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sensitizer</title> <meta name="description" content="Search results for: sensitizer"> <meta name="keywords" content="sensitizer"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="sensitizer"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 15</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: sensitizer</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> Beneficiation of Dye Sensitized Solar Cell as Energy Saving from Apple Skin with TiO2 Electrolysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Astari%20Indarsari">Astari Indarsari</a>, <a href="https://publications.waset.org/abstracts/search?q=Bastian%20B.%20Purba"> Bastian B. Purba</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Fadlilah"> Muhammad Fadlilah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In Indonesian climates that have the tropic climate, one of the potential energy sources is coming from solar energy. From the solar energy, we can convert it into the others energy, such as electrical energy. In this topic, we want to do the research about Dye Sensitized Solar Cell (DSSC). The materials that we use as sensitizer is anthocyanin that we extract from apple skin, because the anthocyanin is one of the most effective as a sensitizer for DSSC. The variable in this research is pH. The pH that we used are pH 0,5; pH 1; pH 1,5; pH 2; pH 2,5. The method is electrolysis, and we use TiO2 as sensitized material. The hypothesis from this research is the smaller pH can make higher the efficiency of the absorbent of the solar energy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anthocyanin" title="anthocyanin">anthocyanin</a>, <a href="https://publications.waset.org/abstracts/search?q=TiO2" title=" TiO2"> TiO2</a>, <a href="https://publications.waset.org/abstracts/search?q=DSSC" title=" DSSC"> DSSC</a>, <a href="https://publications.waset.org/abstracts/search?q=apple%20skin" title=" apple skin"> apple skin</a> </p> <a href="https://publications.waset.org/abstracts/57912/beneficiation-of-dye-sensitized-solar-cell-as-energy-saving-from-apple-skin-with-tio2-electrolysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/57912.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">292</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> Swelling Behavior of Cross-Linked Poly (2-hydroxyethyl methacrylate)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Salah%20Hamri">Salah Hamri</a>, <a href="https://publications.waset.org/abstracts/search?q=Tewfik%20Bouchaour"> Tewfik Bouchaour</a>, <a href="https://publications.waset.org/abstracts/search?q=Ulrich%20Maschke"> Ulrich Maschke</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this works is the study of swelling ratio of cross-linked polymer networks poly (2-hydroxyethyl methacrylate) (PHEMA). The system composed of erythrosine and Triethanolamine, in aqueous medium, is used as photo-initiator and 1,6-Hexanediol diacrylate as cross-linker. The analysis of UV-visible and infrared spectra, which were taken at different times during polymerization/cross linking, makes it possible to obtain useful information on the reaction mechanism. The swelling behavior was study by changing the nature of solvent, dye sensitizer (erythrosine, rose Bengal and eosin), and pH of the medium. The exploitation of experimental results using Fick diffusion model is also expected and shows a good correlation between theoretical and experimental results. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cross-linker" title="cross-linker">cross-linker</a>, <a href="https://publications.waset.org/abstracts/search?q=photo-sensitizer" title=" photo-sensitizer"> photo-sensitizer</a>, <a href="https://publications.waset.org/abstracts/search?q=polymer%20network" title=" polymer network"> polymer network</a>, <a href="https://publications.waset.org/abstracts/search?q=swelling%20ratio" title=" swelling ratio"> swelling ratio</a> </p> <a href="https://publications.waset.org/abstracts/29880/swelling-behavior-of-cross-linked-poly-2-hydroxyethyl-methacrylate" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29880.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">316</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> Effect of Solvents in the Extraction and Stability of Anthocyanin from the Petals of Caesalpinia pulcherrima for Natural Dye-Sensitized Solar Cell</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=N.%20Prabavathy">N. Prabavathy</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Balasundaraprabhu"> R. Balasundaraprabhu</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Shalini"> S. Shalini</a>, <a href="https://publications.waset.org/abstracts/search?q=Dhayalan%20Velauthapillai"> Dhayalan Velauthapillai</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Prasanna"> S. Prasanna</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Muthukumarasamy"> N. Muthukumarasamy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Dye sensitized solar cell (DSSC) has become a significant research area due to their fundamental and scientific importance in the area of energy conversion. Synthetic dyes as sensitizer in DSSC are efficient and durable but they are costlier, toxic and have the tendency to degrade. Natural sensitizers contain plant pigments such as anthocyanin, carotenoid, flavonoid, and chlorophyll which promote light absorption as well as injection of charges to the conduction band of TiO2 through the sensitizer. But, the efficiency of natural dyes is not up to the mark mainly due to instability of the pigment such as anthocyanin. The stability issues in vitro are mainly due to the effect of solvents on extraction of anthocyanins and their respective pH. Taking this factor into consideration, in the present work, the anthocyanins were extracted from the flower Caesalpinia pulcherrima (C. pulcherrimma) with various solvents and their respective stability and pH values are discussed. The usage of citric acid as solvent to extract anthocyanin has shown good stability than other solvents. It also helps in enhancing the sensitization properties of anthocyanins with Titanium dioxide (TiO2) nanorods. The IPCE spectra show higher photovoltaic performance for dye sensitized TiO2nanorods using citric acid as solvent. The natural DSSC using citric acid as solvent shows a higher efficiency compared to other solvents. Hence citric acid performs to be a safe solvent for natural DSSC in boosting the photovoltaic performance and maintaining the stability of anthocyanins. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Caesalpinia%20pulcherrima" title="Caesalpinia pulcherrima">Caesalpinia pulcherrima</a>, <a href="https://publications.waset.org/abstracts/search?q=citric%20acid" title=" citric acid"> citric acid</a>, <a href="https://publications.waset.org/abstracts/search?q=dye%20sensitized%20solar%20cells" title=" dye sensitized solar cells"> dye sensitized solar cells</a>, <a href="https://publications.waset.org/abstracts/search?q=TiO%E2%82%82%20nanorods" title=" TiO₂ nanorods"> TiO₂ nanorods</a> </p> <a href="https://publications.waset.org/abstracts/71483/effect-of-solvents-in-the-extraction-and-stability-of-anthocyanin-from-the-petals-of-caesalpinia-pulcherrima-for-natural-dye-sensitized-solar-cell" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/71483.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">290</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> Synthesis and Evaluation of Photovoltaic Properties of an Organic Dye for Dye-Sensitized Solar Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Hosseinnejad">M. Hosseinnejad</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Gharanjig"> K. Gharanjig</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the present study, metal free organic dyes were prepared and used as photo-sensitizers in dye-sensitized solar cells. Double rhodanine was utilized as the fundamental electron acceptor group to which electron donor aldehyde with varying substituents was attached to produce new organic dye. This dye was first purified and then characterized by analytical techniques. Spectrophotometric evaluations of the prepared dye in solution and on a nano anatase TiO<sub>2</sub> substrate were carried out in order to assess possible changes in the status of the dyes in different environments. The results show that the dye form j-type aggregates on the nano TiO<sub>2</sub>. Additionally, oxidation potential measurements were also carried out. Finally, dye sensitized solar cell based on synthesized dye was fabricated in order to determine the photovoltaic behavior and conversion efficiency of individual dye. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=conversion%20efficiency" title="conversion efficiency">conversion efficiency</a>, <a href="https://publications.waset.org/abstracts/search?q=dye-sensitized%20solar%20cell" title=" dye-sensitized solar cell"> dye-sensitized solar cell</a>, <a href="https://publications.waset.org/abstracts/search?q=photovoltaic%20behavior" title=" photovoltaic behavior"> photovoltaic behavior</a>, <a href="https://publications.waset.org/abstracts/search?q=sensitizer" title=" sensitizer"> sensitizer</a> </p> <a href="https://publications.waset.org/abstracts/42717/synthesis-and-evaluation-of-photovoltaic-properties-of-an-organic-dye-for-dye-sensitized-solar-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/42717.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">183</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> A Luminescence Study of Bi³⁺ Codoping on Eu³⁺ Doped YPO₄</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=N.%20Yaiphaba">N. Yaiphaba</a>, <a href="https://publications.waset.org/abstracts/search?q=Elizabeth%20C.%20H."> Elizabeth C. H.</a> </p> <p class="card-text"><strong>Abstract:</strong></p> YPO₄ nanoparticles codoped with Eu³⁺(5 at.%) and Bi³⁺(0, 1, 3, 5, 7, 10, 12, 15, 20 at.%) have been prepared in poly acrylic acid (PAA)-H₂O medium by hydrothermal synthesis by maintaining a temperature of 180oC. The crystalline structure of as-prepared and 500oC annealed samples transforms from tetragonal (JCPDS-11-0254) to hexagonal phase (JCPDS-42-0082) with increasing concentration of Bi³⁺ ions. However, 900oC annealed samples exhibit tetragonal structure. The crystallite size of the particles varies from 19-50 nm. The luminescence intensity increases at lower concentration of Bi³⁺ ions and then decreases with increasing Bi3+ ion concentrations. The luminescence intensity further increases on annealing at 500oC and 900oC. Further, 900oC annealed samples show sharp increase in luminescence intensity. Moreover, the samples follow bi-exponential decay indicating energy transfer from donor to the activator or non-uniform distribution of ions in the samples. The samples on excitation at 318 nm exhibit near white emission while at 394 nm excitation show emission in the red region. The as-prepared samples are redispersible and have potential applications in display devices, metal ion sensing, biological labelling, etc. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=charge%20transfer" title="charge transfer">charge transfer</a>, <a href="https://publications.waset.org/abstracts/search?q=sensitizer" title=" sensitizer"> sensitizer</a>, <a href="https://publications.waset.org/abstracts/search?q=activator" title=" activator"> activator</a>, <a href="https://publications.waset.org/abstracts/search?q=annealing" title=" annealing"> annealing</a> </p> <a href="https://publications.waset.org/abstracts/159353/a-luminescence-study-of-bi3-codoping-on-eu3-doped-ypo4" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/159353.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">66</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Multifunctional Bismuth-Based Nanoparticles as Theranostic Agent for Imaging and Radiation Therapy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Azimeh%20Rajaee">Azimeh Rajaee</a>, <a href="https://publications.waset.org/abstracts/search?q=Lingyun%20Zhao"> Lingyun Zhao</a>, <a href="https://publications.waset.org/abstracts/search?q=Shi%20Wang"> Shi Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Yaqiang%20Liu"> Yaqiang Liu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In recent years many studies have been focused on bismuth-based nanoparticles as radiosensitizer and contrast agent in radiation therapy and imaging due to the high atomic number (Z = 82), high photoelectric absorption, low cost, and low toxicity. This study aims to introduce a new multifunctional bismuth-based nanoparticle as a theranostic agent for radiotherapy, computed tomography (CT) and magnetic resonance imaging (MRI). We synthesized bismuth ferrite (BFO, BiFeO3) nanoparticles by sol-gel method and surface of the nanoparticles were modified by Polyethylene glycol (PEG). After proved biocompatibility of the nanoparticles, the ability of them as contract agent in Computed tomography (CT) and magnetic resonance imaging (MRI) was investigated. The relaxation time rate (R2) in MRI and Hounsfield unit (HU) in CT imaging were increased with the concentration of the nanoparticles. Moreover, the effect of nanoparticles on dose enhancement in low energy was investigated by clonogenic assay. According to clonogenic assay, sensitizer enhancement ratios (SERs) were obtained as 1.35 and 1.76 for nanoparticle concentrations of 0.05 mg/ml and 0.1 mg/ml, respectively. In conclusion, our experimental results demonstrate that the multifunctional nanoparticles have the ability to employ as multimodal imaging and therapy to enhance theranostic efficacy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=molecular%20imaging" title="molecular imaging">molecular imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=nanomedicine" title=" nanomedicine"> nanomedicine</a>, <a href="https://publications.waset.org/abstracts/search?q=radiotherapy" title=" radiotherapy"> radiotherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=theranostics" title=" theranostics"> theranostics</a> </p> <a href="https://publications.waset.org/abstracts/95005/multifunctional-bismuth-based-nanoparticles-as-theranostic-agent-for-imaging-and-radiation-therapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/95005.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">317</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Sensing Characteristics of Gold Nanoparticles Decorated Sputtered Tin Oxide Thin Films as Nitrogen Oxide Sensor</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Qasem%20Drmosh">Qasem Drmosh</a>, <a href="https://publications.waset.org/abstracts/search?q=Zain%20Yamai"> Zain Yamai</a>, <a href="https://publications.waset.org/abstracts/search?q=Amar%20Mohamedkhair"> Amar Mohamedkhair</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdulmajid%20Hendi"> Abdulmajid Hendi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In recent years, there has been a growing interest in the reduction of the nitrogen oxides NOx (NO2, NO) gases resulting from automotive or combustion emissions. Recently, metal additives in nanometer dimension onto the surface of SnO2 nanorods, nanowires and nanotubes sensitizer to further increase the sensor response have been used. In contrast, there is a lack study focused on modifying the surface of SnO2 thin films by nanoparticles. The challenge in case of thin films is how to fabricate these nanoparticles on the surfaces in cost-effective method, high purity as well as without hampering electrical and topographical properties. Here in this report, a simple and facile strategy has been demonstrated to acquire high sensitive and fast response NO2 gas sensor. Structural, electrical, morphological, optical, and compositional properties of the fabricated sensors were investigated through different analytical technique including X-ray diffraction (XRD), Field emission scanning emission microscope (FESEM) and X-ray photoelectron spectroscopy (XPS). The sensing performance of the prepared sensors are studied at different temperatures for various concentrations of NO2 and compared with pristine SnO2 film. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=NO2%20sensor" title="NO2 sensor">NO2 sensor</a>, <a href="https://publications.waset.org/abstracts/search?q=SnO2" title=" SnO2"> SnO2</a>, <a href="https://publications.waset.org/abstracts/search?q=sputtering" title=" sputtering"> sputtering</a>, <a href="https://publications.waset.org/abstracts/search?q=thin%20films" title=" thin films"> thin films</a> </p> <a href="https://publications.waset.org/abstracts/56189/sensing-characteristics-of-gold-nanoparticles-decorated-sputtered-tin-oxide-thin-films-as-nitrogen-oxide-sensor" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/56189.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">211</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Iranian Refinery Vacuum Residue Upgrading Using Microwave Irradiation: Effects of Catalyst Type and Amount</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zarrin%20Nasri">Zarrin Nasri</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Microwave irradiation is an innovative technology in the petroleum industry. This kind of energy has been considered to convert vacuum residue of oil refineries into useful products. The advantages of microwaves energy are short time, fast heating, high energy efficiency, and precise process control. In this paper, the effects of catalyst type and amount have been investigated on upgrading of vacuum residue using microwave irradiation. The vacuum residue used in this research is from Tehran oil refinery, Iran. Additives include different catalysts, active carbon as sensitizer, and sodium borohydride as a solid hydrogen donor. Various catalysts contain iron, nickel, molybdenum disulfide, iron oxide and copper. The amount of catalysts in two cases of presence and absence of sodium borohydride have been evaluated. The objective parameters include temperature, asphaltene, viscosity, and API. The specifications of vacuum residue are API, 8.79, viscosity, 16391 cSt (60°C), asphaltene, 13.3 wt %. The results show that there is a significant difference between the effects of catalysts. Among the used catalysts, Fe powder is the best catalyst for upgrading vacuum residue using microwave irradiation and resulted in asphaltene reduction, 31.3 %; viscosity reduction, 76.43 %; and 23.43 % in API increase. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=asphaltene" title="asphaltene">asphaltene</a>, <a href="https://publications.waset.org/abstracts/search?q=microwave" title=" microwave"> microwave</a>, <a href="https://publications.waset.org/abstracts/search?q=upgrading" title=" upgrading"> upgrading</a>, <a href="https://publications.waset.org/abstracts/search?q=vacuum%20residue" title=" vacuum residue"> vacuum residue</a>, <a href="https://publications.waset.org/abstracts/search?q=viscosity" title=" viscosity"> viscosity</a> </p> <a href="https://publications.waset.org/abstracts/81731/iranian-refinery-vacuum-residue-upgrading-using-microwave-irradiation-effects-of-catalyst-type-and-amount" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81731.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">255</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Cu Nanoparticle Embedded-Zno Nanoplate Thin Films for Highly Efficient Photocatalytic Hydrogen Production </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Premrudee%20Promdet">Premrudee Promdet</a>, <a href="https://publications.waset.org/abstracts/search?q=Fan%20Cui"> Fan Cui</a>, <a href="https://publications.waset.org/abstracts/search?q=Gi%20Byoung%20%20Hwang"> Gi Byoung Hwang</a>, <a href="https://publications.waset.org/abstracts/search?q=Ka%20Chuen%20To"> Ka Chuen To</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjayan%20Sathasivam"> Sanjayan Sathasivam</a>, <a href="https://publications.waset.org/abstracts/search?q=Claire%20J.%20%20Carmalt"> Claire J. Carmalt</a>, <a href="https://publications.waset.org/abstracts/search?q=Ivan%20P.%20Parkin"> Ivan P. Parkin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A novel single-step fabrication of Cu nanoparticle embedded ZnO (Cu.ZnO) thin films was developed by aerosol-assisted chemical vapor deposition for stable and efficient hydrogen production in Photoelectrochemical (PEC) cell. In this approach, the Cu.ZnO nanoplate thin films were grown by using acetic acid to promote preferential growth and enhance surface active sites, where Cu nanoparticles can be formed under chemical deposition by reduction of Cu salt. Studies using photoluminescence spectroscopy indicate the enhanced photocatalytic performance is attributed to hot electron generated from SPR. The Cu metal in the composite material is functioning as a sensitizer to supply electrons to the semiconductor resulting in enhanced electron density for redox reaction. This work not only describes a way to obtain photoanodes with high photocatalytic activity but also suggests a low-cost route towards production of photocatalysts for hydrogen production. This work also supports a vital need to understand electron transfer between photoexcited semiconductor materials and metals, a requirement for tailoring the properties of semiconductor/metal composites. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=photocatalysis" title="photocatalysis">photocatalysis</a>, <a href="https://publications.waset.org/abstracts/search?q=photoelectrochemical%20cell%20%28PEC%29" title=" photoelectrochemical cell (PEC)"> photoelectrochemical cell (PEC)</a>, <a href="https://publications.waset.org/abstracts/search?q=aerosol-assisted%20chemical%20vapor%20deposition%20%28AACVD%29" title=" aerosol-assisted chemical vapor deposition (AACVD)"> aerosol-assisted chemical vapor deposition (AACVD)</a>, <a href="https://publications.waset.org/abstracts/search?q=surface%20plasmon%20resonance%20%28SPR%29" title=" surface plasmon resonance (SPR)"> surface plasmon resonance (SPR)</a> </p> <a href="https://publications.waset.org/abstracts/138288/cu-nanoparticle-embedded-zno-nanoplate-thin-films-for-highly-efficient-photocatalytic-hydrogen-production" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/138288.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">219</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Statistical Mechanical Approach in Modeling of Hybrid Solar Cells for Photovoltaic Applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20E.%20Kobryn">A. E. Kobryn</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We present both descriptive and predictive modeling of structural properties of blends of PCBM or organic-inorganic hybrid perovskites of the type CH3NH3PbX3 (X=Cl, Br, I) with P3HT, P3BT or squaraine SQ2 dye sensitizer, including adsorption on TiO2 clusters having rutile (110) surface. In our study, we use a methodology that allows computing the microscopic structure of blends on the nanometer scale and getting insight on miscibility of its components at various thermodynamic conditions. The methodology is based on the integral equation theory of molecular liquids in the reference interaction site representation/model (RISM) and uses the universal force field. Input parameters for RISM, such as optimized molecular geometries and charge distribution of interaction sites, are derived with the use of the density functional theory methods. To compare the diffusivity of the PCBM in binary blends with P3HT and P3BT, respectively, the study is complemented with MD simulation. A very good agreement with experiment and the reports of alternative modeling or simulation is observed for PCBM in P3HT system. The performance of P3BT with perovskites, however, seems as expected. The calculated nanoscale morphologies of blends of P3HT, P3BT or SQ2 with perovskites, including adsorption on TiO2, are all new and serve as an instrument in rational design of organic/hybrid photovoltaics. They are used in collaboration with experts who actually make prototypes or devices for practical applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=multiscale%20theory%20and%20modeling" title="multiscale theory and modeling">multiscale theory and modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoscale%20morphology" title=" nanoscale morphology"> nanoscale morphology</a>, <a href="https://publications.waset.org/abstracts/search?q=organic-inorganic%20halide%20perovskites" title=" organic-inorganic halide perovskites"> organic-inorganic halide perovskites</a>, <a href="https://publications.waset.org/abstracts/search?q=three%20dimensional%20distribution" title=" three dimensional distribution"> three dimensional distribution</a> </p> <a href="https://publications.waset.org/abstracts/81016/statistical-mechanical-approach-in-modeling-of-hybrid-solar-cells-for-photovoltaic-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81016.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">155</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Disruption of Cancer Cell Proliferation by Magnetic Field</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ming%20Ze%20Kao">Ming Ze Kao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Static magnetic fields (SMF) are widely used in several medical applications, especially in diagnosis of tumors. However, biological effects of the SMFs on modulating cell physiology through the Lorentz force, which is highly frequency and magnitude dependent, remain to be elucidated. Specific patterns from SMFs of static MF, delivered by means of Halbach array magnets with a gradient increment of 6.857mT/mm from center to border, were found to have profound inhibitory effect on the growth rate of human cell line derived from Nasopharyngeal carcinoma patients. The SMFs, which were shown to be noncontact, selectively impact rapid dividing cells while quiescent cells stay intact. The phenomenon acts in two modes: the arrest of cell proliferation in the G2/M phase and destruction of cell mitosis in cell division. First mode is manifested by impacting the proper formation of mitotic spindle, whereas the second results in disintegration of the cancer cell. Both modes are demonstrated when SMF was applied for 24 hours to cancer cells, the results revealed that metaphase arrest during mitosis due to activation of DNA damage response (DDR), resulting in high expression of ATM-NBS1-CHEK signaling pathways and higher G2/M phase ratio compared with control group. Here, experimental data suggest that the SMFs cause activation of cell cycle checkpoints, which implies the MFs as a potential therapeutic modality as a sensitizer for radiotherapy or chemotherapy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=static%20magnetic%20field" title="static magnetic field">static magnetic field</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA%20damage%20response" title=" DNA damage response"> DNA damage response</a>, <a href="https://publications.waset.org/abstracts/search?q=Halbach%20array" title=" Halbach array"> Halbach array</a>, <a href="https://publications.waset.org/abstracts/search?q=magnetic%20therapy" title=" magnetic therapy"> magnetic therapy</a> </p> <a href="https://publications.waset.org/abstracts/98067/disruption-of-cancer-cell-proliferation-by-magnetic-field" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/98067.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">114</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Degradation Study of Food Colorants by SingletOxygen</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20T.%20Toci">A. T. Toci</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20V.%20B.%20Zanoni"> M. V. B. Zanoni</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The advanced oxidation processes have been defined as destructive technologies treatment of wastewater. These involve the formation of powerful oxidizing agents (usually hydroxyl radical .OH) capable of reacting with organic compounds present in wastewater, transforming damaging substances in CO2 and H2O (mineralization) or other innocuous products. However, the photochemical degradation with singlet oxygen has been little explored as oxidative pathway for the treatment of effluents containing food colorants. The molecular oxygen is an effective suppressor of organic molecules in the triplet excited state. One of the possible results of the physical withdrawal is the formation of singlet oxygen. Studies with singlet oxygen (1O2) show an high reactivity of the excited state of the molecule with olefins, aromatic hydrocarbons and a number of other organic and inorganic compounds. Its reactivity is about 2500 times larger than the oxygen in the ground state. Thus, in this work, it was studied the degradation of some dyes used in food industry (tartrazine, sunset yellow, erythrosine and carmoisine) by singlet oxygen. The sensitizer used for generating the 1O2 was methylene blue, which has a quantum yield generation of 0.50. Samples were prepared in water at a concentration of 5 ppm and irradiated with a sunlight simulator (Newport brand, model no. 67005) by consecutive 8h. The absorption spectra of UV-Vis molecules were made each hour irradiation. The degradation kinetics for each dye was determined using the maximum length of each dye absorption. The analysis by UV-Vis revealed that the processes were very efficient for the colorants sunset yellow and carmoisine. Both presented degradation kinetics of order zero with degradation constants 0.416 and 0.104, respectively. In the case of sunset yellow degradation reached 53% after 7h irradiation, Demonstrating the process efficiency. The erithrosine presented during the period irradiated a oscillating degradation kinetics, which requires further study. In the other hand, tartrazine was stable in the presence of 1O2. The investigation of the dyes degradation products owned degradation by 1O2 are underway, the techniques used for this are MS and NMR. The results of this study will enable the application of the cleanest methods for the treatment of industrial effluents, as there are other non-toxic and polluting molecules to generate 1O2. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=food%20colourants" title="food colourants">food colourants</a>, <a href="https://publications.waset.org/abstracts/search?q=singlet%20oxygen" title=" singlet oxygen"> singlet oxygen</a>, <a href="https://publications.waset.org/abstracts/search?q=degradation" title=" degradation"> degradation</a>, <a href="https://publications.waset.org/abstracts/search?q=wastewater" title=" wastewater"> wastewater</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidative" title=" oxidative"> oxidative</a> </p> <a href="https://publications.waset.org/abstracts/25189/degradation-study-of-food-colorants-by-singletoxygen" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/25189.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">397</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Development of High-Efficiency Down-Conversion Fluoride Phosphors to Increase the Efficiency of Solar Panels</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20V.%20Kuznetsov">S. V. Kuznetsov</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20N.%20Mayakova"> M. N. Mayakova</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20Yu.%20Proydakova"> V. Yu. Proydakova</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20V.%20Pavlov"> V. V. Pavlov</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20S.%20Nizamutdinov"> A. S. Nizamutdinov</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20A.%20Morozov"> O. A. Morozov</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20V.%20Voronov"> V. V. Voronov</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20P.%20Fedorov"> P. P. Fedorov </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Increase in the share of electricity received by conversion of solar energy results in the reduction of the industrial impact on the environment from the use of the hydrocarbon energy sources. One way to increase said share is to improve the efficiency of solar energy conversion in silicon-based solar panels. Such efficiency increase can be achieved by transferring energy from sunlight-insensitive areas of work of silicon solar panels to the area of their photoresistivity. To achieve this goal, a transition to new luminescent materials with the high quantum yield of luminescence is necessary. Improvement in the quantum yield can be achieved by quantum cutting, which allows obtaining a quantum yield of down conversion of more than 150% due to the splitting of high-energy photons of the UV spectral range into lower-energy photons of the visible and near infrared spectral ranges. The goal of present work is to test approach of excitation through sensibilization of 4f-4f fluorescence of Yb3+ by various RE ions absorbing in UV and Vis spectral ranges. One of promising materials for quantum cutting luminophores are fluorides. In our investigation we have developed synthesis of nano- and submicron powders of calcium fluoride and strontium doped with rare-earth elements (Yb: Ce, Yb: Pr, Yb: Eu) of controlled dimensions and shape by co-precipitation from water solution technique. We have used Ca(NO3)2*4H2O, Sr(NO3)2, HF, NH4F as precursors. After initial solutions of nitrates were prepared they have been mixed with fluorine containing solution by dropwise manner. According to XRD data, the synthesis resulted in single phase samples with fluorite structure. By means of SEM measurements, we have confirmed spherical morphology and have determined sizes of particles (50-100 nm after synthesis and 150-300 nm after calcination). Temperature of calcination appeared to be 600°C. We have investigated the spectral-kinetic characteristics of above mentioned compounds. Here the diffuse reflection and laser induced fluorescence spectra of Yb3+ ions excited at around 4f-4f and 4f-5d transitions of Pr3+, Eu3+ and Ce3+ ions in the synthesized powders are reported. The investigation of down conversion luminescence capability of synthesized compounds included measurements of fluorescence decays and quantum yield of 2F5/2-2F7/2 fluorescence of Yb3+ ions as function of Yb3+ and sensitizer contents. An optimal chemical composition of CaF2-YbF3- LnF3 (Ln=Ce, Eu, Pr), SrF2-YbF3-LnF3 (Ln=Ce, Eu, Pr) micro- and nano- powders according to criteria of maximal IR fluorescence yield is proposed. We suppose that investigated materials are prospective in solar panels improvement applications. Work was supported by Russian Science Foundation grant #17-73- 20352. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=solar%20cell" title="solar cell">solar cell</a>, <a href="https://publications.waset.org/abstracts/search?q=fluorides" title=" fluorides"> fluorides</a>, <a href="https://publications.waset.org/abstracts/search?q=down-conversion%20luminescence" title=" down-conversion luminescence"> down-conversion luminescence</a>, <a href="https://publications.waset.org/abstracts/search?q=maximum%20quantum%20yield" title=" maximum quantum yield"> maximum quantum yield</a> </p> <a href="https://publications.waset.org/abstracts/79876/development-of-high-efficiency-down-conversion-fluoride-phosphors-to-increase-the-efficiency-of-solar-panels" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/79876.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">272</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Enhancement of Radiosensitization by Aptamer 5TR1-Functionalized AgNCs for Triple-Negative Breast Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Xuechun%20Kan">Xuechun Kan</a>, <a href="https://publications.waset.org/abstracts/search?q=Dongdong%20Li"> Dongdong Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Fan%20Li"> Fan Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Peidang%20Liu"> Peidang Liu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer with a poor prognosis, and radiotherapy is one of the main treatment methods. However, due to the obvious resistance of tumor cells to radiotherapy, high dose of ionizing radiation is required during radiotherapy, which causes serious damage to normal tissues near the tumor. Therefore, how to improve radiotherapy resistance and enhance the specific killing of tumor cells by radiation is a hot issue that needs to be solved in clinic. Recent studies have shown that silver-based nanoparticles have strong radiosensitization, and silver nanoclusters (AgNCs) also provide a broad prospect for tumor targeted radiosensitization therapy due to their ultra-small size, low toxicity or non-toxicity, self-fluorescence and strong photostability. Aptamer 5TR1 is a 25-base oligonucleotide aptamer that can specifically bind to mucin-1 highly expressed on the membrane surface of TNBC 4T1 cells, and can be used as a highly efficient tumor targeting molecule. In this study, AgNCs were synthesized by DNA template based on 5TR1 aptamer (NC-T5-5TR1), and its role as a targeted radiosensitizer in TNBC radiotherapy was investigated. The optimal DNA template was first screened by fluorescence emission spectroscopy, and NC-T5-5TR1 was prepared. NC-T5-5TR1 was characterized by transmission electron microscopy, ultraviolet-visible spectroscopy and dynamic light scattering. The inhibitory effect of NC-T5-5TR1 on cell activity was evaluated using the MTT method. Laser confocal microscopy was employed to observe NC-T5-5TR1 targeting 4T1 cells and verify its self-fluorescence characteristics. The uptake of NC-T5-5TR1 by 4T1 cells was observed by dark-field imaging, and the uptake peak was evaluated by inductively coupled plasma mass spectrometry. The radiation sensitization effect of NC-T5-5TR1 was evaluated through cell cloning and in vivo anti-tumor experiments. Annexin V-FITC/PI double staining flow cytometry was utilized to detect the impact of nanomaterials combined with radiotherapy on apoptosis. The results demonstrated that the particle size of NC-T5-5TR1 is about 2 nm, and the UV-visible absorption spectrum detection verifies the successful construction of NC-T5-5TR1, and it shows good dispersion. NC-T5-5TR1 significantly inhibited the activity of 4T1 cells and effectively targeted and fluoresced within 4T1 cells. The uptake of NC-T5-5TR1 reached its peak at 3 h in the tumor area. Compared with AgNCs without aptamer modification, NC-T5-5TR1 exhibited superior radiation sensitization, and combined radiotherapy significantly inhibited the activity of 4T1 cells and tumor growth in 4T1-bearing mice. The apoptosis level of NC-T5-5TR1 combined with radiation was significantly increased. These findings provide important theoretical and experimental support for NC-T5-5TR1 as a radiation sensitizer for TNBC. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=5TR1%20aptamer" title="5TR1 aptamer">5TR1 aptamer</a>, <a href="https://publications.waset.org/abstracts/search?q=silver%20nanoclusters" title=" silver nanoclusters"> silver nanoclusters</a>, <a href="https://publications.waset.org/abstracts/search?q=radio%20sensitization" title=" radio sensitization"> radio sensitization</a>, <a href="https://publications.waset.org/abstracts/search?q=triple-negative%20breast%20cancer" title=" triple-negative breast cancer"> triple-negative breast cancer</a> </p> <a href="https://publications.waset.org/abstracts/184403/enhancement-of-radiosensitization-by-aptamer-5tr1-functionalized-agncs-for-triple-negative-breast-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/184403.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">60</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Exploiting the Tumour Microenvironment in Order to Optimise Sonodynamic Therapy for Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Maryam%20Mohammad%20Hadi">Maryam Mohammad Hadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Heather%20Nesbitt"> Heather Nesbitt</a>, <a href="https://publications.waset.org/abstracts/search?q=Hamzah%20Masood"> Hamzah Masood</a>, <a href="https://publications.waset.org/abstracts/search?q=Hashim%20Ahmed"> Hashim Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=Mark%20Emberton"> Mark Emberton</a>, <a href="https://publications.waset.org/abstracts/search?q=John%20Callan"> John Callan</a>, <a href="https://publications.waset.org/abstracts/search?q=Alexander%20MacRobert"> Alexander MacRobert</a>, <a href="https://publications.waset.org/abstracts/search?q=Anthony%20McHale"> Anthony McHale</a>, <a href="https://publications.waset.org/abstracts/search?q=Nikolitsa%20Nomikou"> Nikolitsa Nomikou</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sonodynamic therapy (SDT) utilises ultrasound in combination with sensitizers, such as porphyrins, for the production of cytotoxic reactive oxygen species (ROS) and the confined ablation of tumours. Ultrasound can be applied locally, and the acoustic waves, at frequencies between 0.5-2 MHz, are transmitted efficiently through tissue. SDT does not require highly toxic agents, and the cytotoxic effect only occurs upon ultrasound exposure at the site of the lesion. Therefore, this approach is not associated with adverse side effects. Further highlighting the benefits of SDT, no cancer cell population has shown resistance to therapy-triggered ROS production or their cytotoxic effects. This is particularly important, given the as yet unresolved issues of radiation and chemo-resistance, to the authors’ best knowledge. Another potential future benefit of this approach – considering its non-thermal mechanism of action – is its possible role as an adjuvant to immunotherapy. Substantial pre-clinical studies have demonstrated the efficacy and targeting capability of this therapeutic approach. However, SDT has yet to be fully characterised and appropriately exploited for the treatment of cancer. In this study, a formulation based on multistimulus-responsive sensitizer-containing nanoparticles that can accumulate in advanced prostate tumours and increase the therapeutic efficacy of SDT has been developed. The formulation is based on a polyglutamate-tyrosine (PGATyr) co-polymer carrying hematoporphyrin. The efficacy of SDT in this study was demonstrated using prostate cancer as the translational exemplar. The formulation was designed to respond to the microenvironment of advanced prostate tumours, such as the overexpression of the proteolytic enzymes, cathepsin-B and prostate-specific membrane antigen (PSMA), that can degrade the nanoparticles, reduce their size, improving both diffusions throughout the tumour mass and cellular uptake. The therapeutic modality was initially tested in vitro using LNCaP and PC3 cells as target cell lines. The SDT efficacy was also examined in vivo, using male SCID mice bearing LNCaP subcutaneous tumours. We have demonstrated that the PGATyr co-polymer is digested by cathepsin B and that digestion of the formulation by cathepsin-B, at tumour-mimicking conditions (acidic pH), leads to decreased nanoparticle size and subsequent increased cellular uptake. Sonodynamic treatment, at both normoxic and hypoxic conditions, demonstrated ultrasound-induced cytotoxic effects only for the nanoparticle-treated prostate cancer cells, while the toxicity of the formulation in the absence of ultrasound was minimal. Our in vivo studies in immunodeficient mice, using the hematoporphyrin-containing PGATyr nanoparticles for SDT, showed a 50% decrease in LNCaP tumour volumes within 24h, following IV administration of a single dose. No adverse effects were recorded, and body weight was stable. The results described in this study clearly demonstrate the promise of SDT to revolutionize cancer treatment. It emphasizes the potential of this therapeutic modality as a fist line treatment or in combination treatment for the elimination or downstaging of difficult to treat cancers, such as prostate, pancreatic, and advanced colorectal cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=sonodynamic%20therapy" title="sonodynamic therapy">sonodynamic therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title=" nanoparticles"> nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=tumour%20ablation" title=" tumour ablation"> tumour ablation</a>, <a href="https://publications.waset.org/abstracts/search?q=ultrasound" title=" ultrasound"> ultrasound</a> </p> <a href="https://publications.waset.org/abstracts/114703/exploiting-the-tumour-microenvironment-in-order-to-optimise-sonodynamic-therapy-for-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/114703.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">138</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); 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