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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="mykSgxva2u-ciiSGHbcw_zPpPJ5TP2ylRDfMCvoCIP9Ot255ZFCEWAjcXAF2oOk4iouSPsR9XyvE6Xarez_BeA" /> <meta name="citation_title" content="Preterm and term neonates transplacentally acquire IgG antibodies specific to LPS from Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa" /> <meta name="citation_publication_date" content="2011/01/01" /> <meta name="citation_journal_title" content="FEMS immunology and medical microbiology" /> <meta name="citation_author" content="Ana Celi Lessa" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/65379597/Preterm_and_term_neonates_transplacentally_acquire_IgG_antibodies_specific_to_LPS_from_Klebsiella_pneumoniae_Escherichia_coli_and_Pseudomonas_aeruginosa" /> <meta name="twitter:title" content="Preterm and term neonates transplacentally acquire IgG antibodies specific to LPS from Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa" /> <meta name="twitter:description" content="High incidences of Gram-negative bacteria are found in neonatal nosocomial infections. Our aim was to investigate placental transmission of immunoglobulin G (IgG) reactive with lipopolysaccharide from Klebsiella pneumoniae, Pseudomonas aeruginosa and" /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/65379597/Preterm_and_term_neonates_transplacentally_acquire_IgG_antibodies_specific_to_LPS_from_Klebsiella_pneumoniae_Escherichia_coli_and_Pseudomonas_aeruginosa" /> <meta property="og:title" content="Preterm and term neonates transplacentally acquire IgG antibodies specific to LPS from Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="High incidences of Gram-negative bacteria are found in neonatal nosocomial infections. Our aim was to investigate placental transmission of immunoglobulin G (IgG) reactive with lipopolysaccharide from Klebsiella pneumoniae, Pseudomonas aeruginosa and" /> <meta property="article:author" content="https://independent.academia.edu/AnaCeliLessa" /> <meta name="description" content="High incidences of Gram-negative bacteria are found in neonatal nosocomial infections. Our aim was to investigate placental transmission of immunoglobulin G (IgG) reactive with lipopolysaccharide from Klebsiella pneumoniae, Pseudomonas aeruginosa and" /> <title>(PDF) Transplacental IgG Acquisition in Neonates</title> <link rel="canonical" href="https://www.academia.edu/65379597/Preterm_and_term_neonates_transplacentally_acquire_IgG_antibodies_specific_to_LPS_from_Klebsiella_pneumoniae_Escherichia_coli_and_Pseudomonas_aeruginosa" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = 'b092bf3a3df71cf13feee7c143e83a57eb6b94fb'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1739839498000); window.Aedu.timeDifference = new Date().getTime() - 1739839498000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"High incidences of Gram-negative bacteria are found in neonatal nosocomial infections. Our aim was to investigate placental transmission of immunoglobulin G (IgG) reactive with lipopolysaccharide from Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli O111, O6 and O26. The total and lipopolysaccharide-specific IgM and IgG were determined in 11 maternal/umbilical-cord sera aged ≤33 weeks (GI); 21 aged \u0026amp;amp;gt;33 and \u0026amp;amp;lt;37 weeks (GII); and 32 term newborns (GIII). The total and lipopolysaccharide-specific IgM concentrations were equivalent in maternal sera. The total IgG concentrations were equivalent in maternal and newborn sera, with the exception of GIII newborns as compared with their mothers (P\u0026amp;amp;lt;0.0001) and with neonates from GI and GII (P\u0026amp;amp;lt;0.05). Lipopolysaccharide-specific IgG concentrations were lower in GI neonates than in their mothers (P\u0026amp;amp;lt;0.01) and lower in GII (P\u0026amp;amp;lt;0.05). Lower lipopolysaccharide-specific IgG levels were observed among neonates only for...","author":[{"@context":"https://schema.org","@type":"Person","name":"Ana Celi Lessa","url":"https://independent.academia.edu/AnaCeliLessa"}],"contributor":[],"dateCreated":"2021-12-21","dateModified":"2025-01-31","datePublished":"2011-01-01","headline":"Preterm and term neonates transplacentally acquire IgG antibodies specific to LPS from Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa","image":"https://attachments.academia-assets.com/77001943/thumbnails/1.jpg","inLanguage":"en","keywords":["Immunology","Medical Microbiology","Biology","Adolescent","Medicine","Escherichia coli","Young Adult","Pseudomonas aeruginosa","Newborn Infant","Lipopolysaccharides","Pseudomonas Aeruginosa","Premature Birth","immunoglobulin G","Klebsiella pneumoniae","immunoglobulin M","Cardiovascular medicine and haematology"],"publication":"FEMS immunology and medical microbiology","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}],"thumbnailUrl":"https://attachments.academia-assets.com/77001943/thumbnails/1.jpg","url":"https://www.academia.edu/65379597/Preterm_and_term_neonates_transplacentally_acquire_IgG_antibodies_specific_to_LPS_from_Klebsiella_pneumoniae_Escherichia_coli_and_Pseudomonas_aeruginosa"}</script><style type="text/css">@media(max-width: 567px){:root{--token-mode: Rebrand;--dropshadow: 0 2px 4px 0 #22223340;--primary-brand: #0645b1;--error-dark: #b60000;--success-dark: #05b01c;--inactive-fill: #ebebee;--hover: #0c3b8d;--pressed: #082f75;--button-primary-fill-inactive: #ebebee;--button-primary-fill: #0645b1;--button-primary-text: #ffffff;--button-primary-fill-hover: #0c3b8d;--button-primary-fill-press: #082f75;--button-primary-icon: #ffffff;--button-primary-fill-inverse: 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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F65379597%2FPreterm_and_term_neonates_transplacentally_acquire_IgG_antibodies_specific_to_LPS_from_Klebsiella_pneumoniae_Escherichia_coli_and_Pseudomonas_aeruginosa%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":77001943,"identifier":"Attachment_77001943","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":65379597,"created_at":"2021-12-21T16:29:04.152-08:00","from_world_paper_id":188409262,"updated_at":"2025-01-31T18:25:00.655-08:00","_data":{"abstract":"High incidences of Gram-negative bacteria are found in neonatal nosocomial infections. Our aim was to investigate placental transmission of immunoglobulin G (IgG) reactive with lipopolysaccharide from Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli O111, O6 and O26. The total and lipopolysaccharide-specific IgM and IgG were determined in 11 maternal/umbilical-cord sera aged ≤33 weeks (GI); 21 aged \u0026gt;33 and \u0026lt;37 weeks (GII); and 32 term newborns (GIII). The total and lipopolysaccharide-specific IgM concentrations were equivalent in maternal sera. The total IgG concentrations were equivalent in maternal and newborn sera, with the exception of GIII newborns as compared with their mothers (P\u0026lt;0.0001) and with neonates from GI and GII (P\u0026lt;0.05). Lipopolysaccharide-specific IgG concentrations were lower in GI neonates than in their mothers (P\u0026lt;0.01) and lower in GII (P\u0026lt;0.05). Lower lipopolysaccharide-specific IgG levels were observed among neonates only for...","ai_title_tag":"Transplacental IgG Acquisition in Neonates","publication_date":"2011,,","publication_name":"FEMS immunology and medical microbiology"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Preterm and term neonates transplacentally acquire IgG antibodies specific to LPS from Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [84105089]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":77001943,"attachmentType":"pdf"}"><img alt="First page of “Preterm and term neonates transplacentally acquire IgG antibodies specific to LPS from Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/77001943/mini_magick20211221-27476-1q9ejim.png?1640133058" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Preterm and term neonates transplacentally acquire IgG antibodies specific to LPS from Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="84105089" href="https://independent.academia.edu/AnaCeliLessa"><img alt="Profile image of Ana Celi Lessa" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Ana Celi Lessa</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2011, FEMS immunology and medical microbiology</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">8 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 65379597; 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if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">High incidences of Gram-negative bacteria are found in neonatal nosocomial infections. Our aim was to investigate placental transmission of immunoglobulin G (IgG) reactive with lipopolysaccharide from Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli O111, O6 and O26. The total and lipopolysaccharide-specific IgM and IgG were determined in 11 maternal/umbilical-cord sera aged ≤33 weeks (GI); 21 aged &gt;33 and &lt;37 weeks (GII); and 32 term newborns (GIII). The total and lipopolysaccharide-specific IgM concentrations were equivalent in maternal sera. The total IgG concentrations were equivalent in maternal and newborn sera, with the exception of GIII newborns as compared with their mothers (P&lt;0.0001) and with neonates from GI and GII (P&lt;0.05). Lipopolysaccharide-specific IgG concentrations were lower in GI neonates than in their mothers (P&lt;0.01) and lower in GII (P&lt;0.05). Lower lipopolysaccharide-specific IgG levels were observed among neonates only for...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":77001943,"attachmentType":"pdf","workUrl":"https://www.academia.edu/65379597/Preterm_and_term_neonates_transplacentally_acquire_IgG_antibodies_specific_to_LPS_from_Klebsiella_pneumoniae_Escherichia_coli_and_Pseudomonas_aeruginosa"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":77001943,"attachmentType":"pdf","workUrl":"https://www.academia.edu/65379597/Preterm_and_term_neonates_transplacentally_acquire_IgG_antibodies_specific_to_LPS_from_Klebsiella_pneumoniae_Escherichia_coli_and_Pseudomonas_aeruginosa"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-premium-marketing"></div></div><div class="ds-signup-banner ds-signup-banner-premium-marketing"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="premium-banner-content"><div class="left"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><span>Get access to the world's latest research</span></div><div class="right"><div class="card free"><div class="header">Free</div><div class="feature-list"><div class="feature"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">check</span><span>Download one paper at a time</span></div><div class="feature"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">check</span><span>Save papers to bookmarks</span></div><div class="feature"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">check</span><span>Basic search</span></div></div><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--small ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"premium-banner-desktop-free"}">Sign up for free</button></div><div class="card premium"><div class="pill">Recommended</div><div class="header premium">Premium</div><div class="feature-list"><div class="feature"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">check</span><span>Get highly curated PDF packages</span></div><div class="feature"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">check</span><span>Track your impact with Mentions</span></div><div class="feature"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">check</span><span>Access advanced search filters</span></div><div class="feature"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">check</span><span>Support Academia’s mission</span></div><div class="feature"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">check</span><span>Create your personal website</span></div></div><button class="ds2-5-button ds2-5-button--small ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"premium-banner-desktop-upgrade","submitText":"Try Premium for $1"}">Try Premium for $1</button></div></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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Specific protection of the pups was also achieved by immunizing the pregnant rats with purified 018 lipopolysaccharide. We suppose that most human newborns that are colonized by potentially invasive Kl E. coli are protected by the transplacental transfer of anti-lipopolysaccharide immunoglobulin G, and we suggest that treatment with such antibodies might in the future be considered a therapeutic option. Rat serum from 1-week-old animals had only about one-third of the complement hemolytic activity of adult rat serum. This low level of hemolytic activity correlated with a relatively poor bactericidal activity in antibody-dependent and antibody-independent bactericidal in vitro assays. Monoclonal anti-018 immunoglobulin M, although protective in vivo and bactericidal when added to adult rat serum, only poorly inhibited the multiplication of 018:K1 cells in serum from 1-week-old rats. This suggests that other elements of host defense besides complement participate in antibody-mediated in vivo protection. Escherichia coli strains of the Kl capsular serotype rep- resent about 80% of all E. coli bacteria isolated from cases of meningitis in newborns (25, 26, 29). Most of the Kl isolates belong to a limited spectrum of O-lipopolysaccharide (LPS) antigen types. Data have been presented elsewhere showing that pyelonephritis and meningitis in newborns can be dif- ferentially associated with Kl bacteria of different 0 serotypes (14, 24). Here we concentrate on their virulence with regard to newborn meningitis. 01:K1, 07:K1, and 018:K1 bacteria have all been isolated from fecal samples of healthy individuals and from newborns with meningitis. However, the relative frequency of isolation of these bacteria differs almost eightfold between these two sources, and 01:K1 bacteria were therefore concluded to be relatively avirulent with regard to neonatal meningitis compared to the two other bacterial groups (24). Distinct differences were observed when these groups of bacteria were tested for the ability to cause bacteremia after colonizing the gut of 5-to 7-day-old rats (24). All of these Kl strains colonized the gut and translocated to the mesenteric lymph nodes with comparable efficiency.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Antibodies to O-antigen of lipopolysaccharide are protective against neonatal infection with Escherichia coli K1","attachmentId":120834116,"attachmentType":"pdf","work_url":"https://www.academia.edu/127042866/Antibodies_to_O_antigen_of_lipopolysaccharide_are_protective_against_neonatal_infection_with_Escherichia_coli_K1","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/127042866/Antibodies_to_O_antigen_of_lipopolysaccharide_are_protective_against_neonatal_infection_with_Escherichia_coli_K1"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="13653050" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13653050/Placental_transfer_of_IgG_and_IgG_subclass_antibodies_anti_purified_Escherichia_coli_LPS_O16_O6_and_O111">Placental transfer of IgG and IgG subclass antibodies anti-purified Escherichia coli LPS O16, O6 and O111</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32808009" href="https://ufmt.academia.edu/OTakano">O. Takano</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Scandinavian journal of immunology, 1998</p><p class="ds-related-work--abstract ds2-5-body-sm">We evaluated 22 paired maternal and cord sera regarding the presence of IgG and IgG subclasses against purified Escherichia coli LPS O6, O16 and O111 employing ELISA for titre and avidity analysis, isoelectric focusing associated with affinity-blotting for spectrotypic analysis, and the Western-blotting technique for recognition of the various bands in lipopolysaccharide (LPS). Levels of anti-LPS IgG antibodies in cord sera were equivalent to their respective maternal sera, showing a significant correlation (P &lt; 0.0001). IgG1 antibody levels were higher in cord sera than in maternal sera (P &lt; 0.005 for anti-O111, P &lt; 0.05 for anti-O16 and P &lt; 0.02 for anti-O6). Cord IgG2 antibody levels were not different from the maternal levels (P &gt; 0.1). The levels of IgG3 and IgG4 were undetectable. The avidity of anti-O6 and anti-O111 IgG in 10 cord sera showed an extremely significant correlation with maternal antibody avidity (P &lt; 0.0001). Identical patterns of recognition w...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Placental transfer of IgG and IgG subclass antibodies anti-purified Escherichia coli LPS O16, O6 and O111","attachmentId":45103295,"attachmentType":"pdf","work_url":"https://www.academia.edu/13653050/Placental_transfer_of_IgG_and_IgG_subclass_antibodies_anti_purified_Escherichia_coli_LPS_O16_O6_and_O111","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13653050/Placental_transfer_of_IgG_and_IgG_subclass_antibodies_anti_purified_Escherichia_coli_LPS_O16_O6_and_O111"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="105560716" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/105560716/Current_status_of_intravenous_immunoglobuiin_in_preventing_or_treating_neonatal_bacterial_infections">Current status of intravenous immunoglobuiin in preventing or treating neonatal bacterial infections</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36158955" href="https://independent.academia.edu/LeonardWeisman">Leonard Weisman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical Reviews in Allergy, 1992</p><p class="ds-related-work--abstract ds2-5-body-sm">Bacterial infections continue to be an important problem for neonates throughout the world. Since newborn babies acquire immunoglobulin (IgG) transplacentally from their mothers in the latter part of gestation, premature infants (<32-34 Wk gestation) have decreased levels of serum IgG (1,2). The antibodies acquired transplacentally are also limited to the mother's previous exposure to specific pathogens~ Therefore, newborns (especially preterms) may have both a qualitative and quantitative immunoglobulin deficiency. Opsonic antibody is important for immunity against bacteria with polysaccharide capsules (Streptococcus agalactiae, Streptococcus pneumoniae, HemophiIus influenzae, Escherichia coli) and intravenous Lmmunoglobulin (MG) has been shown to contain opsonic antibody for several of these bacterial pathogens (3, 6). Several studies over the last 25 yr in newborn babies have suggested that immunoglobulin therapy might enhance neonatal immunity against bacterial pathogens. In 1963 immune serum globulin (ISG) was given intramuscularly every 4 wk to premature infants and resulted in fewer manor il~esses (7). However, it was Concluded</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Current status of intravenous immunoglobuiin in preventing or treating neonatal bacterial infections","attachmentId":104980295,"attachmentType":"pdf","work_url":"https://www.academia.edu/105560716/Current_status_of_intravenous_immunoglobuiin_in_preventing_or_treating_neonatal_bacterial_infections","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/105560716/Current_status_of_intravenous_immunoglobuiin_in_preventing_or_treating_neonatal_bacterial_infections"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="117497725" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/117497725/Umbilical_Cord_Blood_IgA_Levels_and_Bacterial_Profile_in_Preterm_Neonates_Born_with_Maternal_Risk_Factors_for_Early_Onset_Neonatal_Sepsis_Authors_Reply">Umbilical Cord Blood IgA Levels and Bacterial Profile in Preterm Neonates Born with Maternal Risk Factors for Early-Onset Neonatal Sepsis: Authors’ Reply</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="151076445" href="https://independent.academia.edu/kajaljain54">kajal jain</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Indian Journal of Pediatrics</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Umbilical Cord Blood IgA Levels and Bacterial Profile in Preterm Neonates Born with Maternal Risk Factors for Early-Onset Neonatal Sepsis: Authors’ Reply","attachmentId":113338711,"attachmentType":"pdf","work_url":"https://www.academia.edu/117497725/Umbilical_Cord_Blood_IgA_Levels_and_Bacterial_Profile_in_Preterm_Neonates_Born_with_Maternal_Risk_Factors_for_Early_Onset_Neonatal_Sepsis_Authors_Reply","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/117497725/Umbilical_Cord_Blood_IgA_Levels_and_Bacterial_Profile_in_Preterm_Neonates_Born_with_Maternal_Risk_Factors_for_Early_Onset_Neonatal_Sepsis_Authors_Reply"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="123445248" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/123445248/Maternal_and_neonatal_IgG_against_Klebsiella_pneumoniae_are_associated_with_broad_protection_from_neonatal_sepsis_a_case_control_study_of_hospitalized_neonates_in_Botswana">Maternal and neonatal IgG against Klebsiella pneumoniae are associated with broad protection from neonatal sepsis: a case-control study of hospitalized neonates in Botswana</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="91973879" href="https://independent.academia.edu/NametsoLekwape">Nametso Lekwape</a></div><p class="ds-related-work--metadata ds2-5-body-xs">medRxiv (Cold Spring Harbor Laboratory), 2024</p><p class="ds-related-work--abstract ds2-5-body-sm">Sepsis is the leading postnatal cause of neonatal mortality worldwide. Globally Klebsiella pneumoniae is the leading cause of sepsis in hospitalized neonates. This study reports development and evaluation of ELISA for anti-Klebsiella IgG using dried blood spot samples and evaluates the association of anti-Klebsiella IgG (anti-Kleb IgG) antibodies in maternal and 26 neonatal samples and the risk of neonatal sepsis. Neonates and their mothers were enrolled at 0-27 96 hours of life in the neonatal unit of a tertiary referral hospital in Gaborone, Botswana and 28 followed until death or discharge to assess for episodes of blood culture-confirmed neonatal sepsis. Neonates with sepsis had significantly lower levels of Kleb-IgG compared to neonates who did not develop sepsis (Mann-Whitney U, p=0.012). Similarly, samples from mothers of neonates who developed sepsis tended to have less Kleb-IgG compared to mothers of controls (p=0.06). The 32 inverse correlation between Kleb-IgG levels and all-cause bacteremia suggests that maternal Kleb-33 IgG is broadly protective through cross-reactivity with common bacterial epitopes. These data 34 support the continued use of immunoglobulin assays using DBS samples to explore the role of 35 passive immunity on neonatal sepsis risk and reaffirm the critical need for research supporting the 36 development of maternal vaccines for neonatal sepsis.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Maternal and neonatal IgG against Klebsiella pneumoniae are associated with broad protection from neonatal sepsis: a case-control study of hospitalized neonates in Botswana","attachmentId":117873870,"attachmentType":"pdf","work_url":"https://www.academia.edu/123445248/Maternal_and_neonatal_IgG_against_Klebsiella_pneumoniae_are_associated_with_broad_protection_from_neonatal_sepsis_a_case_control_study_of_hospitalized_neonates_in_Botswana","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/123445248/Maternal_and_neonatal_IgG_against_Klebsiella_pneumoniae_are_associated_with_broad_protection_from_neonatal_sepsis_a_case_control_study_of_hospitalized_neonates_in_Botswana"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="121017681" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/121017681/Standard_Versus_Hyperimmune_Intravenous_Immunoglobulin_in_Preventing_or_Treating_Neonatal_Bacterial_Infections">Standard Versus Hyperimmune Intravenous Immunoglobulin in Preventing or Treating Neonatal Bacterial Infections</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34877209" href="https://trick-computer.academia.edu/DavidCruess">David Cruess</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinics in Perinatology, 1993</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Standard Versus Hyperimmune Intravenous Immunoglobulin in Preventing or Treating Neonatal Bacterial Infections","attachmentId":115998608,"attachmentType":"pdf","work_url":"https://www.academia.edu/121017681/Standard_Versus_Hyperimmune_Intravenous_Immunoglobulin_in_Preventing_or_Treating_Neonatal_Bacterial_Infections","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/121017681/Standard_Versus_Hyperimmune_Intravenous_Immunoglobulin_in_Preventing_or_Treating_Neonatal_Bacterial_Infections"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="14237023" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14237023/Protective_activity_of_the_antilipopolysaccharide_antibodies_from_human_cord_serum">Protective activity of the antilipopolysaccharide antibodies from human cord serum</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33209420" href="https://independent.academia.edu/SilviaMassironi">Silvia Massironi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Fems Immunology and Medical Microbiology, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">We evaluated the ability of human maternal and cord serum antibodies to protect mice challenged with live Escherichia coli serotype O6:K2ac (E. coli O6). Mice received paired maternal or cord serum pools before a challenge with E. coli O6 to evaluate the mortality rate. All the pools were able to protect the animals challenged with bacteria except the test group from paired maternal and cord sera from preterm neonates containing less than 1.0 mg L À1 immunoglobulin G antibody levels. In liver, spleen and mesenteric lymph nodes from the control group (phosphate-buffered saline), more than 10 2 CFU mL À1 bacteria were found at 30 min and more than 10 5 CFU mL À1 after 120 min. The test group showed lower bacterial counts in the organs, and no bacteria in the mesenteric lymph nodes during the evaluated period. Tumor necrosis factor alpha and interleukin 6 were undetectable in serum from animals pretreated with paired maternal and cord serum pools from full-term neonates and pools from preterm neonates containing high antibody and avidity levels. Our findings suggest that placental transfer of antilipopolysaccharide O6 immunoglobulin G antibodies to neonates has a high capacity to prevent lethal infection with E. coli O6 in a mouse protection model and that the degree of protection is determined by the concentration and avidity of these IgG antibodies.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Protective activity of the antilipopolysaccharide antibodies from human cord serum","attachmentId":44419782,"attachmentType":"pdf","work_url":"https://www.academia.edu/14237023/Protective_activity_of_the_antilipopolysaccharide_antibodies_from_human_cord_serum","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/14237023/Protective_activity_of_the_antilipopolysaccharide_antibodies_from_human_cord_serum"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="13563247" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13563247/Placental_Transfer_of_IgG_and_IgG_Subclass_Antibodies_Anti_Purified_Escherichia_coli_LPS_016_06_and_0111">Placental Transfer of IgG and IgG Subclass Antibodies Anti-Purified Escherichia coli LPS 016, 06 and 0111</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32746507" href="https://unifesp.academia.edu/BeatrizTavaresCostaCarvalho">Beatriz Tavares Costa Carvalho</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32796399" href="https://independent.academia.edu/VVieira1">V. Vieira</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32808009" href="https://ufmt.academia.edu/OTakano">O. Takano</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Nagao AT, Martinez CC, Vieira VS, Takano OA, Costa-Carvalho BT, Carneiro-Sampaio MMS. Placental Transfer of IgG and IgG Subclass Antibodies Anti-Purified Escherichia coli LPS O16, O6 and O111. Scand J Immunol 1998;47:609-614 We evaluated 22 paired maternal and cord sera regarding the presence of IgG and IgG subclasses against purified Escherichia coli LPS O6, O16 and O111 employing ELISA for titre and avidity analysis, isoelectric focusing associated with affinity-blotting for spectrotypic analysis, and the Western-blotting technique for recognition of the various bands in lipopolysaccharide (LPS). Levels of anti-LPS IgG antibodies in cord sera were equivalent to their respective maternal sera, showing a significant correlation (P < 0.0001). IgG1 antibody levels were higher in cord sera than in maternal sera (P < 0.005 for anti-O111, P < 0.05 for anti-O16 and P < 0.02 for anti-O6). Cord IgG2 antibody levels were not different from the maternal levels (P > 0.1). The levels of IgG3 and IgG4 were undetectable. The avidity of anti-O6 and anti-O111 IgG in 10 cord sera showed an extremely significant correlation with maternal antibody avidity (P < 0.0001). Identical patterns of recognition were found in the paired samples analysed by Western blotting. Most of the serum samples recognized the O-repetitive chains and also the region corresponding to core and lipid A. Although the antibody spectrotypes varied among individuals, paired cord and maternal serum samples showed identical patterns. Our findings suggest the occurrence of placental transfer of IgG antibodies against LPS O6, O16 and O111, mainly involving the IgG1 or IgG2 subclasses.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Placental Transfer of IgG and IgG Subclass Antibodies Anti-Purified Escherichia coli LPS 016, 06 and 0111","attachmentId":45212144,"attachmentType":"pdf","work_url":"https://www.academia.edu/13563247/Placental_Transfer_of_IgG_and_IgG_Subclass_Antibodies_Anti_Purified_Escherichia_coli_LPS_016_06_and_0111","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13563247/Placental_Transfer_of_IgG_and_IgG_Subclass_Antibodies_Anti_Purified_Escherichia_coli_LPS_016_06_and_0111"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="111139294" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/111139294/Induction_of_bacteremia_in_newborn_rats_by_Escherichia_coli_K1_is_correlated_with_only_certain_O_lipopolysaccharide_antigen_types">Induction of bacteremia in newborn rats by Escherichia coli K1 is correlated with only certain O (lipopolysaccharide) antigen types</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39122500" href="https://independent.academia.edu/GerdPluschke">Gerd Pluschke</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Infection and Immunity, 1983</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Induction of bacteremia in newborn rats by Escherichia coli K1 is correlated with only certain O (lipopolysaccharide) antigen types","attachmentId":108749309,"attachmentType":"pdf","work_url":"https://www.academia.edu/111139294/Induction_of_bacteremia_in_newborn_rats_by_Escherichia_coli_K1_is_correlated_with_only_certain_O_lipopolysaccharide_antigen_types","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/111139294/Induction_of_bacteremia_in_newborn_rats_by_Escherichia_coli_K1_is_correlated_with_only_certain_O_lipopolysaccharide_antigen_types"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="84691641" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/84691641/Analysis_of_colostrum_IgA_against_bacteria_involved_in_neonatal_infections">Analysis of colostrum IgA against bacteria involved in neonatal infections</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="178219433" href="https://independent.academia.edu/ElizabethMoreiraDias">Elizabeth Moreira Dias</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Einstein (Sao Paulo, Brazil)</p><p class="ds-related-work--abstract ds2-5-body-sm">To describe e compare the specificity of IgA antibodies against bacteria extract of Klebsiella pneumoniae , Staphylococcus aureus , Escherichia coli , and Salmonella enteritidis . Colostrum samples were aseptically collected in the first 12 hours after C-section delivery. The specificity of IgA against bacteria extracts was analyzed by the Western blot. The findings showed proteins of high molecular weight frequently detectable in the samples. S. aureus was the most frequently found bacterium in the samples (p&lt;0.05). Approximately 93.8, 56.3, 62.5 and 60.4% of samples presented IgA reactive to S. aureus , K. pneumoniae , S. enteritidis, and E. coli, respectively. Roughly 40% of samples showed no IgA reactive to K. pneumoniae, S. enteritidis and E. coli . Clinical evidence of the importance of breastfeeding for the immune protection of neonates was consistent with the observed immunological findings, since most samples showed IgA reactive against the species tested. The applicatio...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Analysis of colostrum IgA against bacteria involved in neonatal infections","attachmentId":89625991,"attachmentType":"pdf","work_url":"https://www.academia.edu/84691641/Analysis_of_colostrum_IgA_against_bacteria_involved_in_neonatal_infections","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/84691641/Analysis_of_colostrum_IgA_against_bacteria_involved_in_neonatal_infections"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":77001943,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":77001943,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_77001943" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="30523496" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/30523496/Immunoglobulin_secretion_by_the_normal_and_the_infected_newborn_infant">Immunoglobulin secretion by the normal and the infected newborn infant</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="58181376" href="https://independent.academia.edu/RhondaAshby">Rhonda Ashby</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Pediatrics, 1993</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunoglobulin secretion by the normal and the infected newborn infant","attachmentId":50967829,"attachmentType":"pdf","work_url":"https://www.academia.edu/30523496/Immunoglobulin_secretion_by_the_normal_and_the_infected_newborn_infant","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/30523496/Immunoglobulin_secretion_by_the_normal_and_the_infected_newborn_infant"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="111955284" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/111955284/Neonatal_infections_I_Maternal_and_cord_serum_IgG_levels_in_relation_to_gestation_and_intrauterine_growth">Neonatal infections: I—Maternal and cord serum IgG levels in relation to gestation and intrauterine growth</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="284072471" href="https://independent.academia.edu/PratibhaNarang2">Pratibha Narang</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Indian Journal of Pediatrics, 1984</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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data-author-id="182819952" href="https://independent.academia.edu/JudeOkoyeh">Jude Okoyeh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Pathogens</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Bacteriology and Its Virulence Factors in Neonatal Infections: Threats to Child Survival Strategies","attachmentId":82537468,"attachmentType":"pdf","work_url":"https://www.academia.edu/74354586/The_Bacteriology_and_Its_Virulence_Factors_in_Neonatal_Infections_Threats_to_Child_Survival_Strategies","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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href="https://www.academia.edu/124656829/Gut_acquisition_of_Extended_spectrum_%CE%B2_lactamases_producing_Klebsiella_pneumoniae_in_preterm_neonates_Critical_role_of_enteral_feeding_and_endotracheal_tubes_in_the_neonatal_intensive_care_unit_NICU_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="19" data-entity-id="23003422" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/23003422/Placental_transfer_of_immunoglobulin_G_subclasses">Placental transfer of immunoglobulin G subclasses</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3773417" href="https://independent.academia.edu/YDanon">Yehuda 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