representative experiments; *p < 0.05, **p < 0.01 (nonparametric unpaired t test). Percent and absolute number of Foxp3+ T regulatory cells (Treg) were evaluated in the spleen (d) and suppressive assays were performed by isolating and adding Treg at a different ratio into collagen-specific cultures and responder T cell proliferation was assessed (e). Data are shown as mean ± SEM from one experiment (d Kruskal-Wallis test ANOVA with Dunn’s multiple comparisons test; e Friedman test ANOVA with Dunn’s multiple comparisons test). Plasmacytoid dendritic cells (pDC), conventional dendritic cells (cDC) and macrophages (macro) were isolated and cultured with naïve allogenic T cells to determine Treg polarization (f), and their response to TLR ligand was assessed through evaluation of CD40 costimulatory molecule expression (g). Data from individual mouse plus mean (black bar) from one experiment representative of four are shown; *p < 0.05, ***p < 0.001 (f ordinary one-way ANOVA with Tukey’s multiple comparisons test; g Kruskal-Wallis test ANOVA with Dunn’s multiple comparisons test). BrDU 5-Bromo-2’-deoxyuridine Image collected and cropped by CiteAb from the following publication (//arthritis-research.biomedcentral.com/articles/10.1186/s13075-016-1084-0), licensed under a CC-BY license. Not internally tested by R&D Systems." > <img src="//images.novusbio.com/images/mab1835_tgf-beta-1-2-3-mab-clone-1d11-41202410321414.jpg" loading="lazy" style="display:none;" class="big_thumb" alt="Apoptotic cell-induced immunomodulation in mice with collagen-induced arthritis (CIA) is dependent on transforming growth factor (TGF)-beta . CIA mice that received or did not receive apoptotic cells, with or without anti-TGF-beta blocking antibody were scored daily (a). Data are shown as mean ± SEM of five mice per group from one of two representative experiments; *p < 0.05, **p < 0.01 (Friedman test analysis of variance (ANOVA) with Dunn's multiple comparisons test). Anti-collagen IgG2a antibodies (Ab) were quantified in plasma (b). Data from 5 to 16 mice from two to three independent experiments (no difference, Kruskal-Wallis test ANOVA with Dunn’s multiple comparisons test). Lymph node cells were collected, cultured, and T cell proliferation in response to collagen protein or CD3-specific Ab stimulations was evaluated (c). Data are shown as mean ± SEM from one of two representative experiments; *p < 0.05, **p < 0.01 (nonparametric unpaired t test). Percent and absolute number of Foxp3+ T regulatory cells (Treg) were evaluated in the spleen (d) and suppressive assays were performed by isolating and adding Treg at a different ratio into collagen-specific cultures and responder T cell proliferation was assessed (e). Data are shown as mean ± SEM from one experiment (d Kruskal-Wallis test ANOVA with Dunn’s multiple comparisons test; e Friedman test ANOVA with Dunn’s multiple comparisons test). Plasmacytoid dendritic cells (pDC), conventional dendritic cells (cDC) and macrophages (macro) were isolated and cultured with naïve allogenic T cells to determine Treg polarization (f), and their response to TLR ligand was assessed through evaluation of CD40 costimulatory molecule expression (g). Data from individual mouse plus mean (black bar) from one experiment representative of four are shown; *p < 0.05, ***p < 0.001 (f ordinary one-way ANOVA with Tukey’s multiple comparisons test; g Kruskal-Wallis test ANOVA with Dunn’s multiple comparisons test). BrDU 5-Bromo-2’-deoxyuridine Image collected and cropped by CiteAb from the following publication (//arthritis-research.biomedcentral.com/articles/10.1186/s13075-016-1084-0), licensed under a CC-BY license. Not internally tested by R&D Systems." title="Apoptotic cell-induced immunomodulation in mice with collagen-induced arthritis (CIA) is dependent on transforming growth factor (TGF)-beta . CIA mice that received or did not receive apoptotic cells, with or without anti-TGF-beta blocking antibody were scored daily (a). Data are shown as mean ± SEM of five mice per group from one of two representative experiments; *p < 0.05, **p < 0.01 (Friedman test analysis of variance (ANOVA) with Dunn's multiple comparisons test). Anti-collagen IgG2a antibodies (Ab) were quantified in plasma (b). Data from 5 to 16 mice from two to three independent experiments (no difference, Kruskal-Wallis test ANOVA with Dunn’s multiple comparisons test). Lymph node cells were collected, cultured, and T cell proliferation in response to collagen protein or CD3-specific Ab stimulations was evaluated (c). Data are shown as mean ± SEM from one of two representative experiments; *p < 0.05, **p < 0.01 (nonparametric unpaired t test). Percent and absolute number of Foxp3+ T regulatory cells (Treg) were evaluated in the spleen (d) and suppressive assays were performed by isolating and adding Treg at a different ratio into collagen-specific cultures and responder T cell proliferation was assessed (e). Data are shown as mean ± SEM from one experiment (d Kruskal-Wallis test ANOVA with Dunn’s multiple comparisons test; e Friedman test ANOVA with Dunn’s multiple comparisons test). Plasmacytoid dendritic cells (pDC), conventional dendritic cells (cDC) and macrophages (macro) were isolated and cultured with naïve allogenic T cells to determine Treg polarization (f), and their response to TLR ligand was assessed through evaluation of CD40 costimulatory molecule expression (g). Data from individual mouse plus mean (black bar) from one experiment representative of four are shown; *p < 0.05, ***p < 0.001 (f ordinary one-way ANOVA with Tukey’s multiple comparisons test; g Kruskal-Wallis test ANOVA with Dunn’s multiple comparisons test). BrDU 5-Bromo-2’-deoxyuridine Image collected and cropped by CiteAb from the following publication (//arthritis-research.biomedcentral.com/articles/10.1186/s13075-016-1084-0), licensed under a CC-BY license. Not internally tested by R&D Systems." /> </a> </div> <div class="alt-caption padding_left5" >Apoptotic cell-induced immunomodulation in mice with collagen-induced arthritis (CIA) is dependent on transforming growth factor (TGF)-beta . CIA mice that received or did not receive apoptotic cells, with or without<a class="openGallery" href="#" data-picnum="1"> ...read more</a></div> </div> <div class="big_thumb_container"> <div class="image_wrapper"> <a href="//images.novusbio.com/fullsize/mab1835_tgf-beta-1-2-3-mab-clone-1d11-4120241033416.jpg" class="top_images" rel="gallery" title="TGF beta 1 stimulates the expression of ECM components in human and rabbit primary cells. (A) Selected ECM mRNA transcripts were measured using qRT-PCR in human RPTEC or human IPF134 following 48 hr stimulation with TGF beta 1 (10 ng/mL). Data show transcript abundance relative to the unstimulated control (indicated by the dashed line) and are shown as mean ± SD of four (RPTEC) or seven (IPF134) independent experiments. ****P < 0.0001; ****P < 0.001; **P < 0.01; Student’s t-test. (B) The accumulation of ECM in human RPTEC (i) or human IPF (ii) cells stimulated with 10ng/mL TGF beta 1 was evaluated via measurement of the incorporation of 14C-labelled amino acids into the deposited ECM. Data presented are the mean ± SD of three independent experiments. **P < 0.01; Student’s t-test. (C) Increased mature ECM accumulation following treatment of cells with a pro-fibrotic stimulus can be visualised following in-situ fluorescent staining using the Flamingo dye. Cells from three different systems (primary human RPTEC; primary human IPF134; co-culture of primary rabbit RPTEC with primary rabbit renal fibroblasts) were cultured in the absence (top) or presence (bottom) of 10 ng/ml TGF beta 1 before decellularised matrix was fixed and stained in situ with Flamingo fluorescent dye. Images show a single field. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28855577), licensed under a CC-BY license. Not internally tested by R&D Systems." > <img src="//images.novusbio.com/images/mab1835_tgf-beta-1-2-3-mab-clone-1d11-4120241033416.jpg" loading="lazy" style="display:none;" class="big_thumb" alt="TGF beta 1 stimulates the expression of ECM components in human and rabbit primary cells. (A) Selected ECM mRNA transcripts were measured using qRT-PCR in human RPTEC or human IPF134 following 48 hr stimulation with TGF beta 1 (10 ng/mL). Data show transcript abundance relative to the unstimulated control (indicated by the dashed line) and are shown as mean ± SD of four (RPTEC) or seven (IPF134) independent experiments. ****P < 0.0001; ****P < 0.001; **P < 0.01; Student’s t-test. (B) The accumulation of ECM in human RPTEC (i) or human IPF (ii) cells stimulated with 10ng/mL TGF beta 1 was evaluated via measurement of the incorporation of 14C-labelled amino acids into the deposited ECM. Data presented are the mean ± SD of three independent experiments. **P < 0.01; Student’s t-test. (C) Increased mature ECM accumulation following treatment of cells with a pro-fibrotic stimulus can be visualised following in-situ fluorescent staining using the Flamingo dye. Cells from three different systems (primary human RPTEC; primary human IPF134; co-culture of primary rabbit RPTEC with primary rabbit renal fibroblasts) were cultured in the absence (top) or presence (bottom) of 10 ng/ml TGF beta 1 before decellularised matrix was fixed and stained in situ with Flamingo fluorescent dye. Images show a single field. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28855577), licensed under a CC-BY license. Not internally tested by R&D Systems." title="TGF beta 1 stimulates the expression of ECM components in human and rabbit primary cells. (A) Selected ECM mRNA transcripts were measured using qRT-PCR in human RPTEC or human IPF134 following 48 hr stimulation with TGF beta 1 (10 ng/mL). Data show transcript abundance relative to the unstimulated control (indicated by the dashed line) and are shown as mean ± SD of four (RPTEC) or seven (IPF134) independent experiments. ****P < 0.0001; ****P < 0.001; **P < 0.01; Student’s t-test. (B) The accumulation of ECM in human RPTEC (i) or human IPF (ii) cells stimulated with 10ng/mL TGF beta 1 was evaluated via measurement of the incorporation of 14C-labelled amino acids into the deposited ECM. Data presented are the mean ± SD of three independent experiments. **P < 0.01; Student’s t-test. (C) Increased mature ECM accumulation following treatment of cells with a pro-fibrotic stimulus can be visualised following in-situ fluorescent staining using the Flamingo dye. Cells from three different systems (primary human RPTEC; primary human IPF134; co-culture of primary rabbit RPTEC with primary rabbit renal fibroblasts) were cultured in the absence (top) or presence (bottom) of 10 ng/ml TGF beta 1 before decellularised matrix was fixed and stained in situ with Flamingo fluorescent dye. Images show a single field. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28855577), licensed under a CC-BY license. Not internally tested by R&D Systems." /> </a> </div> <div class="alt-caption padding_left5" >TGF beta 1 stimulates the expression of ECM components in human and rabbit primary cells. (A) Selected ECM mRNA transcripts were measured using qRT-PCR in human RPTEC or human IPF134 following 48 hr stimulation with<a class="openGallery" href="#" data-picnum="2"> ...read more</a></div> </div> <div class="big_thumb_container"> <div class="image_wrapper"> <a href="//images.novusbio.com/fullsize/mab1835_tgf-beta-1-2-3-mab-clone-1d11-22820241723624.jpg" class="top_images" rel="gallery" title="CBirTox induced expression of Foxp3 is dependent on TGF-beta but independent of RA signaling.(A) CD11c+ DCs were isolated from the spleen, MLN or LP and pulsed with 1 μg/ml of CBirTox or CBir1 peptide for 2 hours prior to co-culture with CD4+ CBir1 Tg T cells for 4 days before flow cytometry analysis. Results represent 2–3 independent experiments (B-C) CD11c+ DCs were isolated from the spleen and pulsed with 1 μg/ml of CBirTox for 1 hour before co-culture with CD4+ CBir1 Tg T cells in the presence of 1 μM of the RA inhibitor LE135 or RA for 4 days. Representative flow plots (B) of 3 independent experiments (C) are shown. (D-E) Splenic CD19+ B cells were pulsed with 2 μg of CBirTox for 2 hours before co-culture with with CD4+ CBir1 Tg T cells with or without the presence of 10 μg/ml anti-TGF-beta (1,2,3) for 4 days prior to flow cytometry analysis. Representative flow plots (D) of 4–5 independent experiments (E) are shown. Results of all experiments are expressed as the mean ± SEM. ***p<0.0005, NS, not significant. Groups of three or more were analyzed using one-way ANOVA with Bonferroni’s post test. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28750075), licensed under a CC-BY license. Not internally tested by R&D Systems." > <img src="//images.novusbio.com/images/mab1835_tgf-beta-1-2-3-mab-clone-1d11-22820241723624.jpg" loading="lazy" style="display:none;" class="big_thumb" alt="CBirTox induced expression of Foxp3 is dependent on TGF-beta but independent of RA signaling.(A) CD11c+ DCs were isolated from the spleen, MLN or LP and pulsed with 1 μg/ml of CBirTox or CBir1 peptide for 2 hours prior to co-culture with CD4+ CBir1 Tg T cells for 4 days before flow cytometry analysis. Results represent 2–3 independent experiments (B-C) CD11c+ DCs were isolated from the spleen and pulsed with 1 μg/ml of CBirTox for 1 hour before co-culture with CD4+ CBir1 Tg T cells in the presence of 1 μM of the RA inhibitor LE135 or RA for 4 days. Representative flow plots (B) of 3 independent experiments (C) are shown. (D-E) Splenic CD19+ B cells were pulsed with 2 μg of CBirTox for 2 hours before co-culture with with CD4+ CBir1 Tg T cells with or without the presence of 10 μg/ml anti-TGF-beta (1,2,3) for 4 days prior to flow cytometry analysis. Representative flow plots (D) of 4–5 independent experiments (E) are shown. Results of all experiments are expressed as the mean ± SEM. ***p<0.0005, NS, not significant. Groups of three or more were analyzed using one-way ANOVA with Bonferroni’s post test. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28750075), licensed under a CC-BY license. Not internally tested by R&D Systems." title="CBirTox induced expression of Foxp3 is dependent on TGF-beta but independent of RA signaling.(A) CD11c+ DCs were isolated from the spleen, MLN or LP and pulsed with 1 μg/ml of CBirTox or CBir1 peptide for 2 hours prior to co-culture with CD4+ CBir1 Tg T cells for 4 days before flow cytometry analysis. Results represent 2–3 independent experiments (B-C) CD11c+ DCs were isolated from the spleen and pulsed with 1 μg/ml of CBirTox for 1 hour before co-culture with CD4+ CBir1 Tg T cells in the presence of 1 μM of the RA inhibitor LE135 or RA for 4 days. Representative flow plots (B) of 3 independent experiments (C) are shown. (D-E) Splenic CD19+ B cells were pulsed with 2 μg of CBirTox for 2 hours before co-culture with with CD4+ CBir1 Tg T cells with or without the presence of 10 μg/ml anti-TGF-beta (1,2,3) for 4 days prior to flow cytometry analysis. Representative flow plots (D) of 4–5 independent experiments (E) are shown. Results of all experiments are expressed as the mean ± SEM. ***p<0.0005, NS, not significant. Groups of three or more were analyzed using one-way ANOVA with Bonferroni’s post test. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28750075), licensed under a CC-BY license. Not internally tested by R&D Systems." /> </a> </div> <div class="alt-caption padding_left5" >CBirTox induced expression of Foxp3 is dependent on TGF-beta but independent of RA signaling.(A) CD11c+ DCs were isolated from the spleen, MLN or LP and pulsed with 1 μg/ml of CBirTox or CBir1 peptide for 2 hours<a class="openGallery" href="#" data-picnum="3"> ...read more</a></div> </div> <div class="big_thumb_container"> <div class="image_wrapper"> <a href="//images.novusbio.com/fullsize/mab1835_tgf-beta-1-2-3-mab-clone-1d11-8120255531676.jpg" class="top_images" rel="gallery" title="Expression of genes involved in fibrosis at 6 months.(A) IHC and ISH (inlets) showing MMP9 expression in proliferating myofibroblasts and ductular cells. (B) IHC for TGF beta 1. Contrary to MMP9, TGF beta 1 is expressed only in proliferating ductular cells which are also positive for cytokeratin. (C, D) ISH for PDGFAa and IL1b. Transcripts of both genes are detected in a small subset of proliferating myofibroblasts and ductular cells. (A–C, red arrowheads, ductular cells). Microscopic images are 400×. Bars, 50 µm. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/22164219), licensed under a CC-BY license. Not internally tested by R&D Systems." > <img src="//images.novusbio.com/images/mab1835_tgf-beta-1-2-3-mab-clone-1d11-8120255531676.jpg" loading="lazy" style="display:none;" class="big_thumb" alt="Expression of genes involved in fibrosis at 6 months.(A) IHC and ISH (inlets) showing MMP9 expression in proliferating myofibroblasts and ductular cells. (B) IHC for TGF beta 1. Contrary to MMP9, TGF beta 1 is expressed only in proliferating ductular cells which are also positive for cytokeratin. (C, D) ISH for PDGFAa and IL1b. Transcripts of both genes are detected in a small subset of proliferating myofibroblasts and ductular cells. (A–C, red arrowheads, ductular cells). Microscopic images are 400×. Bars, 50 µm. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/22164219), licensed under a CC-BY license. Not internally tested by R&D Systems." title="Expression of genes involved in fibrosis at 6 months.(A) IHC and ISH (inlets) showing MMP9 expression in proliferating myofibroblasts and ductular cells. (B) IHC for TGF beta 1. Contrary to MMP9, TGF beta 1 is expressed only in proliferating ductular cells which are also positive for cytokeratin. (C, D) ISH for PDGFAa and IL1b. Transcripts of both genes are detected in a small subset of proliferating myofibroblasts and ductular cells. (A–C, red arrowheads, ductular cells). Microscopic images are 400×. Bars, 50 µm. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/22164219), licensed under a CC-BY license. Not internally tested by R&D Systems." /> </a> </div> <div class="alt-caption padding_left5" >Expression of genes involved in fibrosis at 6 months.(A) IHC and ISH (inlets) showing MMP9 expression in proliferating myofibroblasts and ductular cells. (B) IHC for TGF beta 1. Contrary to MMP9, TGF beta 1 is expressed<a class="openGallery" href="#" data-picnum="4"> ...read more</a></div> </div></div><div id="ss_next_top" class="cycle-pager"><div class="pager_right_on"></div></div></div></div><div class="productsright pos_relative equaltop"><h2 class="blueHead">Product Details</h2> <div class="midBlue">Summary</div><table class="ds_list"><tr class="lined"> <td><strong>Reactivity</strong></td> <td><span title='Multi-Species'>All-Multi</span><span class="myModal">Species Glossary</span></td> </tr><tr class="lined"> <td><strong>Applications</strong></td> <td><span title='Western Blot'>WB</span>, <span title='Block/Neutralize'>B/N</span>, <span title='ELISA Capture'>ELISA(Cap)</span></td> </tr><tr class="lined"> <td><strong>Clone</strong></td> <td><div>1D11</div></td> </tr><tr class="lined"> <td><strong>Clonality</strong></td> <td><div>Monoclonal</div></td> </tr><tr class="lined"> <td><strong>Host</strong></td> <td><div>Mouse</div></td> </tr><tr class="lined"> <td><strong>Conjugate</strong></td> <td><div>Unconjugated</div></td> </tr></table></div> </div></div><div class="grid_6"><div></div> <div class="ds_blue_border equaltop"> <h2 class="blueHead_nopadding">Order Details</h2><ul class="ds_details"><li class="add-to-cart" data-type="full" data-prodname="TGF-beta 1,-2,-3 MAb (Clone 1D11)" data-catnum="MAB1835" data-catnums="MAB1835-SP,MAB1835-100,MAB1835-500" data-disabled=''><noscript><form autocomplete="off" action="https://www.google.com/" method="post" id="et-add-multiple-to-cart-form" accept-charset="UTF-8"><div><table class="sticky-enabled"> <thead><tr><th>Size / Catalog#</th><th>Qty</th><th>Price</th> </tr></thead> <tbody> <tr class="odd"><td><div data-msg='' class="atc_catnum">MAB1835-SP</div><div class="atc_size" title="catalog # MAB1835-SP">25 ug</div></td><td><div class="form-item form-type-textfield form-item-rows-MAB1835-SP-quantity"> <input type="text" id="edit-rows-mab1835-sp-quantity" name="rows[MAB1835-SP][quantity]" value="" size="60" maxlength="2" class="form-text" /> </div> </td><td><div class="price"> $169.00</div></td> </tr> <tr class="even"><td colspan="3" class="stock_row">In Stock: 5-7 Business Days</td> </tr> <tr class="odd"><td><div data-msg='' class="atc_catnum">MAB1835-100</div><div class="atc_size" title="catalog # MAB1835-100">100 ug</div></td><td><div class="form-item form-type-textfield form-item-rows-MAB1835-100-quantity"> <input type="text" id="edit-rows-mab1835-100-quantity" name="rows[MAB1835-100][quantity]" value="" size="60" maxlength="2" class="form-text" /> </div> </td><td><div class="price"> $469.00</div></td> </tr> <tr class="even"><td colspan="3" class="stock_row">In Stock: 5-7 Business Days</td> </tr> <tr class="odd"><td><div data-msg='' class="atc_catnum">MAB1835-500</div><div class="atc_size" title="catalog # MAB1835-500">500 ug</div></td><td><div class="form-item form-type-textfield form-item-rows-MAB1835-500-quantity"> <input type="text" id="edit-rows-mab1835-500-quantity" name="rows[MAB1835-500][quantity]" value="" size="60" maxlength="2" class="form-text" /> </div> </td><td><div class="price"> $1,879.00</div></td> </tr> <tr class="even"><td colspan="3" class="stock_row">In Stock: 5-7 Business Days</td> </tr> </tbody> </table> <input class="bulk_custom iframeBulkQuote form-submit" onClick="window.location.assign("https://www.novusbio.com/novus_quoterequest?mlt=TGF-beta1%2C+2%2C+3+Antibody&catnum=MAB1835"); return false;" type="submit" id="edit-bulk-request" name="op" value="Bulk Request" /><input class="add_to_cart form-submit" type="submit" id="edit-add-multiple-to-cart" name="op" value="Add To Cart " /><input type="hidden" name="form_build_id" value="form-AQigKH5cps38KYrX75Sa2wxPz0-6mZMNnHwxs-eN7dw" /> <input type="hidden" name="form_id" value="et_add_multiple_to_cart_form" /> </div></form></noscript></li></ul><div id="shipping" class="hidden"></td></tr></div><div class="conj_form_buttons"><div class="list_expand options_closed" data-name="Conjugates" data-wrapper-type=".conjugates_wrapper"><div class="options_text">View Available Conjugates</div> <div class="expander option_closed"></div></div><div class="conjugates_wrapper" data-title="TGF beta 1/2/3 Antibody (1D11) [Unconjugated]" data-catnum="MAB1835"><table class="scf_table"> <thead> <tr> <th>Catalog# & Conjugate</th> <th>Size</th> <th class="col_price">Price</th> <th class="col_cart hidden"></th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="FAB1835U"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835u" class="conj_link">Alexa Fluor 350</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835u" class="cat_link">FAB1835U</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965796"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835V"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835v" class="conj_link">Alexa Fluor 405</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835v" class="cat_link">FAB1835V</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965781"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835G"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835g" class="conj_link">Alexa Fluor 488</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835g" class="cat_link">FAB1835G</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/983641"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835X"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835x" class="conj_link">Alexa Fluor 532</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835x" class="cat_link">FAB1835X</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965799"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835T"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835t" class="conj_link">Alexa Fluor 594</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835t" class="cat_link">FAB1835T</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965797"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835R"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835r" class="conj_link">Alexa Fluor 647</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835r" class="cat_link">FAB1835R</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965782"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835N"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835n" class="conj_link">Alexa Fluor 700</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835n" class="cat_link">FAB1835N</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/1242410"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835S"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835s" class="conj_link">Alexa Fluor 750</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835s" class="cat_link">FAB1835S</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965798"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835A"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835a" class="conj_link">Allophycocyanin</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835a" class="cat_link">FAB1835A</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/1242411"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835B"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835b" class="conj_link">Biotin</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835b" class="cat_link">FAB1835B</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965783"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835CL1"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835cl1" class="conj_link">CoraFluor 1</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835cl1" class="cat_link">FAB1835CL1</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/1311157"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835D"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835d" class="conj_link">DyLight 350</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835d" class="cat_link">FAB1835D</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965784"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835E"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835e" class="conj_link">DyLight 405</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835e" class="cat_link">FAB1835E</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965785"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835K"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835k" class="conj_link">DyLight 488</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835k" class="cat_link">FAB1835K</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965786"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835L"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835l" class="conj_link">DyLight 550</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835l" class="cat_link">FAB1835L</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965787"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835M"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835m" class="conj_link">DyLight 594</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835m" class="cat_link">FAB1835M</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965788"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835W"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835w" class="conj_link">DyLight 650</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835w" class="cat_link">FAB1835W</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965789"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835Y"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835y" class="conj_link">DyLight 680</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835y" class="cat_link">FAB1835Y</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965790"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835Z"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835z" class="conj_link">DyLight 755</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835z" class="cat_link">FAB1835Z</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965791"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835F"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835f" class="conj_link">FITC</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835f" class="cat_link">FAB1835F</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965792"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835H"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835h" class="conj_link">HRP</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835h" class="cat_link">FAB1835H</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965793"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835JF525"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835jf525" class="conj_link">Janelia Fluor 525</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835jf525" class="cat_link">FAB1835JF525</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/1382732"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835I"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835i" class="conj_link">Janelia Fluor 549</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835i" class="cat_link">FAB1835I</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965794"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835J"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835j" class="conj_link">Janelia Fluor 646</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835j" class="cat_link">FAB1835J</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/965795"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835JF669"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835jf669" class="conj_link">Janelia Fluor 669</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835jf669" class="cat_link">FAB1835JF669</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/1382735"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835C"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835c" class="conj_link">PerCP</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835c" class="cat_link">FAB1835C</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/1242414"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835MFV450"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835mfv450" class="conj_link">mFluor Violet 450 SE</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835mfv450" class="cat_link">FAB1835MFV450</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/1242415"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835MFV500"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835mfv500" class="conj_link">mFluor Violet 500 SE</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835mfv500" class="cat_link">FAB1835MFV500</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/1242416"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835MFV610"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835mfv610" class="conj_link">mFluor Violet 610 SE</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835mfv610" class="cat_link">FAB1835MFV610</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart hidden"><a href="/commerce/add-to-cart/1242417"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr> <tr class="scf_footer"> <td colspan="4"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["FAB1835U","FAB1835V","FAB1835G","FAB1835X","FAB1835T","FAB1835R","FAB1835N","FAB1835S","FAB1835A","FAB1835B","FAB1835CL1","FAB1835D","FAB1835E","FAB1835K","FAB1835L","FAB1835M","FAB1835W","FAB1835Y","FAB1835Z","FAB1835F","FAB1835H","FAB1835JF525","FAB1835I","FAB1835J","FAB1835JF669","FAB1835C","FAB1835MFV450","FAB1835MFV500","FAB1835MFV610"]' data-rendered="false"></div></div><div class="list_expand options_closed" data-name="Formulations" data-wrapper-type=".formulations_wrapper"><div class="options_text">View Available Formulations</div> <div class="expander option_closed"></div></div><div class="formulations_wrapper" data-title="TGF beta 1/2/3 Antibody (1D11) [Unconjugated]" data-catnum="MAB1835"><table class="scf_table"> <thead> <tr> <th>Catalog# & Formulation</th> <th>Size</th> <th class="col_price">Price</th> <th class="col_cart"></th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="MAB1835-SP"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_mab1835" class="conj_link">Carrier Free</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_mab1835" class="cat_link">MAB1835-SP</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart"><a href="/commerce/add-to-cart/432475"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr><tr class="popup_sku" data-sku="MAB1835-500"> <td> <a href="/products/tgf-beta-1-2-3-antibody-1d11_mab1835" class="conj_link">Carrier Free</a><br /> <a href="/products/tgf-beta-1-2-3-antibody-1d11_mab1835" class="cat_link">MAB1835-500</a> </td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> <td class="col_cart"><a href="/commerce/add-to-cart/465118"><div class="purchase_cart"></div></a></td> </tr> <tr> <td colspan="4" class="row_stock"><div class="popup_stock"></div></td> </tr> <tr class="scf_footer"> <td colspan="4"><div class="expander option_opened"></div></td> </tr> </tbody> </table> <div class="popup_skus" data-skus='["MAB1835-SP","MAB1835-500"]' data-rendered="false"></div></div></div><div id="shipping_statement"><span id="shipping_rate"></span></div><div class="shipping_obt_transfer"><span>Novus Biologicals is part of Bio-Techne</span><br><br><a href="https://www.bio-techne.com/p/antibodies/tgf-beta1-2-3-antibody-1d11_mab1835" rel="follow" class="btn btn-primary">Shop this product on bio-techne.com</a></div><br><div class="learn_more"> <a href="/guarantee"> <div class="sprite_noImage" title="Novus Biologicals, part of Bio-Techne, offers 100% Guarantee"></div> <div class="learn_more_text">Novus Biologicals, part of Bio-Techne, offers 100% Guarantee</div></a> </div><span id="conj_form" class="hidden"><tr><td colspan="4"><table class="scf_table"> <thead> <tr> <th>Conjugate</th> <th>Catalog #</th> <th class="head_avail">Availability</th> <th>Size</th> <th class="col_price">Price</th> </tr> </thead> <tbody><tr class="popup_sku" data-sku="FAB1835U"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835u">Alexa Fluor 350</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835u">FAB1835U</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835V"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835v">Alexa Fluor 405</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835v">FAB1835V</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835G"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835g">Alexa Fluor 488</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835g">FAB1835G</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835X"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835x">Alexa Fluor 532</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835x">FAB1835X</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835T"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835t">Alexa Fluor 594</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835t">FAB1835T</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835R"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835r">Alexa Fluor 647</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835r">FAB1835R</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835N"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835n">Alexa Fluor 700</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835n">FAB1835N</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835S"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835s">Alexa Fluor 750</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835s">FAB1835S</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835A"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835a">Allophycocyanin</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835a">FAB1835A</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835B"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835b">Biotin</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835b">FAB1835B</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835CL1"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835cl1">CoraFluor 1</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835cl1">FAB1835CL1</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835D"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835d">DyLight 350</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835d">FAB1835D</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835E"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835e">DyLight 405</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835e">FAB1835E</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835K"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835k">DyLight 488</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835k">FAB1835K</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835L"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835l">DyLight 550</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835l">FAB1835L</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835M"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835m">DyLight 594</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835m">FAB1835M</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835W"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835w">DyLight 650</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835w">FAB1835W</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835Y"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835y">DyLight 680</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835y">FAB1835Y</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835Z"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835z">DyLight 755</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835z">FAB1835Z</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835F"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835f">FITC</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835f">FAB1835F</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835H"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835h">HRP</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835h">FAB1835H</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835JF525"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835jf525">Janelia Fluor 525</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835jf525">FAB1835JF525</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835I"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835i">Janelia Fluor 549</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835i">FAB1835I</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835J"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835j">Janelia Fluor 646</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835j">FAB1835J</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835JF669"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835jf669">Janelia Fluor 669</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835jf669">FAB1835JF669</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835C"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835c">PerCP</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835c">FAB1835C</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835MFV450"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835mfv450">mFluor Violet 450 SE</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835mfv450">FAB1835MFV450</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835MFV500"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835mfv500">mFluor Violet 500 SE</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835mfv500">FAB1835MFV500</a></td> <td><div class="popup_stock"></div></td> <td><div class="popup_size"></div></td> <td class="col_price"><div class="popup_price"></div></td> </tr><tr class="popup_sku" data-sku="FAB1835MFV610"> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835mfv610">mFluor Violet 610 SE</a></td> <td><a href="/products/tgf-beta-1-2-3-antibody-1d11_fab1835mfv610">FAB1835MFV610</a></td> <td><div class="popup_stock"></div></td> <td><div 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id="dsTabs_protocols-faqs" data-anchor_desc="protocols-faqs">Protocols & FAQs</div> <div class="ds_tab" id="dsTabs_supportresearch" data-anchor_desc="supportresearch">Support & Research</div> </div><div class="ds_tab_content equalbottom" id="content_datasheet" > <a id="datasheet"></a><h2 class=greyHead2>TGF beta 1/2/3 Antibody (1D11) [Unconjugated] Summary</h2> <div class="ds_info"> <a id="tab1details"></a> <table class="ds_list wide" style="table-layout:fixed;"> <tr class="lined"> <td><strong>Immunogen</strong></td> <td><div>Bovine bone-derived TGF-beta 1 and TGF-beta 2</div></td> </tr><tr class="lined"> <td><strong>Specificity</strong></td> <td><div>Detects bovine, chicken, mouse, and human TGF-beta in ELISAs and Western blots. It recognizes human TGF-beta 1, TGF-beta 2, and TGF-beta 3. No cross-reactivity was observed with recombinant LAP in direct ELISAs.</div></td> </tr><tr class="lined"> <td><strong>Source</strong></td> <td><div>N/A</div></td> </tr><tr class="lined"> <td><strong>Isotype</strong></td> <td><div>IgG1</div></td> </tr><tr class="lined"> <td><strong>Clonality</strong></td> <td><div>Monoclonal</div></td> </tr><tr class="lined"> <td><strong>Host</strong></td> <td><div>Mouse</div></td> </tr><tr class="lined"> <td><strong>Gene</strong></td> <td><div>TGFB1</div></td> </tr><tr class="lined"> <td><strong>Purity Statement</strong></td> <td><div>Protein A or G purified from hybridoma culture supernatant</div></td> </tr><tr class="lined"> <td><strong>Endotoxin Note</strong></td> <td><div><0.10 EU per 1 μg of the antibody by the LAL method.</div></td> </tr><tr class="lined"> <td><strong>Innovator's Reward</strong></td> <td><div>Test in a species/application not listed above to receive a full credit towards a future purchase.<br/><div class='text_right'><a class='ds_submit_blue ds_regularPad' href='/support/innovators-reward.html'>Learn about the Innovator's Reward</a></div></div></td> </tr> </table> </div> <h2 class="greyHead2">Applications/Dilutions</h2> <div class="ds_info"> <a id="tab1appsdiluts"></a> <table class="ds_list wide"> <tr class="lined"> <td><strong>Dilutions</strong></td> <td> <ul class="ds_noDotList"><li>Binding Inhibition </li><li>ELISA Capture (Matched Antibody Pair) 2-8 ug/mL</li><li>ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL</li><li>ELISA Standard (Matched Pair) </li><li>Neutralization 0.25-1.25 ug/mL</li><li>Western Blot 1 ug/mL</li> </ul> </td> </tr><tr class="lined"> <td><strong>Application Notes</strong></td> <td><div>ELISA Detection: TGF-beta 1 Biotinylated Antibody (Catalog number BAF240)<br>Standard: Recombinant Human TGF-beta 1 (Catalog number 240-B)</div></td> </tr><tr class="lined"> <td><strong>Publications</strong></td> <td> <table> <tr> <td>Read <a href="#PublicationSection"> Publications</a> using<br/> MAB1835 in the following applications:<br /><br /> <ul class="information-list"><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Activation">Activation</a> </div><div class="information-data">1 publication</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Agonist Activity">Agonist Activity</a> </div><div class="information-data">1 publication</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Bioassay">Bioassay</a> </div><div class="information-data">11 publications</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Blocking">Blocking</a> </div><div class="information-data">1 publication</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Co-IP">Co-IP</a> </div><div class="information-data">1 publication</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Dot Blot">Dot Blot</a> </div><div class="information-data">1 publication</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="ELISA Capture">ELISA Capture</a> </div><div class="information-data">2 publications</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="ELISA Development">ELISA Development</a> </div><div class="information-data">1 publication</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="ELISA Development (Capture)">ELISA Development (Capture)</a> </div><div class="information-data">1 publication</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Flow Cytometry">Flow Cytometry</a> </div><div class="information-data">7 publications</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Functional Assay">Functional Assay</a> </div><div class="information-data">1 publication</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="ICC">ICC</a> </div><div class="information-data">4 publications</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="IHC">IHC</a> </div><div class="information-data">3 publications</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="IHC-Fr">IHC-Fr</a> </div><div class="information-data">3 publications</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="IHC-P">IHC-P</a> </div><div class="information-data">2 publications</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Immunodepletion">Immunodepletion</a> </div><div class="information-data">1 publication</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="In Vivo">In Vivo</a> </div><div class="information-data">2 publications</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Luminex Development">Luminex Development</a> </div><div class="information-data">1 publication</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Neutralization">Neutralization</a> </div><div class="information-data">120 publications</div></li><li class="noIndent"><div class="information-subject"> <a href="#PublicationSection" class="filter_link" data-destination="publication" data-type="application" data-filter="Western Blot">Western Blot</a> </div><div class="information-data">13 publications</div></li></ul></td> </tr> </table> </td> </tr> </table> </div> <h2 class="greyHead2">Packaging, Storage & Formulations</h2><div class="ds_info"><table class="ds_list"><tr class="lined"> <td><strong>Storage</strong></td> <td><div><b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles. </b><UL><LI>12 months from date of receipt, -20 to -70 °C as supplied.</LI><LI>1 month, 2 to 8 °C under sterile conditions after reconstitution.</LI><LI>6 months, -20 to -70 °C under sterile conditions after reconstitution.</LI></UL></div></td> </tr><tr class="lined"> <td><strong>Buffer</strong></td> <td><div>Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.</div></td> </tr><tr class="lined"> <td><strong>Preservative</strong></td> <td><div>No Preservative</div></td> </tr><tr class="lined"> <td><strong>Reconstitution Instructions</strong></td> <td><div>Reconstitute at 0.5 mg/mL in sterile PBS.</div></td> </tr></table></div> <h2 class="greyHead2">Notes</h2><div class="ds_info"> <a id="tab1notes"></a> <div>This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.</div> </div><h2 class="greyHead2">Alternate Names for TGF beta 1/2/3 Antibody (1D11) [Unconjugated]</h2> <div class="ds_info"> <a id="tab1altnames"></a> <div class="information-list"> <ul><li>CED</li><li>DPD1</li><li>LAP</li><li>TGFB</li><li>TGFB1</li><li>TGF-beta 1, 2, 3</li><li>TGFbeta</li><li>transforming growth factor, beta 1</li></ul></div> </div> <h2 class="greyHead2">Background</h2> <div class="ds_info"> <a id="tab1background"></a> <div>TGF-beta 1, -2, and -3 are a closely related group of proteins (70‑80% sequence homology) that are produced by many cell types and function as growth and differentiation factors. The active forms of TGF-beta 1, -2, and -3 are disulfide-linked homodimers.<div class="backref"><OL> <LI>Ayala A. <EM>et al.</EM> (1992) FASEB J. <STRONG>6</STRONG>:A1604.</LI> <LI>Roberts A.B. and Sporn M.B., eds. (1990) Peptide Growth Factors and Their Receptors I, Springer-Verlag, 419.</LI> <LI>Dasch J.R. <EM>et al.</EM> (1989) J. Immunol. <STRONG>142</STRONG>:1536.</LI></OL></div></div> </div> <h2 class="greyHead2">Limitations</h2> <div class="ds_info"> <a id="tab1background"></a> <div>This product is for research use only and is not approved for use in humans or in clinical diagnosis. 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PVDF membrane was probed with 0.5 µg/mL Goat Anti-Human/Mouse Smad2/3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3797) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). For additional reference, recombinant human Smad2 and Smad3 were included. Specific bands for Smad2 were detected at approximately 64 and 58 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2." class="cust_viewed_3" > <img loading="lazy" src="https://images.novusbio.com/images2/Smad3_AF3797_Western_Blot_5347.jpg" alt="Western Blot Smad2/3 Antibody [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/smad2-3-antibody_af3797" title="Jurkat human acute T cell leukemia cell line treated with 50 ng/mL PMA and 200 ng/mL calcium ionomycin for 30 minutes was fixed using formaldehyde, resuspended in lysis buffer, and sonicated to shear chromatin. Smad2/3/DNA complexes were immunoprecipitated using 5 μg Goat Anti-Human/Mouse Smad2/3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3797) or control antibody (Catalog&amp;nbsp;# AB‑108‑C) for 15&amp;nbsp;minutes in an ultrasonic bath, followed by Biotinylated Anti-Goat IgG Secondary Antibody (Catalog&amp;nbsp;# BAF109). Immunocomplexes were captured using 50 μL of MagCellect Streptavidin Ferrofluid (Catalog&amp;nbsp;# MAG999) and DNA was purified using chelating resin solution. The c-myc promoter was detected by standard PCR." class="cust_viewed_3" > <img loading="lazy" src="https://images.novusbio.com/images2/Smad3_AF3797_Chromatin_Immunoprecipitation_11240.jpg" alt="Chromatin Immunoprecipitation (ChIP) Smad2/3 Antibody [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/smad2-3-antibody_af3797" title="Smad2/3 was detected in immersion fixed MCF-7 human breast cancer cell line induced (upper panel) or non-induced (lower panel) to undergo epithelial-mesenchymal transition (EMT) using Goat Anti-Human/Mouse Smad2/3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3797) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights&amp;#8482; 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm and, in EMT-induced cells, nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="cust_viewed_3" > <img loading="lazy" src="https://images.novusbio.com/images2/Smad3_AF3797_Immunocytochemistry_11829.jpg" alt="Immunocytochemistry Smad2/3 Antibody [Unconjugated]" class="big_thumb" /> </a> </div></div><div id="ss_next_cav3" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-3" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/smad2-3-antibody_af3797#ReviewsSection"> <div class="sprite_4Stars"></div> (1 Review</a>) </div> <div class="tiny"> <a href="/products/smad2-3-antibody_af3797#PublicationSection"> <div class="sprite_pubBook"></div> (24 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu, Mu</div><div class="tiny"><strong>Applications:</strong> ChIP, ICC, IHC, Simple Western, WB</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="NB100-56479"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/smad3-antibody_nb100-56479" style="overflow: hidden; width: 280px;" title="Smad3 Antibody">Smad3 Antibody</a>    </div><div class="sub-header">NB100-56479</div> <div class="images_customers"><div id="ss_prev_cav4" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-4" data-cycle-prev="#ss_prev_cav4" data-cycle-next="#ss_next_cav4" data-cycle-slides="div.big_thumb_cust_container" data-index=4 ><div class="big_thumb_cust_container"> <a href="/products/smad3-antibody_nb100-56479" title="Immunocytochemistry/Immunofluorescence: Smad3 Antibody [NB100-56479] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X PBS + 0.5% Triton X-100. The cells were incubated with anti-Smad3 at 10 ug/mL overnight at 4C and detected with an anti-rabbit DyLight 488 (Green) at a 1:500 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective." class="cust_viewed_4" > <img loading="lazy" src="https://images.novusbio.com/images/Smad3-Antibody-Immunocytochemistry-Immunofluorescence-NB100-56479-img0006.jpg" alt="Immunocytochemistry/ Immunofluorescence Smad3 Antibody" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/smad3-antibody_nb100-56479" title="Western Blot: Smad3 Antibody [NB100-56479] - Analysis in human fibroblast and HeLa whole cell lysates. Untreated lysates show a band around 55 kDa. 1:1000 dilution, 1 hour blocking in milk 5%. WB image submitted by a verified customer review." class="cust_viewed_4" > <img loading="lazy" src="https://images.novusbio.com/images/Smad3-Antibody-Western-Blot-NB100-56479-img0008.jpg" alt="Western Blot Smad3 Antibody" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/smad3-antibody_nb100-56479" title="Immunohistochemistry-Paraffin: Smad3 Antibody [NB100-56479] - Human liver tissue probed with SMAD3 antibody (bottom left, right) and isotype control antibody (top left) at 10 ug/mL." class="cust_viewed_4" > <img loading="lazy" src="https://images.novusbio.com/images/Smad3-Antibody-Immunohistochemistry-Paraffin-NB100-56479-img0004.jpg" alt="Immunohistochemistry-Paraffin Smad3 Antibody" class="big_thumb" /> </a> </div></div><div id="ss_next_cav4" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-4" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/smad3-antibody_nb100-56479#ReviewsSection"> <div class="sprite_3Stars"></div> (5 Reviews</a>) </div> <div class="tiny"> <a href="/products/smad3-antibody_nb100-56479#PublicationSection"> <div class="sprite_pubBook"></div> (8 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Bv, Ca, Hu, Mu, Po, Pm, Rt</div><div class="tiny"><strong>Applications:</strong> ICC/IF, IHC, IHC-P, WB</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="AF660"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/ctgf-ccn2-antibody_af660" style="overflow: hidden; width: 280px;" title="CTGF/CCN2 Antibody [Unconjugated] - C-terminus">CTGF/CCN2 Antibody<br> [Unconjugated] - C-te ...</a>    </div><div class="sub-header">AF660</div> <div class="images_customers"><div id="ss_prev_cav5" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-5" data-cycle-prev="#ss_prev_cav5" data-cycle-next="#ss_next_cav5" data-cycle-slides="div.big_thumb_cust_container" data-index=5 ><div class="big_thumb_cust_container"> <a href="/products/ctgf-ccn2-antibody_af660" title="CTGF/CCN2 was detected in immersion fixed paraffin-embedded sections of human kidney array using Goat Anti-Human CTGF/CCN2 C-Terminus Antigen Affinity-purified Polyclonal Antibody (Catalog # AF660) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell &amp; Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections." class="cust_viewed_5" > <img loading="lazy" src="https://images.novusbio.com/images2/CTGF_AF660_Immunohistochemistry_9968.jpg" alt="Immunohistochemistry CTGF/CCN2 Antibody [Unconjugated] - C-terminus" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/ctgf-ccn2-antibody_af660" title="CTGF/CCN2 was detected in immersion fixed paraffin-embedded sections of human pancreas array using Goat Anti-Human CTGF/CCN2 C-Terminus Antigen Affinity-purified Polyclonal Antibody (Catalog # AF660) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell &amp; Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections." class="cust_viewed_5" > <img loading="lazy" src="https://images.novusbio.com/images2/CTGF_AF660_Immunohistochemistry_9969.jpg" alt="Immunohistochemistry CTGF/CCN2 Antibody [Unconjugated] - C-terminus" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/ctgf-ccn2-antibody_af660" title="Effect of KIAA1199 knock-down and over-expression on the expression of PLXNB3, SEMA5A and CTGF in fibroblast-like synoviocyte (FLS) cells. (A). Real-time PCR of KIAA1199, PLXNB3, SEMA5A and CTGF transfected with scrambled siRNA, KIAA1199 siRNA duplex, pcDNA3.2DEST and pcDNA3.2DEST-KIAA1199 for 24 h in FLS cells; beta -actin was used as a loading control. (B). Western blotting of KIAA1199, PLXNB3, SEMA5A and CTGF transfected with scrambled siRNA, KIAA1199 siRNA duplex, pcDNA3.2DEST and pcDNA3.2DEST-KIAA1199 for 48 h in FLS cells; beta -actin was used as a loading control. All experiments were performed at least in triplicates, the data are presented as mean ± SD; *P &lt;0.05, compared with control (*significant differences). Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/26022278), licensed under a CC-BY license. Not internally tested by R&amp;D Systems." class="cust_viewed_5" > <img loading="lazy" src="https://images.novusbio.com/images/af660_human-ctgf-ccn2-c-terminus-affinity-purified-polyclonal-ab-822024951141.jpg" alt="Western Blot CTGF/CCN2 Antibody [Unconjugated] - C-terminus" class="big_thumb" /> </a> </div></div><div id="ss_next_cav5" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-5" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/ctgf-ccn2-antibody_af660#PublicationSection"> <div class="sprite_pubBook"></div> (7 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> IHC</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="DVE00"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/human-vegf-quantikine-elisa-kit_dve00" style="overflow: hidden; width: 280px;" title="VEGF [HRP]">VEGF [HRP]</a>    </div><div class="sub-header">DVE00</div> <div class="images_customers"><div id="ss_prev_cav6" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-6" data-cycle-prev="#ss_prev_cav6" data-cycle-next="#ss_next_cav6" data-cycle-slides="div.big_thumb_cust_container" data-index=6 ><div class="big_thumb_cust_container"> <a href="/products/human-vegf-quantikine-elisa-kit_dve00" title="" class="cust_viewed_6" > <img loading="lazy" src="https://images.novusbio.com/images2/DATA_VEGF_DVE00_ELISA_871.jpg" alt="N/A VEGF [HRP]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/human-vegf-quantikine-elisa-kit_dve00" title="" class="cust_viewed_6" > <img loading="lazy" src="https://images.novusbio.com/images2/DATA_VEGF_DVE00_ELISA_872.jpg" alt="N/A VEGF [HRP]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/human-vegf-quantikine-elisa-kit_dve00" title="" class="cust_viewed_6" > <img loading="lazy" src="https://images.novusbio.com/images2/VEGF_DVE00_ELISA_208.jpg" alt="N/A VEGF [HRP]" class="big_thumb" /> </a> </div></div><div id="ss_next_cav6" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-6" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/human-vegf-quantikine-elisa-kit_dve00#PublicationSection"> <div class="sprite_pubBook"></div> (685 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> ELISA</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="NBP1-91258"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/fibronectin-antibody_nbp1-91258" style="overflow: hidden; width: 280px;" title="Fibronectin Antibody - BSA Free">Fibronectin<br> Antibody - BSA Free</a>    </div><div class="sub-header">NBP1-91258</div> <div class="images_customers"><div id="ss_prev_cav7" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-7" data-cycle-prev="#ss_prev_cav7" data-cycle-next="#ss_next_cav7" data-cycle-slides="div.big_thumb_cust_container" data-index=7 ><div class="big_thumb_cust_container"> <a href="/products/fibronectin-antibody_nbp1-91258" title="Western Blot: Fibronectin Antibody - BSA Free [NBP1-91258] - Nicotinamide (NAM) attenuates unilateral urethral obstruction (UUO)-induced renal interstitial fibrosis. C57BL/6 mice were subjected to UUO surgery or sham operation. Different doses of NAM or saline were intraperitoneally injected an hour before the surgery and daily thereafter. Representative images of Western blot of FN (fibronectin), alpha-SMA (alpha-smooth muscle actin) and GAPDH (loading control). Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/30993884/) licensed under a CC-BY license." class="cust_viewed_7" > <img loading="lazy" src="https://images.novusbio.com/images/Fibronectin Antibody - BSA Free-Western Blot-NBP1-91258-img0022.jpg" alt="Western Blot Fibronectin Antibody - BSA Free" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/fibronectin-antibody_nbp1-91258" title="Western Blot: Fibronectin Antibody - BSA Free [NBP1-91258] - Analysis of Fibronectin in HepG2 cell lysate." class="cust_viewed_7" > <img loading="lazy" src="https://images.novusbio.com/images/Fibronectin-Antibody---BSA-Free-Western-Blot-NBP1-91258-img0003.jpg" alt="Western Blot Fibronectin Antibody - BSA Free" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/fibronectin-antibody_nbp1-91258" title="Western Blot: Fibronectin Antibody - BSA Free [NBP1-91258] - Analysis of Fibronectin in NIH 3T3 cell lysate." class="cust_viewed_7" > <img loading="lazy" src="https://images.novusbio.com/images/Fibronectin-Antibody---BSA-Free-Western-Blot-NBP1-91258-img0004.jpg" alt="Western Blot Fibronectin Antibody - BSA Free" class="big_thumb" /> </a> </div></div><div id="ss_next_cav7" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-7" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/fibronectin-antibody_nbp1-91258#ReviewsSection"> <div class="sprite_4Stars"></div> (11 Reviews</a>) </div> <div class="tiny"> <a href="/products/fibronectin-antibody_nbp1-91258#PublicationSection"> <div class="sprite_pubBook"></div> (56 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Bv, Ca, Eq, Fe, Hu, Mu, Po, Rt</div><div class="tiny"><strong>Applications:</strong> ICC/IF, IHC, IHC-Fr, IHC-P, Simple Western, WB</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="233-FB"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/recombinant-human-fgf-basic-fgf2-bfgf-146-aa-protein_233-fb" style="overflow: hidden; width: 280px;" title="FGF basic/FGF2/bFGF [Unconjugated]">FGF<br> basic/FGF2/bFGF [Unco</a>    </div><div class="sub-header">233-FB</div> <div class="images_customers"><div class="one_image_l"></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-8" data-cycle-prev="#ss_prev_cav8" data-cycle-next="#ss_next_cav8" data-cycle-slides="div.big_thumb_cust_container" data-index=8 ><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-fgf-basic-fgf2-bfgf-146-aa-protein_233-fb" title="FGF basic/FGF2/bFGF [Unconjugated]" class="cust_viewed_8"> <img loading="lazy" src="/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png" alt="FGF basic/FGF2/bFGF [Unconjugated]" title="FGF basic/FGF2/bFGF [Unconjugated]" class=" big_thumb" /> </a> </div></div><div class="one_image"></div><div class="one_image_11"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/recombinant-human-fgf-basic-fgf2-bfgf-146-aa-protein_233-fb#PublicationSection"> <div class="sprite_pubBook"></div> (559 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> BA</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="NBP1-82847"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/lap3-antibody_nbp1-82847" style="overflow: hidden; width: 280px;" title="LAP3 Antibody">LAP3 Antibody</a>    </div><div class="sub-header">NBP1-82847</div> <div class="images_customers"><div id="ss_prev_cav9" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-9" data-cycle-prev="#ss_prev_cav9" data-cycle-next="#ss_next_cav9" data-cycle-slides="div.big_thumb_cust_container" data-index=9 ><div class="big_thumb_cust_container"> <a href="/products/lap3-antibody_nbp1-82847" title="Immunohistochemistry-Paraffin: LAP3 Antibody [NBP1-82847] - Staining of human lymph node shows high expression." class="cust_viewed_9" > <img loading="lazy" src="https://images.novusbio.com/images/LAP3-Antibody-Immunohistochemistry-Paraffin-NBP1-82847-img0008.jpg" alt="Immunohistochemistry-Paraffin LAP3 Antibody" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/lap3-antibody_nbp1-82847" title="Immunohistochemistry-Paraffin: LAP3 Antibody [NBP1-82847] - Staining of human skeletal muscle shows low expression as expected." class="cust_viewed_9" > <img loading="lazy" src="https://images.novusbio.com/images/LAP3-Antibody-Immunohistochemistry-Paraffin-NBP1-82847-img0009.jpg" alt="Immunohistochemistry-Paraffin LAP3 Antibody" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/lap3-antibody_nbp1-82847" title="Immunohistochemistry-Paraffin: LAP3 Antibody [NBP1-82847] - Staining in human lymph node and skeletal muscle tissues using anti-LAP3 antibody. Corresponding LAP3 RNA-seq data are presented for the same tissues." class="cust_viewed_9" > <img loading="lazy" src="https://images.novusbio.com/images/LAP3-Antibody-Immunohistochemistry-Paraffin-NBP1-82847-img0010.jpg" alt="Immunohistochemistry-Paraffin LAP3 Antibody" class="big_thumb" /> </a> </div></div><div id="ss_next_cav9" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-9" class="cycle-circle-pager"></div></div> <div class="ds_info"><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> ICC/IF, IHC, IHC-P, WB</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="AF3025"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/tgf-beta-ri-alk-5-antibody_af3025" style="overflow: hidden; width: 280px;" title="TGF-beta RI/ALK-5 Antibody [Unconjugated]">TGF-beta RI/ALK-5<br> Antibody [Unconjugate ...</a>    </div><div class="sub-header">AF3025</div> <div class="images_customers"><div id="ss_prev_cav10" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-10" data-cycle-prev="#ss_prev_cav10" data-cycle-next="#ss_next_cav10" data-cycle-slides="div.big_thumb_cust_container" data-index=10 ><div class="big_thumb_cust_container"> <a href="/products/tgf-beta-ri-alk-5-antibody_af3025" title="Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, HepG2 human hepatocellular carcinoma cell line, and Raji human Burkitt's lymphoma cell line. PVDF membrane was probed with 0.2 µg/mL of Goat Anti-Human TGF-beta RI/ALK-5 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3025) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). Specific bands were detected for TGF-beta RI/ALK-5 at approximately 50 &amp; 56 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="cust_viewed_10" > <img loading="lazy" src="https://images.novusbio.com/images2/TGFbeta_RI_AF3025_Western_Blot_17081.jpg" alt="Western Blot TGF-beta RI/ALK-5 Antibody [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/tgf-beta-ri-alk-5-antibody_af3025" title="TGF-beta RI/ALK-5 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) stimulated with LPS and monensin using Goat Anti-Human TGF-beta RI/ALK-5 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3025) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights&amp;#8482; 557-conjugated Anti-Goat IgG Secondary Antibody (yellow; Catalog # NL001) and counter-stained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Non-adherent Cells." class="cust_viewed_10" > <img loading="lazy" src="https://images.novusbio.com/images2/TGF-beta_RI_AF3025_Immunocytochemistry_9948.jpg" alt="Immunocytochemistry TGF-beta RI/ALK-5 Antibody [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/tgf-beta-ri-alk-5-antibody_af3025" title="Myostatin signaling in longissimus dorsi muscle of low-birth-weight (LBWT) and normal-birth-weight (NBWT) neonatal pigs. (A): Representative western blots from four pairs of LBWT and NBWT pigs (N, NBWT; L, LBWT). (B–G): Protein abundance of myostain, ALK5 and ActRIIB, and protein abundance phosphorylation of smad2/3. Abundance was normalized to alpha -tubulin and phosphorylation normalized to the corresponding non-phospho-proteins. Results are means ± SE. n = 12. Values with different letters differ significantly (P ≤ 0.05). Image collected and cropped by CiteAb from the following publication (https://journal.frontiersin.org/article/10.3389/fphys.2017.00482/full), licensed under a CC-BY license. Not internally tested by R&amp;D Systems." class="cust_viewed_10" > <img loading="lazy" src="https://images.novusbio.com/images/af3025_human-tgf-beta-ri-alk-5-affinity-purified-polyclonal-ab-41202412402510.jpg" alt="Western Blot TGF-beta RI/ALK-5 Antibody [Unconjugated]" class="big_thumb" /> </a> </div></div><div id="ss_next_cav10" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-10" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/tgf-beta-ri-alk-5-antibody_af3025#PublicationSection"> <div class="sprite_pubBook"></div> (16 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> ELISA, ICC, WB</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="236-EG"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/recombinant-human-egf-protein-cf_236-eg" style="overflow: hidden; width: 280px;" title="EGF [Unconjugated]">EGF [Unconjugated]</a>    </div><div class="sub-header">236-EG</div> <div class="images_customers"><div id="ss_prev_cav11" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-11" data-cycle-prev="#ss_prev_cav11" data-cycle-next="#ss_next_cav11" data-cycle-slides="div.big_thumb_cust_container" data-index=11 ><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-egf-protein-cf_236-eg" title="1 µg/lane of Recombinant Human EGF was resolved with SDS-PAGE and visualized by silver staining under reducing (R) conditions, showing a single band at 6 kDa." class="cust_viewed_11" > <img loading="lazy" src="https://images.novusbio.com/images2/EGF_236-EG_234.jpg" alt="SDS-PAGE EGF [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-egf-protein-cf_236-eg" title="Recombinant Human EGF (Catalog # 236‑EG) stimulates cell proliferation of the Balb/3T3 mouse embryonic fibroblast cell line. The ED50 for this effect is 20‑100 pg/mL." class="cust_viewed_11" > <img loading="lazy" src="https://images.novusbio.com/images2/EGF_236EG_1570.jpg" alt="Bioactivity EGF [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-egf-protein-cf_236-eg" title="iPSC-derived human intestinal organoids were cultured using Cultrex&amp;#8482; UltiMatrix RGF Basement Membrane Extract (BME001-05) and intestinal organoid culture medium, which includes Recombinant Human EGF (Catalog # 236-EG), Recombinant Human Noggin (6057-NG), Recombinant Human R-Spondin 1 (4645-RS), and Recombinant Human Wnt-3a (5036-WN), along with the other reagents listed in the intestinal organoid culture medium recipe in the human intestinal organoid culture protocol. (A) Human intestinal organoids were stained using a Rat Anti-Human/Mouse/Rat Vimentin Monoclonal Antibody (MAB2105; green) and a Goat Anti-Human/Mouse Desmin Antigen Affinity-purified Polyclonal Antibody (AF3844; red) to visualize myofibroblast cells and counterstained with DAPI (5748; blue). (B) Human intestinal organoids were stained using a Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (AF748; green) and a Mouse Anti-Human MUC2 Monoclonal Antibody (Novus Biologicals, Catalog # NBP2-44431; red) and counterstained with DAPI (5748; blue)." class="cust_viewed_11" > <img loading="lazy" src="https://images.novusbio.com/images/236-eg_recombinant-human-egf-protein-cf-bioactivity-25202394053.jpg" alt="Cell Culture EGF [Unconjugated]" class="big_thumb" /> </a> </div></div><div id="ss_next_cav11" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-11" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/recombinant-human-egf-protein-cf_236-eg#PublicationSection"> <div class="sprite_pubBook"></div> (861 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> BA</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="AF2097"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/smad4-antibody_af2097" style="overflow: hidden; width: 280px;" title="Smad4 Antibody [Unconjugated]">Smad4 Antibody<br> [Unconjugated]</a>    </div><div class="sub-header">AF2097</div> <div class="images_customers"><div id="ss_prev_cav12" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-12" data-cycle-prev="#ss_prev_cav12" data-cycle-next="#ss_next_cav12" data-cycle-slides="div.big_thumb_cust_container" data-index=12 ><div class="big_thumb_cust_container"> <a href="/products/smad4-antibody_af2097" title="Jurkat human acute T cell leukemia cell line treated with 10&amp;nbsp;ng/mL Recombinant Human IL‑12 (Catalog&amp;nbsp;# 219-IL) overnight was fixed using formaldehyde, resuspended in lysis buffer, and sonicated to shear chromatin. Smad4/DNA complexes were immunoprecipitated using 5&amp;nbsp;μg Goat Anti-Human Smad4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2097) or control antibody (Catalog&amp;nbsp;# AB‑108‑C) for 15&amp;nbsp;minutes in an ultrasonic bath, followed by Biotinylated Anti-Goat IgG Secondary Antibody (Catalog&amp;nbsp;# BAF109). Immunocomplexes were captured using 50&amp;nbsp;μL of MagCellect Streptavidin Ferrofluid (Catalog&amp;nbsp;# MAG999) and DNA was purified using chelating resin solution. The p21 promoter was detected by standard PCR." class="cust_viewed_12" > <img loading="lazy" src="https://images.novusbio.com/images2/Smad4_AF2097_Chromatin_Immunoprecipitation_11225.jpg" alt="Chromatin Immunoprecipitation (ChIP) Smad4 Antibody [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/smad4-antibody_af2097" title="Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, Jurkat human acute T cell leukemia cell line, and K562 human chronic myelogenous leukemia cell line. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Human Smad4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2097) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for Smad4 at approximately 60 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="cust_viewed_12" > <img loading="lazy" src="https://images.novusbio.com/images2/Smad4_AF2097_Western_Blot_17168.jpg" alt="Western Blot Smad4 Antibody [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/smad4-antibody_af2097" title="Smad4 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) using Goat Anti-Human Smad4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2097) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights&amp;#8482; 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells." class="cust_viewed_12" > <img loading="lazy" src="https://images.novusbio.com/images2/Smad4_AF2097_Immunocytochemistry__Immunofluorescence_17807.jpg" alt="Immunocytochemistry Smad4 Antibody [Unconjugated]" class="big_thumb" /> </a> </div></div><div id="ss_next_cav12" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-12" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/smad4-antibody_af2097#PublicationSection"> <div class="sprite_pubBook"></div> (9 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> ChIP, ICC, WB</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="7754-BH/CF"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/recombinant-human-tgf-beta-1-human-cell-expressed-cf_7754-bh-cf" style="overflow: hidden; width: 280px;" title="TGF-beta 1 [Unconjugated]">TGF-beta 1<br> [Unconjugated]</a>    </div><div class="sub-header">7754-BH/CF</div> <div class="images_customers"><div class="one_image_l"></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-13" data-cycle-prev="#ss_prev_cav13" data-cycle-next="#ss_next_cav13" data-cycle-slides="div.big_thumb_cust_container" data-index=13 ><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-tgf-beta-1-human-cell-expressed-cf_7754-bh-cf" title="Recombinant human TGF-beta 1 (7754-BH/CF) inhibits recombinant mouse IL-4 induced proliferation in the HT-2 mouse T cell line. The ED50 for this effect is 0.04-0.2 ng/mL." class="cust_viewed_13" > <img loading="lazy" src="https://images.novusbio.com/images/protein/7754-bhcf_recombinant-human-tgf-beta-1-human-cell-expressed-cf-bioactivity-1811202013946.jpg" alt="Bioactivity TGF-beta 1 [Unconjugated]" class="big_thumb" /> </a> </div></div><div class="one_image"></div><div class="one_image_11"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/recombinant-human-tgf-beta-1-human-cell-expressed-cf_7754-bh-cf#PublicationSection"> <div class="sprite_pubBook"></div> (53 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> BA</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="AF1230"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/erk2-antibody_af1230" style="overflow: hidden; width: 280px;" title="ERK2 Antibody [Unconjugated]">ERK2 Antibody<br> [Unconjugated]</a>    </div><div class="sub-header">AF1230</div> <div class="images_customers"><div id="ss_prev_cav14" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-14" data-cycle-prev="#ss_prev_cav14" data-cycle-next="#ss_next_cav14" data-cycle-slides="div.big_thumb_cust_container" data-index=14 ><div class="big_thumb_cust_container"> <a href="/products/erk2-antibody_af1230" title="Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, MCF-7 human breast cancer cell line, U937 human histiocytic lymphoma cell line, PC-12 rat adrenal pheochromocytoma cell line, and NIH-3T3 mouse embryonic fibroblast cell line. PVDF membrane was probed with 0.1 µg/mL of Rabbit Anti-Human/Mouse/Rat ERK2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1230) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008). A specific band was detected for ERK2 at approximately 42 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="cust_viewed_14" > <img loading="lazy" src="https://images.novusbio.com/images2/ERK2_AF1230_Western_Blot_5097.jpg" alt="Western Blot ERK2 Antibody [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/erk2-antibody_af1230" title=" ERK2 was detected in immersion fixed paraffin-embedded sections of human breast using Rabbit Anti-Human/Mouse/Rat ERK2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1230) at 3&amp;nbsp;µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte&amp;#8482; HRP Polymer Antibody (Catalog&amp;nbsp;# VC003). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in epithelial cells. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents. " class="cust_viewed_14" > <img loading="lazy" src="https://images.novusbio.com/images2/ERK2_AF1230_Immunohistochemistry_20696.jpg" alt="Immunohistochemistry ERK2 Antibody [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/erk2-antibody_af1230" title="Western blot shows lysates of HeLa human cervical epithelial carcinoma parental cell line and ERK2 knockout HeLa cell line (KO). PVDF membrane was probed with 0.1 µg/mL of Rabbit Anti-Human/Mouse/Rat ERK2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1230) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008). A specific band was detected for ERK2 at approximately 42 kDa (as indicated) in the parental HeLa cell line, but is not detectable in knockout HeLa cell line. GAPDH (Catalog # AF5718) is shown as a loading control. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="cust_viewed_14" > <img loading="lazy" src="https://images.novusbio.com/images2/ERK2_AF1230_Knockout_Validated_22864.jpg" alt="Knockout Validated ERK2 Antibody [Unconjugated]" class="big_thumb" /> </a> </div></div><div id="ss_next_cav14" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-14" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/erk2-antibody_af1230#PublicationSection"> <div class="sprite_pubBook"></div> (3 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu, Mu, Rt</div><div class="tiny"><strong>Applications:</strong> IHC, KO, WB</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="6507-IL/CF"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/recombinant-human-il-4-cho-expressed-protein-cf_6507-il-cf" style="overflow: hidden; width: 280px;" title="IL-4 [Unconjugated]">IL-4 [Unconjugated]</a>    </div><div class="sub-header">6507-IL/CF</div> <div class="images_customers"><div class="one_image_l"></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-15" data-cycle-prev="#ss_prev_cav15" data-cycle-next="#ss_next_cav15" data-cycle-slides="div.big_thumb_cust_container" data-index=15 ><div class="big_thumb_cust_container"> <a href="/products/recombinant-human-il-4-cho-expressed-protein-cf_6507-il-cf" title="Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is 0.05-0.2 ng/mL." class="cust_viewed_15" > <img loading="lazy" src="https://images.novusbio.com/images/protein/6507-ilcf_recombinant-human-il-4-cho-expressed-protein-cf-bioactivity-272020133214.jpg" alt="Bioactivity IL-4 [Unconjugated]" class="big_thumb" /> </a> </div></div><div class="one_image"></div><div class="one_image_11"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/recombinant-human-il-4-cho-expressed-protein-cf_6507-il-cf#PublicationSection"> <div class="sprite_pubBook"></div> (3 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu</div><div class="tiny"><strong>Applications:</strong> BA</div> </div> </div> </div></div><div class="ds_cav_group"> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="MAB2029"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/smad7-antibody-293039_mab2029" style="overflow: hidden; width: 280px;" title="Smad7 Antibody (293039) [Unconjugated]">Smad7 Antibody<br> (293039) [Unconjugate</a>    </div><div class="sub-header">MAB2029</div> <div class="images_customers"><div id="ss_prev_cav16" class="cycle-pager"> <div class="pager_left_on"></div></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-16" data-cycle-prev="#ss_prev_cav16" data-cycle-next="#ss_next_cav16" data-cycle-slides="div.big_thumb_cust_container" data-index=16 ><div class="big_thumb_cust_container"> <a href="/products/smad7-antibody-293039_mab2029" title="Western blot shows lysates of H9 human cutaneous T lymphoma cell line, PT18 mouse mast/basophil cell line, and Rat-2 rat embryonic fibroblast cell line. PVDF membrane was probed with 1 µg/mL of Human/Mouse/Rat Smad7 Monoclonal Antibody (Catalog # MAB2029) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for Smad7 at approximately 50 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2." class="cust_viewed_16" > <img loading="lazy" src="https://images.novusbio.com/images2/Smad7_MAB2029_Western_Blot_6004.jpg" alt="Western Blot Smad7 Antibody (293039) [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/smad7-antibody-293039_mab2029" title="Smad7 was detected in immersion fixed paraffin-embedded sections of human liver cancer tissue using 25 &amp;micro;g/mL Human/Mouse/Rat Smad7 Monoclonal Antibody (Catalog # MAB2029) overnight at 4 &amp;deg;C. Tissue was stained with the Anti-Mouse HRP-DAB Cell &amp; Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections." class="cust_viewed_16" > <img loading="lazy" src="https://images.novusbio.com/images2/Smad7_MAB2029_Immunohistochemistry_6962.jpg" alt="Immunohistochemistry Smad7 Antibody (293039) [Unconjugated]" class="big_thumb" /> </a> </div><div class="big_thumb_cust_container"> <a href="/products/smad7-antibody-293039_mab2029" title="Smad7 was detected in immersion fixed paraffin-embedded sections of human liver array using Human/Mouse/Rat Smad7 Monoclonal Antibody (Catalog # MAB2029) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell &amp; Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections." class="cust_viewed_16" > <img loading="lazy" src="https://images.novusbio.com/images2/Smad7_MAB2029_Immunohistochemistry_9846.jpg" alt="Immunohistochemistry Smad7 Antibody (293039) [Unconjugated]" class="big_thumb" /> </a> </div></div><div id="ss_next_cav16" class="cycle-pager"><div class="pager_right_on"></div></div><div id="cycle-circle-pager-16" class="cycle-circle-pager"></div></div> <div class="ds_info"> <div class="tiny"> <a href="/products/smad7-antibody-293039_mab2029#ReviewsSection"> <div class="sprite_3Stars"></div> (1 Review</a>) </div> <div class="tiny"> <a href="/products/smad7-antibody-293039_mab2029#PublicationSection"> <div class="sprite_pubBook"></div> (59 Publications</a>) </div><div class="tiny"><strong>Species:</strong> Hu, Mu, Rt</div><div class="tiny"><strong>Applications:</strong> IHC, Simple Western, WB</div> </div> </div> </div> <div class="ds_cav_block"> <div class="ds_cav_upper" data-catnums="MAB1835"> <div class="name"> <div class="flourish_left"></div> <div class="flourish_right"></div> <a href="/products/tgf-beta-1-2-3-antibody-1d11_mab1835" style="overflow: hidden; width: 280px;" title="TGF beta 1/2/3 Antibody (1D11) [Unconjugated]">TGF beta 1/2/3<br> Antibody (1D11) [Unco ...</a>    </div><div class="sub-header">MAB1835</div> <div class="images_customers"><div class="one_image_l"></div><div class="cycle-slideshow" data-cycle-fx="fade" data-cycle-timeout="0" data-cycle-pager="#cycle-circle-pager-17" data-cycle-prev="#ss_prev_cav17" data-cycle-next="#ss_next_cav17" data-cycle-slides="div.big_thumb_cust_container" data-index=17 ><div class="big_thumb_cust_container"> <a href="/products/tgf-beta-1-2-3-antibody-1d11_mab1835" title="TGF beta 1/2/3 Antibody (1D11) [Unconjugated]" class="cust_viewed_17"> <img loading="lazy" src="/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png" alt="TGF beta 1/2/3 Antibody (1D11) [Unconjugated]" title="TGF beta 1/2/3 Antibody (1D11) [Unconjugated]" class=" big_thumb" /> </a> </div></div><div class="one_image"></div><div class="one_image_11"></div></div> <div class="ds_info"><div class="tiny"><strong>Species:</strong> All-Multi</div><div class="tiny"><strong>Applications:</strong> WB, B/N, ELISA(Cap)</div> </div> </div> </div></div> </div><div id="cav_next"><div class="sprite_rightArrow"></div></div> <div class="clear"></div></div> <div class="ds_tab_content equalbottom" id="content_reviews-publications"> <a id="reviews-publications"></a><a id="PublicationSection"></a><h2 class="greyHead2">Publications for TGF beta 1/2/3 Antibody (MAB1835)(226)</h2><div class="ds_info"> <div>We have publications tested in 13 confirmed species: Human, Mouse, Rat, Bovine, Canine, Chicken, Hamster, Mink, Opossum, Porcine, Primate - Macaca mulatta (Rhesus Macaque), Rabbit, Transgenic Mouse.<br /><br />We have publications tested in 20 applications: Activation, Agonist Activity, Bioassay, Blocking, Co-IP, Dot Blot, ELISA Capture, ELISA Development, ELISA Development (Capture), Flow Cytometry, Functional Assay, ICC, IHC, IHC-Fr, IHC-P, Immunodepletion, In Vivo, Luminex Development, Neutralization, Western Blot.<br /><br /><div class="align-right"> <button class="greybutton btn_width" name="novusreview" onclick="window.location='/publications'"; >Submit a Publication</button><br /> </div> </div><div> <div class="filterParent"> <div class="publications_filterList" id="pubapp"> <div class="blueHead">Filter By Application</div><div class="filter_line"> <input type="checkbox" value="application" class="publication_filterCheckbox" data-filter="Activation"> <div style="display:inline;">Activation</div> (1)</div><div class="filter_line"> <input type="checkbox" value="application" class="publication_filterCheckbox" data-filter="Agonist Activity"> <div style="display:inline;">Agonist Activity</div> (1)</div><div class="filter_line"> <input type="checkbox" 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data-filter="species">All Species</div></div> </div></div> <div class="clear"></div> <div id="publications_list">Showing Publications 1 - <span id="appcnt">10</span> of 226. <a class="pubs_showall">Show All 226 Publications.</a> <a class="pubs_collapse" style="display:none;">Collapse Publications.</a><table class="wide lightPad tablesorter" id="publications_list_table"> <thead> <tr> <th>Publications using MAB1835</th> <th>Applications</th> <th>Species</th> </tr> </thead> <tbody><tr class="lined revfil firstten" data-application="Neutralization" data-species="Transgenic Mouse"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/39325665" target="_blank" rel="nofollow"> Chen, Y;Chen, M;Liu, Y;Li, Q;Xue, Y;Liu, L;Liang, R;Xiong, Y;Zhao, J;Chen, J;Lin, W;Wang, J;Pan, YF;Stohl, W;Zheng, SG; BAFF promotes follicular helper T cell development and germinal center formation through BR3 signal JCI insight 2024-11-08 [PMID: 39325665] (Neutralization, Transgenic Mouse) </a></td> <td valign="top">Neutralization</td> <td valign="top">Transgenic Mouse</td> </tr><tr class="lined revfil firstten" data-application="Neutralization" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/38729997" target="_blank" rel="nofollow"> Jeong, H;Koh, J;Kim, S;Song, SG;Lee, SH;Jeon, Y;Lee, CH;Keam, B;Lee, SH;Chung, DH;Jeon, YK; Epithelial-mesenchymal transition induced by tumor cell-intrinsic PD-L1 signaling predicts a poor response to immune checkpoint inhibitors in PD-L1-high lung cancer British journal of cancer 2024-05-10 [PMID: 38729997] (Neutralization, Human) </a></td> <td valign="top">Neutralization</td> <td valign="top">Human</td> </tr><tr class="lined revfil firstten" data-application="Flow Cytometry" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/38612935" target="_blank" rel="nofollow"> Seller, A;Tegeler, CM;Mauermann, J;Schreiber, T;Hagelstein, I;Liebel, K;Koch, A;Heitmann, JS;Greiner, SM;Hayn, C;Dannehl, D;Engler, T;Hartkopf, AD;Hahn, M;Brucker, SY;Salih, HR;Märklin, M; Soluble NKG2DLs Are Elevated in Breast Cancer Patients and Associate with Disease Outcome International journal of molecular sciences 2024-04-08 [PMID: 38612935] (Flow Cytometry, Human) </a></td> <td valign="top">Flow Cytometry</td> <td valign="top">Human</td> </tr><tr class="lined revfil firstten" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/38467661" target="_blank" rel="nofollow"> Kostadinova, R;Ströbel, S;Chen, L;Fiaschetti-Egli, K;Gadient, J;Pawlowska, A;Petitjean, L;Bieri, M;Thoma, E;Petitjean, M; Digital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model Scientific reports 2024-03-11 [PMID: 38467661] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil firstten" data-application="Neutralization" data-species=""> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/37460534" target="_blank" rel="nofollow"> Petillo, S;Sproviero, E;Loconte, L;Cuollo, L;Zingoni, A;Molfetta, R;Fionda, C;Soriani, A;Cerboni, C;Petrucci, MT;Fazio, F;Paolini, R;Santoni, A;Cippitelli, M; NEDD8-activating enzyme inhibition potentiates the anti-myeloma activity of natural killer cells Cell death & disease 2023-07-17 [PMID: 37460534] (Neutralization) </a></td> <td valign="top">Neutralization</td> <td valign="top"></td> </tr><tr class="lined revfil firstten" data-application="Neutralization" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/37345186" target="_blank" rel="nofollow"> Michielon, E;López González, M;Stolk, DA;Stolwijk, JGC;Roffel, S;Waaijman, T;Lougheed, SM;de Gruijl, TD;Gibbs, S; A Reconstructed Human Melanoma-in-Skin Model to Study Immune Modulatory and Angiogenic Mechanisms Facilitating Initial Melanoma Growth and Invasion Cancers 2023-05-20 [PMID: 37345186] (Neutralization, Human) </a></td> <td valign="top">Neutralization</td> <td valign="top">Human</td> </tr><tr class="lined revfil firstten" data-application="Neutralization" data-species="Mouse"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/37240029" target="_blank" rel="nofollow"> Marvin, DL;Dijkstra, J;Zulfiqar, RM;Vermeulen, M;Ten Dijke, P;Ritsma, L; TGF-? Type I Receptor Signaling in Melanoma Liver Metastases Increases Metastatic Outgrowth International journal of molecular sciences 2023-05-12 [PMID: 37240029] (Neutralization, Mouse) </a></td> <td valign="top">Neutralization</td> <td valign="top">Mouse</td> </tr><tr class="lined revfil firstten" data-application="Bioassay" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/37226092" target="_blank" rel="nofollow"> Carneiro, CS;Hapeman, JD;Nedelcu, AM; Synergistic inter-clonal cooperation involving crosstalk, co-option and co-dependency can enhance the invasiveness of genetically distant cancer clones BMC ecology and evolution 2023-05-24 [PMID: 37226092] (Bioassay, Human) </a></td> <td valign="top">Bioassay</td> <td valign="top">Human</td> </tr><tr class="lined revfil firstten" data-application="Neutralization" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/36640334" target="_blank" rel="nofollow"> S Vondra, AL Höbler, AI Lackner, J Raffetsede, ZN Mihalic, A Vogel, L Saleh, V Kunihs, P Haslinger, M Wahrmann, H Husslein, R Oberle, J Kargl, S Haider, P Latos, G Schabbauer, M Knöfler, J Ernerudh, J Pollheimer The human placenta shapes the phenotype of decidual macrophages Cell Reports, 2023-01-10;42(1):111977. 2023-01-10 [PMID: 36640334] (Neutralization, Human) </a></td> <td valign="top">Neutralization</td> <td valign="top">Human</td> </tr><tr class="lined revfil firstten" data-application="" data-species=""> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/36466890" target="_blank" rel="nofollow"> Cinzia Fionda, Silvia Ruggeri, Giuseppe Sciumè, Mattia Laffranchi, Isabella Quinti, Cinzia Milito et al. Age-dependent NK cell dysfunctions in severe COVID-19 patients Frontiers in Immunology 11/17/2022 [PMID: 36466890] </a></td> <td valign="top"></td> <td valign="top"></td> </tr><tr class="lined revfil hidden" data-application="ELISA Capture" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/36456734" target="_blank" rel="nofollow"> SI Gringhuis, TM Kaptein, EBM Remmerswaa, A Drewniak, BA Wevers, B Theelen, GRAM D'Haens, T Boekhout, TBH Geijtenbee Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs Nature Immunology, 2022-12-01;0(0):. 2022-12-01 [PMID: 36456734] (ELISA Capture, Human) </a></td> <td valign="top">ELISA Capture</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Neutralization" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/36418470" target="_blank" rel="nofollow"> W Zeng, L Xiong, W Wu, S Li, J Liu, L Yang, L Lao, P Huang, M Zhang, H Chen, N Miao, Z Lin, Z Liu, X Yang, J Wang, P Wang, E Song, Y Yao, Y Nie, J Chen, D Huang CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype Oncogene, 2022-11-22;0(0):. 2022-11-22 [PMID: 36418470] (Neutralization, Human) </a></td> <td valign="top">Neutralization</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="ICC" data-species="Mouse"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/36411280" target="_blank" rel="nofollow"> A Nawaz, M Bilal, S Fujisaka, T Kado, MR Aslam, S Ahmed, K Okabe, Y Igarashi, Y Watanabe, T Kuwano, K Tsuneyama, A Nishimura, Y Nishida, S Yamamoto, M Sasahara, J Imura, H Mori, MM Matzuk, F Kudo, I Manabe, A Uezumi, T Nakagawa, Y Oishi, K Tobe Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration Nature Communications, 2022-11-21;13(1):7058. 2022-11-21 [PMID: 36411280] (ICC, Mouse) </a></td> <td valign="top">ICC</td> <td valign="top">Mouse</td> </tr><tr class="lined revfil hidden" data-application="Neutralization" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/36343916" target="_blank" rel="nofollow"> LAG Maldonado, CR Nascimento, NAR Fernandes, ALP Silva, NJ D'Silva, C Rossa Influence of tumor cell-derived TGF-beta on macrophage phenotype and macrophage-mediated tumor cell invasion The international journal of biochemistry & cell biology, 2022-11-04;153(0):106330. 2022-11-04 [PMID: 36343916] (Neutralization, Human) </a></td> <td valign="top">Neutralization</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="" data-species=""> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/36189081" target="_blank" rel="nofollow"> Masaki Takahashi, Yoshifumi Hashimoto, Yoshikazu Nakamura Anti-TGF-beta 1 aptamer enhances therapeutic effect of tyrosine kinase inhibitor, gefitinib, on non-small cell lung cancer in xenograft model Molecular Therapy - Nucleic Acids 2022-09-13 [PMID: 36189081] </a></td> <td valign="top"></td> <td valign="top"></td> </tr><tr class="lined revfil hidden" data-application="Neutralization" data-species="Mouse"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/36182776" target="_blank" rel="nofollow"> Z Shen, W Luo, B Tan, K Nie, M Deng, S Wu, M Xiao, X Wu, X Meng, T Tong, C Zhang, K Ma, Y Liao, J Xu, X Wang Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn&#039;s disease EBioMedicine, 2022-09-28;85(0):104285. 2022-09-28 [PMID: 36182776] (Neutralization, Mouse) </a></td> <td valign="top">Neutralization</td> <td valign="top">Mouse</td> </tr><tr class="lined revfil hidden" data-application="IHC" data-species="Mouse"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/36018840" target="_blank" rel="nofollow"> T Otsuki, N Fukuda, L Chen, A Tsunemi, M Abe Twist-related protein 1 induces epithelial-mesenchymal transition and renal fibrosis through the upregulation of complement 3 PLoS ONE, 2022-08-26;17(8):e0272917. 2022-08-26 [PMID: 36018840] (IHC, Mouse) </a></td> <td valign="top">IHC</td> <td valign="top">Mouse</td> </tr><tr class="lined revfil hidden" data-application="Neutralization" data-species="Mouse"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/35835905" target="_blank" rel="nofollow"> J Hanna, F Beke, LM O'Brien, C Kapeni, HC Chen, V Carbonaro, AB Kim, K Kishore, TE Adolph, MO Skjoedt, K Skjoedt, M de la Roch, M de la Roch Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity Nature Communications, 2022-07-14;13(1):4075. 2022-07-14 [PMID: 35835905] (Neutralization, Mouse) </a></td> <td valign="top">Neutralization</td> <td valign="top">Mouse</td> </tr><tr class="lined revfil hidden" data-application="Neutralization" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/35562586" target="_blank" rel="nofollow"> GN Yin, DK Kim, JI Kang, Y Im, DS Lee, AR Han, J Ock, MJ Choi, MH Kwon, A Limanjaya, SB Jung, J Yang, KW Min, J Yun, Y Koh, JE Park, D Hwang, JK Suh, JK Ryu, HM Kim Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function Experimental & Molecular Medicine, 2022-05-13;0(0):. 2022-05-13 [PMID: 35562586] (Neutralization, Human) </a></td> <td valign="top">Neutralization</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="" data-species=""> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/35426372" target="_blank" rel="nofollow"> Jiatong Liu, Jun Zhang, Xi Lin, Brendan F. Boyce, Hengwei Zhang, Lianping Xing Age-associated callus senescent cells produce TGF-beta 1 that inhibits fracture healing in aged mice Journal of Clinical Investigation 2022-04-15 [PMID: 35426372] </a></td> <td valign="top"></td> <td valign="top"></td> </tr><tr class="lined revfil hidden" data-application="" data-species=""> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/35197550" target="_blank" rel="nofollow"> Decha Pinkaew, Erik Martinez-Hackert, Wei Jia, Matthew D. King, Fei Miao, Nicole R. Enger et al. Fortilin interacts with TGF-beta 1 and prevents TGF-beta receptor activation Communications Biology 2/23/2022 [PMID: 35197550] </a></td> <td valign="top"></td> <td valign="top"></td> </tr><tr class="lined revfil hidden" data-application="" data-species=""> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/35110356" target="_blank" rel="nofollow"> Martina Svenja Lutz, Boris Klimovich, Stefanie Maurer, Jonas S Heitmann, Melanie Märklin, Latifa Zekri et al. Platelets subvert antitumor efficacy of T cell-recruiting bispecific antibodies Journal for ImmunoTherapy of Cancer 2022-02-02 [PMID: 35110356] </a></td> <td valign="top"></td> <td valign="top"></td> </tr><tr class="lined revfil hidden" data-application="" data-species=""> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/35069531" target="_blank" rel="nofollow"> Jia He, Yue Du, Gaopeng Li, Peng Xiao, Xingzheng Sun, Wenjun Song et al. Myeloid Fbxw7 Prevents Pulmonary Fibrosis by Suppressing TGF-beta Production Frontiers in Immunology 2022-01-05 [PMID: 35069531] </a></td> <td valign="top"></td> <td valign="top"></td> </tr><tr class="lined revfil hidden" data-application="" data-species=""> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/34965027" target="_blank" rel="nofollow"> Bartijn C. H. Pieters, Onno J. Arntz, Joyce Aarts, Anouk L. Feitsma, R. J. Joost van Neerven, Peter M. van der Kraan et al. Bovine Milk‐Derived Extracellular Vesicles Inhibit Catabolic and Inflammatory Processes in Cartilage from Osteoarthritis Patients Molecular Nutrition & Food Research 3/1/2022 [PMID: 34965027] </a></td> <td valign="top"></td> <td valign="top"></td> </tr><tr class="lined revfil hidden" data-application="Co-IP, Western Blot" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/34379688" target="_blank" rel="nofollow"> D Basak, Z Jamal, A Ghosh, PK Mondal, P Dey Talukd, S Ghosh, B Ghosh Roy, R Ghosh, A Halder, A Chowdhury, GK Dhali, BK Chattopadh, ML Saha, A Basu, S Roy, C Mukherjee, NK Biswas, U Chatterji, S Datta Reciprocal interplay between asporin and decorin: Implications in gastric cancer prognosis PLoS ONE, 2021-08-11;16(8):e0255915. 2021-08-11 [PMID: 34379688] (Co-IP, Western Blot, Human) </a></td> <td valign="top">Co-IP, Western Blot</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="" data-species=""> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/34369600" target="_blank" rel="nofollow"> Maria E. C. Bruno, Sujata Mukherjee, Arnold J. Stromberg, Hiroshi Saito, Marlene E. Starr Visceral fat‐specific regulation of plasminogen activator inhibitor‐1 in aged septic mice Journal of Cellular Physiology 2022-01-01 [PMID: 34369600] </a></td> <td valign="top"></td> <td valign="top"></td> </tr><tr class="lined revfil hidden" data-application="Neutralization" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/34201301" target="_blank" rel="nofollow"> G Mestrallet, F Auvré, C Schenowitz, ED Carosella, J LeMaoult, MT Martin, N Rouas-Frei, NO Fortunel Human Keratinocytes Inhibit CD4+ T-Cell Proliferation through TGFB1 Secretion and Surface Expression of HLA-G1 and PD-L1 Immune Checkpoints Cells, 2021-06-08;10(6):. 2021-06-08 [PMID: 34201301] (Neutralization, Human) </a></td> <td valign="top">Neutralization</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="" data-species=""> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/34150776" target="_blank" rel="nofollow"> Laura Duffy, John Henderson, Max Brown, Stefan Pryzborski, Nicola Fullard, Lena Summa et al. Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis Frontiers in Cell and Developmental Biology 2021-06-04 [PMID: 34150776] </a></td> <td valign="top"></td> <td valign="top"></td> </tr><tr class="lined revfil hidden" data-application="ELISA Capture" data-species="Bovine"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/34138960" target="_blank" rel="nofollow"> RJ Playford, MJ Weiser, T Marchbank Methods to improve efficacy of orally administered bioactive peptides using bovine colostrum as an exemplar PLoS ONE, 2021-06-17;16(6):e0253422. 2021-06-17 [PMID: 34138960] (ELISA Capture, Bovine) </a></td> <td valign="top">ELISA Capture</td> <td valign="top">Bovine</td> </tr><tr class="lined revfil hidden" data-application="ICC" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/33784497" target="_blank" rel="nofollow"> KV Manian, CA Galloway, S Dalvi, AA Emanuel, JA Mereness, W Black, L Winschel, C Soto, Y Li, Y Song, W DeMaria, A Kumar, I Slukvin, MP Schwartz, WL Murphy, B Anand-Apte, M Chung, DSW Benoit, R Singh 3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration Cell Stem Cell, 2021-03-29;0(0):. 2021-03-29 [PMID: 33784497] (ICC, Human) </a></td> <td valign="top">ICC</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Dot Blot, Western Blot" data-species="Rat"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/33691102" target="_blank" rel="nofollow"> MR Patel, AM Weaver Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-&amp;beta signaling Cell Reports, 2021-03-09;34(10):108829. 2021-03-09 [PMID: 33691102] (Dot Blot, Western Blot, Rat) </a></td> <td valign="top">Dot Blot, Western Blot</td> <td valign="top">Rat</td> </tr><tr class="lined revfil hidden" data-application="Neutralization" data-species="Mouse"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/33654222" target="_blank" rel="nofollow"> QS Liang, JG Xie, C Yu, Z Feng, J Ma, Y Zhang, D Wang, J Lu, R Zhuang, J Yin Splenectomy improves liver fibrosis via tumor necrosis factor superfamily 14 (LIGHT) through the JNK/TGF-&amp;beta1 signaling pathway Experimental & Molecular Medicine, 2021-03-03;0(0):. 2021-03-03 [PMID: 33654222] (Neutralization, Mouse) </a></td> <td valign="top">Neutralization</td> <td valign="top">Mouse</td> </tr><tr class="lined revfil hidden" data-application="" data-species=""> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/33609307" target="_blank" rel="nofollow"> Zhan‐Wen Liang, Xin‐Xin Ge, Meng‐Dan Xu, Hualong Qin, Meng‐Yao Wu, Meng Shen et al. 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J Exp Med, 2003-12-15;198(12):1875-86. 2003-12-15 [PMID: 14676299] (Neutralization, Mouse) </a></td> <td valign="top">Neutralization</td> <td valign="top">Mouse</td> </tr><tr class="lined revfil hidden" data-application="Neutralization" data-species="Human"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/14662842" target="_blank" rel="nofollow"> Koenen HJ, Fasse E, Joosten I IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression. J. Immunol., 2003-12-15;171(12):6431-41. 2003-12-15 [PMID: 14662842] (Neutralization, Human) </a></td> <td valign="top">Neutralization</td> <td valign="top">Human</td> </tr><tr class="lined revfil hidden" data-application="Neutralization" data-species="Mouse"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/12759459" target="_blank" rel="nofollow"> Kobayashi T, Iijima K, Kita H Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice. J. Immunol., 2003-06-01;170(11):5756-63. 2003-06-01 [PMID: 12759459] (Neutralization, Mouse) </a></td> <td valign="top">Neutralization</td> <td valign="top">Mouse</td> </tr><tr class="lined revfil hidden" data-application="Neutralization" data-species="Hamster"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/12704114" target="_blank" rel="nofollow"> Mookerjee A, Sen PC, Ghose AC Immunosuppression in hamsters with progressive visceral leishmaniasis is associated with an impairment of protein kinase C activity in their lymphocytes that can be partially reversed by okadaic acid or anti-transforming growth factor beta antibody. Infect. Immun., 2003-05-01;71(5):2439-46. 2003-05-01 [PMID: 12704114] (Neutralization, Hamster) </a></td> <td valign="top">Neutralization</td> <td valign="top">Hamster</td> </tr><tr class="lined revfil hidden" data-application="Neutralization" data-species="Chicken"> <td><a href="http://www.ncbi.nlm.nih.gov/pubmed/11781340" target="_blank" rel="nofollow"> Feugate JE, 2019, Li Q, Wong L, Martins-Green M The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. e0216795, 2002-01-07;156(1):161-72. 2002-01-07 [PMID: 11781340] (Neutralization, Chicken) </a></td> <td valign="top">Neutralization</td> <td valign="top">Chicken</td> </tr><tr><td colspan="3" align="center"> <a class="pubs_showall">Show All 226 Publications.</a> <a class="pubs_collapse" style="display:none;">Collapse Publications.</a> </td></tr></tbody> </table> </div> </div> <a id="ReviewsSection"></a> <h2 class="greyHead2">Reviews for <span>TGF beta 1/2/3 Antibody (MAB1835) (0) </span></h2> <div class="ds_info"> There are no reviews for TGF beta 1/2/3 Antibody (MAB1835). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount. <br/> <ul> <li>Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen</li> <li>Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen</li> </ul> <div class="align-right"> <a href="/reviews/MAB1835"><button class="greybutton btn_width" name="novusreview">Submit a Review</button></a><br /> </div> </div> <div class="clear"></div></div> <div class="ds_tab_content equalbottom" id="content_protocols-faqs"> <a id="protocols-faqs"></a><h2 class="greyHead2">Product General Protocols</h2> <a id="protocols"></a> <div class="ds_info">Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars. <ul><li><a href="/support/support-by-application/western-blot/protocol.html">Western Blot</a></li><li><a href="/support/support-by-application.html">View all Protocols, Troubleshooting, Illustrated assays and Webinars.</a></li> </ul></div><h2 class="greyHead2 ds_info">Video Protocols</h2> <a id="videos"></a> <div class="ds_info"><div class="movie-cell"> <span class="movie-title">WB Video Protocol</span><br/> <meta content ="https://www.youtube.com/watch?v=uFu8aie4QFI" /> <a href="https://www.youtube.com/embed/uFu8aie4QFI?rel=0&wmode=transparent" class="youtube"> <div class="reduce sprite_WBvideo"></div> </a> </div></div> <div class="clear"></div><h2 class="greyHead2">FAQs for TGF beta 1/2/3 Antibody (MAB1835) (0)</h2> <a id="faqs"></a> <div class="ds_info">There are no specific FAQs related to this product. Read our general <a href="/support/faqs.html">customer & technical service FAQs.</a> </div> <div class="clear"></div></div> <div class="ds_tab_content equalbottom" id="content_supportresearch"> <a id="supportresearch"></a><table cellpadding="0" cellspacing="0"><tr><td valign="top" class="width50"> <h2 class="greyHead2">Secondary Antibodies</h2> <a id="secondaryantibodies"></a> <div class="ds_info"> <ul class="information-list"><li><a href="/product-type/secondary-antibodies?species=Mouse&facet_conjugate=HRP">Anti-Mouse HRP Labeled Antibodies</a></li><li><a href="/product-type/secondary-antibodies?species=Mouse&facet_conjugate=FITC">Anti-Mouse FITC Labeled Antibodies</a></li><li><a href="/product-type/secondary-antibodies?species=Mouse&facet_conjugate=Biotin">Anti-Mouse Biotin Labeled Antibodies</a></li><li> </li> <li><a href="/product-type/secondary-antibodies#fq=species%3A%22Mouse%22">View all of our anti-Mouse Secondary Antibodies</a></li> </ul> </div></td><td width="5"> </td><td valign="top"> <h2 class="greyHead2" >Isotype Controls</h2> <a id="isotypecontrols"></a> <div class="ds_info"> <ul class="ds_noDotList"><li><a href="/product-type/isotype-controls#fq=species%3A%22Mouse%22">Mouse Isotype Controls</a></li><li> </li> <li><a href="/product-type/isotype-controls">View all of our Isotype Control Products</a></li> </div></td></tr></table><h2 class="greyHead2">Additional TGF beta 1/2/3 Products</h2> <a id="addtlalphaprods"></a> <div class="ds_info"> <div> <span style="display:none;">Array MAB1835</span> <ul class="ds_noDotList"><li> <a href="/primary-antibodies/tgf-beta-1-2-3">TGF beta 1/2/3 Antibodies</a></li></ul> </div> </div><table cellpadding="0" cellspacing="0" class="width100"><tr></tr></table><table cellpadding="0" cellspacing="0" class="width100"><tr></tr></table><h2 class="greyHead2">Blogs on TGF beta 1/2/3</h2> <a id="blogsect"></a> <div>There are no specific blogs for TGF beta 1/2/3, but you can <a href="/antibody-news/">read our latest blog posts.</div> <div class="clear"></div></div> </div></div><div class="grid_6"><div class="ds_blue_border marTop26 equalbottom"><a id="jump_recommended"></a> <h2 class="greyHead2">Customers Who Bought This Also Bought</h2> <div class="text_center"><div class="images2"><div class="cycle-slideshow" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-prev="#ss_prev_sidebar" data-cycle-next="#ss_next_sidebar" data-cycle-slides="div.big_thumb_container" id="ds_customer_who_bought" ><div class="big_thumb_container" data-catnums="210-TA-005"> <div class="img_container"> <a href="/products/recombinant-human-tnf-alpha-protein_210-ta" title="1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa." class="cust_bought" > <img loading="lazy" src="https://images.novusbio.com/images2/TNF-alpha_210-TA_256.jpg" title="1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa." alt="1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa." class="big_thumb" /> </a> </div> <div class="caption_container"><a href="/products/recombinant-human-tnf-alpha-protein_210-ta">TNF-alpha [Unconjugated]</a> <br />210-TA-005</div> <div style="text-align: right"><button class="greybutton" id="novusviewdatasheet" name="novusviewdatasheet" onclick="window.location='/products/recombinant-human-tnf-alpha-protein_210-ta';" >View Datasheet</button> </div> </div></div></div></div><div class="clear"></div><a id="jump_distributor"></a> <h2 class="greyHead2">Contact Information</h2> <div class="ds_info"> <div id="distributors"></div> </div> <div id="et_reload_trigger" style="display:none;">reload</div><h2 class="greyHead2">Product PDFs</h2><div class="silverHeadShort"> <span class="file"><a href="//aero.bio-techne.com/sds/pdf/mab1835" 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Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.</p> </div> <div class="calc_section"> <label for="reconstitution_calculator_volume" class="calculator_label">Volume</label> <input id="reconstitution_calculator_volume" name="reconstitution_calculator_volume" type="text" maxlength="16" placeholder="volume" class="calculator_input calculator_text"/> <select id="reconstitution_calculator_volume_unit" class="calculator_input calculator_select"> <option value="ml">ml</option> <option value="ul" selected="selected">ul</option> </select> </div> <span class="calculator_equals calculator_operator">=</span> <div class="calc_section"> <label for="reconstitution_calculator_mass" class="calculator_label">Mass</label> <input id="reconstitution_calculator_mass" name="reconstitution_calculator_mass" type="text" maxlength="16" placeholder="mass" class="calculator_input calculator_text"/> <select id="reconstitution_calculator_mass_unit" class="calculator_input calculator_select"> <option value="mg">mg</option> <option value="ug" selected="selected">ug</option> <option value="ng">ng</option> </select> </div> <span class="calculator_divide calculator_operator">÷</span> <div class="calc_section"> <label for="reconstitution_calculator_concentration" class="calculator_label">Concentration</label> <input id="reconstitution_calculator_concentration" name="reconstitution_calculator_concentration" type="text" maxlength="16" placeholder="concentration" class="calculator_input calculator_text"/> <select id="reconstitution_calculator_concentration_unit" class="calculator_input calculator_select"> <option value="mg/ml">mg/ml</option> <option value="ug/ml" selected="selected">ug/ml</option> <option value="ng/ml">ng/ml</option> </select> </div> <div id="reconstitution_foot" class="calc_section"> <input type="submit" value="Calculate" id="button_reconstitution_calculator_calculate" class="calculator_button"/> </div> </div> </div> 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<tbody> <tr class="odd"><td><div class="atc_size" title="catalog # MAB1835-SP">25 ug</div><div data-msg='' class="atc_catnum">MAB1835-SP</div></td><td><div style="font-size:11px;"><a class="jump_distributor" href="#jump_distributor">Contact Your<br />Distributor</a></div></td> </tr> <tr class="even"><td colspan="3" class="stock_row">8-10 Business Days</td> </tr> <tr class="odd"><td><div class="atc_size" title="catalog # MAB1835-100">100 ug</div><div data-msg='' class="atc_catnum">MAB1835-100</div></td><td><div style="font-size:11px;"><a class="jump_distributor" href="#jump_distributor">Contact Your<br />Distributor</a></div></td> </tr> <tr class="even"><td colspan="3" class="stock_row">4-6 Business Days</td> </tr> <tr class="odd"><td><div class="atc_size" title="catalog # MAB1835-500">500 ug</div><div data-msg='' class="atc_catnum">MAB1835-500</div></td><td><div style="font-size:11px;"><a class="jump_distributor" href="#jump_distributor">Contact Your<br />Distributor</a></div></td> 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TGF beta 1/2/3 Antibody (1D11) [Unconjugated] (MAB1835): Novus Biologicals