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class="et_close_search_field"></span> </div> </div> </header>  <div id="et-main-area"> <div id="main-content"> <div class="container"> <div id="content-area" class="clearfix"> <div id="left-area"> <article id="post-8744" class="et_pb_post post-8744 post type-post status-publish format-standard has-post-thumbnail hentry category-technology tag-amr tag-animal-health tag-cattle tag-farm tag-funding tag-global-health tag-grant tag-infectious-disease tag-investment tag-one-health tag-research tag-technology tag-vaccine tag-viral-vector"> <div class="et_post_meta_wrapper"> <h1 class="entry-title">The Vaccine Group and APHA secure animal vaccine grant</h1> <p class="post-meta"> by <span class="author vcard"><a href="https://vaccinenation.org/author/charlotte-kilpatrick/" title="Posts by Charlotte Kilpatrick" rel="author">Charlotte Kilpatrick</a></span> | <span class="published">Oct 18, 2024</span> | <a href="https://vaccinenation.org/category/technology/" rel="category tag">Technology</a> | <span class="comments-number"><a href="https://vaccinenation.org/technology/the-vaccine-group-and-apha-secure-animal-vaccine-grant/#respond">0 comments</a></span></p><img data-src="https://vaccinenation.org/wp-content/uploads/2024/10/Heading-2024-10-18T140704.886-1080x675.png?crop=1" alt="" width="1080" height="675" data-srcset="https://vaccinenation.org/wp-content/uploads/2024/10/Heading-2024-10-18T140704.886-1080x675.png?crop=1 1080w, https://vaccinenation.org/wp-content/uploads/2024/10/Heading-2024-10-18T140704.886-980x653.png 980w, https://vaccinenation.org/wp-content/uploads/2024/10/Heading-2024-10-18T140704.886-480x320.png 480w" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 1080px; --smush-placeholder-aspect-ratio: 1080/675;" /><noscript><img src="https://vaccinenation.org/wp-content/uploads/2024/10/Heading-2024-10-18T140704.886-1080x675.png?crop=1" alt="" class="" width="1080" height="675" srcset="https://vaccinenation.org/wp-content/uploads/2024/10/Heading-2024-10-18T140704.886-1080x675.png?crop=1 1080w, https://vaccinenation.org/wp-content/uploads/2024/10/Heading-2024-10-18T140704.886-980x653.png 980w, https://vaccinenation.org/wp-content/uploads/2024/10/Heading-2024-10-18T140704.886-480x320.png 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" /></noscript> </div> <div class="entry-content"> <p><span data-contrast="auto">In October 2024 the Animal and Plant Health Agency (APHA) and The Vaccine Group (TVG) <a href="https://thevaccinegroup.com/innovate-uk-smart-grant-awarded-to-the-vaccine-group-apha-for-cattle-vaccine-platform-development/" target="_blank" rel="noopener">announced</a> that Innovate UK has awarded them a Smart grant in excess of £400,000 to advance a novel viral vector platform. In a project lasting 19 months, the two organisations will use technology developed by TVG scientists in candidate vaccines for two “important diseases in cattle”: bovine respiratory syncytial virus (BRSV) and lumpy skin disease (LSD). The project will continue previous research, which identified potential vaccine candidates; it is supported by the World Reference Laboratory for Non-Vesicular Diseases at The Pirbright Institute, determining how the candidates can produce an adequate serological response in animals and protect cattle.</span><span data-ccp-props="{}"> </span></p> <h5><span data-contrast="auto">BRSV and LSD</span><span data-ccp-props="{}"> </span></h5> <p><span data-contrast="auto">Bovine respiratory syncytial virus (BRSV) is the leading viral cause of respiratory illness in young calves in the UK. It affects around 1.9 million calves each year, costing approximately £54 million. It is “prevalent worldwide” and poses a “substantial economic burden” on beef and dairy producers. In the past 10 years, lumpy skin disease (LSD) has spread “dramatically” beyond former natural enzootic geographies in Africa and the Middle East to cause “severe disease” in other regions. </span><span data-ccp-props="{}"> </span></p> <p><span data-contrast="auto">Both diseases have “broad global prevalence”, and BRSV particularly affects intensively reared cattle. Currently available commercial vaccines for BRSV do not prevent shedding and are restricted from use in young calves by maternal immunity. There are no DIVA (differentiating infected from vaccinated animals) vaccines available for LSD, so use is limited to areas where serosurveillance and eradication programmes are in place. </span><span data-ccp-props="{}"> </span></p> <h5><span data-contrast="auto">TVG’s vaccine solutions</span><span data-ccp-props="{}"> </span></h5> <p><span data-contrast="auto">The Vaccine Group (TVG) hope to address these challenges. With “key opinion leaders” for the two diseases in the UK and Canada, TVG has inserted transgenes for protective antigens from each virus into two separate constructs through genetic manipulation. Both vaccine candidates have been shown to be genetically stable and have demonstrated “stable and prolonged” protein expression in tissue culture over multiple passages. The technology works by introducing a benign virus to cattle, which stimulates the expression of proteins to induce an immune response. </span><span data-ccp-props="{}"> </span></p> <p><span data-contrast="auto">Chief Executive Officer at TVG, Dr Jeremy Salt, reflected that infectious diseases are a “major cause for concern” for cattle farmers around the world, leading to “significant losses – both in terms of animal health and welfare, and in financial terms”. </span><span data-ccp-props="{}"> </span></p> <blockquote> <h6><span data-contrast="auto">“Our goal in developing a viral vector platform for use in cattle effective vaccines is to overcome some of the deficiencies that affect the current commercialised vaccines. By doing so, we can better protect the farmers, their animals, and their livelihoods.”</span><span data-ccp-props="{}"> </span></h6> </blockquote> <p><span data-contrast="auto">Dr Salt also hopes to “make beef and milk production more efficient, humane, and sustainable”, whilst “helping the sector address the global challenges of antibiotic resistance and carbon emissions”. </span><span data-ccp-props="{}"> </span></p> <p><span data-contrast="auto">We look forward to hearing from Dr Salt at the Congress in Barcelona in just a few weeks; <a href="https://secure.terrapinn.com/V5/step1.aspx?E=10840" target="_blank" rel="noopener">get your tickets to join us there</a> and don’t forget to <a href="https://vaccinenation.org/subscribe/" target="_blank" rel="noopener">subscribe to our weekly newsletters here</a>.</span><span data-ccp-props="{}"> </span></p> <div class="sharedaddy sd-sharing-enabled"><div class="robots-nocontent sd-block sd-social sd-social-icon sd-sharing"><h3 class="sd-title">Share this:</h3><div class="sd-content"><ul><li class="share-x"><a rel="nofollow noopener noreferrer" data-shared="sharing-x-8744" class="share-x sd-button share-icon no-text" href="https://vaccinenation.org/technology/the-vaccine-group-and-apha-secure-animal-vaccine-grant/?share=x" target="_blank" title="Click to share on X" ><span></span><span class="sharing-screen-reader-text">Click to share on X (Opens in new window)</span></a></li><li class="share-linkedin"><a rel="nofollow noopener noreferrer" data-shared="sharing-linkedin-8744" class="share-linkedin sd-button share-icon no-text" href="https://vaccinenation.org/technology/the-vaccine-group-and-apha-secure-animal-vaccine-grant/?share=linkedin" target="_blank" title="Click to share on LinkedIn" ><span></span><span class="sharing-screen-reader-text">Click to share on LinkedIn (Opens in new window)</span></a></li><li class="share-facebook"><a rel="nofollow noopener noreferrer" data-shared="sharing-facebook-8744" class="share-facebook sd-button share-icon no-text" href="https://vaccinenation.org/technology/the-vaccine-group-and-apha-secure-animal-vaccine-grant/?share=facebook" target="_blank" title="Click to share on Facebook" ><span></span><span class="sharing-screen-reader-text">Click to share on Facebook (Opens in new window)</span></a></li><li class="share-jetpack-whatsapp"><a rel="nofollow noopener noreferrer" data-shared="" class="share-jetpack-whatsapp sd-button share-icon no-text" href="https://vaccinenation.org/technology/the-vaccine-group-and-apha-secure-animal-vaccine-grant/?share=jetpack-whatsapp" target="_blank" title="Click to share on WhatsApp" ><span></span><span class="sharing-screen-reader-text">Click to share on WhatsApp (Opens in new window)</span></a></li><li class="share-print"><a rel="nofollow noopener noreferrer" data-shared="" class="share-print sd-button share-icon no-text" href="https://vaccinenation.org/technology/the-vaccine-group-and-apha-secure-animal-vaccine-grant/#print" target="_blank" title="Click to print" ><span></span><span class="sharing-screen-reader-text">Click to print (Opens in new window)</span></a></li><li class="share-email"><a rel="nofollow noopener noreferrer" data-shared="" class="share-email sd-button share-icon no-text" href="mailto:?subject=%5BShared%20Post%5D%20The%20Vaccine%20Group%20and%20APHA%20secure%20animal%20vaccine%20grant&body=https%3A%2F%2Fvaccinenation.org%2Ftechnology%2Fthe-vaccine-group-and-apha-secure-animal-vaccine-grant%2F&share=email" target="_blank" title="Click to email a link to a friend" data-email-share-error-title="Do you have email set up?" data-email-share-error-text="If you're having problems sharing via email, you might not have email set up for your browser. 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--smush-placeholder-aspect-ratio: 150/150;" /><noscript><img width="150" height="150" src="https://vaccinenation.org/wp-content/uploads/2024/05/Heading-2-150x150.png?crop=1" class="attachment-thumbnail size-thumbnail wp-post-image" alt="" data-pin-nopin="true" /></noscript><span class="yarpp-thumbnail-title">Partnering for pigs: Pirbright and TVG tackle ASF</span></a> <a class='yarpp-thumbnail' rel='norewrite' href='https://vaccinenation.org/global-health/msd-animal-health-pursues-cattle-health-success/' title='MSD Animal Health pursues cattle health success'> <img width="150" height="150" data-src="https://vaccinenation.org/wp-content/uploads/2023/11/Untitled-design-51-150x150.png?crop=1" class="attachment-thumbnail size-thumbnail wp-post-image lazyload" alt="" data-pin-nopin="true" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" style="--smush-placeholder-width: 150px; --smush-placeholder-aspect-ratio: 150/150;" /><noscript><img width="150" height="150" src="https://vaccinenation.org/wp-content/uploads/2023/11/Untitled-design-51-150x150.png?crop=1" class="attachment-thumbnail size-thumbnail wp-post-image" alt="" data-pin-nopin="true" /></noscript><span class="yarpp-thumbnail-title">MSD Animal Health pursues cattle health success</span></a> </div> </div> </div> <div class="et_post_meta_wrapper"> <section id="comment-wrap"> <div id="comment-section" class="nocomments"> </div> <div id="respond" class="comment-respond"> <h3 id="reply-title" class="comment-reply-title">Leave a Comment<small><a rel="nofollow" id="cancel-comment-reply-link" href="/technology/the-vaccine-group-and-apha-secure-animal-vaccine-grant/#respond" style="display:none;">Cancel reply</a></small></h3> <form id="commentform" class="comment-form"> <iframe title="Comment Form" data-src="https://jetpack.wordpress.com/jetpack-comment/?blogid=209026272&postid=8744&comment_registration=0&require_name_email=1&stc_enabled=0&stb_enabled=0&show_avatars=1&avatar_default=mystery&greeting=Leave+a+Comment&jetpack_comments_nonce=1f222559a3&greeting_reply=Leave+a+Reply+to+%25s&color_scheme=light&lang=en_US&jetpack_version=14.1-a.7&iframe_unique_id=1&show_cookie_consent=10&has_cookie_consent=0&is_current_user_subscribed=0&token_key=%3Bnormal%3B&sig=7d01c9763237f06f62b51159a3b83587fc85ea3c#parent=https%3A%2F%2Fvaccinenation.org%2Ftechnology%2Fthe-vaccine-group-and-apha-secure-animal-vaccine-grant%2F" name="jetpack_remote_comment" style="width:100%; 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