HumanCyc: Encyclopedia of Human Genes and Metabolism

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</div> <div class="pure-u-lg-7-12 pure-u-md-7-12 pure-u-sm-1-1" style="height: 49px"> <div class="login pure-g" id="loginMenuBar">  <div id='subscriptionBanner' style="display:flex;flex-direction:row;justify-content: space-around;width:100%"> </div> <script type='text/javascript'> ajaxUpdater('subscriptionBanner', '/subscription-banner'); </script> </div> </div>  <div style="text-align: left; float: right; position: relative; left: 0;"> </div> </div> </div> </div> </div>     <div id="msgPopup"></div>   <div class="content" role="main" style= "margin-top:0"> <homepage-section1> <span slot="logo"> <a href="https://humancyc.org" class="bannerLogo"> <img src="/graphics2021/HumanCyc-logo-color.svg" alt="HumanCyc"> </a> </span> </homepage-section1>  <div class="whitespace-wide-margin-border" style="margin-top: 40px"> <div class="pure-g">  <div class="pure-u-xl-1-2 pure-u-lg-1-1 pure-u-md-1-1 pure-u-sm-1-1" style="margin-bottom: 10px">  <div class="dispatchSlides"> <div class="slide"> <div class="slideText"> <h3 class="whitespace-none">Heme, Not Just the Red Pigment in Blood.</h3> <h3 class="subhead"><i>Heme</i>, an iron-containing porphyrin, functions as a prosthetic group in numerous proteins. These range from components of the electron transport chain to many enzymes. No wonder the biosynthesis of <i>heme</i> is highly conserved in evolution!</h3> <p style="line-height: 0.7em"> <a href="/HUMAN/NEW-IMAGE?type=PATHWAY&object=PWY-5920" class="learn-more-href" aria-label="Learn more about heme biosynthesis" >Learn More</a> </p> </div> <div class="slidePic"> <img src="dispatchImages/bloodcells-2.jpg" alt="Scanning Electron Microscope Image of Blood Cells" width="582px" height="291px" > <p class="caption">Scanning Electron Microscope Image of Blood Cells, <a href="https://visualsonline.cancer.gov/details.cfm?imageid=2129">put in the public domain by NCI/Donald BlissBruce Wetzel and Harry Schaefer</a>.</p> </div> </div> <div class="slide"> <div class="slideText"> <h3 class="whitespace-none">Navigate Metabolic Map for Pathways</h3> <h3 class="subhead">The Cellular Overview enables you to browse through a zoomable metabolic map diagram that displays pathways according to groups based on biological function, or classes of metabolites produced/consumed. </h3> <p style="line-height: 0.7em"> <a href="http://biocyc.org/PToolsWebsiteHowto.shtml#celOverview" class="learn-more-href" aria-label="Learn more about the cellular overview diagram" >Learn More</a> </p> </div> <div class="slidePic"> <picture> <source srcset="/dispatchImages/cellov2.webp" type="image/webp"> <img class="pure-img" src="/dispatchImages/cellov2.png" alt="a portion of a Cellular Overview diagram, showing several pathway classes" width="582px" height="279px" > </picture> <p class="caption">Cellular overview image generated by Pathway Tools</p> </div> </div>  <div class="slide"> <div class="slideText"> <h3 class="whitespace-none">Important Mammalian Pathways: The Urea Cycle</h3> <h3 class="subhead"> The <i>urea cycle</i> is responsible for mediating excretion of nitrogenous waste. It was the first metabolic pathway to be discovered, five years before the discovery of the <i>TCA cycle</i>. The cycle occurs across both the cytosol and the mitchondrion. </h3> <p style="line-height: 0.7em"> <a href="/HUMAN/new-image?type=PATHWAY&object=PWY-4984" class="learn-more-href" aria-label="Learn more about the urea cycle" >Learn More</a> </p> </div> <div class="slidePic"> <img src="dispatchImages/Mitochondria-colorized.jpg" alt="colorized electron micrograph of mitochondria in a mammalian lung cell" width="582" height="291" > <p class="caption">colorized selection from <i>Mitochondria, mammalian lung - TEM</i><a href="http://en.wikipedia.org/wiki/File:Mitochondria,_mammalian_lung_-_TEM.jpg">put in the Public Domain by author, Louisa Howard</a>.</p> </div> </div> <div class="slide"> <div class="slideText"> <h3 class="whitespace-none">RouteSearch: Search for Paths through the Metabolic Network</h3> <h3 class="subhead">Search for lowest-cost paths through the metabolic network of the selected organism. Or, design lowest-cost pathways to novel compounds by adding reactions from MetaCyc.</h3> <p style="line-height: 0.7em"> <a href="/PToolsWebsiteHowto.shtml#route_search" class="learn-more-href" aria-label="Learn more about RouteSearch">Learn More</a> </p></div> <div class="slidePic"> <picture>  <source srcset="/dispatchImages/routeSearch-w581.webp" type="image/webp">  <img class="pure-img" src="/dispatchImages/routeSearch-w581.png" alt="a schematic showing 3 hypothetical routes from one compound to another, one that is very long, one that is short but most of the atoms from the starting compound do not end up in the target compound, and the best route, which is intermediate in length but conserves the atoms in the starting compound." width="582px" height="282px" > </picture> <p class="caption">.</p> </div> </div> <div class="slide"> <div class="slideText"> <h3 class="whitespace-none">A Pathway Linked to Central Nervous System Disorders</h3> <h3 class="subhead">The GABA shunt forms a closed loop in the CNS for conserving the supply of the excitatory neurotransmitter GABA. One of the enzymes of this pathway, 4-aminobutyrate aminotransferase is a target for the anti-epileptic drug vigabatrin.</h3> <p style="line-height: 0.7em"> <a href="/HUMAN/new-image?type=PATHWAY&object=GLUDEG-I-PWY" class="learn-more-href" aria-label="Learn more about the GABA shunt" >Learn More</a> </div> <div class="slidePic"> <img src="dispatchImages/brain-mri.jpg" alt="Brain MRI" width="582px" height="291px"> <p class="caption">selection from <i>Brain MRI</i><a href="https://visualsonline.cancer.gov/details.cfm?imageid=2416"> <b>Source:</b> Dr. Leon Kaufman. UCSF.</a></p> </div> </div> <div class="slide"> <div class="slideText"> <h3 class="whitespace-none">Metabolomics Data Analysis</h3> <h3 class="subhead">Multiple tools are available in this website for metabolomics data analysis.</h3> <p style="line-height: 0.7em"> <a href="/PToolsWebsiteHowto.shtml#omicsDataAnalysis" class="learn-more-href" aria-label="Learn more about omics data analysis" >Learn More</a> </p> </div> <div class="slidePic"> <img src="/dispatchImages/enrichmentDialog.png" alt="Enrichment dialog displayed over SmartTable" width="582px" height="291px"> <p class="caption">SmartTable display generated by Pathway Tools.</p> </div> </div> <div class="slide"> <div class="slideText"> <h3 class="whitespace-none">The Truth about the Thanksgiving Turkey...</h3> <h3 class="subhead">Of the 20 amino acids, at least 9 are essential. Essential L-tryptophan is required for serotonin, melatonin and niacin synthesis. Its requirement for NAD biosynthesis was discovered when humans stricken with pellagra recovered after the addition of tryptophan or niacin to their diets. </h3> <p style="line-height: 0.7em"> <a href="/HUMAN/NEW-IMAGE?type=PATHWAY&object=NADSYN-PWY" class="learn-more-href" aria-label="Learn more about synthesis of NAD from tryptophan" >Learn More</a> </p> </div> <div class="slidePic"> <img src="dispatchImages/turkey.jpg" alt="photo of a roast turkey" width="582px" height="292px"> <p class="caption"><a href="http://creativecommons.org/licenses/by-sa/2.0/">Some rights reserved</a> by <a href="http://www.flickr.com/photos/quoimedia/">QUOI Media</a>.</p> </div> </div> <div class="slide"> <div class="slideText"> <h3 class="whitespace-none">Gene Expression Data Analysis</h3> <h3 class="subhead">Multiple tools are available in this website for analysis of gene expression data.</h3> <p style="line-height: 0.7em"> <a href="/PToolsWebsiteHowto.shtml#omicsDataAnalysis" class="learn-more-href" aria-label="Learn more about omics data analysis" >Learn More</a> </p> </div> <div class="slidePic"> <picture> <source srcset="/dispatchImages/webOmics.webp" type="image/webp">  <img class="pure-img" src="/dispatchImages/webOmics.png" alt="a portion of a cellular overview diagram, overlaid with a gene expression time series dataset. Detail popups are shown for three reactions in three different styles: a bar chart, a heatmap, and a line graph." width="581px" height="277px"> </picture> <p class="caption">Cellular Overview Omics Viewer image generated by Pathway Tools.</p> </div> </div> </div>   </div>  <div class="pure-u-xl-1-2 pure-u-lg-1-1 pure-u-md-1-1 pure-u-sm-1-1"> <div class="l-box-home"> <h1 class="splash-head"> HumanCyc: Encyclopedia of Human Genes and Metabolism </h1> <p> HumanCyc provides an encyclopedic reference on human metabolic pathways, the human genome, and human metabolites. </p> <p> HumanCyc is part of the larger BioCyc collection of thousands of Pathway/Genome Databases for sequenced genomes. Click the "Change Current Database" button above to explore the available databases. </p> <p> For more information on HumanCyc, see our article <a href="http://humancyc.org/publications.shtml#[HumanCyc04]"> "Computational prediction of human metabolic pathways from the complete human genome"</a> in <i>Genome Biology</i>. </p> <a style="height: 39px; vertical-align: top; padding-top: 0.75em;" href="http://biocyc.org/PToolsWebsiteHowto.shtml" class="pure-button primary-button">User Guide</a> <button class="pureFreeTrial pure-button" onclick="window.location.href='/new-account.shtml'"> Try Free </button> <button class="pureFreeTrial pure-button" onclick="window.location.href='https://share.hsforms.com/1GBRqdFaaSAKBjXodNpBKbA3ipje'" style="width: unset"> Request Free Classroom Use </button> </div> </div>  </div>   <div class="pure-g" style="align-items:baseline"> <div class="pure-u-lg-1-2 pure-u-sm-1-1" style="margin-bottom: 30px;"> <h2 class="content-majorhead" style="margin-block: 0;">What people are saying </h2> </div> <div class="pure-u-lg-1-2 pure-u-sm-1-1" style="margin-bottom: 15px;"> <a href="/biocyc-testimonials.shtml"> <span style="margin-left:20px;font-size: 19px"> See more BioCyc testimonials </span></a> </div> </div> <div class="testimonialCarousel"> <div> <div class="pureOrangeQuote"><p>"BsubCyc is a tool of the utmost value."</p><img class="attribution-img" src="/graphics2021/pennState.png" alt="Penn State"></img><p class="attribution"><i>Paul Babitzke<br>Prof. of Biochemistry<br>& Molecular Biology</i></p></div> </div> <div> <div class="pureBlueQuote"><p>"My lab uses these resources on a daily basis."</p><picture><img class="attribution-img" src="/graphics2021/UWisconsin.png" style="bottom: 45px; width: 92px; height: 31px;" alt="University of Wisconsin"></img></picture><p class="attribution"><i>Patricia Kiley,<br>Professor and Chair,<br>Dep't. of Biomolecular Chemistry</i></p></div> </div> <div> <div class="pureOrangeQuote"><p style="font-size: 21px">"We rely on BioCyc's Gene Pages and Overview Diagrams almost daily."</p><img class="attribution-img" src="/graphics2021/UMinnesota.png" style="height: 46px; bottom: 20px" alt="University of Minnesota"></img><p class="attribution"><i>Arkady Khodursky<br>Assoc. Prof. Biochemistry</i></p></div> </div> <div> <div class="pureBlueQuote"><p style="font-size: 16px; padding-top: 21px">"We use BioCyc and MetaCyc extensively to investigate the metabolic and regulatory processes of organisms we study."</p> <picture><img class="attribution-img" src="/graphics2021/pnnlFlatLogo.jpg" style="bottom:23px; width: 73px; height: 31px;" alt="Pacific Northwest National Lab"></img></picture><p class="attribution" style="bottom:-12px"><i>William Cannon, Team Lead<br>Computational Biology</i></p></div> </div> <div> <div class="pureOrangeQuote"><p>"BioCyc is the go-to resource of knowledge and tools for Ginkgo scientists."</p><img class="attribution-img" src="/graphics2021/GinkgoBioworks.png" style="bottom:15px;" alt="Ginkgo Bioworks"></img><p class="attribution"><i></i></p></div> </div> <div> <div class="pureBlueQuote"><p style="font-size: 20px; padding-top: 21px">"BioCyc is a tremendous resource for pathway analysis in metabolomics."</p><img class="attribution-img" src="/graphics2021/UGA.png" style="bottom:10px" alt="University of Georgia"></img><p class="attribution" style="bottom: 15px"><i>Art Edison, Dept of Genetics</i></p></div> </div> <div> <div class="pureOrangeQuote"><p style="font-size: 18px; margin-right: 25px; padding-top: 21px">"We make extensive use of the BioCyc full metabolic network diagram for omics data analysis."</p><img class="attribution-img" src="/graphics2021/GreatLakes.png" style="bottom: 5px" alt="Great Lakes Bioenergy"></img><p class="attribution" style="bottom:15px"><i>Timothy J. Donohue, Director</i></p></div> </div> <div> <div class="pureBlueQuote"><p style="font-size: 18px; padding-top: 21px">"I have not found another database that has a better interface than BioCyc."</p><img class="attribution-img" src="/graphics2021/UMich.png" style="bottom:25px" alt="University of Michigan"></img><p class="attribution"><i>Gary B. Huffnagle, Professor<br>Microbiology and Immunology</i></p></div> </div> </div>   <div class="pure-g" style="background: #FAFAFA;"> <div class="pure-u-xl-1-1 pure-u-sm-1-1" style="padding-left: 20px"> <h2 class="content-majorhead">Learning Library</h2> </div> <div class="pure-u-xl-1-2 pure-u-lg-1-1 pure-u-sm-1-1" style="max-width:fit-content; margin-left: auto; margin-right:auto;"> <div class="l-box-home pure-hidden-phone" > <div style="width: 560px; height: 315px; margin-left: -40px"> <lite-youtube videoid="2eCrAUF0-jg" videotitle="Quick Introduction to BioCyc">  </div> </div> </div> <div class="pure-u-xl-1-2 pure-u-lg-1-1 pure-u-sm-1-1" style="max-width:fit-content; margin-left: auto; margin-right:auto;"> <div class="l-box" style="padding: 0";> <h3 style="margin-top: 3px; margin-bottom: 12px">Tutorial Videos</h3> <div class="accordion" id="AccordionWebinar"> <details> <summary>Tutorial #1: Introduction to BioCyc</summary> <div> To download or view, just click on one of the links following each segment's name. <ul> <li><a href="https://youtu.be/2eCrAUF0-jg">Quick Introduction to BioCyc (4:30) </a> <li><a href="https://youtu.be/vPbJUyyMrbo">Searching in BioCyc (17:00)</a> <li><a href="https://youtu.be/y13lfIQRd3Y">Genes (15:00)</a> <li><a href="https://www.youtube.com/watch?v=VQIYRgMXlJc">Genome Browser (11:45) </a> <li><a href="http://youtu.be/vmanLbAOlFw">Pathways (13:19) </a> <li><a href="http://youtu.be/A0POxCr7I_E">Reactions (3:37) </a> <li><a href="http://youtu.be/FjMmDLpDZb4">Compounds (6:42) </a> </ul> </div> </details> <details> <summary>Tutorial #2: Introduction to SmartTables </summary> <div> The following Tutorial will guide you through SmartTables, which enable you to create, upload, share, and analyze sets of genes, metabolites, pathways, and sequence sites. The Tutorial is broken up into parts, ranging from basic operations to more advanced uses such as gene expression analysis and metabolomics. To download or view, click one of the links below. <ul> <li><a href="https://youtu.be/lNfHYqSAkwE">SmartTables Overview (4:30)</a> <li><a href=" https://youtu.be/4nQlYQJl278">SmartTables Basics (12:43)</a> <li><a href="https://youtu.be/JsnPSgr01-c">SmartTables Transformations (8:08) </a> <li><a href=" https://youtu.be/Kc7RIDerRa8">SmartTables Import and Export (9:00) </a> <li><a href="https://youtu.be/u4KN0iFHl9o">SmartTables Gene Expression Analysis (7:40)</a> <li><a href="https://youtu.be/ZtC6-X4UrcA">Metabolomics Analysis with SmartTables (6:45) </a> </ul> </div> </details> <details> <summary>Tutorial #3: Zoomable Metabolic Map, Comparative Tools, Regulatory Network</summary> <div> This tutorial introduces users to many of the advanced tools available on the BioCyc.org website for navigating cellular networks, analyzing large-scale datasets, and comparing organisms. <ul> <li><a href="https://youtu.be/D1auFR-YtyA">The Cellular Overview: Navigating metabolic networks (17:15) </a> <li><a href="https://www.youtube.com/watch?v=edlc_pwgszw">Comparative Genomics (21:06) </a> <li><a href="https://www.youtube.com/watch?v=_25kvmBC9wE">Ortholog Viewing (10:02) </a> <li><a href="https://youtu.be/AtXsbRwBFvo">The Regulatory Overview -- exploring transcriptional regulatory networks (15:21) </a> </ul> </div> </details> <details> <summary>Tutorial #4: Omics Data Analysis</summary> <div> This tutorial will show you how to use BioCyc's tools for omics data analysis, including the cellular omics viewer, the omics dashboard, and other tools. <ul> <li><a href="https://youtu.be/k6ZUBjHDH_0">Transcriptomics Analysis Tools [brief tour (2:40) </a></li> <li> <a href="https://www.youtube.com/watch?v=gDiNdp3hnWg"> Metabolomics Analysis Tools (3:26) <a href="https://www.youtube.com/watch?v=RVkmpDTdcIU&t=2s">[click here for a detailed tutorial]</a> </li> <li><a href="https://youtu.be/lfea1lKsiWk">Omics Dashboard (16:35)</a> </li> <li> <a href="https://youtu.be/eDMcTDAMVXU">Omics Dashboard Part (24:29) </a> </li> </ul> </div> </details> <details> <summary>Tutorial #5: Pathway Collages</summary> <div> Pathway collages are multi-pathway diagrams that you can customize by, for example, overlaying omics data, altering the relative positions of pathways, and modifying connections among pathways. Learn how to generate, customize and export high-quality pathway-collage diagrams showing collections of user-specified pathways. <ul> <li> <a href="https://www.youtube.com/watch?v=WW0nVpXAusg&feature=youtu.be">Pathway Collages (22:39)</a> </li> </ul> </div> </details> <details> <summary>Tutorial #6: Creating a Pathway/Genome Database</summary> <div> Learn the entire process of building a BioCyc-like Pathway/Genome Database (PGDB) for an organism with a sequenced and annotated genome. Build a PGDB for your own lab or for the whole scientific community. <ul> <li><a href="https://youtu.be/8GTifTlmnZA">Part 1A: Introduction to Database Building and Pathologic (14:04) </a></li> <li> <a href="https://youtu.be/bn1DHXBpVQk">Part 1B: Building a Database: Detailed Pathologic Example (23:53) </a></li> <li><a href="https://youtu.be/va6UY6OdW1k">Part 2A: General Editing Strategies (8:00) </a> <li> <a href="https://youtu.be/eeMVaP9H7-k">Part 2B: Creating and Editing Reactions and Compounds (17:32)</a> <li> <a href="https://youtu.be/msYOJ3lwzck">Part 2C: Updating Proteins, Citations, GO Terms, and Enzymatic Reactions (26:10) </a> <li><a href="https://youtu.be/06kXAwJUUj0">Part 2D: Making and Editing Pathways (9:42) </a> </ul> </div> </details> <details> <summary>Tutorial #7: Using the Structured Advanced Query Page</summary> <div> An introduction to the Structured Advanced Query Page, which allows complex queries and queries across one or more databases in the BioCyc collection. You'll learn about:The basic steps of setting up an advanced query; Four examples of increasingly complex queries, including how to query across multiple databases; Where to learn more about the structure of BioCyc databases. <ul> <li><a href="https://youtu.be/3fT1T6nu3C4">Structured Advanced Query Page Quick Introduction (6:27) </a> <li> <a href="https://youtu.be/4RSexCHLbI8">Structured Advanced Query Page Full Tutorial (42:15) </a> </ul> </div> </details> </div> </div> </div> </div>      </div>  <script type="text/javascript" src="//cdn.jsdelivr.net/npm/@accessible360/accessible-slick@1.0.1/slick/slick.min.js"></script> <script type="text/javascript" src="/promoSlideShow.js"></script>  </div>                <script TYPE="text/javascript" SRC="/combined/combined-1.js?v=28.5"></script>   <script type="text/javascript" src="/get-organisms-fast.js"></script> <script type="text/javascript" src="/get-user-data.js"></script>  <script type="text/javascript" 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Organism Databases</b></div> <div class="bd" id="multiorgSelectorBody"> <form id="multiorgSelectorForm" action='/'> <div id='legend' style="max-width:900px"></div> <div id='multiorg3columns'> <div> <h3>Select One or More Databases: <span id="multiorgMaxLabel"></span></h3> <div id="multiorgSelectorTabs" class="orgSelectorTabs" style='min-width:504px'> <ul> <li class="selected"><a href="#multiorgNameTab">By Name</a></li> <li><a href="#multiorgTaxTab">By Taxonomy</a></li> <li><a href="#multiorgMetadataTab">By Organism Properties</a></li> <li><a href="#multiorgSavedTab">My Lists</a></li> </ul> <div id="multiorgNameTab" class='multiorgselectorTab'> <div class='orgselectorByNameContents'> <div id="multiorgRightcontent" class='nameACColumn'> <label id="multiorgFilterOptions" style="display:block;text-align:right;font-size:smaller"> Organism Filter: <select id="multiorgFilter" onChange='updateMultiOrgFilter()'> </select> </label> <div id="multiorgselectorAutoComplete"> <input id="multiorgInput" type="text" aria-label="Start typing a genus, species and/or strain name" placeholder="Start typing a genus, species and/or strain name" spellcheck=false aria-autocomplete="list" > <div id="multiorgContainer" style="font-style:italic"></div> </div> <div id="multiorgnum"></div> </div> <div class="alphabetFilter"> <div class="screen-reader-only"> <h3>Filter organisms by first letter</h3> </div> <a href="javascript:alphabetClick('a')">A</a><br> <a href="javascript:alphabetClick('b')">B</a><br> <a href="javascript:alphabetClick('c')">C</a><br> <a href="javascript:alphabetClick('d')">D</a><br> <a href="javascript:alphabetClick('e')">E</a><br> <a href="javascript:alphabetClick('f')">F</a><br> <a href="javascript:alphabetClick('g')">G</a><br> <a href="javascript:alphabetClick('h')">H</a><br> <a href="javascript:alphabetClick('i')">I</a><br> <a href="javascript:alphabetClick('j')">J</a><br> <a href="javascript:alphabetClick('k')">K</a><br> <a href="javascript:alphabetClick('l')">L</a><br> <a href="javascript:alphabetClick('m')">M</a><br> <a href="javascript:alphabetClick('n')">N</a><br> <a href="javascript:alphabetClick('o')">O</a><br> <a href="javascript:alphabetClick('p')">P</a><br> <a href="javascript:alphabetClick('q')">Q</a><br> <a href="javascript:alphabetClick('r')">R</a><br> <a href="javascript:alphabetClick('s')">S</a><br> <a href="javascript:alphabetClick('t')">T</a><br> <a href="javascript:alphabetClick('u')">U</a><br> <a href="javascript:alphabetClick('v')">V</a><br> <a href="javascript:alphabetClick('w')">W</a><br> <a href="javascript:alphabetClick('x')">X</a><br> <a href="javascript:alphabetClick('y')">Y</a><br> <a href="javascript:alphabetClick('z')">Z</a><br> </div> </div> </div> <div id="multiorgTaxTab" class='multiorgselectorTab'> <label id="multiorgTaxAutoComplete"> <span style="padding-right:5px">Search for taxon in taxonomy tree: </span> <input id="multiorgTaxName" type="text" style="width:360px" /> <div id="multiorgTaxContainer"></div> </label> <div id="multiorgTaxTreeContainer" style="min-width:489px;overflow-y:auto;margin-top:12px"> <div id="multiorgSelectorTaxTree" class="ygtv-checkbox"></div> </div> </div> <div id="multiorgMetadataTab" style="min-width:489px;overflow-y:auto" class='multiorgselectorTab' > Find organism databases according to: <ul style="line-height:118%;margin-top:4px"> <li>Organism characteristics, e.g. pathogenicity = human <li>Collection metadata, e.g. human microbiome body site = blood <li>Database properties, e.g. # (number) of Genes < 500 </ul> <div id="mclause0" class="flexRowWrap"> <select id="mmdSlot0" onChange='updateMetadataSlot(0, "m")' aria-label='Property for constraint 1'> <option value=false selected>Select Property</option> </select> <select id="mmdConstraint0" onChange='updateMetadataSlot(0, "m")' aria-label='Operator for constraint 1'> <option value="c" selected>is</option> <option value="nc">is not</option> <option value="a">has any value</option> <option value="n">has no value</option> </select> <div id="mkeywordInput0" style="display:none" class="flexRow"> <select id="mmdKeywordOp0" onchange="updateForOp(0, 'mmdKeywordOp0', 'mmdSubstringAC0', 'm')" aria-label='Operator for constraint 1'> <option value="enum" selected>Exact Match</option> <option value="substr">Substring Match</option> </select> <div class = "mdSubstringInput" id="mmdSubstringAC0"> <input id="mmdKeyword0" type="text" aria-label='Value for constraint 1'> <div id="mmdKWContainer0"></div> </div> </div> <div id="mnumericInput0" style="display:none" class="flexRow"> <select id="mmdNumOp0" onchange="updateForOp(0, 'mmdNumOp0', 'mmdNum0', 'm')" aria-label='Numeric operator for constraint 1'> <option value="e" selected>= (approx.)</option> <option value="lt"><</option> <option value="lte">≤</option> <option value="gt">></option> <option value="gte">≥</option> <option value="enum">Select Values</option> </select> <input id="mmdNum0" type="text" aria-label='Value for constraint 1'> </div> <div id="mmdEnumContainer0" style="display:none"> <select id="mmdEnum0" multiple aria-label='Value for constraint 1'> </select> </div> </div> <div id="mclause1" style="display:none"> <select id="mconnector1" aria-label='Connector for constraint 2'> <option value='AND' selected>AND</option> <option value='OR'>OR</option> </select> <input id="mmdDelete1" type="button" value ="Remove Constraint" onclick='mdRemoveClause(1, "m")' aria-label='Remove Constraint 2'> <br> <div class="flexRowWrap"> <select id="mmdSlot1" onChange='updateMetadataSlot(1, "m")' aria-label='Property for constraint 2'> <option value=false selected>Select Property</option> </select> <select id="mmdConstraint1" onChange='updateMetadataSlot(1, "m")' aria-label='Operator for constraint 2'> <option value="c" selected>is</option> <option value="nc">is not</option> <option value="a">has any value</option> <option value="n">has no value</option> </select> <div id="mkeywordInput1" style="display:none" class="flexRow"> <select id="mmdKeywordOp1" onchange="updateForOp(1, 'mmdKeywordOp1', 'mmdSubstringAC1', 'm')" aria-label='Operator for constraint 2'> <option value="enum" selected>Exact Match</option> <option value="substr">Substring Match</option> </select> <div class = "mdSubstringInput" id="mmdSubstringAC1"> <input id="mmdKeyword1" type="text" aria-label='Value for constraint 2'> <div id="mmdKWContainer1"></div> </div> </div> <div id="mnumericInput1" style="display:none" class="flexRow"> <select id="mmdNumOp1" onchange="updateForOp(1, 'mmdNumOp1', 'mmdNum1', 'm')" aria-label='Numeric operator for constraint 2'> <option value="e" selected>= (approx.)</option> <option value="lt"><</option> <option value="lte">≤</option> <option value="gt">></option> <option value="gte">≥</option> <option value="enum">Select Values</option> </select> <input id="mmdNum1" type="text" aria-label='Value for constraint 2'> </div> <div id="mmdEnumContainer1" style="display:none"> <select id="mmdEnum1" multiple aria-label='Value for constraint 2'> </select> </div> </div> </div> <div id="mclause2" style="display:none"> <select id="mconnector2" aria-label='Connector for constraint 3'> <option value='and' selected>AND</option> <option value='or'>OR</option> </select> <input id="mmdDelete2" type="button" value="Remove Constraint" onclick='mdRemoveClause(2, "m")' aria-label='Remove Constraint 3'> <br> <div class="flexRowWrap"> <select id="mmdSlot2" onChange='updateMetadataSlot(2, "m")' aria-label='Property for constraint 3'> <option value=false selected>Select Property</option> </select> <select id="mmdConstraint2" onChange='updateMetadataSlot(2, "m")' aria-label='Operator for constraint 3'> <option value="c" selected>is</option> <option value="nc">is not</option> <option value="a">has any value</option> <option value="n">has no value</option> </select> <div id="mkeywordInput2" style="display:none" class="flexRow"> <select id="mmdKeywordOp2" onchange="updateForOp(2, 'mmdKeywordOp2', 'mmdSubstringAC', 'm')" aria-label='Operator for constraint 3'> <option value="enum" selected>Exact Match</option> <option value="substr">Substring Match</option> </select> <div class = "mdSubstringInput" id="mmdSubstringAC2"> <input id="mmdKeyword2" type="text" aria-label='Value for constraint 3'> <div id="mmdKWContainer2"></div> </div> </div> <div id="mnumericInput2" style="display:none" class="flexRow"> <select id="mmdNumOp2" onchange="updateForOp(2, 'mmdNumOp2', 'mmdNum2', 'm')" aria-label='Numeric operator for constraint 3'> <option value="e" selected>= (approx.)</option> <option value="lt"><</option> <option value="lte">≤</option> <option value="gt">></option> <option value="gte">≥</option> <option value="enum">Select Values</option> </select> <input id="mmdNum2" type="text" aria-label='Value for constraint 3'> </div> <div id="mmdEnumContainer2" style="display:none"> <select id="mmdEnum2" multiple aria-label='Value for constraint 3'> </select> </div> </div> </div> <div id="mclause3" style="display:none"> <select id="mconnector3" aria-label='Connector for constraint 4'> <option value='and' selected>AND</option> <option value='or'>OR</option> </select> <input id="mmdDelete3" type="button" value="Remove Constraint" onclick='mdRemoveClause(3, "m")' aria-label='Remove Constraint 4'> <br> <div class="flexRowWrap"> <select id="mmdSlot3" onChange='updateMetadataSlot(3, "m")' aria-label='Property for constraint 4'> <option value=false selected>Select Property</option> </select> <select id="mmdConstraint3" onChange='updateMetadataSlot(3, "m")' aria-label='Operator for constraint 4'> <option value="c" selected>is</option> <option value="nc">is not</option> <option value="a">has any value</option> <option value="n">has no value</option> </select> <div id="mkeywordInput3" style="display:none" class="flexRow"> <select id="mmdKeywordOp3" onchange="updateForOp(3, 'mmdKeywordOp3', 'mmdSubstringAC3', 'm')" aria-label='Operator for constraint 4'> <option value="enum" selected>Exact Match</option> <option value="substr">Substring Match</option> </select> <div class = "mdSubstringInput" id="mmdSubstringAC3"> <input id="mmdKeyword3" type="text" aria-label='Value for constraint 4'> <div id="mmdKWContainer3"></div> </div> </div> <div id="mnumericInput3" style="display:none" class="flexRow"> <select id="mmdNumOp3" onchange="updateForOp(3, 'mmdNumOp3', 'mmdNum3', 'm')" aria-label='Numeric operator for constraint 4'> <option value="e" selected>= (approx.)</option> <option value="lt"><</option> <option value="lte">≤</option> <option value="gt">></option> <option value="gte">≥</option> <option value="enum">Select Values</option> </select> <input id="mmdNum3" type="text" aria-label='Value for constraint 4'> </div> <div id="mmdEnumContainer3" style="display:none"> <select id="mmdEnum3" multiple aria-label='Value for constraint 4'> </select> </div> </div> </div> <div id="mclause4" style="display:none"> <select id="mconnector4" aria-label='Connector for constraint 5'> <option value='and' selected>AND</option> <option value='or'>OR</option> </select> <input id="mmdDelete4" type="button" value = "Remove Constraint" onclick='mdRemoveClause(4, "m")' aria-label='Remove Constraint 5'> <br> <div class="flexRowWrap"> <select id="mmdSlot4" onChange='updateMetadataSlot(4, "m")' aria-label='Property for constraint 5'> <option value=false selected>Select Property</option> </select> <select id="mmdConstraint4" onChange='updateMetadataSlot(4, "m")' aria-label='Operator for constraint 5'> <option value="c" selected>is</option> <option value="nc">is not</option> <option value="a">has any value</option> <option value="n">has no value</option> </select> <div id="mkeywordInput4" style="display:none" class="flexRow"> <select id="mmdKeywordOp4" onchange="updateForOp(4, 'mmdKeywordOp4', 'mmdSubstringAC4', 'm')" aria-label='Operator for constraint 5'> <option value="enum" selected>Exact Match</option> <option value="substr">Substring Match</option> </select> <div class = "mdSubstringInput" id="mmdSubstringAC4"> <input id="mmdKeyword4" type="text" aria-label='Value for constraint 5'> <div id="mmdKWContainer4"></div> </div> </div> <div id="mnumericInput4" style="display:none"> <select id="mmdNumOp4" onchange="updateForOp(4, 'mmdNumOp4', 'mmdNum4', 'm')" aria-label='Numeric operator for constraint 5'> <option value="e" selected>= (approx.)</option> <option value="lt"><</option> <option value="lte">≤</option> <option value="gt">></option> <option value="gte">≥</option> <option value="enum">Select Values</option> </select> <input id="mmdNum4" type="text" aria-label='Value for constraint 5'> </div> <div id="mmdEnumContainer4" style="display:none"> <select id="mmdEnum4" multiple aria-label='Value for constraint 5'> </select> </div> </div> </div> <div id="mclause5" style="display:none"> <select id="mconnector5" aria-label='Connector for constraint 6'> <option value='and' selected>AND</option> <option value='or'>OR</option> </select> <input id="mmdDelete5" type="button" value="Remove Constraint" onclick='mdRemoveClause(5, "m")' aria-label='Remove Constraint 6'> <br> <div class="flexRowWrap"> <select id="mmdSlot5" onChange='updateMetadataSlot(5, "m")' aria-label='Property for constraint 6'> <option value=false selected>Select Property</option> </select> <select id="mmdConstraint5" onChange='updateMetadataSlot(5, "m")' aria-label='Operator for constraint 6'> <option value="c" selected>is</option> <option value="nc">is not</option> <option value="a">has any value</option> <option value="n">has no value</option> </select> <div id="mkeywordInput5" style="display:none" class="flexRow"> <select id="mmdKeywordOp5" onchange="updateForOp(5, 'mmdKeywordOp5', 'mmdSubstringAC5', 'm')" aria-label='Operator for constraint 6'> <option value="enum" selected>Exact Match</option> <option value="substr">Substring Match</option> </select> <div class = "mdSubstringInput" id="mmdSubstringAC5"> <input id="mmdKeyword5" type="text" aria-label='Value for constraint 6'> <div id="mmdKWContainer5"></div> </div> </div> <div id="mnumericInput5" style="display:none" class="flexRow"> <select id="mmdNumOp5" onchange="updateForOp(5, 'mmdNumOp5', 'mmdNum5', 'm')" aria-label='Numeric operator for constraint 6'> <option value="e" selected>= (approx.)</option> <option value="lt"><</option> <option value="lte">≤</option> <option value="gt">></option> <option value="gte">≥</option> <option value="enum">Select Values</option> </select> <input id="mmdNum5" type="text" aria-label='Value for constraint 6'> </div> <div id="mmdEnumContainer5" style="display:none"> <select id="mmdEnum5" multiple aria-label='Value for constraint 6'> </select> </div> </div> </div> <br> <div class="flexRow"> <input id="maddClause" type="button" value = "Add Constraint" onclick='mdAddClause("m")' style="display:none"> <input id="mmdSearch" type="button" value = "Find Organisms" onclick = 'processMdQuery(true, "m")'> </div> <div id="mmdResults" class='yui3-skin-sam'></div> </div> <div id="multiorgSavedTab" class='multiorgselectorTab' style="overflow-y:auto"> <div style="padding-bottom:20px"> <span>Database lists include both predefined lists and lists that are saved as SmartTables that you can edit from your <a href="/smarttables" target="new.window">My SmartTables</a> page. To add all organisms from a saved list, check the box next to the list name and then click the "Add" button. </span> </div> <div id="multiorgSavedTree" class="ygtv-checkbox"></div> <div class="requiresLogin" style="padding-top:50px"> <span class="requiresNoSavedOrglist requiresLogin"> You have no saved database lists </span> </div> <div class="requiresNotLoggedIn" style="padding-top:50px"> Log in and reload this page to access your saved database lists. </div> </div> </div> <div id="tierKey" style="padding-top:3px"> <span class="tier1">Tier 1</span> and <span class="tier2">Tier 2</span> databases are displayed with orange and blue backgrounds, respectively. </div> </div> <div class='buttons flexCol' style="gap:4px;margin:3px;"> <div id="multiorgSelectAllRow"> <input type="button" id="multiorgSelectAllBtn" class="disableWhenAllSelected" value="Select All" onclick="multiorgSelectAll()"> </div> <input type="button" id="multiorgAddToList" class="disableWhenAllSelected" value="Add →" onclick="addNewSelections()"> <input type="button" id="multiorgDeleteFromList" class="disableWhenAllSelected" value="Remove ←" onclick="deleteMultiorgOptions(false)"> <input type="button" id="multiorgClearAll" value="Clear All" onclick="deleteMultiorgOptions(true)"> <input type="button" id="moveup" value="Up ↑" onclick="moveUpOption()"> <input type="button" id="movedown" value="Down ↓" onclick="moveDownOption()"> </div> <div> <label for="multiorgSelection"><h3>Current Selection</h3></label> <span id="multiNumSelected">0</span> databases or taxa currently selected. <p> <div id='multiorgSelectionDiv'> <select multiple id="multiorgSelection"> </select> </div> <div class="requiresLogin" id="rememberAsST"> <fieldset style="border:none;padding:0"> <legend style="padding-top:3px"> Remember Selection as SmartTable:</legend> <label> <input type="radio" name="stSave" value="new" checked> Create New </label> <label> <input type="radio" name="stSave" value="old"> Update Existing </label> <div style="padding-top:3px"> <input type="text" id="orglistname" style="width:200px" placeholder="Enter SmartTable Name"> <select id="savedOrglistUpdate" class="savedOrglistSelectEl" aria-label="Select an organism SmartTable to update" style="display:none"> </select> <input type="button" value="Save" title="Clicking this button will save or update the specified organism SmartTable to refer to the currently selected databases. It will not close this dialog or submit your choices. If no databases are currently selected, clicking this button will cause the named SmartTable to be deleted. SmartTables saved here can be accessed from the My Lists tab."> </div> </fieldset> </div> <div class="requiresNotLoggedIn" style="padding-top:3px"> Note: if you create a user account and log in, you can save your database lists for next time. </div> </div> </div> </form> </div> </div> <script type="text/javascript"> multiorg_maxOrgs = 70 </script>  <script type="text/javascript"> if (forceOrgID && forceOrgID != "DEFAULT") setOrganism(forceOrgID); </script> <script src="https://unpkg.com/@popperjs/core@2"></script> <script src="https://unpkg.com/tippy.js@6"></script> <script> /* following relates to tooltips for template-top-menubar */ var subTipContent; subTipContent = "You are not connected to a paid subscription, which limits your access to BioCyc. The EcoCyc database is free."; var accelTipContent = "Create a free account and receive one month of free access to BioCyc. Even if your institution already subscribes to BioCyc, you still need to create an account for ongoing access."; if (subTipContent) { tippy('#subscribe', { content: subTipContent, theme: 'biocyc', placement: 'bottom', plugins: [hideOnEsc] }); } tippy('#account', { content: accelTipContent, theme: 'biocyc', placement: 'bottom', plugins: [hideOnEsc] }); /* following relates to tooltip for MetaCyc */ tippy('#metacycRef', { theme: 'biocyc', content: "MetaCyc is a curated database of metabolic enzymes and pathways from all domains of life.", placement: 'right', plugins: [hideOnEsc] }); </script>   </body> </html>

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HumanCyc: Encyclopedia of Human Genes and Metabolism