CINXE.COM

<!DOCTYPE html> <html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-sticky-header-enabled vector-toc-available" lang="en" dir="ltr"> <head> <meta charset="UTF-8"> <title>Interleukin-15 receptor - Wikipedia</title> <script>(function(){var className="client-js vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-sticky-header-enabled vector-toc-available";var cookie=document.cookie.match(/(?:^|; )enwikimwclientpreferences=([^;]+)/);if(cookie){cookie[1].split('%2C').forEach(function(pref){className=className.replace(new RegExp('(^| )'+pref.replace(/-clientpref-\w+$|[^\w-]+/g,'')+'-clientpref-\\w+( |$)'),'$1'+pref+'$2');});}document.documentElement.className=className;}());RLCONF={"wgBreakFrames":false,"wgSeparatorTransformTable":["",""],"wgDigitTransformTable":["",""],"wgDefaultDateFormat":"dmy", "wgMonthNames":["","January","February","March","April","May","June","July","August","September","October","November","December"],"wgRequestId":"142f2828-1578-4e80-bd91-5c08b9178542","wgCanonicalNamespace":"","wgCanonicalSpecialPageName":false,"wgNamespaceNumber":0,"wgPageName":"Interleukin-15_receptor","wgTitle":"Interleukin-15 receptor","wgCurRevisionId":1221322308,"wgRevisionId":1221322308,"wgArticleId":15667919,"wgIsArticle":true,"wgIsRedirect":false,"wgAction":"view","wgUserName":null,"wgUserGroups":["*"],"wgCategories":["CS1 maint: date and year","Articles with short description","Short description is different from Wikidata","Pages using infobox protein with unknown parameters","Genes on human chromosome 10","Genes on human chromosome 22","Genes on human chromosome X","Type I cytokine receptors"],"wgPageViewLanguage":"en","wgPageContentLanguage":"en","wgPageContentModel":"wikitext","wgRelevantPageName":"Interleukin-15_receptor","wgRelevantArticleId":15667919, "wgIsProbablyEditable":true,"wgRelevantPageIsProbablyEditable":true,"wgRestrictionEdit":[],"wgRestrictionMove":[],"wgNoticeProject":"wikipedia","wgCiteReferencePreviewsActive":false,"wgFlaggedRevsParams":{"tags":{"status":{"levels":1}}},"wgMediaViewerOnClick":true,"wgMediaViewerEnabledByDefault":true,"wgPopupsFlags":0,"wgVisualEditor":{"pageLanguageCode":"en","pageLanguageDir":"ltr","pageVariantFallbacks":"en"},"wgMFDisplayWikibaseDescriptions":{"search":true,"watchlist":true,"tagline":false,"nearby":true},"wgWMESchemaEditAttemptStepOversample":false,"wgWMEPageLength":7000,"wgEditSubmitButtonLabelPublish":true,"wgULSPosition":"interlanguage","wgULSisCompactLinksEnabled":false,"wgVector2022LanguageInHeader":true,"wgULSisLanguageSelectorEmpty":false,"wgWikibaseItemId":"Q27312158","wgCheckUserClientHintsHeadersJsApi":["brands","architecture","bitness","fullVersionList","mobile","model","platform","platformVersion"],"GEHomepageSuggestedEditsEnableTopics":true,"wgGETopicsMatchModeEnabled": false,"wgGEStructuredTaskRejectionReasonTextInputEnabled":false,"wgGELevelingUpEnabledForUser":false};RLSTATE={"ext.globalCssJs.user.styles":"ready","site.styles":"ready","user.styles":"ready","ext.globalCssJs.user":"ready","user":"ready","user.options":"loading","ext.cite.styles":"ready","skins.vector.search.codex.styles":"ready","skins.vector.styles":"ready","skins.vector.icons":"ready","jquery.makeCollapsible.styles":"ready","ext.wikimediamessages.styles":"ready","ext.visualEditor.desktopArticleTarget.noscript":"ready","ext.uls.interlanguage":"ready","wikibase.client.init":"ready","ext.wikimediaBadges":"ready"};RLPAGEMODULES=["ext.cite.ux-enhancements","site","mediawiki.page.ready","jquery.makeCollapsible","mediawiki.toc","skins.vector.js","ext.centralNotice.geoIP","ext.centralNotice.startUp","ext.gadget.ReferenceTooltips","ext.gadget.switcher","ext.urlShortener.toolbar","ext.centralauth.centralautologin","mmv.bootstrap","ext.popups","ext.visualEditor.desktopArticleTarget.init", "ext.visualEditor.targetLoader","ext.echo.centralauth","ext.eventLogging","ext.wikimediaEvents","ext.navigationTiming","ext.uls.interface","ext.cx.eventlogging.campaigns","ext.cx.uls.quick.actions","wikibase.client.vector-2022","ext.checkUser.clientHints","ext.growthExperiments.SuggestedEditSession"];</script> <script>(RLQ=window.RLQ||[]).push(function(){mw.loader.impl(function(){return["user.options@12s5i",function($,jQuery,require,module){mw.user.tokens.set({"patrolToken":"+\\","watchToken":"+\\","csrfToken":"+\\"}); }];});});</script> <link rel="stylesheet" href="/w/load.php?lang=en&modules=ext.cite.styles%7Cext.uls.interlanguage%7Cext.visualEditor.desktopArticleTarget.noscript%7Cext.wikimediaBadges%7Cext.wikimediamessages.styles%7Cjquery.makeCollapsible.styles%7Cskins.vector.icons%2Cstyles%7Cskins.vector.search.codex.styles%7Cwikibase.client.init&only=styles&skin=vector-2022"> <script async="" src="/w/load.php?lang=en&modules=startup&only=scripts&raw=1&skin=vector-2022"></script> <meta name="ResourceLoaderDynamicStyles" content=""> <link rel="stylesheet" href="/w/load.php?lang=en&modules=site.styles&only=styles&skin=vector-2022"> <meta name="generator" content="MediaWiki 1.44.0-wmf.17"> <meta name="referrer" content="origin"> <meta name="referrer" content="origin-when-cross-origin"> <meta name="robots" content="max-image-preview:standard"> <meta name="format-detection" content="telephone=no"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/a/a1/Protein_IL15RA_PDB_2ers.png"> <meta property="og:image:width" content="1200"> <meta property="og:image:height" content="730"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Protein_IL15RA_PDB_2ers.png/800px-Protein_IL15RA_PDB_2ers.png"> <meta property="og:image:width" content="800"> <meta property="og:image:height" content="487"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Protein_IL15RA_PDB_2ers.png/640px-Protein_IL15RA_PDB_2ers.png"> <meta property="og:image:width" content="640"> <meta property="og:image:height" content="390"> <meta name="viewport" content="width=1120"> <meta property="og:title" content="Interleukin-15 receptor - Wikipedia"> <meta property="og:type" content="website"> <link rel="preconnect" href="//upload.wikimedia.org"> <link rel="alternate" media="only screen and (max-width: 640px)" href="//en.m.wikipedia.org/wiki/Interleukin-15_receptor"> <link rel="alternate" type="application/x-wiki" title="Edit this page" href="/w/index.php?title=Interleukin-15_receptor&action=edit"> <link rel="apple-touch-icon" href="/static/apple-touch/wikipedia.png"> <link rel="icon" href="/static/favicon/wikipedia.ico"> <link rel="search" type="application/opensearchdescription+xml" href="/w/rest.php/v1/search" title="Wikipedia (en)"> <link rel="EditURI" type="application/rsd+xml" href="//en.wikipedia.org/w/api.php?action=rsd"> <link rel="canonical" href="https://en.wikipedia.org/wiki/Interleukin-15_receptor"> <link rel="license" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en"> <link rel="alternate" type="application/atom+xml" title="Wikipedia Atom feed" href="/w/index.php?title=Special:RecentChanges&feed=atom"> <link rel="dns-prefetch" href="//meta.wikimedia.org" /> <link rel="dns-prefetch" href="login.wikimedia.org"> </head> <body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject mw-editable page-Interleukin-15_receptor rootpage-Interleukin-15_receptor skin-vector-2022 action-view"><a class="mw-jump-link" href="#bodyContent">Jump to content</a> <div class="vector-header-container"> <header class="vector-header mw-header"> <div class="vector-header-start"> <nav class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-dropdown" class="vector-dropdown vector-main-menu-dropdown vector-button-flush-left vector-button-flush-right" title="Main menu" > <input type="checkbox" id="vector-main-menu-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-main-menu-dropdown" class="vector-dropdown-checkbox " aria-label="Main menu" > <label id="vector-main-menu-dropdown-label" for="vector-main-menu-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-menu mw-ui-icon-wikimedia-menu"></span> <span class="vector-dropdown-label-text">Main menu</span> </label> <div class="vector-dropdown-content"> <div id="vector-main-menu-unpinned-container" class="vector-unpinned-container"> <div id="vector-main-menu" class="vector-main-menu vector-pinnable-element"> <div class="vector-pinnable-header vector-main-menu-pinnable-header vector-pinnable-header-unpinned" data-feature-name="main-menu-pinned" data-pinnable-element-id="vector-main-menu" data-pinned-container-id="vector-main-menu-pinned-container" data-unpinned-container-id="vector-main-menu-unpinned-container" > <div class="vector-pinnable-header-label">Main menu</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-main-menu.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-main-menu.unpin">hide</button> </div> <div id="p-navigation" class="vector-menu mw-portlet mw-portlet-navigation" > <div class="vector-menu-heading"> Navigation </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-mainpage-description" class="mw-list-item"><a href="/wiki/Main_Page" title="Visit the main page [z]" accesskey="z"><span>Main page</span></a></li><li id="n-contents" class="mw-list-item"><a href="/wiki/Wikipedia:Contents" title="Guides to browsing Wikipedia"><span>Contents</span></a></li><li id="n-currentevents" class="mw-list-item"><a href="/wiki/Portal:Current_events" title="Articles related to current events"><span>Current events</span></a></li><li id="n-randompage" class="mw-list-item"><a href="/wiki/Special:Random" title="Visit a randomly selected article [x]" accesskey="x"><span>Random article</span></a></li><li id="n-aboutsite" class="mw-list-item"><a href="/wiki/Wikipedia:About" title="Learn about Wikipedia and how it works"><span>About Wikipedia</span></a></li><li id="n-contactpage" class="mw-list-item"><a href="//en.wikipedia.org/wiki/Wikipedia:Contact_us" title="How to contact Wikipedia"><span>Contact us</span></a></li> </ul> </div> </div> <div id="p-interaction" class="vector-menu mw-portlet mw-portlet-interaction" > <div class="vector-menu-heading"> Contribute </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-help" class="mw-list-item"><a href="/wiki/Help:Contents" title="Guidance on how to use and edit Wikipedia"><span>Help</span></a></li><li id="n-introduction" class="mw-list-item"><a href="/wiki/Help:Introduction" title="Learn how to edit Wikipedia"><span>Learn to edit</span></a></li><li id="n-portal" class="mw-list-item"><a href="/wiki/Wikipedia:Community_portal" title="The hub for editors"><span>Community portal</span></a></li><li id="n-recentchanges" class="mw-list-item"><a href="/wiki/Special:RecentChanges" title="A list of recent changes to Wikipedia [r]" accesskey="r"><span>Recent changes</span></a></li><li id="n-upload" class="mw-list-item"><a href="/wiki/Wikipedia:File_upload_wizard" title="Add images or other media for use on Wikipedia"><span>Upload file</span></a></li><li id="n-specialpages" class="mw-list-item"><a href="/wiki/Special:SpecialPages"><span>Special pages</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> <a href="/wiki/Main_Page" class="mw-logo"> <img class="mw-logo-icon" src="/static/images/icons/wikipedia.png" alt="" aria-hidden="true" height="50" width="50"> <span class="mw-logo-container skin-invert"> <img class="mw-logo-wordmark" alt="Wikipedia" src="/static/images/mobile/copyright/wikipedia-wordmark-en.svg" style="width: 7.5em; height: 1.125em;"> <img class="mw-logo-tagline" alt="The Free Encyclopedia" src="/static/images/mobile/copyright/wikipedia-tagline-en.svg" width="117" height="13" style="width: 7.3125em; height: 0.8125em;"> </span> </a> </div> <div class="vector-header-end"> <div id="p-search" role="search" class="vector-search-box-vue vector-search-box-collapses vector-search-box-show-thumbnail vector-search-box-auto-expand-width vector-search-box"> <a href="/wiki/Special:Search" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only search-toggle" title="Search Wikipedia [f]" accesskey="f"><span class="vector-icon mw-ui-icon-search mw-ui-icon-wikimedia-search"></span> <span>Search</span> </a> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail cdx-typeahead-search--auto-expand-width"> <form action="/w/index.php" id="searchform" class="cdx-search-input cdx-search-input--has-end-button"> <div id="simpleSearch" class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="Search Wikipedia" aria-label="Search Wikipedia" autocapitalize="sentences" title="Search Wikipedia [f]" accesskey="f" id="searchInput" > <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Special:Search"> </div> <button class="cdx-button cdx-search-input__end-button">Search</button> </form> </div> </div> </div> <nav class="vector-user-links vector-user-links-wide" aria-label="Personal tools"> <div class="vector-user-links-main"> <div id="p-vector-user-menu-preferences" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-userpage" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-dropdown" class="vector-dropdown " title="Change the appearance of the page's font size, width, and color" > <input type="checkbox" id="vector-appearance-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="Appearance" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">Appearance</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="https://donate.wikimedia.org/?wmf_source=donate&wmf_medium=sidebar&wmf_campaign=en.wikipedia.org&uselang=en" class=""><span>Donate</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:CreateAccount&returnto=Interleukin-15+receptor" title="You are encouraged to create an account and log in; however, it is not mandatory" class=""><span>Create account</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:UserLogin&returnto=Interleukin-15+receptor" title="You're encouraged to log in; however, it's not mandatory. [o]" accesskey="o" class=""><span>Log in</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Log in and more options" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Personal tools" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">Personal tools</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="User menu" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="https://donate.wikimedia.org/?wmf_source=donate&wmf_medium=sidebar&wmf_campaign=en.wikipedia.org&uselang=en"><span>Donate</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:CreateAccount&returnto=Interleukin-15+receptor" title="You are encouraged to create an account and log in; however, it is not mandatory"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>Create account</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:UserLogin&returnto=Interleukin-15+receptor" title="You're encouraged to log in; however, it's not mandatory. [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Log in</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Pages for logged out editors <a href="/wiki/Help:Introduction" aria-label="Learn more about editing"><span>learn more</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Special:MyContributions" title="A list of edits made from this IP address [y]" accesskey="y"><span>Contributions</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Special:MyTalk" title="Discussion about edits from this IP address [n]" accesskey="n"><span>Talk</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Contents" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Contents</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">hide</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">(Top)</div> </a> </li> <li id="toc-Structure" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Structure"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Structure</span> </div> </a> <ul id="toc-Structure-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Signaling" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Signaling"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Signaling</span> </div> </a> <ul id="toc-Signaling-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Function" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Function"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Function</span> </div> </a> <ul id="toc-Function-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Table of Contents" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Interleukin-15 receptor</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 1 language" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-1" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">1 language</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E7%99%BD%E4%BB%8B%E7%B4%A0-15%E5%8F%97%E4%BD%93" title="白介素-15受体 – Chinese" lang="zh" hreflang="zh" data-title="白介素-15受体" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q27312158#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Interleukin-15_receptor" title="View the content page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Talk:Interleukin-15_receptor" rel="discussion" title="Discuss improvements to the content page [t]" accesskey="t"><span>Talk</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Change language variant" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">English</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Views"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Interleukin-15_receptor"><span>Read</span></a></li><li id="ca-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Interleukin-15_receptor&action=edit" title="Edit this page [e]" accesskey="e"><span>Edit</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Interleukin-15_receptor&action=history" title="Past revisions of this page [h]" accesskey="h"><span>View history</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Tools" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Tools</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Tools</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">hide</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="More options" > <div class="vector-menu-heading"> Actions </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Interleukin-15_receptor"><span>Read</span></a></li><li id="ca-more-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interleukin-15_receptor&action=edit" title="Edit this page [e]" accesskey="e"><span>Edit</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interleukin-15_receptor&action=history"><span>View history</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> General </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Special:WhatLinksHere/Interleukin-15_receptor" title="List of all English Wikipedia pages containing links to this page [j]" accesskey="j"><span>What links here</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Special:RecentChangesLinked/Interleukin-15_receptor" rel="nofollow" title="Recent changes in pages linked from this page [k]" accesskey="k"><span>Related changes</span></a></li><li id="t-upload" class="mw-list-item"><a href="//en.wikipedia.org/wiki/Wikipedia:File_Upload_Wizard" title="Upload files [u]" accesskey="u"><span>Upload file</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Interleukin-15_receptor&oldid=1221322308" title="Permanent link to this revision of this page"><span>Permanent link</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Interleukin-15_receptor&action=info" title="More information about this page"><span>Page information</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Special:CiteThisPage&page=Interleukin-15_receptor&id=1221322308&wpFormIdentifier=titleform" title="Information on how to cite this page"><span>Cite this page</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Special:UrlShortener&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FInterleukin-15_receptor"><span>Get shortened URL</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Special:QrCode&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FInterleukin-15_receptor"><span>Download QR code</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Print/export </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Special:DownloadAsPdf&page=Interleukin-15_receptor&action=show-download-screen" title="Download this page as a PDF file"><span>Download as PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Interleukin-15_receptor&printable=yes" title="Printable version of this page [p]" accesskey="p"><span>Printable version</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> In other projects </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q27312158" title="Structured data on this page hosted by Wikidata [g]" accesskey="g"><span>Wikidata item</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein complex</div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above"><a href="/wiki/Interleukin_15_receptor,_alpha_subunit" title="Interleukin 15 receptor, alpha subunit">interleukin 15 receptor, alpha</a></th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Protein_IL15RA_PDB_2ers.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Protein_IL15RA_PDB_2ers.png/220px-Protein_IL15RA_PDB_2ers.png" decoding="async" width="220" height="134" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Protein_IL15RA_PDB_2ers.png/330px-Protein_IL15RA_PDB_2ers.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Protein_IL15RA_PDB_2ers.png/440px-Protein_IL15RA_PDB_2ers.png 2x" data-file-width="869" data-file-height="529" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/Interleukin_15_receptor,_alpha_subunit" title="Interleukin 15 receptor, alpha subunit">IL15RA</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/National_Center_for_Biotechnology_Information#Gene" title="National Center for Biotechnology Information">NCBI gene</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&list_uids=3601&rn=1">3601</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/HUGO_Gene_Nomenclature_Committee" title="HUGO Gene Nomenclature Committee">HGNC</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5978">5978</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://omim.org/entry/601070">601070</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/RefSeq" title="RefSeq">RefSeq</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NM_172200">NM_172200</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q13261">Q13261</a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Other data</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Locus</a></th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/Chromosome_10_(human)" class="mw-redirect" title="Chromosome 10 (human)">Chr. 10</a> <i><a rel="nofollow" class="external text" href="https://omim.org/search/?index=geneMap&search=10p15">p15-10p14</a></i></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search for</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Structures</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://swissmodel.expasy.org/repository/uniprot/Q13261">Swiss-model</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Domains</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/protein/Q13261">InterPro</a></td></tr></tbody></table></td></tr></tbody></table> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above"><a href="/wiki/IL2RB" title="IL2RB">interleukin 2 receptor, beta</a></th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Protein_IL2RB_PDB_2b5i.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fd/Protein_IL2RB_PDB_2b5i.png/220px-Protein_IL2RB_PDB_2b5i.png" decoding="async" width="220" height="187" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fd/Protein_IL2RB_PDB_2b5i.png/330px-Protein_IL2RB_PDB_2b5i.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fd/Protein_IL2RB_PDB_2b5i.png/440px-Protein_IL2RB_PDB_2b5i.png 2x" data-file-width="877" data-file-height="746" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/IL2RB" title="IL2RB">IL2RB</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Alt. symbols</th><td class="infobox-data" style="background-color: #eee">CD122</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/National_Center_for_Biotechnology_Information#Gene" title="National Center for Biotechnology Information">NCBI gene</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&list_uids=3560&rn=1">3560</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/HUGO_Gene_Nomenclature_Committee" title="HUGO Gene Nomenclature Committee">HGNC</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6009">6009</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://omim.org/entry/146710">146710</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/RefSeq" title="RefSeq">RefSeq</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NM_000878">NM_000878</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P14784">P14784</a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Other data</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Locus</a></th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/Chromosome_22_(human)" class="mw-redirect" title="Chromosome 22 (human)">Chr. 22</a> <i><a rel="nofollow" class="external text" href="https://omim.org/search/?index=geneMap&search=22q13">q13</a></i></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search for</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Structures</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://swissmodel.expasy.org/repository/uniprot/P14784">Swiss-model</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Domains</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/protein/P14784">InterPro</a></td></tr></tbody></table></td></tr></tbody></table> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above"><a href="/wiki/IL2RG" class="mw-redirect" title="IL2RG">interleukin 2 receptor, gamma (severe combined immunodeficiency)</a></th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Protein_IL2RG_PDB_2b5i.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/85/Protein_IL2RG_PDB_2b5i.png/220px-Protein_IL2RG_PDB_2b5i.png" decoding="async" width="220" height="187" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/85/Protein_IL2RG_PDB_2b5i.png/330px-Protein_IL2RG_PDB_2b5i.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/85/Protein_IL2RG_PDB_2b5i.png/440px-Protein_IL2RG_PDB_2b5i.png 2x" data-file-width="877" data-file-height="746" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/IL2RG" class="mw-redirect" title="IL2RG">IL2RG</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Alt. symbols</th><td class="infobox-data" style="background-color: #eee">SCIDX1, IMD4</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/National_Center_for_Biotechnology_Information#Gene" title="National Center for Biotechnology Information">NCBI gene</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&list_uids=3561&rn=1">3561</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/HUGO_Gene_Nomenclature_Committee" title="HUGO Gene Nomenclature Committee">HGNC</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6010">6010</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://omim.org/entry/308380">308380</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/RefSeq" title="RefSeq">RefSeq</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NM_000206">NM_000206</a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Other data</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Locus</a></th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/Chromosome_X_(human)" class="mw-redirect" title="Chromosome X (human)">Chr. X</a> <i><a rel="nofollow" class="external text" href="https://omim.org/search/?index=geneMap&search=Xq13">q13</a></i></td></tr></tbody></table> <p><b>Interleukin-15 receptor</b> is a <a href="/wiki/Type_I_cytokine_receptor" title="Type I cytokine receptor">type I cytokine receptor</a>, binding <a href="/wiki/Interleukin-15" class="mw-redirect" title="Interleukin-15">interleukin-15</a>.<sup id="cite_ref-pmid8530383_2-0" class="reference"><a href="#cite_note-pmid8530383-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin-15_receptor&action=edit&section=1" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The IL-15 receptor is composed of the <a href="/wiki/IL2RB" title="IL2RB">IL-2Rβ</a> and γc subunits, along with a unique ligand-specific subunit, IL-15Rα, which bears homology to <a href="/wiki/IL2RA" title="IL2RA">IL-2Rα</a>. These receptor proteins feature protein-binding motifs known as "sushi domains." In both humans and mice, these receptors and their corresponding ligands are physically linked in the genome. Due to their shared receptor usage, <a href="/wiki/Interleukin_2" title="Interleukin 2">IL-2</a> and IL-15 exhibit many similarities in their effects on lymphoid cells.<sup id="cite_ref-:0_3-0" class="reference"><a href="#cite_note-:0-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p><p>Although the receptors for IL-2 and IL-15 share many structural analogies, two significant differences persist: Firstly, IL-15Rα has a broader expression compared to IL-2Rα, IL-2Rβ, and γc. It is found on <a href="/wiki/Lymphocyte" title="Lymphocyte">lymphoid cells</a>, <a href="/wiki/Dendritic_cell" title="Dendritic cell">dendritic cells (DCs)</a>, <a href="/wiki/Fibroblast" title="Fibroblast">fibroblasts</a>, <a href="/wiki/Epithelium" title="Epithelium">epithelial cells</a>, <a href="/wiki/Hepatocyte" title="Hepatocyte">liver cells</a>, intestinal cells and other cells and is thought to present IL-15 in trans to cells expressing IL-15β and γ chains. Secondly, IL-15Rα exhibits a remarkably high affinity for binding to IL-15, over 1000 times greater than the affinity of IL-2Rα binding to IL-2.<sup id="cite_ref-pmid8530383_2-1" class="reference"><a href="#cite_note-pmid8530383-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:0_3-1" class="reference"><a href="#cite_note-:0-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Signaling">Signaling</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin-15_receptor&action=edit&section=2" title="Edit section: Signaling"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>IL-15-mediated signaling in T lymphocytes leads to the activation of <a href="/wiki/Janus_kinase" title="Janus kinase">Janus kinase</a> (JAK). JAKs play crucial signaling roles for several members of the cytokine receptor superfamily by activating signal transducer and activator of transcription (STAT) proteins. In lymphocytes, binding of IL-15 to the IL-2/15Rβγ heterodimer induces JAK1 activation that subsequently phosphorylates STAT3 via the β chain and JAK3/STAT5 activation via its γ chain.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Once tyrosine-phosphorylated, STAT transcription factors form homo- and/or heterodimers and migrate to the nucleus. There, they bind to target DNA regulatory elements and contribute to the activation of <a href="/wiki/Gene_expression" title="Gene expression">gene expression</a>.<sup id="cite_ref-:1_5-0" class="reference"><a href="#cite_note-:1-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>IL-15 also trigger other signaling pathways, including the phosphorylation of cytoplasmic tyrosine kinases from the <a href="/wiki/Src_family_kinase" title="Src family kinase">Src</a> family such as Lck, Fyn, and Lyn, along with Syk kinase. They also activate phosphatidylinositol 3 kinase (<a href="/wiki/Phosphoinositide_3-kinase" title="Phosphoinositide 3-kinase">PI3-kinase</a>) and Akt, leading to the induction of the anti-apoptotic protein Bcl-2. Additionally, they stimulate the Ras/Raf/MEK/mitogen-activated protein kinase (MAPK) pathway.<sup id="cite_ref-:1_5-1" class="reference"><a href="#cite_note-:1-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin-15_receptor&action=edit&section=3" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The signaling pathway of the IL-15/IL-15R system is now understood to affect not only T-cell functions but also various other cell populations. Several recent reviews have extensively explored the functional significance of IL-15/IL-15R biology in T lymphocyte development and <a href="/wiki/Homeostasis" title="Homeostasis">homeostasis</a>, as well as in the development, maintenance, expansion, and activities of memory CD8+ T cells and <a href="/wiki/Natural_killer_cell" title="Natural killer cell">NK cells</a>.<sup id="cite_ref-:1_5-2" class="reference"><a href="#cite_note-:1-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>One of the most defining functional differences between IL-2 and IL-15 is that IL-15 is increasingly acknowledged as a significant modulator of various non-immune cell types, whereas the functions of IL-2 are predominantly restricted to T cells.<sup id="cite_ref-:1_5-3" class="reference"><a href="#cite_note-:1-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin-15_receptor&action=edit&section=4" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-pmid16293754-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid16293754_1-0">^</a></b></span> <span class="reference-text"><span class="plainlinks"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a>: <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2B5I">2B5I</a></span><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFWangRickertGarcia2005" class="citation journal cs1">Wang X, Rickert M, Garcia KC (November 2005). "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors". <i>Science</i>. <b>310</b> (5751): <span class="nowrap">1159–</span>63. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2005Sci...310.1159W">2005Sci...310.1159W</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.1117893">10.1126/science.1117893</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16293754">16293754</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:85394260">85394260</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Science&rft.atitle=Structure+of+the+quaternary+complex+of+interleukin-2+with+its+alpha%2C+beta%2C+and+gammac+receptors&rft.volume=310&rft.issue=5751&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1159-%3C%2Fspan%3E63&rft.date=2005-11&rft_id=info%3Adoi%2F10.1126%2Fscience.1117893&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A85394260%23id-name%3DS2CID&rft_id=info%3Apmid%2F16293754&rft_id=info%3Abibcode%2F2005Sci...310.1159W&rft.aulast=Wang&rft.aufirst=X&rft.au=Rickert%2C+M&rft.au=Garcia%2C+KC&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin-15+receptor" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/Template:Cite_journal" title="Template:Cite journal">cite journal</a>}}</code>: CS1 maint: date and year (<a href="/wiki/Category:CS1_maint:_date_and_year" title="Category:CS1 maint: date and year">link</a>)</span></span> </li> <li id="cite_note-pmid8530383-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid8530383_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid8530383_2-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAndersonKumakiAhdiehBertles1995" class="citation journal cs1">Anderson DM, Kumaki S, Ahdieh M, Bertles J, Tometsko M, Loomis A, Giri J, Copeland NG, Gilbert DJ, Jenkins NA (1995). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.270.50.29862">"Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes"</a>. <i>J. Biol. Chem</i>. <b>270</b> (50): <span class="nowrap">29862–</span>9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.270.50.29862">10.1074/jbc.270.50.29862</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8530383">8530383</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Functional+characterization+of+the+human+interleukin-15+receptor+alpha+chain+and+close+linkage+of+IL15RA+and+IL2RA+genes&rft.volume=270&rft.issue=50&rft.pages=%3Cspan+class%3D%22nowrap%22%3E29862-%3C%2Fspan%3E9&rft.date=1995&rft_id=info%3Adoi%2F10.1074%2Fjbc.270.50.29862&rft_id=info%3Apmid%2F8530383&rft.aulast=Anderson&rft.aufirst=DM&rft.au=Kumaki%2C+S&rft.au=Ahdieh%2C+M&rft.au=Bertles%2C+J&rft.au=Tometsko%2C+M&rft.au=Loomis%2C+A&rft.au=Giri%2C+J&rft.au=Copeland%2C+NG&rft.au=Gilbert%2C+DJ&rft.au=Jenkins%2C+NA&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.270.50.29862&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin-15+receptor" class="Z3988"></span></span> </li> <li id="cite_note-:0-3"><span class="mw-cite-backlink">^ <a href="#cite_ref-:0_3-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:0_3-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFO'SheaGadinaSiegel2019" class="citation cs2">O'Shea JJ, Gadina M, Siegel RM (2019), <a rel="nofollow" class="external text" href="https://linkinghub.elsevier.com/retrieve/pii/B9780702068966000090">"Cytokines and Cytokine Receptors"</a>, <i>Clinical Immunology</i>, Elsevier, pp. 127–155.e1, <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fb978-0-7020-6896-6.00009-0">10.1016/b978-0-7020-6896-6.00009-0</a>, <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-7020-6896-6" title="Special:BookSources/978-0-7020-6896-6"><bdi>978-0-7020-6896-6</bdi></a><span class="reference-accessdate">, retrieved <span class="nowrap">2024-04-22</span></span></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Clinical+Immunology&rft.atitle=Cytokines+and+Cytokine+Receptors&rft.pages=127-155.e1&rft.date=2019&rft_id=info%3Adoi%2F10.1016%2Fb978-0-7020-6896-6.00009-0&rft.isbn=978-0-7020-6896-6&rft.aulast=O%27Shea&rft.aufirst=John+J.&rft.au=Gadina%2C+Massimo&rft.au=Siegel%2C+Richard+M.&rft_id=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FB9780702068966000090&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin-15+receptor" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMishraSullivanCaligiuri2014" class="citation journal cs1">Mishra A, Sullivan L, Caligiuri MA (2014-04-15). <a rel="nofollow" class="external text" href="https://aacrjournals.org/clincancerres/article/20/8/2044/78830/Molecular-Pathways-Interleukin-15-Signaling-in">"Molecular Pathways: Interleukin-15 Signaling in Health and in Cancer"</a>. <i>Clinical Cancer Research</i>. <b>20</b> (8): <span class="nowrap">2044–</span>2050. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1158%2F1078-0432.CCR-12-3603">10.1158/1078-0432.CCR-12-3603</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1078-0432">1078-0432</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989546">3989546</a></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Molecular+Pathways%3A+Interleukin-15+Signaling+in+Health+and+in+Cancer&rft.volume=20&rft.issue=8&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2044-%3C%2Fspan%3E2050&rft.date=2014-04-15&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3989546%23id-name%3DPMC&rft.issn=1078-0432&rft_id=info%3Adoi%2F10.1158%2F1078-0432.CCR-12-3603&rft.aulast=Mishra&rft.aufirst=Anjali&rft.au=Sullivan%2C+Laura&rft.au=Caligiuri%2C+Michael+A.&rft_id=https%3A%2F%2Faacrjournals.org%2Fclincancerres%2Farticle%2F20%2F8%2F2044%2F78830%2FMolecular-Pathways-Interleukin-15-Signaling-in&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin-15+receptor" class="Z3988"></span></span> </li> <li id="cite_note-:1-5"><span class="mw-cite-backlink">^ <a href="#cite_ref-:1_5-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:1_5-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:1_5-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-:1_5-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBudagianBulanovaPausBulfonepaus2006" class="citation journal cs1">Budagian V, Bulanova E, Paus R, Bulfonepaus S (August 2006). <a rel="nofollow" class="external text" href="https://linkinghub.elsevier.com/retrieve/pii/S135961010600030X">"IL-15/IL-15 receptor biology: A guided tour through an expanding universe"</a>. <i>Cytokine & Growth Factor Reviews</i>. <b>17</b> (4): <span class="nowrap">259–</span>280. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cytogfr.2006.05.001">10.1016/j.cytogfr.2006.05.001</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cytokine+%26+Growth+Factor+Reviews&rft.atitle=IL-15%2FIL-15+receptor+biology%3A+A+guided+tour+through+an+expanding+universe&rft.volume=17&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E259-%3C%2Fspan%3E280&rft.date=2006-08&rft_id=info%3Adoi%2F10.1016%2Fj.cytogfr.2006.05.001&rft.aulast=Budagian&rft.aufirst=V&rft.au=Bulanova%2C+E&rft.au=Paus%2C+R&rft.au=Bulfonepaus%2C+S&rft_id=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS135961010600030X&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin-15+receptor" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin-15_receptor&action=edit&section=5" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=Receptors%2C+Interleukin-15">Receptors,+Interleukin-15</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · ";font-weight:bold}.mw-parser-output .hlist dd:last-child::after,.mw-parser-output .hlist dt:last-child::after,.mw-parser-output .hlist li:last-child::after{content:none}.mw-parser-output .hlist dd dd:first-child::before,.mw-parser-output .hlist dd dt:first-child::before,.mw-parser-output .hlist dd li:first-child::before,.mw-parser-output .hlist dt dd:first-child::before,.mw-parser-output .hlist dt dt:first-child::before,.mw-parser-output .hlist dt li:first-child::before,.mw-parser-output .hlist li dd:first-child::before,.mw-parser-output .hlist li dt:first-child::before,.mw-parser-output .hlist li li:first-child::before{content:" (";font-weight:normal}.mw-parser-output .hlist dd dd:last-child::after,.mw-parser-output .hlist dd dt:last-child::after,.mw-parser-output .hlist dd li:last-child::after,.mw-parser-output .hlist dt dd:last-child::after,.mw-parser-output .hlist dt dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{padding:0.25em 1em;line-height:1.5em;text-align:center}.mw-parser-output .navbox-group{white-space:nowrap;text-align:right}.mw-parser-output .navbox,.mw-parser-output .navbox-subgroup{background-color:#fdfdfd}.mw-parser-output .navbox-list{line-height:1.5em;border-color:#fdfdfd}.mw-parser-output .navbox-list-with-group{text-align:left;border-left-width:2px;border-left-style:solid}.mw-parser-output tr+tr>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}body.skin--responsive .mw-parser-output .navbox-image img{max-width:none!important}@media print{body.ns-0 .mw-parser-output .navbox{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="Cytokine_receptors261" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Cytokine_receptors" title="Template:Cytokine receptors"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Cytokine_receptors" title="Template talk:Cytokine receptors"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Cytokine_receptors" title="Special:EditPage/Template:Cytokine receptors"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cytokine_receptors261" style="font-size:114%;margin:0 4em"><a href="/wiki/Cytokine_receptor" title="Cytokine receptor">Cytokine receptors</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Chemokine_receptor" title="Chemokine receptor">Chemokine receptor</a><br />(<a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">GPCRs</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/CC_chemokine_receptors" title="CC chemokine receptors">CC</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CCR1" title="CCR1">CCR1</a> / <a href="/wiki/CCRL1" title="CCRL1">CCRL1</a></li> <li><a href="/wiki/CCR2" title="CCR2">CCR2</a></li> <li><a href="/wiki/CCRL2" title="CCRL2">CCRL2</a></li> <li><a href="/wiki/CCR3_(gene)" title="CCR3 (gene)">CCR3</a></li> <li><a href="/wiki/CCR4" title="CCR4">CCR4</a></li> <li><a href="/wiki/CCR5" title="CCR5">CCR5</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_6" title="C-C chemokine receptor type 6">CCR6</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_7" title="C-C chemokine receptor type 7">CCR7</a></li> <li><a href="/wiki/CCR8_(gene)" title="CCR8 (gene)">CCR8</a></li> <li><a href="/wiki/CCR9" title="CCR9">CCR9</a></li> <li><a href="/wiki/CCR10" title="CCR10">CCR10</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/CXC_chemokine_receptors" title="CXC chemokine receptors">CXC</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin-8_receptor" title="Interleukin-8 receptor">IL-8</a> <ul><li><a href="/wiki/Interleukin_8_receptor,_alpha" title="Interleukin 8 receptor, alpha">CXCR1</a></li> <li><a href="/wiki/Interleukin_8_receptor,_beta" title="Interleukin 8 receptor, beta">CXCR2</a></li></ul></li> <li><a href="/wiki/CXCR3" title="CXCR3">CXCR3</a></li> <li><a href="/wiki/CXCR4" title="CXCR4">CXCR4</a></li> <li><a href="/wiki/CXCR5" title="CXCR5">CXCR5</a></li> <li><a href="/wiki/CXCR6" title="CXCR6">CXCR6</a></li> <li><a href="/wiki/ACKR3" title="ACKR3">CXCR7</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>CX3C <ul><li><a href="/wiki/CX3C_motif_chemokine_receptor_1" title="CX3C motif chemokine receptor 1">CX3CR1</a></li></ul></li> <li>XC <ul><li><a href="/wiki/XCR1" title="XCR1">XCR1</a></li></ul></li> <li><a href="/wiki/CCBP2" title="CCBP2">CCBP2</a></li> <li><a href="/wiki/CMKLR1" title="CMKLR1">CMKLR1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Tumor_necrosis_factor_receptor" class="mw-redirect" title="Tumor necrosis factor receptor">TNF receptor</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">1-10</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tumor_necrosis_factor_receptor_1" title="Tumor necrosis factor receptor 1">TNFR1</a> <i>(TNFRSF1A)</i></li> <li><a href="/wiki/Tumor_necrosis_factor_receptor_2" title="Tumor necrosis factor receptor 2">TNFR2</a> <i>(TNFRSF1B)</i></li> <li><a href="/wiki/Lymphotoxin_beta_receptor" title="Lymphotoxin beta receptor">LTBR</a> <i>(TNFRSF3)</i></li> <li><a href="/wiki/CD134" title="CD134">CD134</a> <i>(TNFRSF4)</i></li> <li><a href="/wiki/CD40_(protein)" title="CD40 (protein)">CD40</a> <i>(TNFRSF5)</i></li> <li><a href="/wiki/Fas_receptor" title="Fas receptor">Fas receptor</a> <i>(TNFRSF6)</i></li> <li><a href="/wiki/DcR3" class="mw-redirect" title="DcR3">DcR3</a> <i>(TNFRSF6B)</i></li> <li><a href="/wiki/CD27" title="CD27">CD27</a> <i>(TNFRSF7)</i></li> <li><a href="/wiki/CD30" title="CD30">CD30</a> <i>(TNFRSF8)</i></li> <li><a href="/wiki/CD137" title="CD137">CD137</a> <i>(TNFRSF9)</i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">11-20</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Death_receptor_4" title="Death receptor 4">DR4</a> <i>(TNFRSF10A)</i></li> <li><a href="/wiki/Death_receptor_5" title="Death receptor 5">DR5</a> <i>(TNFRSF10B)</i></li> <li><a href="/wiki/Decoy_receptor_1" title="Decoy receptor 1">DcR1</a> <i>(TNFRSF10C)</i></li> <li><a href="/wiki/Decoy_receptor_2" title="Decoy receptor 2">DcR2</a> <i>(TNFRSF10D)</i></li> <li><a href="/wiki/RANK" title="RANK">RANK</a> <i>(TNFRSF11A)</i></li> <li><a href="/wiki/Osteoprotegerin" title="Osteoprotegerin">Osteoprotegerin</a> <i>(TNFRSF11B)</i></li> <li><a href="/wiki/TNFRSF12A" title="TNFRSF12A">TweakR</a> <i>(TNFRSF12A)</i></li> <li><a href="/wiki/TNFRSF13B" class="mw-redirect" title="TNFRSF13B">TACI</a> <i>(TNFRSF13B)</i></li> <li><a href="/wiki/TNFRSF13C" class="mw-redirect" title="TNFRSF13C">BAFFR</a> <i>(TNFRSF13C)</i></li> <li><a href="/wiki/TNFRSF14" class="mw-redirect" title="TNFRSF14">HVEM</a> <i>(TNFRSF14)</i></li> <li><a href="/wiki/Low-affinity_nerve_growth_factor_receptor" title="Low-affinity nerve growth factor receptor">NGFR</a> <i>(TNFRSF16)</i></li> <li><a href="/wiki/TNFRSF17" class="mw-redirect" title="TNFRSF17">BCMA</a> <i>(TNFRSF17)</i></li> <li><a href="/wiki/TNFRSF18" title="TNFRSF18">GITR</a> <i>(TNFRSF18)</i></li> <li><a href="/wiki/TNFRSF19" title="TNFRSF19">TAJ/TROY</a> <i>(TNFRSF19)</i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">21-27</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Death_receptor_6" title="Death receptor 6">DR6</a> <i>(TNFRSF21)</i></li> <li><a href="/wiki/Death_receptor_3" title="Death receptor 3">DR3</a> <i>(TNFRSF25)</i></li> <li><a href="/wiki/Ectodysplasin_A2_receptor" title="Ectodysplasin A2 receptor">EDA2R</a> <i>(TNFRSF27)</i></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/JAK-STAT_signaling_pathway" title="JAK-STAT signaling pathway">JAK-STAT</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Type_I_cytokine_receptor" title="Type I cytokine receptor">Type I</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Common_gamma_chain" title="Common gamma chain">γ-chain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/IL-2_receptor" title="IL-2 receptor">IL2R</a> / <a href="/wiki/IL2RA" title="IL2RA">IL2RA</a>/<a href="/wiki/IL2RB" title="IL2RB">IL2RB</a> / <a class="mw-selflink selflink">IL15R</a></li> <li><a href="/wiki/Interleukin-4_receptor" title="Interleukin-4 receptor">IL4R</a> / <a href="/wiki/Interleukin-13_receptor" title="Interleukin-13 receptor">IL13R</a> / <a href="/wiki/Interleukin_13_receptor,_alpha_1" title="Interleukin 13 receptor, alpha 1">IL13RA1</a> / <a href="/wiki/IL13RA2" title="IL13RA2">IL13RA2</a></li> <li><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">IL7R</a> / <a href="/wiki/Interleukin-7_receptor-%CE%B1" title="Interleukin-7 receptor-α">IL7RA</a></li> <li><a href="/wiki/Interleukin-9_receptor" title="Interleukin-9 receptor">IL9R</a></li> <li><a href="/wiki/Interleukin-21_receptor" title="Interleukin-21 receptor">IL21R</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/CSF2RB" title="CSF2RB">β-chain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/Interleukin-3_receptor" title="Interleukin-3 receptor">IL3R</a> / <a href="/wiki/IL3RA" title="IL3RA">IL3RA</a></li> <li><a href="/wiki/Interleukin-5_receptor" title="Interleukin-5 receptor">IL5R</a> / <a href="/wiki/Interleukin_5_receptor_alpha_subunit" title="Interleukin 5 receptor alpha subunit">IL5RA</a></li></ul></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor receptor">GM-CSF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Glycoprotein_130" title="Glycoprotein 130">gp130</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">IL6RA</a></li> <li><a href="/wiki/Interleukin-11_receptor" title="Interleukin-11 receptor">11</a>/<a href="/wiki/Interleukin_11_receptor_alpha_subunit" title="Interleukin 11 receptor alpha subunit">IL11RA</a></li> <li><a href="/wiki/Interleukin-27_receptor" title="Interleukin-27 receptor">27</a>/<a href="/wiki/Interleukin_27_receptor,_alpha_subunit" title="Interleukin 27 receptor, alpha subunit">IL27RA</a></li></ul></li> <li><a href="/wiki/Oncostatin_M_receptor" title="Oncostatin M receptor">OSMR</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor_receptor" title="Leukemia inhibitory factor receptor">LIFR</a></li> <li><a href="/wiki/Ciliary_neurotrophic_factor_receptor" title="Ciliary neurotrophic factor receptor">CNTFR</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">IL12RB1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/Interleukin-12_receptor" title="Interleukin-12 receptor">IL12R</a>/<a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">IL12RB1</a>/<a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">IL12RB2</a></li> <li><a href="/wiki/Interleukin-23_receptor" title="Interleukin-23 receptor">IL23R</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>other <a href="/wiki/CSF_receptors" class="mw-redirect" title="CSF receptors">CSF receptors</a> <ul><li><a href="/wiki/Erythropoietin_receptor" title="Erythropoietin receptor">EPO</a></li> <li><a href="/wiki/Granulocyte_colony-stimulating_factor_receptor" title="Granulocyte colony-stimulating factor receptor">G-CSF</a></li> <li><a href="/wiki/Thrombopoietin_receptor" title="Thrombopoietin receptor">Thrombopoietin</a></li></ul></li></ul> <ul><li><a href="/wiki/Hormone_receptor" title="Hormone receptor">hormone receptor</a>: <a href="/wiki/Growth_hormone_receptor" title="Growth hormone receptor">GH</a></li> <li><a href="/wiki/Prolactin_receptor" title="Prolactin receptor">prolactin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Type_II_cytokine_receptor" title="Type II cytokine receptor">Type II</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/Interleukin-10_receptor" title="Interleukin-10 receptor">IL10R</a> / <a href="/wiki/Interleukin_10_receptor,_alpha_subunit" title="Interleukin 10 receptor, alpha subunit">IL10RA</a> / <a href="/wiki/Interleukin_10_receptor,_beta_subunit" title="Interleukin 10 receptor, beta subunit">IL10RB</a> / <a href="/wiki/Interleukin-22_receptor" title="Interleukin-22 receptor">IL22R</a> / <a href="/wiki/IL22RA1" title="IL22RA1">IL22RA1</a> / <a href="/wiki/IL22RA2" title="IL22RA2">IL22RA2</a></li> <li><a href="/wiki/Interleukin-20_receptor" title="Interleukin-20 receptor">IL20R</a> / <a href="/wiki/Interleukin_20_receptor,_alpha_subunit" title="Interleukin 20 receptor, alpha subunit">IL20RA</a> / <a href="/wiki/Interleukin_20_receptor,_beta_subunit" title="Interleukin 20 receptor, beta subunit">IL20RB</a></li> <li><a href="/wiki/Interleukin-28_receptor" title="Interleukin-28 receptor">IL28R</a></li></ul></li> <li><a href="/wiki/Interferon_receptor" class="mw-redirect" title="Interferon receptor">Interferon receptors</a> <ul><li><a href="/wiki/Interferon-alpha/beta_receptor" title="Interferon-alpha/beta receptor">-α/β</a> / <a href="/wiki/IFNAR1" title="IFNAR1">IFNAR1</a>/<a href="/wiki/IFNAR2" title="IFNAR2">IFNAR2</a></li> <li><a href="/wiki/Interferon-gamma_receptor" title="Interferon-gamma receptor">-γ</a>/<a href="/wiki/Interferon_gamma_receptor_1" title="Interferon gamma receptor 1">IFNGR1</a> / <a href="/wiki/Interferon_gamma_receptor_2" title="Interferon gamma receptor 2">IFNGR2</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Immunoglobulin_superfamily" title="Immunoglobulin superfamily">Ig superfamily</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li class="mw-empty-elt"></li> <li><a href="/wiki/Interleukin-1_receptor" title="Interleukin-1 receptor">IL1</a> <ul><li><a href="/wiki/Interleukin_1_receptor,_type_I" title="Interleukin 1 receptor, type I">IL1R1</a></li> <li><a href="/wiki/Interleukin_1_receptor,_type_II" title="Interleukin 1 receptor, type II">IL1R2</a></li></ul></li> <li><a href="/wiki/Interleukin-18_receptor" title="Interleukin-18 receptor">IL18R</a> / <a href="/wiki/IL18R1" title="IL18R1">IL18R1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/IL_17_family" class="mw-redirect" title="IL 17 family">IL 17 family</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin-17_receptor" title="Interleukin-17 receptor">IL17</a> <ul><li><a href="/wiki/IL17RA" title="IL17RA">IL17RA</a></li> <li><a href="/wiki/IL17RB" title="IL17RB">IL17RB</a></li> <li><a href="/wiki/IL17RC" title="IL17RC">IL17RC</a></li> <li><a href="/wiki/IL17RD" title="IL17RD">IL17RD</a></li> <li><a href="/w/index.php?title=IL17RE&action=edit&redlink=1" class="new" title="IL17RE (page does not exist)">IL17RE</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Enzyme-linked_receptor" title="Enzyme-linked receptor">Enzyme-linked receptor</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Receptor_tyrosine_kinase" title="Receptor tyrosine kinase">Tyr</a> <ul><li><a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">CSF1R</a></li> <li><a href="/wiki/CD117" class="mw-redirect" title="CD117">KIT</a></li></ul></li> <li><a href="/wiki/Receptor_protein_serine/threonine_kinase" title="Receptor protein serine/threonine kinase">Ser/Thr</a>: <a href="/wiki/TGF_beta_receptors" class="mw-redirect" title="TGF beta receptors">TGF-beta</a> <ul><li><a href="/wiki/TGF_beta_receptor_1" title="TGF beta receptor 1">TGFBR1</a></li> <li><a href="/wiki/TGF_beta_receptor_2" title="TGF beta receptor 2">TGFBR2</a></li> <li><a href="/wiki/TGF-beta_receptor_family" title="TGF-beta receptor family">family</a></li></ul></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Interleukin_receptor_modulators601" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Interleukin_receptor_modulators" title="Template:Interleukin receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Interleukin_receptor_modulators" title="Template talk:Interleukin receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Interleukin_receptor_modulators" title="Special:EditPage/Template:Interleukin receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Interleukin_receptor_modulators601" style="font-size:114%;margin:0 4em"><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-1_receptor" title="Interleukin-1 receptor">IL-1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_1" class="mw-redirect" title="Interleukin 1">Interleukin 1</a> (<a href="/wiki/Interleukin_1_alpha" class="mw-redirect" title="Interleukin 1 alpha">α</a>, <a href="/wiki/Interleukin_1_beta" title="Interleukin 1 beta">β</a>)</li> <li><a href="/w/index.php?title=Mobenakin&action=edit&redlink=1" class="new" title="Mobenakin (page does not exist)">Mobenakin</a></li> <li><a href="/w/index.php?title=Pifonakin&action=edit&redlink=1" class="new" title="Pifonakin (page does not exist)">Pifonakin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=AF-12198&action=edit&redlink=1" class="new" title="AF-12198 (page does not exist)">AF-12198</a></li> <li><a href="/wiki/Anakinra" title="Anakinra">Anakinra</a></li> <li><a href="/wiki/Interleukin_1_receptor_antagonist" class="mw-redirect" title="Interleukin 1 receptor antagonist">IL-1RA</a></li> <li><a href="/w/index.php?title=Isunakinra&action=edit&redlink=1" class="new" title="Isunakinra (page does not exist)">Isunakinra</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Canakinumab" title="Canakinumab">Canakinumab</a></li> <li><a href="/wiki/Gevokizumab" title="Gevokizumab">Gevokizumab</a></li> <li><a href="/w/index.php?title=Lutikizumab&action=edit&redlink=1" class="new" title="Lutikizumab (page does not exist)">Lutikizumab</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Rilonacept" title="Rilonacept">Rilonacept (IL-1 Trap)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-2_receptor" class="mw-redirect" title="Interleukin-2 receptor">IL-2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Adargileukin_alfa&action=edit&redlink=1" class="new" title="Adargileukin alfa (page does not exist)">Adargileukin alfa</a></li> <li><a href="/wiki/Aldesleukin" class="mw-redirect" title="Aldesleukin">Aldesleukin</a></li> <li><a href="/w/index.php?title=Celmoleukin&action=edit&redlink=1" class="new" title="Celmoleukin (page does not exist)">Celmoleukin</a></li> <li><a href="/wiki/Denileukin_diftitox" title="Denileukin diftitox">Denileukin diftitox</a></li> <li><a href="/wiki/Interleukin_2" title="Interleukin 2">Interleukin 2</a></li> <li><a href="/w/index.php?title=Pegaldesleukin&action=edit&redlink=1" class="new" title="Pegaldesleukin (page does not exist)">Pegaldesleukin</a></li> <li><a href="/w/index.php?title=Teceleukin&action=edit&redlink=1" class="new" title="Teceleukin (page does not exist)">Teceleukin</a></li> <li><a href="/wiki/Tucotuzumab_celmoleukin" title="Tucotuzumab celmoleukin">Tucotuzumab celmoleukin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Basiliximab" title="Basiliximab">Basiliximab</a></li> <li><a href="/wiki/Daclizumab" title="Daclizumab">Daclizumab (dacliximab)</a></li> <li><a href="/wiki/Inolimomab" title="Inolimomab">Inolimomab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-3_receptor" title="Interleukin-3 receptor">IL-3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Daniplestim&action=edit&redlink=1" class="new" title="Daniplestim (page does not exist)">Daniplestim</a></li> <li><a href="/wiki/Interleukin_3" title="Interleukin 3">Interleukin 3</a></li> <li><a href="/w/index.php?title=Leridistim&action=edit&redlink=1" class="new" title="Leridistim (page does not exist)">Leridistim</a></li> <li><a href="/w/index.php?title=Milodistim&action=edit&redlink=1" class="new" title="Milodistim (page does not exist)">Milodistim</a></li> <li><a href="/w/index.php?title=Muplestim&action=edit&redlink=1" class="new" title="Muplestim (page does not exist)">Muplestim</a></li> <li><a href="/wiki/Promegapoietin" title="Promegapoietin">Promegapoietin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-4_receptor" title="Interleukin-4 receptor">IL-4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Binetrakin&action=edit&redlink=1" class="new" title="Binetrakin (page does not exist)">Binetrakin</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">Interleukin 4</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">Interleukin 13</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Pitrakinra" title="Pitrakinra">Pitrakinra</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Dupilumab" title="Dupilumab">Dupilumab</a></li> <li><a href="/wiki/Pascolizumab" title="Pascolizumab">Pascolizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-5_receptor" title="Interleukin-5 receptor">IL-5</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_5" title="Interleukin 5">Interleukin 5</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=YM-90709&action=edit&redlink=1" class="new" title="YM-90709 (page does not exist)">YM-90709</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Benralizumab" title="Benralizumab">Benralizumab</a></li> <li><a href="/wiki/Mepolizumab" title="Mepolizumab">Mepolizumab</a></li> <li><a href="/wiki/Reslizumab" title="Reslizumab">Reslizumab</a></li></ul> <ul><li><i>Antisense oligonucleotides:</i> <a href="/w/index.php?title=TPI_ASM8&action=edit&redlink=1" class="new" title="TPI ASM8 (page does not exist)">TPI ASM8</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">IL-6</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Atexakin_alfa&action=edit&redlink=1" class="new" title="Atexakin alfa (page does not exist)">Atexakin alfa</a></li> <li><a href="/wiki/Interleukin_6" title="Interleukin 6">Interleukin 6</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=ARGX-109&action=edit&redlink=1" class="new" title="ARGX-109 (page does not exist)">ARGX-109</a></li> <li><a href="/wiki/Clazakizumab" title="Clazakizumab">Clazakizumab</a></li> <li><a href="/wiki/Elsilimomab" title="Elsilimomab">Elsilimomab</a></li> <li><a href="/w/index.php?title=MAb_1339&action=edit&redlink=1" class="new" title="MAb 1339 (page does not exist)">mAb 1339</a></li> <li><a href="/wiki/Olokizumab" title="Olokizumab">Olokizumab</a></li> <li><a href="/wiki/Sarilumab" title="Sarilumab">Sarilumab</a></li> <li><a href="/wiki/Siltuximab" title="Siltuximab">Siltuximab</a></li> <li><a href="/wiki/Sirukumab" title="Sirukumab">Sirukumab</a></li> <li><a href="/wiki/Tocilizumab" title="Tocilizumab">Tocilizumab</a></li> <li><a href="/wiki/Levilimab" title="Levilimab">Levilimab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">IL-7</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_7" title="Interleukin 7">Interleukin 7</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-8_receptor" title="Interleukin-8 receptor">IL-8</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) <a href="/wiki/Template:Chemokine_receptor_modulators" title="Template:Chemokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_9_receptor" class="mw-redirect" title="Interleukin 9 receptor">IL-9</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_9" title="Interleukin 9">Interleukin 9</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=Enokizumab&action=edit&redlink=1" class="new" title="Enokizumab (page does not exist)">Enokizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-10_receptor" title="Interleukin-10 receptor">IL-10</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ilodecakin&action=edit&redlink=1" class="new" title="Ilodecakin (page does not exist)">Ilodecakin</a></li> <li><a href="/wiki/Interleukin_10" title="Interleukin 10">Interleukin 10 (CSIF)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-11_receptor" title="Interleukin-11 receptor">IL-11</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_11" title="Interleukin 11">Interleukin 11 (AGIF)</a></li> <li><a href="/wiki/Oprelvekin" title="Oprelvekin">Oprelvekin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-12_receptor" title="Interleukin-12 receptor">IL-12</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Edodekin_alfa&action=edit&redlink=1" class="new" title="Edodekin alfa (page does not exist)">Edodekin alfa</a></li> <li><a href="/wiki/Interleukin_12" title="Interleukin 12">Interleukin 12</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-13_receptor" title="Interleukin-13 receptor">IL-13</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Binetrakin&action=edit&redlink=1" class="new" title="Binetrakin (page does not exist)">Binetrakin</a></li> <li><a href="/w/index.php?title=Cintredekin_besudotox&action=edit&redlink=1" class="new" title="Cintredekin besudotox (page does not exist)">Cintredekin besudotox</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">Interleukin 4</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">Interleukin 13</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Anrukinzumab" title="Anrukinzumab">Anrukinzumab</a></li> <li><a href="/wiki/Lebrikizumab" title="Lebrikizumab">Lebrikizumab</a></li> <li><a href="/wiki/Tralokinumab" title="Tralokinumab">Tralokinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a class="mw-selflink selflink">IL-15</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/ALT-803" class="mw-redirect" title="ALT-803">ALT-803</a></li> <li><a href="/wiki/Interleukin_15" title="Interleukin 15">Interleukin 15</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-17_receptor" title="Interleukin-17 receptor">IL-17</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_17" title="Interleukin 17">Interleukin 17</a> (<a href="/wiki/IL17A" class="mw-redirect" title="IL17A">A</a>, <a href="/w/index.php?title=IL17B&action=edit&redlink=1" class="new" title="IL17B (page does not exist)">B</a>, <a href="/w/index.php?title=IL17C&action=edit&redlink=1" class="new" title="IL17C (page does not exist)">C</a>, <a href="/w/index.php?title=IL17D&action=edit&redlink=1" class="new" title="IL17D (page does not exist)">D</a>, <a href="/wiki/IL17E" class="mw-redirect" title="IL17E">E (interleukin 25)</a>, <a href="/wiki/IL17F" class="mw-redirect" title="IL17F">F</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Brodalumab" title="Brodalumab">Brodalumab</a></li> <li><a href="/wiki/Ixekizumab" title="Ixekizumab">Ixekizumab</a></li> <li><a href="/wiki/Perakizumab" title="Perakizumab">Perakizumab</a></li> <li><a href="/w/index.php?title=Remtolumab&action=edit&redlink=1" class="new" title="Remtolumab (page does not exist)">Remtolumab</a></li> <li><a href="/wiki/Secukinumab" title="Secukinumab">Secukinumab</a></li> <li><a href="/w/index.php?title=Vunakizumab&action=edit&redlink=1" class="new" title="Vunakizumab (page does not exist)">Vunakizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-18_receptor" title="Interleukin-18 receptor">IL-18</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Iboctadekin&action=edit&redlink=1" class="new" title="Iboctadekin (page does not exist)">Iboctadekin</a></li> <li><a href="/wiki/Interleukin_18" title="Interleukin 18">Interleukin 18</a></li> <li><a href="/wiki/Interleukin_37" title="Interleukin 37">Interleukin 37</a></li> <li><a href="/w/index.php?title=Tadekinig&action=edit&redlink=1" class="new" title="Tadekinig (page does not exist)">Tadekinig</a></li></ul> <ul><li><i>Binding proteins:</i> <a href="/wiki/IL18BP" title="IL18BP">IL18BP</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-20_receptor" title="Interleukin-20 receptor">IL-20</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_19" title="Interleukin 19">Interleukin 19</a></li> <li><a href="/wiki/Interleukin_20" title="Interleukin 20">Interleukin 20</a></li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">Interleukin 24</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fletikumab" title="Fletikumab">Fletikumab</a> (against IL-20)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-21_receptor" title="Interleukin-21 receptor">IL-21</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Denenicokin&action=edit&redlink=1" class="new" title="Denenicokin (page does not exist)">Denenicokin</a></li> <li><a href="/wiki/Interleukin_21" title="Interleukin 21">Interleukin 21</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=NNC0114-0005&action=edit&redlink=1" class="new" title="NNC0114-0005 (page does not exist)">NNC0114-0005</a></li> <li><a href="/w/index.php?title=NNC0114-0006&action=edit&redlink=1" class="new" title="NNC0114-0006 (page does not exist)">NNC0114-0006</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-22_receptor" title="Interleukin-22 receptor">IL-22</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_22" title="Interleukin 22">Interleukin 22</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fezakinumab" title="Fezakinumab">Fezakinumab</a> (against IL-22)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-23_receptor" title="Interleukin-23 receptor">IL-23</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_23" title="Interleukin 23">Interleukin 23 (SGRF)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Brazikumab" title="Brazikumab">Brazikumab</a></li> <li><a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Guselkumab" title="Guselkumab">Guselkumab</a></li> <li><a href="/wiki/Risankizumab" title="Risankizumab">Risankizumab</a></li> <li><a href="/wiki/Tildrakizumab" title="Tildrakizumab">Tildrakizumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-27_receptor" title="Interleukin-27 receptor">IL-27</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_27" title="Interleukin 27">Interleukin 27 (interleukin 30)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-28_receptor" title="Interleukin-28 receptor">IL-28</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Interferon_%CE%BB4&action=edit&redlink=1" class="new" title="Interferon λ4 (page does not exist)">Interferon λ4 (IFN-λ4)</a></li> <li><a href="/wiki/Interleukin_28" title="Interleukin 28">Interleukin 28</a> (<a href="/w/index.php?title=Interleukin_28A&action=edit&redlink=1" class="new" title="Interleukin 28A (page does not exist)">A (IFN-λ2)</a>, <a href="/wiki/Interleukin_28B" class="mw-redirect" title="Interleukin 28B">B (IFN-λ3)</a>)</li> <li><a href="/wiki/Interleukin_29" title="Interleukin 29">Interleukin-29 (IFN-λ1)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-31_receptor" title="Interleukin-31 receptor">IL-31</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_31" title="Interleukin 31">Interleukin 31</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_1_receptor-like_1" class="mw-redirect" title="Interleukin 1 receptor-like 1">IL1RL1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_33" title="Interleukin 33">Interleukin 33</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_1_receptor-like_2" class="mw-redirect" title="Interleukin 1 receptor-like 2">IL1RL2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_36" title="Interleukin 36">Interleukin 36</a> (<a href="/wiki/IL36A" title="IL36A">α</a>, <a href="/wiki/IL36B" title="IL36B">β</a>, <a href="/wiki/IL36G" title="IL36G">γ</a>)</li> <li><a href="/wiki/Interleukin_38" class="mw-redirect" title="Interleukin 38">Interleukin 38</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Interleukin_36_receptor_antagonist" title="Interleukin 36 receptor antagonist">IL-36RA</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Janus_kinase" title="Janus kinase">JAK</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_14" class="mw-redirect" title="Interleukin 14">Interleukin 14 (taxilin alpha, HMW-BCGF)</a></li> <li><a href="/wiki/Interleukin_16" title="Interleukin 16">Interleukin 16</a> (signals through <a href="/wiki/CD4" title="CD4">CD4</a>)</li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">Interleukin 24</a> (signals through <a href="/wiki/IL22RA1" title="IL22RA1">IL-22Rα1</a>/<a href="/wiki/Interleukin_20_receptor,_beta_subunit" title="Interleukin 20 receptor, beta subunit">IL-20Rβ</a> heterodimer)</li> <li><a href="/wiki/Interleukin_26" title="Interleukin 26">Interleukin 26</a> (signals through <a href="/wiki/Interleukin_20_receptor,_alpha_subunit" title="Interleukin 20 receptor, alpha subunit">IL-20Rα</a>/<a href="/wiki/Interleukin_10_receptor,_beta_subunit" title="Interleukin 10 receptor, beta subunit">IL-10Rβ</a> heterodimer)</li> <li><a href="/wiki/Interleukin_32" title="Interleukin 32">Interleukin 32</a></li> <li><a href="/wiki/Interleukin_34" title="Interleukin 34">Interleukin 34</a> (signals through <a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">M-CSFR/CSF1R</a>)</li> <li><a href="/wiki/Interleukin_35" title="Interleukin 35">Interleukin 35</a></li></ul> <ul><li><i>Unsorted:</i> <a href="/wiki/Efavaleukin_alfa" title="Efavaleukin alfa">Efavaleukin alfa</a></li> <li><a href="/w/index.php?title=Efineptakin_alfa&action=edit&redlink=1" class="new" title="Efineptakin alfa (page does not exist)">Efineptakin alfa</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Interleukin-15_receptor&oldid=1221322308">https://en.wikipedia.org/w/index.php?title=Interleukin-15_receptor&oldid=1221322308</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Genes_on_human_chromosome_10" title="Category:Genes on human chromosome 10">Genes on human chromosome 10</a></li><li><a href="/wiki/Category:Genes_on_human_chromosome_22" title="Category:Genes on human chromosome 22">Genes on human chromosome 22</a></li><li><a href="/wiki/Category:Genes_on_human_chromosome_X" title="Category:Genes on human chromosome X">Genes on human chromosome X</a></li><li><a href="/wiki/Category:Type_I_cytokine_receptors" title="Category:Type I cytokine receptors">Type I cytokine receptors</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden categories: <ul><li><a href="/wiki/Category:CS1_maint:_date_and_year" title="Category:CS1 maint: date and year">CS1 maint: date and year</a></li><li><a href="/wiki/Category:Articles_with_short_description" title="Category:Articles with short description">Articles with short description</a></li><li><a href="/wiki/Category:Short_description_is_different_from_Wikidata" title="Category:Short description is different from Wikidata">Short description is different from Wikidata</a></li><li><a href="/wiki/Category:Pages_using_infobox_protein_with_unknown_parameters" title="Category:Pages using infobox protein with unknown parameters">Pages using infobox protein with unknown parameters</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> This page was last edited on 29 April 2024, at 06:50<span class="anonymous-show"> (UTC)</span>.</li> <li id="footer-info-copyright">Text is available under the <a href="/wiki/Wikipedia:Text_of_the_Creative_Commons_Attribution-ShareAlike_4.0_International_License" title="Wikipedia:Text of the Creative Commons Attribution-ShareAlike 4.0 International License">Creative Commons Attribution-ShareAlike 4.0 License</a>; additional terms may apply. By using this site, you agree to the <a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Terms_of_Use" class="extiw" title="foundation:Special:MyLanguage/Policy:Terms of Use">Terms of Use</a> and <a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy" class="extiw" title="foundation:Special:MyLanguage/Policy:Privacy policy">Privacy Policy</a>. Wikipedia® is a registered trademark of the <a rel="nofollow" class="external text" href="https://wikimediafoundation.org/">Wikimedia Foundation, Inc.</a>, a non-profit organization.</li> </ul> <ul id="footer-places"> <li id="footer-places-privacy"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy">Privacy policy</a></li> <li id="footer-places-about"><a href="/wiki/Wikipedia:About">About Wikipedia</a></li> <li id="footer-places-disclaimers"><a href="/wiki/Wikipedia:General_disclaimer">Disclaimers</a></li> <li id="footer-places-contact"><a href="//en.wikipedia.org/wiki/Wikipedia:Contact_us">Contact Wikipedia</a></li> <li id="footer-places-wm-codeofconduct"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Universal_Code_of_Conduct">Code of Conduct</a></li> <li id="footer-places-developers"><a href="https://developer.wikimedia.org">Developers</a></li> <li id="footer-places-statslink"><a href="https://stats.wikimedia.org/#/en.wikipedia.org">Statistics</a></li> <li id="footer-places-cookiestatement"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Cookie_statement">Cookie statement</a></li> <li id="footer-places-mobileview"><a href="//en.m.wikipedia.org/w/index.php?title=Interleukin-15_receptor&mobileaction=toggle_view_mobile" class="noprint stopMobileRedirectToggle">Mobile view</a></li> </ul> <ul id="footer-icons" class="noprint"> <li id="footer-copyrightico"><a href="https://wikimediafoundation.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><picture><source media="(min-width: 500px)" srcset="/static/images/footer/wikimedia-button.svg" width="84" height="29"><img src="/static/images/footer/wikimedia.svg" width="25" height="25" alt="Wikimedia Foundation" lang="en" loading="lazy"></picture></a></li> <li id="footer-poweredbyico"><a href="https://www.mediawiki.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><picture><source media="(min-width: 500px)" srcset="/w/resources/assets/poweredby_mediawiki.svg" width="88" height="31"><img src="/w/resources/assets/mediawiki_compact.svg" alt="Powered by MediaWiki" width="25" height="25" loading="lazy"></picture></a></li> </ul> </footer> </div> </div> </div> <div class="vector-header-container vector-sticky-header-container"> <div id="vector-sticky-header" class="vector-sticky-header"> <div class="vector-sticky-header-start"> <div class="vector-sticky-header-icon-start vector-button-flush-left vector-button-flush-right" aria-hidden="true"> <button class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-sticky-header-search-toggle" tabindex="-1" data-event-name="ui.vector-sticky-search-form.icon"><span class="vector-icon mw-ui-icon-search mw-ui-icon-wikimedia-search"></span> <span>Search</span> </button> </div> <div role="search" class="vector-search-box-vue vector-search-box-show-thumbnail vector-search-box"> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail"> <form action="/w/index.php" id="vector-sticky-search-form" class="cdx-search-input cdx-search-input--has-end-button"> <div class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="Search Wikipedia"> <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Special:Search"> </div> <button class="cdx-button cdx-search-input__end-button">Search</button> </form> </div> </div> </div> <div class="vector-sticky-header-context-bar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-sticky-header-toc" class="vector-dropdown mw-portlet mw-portlet-sticky-header-toc vector-sticky-header-toc vector-button-flush-left" > <input type="checkbox" id="vector-sticky-header-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-sticky-header-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-sticky-header-toc-label" for="vector-sticky-header-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-sticky-header-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div class="vector-sticky-header-context-bar-primary" aria-hidden="true" ><span class="mw-page-title-main">Interleukin-15 receptor</span></div> </div> </div> <div class="vector-sticky-header-end" aria-hidden="true"> <div class="vector-sticky-header-icons"> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only" id="ca-talk-sticky-header" tabindex="-1" data-event-name="talk-sticky-header"><span class="vector-icon mw-ui-icon-speechBubbles mw-ui-icon-wikimedia-speechBubbles"></span> <span></span> </a> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only" id="ca-subject-sticky-header" tabindex="-1" data-event-name="subject-sticky-header"><span class="vector-icon mw-ui-icon-article mw-ui-icon-wikimedia-article"></span> <span></span> </a> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only" id="ca-history-sticky-header" tabindex="-1" data-event-name="history-sticky-header"><span class="vector-icon mw-ui-icon-wikimedia-history mw-ui-icon-wikimedia-wikimedia-history"></span> <span></span> </a> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only mw-watchlink" id="ca-watchstar-sticky-header" tabindex="-1" data-event-name="watch-sticky-header"><span class="vector-icon mw-ui-icon-wikimedia-star mw-ui-icon-wikimedia-wikimedia-star"></span> <span></span> </a> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only" id="ca-edit-sticky-header" tabindex="-1" data-event-name="wikitext-edit-sticky-header"><span class="vector-icon mw-ui-icon-wikimedia-wikiText mw-ui-icon-wikimedia-wikimedia-wikiText"></span> <span></span> </a> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only" id="ca-ve-edit-sticky-header" tabindex="-1" data-event-name="ve-edit-sticky-header"><span class="vector-icon mw-ui-icon-wikimedia-edit mw-ui-icon-wikimedia-wikimedia-edit"></span> <span></span> </a> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only" id="ca-viewsource-sticky-header" tabindex="-1" data-event-name="ve-edit-protected-sticky-header"><span class="vector-icon mw-ui-icon-wikimedia-editLock mw-ui-icon-wikimedia-wikimedia-editLock"></span> <span></span> </a> </div> <div class="vector-sticky-header-buttons"> <button class="cdx-button cdx-button--weight-quiet mw-interlanguage-selector" id="p-lang-btn-sticky-header" tabindex="-1" data-event-name="ui.dropdown-p-lang-btn-sticky-header"><span class="vector-icon mw-ui-icon-wikimedia-language mw-ui-icon-wikimedia-wikimedia-language"></span> <span>1 language</span> </button> <a href="#" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive" id="ca-addsection-sticky-header" tabindex="-1" data-event-name="addsection-sticky-header"><span class="vector-icon mw-ui-icon-speechBubbleAdd-progressive mw-ui-icon-wikimedia-speechBubbleAdd-progressive"></span> <span>Add topic</span> </a> </div> <div class="vector-sticky-header-icon-end"> <div class="vector-user-links"> </div> </div> </div> </div> </div> <div class="vector-settings" id="p-dock-bottom"> <ul></ul> </div><script>(RLQ=window.RLQ||[]).push(function(){mw.config.set({"wgHostname":"mw-web.codfw.main-66f8d669c9-sht9b","wgBackendResponseTime":161,"wgPageParseReport":{"limitreport":{"cputime":"0.458","walltime":"0.565","ppvisitednodes":{"value":2194,"limit":1000000},"postexpandincludesize":{"value":142161,"limit":2097152},"templateargumentsize":{"value":1708,"limit":2097152},"expansiondepth":{"value":11,"limit":100},"expensivefunctioncount":{"value":1,"limit":500},"unstrip-depth":{"value":1,"limit":20},"unstrip-size":{"value":45636,"limit":5000000},"entityaccesscount":{"value":1,"limit":400},"timingprofile":["100.00% 468.563 1 -total"," 30.84% 144.504 1 Template:Reflist"," 30.68% 143.777 7 Template:Navbox"," 25.16% 117.891 1 Template:Cytokine_receptors"," 24.64% 115.466 4 Template:Cite_journal"," 22.38% 104.870 3 Template:Infobox_protein"," 19.22% 90.045 5 Template:Infobox"," 15.49% 72.601 1 Template:Short_description"," 7.85% 36.779 2 Template:Pagetype"," 5.24% 24.566 9 Template:Main_other"]},"scribunto":{"limitreport-timeusage":{"value":"0.282","limit":"10.000"},"limitreport-memusage":{"value":4643464,"limit":52428800}},"cachereport":{"origin":"mw-web.codfw.main-84b999ff94-z9hh2","timestamp":"20250204112627","ttl":2592000,"transientcontent":false}}});});</script> <script type="application/ld+json">{"@context":"https:\/\/schema.org","@type":"Article","name":"Interleukin-15 receptor","url":"https:\/\/en.wikipedia.org\/wiki\/Interleukin-15_receptor","sameAs":"http:\/\/www.wikidata.org\/entity\/Q27312158","mainEntity":"http:\/\/www.wikidata.org\/entity\/Q27312158","author":{"@type":"Organization","name":"Contributors to Wikimedia projects"},"publisher":{"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":{"@type":"ImageObject","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-hor-googpub.png"}},"datePublished":"2008-02-09T09:19:36Z","dateModified":"2024-04-29T06:50:07Z","image":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/a\/a1\/Protein_IL15RA_PDB_2ers.png"}</script> </body> </html>