Cardiac Biomechanics Research Lab - Homepage

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stroke="#CACED2" stroke-miterlimit="10"/> <path d="M1441 74.8783C1323.58 74.8783 1257.6 69.6813 1172.61 61.0586C1104.74 54.1747 943.973 25.069 875.684 22.8695C685.557 16.7317 673.121 76.085 424.847 74.8783C213.911 68.1778 184.5 36.5007 116 15.5004C47.5 -5.5 1 3.12031 1 3.12031" stroke="#CACED2" stroke-miterlimit="10"/> </svg> </div> </div> <div class="content-carousel-card-content"> <div class="heading"> <div class="field field--name-field-heading field--type-string field--label-hidden field__item">Cardiac Biomechanics Research Lab</div> </div> </div> </div> </a> </div> </div> </div> </div> <div class="field__item"> <div > <div class="columns text-vert-align--top remove-top-padding columns--layout-sidebar-left paragraph paragraph--type--kan-columns paragraph--view-mode--default no-decor"> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <h3>Lab Co-Directors</h3> <article class="media media--type-image media--view-mode-rounded-overlay" aria-label="Image about Dr. Tseng"> <div class="corner-detail mobile"> <svg version="1.1" id="Layer_1" x="0px" y="0px" width="50px" height="50px" viewBox="0 0 50 50" style="enable-background:new 0 0 50 50;" xml:space="preserve" xmlns:xlink="http://www.w3.org/1999/xlink"> <style type="text/css"> .st0{fill:none;stroke:#FEB80A;stroke-width:5;stroke-miterlimit:10;} </style> <polyline class="st0" points="2.5,50 2.5,2.5 50,2.5 " /> </svg> </div> <div class="corner-detail desktop"> <svg version="1.1" id="Layer_1" x="0px" y="0px" width="100px" height="100px" viewBox="0 0 100 100" style="enable-background:new 0 0 100 100;" xml:space="preserve" xmlns:xlink="http://www.w3.org/1999/xlink"> <style type="text/css"> .st0{fill:none;stroke:#FEB80A;stroke-width:5;stroke-miterlimit:10;} </style> <polyline class="st0" points="2.5,100 2.5,2.5 100,2.5 " /> </svg> </div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/rounded_overlay/public/2023-10/Tseng-Elaine-354x210.jpg.webp?itok=Dm2IaVW9" width="354" height="210" alt="Dr. Tseng" class="image-style-rounded-overlay"> </div> </article> <h3 style="margin-bottom:5px;"><a href="/node/17816" data-entity-type="node" data-entity-uuid="74426c14-3bc9-4b9d-abfd-cd3687411735" data-entity-substitution="canonical">Elaine Tseng, MD</a></h3><p style="font-size:1rem;margin-top:0px;">Professor of Surgery<br>Division of Adult Cardiothoracic Surgery</p> <article class="media media--type-image media--view-mode-rounded-overlay" aria-label="Image about Liang Ge 354x210"> <div class="corner-detail mobile"> <svg version="1.1" id="Layer_1" x="0px" y="0px" width="50px" height="50px" viewBox="0 0 50 50" style="enable-background:new 0 0 50 50;" xml:space="preserve" xmlns:xlink="http://www.w3.org/1999/xlink"> <style type="text/css"> .st0{fill:none;stroke:#FEB80A;stroke-width:5;stroke-miterlimit:10;} </style> <polyline class="st0" points="2.5,50 2.5,2.5 50,2.5 " /> </svg> </div> <div class="corner-detail desktop"> <svg version="1.1" id="Layer_1" x="0px" y="0px" width="100px" height="100px" viewBox="0 0 100 100" style="enable-background:new 0 0 100 100;" xml:space="preserve" xmlns:xlink="http://www.w3.org/1999/xlink"> <style type="text/css"> .st0{fill:none;stroke:#FEB80A;stroke-width:5;stroke-miterlimit:10;} </style> <polyline class="st0" points="2.5,100 2.5,2.5 100,2.5 " /> </svg> </div> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/rounded_overlay/public/2024-09/liang-ge-354x210.webp?itok=PD7j1VoO" width="354" height="210" alt="Liang Ge 354x210" class="image-style-rounded-overlay"> </div> </article> <h3 style="margin-bottom:5px;"><a href="/node/15501" data-entity-type="node" data-entity-uuid="4e2002ba-373f-4e71-ae96-c36768fd96a0" data-entity-substitution="canonical">Liang Ge, PhD</a></h3><p style="font-size:1rem;margin-top:0px;">Assistant Professor of Surgery<br>Division of Adult Cardiothoracic Surgery</p> </div> </div> </div></div> <div class="columns__item columns-col2"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <h2 style="font-size:2.25rem;margin-top:0px;">Welcome to the Cardiac Biomechanics Lab</h2><p>The Cardiac Biomechanics Laboratory is a multi-disciplinary research collaborative that investigates cardiovascular disease and intervention with state-of-the art computational techniques. The heart and cardiovascular system is one of the most complex, dynamic systems in the human body. Derangements of the left ventricle, mitral and aortic valves, and the ascending aorta impart devasting consequences on patients’ lives.</p><p>With the advancement of radiographic image processing and through experimental studies of ventricular and aortic tissue, we can construct high fidelity models of the left ventricle, aortic root, and ascending aorta offering an unprecedented degree of data. The techniques of finite element modeling, computational fluid dynamics, fluid structure interaction, and tissue biaxial testing are some of the methods our investigations employ.</p><p>Our group aims to usher in the future of cardiovascular disease research with integration of data from patient-specific models scalable to larger datasets representative of the population. We host lab space for computational and experimental studies at the San Francisco Veterans Affairs Medical Center, and collaborations exist with faculty and labs at a number of institutions around the country. Drawing from the expertise of tissue biomechanics professors, cardiothoracic surgeons and interventionalists, our group is uniquely positioned to tackle some of the most challenging issues in cardiovascular disease today.</p> </div> </div> </div></div> </div> </div> </div> </div> </div> <div class="field__item"> <div > <div class="columns paragraph paragraph--type--kan-columns paragraph--view-mode--default"> <div class="field field--name-field-heading field--type-string field--label-hidden field__item">Research</div> <div class="columns__wrap"> </div> </div> </div> </div> <div class="field__item"> <div > <div class="columns text-vert-align--top columns--layout-column-wider-left paragraph paragraph--type--kan-columns paragraph--view-mode--default"> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="text-block paragraph paragraph--type--kan-text paragraph--view-mode--default"> <div class="text-block__text"> <article 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hreflang="en">Ascending Thoracic Aortic Aneurysm and Dissection</a></div></span></div><div class="views-field views-field-body"><div class="field-content"><div class='item-research-body'> Ascending Thoracic Aortic Aneurysm and Dissection Approximately 30,000 people in the US are diagnosed with thoracic aortic aneurysms ...</div></div></div></div> <div class="research-row views-row"><div class="views-field views-field-title"><span class="field-content"><div class='item-research-title'><a href="/bi-axial-stretching-apparatus" hreflang="en">Bi-axial Stretching Apparatus</a></div></span></div><div class="views-field views-field-body"><div class="field-content"><div class='item-research-body'> Bi-axial Stretching Apparatus We utilize a custom made biaxial stretcher to determine the biaxial stiffness of certain biologic ...</div></div></div></div> <div class="research-row views-row"><div class="views-field views-field-title"><span class="field-content"><div class='item-research-title'><a href="/borderzone-dysfunction" hreflang="en">Borderzone Dysfunction</a></div></span></div><div class="views-field views-field-body"><div class="field-content"><div class='item-research-body'> Borderzone Dysfunction It has been known since the mid 1980s that systolic performance (systolic shortening and wall thickening) ...</div></div></div></div> <div class="research-row views-row"><div class="views-field views-field-title"><span class="field-content"><div class='item-research-title'><a href="/computational-simulation-transcatheter-aortic-valve-replacement-tavr" hreflang="en">Computational Simulation of Transcatheter Aortic Valve Replacement (TAVR)</a></div></span></div><div class="views-field views-field-body"><div class="field-content"><div class='item-research-body'> Computational Simulation of Transcatheter Aortic Valve Replacement (TAVR) Aortic stenosis (AS) is the most common heart valve disease ...</div></div></div></div> </div> <div class="more-link"><a href="/cardiac-biomechanics-lab-research">View All Research</a></div> </div> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div> <div class="field__item"> <div > <div class="columns text-vert-align--top columns--layout-column-wider-left paragraph paragraph--type--kan-columns paragraph--view-mode--default"> <div class="columns__wrap"> <div class="columns__item-list"> <div class="columns__item columns-col1"> <div > <div class="filtered-list paragraph paragraph--type--kan-filtered-list paragraph--view-mode--default"> <div class="filtered-list__header"> <div class="filtered-list__title"> <h2>Recent Publications</h2> </div> </div> <div class="filtered-list__view"> <div class="field field--name-kan-field-views field--type-viewsreference field--label-hidden field__item"><div class="views-element-container"><div class="node--content node__content view view-publications-for-lab view-id-publications_for_lab view-display-id-block_2 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views-field-title"><span class="field-content"><b>Comparison of Left Ventricular Function Derived from Subject-Specific Inverse Finite Element Modeling Based on 3D ECHO and Magnetic Resonance Images.</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2024 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://pubmed.ncbi.nlm.nih.gov/39061817">PubMed</a> </span></span></li> <li><span class="views-field views-field-title"><span class="field-content"><b>Temporal evolution of ascending aortic aneurysm wall stress predicts all-cause mortality.</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2024 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://pubmed.ncbi.nlm.nih.gov/38913870">PubMed</a> </span></span></li> <li><span class="views-field views-field-title"><span class="field-content"><b>Height and body surface area versus wall stress for stratification of mid-term outcomes in ascending aortic aneurysm.</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2024 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://pubmed.ncbi.nlm.nih.gov/38435381">PubMed</a> </span></span></li> <li><span class="views-field views-field-title"><span class="field-content"><b>A Simulation Study of the Effects of Number and Location of MitraClips on Mitral Regurgitation</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2023 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://researcherprofiles.org/profile/218607943">UCSF Research Profile</a> </span></span></li> <li><span class="views-field views-field-title"><span class="field-content"><b>Imaging and Computational Modeling of Tricuspid Regurgitation and Repair</b><br /></span></span><span class="views-field views-field-field-kup-publication-year"><span class="field-content">2023 | </span></span><span class="views-field views-field-field-kup-publication-id"><span class="field-content"> <a href="https://researcherprofiles.org/profile/92981458">UCSF Research Profile</a> </span></span></li> </ol> </div> </div> <div class="more-link"><a href="/cardiac-biomechanics-lab-publications">View All Publications</a></div> </div> </div> </div> </div> </div> </div></div> <div class="columns__item columns-col2"> <div > <div class="filtered-list paragraph paragraph--type--kan-filtered-list paragraph--view-mode--default"> <div class="filtered-list__header"> <div class="filtered-list__title"> <h2>Featured News</h2> </div> </div> <div class="filtered-list__view"> <div class="field 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