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id="leftbar_search_finds" class="roundedClass"> <div id="sg_leftStaticMenu"> <ul><li><img class='left-bar-icon-image' src='/media/2323572/find.gif' /><a class='item-with-icon' href='https://vascularsurgery.ucsf.edu/'>Division of Vascular Surgery</a></li><li><img class='left-bar-icon-image-default' src='/umbraco/images/umbraco/about.gif' /><a class='item-with-icon' href='https://wanglaboratory.ucsf.edu/universal-links/location--directions.aspx'>Location & Directions</a></li></ul> </div> </div>    <div id="sg_leftBarEditableRegionDiv"> <div>  <div id='sg_leftBarEditableRegion' ><div id='sg_messagebox' class='roundedClass'><h2 class='sg_message_title' style='font-weight:700;'> Principal Investigator</h2><div class='inner'><div class='div-img' style='float:left;'><img style='width:67px' border='0' src='/media/343677/rong_wang_photo.jpeg' alt='Principal Investigator' title='Principal Investigator' /></div><div class='div-text' style='float:left; width:140px; ;padding-top:4px;'><p><a href="https://wanglaboratory.ucsf.edu/people/principal-investigator/rong-wang,-phd.aspx" title="Rong Wang, Ph.D.">Rong Wang, Ph.D.<br /></a>Professor of Surgery<br /><span style="font-size: inherit;">Director, </span><span style="font-size: inherit;">Laboratory for Accelerated Vascular Research</span></p></div><div class='link_text'><a href='http://wanglab.surgery.ucsf.edu/about-the-lab.aspx'>About the Lab 禄</a></div></div><div class='bottomRounded'></div></div> <div id='sg_giftbox'><h2 class='sg_message_title' style='font-weight:700;'> Support the Lab</h2><div class='inner'><div class='make_a_gift_inner_text' style='width:168px'><p style="text-align: left;">Your gift to the Wang Lab helps scientists discover new treatments and cures for vascular diseases including stroke, ischemia, and arteriovenous malformations.</p></div><div class='link_text'><a href='https://makeagift.ucsf.edu/site/SPageServer?pagename=A1_API_GeneralGivingForm&Primary=Surgery&Other=Research of Rong Wang, Ph.D., Associate Professor of Surgery'>Make a Gift 禄</a></div></div><div class='bottomRounded'></div></div></div><div style='clear:both;display:none;'>level</div> </div>  <div class='freeform-Box-Bottom'></div> </div> </div> </div> </aside>  <div id="sg_centerContent" >   <div id="sg_contentHeading" class='lab_front_heading'> <h1 class="sg_frontPageH1"> </h1> <div class='lab_content_textarea_top'> <p><span style="color: #2d494f; font-size: 28px;">Rational Design of Cardiovascular and Cancer Therapies Through聽Molecular Control of Angiogenesis</span></p> <p>The molecular control of angiogenesis, or blood vessel growth, is critical for embryonic development, tissue regeneration, and diseases including cancer and ischemia. The long-term interest of my laboratory is to elucidate the molecular regulators of the cellular processes that occur in endothelial cells lining blood vessel walls.</p> <p>We study these questions through cell-lineage specific, temporally regulatable gene expression and deletion in mice, combined with cellular, molecular, and two-photon in vivo imaging approaches. A key challenge in the study of angiogenesis is the regulation of arterial venous hierarchy. We are currently investigating the function of Notch and ephrin-B2 signaling pathways in arterial venous specification.聽 This work may unravel signaling cascades regulating crucial vascular pathophysiology and facilitate rational design of therapies to treat cardiovascular diseases and cancer.</p> </div> </div>   <div id="sg_bottomBoxContainer"> <div class="sg_hp_2col fp-pub-news"> <script language="javascript" type="text/javascript" xmlns:user="urn:my-scripts"> function goSelectYear(which) { var nhref = which.options[which.selectedIndex].value; var resId = document.getElementById("goResearch"); var resValue = resId.options[resId.selectedIndex].value; if (resValue != "" ) window.location.href = "?ysearch=" + nhref + "&rasearch=" + resValue; else window.location.href = "?ysearch=" + nhref; } function goSelectRA(which) { var nhref = which.options[which.selectedIndex].value; var resId = document.getElementById("goYear"); var resValue = resId.options[resId.selectedIndex].value; if (resValue != "" ) window.location.href = "?rasearch=" + nhref + "&ysearch=" + resValue; else window.location.href = "?rasearch=" + nhref; } </script><h2 id="sg_frontPageH2" xmlns:user="urn:my-scripts">Recent Publications</h2><table id="pubList" xmlns:user="urn:my-scripts"><tr><td><div class="fp_labs_pubs_list"><table class='pubs-table Wang-Lab'><tr><td><ul class='fp_labs_pubs_items'><li class='fp_labs_pubs_item_container' ><div class='fp_labs_pubs_title' ><a target='_blank' href='http://www.ncbi.nlm.nih.gov/pubmed/26351360' >Mouse Models of Cerebral Arteriovenous Malformation. </a></div></li></ul></td></tr><tr><td><ul class='fp_labs_pubs_items'><li class='fp_labs_pubs_item_container' ><div class='fp_labs_pubs_title' ><a target='_blank' href='http://www.ncbi.nlm.nih.gov/pubmed/25468970' >Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels. </a></div></li></ul></td></tr><tr><td><ul class='fp_labs_pubs_items'><li class='fp_labs_pubs_item_container' ><div class='fp_labs_pubs_title' ><a target='_blank' href='http://www.ncbi.nlm.nih.gov/pubmed/24673722' >Endothelial ephrin-B2 is essential for arterial vasodilation in mice. </a></div></li></ul></td></tr><tr><td><ul class='fp_labs_pubs_items'><li class='fp_labs_pubs_item_container' ><div class='fp_labs_pubs_title' ><a target='_blank' href='http://www.ncbi.nlm.nih.gov/pubmed/25209249' >Deletion of Rbpj from postnatal endothelium leads to abnormal arteriovenous shunting in mice. </a></div></li></ul></td></tr><tr><td><ul class='fp_labs_pubs_items'><li class='fp_labs_pubs_item_container' ><div class='fp_labs_pubs_title' ><a target='_blank' href='http://www.ncbi.nlm.nih.gov/pubmed/24550118' >Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals. </a></div></li></ul></td></tr><tr><td><ul class='fp_labs_pubs_items'><li class='fp_labs_pubs_item_container' ><div class='fp_labs_pubs_title' ><a target='_blank' href='http://www.ncbi.nlm.nih.gov/pubmed/23601498' >Notch4 is required for tumor onset and perfusion. </a></div></li></ul></td></tr><tr><td><ul class='fp_labs_pubs_items'><li class='fp_labs_pubs_item_container' ><div class='fp_labs_pubs_title' ><a target='_blank' href='http://www.ncbi.nlm.nih.gov/pubmed/22261032' >Notch4 normalization reduces blood vessel size in arteriovenous malformations. </a></div></li></ul></td></tr><tr><td><ul class='fp_labs_pubs_items'><li class='fp_labs_pubs_item_container' ><div class='fp_labs_pubs_title' ><a target='_blank' href='http://www.ncbi.nlm.nih.gov/pubmed/20181926' >Inefficient skeletal muscle repair in inhibitor of differentiation knockout mice suggests a crucial role for BMP signaling during adult muscle regeneration. </a></div></li></ul></td></tr><tr><td><ul class='fp_labs_pubs_items'><li class='fp_labs_pubs_item_container' ><div class='fp_labs_pubs_title' ><a target='_blank' href='http://www.ncbi.nlm.nih.gov/pubmed/19933399' >Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice. </a></div></li></ul></td></tr><tr><td><ul class='fp_labs_pubs_items'><li class='fp_labs_pubs_item_container' ><div class='fp_labs_pubs_title' ><a target='_blank' href='http://www.ncbi.nlm.nih.gov/pubmed/19815777' >Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. </a></div></li></ul></td></tr><tr><td><ul class='fp_labs_pubs_items'><li class='fp_labs_pubs_item_container' ><div class='fp_labs_pubs_title' ><a target='_blank' href='http://www.ncbi.nlm.nih.gov/pubmed/19546852' >Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease. </a></div></li></ul></td></tr></table></div></td></tr><tr><td class="fp_labs_pubs_viewall"><a href="https://wanglaboratory.ucsf.edu/publications.aspx">View all Publications 禄</a></td></tr></table> </div> <div class="sg_hp_2col fp-pub-news"> <div id="middle_right_section"> <div id="middle_right_section_title"> <h2> News & Events </h2> </div> <table> <tr> <td> <ul class='news_frontpage_lab'> <li><a href='https://wanglaboratory.ucsf.edu/news--events/ucsf-news.aspx?id=92769/Department-of-Surgery-staff-and-faculty-receive-2022-Chancellor-Awards-for-Diversity'>Department of Surgery staff and faculty receive 2022 Chancellor Awards for Diversity</a></li><li><a href='https://wanglaboratory.ucsf.edu/news--events/ucsf-news.aspx?id=63524/Rong-Wang--Ph.D.-to-Speak-at-American-Society-for-Investigative-Pathology-(ASIP)-2016-'>Rong Wang, Ph.D. to Speak at American Society for Investigative Pathology (ASIP) 2016 </a></li><li><a href='https://wanglaboratory.ucsf.edu/news--events/ucsf-news.aspx?id=63554/Rong-Wang--Ph.D.-Gives-Plenary-Speech-at-11th-HHT-International-Scientific---Medical-Conference'>Rong Wang, Ph.D. Gives Plenary Speech at 11th HHT International Scientific & Medical Conference</a></li><li><a href='https://wanglaboratory.ucsf.edu/news--events/ucsf-news.aspx?id=63521/Rong-Wang-Delivers-Commencement-Address-at-San-Francisco-State-University'>Rong Wang Delivers Commencement Address at San Francisco State University</a></li><li><a href='https://wanglaboratory.ucsf.edu/news--events/ucsf-news.aspx?id=6568/Gene-is-Likely-Cause-of-Stroke-Inducing-Vascular-Malformations'>Gene is Likely Cause of Stroke-Inducing Vascular Malformations</a></li> </ul> <div class='news_frontpage_readmore' > <div class='news_frontpage_readmore'> <a href="https://wanglaboratory.ucsf.edu/news--events.aspx">Read all news <span class="doublearray">»</span></a> </div> </div> </td> </tr> </table> </div> </div> </div>   <div id="slideout_programs_labs_panel" class='display-none'> <form> <div id="findAProgramLabLocal" xmlns:user="urn:my-scripts"><div class="findAProgramCloseButton"><a href="#">聽</a></div><div class="findAProgramHeader"><div class="findAProgramColumnDiv robby"></div><ul 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Health Equity</a></li><li><a href='https://mindfulsurgeon.ucsf.edu/'>Center for Mindfulness in Surgery</a></li><li><a href='https://livertissueengineering.ucsf.edu/'>Chang Laboratory for Liver Tissue Engineering</a></li><li><a href='https://contelab.ucsf.edu/'>Conte Lab</a></li><li><a href='https://endocrineneoplasialab.ucsf.edu/'>Endocrine Neoplasia Research Lab</a></li><li><a href='https://itl.ucsf.edu/'>Immunogenetics & Transplantation Lab</a></li><li><a href='https://kornblithlab.ucsf.edu/'>Kornblith Lab</a></li><li><a href='https://kratzlab.ucsf.edu/'>Kratz Lab</a></li><li><a href='https://lobularbreastcancer.ucsf.edu/'>Lobular Breast Cancer Research Program</a></li><li><a href='https://mackenzielab.ucsf.edu/'>MacKenzie Lab</a></li><li><a href='https://nijagallab.ucsf.edu/'>Nijagal Lab</a></li><li><a href='#'></a></li><li><a href='https://pedsurglab.ucsf.edu/'>Pediatric Surgery Lab</a></li><li><a href='https://pomerantzlab.ucsf.edu/'>Pomerantz Lab</a></li><li><a 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