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class="menu-card"><div _ngcontent-sc258="" class="menu-card-header">FEATURED</div><asco-link _ngcontent-sc258="" _nghost-sc188=""><a _ngcontent-sc188="" rel="noopener" href="https://breakthrough.asco.org"><div _ngcontent-sc258="" class="menu-card-link-inner"><div _ngcontent-sc258="" class="menu-card-image" style="background-image:url(https://s3.amazonaws.com/files.oncologymeetings.org/images/BT24-Skyline-ft-hub-menu-280x145.png);"></div><div _ngcontent-sc258="" class="menu-card-title">2024 ASCO Breakthrough</div><div _ngcontent-sc258="" class="menu-card-desc">ASCO Breakthrough is your gateway to up-to-the-minute clinical research advances across multiple disease sites. 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Learn more.</div></div></a></asco-link></div></div></div><div _ngcontent-sc258="" class="hsr-submenu"><div _ngcontent-sc258="" class="hsr-submenu-items"><div _ngcontent-sc258="" data-cy="submenu-level-2" class="hsr-submenu-item"><div _ngcontent-sc258="" class="header-submenu-item header-submenu-item--back only-on-sm"><button _ngcontent-sc258="" mat-button="" class="mat-focus-indicator menu-children-title mat-button mat-button-base _mat-animation-noopable"><span class="mat-button-wrapper"><mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">keyboard_arrow_left</mat-icon> Back </span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></button></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title active"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Meetings </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://conferences.asco.org/am" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> ASCO Annual Meeting </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://conferences.asco.org/boa" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Best of ASCO </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span 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buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://conferences.asco.org/quality" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> ASCO Quality Care Symposium </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" 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class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://headandnecksymposium.org" target="_blank" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Multidisciplinary Head & Neck Symposium <mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate launch-icon-display align-middle material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">launch</mat-icon></div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.thoracicsymposium.org" target="_blank" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Multidisciplinary Thoracic Cancers Symposium <mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate launch-icon-display align-middle material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">launch</mat-icon></div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://soc-neuro-onc.org/WEB/Event_Content/2024_SNO_ASCO_CNS_Metastases_Conference.aspx" target="_blank" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> SNO/ASCO CNS Metastases Conference <mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate launch-icon-display align-middle material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">launch</mat-icon></div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://vailworkshop.org" target="_blank" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> AACR/ASCO Methods in Clinical Cancer Research Workshop <mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate launch-icon-display align-middle material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">launch</mat-icon></div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/meeting-slides-videos" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Meeting Slides & Videos </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div></div><div _ngcontent-sc258="" class="hsr-submenu-item hsr-submenu-item--highlight"><div _ngcontent-sc258="" class="menu-subchildren-helplinks"><div _ngcontent-sc258="" class="menu-subchildren-title">HELPFUL LINKS</div><ul _ngcontent-sc258="" class="menu-subchildren-items"><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/abstract-submissions" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Submit an Abstract </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/exhibitor-advertiser-information" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Exhibitor Information </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/joint-sessions-endorsements" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Joint Sessions & Endorsements </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li></ul></div></div></div></div><div _ngcontent-sc258="" class="hsr-submenu"><div _ngcontent-sc258="" class="hsr-submenu-items"><div _ngcontent-sc258="" data-cy="submenu-level-2" class="hsr-submenu-item"><div _ngcontent-sc258="" class="header-submenu-item header-submenu-item--back only-on-sm"><button _ngcontent-sc258="" mat-button="" class="mat-focus-indicator menu-children-title mat-button mat-button-base _mat-animation-noopable"><span class="mat-button-wrapper"><mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">keyboard_arrow_left</mat-icon> Back </span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></button></div></div><div _ngcontent-sc258="" class="hsr-submenu-item hsr-submenu-item--highlight"><div _ngcontent-sc258="" class="menu-subchildren-helplinks"><div _ngcontent-sc258="" class="menu-subchildren-title">HELPFUL LINKS</div><ul _ngcontent-sc258="" class="menu-subchildren-items"><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/abstract-submissions" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Submit an Abstract </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/exhibitor-advertiser-information" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Exhibitor Information </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/joint-sessions-endorsements" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Joint Sessions & Endorsements </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li></ul></div></div></div></div><div _ngcontent-sc258="" class="hsr-submenu"><div _ngcontent-sc258="" class="hsr-submenu-items"><div _ngcontent-sc258="" data-cy="submenu-level-2" class="hsr-submenu-item"><div _ngcontent-sc258="" class="header-submenu-item header-submenu-item--back only-on-sm"><button _ngcontent-sc258="" mat-button="" class="mat-focus-indicator menu-children-title mat-button mat-button-base _mat-animation-noopable"><span class="mat-button-wrapper"><mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">keyboard_arrow_left</mat-icon> Back </span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></button></div></div><div _ngcontent-sc258="" class="hsr-submenu-item hsr-submenu-item--highlight"><div _ngcontent-sc258="" class="menu-subchildren-helplinks"><div _ngcontent-sc258="" class="menu-subchildren-title">HELPFUL LINKS</div><ul _ngcontent-sc258="" class="menu-subchildren-items"><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/abstract-submissions" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Submit an Abstract </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/exhibitor-advertiser-information" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Exhibitor Information </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/joint-sessions-endorsements" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Joint Sessions & Endorsements </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li></ul></div></div></div></div><div _ngcontent-sc258="" class="hsr-submenu"><div _ngcontent-sc258="" class="hsr-submenu-items"><div _ngcontent-sc258="" data-cy="submenu-level-2" class="hsr-submenu-item"><div _ngcontent-sc258="" class="header-submenu-item header-submenu-item--back only-on-sm"><button _ngcontent-sc258="" mat-button="" class="mat-focus-indicator menu-children-title mat-button mat-button-base _mat-animation-noopable"><span class="mat-button-wrapper"><mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">keyboard_arrow_left</mat-icon> Back </span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></button></div></div><div _ngcontent-sc258="" class="hsr-submenu-item hsr-submenu-item--highlight"><div _ngcontent-sc258="" class="menu-subchildren-helplinks"><div _ngcontent-sc258="" class="menu-subchildren-title">HELPFUL LINKS</div><ul _ngcontent-sc258="" class="menu-subchildren-items"><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/abstract-submissions" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Submit an Abstract </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/exhibitor-advertiser-information" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Exhibitor Information </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/joint-sessions-endorsements" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Joint Sessions & Endorsements </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li></ul></div></div></div></div><div _ngcontent-sc258="" class="hsr-submenu"><div _ngcontent-sc258="" class="hsr-submenu-items"><div _ngcontent-sc258="" data-cy="submenu-level-2" class="hsr-submenu-item"><div _ngcontent-sc258="" class="header-submenu-item header-submenu-item--back only-on-sm"><button _ngcontent-sc258="" mat-button="" class="mat-focus-indicator menu-children-title mat-button mat-button-base _mat-animation-noopable"><span class="mat-button-wrapper"><mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">keyboard_arrow_left</mat-icon> Back </span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></button></div></div><div _ngcontent-sc258="" class="hsr-submenu-item hsr-submenu-item--highlight"><div _ngcontent-sc258="" class="menu-subchildren-helplinks"><div _ngcontent-sc258="" class="menu-subchildren-title">HELPFUL LINKS</div><ul _ngcontent-sc258="" class="menu-subchildren-items"><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/abstract-submissions" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Submit an Abstract </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/exhibitor-advertiser-information" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Exhibitor Information </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/joint-sessions-endorsements" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Joint Sessions & Endorsements </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li></ul></div></div></div></div><div _ngcontent-sc258="" class="hsr-submenu"><div _ngcontent-sc258="" class="hsr-submenu-items"><div _ngcontent-sc258="" data-cy="submenu-level-2" class="hsr-submenu-item"><div _ngcontent-sc258="" class="header-submenu-item header-submenu-item--back only-on-sm"><button _ngcontent-sc258="" mat-button="" class="mat-focus-indicator menu-children-title mat-button mat-button-base _mat-animation-noopable"><span class="mat-button-wrapper"><mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">keyboard_arrow_left</mat-icon> Back </span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></button></div></div><div _ngcontent-sc258="" class="hsr-submenu-item hsr-submenu-item--highlight"><div _ngcontent-sc258="" class="menu-subchildren-helplinks"><div _ngcontent-sc258="" class="menu-subchildren-title">HELPFUL LINKS</div><ul _ngcontent-sc258="" class="menu-subchildren-items"><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/abstract-submissions" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Submit an Abstract </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/exhibitor-advertiser-information" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Exhibitor Information </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/joint-sessions-endorsements" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Joint Sessions & Endorsements </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li></ul></div></div></div></div><div _ngcontent-sc258="" class="hsr-submenu"><div _ngcontent-sc258="" class="hsr-submenu-items"><div _ngcontent-sc258="" data-cy="submenu-level-2" class="hsr-submenu-item"><div _ngcontent-sc258="" class="header-submenu-item header-submenu-item--back only-on-sm"><button _ngcontent-sc258="" mat-button="" class="mat-focus-indicator menu-children-title mat-button mat-button-base _mat-animation-noopable"><span class="mat-button-wrapper"><mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">keyboard_arrow_left</mat-icon> Back </span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></button></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title active"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/training-programs" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Training Programs </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://asco.org/meetings-education/training-programs/quality-training-program" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Quality Training Program </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/training-programs/global-courses" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Global Courses </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/training-programs/global-curriculum" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Global Curriculum Recommendations </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/training-programs/medical-oncology-training-examination" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Medical Oncology In-Training Examination </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/training-programs/resilience-skills-training-program" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Resilience Skills Training Program </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/training-programs/combined-hematology-oncology-hospice-palliative-medicine-training" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Combined Hematology/Oncology and Hospice & Palliative Medicine Training </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div></div><div _ngcontent-sc258="" class="hsr-submenu-item hsr-submenu-item--highlight"><div _ngcontent-sc258="" class="menu-subchildren-helplinks"><div _ngcontent-sc258="" class="menu-subchildren-title">HELPFUL LINKS</div><ul _ngcontent-sc258="" class="menu-subchildren-items"><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/abstract-submissions" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Submit an Abstract </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/exhibitor-advertiser-information" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Exhibitor Information </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/joint-sessions-endorsements" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Joint Sessions & Endorsements </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li></ul></div></div></div></div><div _ngcontent-sc258="" class="hsr-submenu"><div _ngcontent-sc258="" class="hsr-submenu-items"><div _ngcontent-sc258="" data-cy="submenu-level-2" class="hsr-submenu-item"><div _ngcontent-sc258="" class="header-submenu-item header-submenu-item--back only-on-sm"><button _ngcontent-sc258="" mat-button="" class="mat-focus-indicator menu-children-title mat-button mat-button-base _mat-animation-noopable"><span class="mat-button-wrapper"><mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">keyboard_arrow_left</mat-icon> Back </span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></button></div></div><div _ngcontent-sc258="" class="hsr-submenu-item hsr-submenu-item--highlight"><div _ngcontent-sc258="" class="menu-subchildren-helplinks"><div _ngcontent-sc258="" class="menu-subchildren-title">HELPFUL LINKS</div><ul _ngcontent-sc258="" class="menu-subchildren-items"><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/abstract-submissions" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Submit an Abstract </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/meetings-education/meetings/exhibitor-advertiser-information" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><span _ngcontent-sc258="" class="menu-subchildren-item-inner"> Exhibitor Information </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></li><li _ngcontent-sc258="" class="menu-subchildren-item"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" 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mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/practice-patients/cancer-care-standards/standards-safe-handling-hazardous-drugs" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Standards for Safe Handling of Hazardous Drugs </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" 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mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/news-initiatives" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> News & Initiatives </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/news-initiatives/policy-news-analysis" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div 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Back </span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></button></div></div></div></div><div _ngcontent-sc258="" class="hsr-submenu"><div _ngcontent-sc258="" class="hsr-submenu-items"><div _ngcontent-sc258="" data-cy="submenu-level-2" class="hsr-submenu-item"><div _ngcontent-sc258="" class="header-submenu-item header-submenu-item--back only-on-sm"><button _ngcontent-sc258="" mat-button="" class="mat-focus-indicator menu-children-title mat-button mat-button-base _mat-animation-noopable"><span class="mat-button-wrapper"><mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">keyboard_arrow_left</mat-icon> Back </span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></button></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title active"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/news-initiatives/current-initiatives" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Current Initiatives </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/news-initiatives/current-initiatives/policy-issues-statements" tabindex="0" aria-disabled="false"><span class="mat-button-wrapper"><div _ngcontent-sc258="" class="template-withRouterLink"> Policy Issues & Statements </div></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></a></asco-link></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><asco-link _ngcontent-sc258="" cssclass="mat-basic-button d-inline-block no-hover" buttoncolor="basic" _nghost-sc188=""><a _ngcontent-sc188="" mat-button="" rel="noopener" class="mat-focus-indicator mat-button mat-button-base mat-basic mat-basic-button d-inline-block no-hover _mat-animation-noopable" href="https://www.asco.org/news-initiatives/current-initiatives/health-equity" tabindex="0" 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Committees <mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate align-middle material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">chevron_right</mat-icon></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></button></span></div><div _ngcontent-sc258="" class="header-submenu-item"><span _ngcontent-sc258="" class="menu-title"><button _ngcontent-sc258="" data-cy="submenu-button" mat-button="" class="mat-focus-indicator d-inline-block mat-button mat-button-base _mat-animation-noopable"><span class="mat-button-wrapper"> ASCO Patient Advocacy Programs & Opportunities <mat-icon _ngcontent-sc258="" role="img" class="mat-icon notranslate align-middle material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">chevron_right</mat-icon></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span 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class="mat-list-item-content"><div mat-ripple="" class="mat-ripple mat-list-item-ripple"></div><mat-icon _ngcontent-sc318="" role="img" mat-list-icon="" class="mat-icon notranslate mat-list-icon material-icons mat-icon-no-color ng-star-inserted" aria-hidden="true" data-mat-icon-type="font">note</mat-icon><div class="mat-list-text"></div><h5 _ngcontent-sc318="" class="mb-0 mx-3">Poster</h5></div></mat-list-item></a></asco-link></mat-nav-list><hr _ngcontent-sc318="" class="d-none d-lg-block"></div></asco-vertical-tab-navigation></div></asco-side-navigation><asco-abstract-details _ngcontent-sc329="" class="col-xs-12 abstract-details w-100 ng-star-inserted" _nghost-sc321=""><div _ngcontent-sc321="" class="ng-star-inserted"><asco-label-value-list _ngcontent-sc321="" class="col-xs-12" _nghost-sc320=""><h4 _ngcontent-sc320="">Details</h4><ul _ngcontent-sc320="" class="m-0 p-0"><li _ngcontent-sc320="" class="label-value-list__item ng-star-inserted"><div _ngcontent-sc320="" class="ng-star-inserted"><p _ngcontent-sc320="" class="label-value-list__item__label">First Author</p><asco-link _ngcontent-sc320="" _nghost-sc188="" class="ng-star-inserted"><a _ngcontent-sc188="" title="Rahul Raj Aggarwal " href="/abstracts-presentations/search?q=Rahul%20Raj%20Aggarwal%20" target="_self" class="ng-star-inserted"><span _ngcontent-sc320="" class="ng-star-inserted">Rahul Raj Aggarwal </span></a></asco-link></div></li><li _ngcontent-sc320="" class="label-value-list__item ng-star-inserted"><div _ngcontent-sc320="" class="ng-star-inserted"><p _ngcontent-sc320="" class="label-value-list__item__label">Meeting</p><asco-link _ngcontent-sc320="" _nghost-sc188="" class="ng-star-inserted"><a _ngcontent-sc188="" title="2021 ASCO Annual Meeting" href="/abstracts-presentations/search?q=*&filters=%7B%22meetingTypeName%22:%5B%7B%22key%22:%22ASCO%20Annual%20Meeting%22%7D%5D,%22meetingYear%22:%5B%7B%22key%22:%222021%22%7D%5D%7D" target="_self" class="ng-star-inserted"><span _ngcontent-sc320="" class="ng-star-inserted">2021 ASCO Annual Meeting</span></a></asco-link></div></li><li _ngcontent-sc320="" class="label-value-list__item ng-star-inserted"><div _ngcontent-sc320="" class="ng-star-inserted"><p _ngcontent-sc320="" class="label-value-list__item__label">Session Type</p><asco-link _ngcontent-sc320="" _nghost-sc188="" class="ng-star-inserted"><a _ngcontent-sc188="" title="Poster Session" href="/abstracts-presentations/search?q=*&filters=%7B%22sessionType%22:%5B%7B%22key%22:%22Poster%20Session%22%7D%5D%7D" target="_self" class="ng-star-inserted"><span _ngcontent-sc320="" class="ng-star-inserted">Poster Session</span></a></asco-link></div></li><li _ngcontent-sc320="" class="label-value-list__item ng-star-inserted"><div _ngcontent-sc320="" class="ng-star-inserted"><p _ngcontent-sc320="" class="label-value-list__item__label">Session Title</p><asco-link _ngcontent-sc320="" _nghost-sc188="" class="ng-star-inserted"><a _ngcontent-sc188="" title="Genitourinary Cancer—Prostate, Testicular, and Penile" href="/2021-asco-annual-meeting/13633?presentation=197915#197915" target="_blank" class="ng-star-inserted"><span _ngcontent-sc320="" class="ng-star-inserted">Genitourinary Cancer—Prostate, Testicular, and Penile</span></a></asco-link></div></li><li _ngcontent-sc320="" class="label-value-list__item ng-star-inserted"><div _ngcontent-sc320="" class="ng-star-inserted"><p _ngcontent-sc320="" class="label-value-list__item__label">Track</p><asco-link _ngcontent-sc320="" _nghost-sc188="" class="ng-star-inserted"><a _ngcontent-sc188="" title="Genitourinary Cancer—Prostate, Testicular, and Penile" href="/abstracts-presentations/search?q=*&filters=%7B%22track%22:%5B%7B%22key%22:%22Genitourinary%20Cancer%E2%80%94Prostate,%20Testicular,%20and%20Penile%22%7D%5D%7D" target="_self" class="ng-star-inserted"><span _ngcontent-sc320="" class="ng-star-inserted">Genitourinary Cancer—Prostate, Testicular, and Penile</span></a></asco-link></div></li><li _ngcontent-sc320="" class="label-value-list__item ng-star-inserted"><div _ngcontent-sc320="" class="ng-star-inserted"><p _ngcontent-sc320="" class="label-value-list__item__label">Sub Track</p><asco-link _ngcontent-sc320="" _nghost-sc188="" class="ng-star-inserted"><a _ngcontent-sc188="" title="Prostate Cancer– Advanced/Castrate-Resistant" href="/abstracts-presentations/search?q=*&filters=%7B%22track%22:%5B%7B%22key%22:%22Prostate%20Cancer%E2%80%93%20Advanced%2FCastrate-Resistant%22%7D%5D%7D" target="_self" class="ng-star-inserted"><span _ngcontent-sc320="" class="ng-star-inserted">Prostate Cancer– Advanced/Castrate-Resistant</span></a></asco-link></div></li><li _ngcontent-sc320="" class="label-value-list__item ng-star-inserted"><div _ngcontent-sc320="" class="ng-star-inserted"><p _ngcontent-sc320="" class="label-value-list__item__label">Clinical Trial Registration Number</p><p _ngcontent-sc320="" class="label-value-list__item__value ng-star-inserted">NCT03805594</p></div></li><li _ngcontent-sc320="" class="label-value-list__item ng-star-inserted"><div _ngcontent-sc320="" class="ng-star-inserted"><p _ngcontent-sc320="" class="label-value-list__item__label">Citation</p><p _ngcontent-sc320="" class="label-value-list__item__value ng-star-inserted">J Clin Oncol 39, 2021 (suppl 15; abstr 5053)</p></div></li><li _ngcontent-sc320="" class="label-value-list__item ng-star-inserted"><div _ngcontent-sc320="" class="ng-star-inserted"><p _ngcontent-sc320="" class="label-value-list__item__label">DOI</p><asco-link _ngcontent-sc320="" _nghost-sc188="" class="ng-star-inserted"><a _ngcontent-sc188="" rel="noopener" href="https://doi.org/10.1200/JCO.2021.39.15_suppl.5053" target="_blank" title="10.1200/JCO.2021.39.15_suppl.5053" class="ng-star-inserted"><span _ngcontent-sc320="" class="ng-star-inserted">10.1200/JCO.2021.39.15_suppl.5053</span></a></asco-link></div></li><li _ngcontent-sc320="" class="label-value-list__item ng-star-inserted"><div _ngcontent-sc320="" class="ng-star-inserted"><p _ngcontent-sc320="" class="label-value-list__item__label">Abstract #</p><p _ngcontent-sc320="" class="label-value-list__item__value ng-star-inserted">5053</p></div></li><li _ngcontent-sc320="" class="label-value-list__item ng-star-inserted"><div _ngcontent-sc320="" class="ng-star-inserted"><p _ngcontent-sc320="" class="label-value-list__item__label">Poster Bd #</p><p _ngcontent-sc320="" class="label-value-list__item__value ng-star-inserted">Online Only</p></div></li></ul></asco-label-value-list></div></asco-abstract-details></div></div></div><div _ngcontent-sc329="" class="col-md-1 col-lg-1"></div><div _ngcontent-sc329="" class="presentation_details__main col-md-7 col-lg-8"><asco-abstract _ngcontent-sc329="" _nghost-sc324="" class="ng-star-inserted"><div _ngcontent-sc324="" class="ng-star-inserted"><div _ngcontent-sc324="" class="presentation-details__abstract_container ng-star-inserted"><h4 _ngcontent-sc324="" text-asco-black="">Authors</h4><div _ngcontent-sc324="" class="ng-star-inserted"><asco-profile-card _ngcontent-sc324="" _nghost-sc323=""><div _ngcontent-sc323="" class="d-flex mb-2 profile-card"><span _ngcontent-sc323=""><asco-avatar _ngcontent-sc323="" _nghost-sc187=""><div _ngcontent-sc187="" class="avatar"><div _ngcontent-sc187="" class="avatar__image-container small"><mat-icon _ngcontent-sc187="" role="img" aria-hidden="false" class="mat-icon notranslate material-icons mat-icon-no-color ng-star-inserted" aria-label="Avatar Image" data-mat-icon-type="font">person</mat-icon></div></div></asco-avatar></span><span _ngcontent-sc323="" class="ml-2 w-100 align-self-center avatar-info"><h5 _ngcontent-sc323="" class="m-0 p-0 text-14">Rahul Raj Aggarwal </h5><p _ngcontent-sc323="" class="m-0 p-0 text-12">University of California, San Francisco, San Francisco, CA</p></span><div _ngcontent-sc323="" class="pwa-overlay"><asco-pwa-overlay-trigger _ngcontent-sc323="" _nghost-sc191=""><div _ngcontent-sc191=""><button _ngcontent-sc191="" mat-button="" class="mat-focus-indicator menu__item mat-button mat-button-base _mat-animation-noopable"><span class="mat-button-wrapper"><mat-icon _ngcontent-sc191="" role="img" class="mat-icon notranslate material-icons mat-icon-no-color" aria-hidden="true" data-mat-icon-type="font">info_outline</mat-icon><span _ngcontent-sc191="" class="menu__item__text"> </span></span><span matripple="" class="mat-ripple mat-button-ripple"></span><span class="mat-button-focus-overlay"></span></button></div></asco-pwa-overlay-trigger></div></div></asco-profile-card></div><p _ngcontent-sc324="" class="mt-3 mb-4 ng-star-inserted"><asco-safe-html _ngcontent-sc324="" _nghost-sc273=""><div _ngcontent-sc273="" class="safe-html">Rahul Raj Aggarwal , Srey Luch Sam , Vadim S Koshkin , Eric Jay Small , Felix Y Feng , Ivan de Kouchkovsky , Daniel H Kwon , Terence W. Friedlander , Hala Borno , Rohit Bose , Jonathan Chou , Arpita Desai , Tammy J. Rodvelt , Maya Aslam , Medini Rastogi , Lawrence Fong , Thomas A Hope </div></asco-safe-html></p><h6 _ngcontent-sc324="" class="ng-star-inserted">Organizations</h6><p _ngcontent-sc324="" class="ng-star-inserted"><asco-safe-html _ngcontent-sc324="" _nghost-sc273=""><div _ngcontent-sc273="" class="safe-html">University of California, San Francisco, San Francisco, CA, University of California San Francisco, San Francisco, CA, University of California San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, UCSF, San Francisco, CA, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA</div></asco-safe-html></p><asco-link _ngcontent-sc324="" _nghost-sc188="" class="ng-star-inserted"><a _ngcontent-sc188="" rel="noopener" href="https://coi.asco.org/Report/ViewAbstractCOI?id=339297" class="ng-star-inserted">Abstract Disclosures</a></asco-link><div _ngcontent-sc324="" class="mt-5 ng-star-inserted"><h4 _ngcontent-sc324="">Research Funding</h4><p _ngcontent-sc324="" class="mb-0"><asco-safe-html _ngcontent-sc324="" _nghost-sc273="" class="ng-star-inserted"><div _ngcontent-sc273="" class="safe-html">U.S. National Institutes of Health</div></asco-safe-html><asco-safe-html _ngcontent-sc324="" _nghost-sc273="" class="ng-star-inserted"><div _ngcontent-sc273="" class="safe-html">U.S. National Institutes of Health, Other Foundation, Philanthropic gift - Gene and Ethel Daly</div></asco-safe-html></p></div><asco-safe-html _ngcontent-sc324="" _nghost-sc273="" class="ng-star-inserted"><div _ngcontent-sc273="" class="safe-html"><p> <b>Background:</b> Immune checkpoint inhibitors have limited single agent activity in microsatellite-stable mCRPC. <sup>177</sup>Lu-PSMA-617 (Lu) is a PSMA-targeting radioligand therapy that has demonstrated promising anti-tumor activity. We sought to determine whether a single dose of Lu can induce an immunogenic priming effect to improve outcomes of men with mCRPC subsequently treated with pembrolizumab (P). <b>Methods:</b> We undertook a phase 1b, single arm trial enrolling chemotherapy-naïve mCRPC patients (pts) with progression (PD) on at least one prior androgen signaling inhibitor (NCT03805594). Pts were required to have ≥ 3 PSMA-avid lesions on <sup>68</sup>Ga-PSMA-11 PET and measurable disease by RECIST 1.1 criteria. No genomic selection was undertaken. Pts were enrolled sequentially on one of three schedules: A) Single dose of Lu (7.4 GBq) followed by initiation of P (200 mg IV q 3 weeks) 28 days later; B) Lu x 1 dose given concomitantly with first P administration; C) Lu x 1 dose given on C2D1 following initiation of P on C1D1. Pts were treated with P until confirmed radiographic or clinical PD. The primary endpoint was safety; key secondary endpoints included PSA response, objective response rate by RECIST 1.1 criteria (ORR), median duration of response (DOR), and radiographic progression-free survival (rPFS). <b>Results:</b> 18 pts were enrolled, 6 per schedule. The median age was 64 (range 51 – 80) and 44% of pts had visceral metastases. The median baseline number of PSMA-avid metastatic lesions was 20 (range 6 – 50+). Six pts (33%) had progressed on prior abiraterone, 4 (22%) on enzalutamide, and 8 (44%) on both. There were no dose-limiting toxicities and one Grade ≥ 3 treatment-related adverse event (AE) (inflammatory arthritis, schedule B). There were no grade ≥ 3 hematologic AEs. The ORR was 8/18 (44%) and median DOR has not been reached (range 1.9+ – 15.9+ months). Four pts (2 on schedule A, 1 on schedule B, 1 on schedule C) with durable partial responses remain on study treatment for 5.4+, 8.9+, 9.2+, and 17.8+ months, respectively. The median rPFS was 6.5 months (95% CI: 2.5 – 9.8). PSA30, PSA50, and PSA90 response rates were 44%, 28%, and 17%, respectively. Fourteen pts (78%), including all durable responders, had somatic genomic data available. One (7%) harbored a DNA repair mutation (<i>BRCA1</i>, non-responder), none were MSI-high, and all carried low tumor mutational burden (≤ 5 mutations/MB). Single cell sequencing of the immune microenvironment from paired metastatic tumor biopsies is underway. <b>Conclusions:</b><sup>177</sup>Lu-PSMA-617 as a priming dose followed by pembrolizumab was well tolerated and leads to durable responses in a subset of mCRPC without high mutational burden or microsatellite instability, suggesting a possible immunogenic priming effect of radioligand therapy. Further evaluation of the combination is ongoing in a phase 2 study. Clinical trial information: <a href="http://clinicaltrials.gov/show/NCT03805594">NCT03805594</a></p></div></asco-safe-html></div></div></asco-abstract><div _ngcontent-sc329="" class="py-3 ng-star-inserted"><div _ngcontent-sc329="" class="font-italic"> This material on this page is ©2024 American Society of Clinical Oncology, all rights reserved. Licensing available upon request. 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Rodvelt &q;,&q;publicationOrganization&q;:&q;University of California San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco, CA&q;,&q;contactPresenterUrl&q;:{&q;path&q;:&q;/AM2021/Session#/compose-message/38768&q;,&q;target&q;:null,&q;title&q;:null,&q;fqdn&q;:&q;meetingnetworking.asco.org&q;,&q;queryParams&q;:&q;{}&q;,&q;__typename&q;:&q;Url&q;},&q;profile&q;:{&q;personalInfo&q;:{&q;fullNameWithDesignation&q;:&q;Tammy J. 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We sought to determine whether a single dose of Lu can induce an immunogenic priming effect to improve outcomes of men with mCRPC subsequently treated with pembrolizumab (P). &l;b&g;Methods:&l;/b&g; We undertook a phase 1b, single arm trial enrolling chemotherapy-na&a;#x00EF;ve mCRPC patients (pts) with progression (PD) on at least one prior androgen signaling inhibitor (NCT03805594). Pts were required to have &a;#x2265; 3 PSMA-avid lesions on &l;sup&g;68&l;/sup&g;Ga-PSMA-11 PET and measurable disease by RECIST 1.1 criteria. No genomic selection was undertaken. Pts were enrolled sequentially on one of three schedules: A) Single dose of Lu (7.4 GBq) followed by initiation of P (200 mg IV q 3 weeks) 28 days later; B) Lu x 1 dose given concomitantly with first P administration; C) Lu x 1 dose given on C2D1 following initiation of P on C1D1. Pts were treated with P until confirmed radiographic or clinical PD. The primary endpoint was safety; key secondary endpoints included PSA response, objective response rate by RECIST 1.1 criteria (ORR), median duration of response (DOR), and radiographic progression-free survival (rPFS). &l;b&g;Results:&l;/b&g; 18 pts were enrolled, 6 per schedule. The median age was 64 (range 51 &a;#x2013; 80) and 44% of pts had visceral metastases. The median baseline number of PSMA-avid metastatic lesions was 20 (range 6 &a;#x2013; 50+). Six pts (33%) had progressed on prior abiraterone, 4 (22%) on enzalutamide, and 8 (44%) on both. There were no dose-limiting toxicities and one Grade &a;#x2265; 3 treatment-related adverse event (AE) (inflammatory arthritis, schedule B). There were no grade &a;#x2265; 3 hematologic AEs. The ORR was 8/18 (44%) and median DOR has not been reached (range 1.9+ &a;#x2013; 15.9+ months). Four pts (2 on schedule A, 1 on schedule B, 1 on schedule C) with durable partial responses remain on study treatment for 5.4+, 8.9+, 9.2+, and 17.8+ months, respectively. The median rPFS was 6.5 months (95% CI: 2.5 &a;#x2013; 9.8). PSA30, PSA50, and PSA90 response rates were 44%, 28%, and 17%, respectively. Fourteen pts (78%), including all durable responders, had somatic genomic data available. One (7%) harbored a DNA repair mutation (&l;i&g;BRCA1&l;/i&g;, non-responder), none were MSI-high, and all carried low tumor mutational burden (&a;#x2264; 5 mutations/MB). Single cell sequencing of the immune microenvironment from paired metastatic tumor biopsies is underway. &l;b&g;Conclusions:&l;/b&g;&l;sup&g;177&l;/sup&g;Lu-PSMA-617 as a priming dose followed by pembrolizumab was well tolerated and leads to durable responses in a subset of mCRPC without high mutational burden or microsatellite instability, suggesting a possible immunogenic priming effect of radioligand therapy. Further evaluation of the combination is ongoing in a phase 2 study. 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