CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Mustafa Gul | Ataturk University - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="/z8r0tQiA3ZRbM97RV/V2ChFF/kLDm+z2cZyfaJTgQOb7pmpDio00bNzEzn8LcLqBxHxvXdAacCGd9NGGL+maw==" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-77f7b87cb1583fc59aa8f94756ebfe913345937eb932042b4077563bebb5fb4b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-9e8218e1301001388038e3fc3427ed00d079a4760ff7745d1ec1b2d59103170a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-b2b823dd904da60a48fd1bfa1defd840610c2ff414d3f39ed3af46277ab8df3b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-2b6f90dbd75f5941bc38f4ad716615f3ac449e7398313bb3bc225fba451cd9fa.css" /> <meta name="author" content="mustafa gul" /> <meta name="description" content="Mustafa Gul, Ataturk University: 14 Followers, 9 Following, 78 Research papers. Research interests: Sleep Medicine, Calligraphy, and Sleep and Dreaming." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = '48654d67e5106e06fb1e5c9a356c302510d6cfee'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":15279,"monthly_visitors":"125 million","monthly_visitor_count":125874410,"monthly_visitor_count_in_millions":125,"user_count":279012765,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1734537649000); window.Aedu.timeDifference = new Date().getTime() - 1734537649000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" rel="stylesheet"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-0fb6fc03c471832908791ad7ddba619b6165b3ccf7ae0f65cf933f34b0b660a7.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-772ddef14990ef25ff745ff7a68e1f5d083987771af2b9046e5dd4ece84c9e02.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-8ced32df41cb1a30061eaa13a8fe865a252f94d76a6a6a05ea0ba77c04f53a96.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://atauni.academia.edu/MustafaGul" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-77c1bbdf640d3ab9a9b87cd905f5a36d6e6aeca610cba7e42bc42af726770bbb.js" defer="defer"></script><script>Aedu.rankings = { showPaperRankingsLink: false } $viewedUser = Aedu.User.set_viewed( {"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul","photo":"/images/s65_no_pic.png","has_photo":false,"department":{"id":233665,"name":"Physiology","url":"https://atauni.academia.edu/Departments/Physiology/Documents","university":{"id":1687,"name":"Ataturk University","url":"https://atauni.academia.edu/"}},"position":"Faculty Member","position_id":1,"is_analytics_public":false,"interests":[{"id":14498,"name":"Sleep Medicine","url":"https://www.academia.edu/Documents/in/Sleep_Medicine"},{"id":31154,"name":"Calligraphy","url":"https://www.academia.edu/Documents/in/Calligraphy"},{"id":74543,"name":"Sleep and Dreaming","url":"https://www.academia.edu/Documents/in/Sleep_and_Dreaming"},{"id":31957,"name":"COPD (Pulmonary Research)","url":"https://www.academia.edu/Documents/in/COPD_Pulmonary_Research_"},{"id":165415,"name":"Medical Biochemistry","url":"https://www.academia.edu/Documents/in/Medical_Biochemistry"},{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://atauni.academia.edu/MustafaGul","location":"/MustafaGul","scheme":"https","host":"atauni.academia.edu","port":null,"pathname":"/MustafaGul","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-d507da9d-784f-44f4-8c0e-cb2d2c140a91"></div> <div id="ProfileCheckPaperUpdate-react-component-d507da9d-784f-44f4-8c0e-cb2d2c140a91"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Mustafa Gul</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://atauni.academia.edu/">Ataturk University</a>, <a class="u-tcGrayDarker" href="https://atauni.academia.edu/Departments/Physiology/Documents">Physiology</a>, <span class="u-tcGrayDarker">Faculty Member</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Mustafa" data-follow-user-id="32891153" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="32891153"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">14</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">9</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">8</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span><a class="ri-more-link js-profile-ri-list-card" data-click-track="profile-user-info-primary-research-interest" data-has-card-for-ri-list="32891153">View All (6)</a></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32891153" href="https://www.academia.edu/Documents/in/Sleep_Medicine"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://atauni.academia.edu/MustafaGul","location":"/MustafaGul","scheme":"https","host":"atauni.academia.edu","port":null,"pathname":"/MustafaGul","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Sleep Medicine"]}" data-trace="false" data-dom-id="Pill-react-component-c005960f-633e-4fd4-9f17-c6ce4dc40291"></div> <div id="Pill-react-component-c005960f-633e-4fd4-9f17-c6ce4dc40291"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32891153" href="https://www.academia.edu/Documents/in/Calligraphy"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Calligraphy"]}" data-trace="false" data-dom-id="Pill-react-component-e11e1b8d-322a-4deb-bced-600cefef4f59"></div> <div id="Pill-react-component-e11e1b8d-322a-4deb-bced-600cefef4f59"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32891153" href="https://www.academia.edu/Documents/in/Sleep_and_Dreaming"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Sleep and Dreaming"]}" data-trace="false" data-dom-id="Pill-react-component-3957fc7c-c8fc-4667-9845-be0831fa7637"></div> <div id="Pill-react-component-3957fc7c-c8fc-4667-9845-be0831fa7637"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32891153" href="https://www.academia.edu/Documents/in/COPD_Pulmonary_Research_"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["COPD (Pulmonary Research)"]}" data-trace="false" data-dom-id="Pill-react-component-cb756977-d358-4f44-9074-cc3fc406aa83"></div> <div id="Pill-react-component-cb756977-d358-4f44-9074-cc3fc406aa83"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32891153" href="https://www.academia.edu/Documents/in/Medical_Biochemistry"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Medical Biochemistry"]}" data-trace="false" data-dom-id="Pill-react-component-31dcffdd-c865-468c-a296-382cc12dc694"></div> <div id="Pill-react-component-31dcffdd-c865-468c-a296-382cc12dc694"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Mustafa Gul</h3></div><div class="js-work-strip profile--work_container" data-work-id="115164667"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115164667/Sporti_f_Performans_%C4%B0%C3%A7i_n_Opti_mal_V%C3%BCcut_A%C4%9Firli%C4%9Fi"><img alt="Research paper thumbnail of Sporti̇f Performans İçi̇n Opti̇mal Vücut Ağirliği" class="work-thumbnail" src="https://attachments.academia-assets.com/111653223/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115164667/Sporti_f_Performans_%C4%B0%C3%A7i_n_Opti_mal_V%C3%BCcut_A%C4%9Firli%C4%9Fi">Sporti̇f Performans İçi̇n Opti̇mal Vücut Ağirliği</a></div><div class="wp-workCard_item"><span>Journal of Physical Education and Sport Sciences</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6c846dd204ea9693a9567ca5496ba960" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111653223,"asset_id":115164667,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111653223/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115164667"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115164667"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115164667; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115164667]").text(description); $(".js-view-count[data-work-id=115164667]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115164667; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115164667']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115164667, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6c846dd204ea9693a9567ca5496ba960" } } $('.js-work-strip[data-work-id=115164667]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115164667,"title":"Sporti̇f Performans İçi̇n Opti̇mal Vücut Ağirliği","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Journal of Physical Education and Sport Sciences"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115164667/Sporti_f_Performans_%C4%B0%C3%A7i_n_Opti_mal_V%C3%BCcut_A%C4%9Firli%C4%9Fi","translated_internal_url":"","created_at":"2024-02-20T05:01:26.718-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":111653223,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111653223/thumbnails/1.jpg","file_name":"297272.pdf","download_url":"https://www.academia.edu/attachments/111653223/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Sporti_f_Performans_Ici_n_Opti_mal_Vucut.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111653223/297272-libre.pdf?1708438141=\u0026response-content-disposition=attachment%3B+filename%3DSporti_f_Performans_Ici_n_Opti_mal_Vucut.pdf\u0026Expires=1734541248\u0026Signature=IUpEcOiTQDePAP0dA7~2DOshG96B2woOqLqb-TLzGaYMPBcOpT1jPArXln8YkfsqCjL-U3jn5htU3blsi3kefM754e5FfGPj2xYJVsQ0TNcmoMFVCchGE051UrF9oARZhuIXkLG3oBlPkHZLmdyvZ7QvoF2GyRH5SU3dNGGDXkbq7qC7IL6w6l8QHeGEP5GX4JY1rLsgPmhGsc3gWWZQmp1AMrMhWdMH6x9PUD9Cgyw7gBjduJzMLQ0T3IurrKt7mFzJ~e9bPBWwqoFndvoJF1dn8pKrDSTUN0UoyFvcKxEQE5A01kDDOliQQHIgVStSCJDdpbfaaaAMge5aHDi5GA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Sporti_f_Performans_İçi_n_Opti_mal_Vücut_Ağirliği","translated_slug":"","page_count":4,"language":"tr","content_type":"Work","summary":null,"owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":111653223,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111653223/thumbnails/1.jpg","file_name":"297272.pdf","download_url":"https://www.academia.edu/attachments/111653223/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Sporti_f_Performans_Ici_n_Opti_mal_Vucut.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111653223/297272-libre.pdf?1708438141=\u0026response-content-disposition=attachment%3B+filename%3DSporti_f_Performans_Ici_n_Opti_mal_Vucut.pdf\u0026Expires=1734541248\u0026Signature=IUpEcOiTQDePAP0dA7~2DOshG96B2woOqLqb-TLzGaYMPBcOpT1jPArXln8YkfsqCjL-U3jn5htU3blsi3kefM754e5FfGPj2xYJVsQ0TNcmoMFVCchGE051UrF9oARZhuIXkLG3oBlPkHZLmdyvZ7QvoF2GyRH5SU3dNGGDXkbq7qC7IL6w6l8QHeGEP5GX4JY1rLsgPmhGsc3gWWZQmp1AMrMhWdMH6x9PUD9Cgyw7gBjduJzMLQ0T3IurrKt7mFzJ~e9bPBWwqoFndvoJF1dn8pKrDSTUN0UoyFvcKxEQE5A01kDDOliQQHIgVStSCJDdpbfaaaAMge5aHDi5GA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":39633504,"url":"http://e-dergi.atauni.edu.tr/ataunibesyo/article/download/1025000782/1025000754"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110470283"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110470283/Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction"><img alt="Research paper thumbnail of Investigation of Serum NO, ADMA and Apelin Levels in Thyroid Dysfunction" class="work-thumbnail" src="https://attachments.academia-assets.com/108277733/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110470283/Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction">Investigation of Serum NO, ADMA and Apelin Levels in Thyroid Dysfunction</a></div><div class="wp-workCard_item"><span>Journal of Medicine, Physiology and Biophysics</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Thyroid gland diseases are among the most common endocrine diseases and still continue to be an i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Thyroid gland diseases are among the most common endocrine diseases and still continue to be an important health problem especially in developing countries. It was aimed to investigate serum NO, ADMA and Apelin levels in patients with thyroid dysfunction. This study was conducted with 150 thyroid patients and 50 healthy subjects. Study subjects were divided into three groups; control (n=50), hyperthyroid (n=75) and hypothyroid (n=75). Serum TSH, FT3, FT4 levels were measured by chemiluminescence method NO level were measured by spectrophotometric method, ADMA and apelin levels were measured by ELISA. Serum NO levels were higher in hypothyroid group than in hyperthyroid group, and the difference was statistically significant. Serum ADMA levels of the hyperthyroid group were significantly higher than the other two groups and the difference was statistically significant. The levels of serum apelin were statistically significantly higher in the hyperthyroid group than the other two groups. In patients with hyperthyroidism, ADMA and Apelin levels were higher, while NO level was lower. However, NO level was higher in patients with hypothyroidims than the other two groups. Apelin, which has been emphasized as a preventive and therapeutic agent particularly for the cardiovascular system, might have increased in hyperthyroid patients, regardless of NO, to protect cardiovascular system from possible adverse effects of ADMA.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1565e3921813a81977b23da4929582bd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108277733,"asset_id":110470283,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108277733/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110470283"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110470283"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110470283; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110470283]").text(description); $(".js-view-count[data-work-id=110470283]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110470283; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110470283']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110470283, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1565e3921813a81977b23da4929582bd" } } $('.js-work-strip[data-work-id=110470283]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110470283,"title":"Investigation of Serum NO, ADMA and Apelin Levels in Thyroid Dysfunction","translated_title":"","metadata":{"publisher":"International Institute for Science, Technology and Education","grobid_abstract":"Thyroid gland diseases are among the most common endocrine diseases and still continue to be an important health problem especially in developing countries. It was aimed to investigate serum NO, ADMA and Apelin levels in patients with thyroid dysfunction. This study was conducted with 150 thyroid patients and 50 healthy subjects. Study subjects were divided into three groups; control (n=50), hyperthyroid (n=75) and hypothyroid (n=75). Serum TSH, FT3, FT4 levels were measured by chemiluminescence method NO level were measured by spectrophotometric method, ADMA and apelin levels were measured by ELISA. Serum NO levels were higher in hypothyroid group than in hyperthyroid group, and the difference was statistically significant. Serum ADMA levels of the hyperthyroid group were significantly higher than the other two groups and the difference was statistically significant. The levels of serum apelin were statistically significantly higher in the hyperthyroid group than the other two groups. In patients with hyperthyroidism, ADMA and Apelin levels were higher, while NO level was lower. However, NO level was higher in patients with hypothyroidims than the other two groups. Apelin, which has been emphasized as a preventive and therapeutic agent particularly for the cardiovascular system, might have increased in hyperthyroid patients, regardless of NO, to protect cardiovascular system from possible adverse effects of ADMA.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Journal of Medicine, Physiology and Biophysics","grobid_abstract_attachment_id":108277733},"translated_abstract":null,"internal_url":"https://www.academia.edu/110470283/Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction","translated_internal_url":"","created_at":"2023-12-03T12:58:01.826-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":108277733,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108277733/thumbnails/1.jpg","file_name":"Sahin_et_al._Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction_2020.pdf","download_url":"https://www.academia.edu/attachments/108277733/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Investigation_of_Serum_NO_ADMA_and_Apeli.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108277733/Sahin_et_al._Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction_2020-libre.pdf?1701638128=\u0026response-content-disposition=attachment%3B+filename%3DInvestigation_of_Serum_NO_ADMA_and_Apeli.pdf\u0026Expires=1734541248\u0026Signature=V2xC-jN91tWpKiVQV1eE4K7Cy50OF3empgxUtThINqFUC-Hc~OXc-fgmLNZW6PJu7o1YKonzQP5q3V7LuO5uLNIll87VteVgzniv62amkZJ3HD7~zx8hDYlXVo-lIzuZWyb1SKHNSY4uqKuseoDBHomCdhQTrTATVZA-lzMXZ1cVZ9VUWkUxsFQo-uIRr73aolM198zABqyM6IJcjXWIdjtt-wA8D2YFlNhhW~vFrGGbSit4-v8FMiGY09Iq~X~3Dzcp1ozi3HmvlUYM1pA~ZSW0K3fbDIuAz~jL5vDnvvl6hG1Qo~Ps2xdWK1sY1mrGFxgAFFg5soN1pEs03FqGjQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction","translated_slug":"","page_count":7,"language":"en","content_type":"Work","summary":"Thyroid gland diseases are among the most common endocrine diseases and still continue to be an important health problem especially in developing countries. It was aimed to investigate serum NO, ADMA and Apelin levels in patients with thyroid dysfunction. This study was conducted with 150 thyroid patients and 50 healthy subjects. Study subjects were divided into three groups; control (n=50), hyperthyroid (n=75) and hypothyroid (n=75). Serum TSH, FT3, FT4 levels were measured by chemiluminescence method NO level were measured by spectrophotometric method, ADMA and apelin levels were measured by ELISA. Serum NO levels were higher in hypothyroid group than in hyperthyroid group, and the difference was statistically significant. Serum ADMA levels of the hyperthyroid group were significantly higher than the other two groups and the difference was statistically significant. The levels of serum apelin were statistically significantly higher in the hyperthyroid group than the other two groups. In patients with hyperthyroidism, ADMA and Apelin levels were higher, while NO level was lower. However, NO level was higher in patients with hypothyroidims than the other two groups. Apelin, which has been emphasized as a preventive and therapeutic agent particularly for the cardiovascular system, might have increased in hyperthyroid patients, regardless of NO, to protect cardiovascular system from possible adverse effects of ADMA.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":108277733,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108277733/thumbnails/1.jpg","file_name":"Sahin_et_al._Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction_2020.pdf","download_url":"https://www.academia.edu/attachments/108277733/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Investigation_of_Serum_NO_ADMA_and_Apeli.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108277733/Sahin_et_al._Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction_2020-libre.pdf?1701638128=\u0026response-content-disposition=attachment%3B+filename%3DInvestigation_of_Serum_NO_ADMA_and_Apeli.pdf\u0026Expires=1734541248\u0026Signature=V2xC-jN91tWpKiVQV1eE4K7Cy50OF3empgxUtThINqFUC-Hc~OXc-fgmLNZW6PJu7o1YKonzQP5q3V7LuO5uLNIll87VteVgzniv62amkZJ3HD7~zx8hDYlXVo-lIzuZWyb1SKHNSY4uqKuseoDBHomCdhQTrTATVZA-lzMXZ1cVZ9VUWkUxsFQo-uIRr73aolM198zABqyM6IJcjXWIdjtt-wA8D2YFlNhhW~vFrGGbSit4-v8FMiGY09Iq~X~3Dzcp1ozi3HmvlUYM1pA~ZSW0K3fbDIuAz~jL5vDnvvl6hG1Qo~Ps2xdWK1sY1mrGFxgAFFg5soN1pEs03FqGjQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":30649,"name":"Thyroid","url":"https://www.academia.edu/Documents/in/Thyroid"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":976254,"name":"Serum Asymmetric Dimethylarginine (ADMA)","url":"https://www.academia.edu/Documents/in/Serum_Asymmetric_Dimethylarginine_ADMA_"},{"id":1139929,"name":"Apelin","url":"https://www.academia.edu/Documents/in/Apelin"},{"id":1641959,"name":"Thyroid Dysfunction","url":"https://www.academia.edu/Documents/in/Thyroid_Dysfunction"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110469999"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110469999/Hippophae_rhamnoides_attenuates_nicotine_induced_oxidative_stress_in_rat_liver"><img alt="Research paper thumbnail of Hippophae rhamnoides attenuates nicotine-induced oxidative stress in rat liver" class="work-thumbnail" src="https://attachments.academia-assets.com/108366128/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110469999/Hippophae_rhamnoides_attenuates_nicotine_induced_oxidative_stress_in_rat_liver">Hippophae rhamnoides attenuates nicotine-induced oxidative stress in rat liver</a></div><div class="wp-workCard_item"><span>Pharmaceutical Biology</span><span>, Apr 19, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The effects of vitamin E and Hippophae rhamnoides L. (Elaeagnaceae) extract (HRe-1) on nicotine-i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The effects of vitamin E and Hippophae rhamnoides L. (Elaeagnaceae) extract (HRe-1) on nicotine-induced oxidative stress in rat liver were investigated. Four groups, eight rats each, were used in this study, and the supplementation period was 3 weeks. The groups were: nicotine (0.5 mg/kg/day, intraperitoneal (i.p.)); nicotine plus vitamin E (75 mg/kg/day, intragastric (i.g.)); nicotine plus HRe-1 (250 mg/kg/day, i.g.); and the control group. The malondialdehyde and nitric oxide levels, glutathione peroxidase, glutathione S-transferase, glutathione reductase, superoxide dismutase, and total and non-enzymatic superoxide scavenger activities were measured spectrophotometrically in supernatants of the tissue homogenates. Nicotine increased the malondialdehyde level in liver tissue compared with control. This nicotine-induced increase in lipid peroxidation was prevented by both vitamin E and HRe-1. Superoxide dismutase activity was higher in the nicotine plus vitamin E-supplemented group compared with nicotine and control groups. Glutathione reductase activity was higher in the nicotine group compared with the control group. However, glutathione peroxidase activity in the control group was higher than the levels in the nicotine, and the nicotine plus HRe-1 supplemented groups. The nitric oxide level was higher in the nicotine group compared with all other groups. Total and non-enzymatic superoxide scavenger activities and glutathione S-transferase activity were not affected by any of the treatments. Our results suggest that Hippophae rhamnoides extract as well as vitamin E can protect the liver against nicotine-induced oxidative stress.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="49a3267eecd6f89942ab071fe91b7b1b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108366128,"asset_id":110469999,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108366128/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110469999"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110469999"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110469999; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110469999]").text(description); $(".js-view-count[data-work-id=110469999]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110469999; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110469999']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110469999, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "49a3267eecd6f89942ab071fe91b7b1b" } } $('.js-work-strip[data-work-id=110469999]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110469999,"title":"Hippophae rhamnoides attenuates nicotine-induced oxidative stress in rat liver","translated_title":"","metadata":{"abstract":"The effects of vitamin E and Hippophae rhamnoides L. (Elaeagnaceae) extract (HRe-1) on nicotine-induced oxidative stress in rat liver were investigated. Four groups, eight rats each, were used in this study, and the supplementation period was 3 weeks. The groups were: nicotine (0.5 mg/kg/day, intraperitoneal (i.p.)); nicotine plus vitamin E (75 mg/kg/day, intragastric (i.g.)); nicotine plus HRe-1 (250 mg/kg/day, i.g.); and the control group. The malondialdehyde and nitric oxide levels, glutathione peroxidase, glutathione S-transferase, glutathione reductase, superoxide dismutase, and total and non-enzymatic superoxide scavenger activities were measured spectrophotometrically in supernatants of the tissue homogenates. Nicotine increased the malondialdehyde level in liver tissue compared with control. This nicotine-induced increase in lipid peroxidation was prevented by both vitamin E and HRe-1. Superoxide dismutase activity was higher in the nicotine plus vitamin E-supplemented group compared with nicotine and control groups. Glutathione reductase activity was higher in the nicotine group compared with the control group. However, glutathione peroxidase activity in the control group was higher than the levels in the nicotine, and the nicotine plus HRe-1 supplemented groups. The nitric oxide level was higher in the nicotine group compared with all other groups. Total and non-enzymatic superoxide scavenger activities and glutathione S-transferase activity were not affected by any of the treatments. Our results suggest that Hippophae rhamnoides extract as well as vitamin E can protect the liver against nicotine-induced oxidative stress.","publisher":"Taylor \u0026 Francis","publication_date":{"day":19,"month":4,"year":2010,"errors":{}},"publication_name":"Pharmaceutical Biology"},"translated_abstract":"The effects of vitamin E and Hippophae rhamnoides L. (Elaeagnaceae) extract (HRe-1) on nicotine-induced oxidative stress in rat liver were investigated. Four groups, eight rats each, were used in this study, and the supplementation period was 3 weeks. The groups were: nicotine (0.5 mg/kg/day, intraperitoneal (i.p.)); nicotine plus vitamin E (75 mg/kg/day, intragastric (i.g.)); nicotine plus HRe-1 (250 mg/kg/day, i.g.); and the control group. The malondialdehyde and nitric oxide levels, glutathione peroxidase, glutathione S-transferase, glutathione reductase, superoxide dismutase, and total and non-enzymatic superoxide scavenger activities were measured spectrophotometrically in supernatants of the tissue homogenates. Nicotine increased the malondialdehyde level in liver tissue compared with control. This nicotine-induced increase in lipid peroxidation was prevented by both vitamin E and HRe-1. Superoxide dismutase activity was higher in the nicotine plus vitamin E-supplemented group compared with nicotine and control groups. Glutathione reductase activity was higher in the nicotine group compared with the control group. However, glutathione peroxidase activity in the control group was higher than the levels in the nicotine, and the nicotine plus HRe-1 supplemented groups. The nitric oxide level was higher in the nicotine group compared with all other groups. Total and non-enzymatic superoxide scavenger activities and glutathione S-transferase activity were not affected by any of the treatments. Our results suggest that Hippophae rhamnoides extract as well as vitamin E can protect the liver against nicotine-induced oxidative stress.","internal_url":"https://www.academia.edu/110469999/Hippophae_rhamnoides_attenuates_nicotine_induced_oxidative_stress_in_rat_liver","translated_internal_url":"","created_at":"2023-12-03T12:54:28.120-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":108366128,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108366128/thumbnails/1.jpg","file_name":"Taysi_et_al._Pharmaceutical_Biology_2010.pdf","download_url":"https://www.academia.edu/attachments/108366128/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Hippophae_rhamnoides_attenuates_nicotine.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108366128/Taysi_et_al._Pharmaceutical_Biology_2010-libre.pdf?1701759641=\u0026response-content-disposition=attachment%3B+filename%3DHippophae_rhamnoides_attenuates_nicotine.pdf\u0026Expires=1734541248\u0026Signature=Ebg5zYALaEL~Fqa10qPZKfcOWdqX9wlBbRl5ElCLJXZXewidXmdt2u-ntZx8EfGnzdYzRqJy5mJxCGXmT663Od7z1JV5MuAIBzZzLR1zKRM37FC0c-KepEYOGWCjy17ljCc9cgXGmor6Ua3IONHatW6qmlOfmTJipGNI7f4MThuqpmin1~MZvMAmNZ3FrL97TqkvF8pBPt0Mvcv6~8sh6JYCMYX9y8TrLCAv9RkajB-Fgyrc5RJe9Cv5bCK3JRDHzqmB974ADu7sBSU2tU5aPi1kuXAevZ1WzUNjSOLcbQf64N2~c4htJhQdpVVTE22l~kVhCLWdXxRrNqYIp6-xVQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Hippophae_rhamnoides_attenuates_nicotine_induced_oxidative_stress_in_rat_liver","translated_slug":"","page_count":6,"language":"en","content_type":"Work","summary":"The effects of vitamin E and Hippophae rhamnoides L. (Elaeagnaceae) extract (HRe-1) on nicotine-induced oxidative stress in rat liver were investigated. Four groups, eight rats each, were used in this study, and the supplementation period was 3 weeks. The groups were: nicotine (0.5 mg/kg/day, intraperitoneal (i.p.)); nicotine plus vitamin E (75 mg/kg/day, intragastric (i.g.)); nicotine plus HRe-1 (250 mg/kg/day, i.g.); and the control group. The malondialdehyde and nitric oxide levels, glutathione peroxidase, glutathione S-transferase, glutathione reductase, superoxide dismutase, and total and non-enzymatic superoxide scavenger activities were measured spectrophotometrically in supernatants of the tissue homogenates. Nicotine increased the malondialdehyde level in liver tissue compared with control. This nicotine-induced increase in lipid peroxidation was prevented by both vitamin E and HRe-1. Superoxide dismutase activity was higher in the nicotine plus vitamin E-supplemented group compared with nicotine and control groups. Glutathione reductase activity was higher in the nicotine group compared with the control group. However, glutathione peroxidase activity in the control group was higher than the levels in the nicotine, and the nicotine plus HRe-1 supplemented groups. The nitric oxide level was higher in the nicotine group compared with all other groups. Total and non-enzymatic superoxide scavenger activities and glutathione S-transferase activity were not affected by any of the treatments. Our results suggest that Hippophae rhamnoides extract as well as vitamin E can protect the liver against nicotine-induced oxidative stress.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":108366128,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108366128/thumbnails/1.jpg","file_name":"Taysi_et_al._Pharmaceutical_Biology_2010.pdf","download_url":"https://www.academia.edu/attachments/108366128/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Hippophae_rhamnoides_attenuates_nicotine.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108366128/Taysi_et_al._Pharmaceutical_Biology_2010-libre.pdf?1701759641=\u0026response-content-disposition=attachment%3B+filename%3DHippophae_rhamnoides_attenuates_nicotine.pdf\u0026Expires=1734541248\u0026Signature=Ebg5zYALaEL~Fqa10qPZKfcOWdqX9wlBbRl5ElCLJXZXewidXmdt2u-ntZx8EfGnzdYzRqJy5mJxCGXmT663Od7z1JV5MuAIBzZzLR1zKRM37FC0c-KepEYOGWCjy17ljCc9cgXGmor6Ua3IONHatW6qmlOfmTJipGNI7f4MThuqpmin1~MZvMAmNZ3FrL97TqkvF8pBPt0Mvcv6~8sh6JYCMYX9y8TrLCAv9RkajB-Fgyrc5RJe9Cv5bCK3JRDHzqmB974ADu7sBSU2tU5aPi1kuXAevZ1WzUNjSOLcbQf64N2~c4htJhQdpVVTE22l~kVhCLWdXxRrNqYIp6-xVQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver"},{"id":91360,"name":"Nicotine","url":"https://www.academia.edu/Documents/in/Nicotine"},{"id":95655,"name":"Pharmaceutical","url":"https://www.academia.edu/Documents/in/Pharmaceutical"},{"id":118450,"name":"Glutathione","url":"https://www.academia.edu/Documents/in/Glutathione"},{"id":141395,"name":"Glutathione Peroxidase","url":"https://www.academia.edu/Documents/in/Glutathione_Peroxidase"},{"id":160814,"name":"Fruit","url":"https://www.academia.edu/Documents/in/Fruit"},{"id":233372,"name":"Lipid peroxidation","url":"https://www.academia.edu/Documents/in/Lipid_peroxidation"},{"id":308667,"name":"Pharmaceutical Biology","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Biology"},{"id":354056,"name":"Plant extracts","url":"https://www.academia.edu/Documents/in/Plant_extracts"},{"id":1011463,"name":"Glutathione Reductase","url":"https://www.academia.edu/Documents/in/Glutathione_Reductase"},{"id":1108282,"name":"Hippophae","url":"https://www.academia.edu/Documents/in/Hippophae"},{"id":1446339,"name":"Malondialdehyde","url":"https://www.academia.edu/Documents/in/Malondialdehyde"},{"id":2463495,"name":"Random Allocation","url":"https://www.academia.edu/Documents/in/Random_Allocation"},{"id":3194331,"name":"Rat Liver","url":"https://www.academia.edu/Documents/in/Rat_Liver"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":36368365,"url":"https://doi.org/10.3109/13880200903179707"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105228595"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105228595/Effects_of_endurance_training_on_tissue_glutathione_homeostasis_and_lipid_peroxidation_in_streptozotocin_induced_diabetic_rats"><img alt="Research paper thumbnail of Effects of endurance training on tissue glutathione homeostasis and lipid peroxidation in streptozotocin-induced diabetic rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105228595/Effects_of_endurance_training_on_tissue_glutathione_homeostasis_and_lipid_peroxidation_in_streptozotocin_induced_diabetic_rats">Effects of endurance training on tissue glutathione homeostasis and lipid peroxidation in streptozotocin-induced diabetic rats</a></div><div class="wp-workCard_item"><span>Scandinavian Journal of Medicine &amp; Science in Sports</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aims of our study were to assess whether endurance training strengthens glutathione-dependent...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aims of our study were to assess whether endurance training strengthens glutathione-dependent antioxidant defenses and decreases oxidative stress in experimental diabetes. Streptozotocin-induced diabetic rats were divided into trained and untrained groups, which were further divided into resting and acute exercise groups. Endurance training consisted of treadmill running for 8 weeks. For acute exhaustive exercise, graded treadmill running was conducted until exhaustion. Eight weeks&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; treadmill training increased the endurance, favorably decreased lipid peroxidation as measured by thiobarbituric acid reactive substances but not conjugated dienes levels in kidney and vastus lateralis muscle and upregulated glutathione peroxidase in red gastrocnemius muscle. However, it adversely decreased total glutathione level and glutathione peroxidase activity in kidney. Acute exhaustive exercise up-regulated glutathione peroxidase activity in liver. Endurance training did not prevent the increase in thiobarbituric acid reactive substances level in liver due to acute exhaustive exercise. Activities of glutathione disulfide reductase and glutathione S-transferase were not affected. Even though endurance training appeared to upregulate glutathione dependent antioxidant defense in skeletal muscle and to decrease lipid peroxidation in kidney and vastus lateralis muscle as measured by TBARS, our results suggests that beneficial effects of 8 weeks of endurance training are limited in this rat model of uncontrolled diabetes mellitus.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105228595"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105228595"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105228595; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105228595]").text(description); $(".js-view-count[data-work-id=105228595]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105228595; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105228595']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105228595, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105228595]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105228595,"title":"Effects of endurance training on tissue glutathione homeostasis and lipid peroxidation in streptozotocin-induced diabetic rats","translated_title":"","metadata":{"abstract":"The aims of our study were to assess whether endurance training strengthens glutathione-dependent antioxidant defenses and decreases oxidative stress in experimental diabetes. Streptozotocin-induced diabetic rats were divided into trained and untrained groups, which were further divided into resting and acute exercise groups. Endurance training consisted of treadmill running for 8 weeks. For acute exhaustive exercise, graded treadmill running was conducted until exhaustion. Eight weeks\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; treadmill training increased the endurance, favorably decreased lipid peroxidation as measured by thiobarbituric acid reactive substances but not conjugated dienes levels in kidney and vastus lateralis muscle and upregulated glutathione peroxidase in red gastrocnemius muscle. However, it adversely decreased total glutathione level and glutathione peroxidase activity in kidney. Acute exhaustive exercise up-regulated glutathione peroxidase activity in liver. Endurance training did not prevent the increase in thiobarbituric acid reactive substances level in liver due to acute exhaustive exercise. Activities of glutathione disulfide reductase and glutathione S-transferase were not affected. Even though endurance training appeared to upregulate glutathione dependent antioxidant defense in skeletal muscle and to decrease lipid peroxidation in kidney and vastus lateralis muscle as measured by TBARS, our results suggests that beneficial effects of 8 weeks of endurance training are limited in this rat model of uncontrolled diabetes mellitus.","publisher":"Wiley","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Scandinavian Journal of Medicine \u0026amp; Science in Sports"},"translated_abstract":"The aims of our study were to assess whether endurance training strengthens glutathione-dependent antioxidant defenses and decreases oxidative stress in experimental diabetes. Streptozotocin-induced diabetic rats were divided into trained and untrained groups, which were further divided into resting and acute exercise groups. Endurance training consisted of treadmill running for 8 weeks. For acute exhaustive exercise, graded treadmill running was conducted until exhaustion. Eight weeks\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; treadmill training increased the endurance, favorably decreased lipid peroxidation as measured by thiobarbituric acid reactive substances but not conjugated dienes levels in kidney and vastus lateralis muscle and upregulated glutathione peroxidase in red gastrocnemius muscle. However, it adversely decreased total glutathione level and glutathione peroxidase activity in kidney. Acute exhaustive exercise up-regulated glutathione peroxidase activity in liver. Endurance training did not prevent the increase in thiobarbituric acid reactive substances level in liver due to acute exhaustive exercise. Activities of glutathione disulfide reductase and glutathione S-transferase were not affected. Even though endurance training appeared to upregulate glutathione dependent antioxidant defense in skeletal muscle and to decrease lipid peroxidation in kidney and vastus lateralis muscle as measured by TBARS, our results suggests that beneficial effects of 8 weeks of endurance training are limited in this rat model of uncontrolled diabetes mellitus.","internal_url":"https://www.academia.edu/105228595/Effects_of_endurance_training_on_tissue_glutathione_homeostasis_and_lipid_peroxidation_in_streptozotocin_induced_diabetic_rats","translated_internal_url":"","created_at":"2023-08-03T13:23:05.650-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effects_of_endurance_training_on_tissue_glutathione_homeostasis_and_lipid_peroxidation_in_streptozotocin_induced_diabetic_rats","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The aims of our study were to assess whether endurance training strengthens glutathione-dependent antioxidant defenses and decreases oxidative stress in experimental diabetes. Streptozotocin-induced diabetic rats were divided into trained and untrained groups, which were further divided into resting and acute exercise groups. Endurance training consisted of treadmill running for 8 weeks. For acute exhaustive exercise, graded treadmill running was conducted until exhaustion. Eight weeks\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; treadmill training increased the endurance, favorably decreased lipid peroxidation as measured by thiobarbituric acid reactive substances but not conjugated dienes levels in kidney and vastus lateralis muscle and upregulated glutathione peroxidase in red gastrocnemius muscle. However, it adversely decreased total glutathione level and glutathione peroxidase activity in kidney. Acute exhaustive exercise up-regulated glutathione peroxidase activity in liver. Endurance training did not prevent the increase in thiobarbituric acid reactive substances level in liver due to acute exhaustive exercise. Activities of glutathione disulfide reductase and glutathione S-transferase were not affected. Even though endurance training appeared to upregulate glutathione dependent antioxidant defense in skeletal muscle and to decrease lipid peroxidation in kidney and vastus lateralis muscle as measured by TBARS, our results suggests that beneficial effects of 8 weeks of endurance training are limited in this rat model of uncontrolled diabetes mellitus.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":4228,"name":"Skeletal muscle biology","url":"https://www.academia.edu/Documents/in/Skeletal_muscle_biology"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver"},{"id":103339,"name":"Antioxidant","url":"https://www.academia.edu/Documents/in/Antioxidant"},{"id":118450,"name":"Glutathione","url":"https://www.academia.edu/Documents/in/Glutathione"},{"id":141395,"name":"Glutathione Peroxidase","url":"https://www.academia.edu/Documents/in/Glutathione_Peroxidase"},{"id":233372,"name":"Lipid peroxidation","url":"https://www.academia.edu/Documents/in/Lipid_peroxidation"},{"id":357849,"name":"Skeletal Muscle","url":"https://www.academia.edu/Documents/in/Skeletal_Muscle"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":379889,"name":"Homeostasis","url":"https://www.academia.edu/Documents/in/Homeostasis"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance"},{"id":846529,"name":"Endurance Training","url":"https://www.academia.edu/Documents/in/Endurance_Training"},{"id":1011463,"name":"Glutathione Reductase","url":"https://www.academia.edu/Documents/in/Glutathione_Reductase"},{"id":1031967,"name":"Diabetic Rat","url":"https://www.academia.edu/Documents/in/Diabetic_Rat"}],"urls":[{"id":33230813,"url":"http://onlinelibrary.wiley.com/wol1/doi/10.1034/j.1600-0838.2002.120307.x/fullpdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105228594"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105228594/_Lipoic_Acid_Supplementation_in_Exercise"><img alt="Research paper thumbnail of ??-Lipoic Acid Supplementation in Exercise" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105228594/_Lipoic_Acid_Supplementation_in_Exercise">??-Lipoic Acid Supplementation in Exercise</a></div><div class="wp-workCard_item"><span>Medicine & Science in Sports & Exercise</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105228594"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105228594"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105228594; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105228594]").text(description); $(".js-view-count[data-work-id=105228594]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105228594; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105228594']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105228594, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105228594]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105228594,"title":"??-Lipoic Acid Supplementation in Exercise","translated_title":"","metadata":{"publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Medicine \u0026 Science in Sports \u0026 Exercise"},"translated_abstract":null,"internal_url":"https://www.academia.edu/105228594/_Lipoic_Acid_Supplementation_in_Exercise","translated_internal_url":"","created_at":"2023-08-03T13:23:05.500-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_Lipoic_Acid_Supplementation_in_Exercise","translated_slug":"","page_count":null,"language":"fr","content_type":"Work","summary":null,"owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":424010,"name":"Alpha Lipoic Acid","url":"https://www.academia.edu/Documents/in/Alpha_Lipoic_Acid"},{"id":992395,"name":"Medicine and Science In Sports and Exercise","url":"https://www.academia.edu/Documents/in/Medicine_and_Science_In_Sports_and_Exercise"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105228586"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105228586/Skeletal_muscle_vitamin_E_and_ubiquinone_9_responses_to_training_and_lipoate_supplementation"><img alt="Research paper thumbnail of Skeletal muscle vitamin E and ubiquinone 9 responses to training and lipoate supplementation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105228586/Skeletal_muscle_vitamin_E_and_ubiquinone_9_responses_to_training_and_lipoate_supplementation">Skeletal muscle vitamin E and ubiquinone 9 responses to training and lipoate supplementation</a></div><div class="wp-workCard_item"><span>Free Radical Biology and Medicine</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105228586"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105228586"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105228586; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105228586]").text(description); $(".js-view-count[data-work-id=105228586]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105228586; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105228586']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105228586, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105228586]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105228586,"title":"Skeletal muscle vitamin E and ubiquinone 9 responses to training and lipoate supplementation","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Free Radical Biology and Medicine"},"translated_abstract":null,"internal_url":"https://www.academia.edu/105228586/Skeletal_muscle_vitamin_E_and_ubiquinone_9_responses_to_training_and_lipoate_supplementation","translated_internal_url":"","created_at":"2023-08-03T13:22:04.249-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Skeletal_muscle_vitamin_E_and_ubiquinone_9_responses_to_training_and_lipoate_supplementation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":null,"owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[],"research_interests":[{"id":259090,"name":"Oxidative stress and free radical biology and medicine","url":"https://www.academia.edu/Documents/in/Oxidative_stress_and_free_radical_biology_and_medicine"},{"id":357849,"name":"Skeletal Muscle","url":"https://www.academia.edu/Documents/in/Skeletal_Muscle"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4856708"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4856708/Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat"><img alt="Research paper thumbnail of Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat" class="work-thumbnail" src="https://attachments.academia-assets.com/49596184/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4856708/Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat">Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://griffith.academia.edu/LenaVider">Lena Vider</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://atauni.academia.edu/MustafaGul">Mustafa Gul</a></span></div><div class="wp-workCard_item"><span>Pathophysiology</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Oxygen free radicals are highly reactive species that can cause a wide spectrum of cell damage in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Oxygen free radicals are highly reactive species that can cause a wide spectrum of cell damage including lipid peroxidation, enzymes inactivation and DNA damage. Strenuous physical exercise has been shown to impose an oxidative stress on the body due to oxygen free radical generation including an increase in lipid peroxidation. These facts pertain especially to acute or unaccustomed exercise. The purpose of the present study was to examine the effect of the acute swimming exercise on lipid peroxidation. Studies were performed on 20 adult male Swiss albino rats. Animals were divided into 2 groups, 10 rats control group and 9 similar rats exercise group. After exercise blood was taken to measure erythrocyte MDA and haemoglobin levels. Results were expressed as nmol MDAigr Hb. MDA levels from exercise group were not significantly different from control group, with values of 27.4k9.2 and 255.t7.3 nmol MDA/gr Hb respectively (P>O.O5). We concluded that 1 hour swimming exercise doesn't increase lipid peroxidation in erythrocyte.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9f21a5e7284e25b3422de90d760c0d90" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49596184,"asset_id":4856708,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49596184/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4856708"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4856708"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4856708; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4856708]").text(description); $(".js-view-count[data-work-id=4856708]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4856708; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4856708']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 4856708, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9f21a5e7284e25b3422de90d760c0d90" } } $('.js-work-strip[data-work-id=4856708]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4856708,"title":"Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat","translated_title":"","metadata":{"grobid_abstract":"Oxygen free radicals are highly reactive species that can cause a wide spectrum of cell damage including lipid peroxidation, enzymes inactivation and DNA damage. Strenuous physical exercise has been shown to impose an oxidative stress on the body due to oxygen free radical generation including an increase in lipid peroxidation. These facts pertain especially to acute or unaccustomed exercise. The purpose of the present study was to examine the effect of the acute swimming exercise on lipid peroxidation. Studies were performed on 20 adult male Swiss albino rats. Animals were divided into 2 groups, 10 rats control group and 9 similar rats exercise group. After exercise blood was taken to measure erythrocyte MDA and haemoglobin levels. Results were expressed as nmol MDAigr Hb. MDA levels from exercise group were not significantly different from control group, with values of 27.4k9.2 and 255.t7.3 nmol MDA/gr Hb respectively (P\u003eO.O5). We concluded that 1 hour swimming exercise doesn't increase lipid peroxidation in erythrocyte.","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Pathophysiology","grobid_abstract_attachment_id":49596184},"translated_abstract":null,"internal_url":"https://www.academia.edu/4856708/Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat","translated_internal_url":"","created_at":"2013-10-22T12:48:03.285-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":6306844,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":29499727,"work_id":4856708,"tagging_user_id":6306844,"tagged_user_id":null,"co_author_invite_id":390162,"email":"r***3@osu.edu","display_order":0,"name":"Sashwati Roy","title":"Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat"},{"id":29499734,"work_id":4856708,"tagging_user_id":6306844,"tagged_user_id":32891153,"co_author_invite_id":null,"email":"m***l@atauni.edu.tr","affiliation":"Ataturk University","display_order":4194304,"name":"Mustafa Gul","title":"Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat"},{"id":29499738,"work_id":4856708,"tagging_user_id":6306844,"tagged_user_id":null,"co_author_invite_id":690204,"email":"o***n@uef.fi","display_order":6291456,"name":"Osmo Hänninen","title":"Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat"},{"id":29499742,"work_id":4856708,"tagging_user_id":6306844,"tagged_user_id":null,"co_author_invite_id":184989,"email":"c***n@osumc.edu","display_order":7340032,"name":"Chandan Sen","title":"Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat"},{"id":29499746,"work_id":4856708,"tagging_user_id":6306844,"tagged_user_id":null,"co_author_invite_id":390945,"email":"m***y@uef.fi","display_order":7864320,"name":"Mustafa Atalay","title":"Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat"}],"downloadable_attachments":[{"id":49596184,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49596184/thumbnails/1.jpg","file_name":"s0928-4680_2898_2980730-x20161014-6497-168onr7.pdf","download_url":"https://www.academia.edu/attachments/49596184/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Endurance_training_may_decrease_oxidativ.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49596184/s0928-4680_2898_2980730-x20161014-6497-168onr7-libre.pdf?1476456266=\u0026response-content-disposition=attachment%3B+filename%3DEndurance_training_may_decrease_oxidativ.pdf\u0026Expires=1734541248\u0026Signature=Ut21soc429pSkhx9hanwGlDsrOyQ8NXD9j5RUS4rVohFiTkEepMHQwNU0Y~z1lAT2LqkBwW8w6oIvVH8ll-NNG1euVltMT8zLFfusMb0li-J4V96oLuAiHZknxrZImDtFQcOCqCdGQfphEo-uewv2cQvMQw49Pmq-Gs8v0DiJvLhGABY6Ec2X6ybemjYFbvimLFpgshMiHqMsqmdzEW8DlJbrn1qCUVy5ipngJ4V5qQkduku638C6SYSPi1cmqK2Q0Im22k3sT3oAxlOHNTURes4GHb4x3-FR4x6ObGLcpha6baP1WwLmlQU0MX9b7ZUT6eHLSF~8iINiG~oOVRQ9w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat","translated_slug":"","page_count":1,"language":"en","content_type":"Work","summary":"Oxygen free radicals are highly reactive species that can cause a wide spectrum of cell damage including lipid peroxidation, enzymes inactivation and DNA damage. Strenuous physical exercise has been shown to impose an oxidative stress on the body due to oxygen free radical generation including an increase in lipid peroxidation. These facts pertain especially to acute or unaccustomed exercise. The purpose of the present study was to examine the effect of the acute swimming exercise on lipid peroxidation. Studies were performed on 20 adult male Swiss albino rats. Animals were divided into 2 groups, 10 rats control group and 9 similar rats exercise group. After exercise blood was taken to measure erythrocyte MDA and haemoglobin levels. Results were expressed as nmol MDAigr Hb. MDA levels from exercise group were not significantly different from control group, with values of 27.4k9.2 and 255.t7.3 nmol MDA/gr Hb respectively (P\u003eO.O5). We concluded that 1 hour swimming exercise doesn't increase lipid peroxidation in erythrocyte.","owner":{"id":6306844,"first_name":"Lena","middle_initials":"","last_name":"Vider","page_name":"LenaVider","domain_name":"griffith","created_at":"2013-10-22T12:44:35.890-07:00","display_name":"Lena Vider","url":"https://griffith.academia.edu/LenaVider"},"attachments":[{"id":49596184,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49596184/thumbnails/1.jpg","file_name":"s0928-4680_2898_2980730-x20161014-6497-168onr7.pdf","download_url":"https://www.academia.edu/attachments/49596184/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Endurance_training_may_decrease_oxidativ.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49596184/s0928-4680_2898_2980730-x20161014-6497-168onr7-libre.pdf?1476456266=\u0026response-content-disposition=attachment%3B+filename%3DEndurance_training_may_decrease_oxidativ.pdf\u0026Expires=1734541248\u0026Signature=Ut21soc429pSkhx9hanwGlDsrOyQ8NXD9j5RUS4rVohFiTkEepMHQwNU0Y~z1lAT2LqkBwW8w6oIvVH8ll-NNG1euVltMT8zLFfusMb0li-J4V96oLuAiHZknxrZImDtFQcOCqCdGQfphEo-uewv2cQvMQw49Pmq-Gs8v0DiJvLhGABY6Ec2X6ybemjYFbvimLFpgshMiHqMsqmdzEW8DlJbrn1qCUVy5ipngJ4V5qQkduku638C6SYSPi1cmqK2Q0Im22k3sT3oAxlOHNTURes4GHb4x3-FR4x6ObGLcpha6baP1WwLmlQU0MX9b7ZUT6eHLSF~8iINiG~oOVRQ9w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":39001,"name":"Pathophysiology","url":"https://www.academia.edu/Documents/in/Pathophysiology"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":790002,"name":"Streptozotocin","url":"https://www.academia.edu/Documents/in/Streptozotocin"},{"id":846529,"name":"Endurance Training","url":"https://www.academia.edu/Documents/in/Endurance_Training"},{"id":1031967,"name":"Diabetic Rat","url":"https://www.academia.edu/Documents/in/Diabetic_Rat"}],"urls":[{"id":1797321,"url":"http://www.sciencedirect.com/science/article/pii/S092846809880730X"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="102790004"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102790004/Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat"><img alt="Research paper thumbnail of Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat" class="work-thumbnail" src="https://attachments.academia-assets.com/102966503/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102790004/Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat">Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat</a></div><div class="wp-workCard_item"><span>Pathophysiology</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dce1b76799fcb6e9dedff0fdca1b06ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102966503,"asset_id":102790004,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102966503/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102790004"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102790004"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102790004; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=102790004]").text(description); $(".js-view-count[data-work-id=102790004]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 102790004; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='102790004']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 102790004, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dce1b76799fcb6e9dedff0fdca1b06ec" } } $('.js-work-strip[data-work-id=102790004]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":102790004,"title":"Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Pathophysiology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/102790004/Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat","translated_internal_url":"","created_at":"2023-06-03T04:48:38.128-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":102966503,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966503/thumbnails/1.jpg","file_name":"s0928-468028982980730-x20230603-1-ks3l6.pdf","download_url":"https://www.academia.edu/attachments/102966503/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Endurance_training_may_decrease_oxidativ.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966503/s0928-468028982980730-x20230603-1-ks3l6-libre.pdf?1685795371=\u0026response-content-disposition=attachment%3B+filename%3DEndurance_training_may_decrease_oxidativ.pdf\u0026Expires=1734541248\u0026Signature=bayC39ioTiN55AjrsGHEvjFp3hNnwV1uPbDN5nIhitVRU5qnT~j9uoOWTDuHsYAe8NLZINh9GGibGJLIYXxgnqrOGvj1i8bzd~8NTaHTpYnHlmzdl41F2FS5BZ5-h1SvQVse45hUeGBhLm7-u~x5Enk-C5v9MfOlOz5eeZ9qaNiB~rWXxKuqUwsak-d~Fv1x-t-E9MzoOktUkAHHDmWQH6FKcheuSV~BsLCLwoOxCFLzh3wghd917JlPryXp53i4J6asA-eQMgKY4trHiPzoPTdUv4~~iHNlv3mjs8eTGLAeihg6s5kx7Ic-8dXmyvou2HW4iDf2JqvGPR3OMS0EXA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat","translated_slug":"","page_count":1,"language":"en","content_type":"Work","summary":null,"owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":102966503,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966503/thumbnails/1.jpg","file_name":"s0928-468028982980730-x20230603-1-ks3l6.pdf","download_url":"https://www.academia.edu/attachments/102966503/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Endurance_training_may_decrease_oxidativ.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966503/s0928-468028982980730-x20230603-1-ks3l6-libre.pdf?1685795371=\u0026response-content-disposition=attachment%3B+filename%3DEndurance_training_may_decrease_oxidativ.pdf\u0026Expires=1734541248\u0026Signature=bayC39ioTiN55AjrsGHEvjFp3hNnwV1uPbDN5nIhitVRU5qnT~j9uoOWTDuHsYAe8NLZINh9GGibGJLIYXxgnqrOGvj1i8bzd~8NTaHTpYnHlmzdl41F2FS5BZ5-h1SvQVse45hUeGBhLm7-u~x5Enk-C5v9MfOlOz5eeZ9qaNiB~rWXxKuqUwsak-d~Fv1x-t-E9MzoOktUkAHHDmWQH6FKcheuSV~BsLCLwoOxCFLzh3wghd917JlPryXp53i4J6asA-eQMgKY4trHiPzoPTdUv4~~iHNlv3mjs8eTGLAeihg6s5kx7Ic-8dXmyvou2HW4iDf2JqvGPR3OMS0EXA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":39001,"name":"Pathophysiology","url":"https://www.academia.edu/Documents/in/Pathophysiology"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":790002,"name":"Streptozotocin","url":"https://www.academia.edu/Documents/in/Streptozotocin"},{"id":846529,"name":"Endurance Training","url":"https://www.academia.edu/Documents/in/Endurance_Training"},{"id":1031967,"name":"Diabetic Rat","url":"https://www.academia.edu/Documents/in/Diabetic_Rat"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="102790003"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102790003/Toxicity_of_some_bis_mannich_bases_and_corresponding_piperidinols_in_the_brine_shrimp_Artemia_salina_Bioassay"><img alt="Research paper thumbnail of Toxicity of some bis mannich bases and corresponding piperidinols in the brine shrimp (Artemia salina) Bioassay" class="work-thumbnail" src="https://attachments.academia-assets.com/102966703/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102790003/Toxicity_of_some_bis_mannich_bases_and_corresponding_piperidinols_in_the_brine_shrimp_Artemia_salina_Bioassay">Toxicity of some bis mannich bases and corresponding piperidinols in the brine shrimp (Artemia salina) Bioassay</a></div><div class="wp-workCard_item"><span>Journal of Applied Toxicology</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Some acetophenone-derived bis Mannich bases were synthesized: bis[beta-benzoylethyl]ethylamine hy...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Some acetophenone-derived bis Mannich bases were synthesized: bis[beta-benzoylethyl]ethylamine hydrochloride (IIa), bis[beta-(p-methylbenzoyl)ethyl]ethylamine hydrochloride (IIb), bis[beta-(p-chlorobenzoyl)ethyl]ethy- lamine hydrochloride (IId), bis[(2-thienylcarbonyl)ethyl]ethylamine hydrochloride (IIe); some corresponding piperidinol derivatives: 3-benzoyl-1-ethyl-4-phenyl-4-piperidinol hydrochloride (IIIa), 1-ethyl-3-(p-methyl- benzoyl)-4-(p-methylphenyl)-4-piperidinol hydrochloride (IIIb), 1-ethyl-3-(p-methoxybenzoyl)-4-(p-methoxy- phenyl)-4-piperidinol hydrochloride (IIIc), 1-ethyl-3-(p-chlorobenzoyl)-4-(p-chlorophenyl)-4-piperidinol hydrochloride (IIId), 1-ethyl-4-(2-thienyl)-3-(2-thienylcarbonyl)-4-piperidinol hydrochloride (IIIe); and some representative quaternary piperidinols: 3-benzoyl-1-ethyl-4-hydroxy-1-methyl-4-phenylpiperidinium iodide (IIIf), 1-ethyl-4-hydroxy-1-methyl-3-(p-methylbenzoyl)-4-(p-methylphenyl)piperidinium iodide (IIIg). Toxicity was tested by the brine shrimp bioassay as an intermediate test before further in vivo animal experiments. Piperidine derivatives were found to be more potent than bis Mannich bases. Quaternary piperidine derivatives IIIf and IIIg and also non-quaternary piperidine derivatives IIIb, IIIe, IIIc and IIId were more toxic than 5-fluorouracil in brine shrimp bioassay. Except for IIe, bis Mannich bases were not effective. Quaternization and conversion of bis Mannich bases to corresponding piperidines improved the toxicity. The lipid solubility of the compounds may not affect the toxicity. From these findings the quaternary piperidine derivatives IIIf and IIIg could be used in further drug development and also for in vivo experiments.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1269974ee7276ebc1c32e186aceb22ed" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102966703,"asset_id":102790003,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102966703/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102790003"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102790003"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102790003; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=102790003]").text(description); $(".js-view-count[data-work-id=102790003]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 102790003; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='102790003']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 102790003, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1269974ee7276ebc1c32e186aceb22ed" } } $('.js-work-strip[data-work-id=102790003]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":102790003,"title":"Toxicity of some bis mannich bases and corresponding piperidinols in the brine shrimp (Artemia salina) Bioassay","translated_title":"","metadata":{"abstract":"Some acetophenone-derived bis Mannich bases were synthesized: bis[beta-benzoylethyl]ethylamine hydrochloride (IIa), bis[beta-(p-methylbenzoyl)ethyl]ethylamine hydrochloride (IIb), bis[beta-(p-chlorobenzoyl)ethyl]ethy- lamine hydrochloride (IId), bis[(2-thienylcarbonyl)ethyl]ethylamine hydrochloride (IIe); some corresponding piperidinol derivatives: 3-benzoyl-1-ethyl-4-phenyl-4-piperidinol hydrochloride (IIIa), 1-ethyl-3-(p-methyl- benzoyl)-4-(p-methylphenyl)-4-piperidinol hydrochloride (IIIb), 1-ethyl-3-(p-methoxybenzoyl)-4-(p-methoxy- phenyl)-4-piperidinol hydrochloride (IIIc), 1-ethyl-3-(p-chlorobenzoyl)-4-(p-chlorophenyl)-4-piperidinol hydrochloride (IIId), 1-ethyl-4-(2-thienyl)-3-(2-thienylcarbonyl)-4-piperidinol hydrochloride (IIIe); and some representative quaternary piperidinols: 3-benzoyl-1-ethyl-4-hydroxy-1-methyl-4-phenylpiperidinium iodide (IIIf), 1-ethyl-4-hydroxy-1-methyl-3-(p-methylbenzoyl)-4-(p-methylphenyl)piperidinium iodide (IIIg). Toxicity was tested by the brine shrimp bioassay as an intermediate test before further in vivo animal experiments. Piperidine derivatives were found to be more potent than bis Mannich bases. Quaternary piperidine derivatives IIIf and IIIg and also non-quaternary piperidine derivatives IIIb, IIIe, IIIc and IIId were more toxic than 5-fluorouracil in brine shrimp bioassay. Except for IIe, bis Mannich bases were not effective. Quaternization and conversion of bis Mannich bases to corresponding piperidines improved the toxicity. The lipid solubility of the compounds may not affect the toxicity. From these findings the quaternary piperidine derivatives IIIf and IIIg could be used in further drug development and also for in vivo experiments.","publisher":"Wiley-Blackwell","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Journal of Applied Toxicology"},"translated_abstract":"Some acetophenone-derived bis Mannich bases were synthesized: bis[beta-benzoylethyl]ethylamine hydrochloride (IIa), bis[beta-(p-methylbenzoyl)ethyl]ethylamine hydrochloride (IIb), bis[beta-(p-chlorobenzoyl)ethyl]ethy- lamine hydrochloride (IId), bis[(2-thienylcarbonyl)ethyl]ethylamine hydrochloride (IIe); some corresponding piperidinol derivatives: 3-benzoyl-1-ethyl-4-phenyl-4-piperidinol hydrochloride (IIIa), 1-ethyl-3-(p-methyl- benzoyl)-4-(p-methylphenyl)-4-piperidinol hydrochloride (IIIb), 1-ethyl-3-(p-methoxybenzoyl)-4-(p-methoxy- phenyl)-4-piperidinol hydrochloride (IIIc), 1-ethyl-3-(p-chlorobenzoyl)-4-(p-chlorophenyl)-4-piperidinol hydrochloride (IIId), 1-ethyl-4-(2-thienyl)-3-(2-thienylcarbonyl)-4-piperidinol hydrochloride (IIIe); and some representative quaternary piperidinols: 3-benzoyl-1-ethyl-4-hydroxy-1-methyl-4-phenylpiperidinium iodide (IIIf), 1-ethyl-4-hydroxy-1-methyl-3-(p-methylbenzoyl)-4-(p-methylphenyl)piperidinium iodide (IIIg). Toxicity was tested by the brine shrimp bioassay as an intermediate test before further in vivo animal experiments. Piperidine derivatives were found to be more potent than bis Mannich bases. Quaternary piperidine derivatives IIIf and IIIg and also non-quaternary piperidine derivatives IIIb, IIIe, IIIc and IIId were more toxic than 5-fluorouracil in brine shrimp bioassay. Except for IIe, bis Mannich bases were not effective. Quaternization and conversion of bis Mannich bases to corresponding piperidines improved the toxicity. The lipid solubility of the compounds may not affect the toxicity. From these findings the quaternary piperidine derivatives IIIf and IIIg could be used in further drug development and also for in vivo experiments.","internal_url":"https://www.academia.edu/102790003/Toxicity_of_some_bis_mannich_bases_and_corresponding_piperidinols_in_the_brine_shrimp_Artemia_salina_Bioassay","translated_internal_url":"","created_at":"2023-06-03T04:48:37.957-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":102966703,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966703/thumbnails/1.jpg","file_name":"Gul_HI_et_al._JAT_2003.pdf","download_url":"https://www.academia.edu/attachments/102966703/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Toxicity_of_some_bis_mannich_bases_and_c.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966703/Gul_HI_et_al._JAT_2003-libre.pdf?1685795324=\u0026response-content-disposition=attachment%3B+filename%3DToxicity_of_some_bis_mannich_bases_and_c.pdf\u0026Expires=1734541248\u0026Signature=hSO-~GoMJN-RR-mQPpENsugBR-Bo91qtBgc8D1tYqKxvF0QExZGKPWSxcfuq0ld-1BltcU2CISlAcVp40N4PFXzME~QoXkNscX6KsN73hooEvyNkHB~SsY9mD~UJjAPsSI~XEVC9xgVO9RlmUypVtRsdw3M4zoMbwIHA~SyCHUzLv1iFNRmHuQIRdk9jJQVCuGfkDpc2L7154kma8ztOn8Pzq44hhJo8ysjwkieSjPuC49~n6xwLRAGVObcUb1iZfI6~T4NhAoh3hAqFyWb2SMN~CleUWW3yMT8Lz82Sx1BPl75lX3vhOR2luDkrfEq8bcidCl-Cbg56nmg-04vMnw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Toxicity_of_some_bis_mannich_bases_and_corresponding_piperidinols_in_the_brine_shrimp_Artemia_salina_Bioassay","translated_slug":"","page_count":5,"language":"en","content_type":"Work","summary":"Some acetophenone-derived bis Mannich bases were synthesized: bis[beta-benzoylethyl]ethylamine hydrochloride (IIa), bis[beta-(p-methylbenzoyl)ethyl]ethylamine hydrochloride (IIb), bis[beta-(p-chlorobenzoyl)ethyl]ethy- lamine hydrochloride (IId), bis[(2-thienylcarbonyl)ethyl]ethylamine hydrochloride (IIe); some corresponding piperidinol derivatives: 3-benzoyl-1-ethyl-4-phenyl-4-piperidinol hydrochloride (IIIa), 1-ethyl-3-(p-methyl- benzoyl)-4-(p-methylphenyl)-4-piperidinol hydrochloride (IIIb), 1-ethyl-3-(p-methoxybenzoyl)-4-(p-methoxy- phenyl)-4-piperidinol hydrochloride (IIIc), 1-ethyl-3-(p-chlorobenzoyl)-4-(p-chlorophenyl)-4-piperidinol hydrochloride (IIId), 1-ethyl-4-(2-thienyl)-3-(2-thienylcarbonyl)-4-piperidinol hydrochloride (IIIe); and some representative quaternary piperidinols: 3-benzoyl-1-ethyl-4-hydroxy-1-methyl-4-phenylpiperidinium iodide (IIIf), 1-ethyl-4-hydroxy-1-methyl-3-(p-methylbenzoyl)-4-(p-methylphenyl)piperidinium iodide (IIIg). Toxicity was tested by the brine shrimp bioassay as an intermediate test before further in vivo animal experiments. Piperidine derivatives were found to be more potent than bis Mannich bases. Quaternary piperidine derivatives IIIf and IIIg and also non-quaternary piperidine derivatives IIIb, IIIe, IIIc and IIId were more toxic than 5-fluorouracil in brine shrimp bioassay. Except for IIe, bis Mannich bases were not effective. Quaternization and conversion of bis Mannich bases to corresponding piperidines improved the toxicity. The lipid solubility of the compounds may not affect the toxicity. From these findings the quaternary piperidine derivatives IIIf and IIIg could be used in further drug development and also for in vivo experiments.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":102966703,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966703/thumbnails/1.jpg","file_name":"Gul_HI_et_al._JAT_2003.pdf","download_url":"https://www.academia.edu/attachments/102966703/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Toxicity_of_some_bis_mannich_bases_and_c.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966703/Gul_HI_et_al._JAT_2003-libre.pdf?1685795324=\u0026response-content-disposition=attachment%3B+filename%3DToxicity_of_some_bis_mannich_bases_and_c.pdf\u0026Expires=1734541248\u0026Signature=hSO-~GoMJN-RR-mQPpENsugBR-Bo91qtBgc8D1tYqKxvF0QExZGKPWSxcfuq0ld-1BltcU2CISlAcVp40N4PFXzME~QoXkNscX6KsN73hooEvyNkHB~SsY9mD~UJjAPsSI~XEVC9xgVO9RlmUypVtRsdw3M4zoMbwIHA~SyCHUzLv1iFNRmHuQIRdk9jJQVCuGfkDpc2L7154kma8ztOn8Pzq44hhJo8ysjwkieSjPuC49~n6xwLRAGVObcUb1iZfI6~T4NhAoh3hAqFyWb2SMN~CleUWW3yMT8Lz82Sx1BPl75lX3vhOR2luDkrfEq8bcidCl-Cbg56nmg-04vMnw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":2215,"name":"Water","url":"https://www.academia.edu/Documents/in/Water"},{"id":8058,"name":"Artemia","url":"https://www.academia.edu/Documents/in/Artemia"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":61214,"name":"Longevity","url":"https://www.academia.edu/Documents/in/Longevity"},{"id":67405,"name":"Toxicity","url":"https://www.academia.edu/Documents/in/Toxicity"},{"id":205581,"name":"Partition Coefficient","url":"https://www.academia.edu/Documents/in/Partition_Coefficient"},{"id":205584,"name":"Solubility","url":"https://www.academia.edu/Documents/in/Solubility"},{"id":382529,"name":"Artemia salina","url":"https://www.academia.edu/Documents/in/Artemia_salina"},{"id":695018,"name":"Molecular weight","url":"https://www.academia.edu/Documents/in/Molecular_weight"},{"id":951749,"name":"Ambroxol Hydrochloride","url":"https://www.academia.edu/Documents/in/Ambroxol_Hydrochloride"},{"id":980394,"name":"Acute Toxicity","url":"https://www.academia.edu/Documents/in/Acute_Toxicity"},{"id":1109769,"name":"Biological Assay","url":"https://www.academia.edu/Documents/in/Biological_Assay"},{"id":1377823,"name":"Applied Toxicology","url":"https://www.academia.edu/Documents/in/Applied_Toxicology"},{"id":1880638,"name":"Piperidines","url":"https://www.academia.edu/Documents/in/Piperidines"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="102790002"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102790002/Syntheses_and_Stability_Studies_of_Some_Mannich_Bases_of_Acetophenones_and_Evaluation_of_their_Cytotoxicity_against_Jurkat_Cells"><img alt="Research paper thumbnail of Syntheses and Stability Studies of Some Mannich Bases of Acetophenones and Evaluation of their Cytotoxicity against Jurkat Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/102966498/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102790002/Syntheses_and_Stability_Studies_of_Some_Mannich_Bases_of_Acetophenones_and_Evaluation_of_their_Cytotoxicity_against_Jurkat_Cells">Syntheses and Stability Studies of Some Mannich Bases of Acetophenones and Evaluation of their Cytotoxicity against Jurkat Cells</a></div><div class="wp-workCard_item"><span>Arzneimittelforschung</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="21eb5fcd49c2b9f93e6e29fc50f2ac5a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102966498,"asset_id":102790002,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102966498/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102790002"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102790002"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102790002; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=102790002]").text(description); $(".js-view-count[data-work-id=102790002]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 102790002; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='102790002']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 102790002, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "21eb5fcd49c2b9f93e6e29fc50f2ac5a" } } $('.js-work-strip[data-work-id=102790002]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":102790002,"title":"Syntheses and Stability Studies of Some Mannich Bases of Acetophenones and Evaluation of their Cytotoxicity against Jurkat Cells","translated_title":"","metadata":{"publisher":"Georg Thieme Verlag KG","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Arzneimittelforschung"},"translated_abstract":null,"internal_url":"https://www.academia.edu/102790002/Syntheses_and_Stability_Studies_of_Some_Mannich_Bases_of_Acetophenones_and_Evaluation_of_their_Cytotoxicity_against_Jurkat_Cells","translated_internal_url":"","created_at":"2023-06-03T04:48:37.705-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":102966498,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966498/thumbnails/1.jpg","file_name":"chin.20024611220230603-1-i49wvi.pdf","download_url":"https://www.academia.edu/attachments/102966498/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Syntheses_and_Stability_Studies_of_Some.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966498/chin.20024611220230603-1-i49wvi-libre.pdf?1685795370=\u0026response-content-disposition=attachment%3B+filename%3DSyntheses_and_Stability_Studies_of_Some.pdf\u0026Expires=1734541248\u0026Signature=Mnl8yRdhXPbrC1hs23-fVal~puQk0xsBEZECdUUsrfsq2nCY9OncEy8~NC3CcSL4JleceOchP5-UUQpZARpl7LL7~p6CB8TRu4lEzE-j-Wj03ioQGOR9pKwx1y7nom21ptGhU2evhWOcGG-XNEP1l9zRPEjxmn55gPNiaKtWIX~-6iLeQCZ5hpzfGNcVfRgcFR9VtIxgwvnmc6FJYCwREG94CC6ZgVIEUSwqGDDzTvHKOBMU1qvQraRl8JPSP5fAB7TGaGBxH5tDlghxxpp6~OS5yVsnZX-BjCE6cBkFtQFtDJnD~m-Gj0Wl2SVIAllMavFjlqtqdvLC1oUUySbNXg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Syntheses_and_Stability_Studies_of_Some_Mannich_Bases_of_Acetophenones_and_Evaluation_of_their_Cytotoxicity_against_Jurkat_Cells","translated_slug":"","page_count":1,"language":"en","content_type":"Work","summary":null,"owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":102966498,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966498/thumbnails/1.jpg","file_name":"chin.20024611220230603-1-i49wvi.pdf","download_url":"https://www.academia.edu/attachments/102966498/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Syntheses_and_Stability_Studies_of_Some.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966498/chin.20024611220230603-1-i49wvi-libre.pdf?1685795370=\u0026response-content-disposition=attachment%3B+filename%3DSyntheses_and_Stability_Studies_of_Some.pdf\u0026Expires=1734541248\u0026Signature=Mnl8yRdhXPbrC1hs23-fVal~puQk0xsBEZECdUUsrfsq2nCY9OncEy8~NC3CcSL4JleceOchP5-UUQpZARpl7LL7~p6CB8TRu4lEzE-j-Wj03ioQGOR9pKwx1y7nom21ptGhU2evhWOcGG-XNEP1l9zRPEjxmn55gPNiaKtWIX~-6iLeQCZ5hpzfGNcVfRgcFR9VtIxgwvnmc6FJYCwREG94CC6ZgVIEUSwqGDDzTvHKOBMU1qvQraRl8JPSP5fAB7TGaGBxH5tDlghxxpp6~OS5yVsnZX-BjCE6cBkFtQFtDJnD~m-Gj0Wl2SVIAllMavFjlqtqdvLC1oUUySbNXg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":22050,"name":"Cytotoxicity","url":"https://www.academia.edu/Documents/in/Cytotoxicity"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":42135,"name":"Drug","url":"https://www.academia.edu/Documents/in/Drug"},{"id":59370,"name":"In Vitro","url":"https://www.academia.edu/Documents/in/In_Vitro"},{"id":114715,"name":"Stereochemistry","url":"https://www.academia.edu/Documents/in/Stereochemistry"},{"id":172024,"name":"Analog","url":"https://www.academia.edu/Documents/in/Analog"},{"id":582465,"name":"Cyclization","url":"https://www.academia.edu/Documents/in/Cyclization"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship"},{"id":1135814,"name":"Drug Stability","url":"https://www.academia.edu/Documents/in/Drug_Stability"},{"id":1152821,"name":"Chemical Synthesis","url":"https://www.academia.edu/Documents/in/Chemical_Synthesis"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents"},{"id":2814759,"name":"Ethylamine","url":"https://www.academia.edu/Documents/in/Ethylamine"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":31972031,"url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0031-1299942.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="102789946"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102789946/Sorafenib_Alleviates_Inflammatory_Signaling_of_Tumor_Microenvironment_in_Precancerous_Lung_Injuries"><img alt="Research paper thumbnail of Sorafenib Alleviates Inflammatory Signaling of Tumor Microenvironment in Precancerous Lung Injuries" class="work-thumbnail" src="https://attachments.academia-assets.com/102966450/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102789946/Sorafenib_Alleviates_Inflammatory_Signaling_of_Tumor_Microenvironment_in_Precancerous_Lung_Injuries">Sorafenib Alleviates Inflammatory Signaling of Tumor Microenvironment in Precancerous Lung Injuries</a></div><div class="wp-workCard_item"><span>Pharmaceuticals</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">According to population-based studies, lung cancer is the prominent reason for cancer-related mor...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">According to population-based studies, lung cancer is the prominent reason for cancer-related mortality worldwide in males and is also rising in females at an alarming rate. Sorafenib (SOR), which is approved for the treatment of hepatocellular carcinoma and renal cell carcinoma, is a multitargeted protein kinase inhibitor. Additionally, SOR is the subject of interest for preclinical and clinical trials in lung cancer. This study was designed to assess in vivo the possible effects of sorafenib (SOR) in diethylnitrosamine (DEN)-induced lung carcinogenesis and examine its probable mechanisms of action. A total of 30 adult male rats were divided into three groups (1) control, (2) DEN, and (3) DEN + SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum and lung tissue samples were analyzed to d...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b83f9b2e93b6795b38a5fe0239a994c4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102966450,"asset_id":102789946,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102966450/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102789946"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102789946"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102789946; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=102789946]").text(description); $(".js-view-count[data-work-id=102789946]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 102789946; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='102789946']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 102789946, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b83f9b2e93b6795b38a5fe0239a994c4" } } $('.js-work-strip[data-work-id=102789946]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":102789946,"title":"Sorafenib Alleviates Inflammatory Signaling of Tumor Microenvironment in Precancerous Lung Injuries","translated_title":"","metadata":{"abstract":"According to population-based studies, lung cancer is the prominent reason for cancer-related mortality worldwide in males and is also rising in females at an alarming rate. Sorafenib (SOR), which is approved for the treatment of hepatocellular carcinoma and renal cell carcinoma, is a multitargeted protein kinase inhibitor. Additionally, SOR is the subject of interest for preclinical and clinical trials in lung cancer. This study was designed to assess in vivo the possible effects of sorafenib (SOR) in diethylnitrosamine (DEN)-induced lung carcinogenesis and examine its probable mechanisms of action. A total of 30 adult male rats were divided into three groups (1) control, (2) DEN, and (3) DEN + SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum and lung tissue samples were analyzed to d...","publisher":"MDPI AG","publication_name":"Pharmaceuticals"},"translated_abstract":"According to population-based studies, lung cancer is the prominent reason for cancer-related mortality worldwide in males and is also rising in females at an alarming rate. Sorafenib (SOR), which is approved for the treatment of hepatocellular carcinoma and renal cell carcinoma, is a multitargeted protein kinase inhibitor. Additionally, SOR is the subject of interest for preclinical and clinical trials in lung cancer. This study was designed to assess in vivo the possible effects of sorafenib (SOR) in diethylnitrosamine (DEN)-induced lung carcinogenesis and examine its probable mechanisms of action. A total of 30 adult male rats were divided into three groups (1) control, (2) DEN, and (3) DEN + SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum and lung tissue samples were analyzed to d...","internal_url":"https://www.academia.edu/102789946/Sorafenib_Alleviates_Inflammatory_Signaling_of_Tumor_Microenvironment_in_Precancerous_Lung_Injuries","translated_internal_url":"","created_at":"2023-06-03T04:47:11.056-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":102966450,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966450/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/102966450/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Sorafenib_Alleviates_Inflammatory_Signal.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966450/pdf-libre.pdf?1685795396=\u0026response-content-disposition=attachment%3B+filename%3DSorafenib_Alleviates_Inflammatory_Signal.pdf\u0026Expires=1734541248\u0026Signature=A6A3gEudXNBTMu~wDzOVKRKbxsU5znM1cb~-FRhu4Qqi-nHFe4SbvU-b6UHyyRAaJQ~JUS9zGPoTjYmnxMg4NKAxoGVy-dbPF760wXDA1rVGhLbIKruCOkB6Idri30gn7RXprK049jrZWI-E2OJXbmhorXIt5IQiFd6z~LGCJQgboPLBMZ0i4X3vfdXIh7TR3HSPxiCZZngnjc6zQPOZrSIWsJzppaujf39mT8RFw6I~ogccAwxFN7q8K3ep3BcloSMGyBDAbl4jfAHeAuFcz88U~SRMcII8n3UQLjdx7JGOYaJLxLV9TUarMPQfA8nn3u6g4bEup8ulKZqt~Um-1A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Sorafenib_Alleviates_Inflammatory_Signaling_of_Tumor_Microenvironment_in_Precancerous_Lung_Injuries","translated_slug":"","page_count":14,"language":"en","content_type":"Work","summary":"According to population-based studies, lung cancer is the prominent reason for cancer-related mortality worldwide in males and is also rising in females at an alarming rate. Sorafenib (SOR), which is approved for the treatment of hepatocellular carcinoma and renal cell carcinoma, is a multitargeted protein kinase inhibitor. Additionally, SOR is the subject of interest for preclinical and clinical trials in lung cancer. This study was designed to assess in vivo the possible effects of sorafenib (SOR) in diethylnitrosamine (DEN)-induced lung carcinogenesis and examine its probable mechanisms of action. A total of 30 adult male rats were divided into three groups (1) control, (2) DEN, and (3) DEN + SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum and lung tissue samples were analyzed to d...","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":102966450,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966450/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/102966450/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Sorafenib_Alleviates_Inflammatory_Signal.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966450/pdf-libre.pdf?1685795396=\u0026response-content-disposition=attachment%3B+filename%3DSorafenib_Alleviates_Inflammatory_Signal.pdf\u0026Expires=1734541248\u0026Signature=A6A3gEudXNBTMu~wDzOVKRKbxsU5znM1cb~-FRhu4Qqi-nHFe4SbvU-b6UHyyRAaJQ~JUS9zGPoTjYmnxMg4NKAxoGVy-dbPF760wXDA1rVGhLbIKruCOkB6Idri30gn7RXprK049jrZWI-E2OJXbmhorXIt5IQiFd6z~LGCJQgboPLBMZ0i4X3vfdXIh7TR3HSPxiCZZngnjc6zQPOZrSIWsJzppaujf39mT8RFw6I~ogccAwxFN7q8K3ep3BcloSMGyBDAbl4jfAHeAuFcz88U~SRMcII8n3UQLjdx7JGOYaJLxLV9TUarMPQfA8nn3u6g4bEup8ulKZqt~Um-1A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51698,"name":"Lung Cancer","url":"https://www.academia.edu/Documents/in/Lung_Cancer"},{"id":54650,"name":"Pharmaceuticals","url":"https://www.academia.edu/Documents/in/Pharmaceuticals"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung"},{"id":340262,"name":"Carcinogenesis","url":"https://www.academia.edu/Documents/in/Carcinogenesis"},{"id":1003057,"name":"Sorafenib","url":"https://www.academia.edu/Documents/in/Sorafenib"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":31971998,"url":"https://www.mdpi.com/1424-8247/16/2/221/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95720747"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95720747/Ulusal_Spor_Bilimleri_Dergisi"><img alt="Research paper thumbnail of Ulusal Spor Bilimleri Dergisi" class="work-thumbnail" src="https://attachments.academia-assets.com/97824795/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95720747/Ulusal_Spor_Bilimleri_Dergisi">Ulusal Spor Bilimleri Dergisi</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Yüksek yoğunluklu egzersiz sırasında (örneğin, laktat eşiğinin üzerinde çalışmak) kasılan iskelet...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Yüksek yoğunluklu egzersiz sırasında (örneğin, laktat eşiğinin üzerinde çalışmak) kasılan iskelet kasları, önemli miktarda hidrojen (H +) iyonu birikimine sebep olur. Bu H + iyonları, egzersize bağlı metabolik asidozun gelişmesine ve asit-baz homeostazının bozulmasına sebep olabilir. Dolayısıyla bu çalışmanın amacı (a) egzersize bağlı vücut pH seviyesinde meydana gelen değişimlerin fizyolojik mekanizmasını ve sportif performansa etkisini, (b) egzersize bağlı asit-baz homeostazında görülen değişimlerin fizyolojik mekanizmasını ve sportif performansa etkisini ve (c) bahsedilen fizyolojik olayların olumsuz etkilerinin minimize edilmesi için kullanılabilecek besin takviyelerini güncel literatür ışığında incelemeyi amaçlamıştır. Bu derleme çalışmasında egzersiz ve asit-baz dengesi, egzersize bağlı asit-baz bozuklukları ile ilgili konuları içeren bilimsel metinler ve kitaplar incelenmiştir. Pub Med, Web of Science, Medline, Cochrane Library, Google Scholar ve ULAKBİM elektronik veri tabanları "exercise and pH balance", "acidosis and exercise", "exercise and acid-base balance", "athletic performance and fluid balance", "sport supplements for asid-base balance", "sports beverage for athletes'' ve "nutritional strategies for acid-base balance" anahtar kelimeleri kullanılarak taranmıştır. Metabolik asidozla birlikte sporcularda yorgunluk hissi, kaslardaki mekanik performansın azalması gibi etmenler dolayısıyla egzersiz performansını da olumsuz etkiler. Bu nedenle sporcular tarafından yüksek şiddetli egzersizlerde bozulabilecek asit-baz homeostazı için destekleyici besinsel takviyelerin kullanılması (sodyum bikarbonat, sodyum sitrat, beta alanin vb.) sportif performansın optimal biçimde sürdürülebilmesi, oluşabilecek yorgunluğun geciktirilebilmesi ve performansın artırılması için tavsiye edilen alternatiflerdir.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e44dbf90db6bb87dbedfc2d1ccc6049e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97824795,"asset_id":95720747,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97824795/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95720747"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95720747"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95720747; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95720747]").text(description); $(".js-view-count[data-work-id=95720747]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95720747; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95720747']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95720747, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e44dbf90db6bb87dbedfc2d1ccc6049e" } } $('.js-work-strip[data-work-id=95720747]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95720747,"title":"Ulusal Spor Bilimleri Dergisi","translated_title":"","metadata":{"grobid_abstract":"Yüksek yoğunluklu egzersiz sırasında (örneğin, laktat eşiğinin üzerinde çalışmak) kasılan iskelet kasları, önemli miktarda hidrojen (H +) iyonu birikimine sebep olur. Bu H + iyonları, egzersize bağlı metabolik asidozun gelişmesine ve asit-baz homeostazının bozulmasına sebep olabilir. Dolayısıyla bu çalışmanın amacı (a) egzersize bağlı vücut pH seviyesinde meydana gelen değişimlerin fizyolojik mekanizmasını ve sportif performansa etkisini, (b) egzersize bağlı asit-baz homeostazında görülen değişimlerin fizyolojik mekanizmasını ve sportif performansa etkisini ve (c) bahsedilen fizyolojik olayların olumsuz etkilerinin minimize edilmesi için kullanılabilecek besin takviyelerini güncel literatür ışığında incelemeyi amaçlamıştır. Bu derleme çalışmasında egzersiz ve asit-baz dengesi, egzersize bağlı asit-baz bozuklukları ile ilgili konuları içeren bilimsel metinler ve kitaplar incelenmiştir. Pub Med, Web of Science, Medline, Cochrane Library, Google Scholar ve ULAKBİM elektronik veri tabanları \"exercise and pH balance\", \"acidosis and exercise\", \"exercise and acid-base balance\", \"athletic performance and fluid balance\", \"sport supplements for asid-base balance\", \"sports beverage for athletes'' ve \"nutritional strategies for acid-base balance\" anahtar kelimeleri kullanılarak taranmıştır. Metabolik asidozla birlikte sporcularda yorgunluk hissi, kaslardaki mekanik performansın azalması gibi etmenler dolayısıyla egzersiz performansını da olumsuz etkiler. Bu nedenle sporcular tarafından yüksek şiddetli egzersizlerde bozulabilecek asit-baz homeostazı için destekleyici besinsel takviyelerin kullanılması (sodyum bikarbonat, sodyum sitrat, beta alanin vb.) sportif performansın optimal biçimde sürdürülebilmesi, oluşabilecek yorgunluğun geciktirilebilmesi ve performansın artırılması için tavsiye edilen alternatiflerdir.","grobid_abstract_attachment_id":97824795},"translated_abstract":null,"internal_url":"https://www.academia.edu/95720747/Ulusal_Spor_Bilimleri_Dergisi","translated_internal_url":"","created_at":"2023-01-26T02:19:41.429-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97824795,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97824795/thumbnails/1.jpg","file_name":"Gencoglu_C._et_al._Egzersizde_Asit_Baz_Homeostazi_Bir_Geleneksel_Derleme_Ulusal_Spor_Bilimleri_Dergisi_2022.pdf","download_url":"https://www.academia.edu/attachments/97824795/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Ulusal_Spor_Bilimleri_Dergisi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97824795/Gencoglu_C._et_al._Egzersizde_Asit_Baz_Homeostazi_Bir_Geleneksel_Derleme_Ulusal_Spor_Bilimleri_Dergisi_2022-libre.pdf?1674731356=\u0026response-content-disposition=attachment%3B+filename%3DUlusal_Spor_Bilimleri_Dergisi.pdf\u0026Expires=1734541248\u0026Signature=G22S-3mNS7ZxM~UI845hx~CjLw93BV-RMNRY3wTedIVKjmqgBEhSU2N7hxvNpxjJHrrM8J~TpjZxcAmg9xSfGKkGaa8nL35q4pSjI2V43RDacg2aFknhfx9IoBrJkIhv21b5QeWmj8Kuu5d9l3flqplaYKdJWQbToKrQDVy~bnGMX-ELqtdj3Sab4~rF7NF1mBp2qecduslgDtyy2eo2k4fS-OdMy2h9ohxSy7ACqLeKrrpwEvrcJEX-A6hGfbh5iLTZoL6LyeXOqt2O6dXCEO1bp8wrBYVp6pT5rliWUVEwVIHEa6giL~V~tYbvVnLYN4uRUxNjO08ez2BpBKRy3Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Ulusal_Spor_Bilimleri_Dergisi","translated_slug":"","page_count":21,"language":"tr","content_type":"Work","summary":"Yüksek yoğunluklu egzersiz sırasında (örneğin, laktat eşiğinin üzerinde çalışmak) kasılan iskelet kasları, önemli miktarda hidrojen (H +) iyonu birikimine sebep olur. Bu H + iyonları, egzersize bağlı metabolik asidozun gelişmesine ve asit-baz homeostazının bozulmasına sebep olabilir. Dolayısıyla bu çalışmanın amacı (a) egzersize bağlı vücut pH seviyesinde meydana gelen değişimlerin fizyolojik mekanizmasını ve sportif performansa etkisini, (b) egzersize bağlı asit-baz homeostazında görülen değişimlerin fizyolojik mekanizmasını ve sportif performansa etkisini ve (c) bahsedilen fizyolojik olayların olumsuz etkilerinin minimize edilmesi için kullanılabilecek besin takviyelerini güncel literatür ışığında incelemeyi amaçlamıştır. Bu derleme çalışmasında egzersiz ve asit-baz dengesi, egzersize bağlı asit-baz bozuklukları ile ilgili konuları içeren bilimsel metinler ve kitaplar incelenmiştir. Pub Med, Web of Science, Medline, Cochrane Library, Google Scholar ve ULAKBİM elektronik veri tabanları \"exercise and pH balance\", \"acidosis and exercise\", \"exercise and acid-base balance\", \"athletic performance and fluid balance\", \"sport supplements for asid-base balance\", \"sports beverage for athletes'' ve \"nutritional strategies for acid-base balance\" anahtar kelimeleri kullanılarak taranmıştır. Metabolik asidozla birlikte sporcularda yorgunluk hissi, kaslardaki mekanik performansın azalması gibi etmenler dolayısıyla egzersiz performansını da olumsuz etkiler. Bu nedenle sporcular tarafından yüksek şiddetli egzersizlerde bozulabilecek asit-baz homeostazı için destekleyici besinsel takviyelerin kullanılması (sodyum bikarbonat, sodyum sitrat, beta alanin vb.) sportif performansın optimal biçimde sürdürülebilmesi, oluşabilecek yorgunluğun geciktirilebilmesi ve performansın artırılması için tavsiye edilen alternatiflerdir.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":97824795,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97824795/thumbnails/1.jpg","file_name":"Gencoglu_C._et_al._Egzersizde_Asit_Baz_Homeostazi_Bir_Geleneksel_Derleme_Ulusal_Spor_Bilimleri_Dergisi_2022.pdf","download_url":"https://www.academia.edu/attachments/97824795/download_file?st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Ulusal_Spor_Bilimleri_Dergisi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97824795/Gencoglu_C._et_al._Egzersizde_Asit_Baz_Homeostazi_Bir_Geleneksel_Derleme_Ulusal_Spor_Bilimleri_Dergisi_2022-libre.pdf?1674731356=\u0026response-content-disposition=attachment%3B+filename%3DUlusal_Spor_Bilimleri_Dergisi.pdf\u0026Expires=1734541248\u0026Signature=G22S-3mNS7ZxM~UI845hx~CjLw93BV-RMNRY3wTedIVKjmqgBEhSU2N7hxvNpxjJHrrM8J~TpjZxcAmg9xSfGKkGaa8nL35q4pSjI2V43RDacg2aFknhfx9IoBrJkIhv21b5QeWmj8Kuu5d9l3flqplaYKdJWQbToKrQDVy~bnGMX-ELqtdj3Sab4~rF7NF1mBp2qecduslgDtyy2eo2k4fS-OdMy2h9ohxSy7ACqLeKrrpwEvrcJEX-A6hGfbh5iLTZoL6LyeXOqt2O6dXCEO1bp8wrBYVp6pT5rliWUVEwVIHEa6giL~V~tYbvVnLYN4uRUxNjO08ez2BpBKRy3Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539837"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539837/Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles"><img alt="Research paper thumbnail of Increased Susceptibility to Apoptosis and Growth Arrest of Human Breast Cancer Cells Treated by a Snake Venom-Loaded Silica Nanoparticles" class="work-thumbnail" src="https://attachments.academia-assets.com/93326910/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539837/Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles">Increased Susceptibility to Apoptosis and Growth Arrest of Human Breast Cancer Cells Treated by a Snake Venom-Loaded Silica Nanoparticles</a></div><div class="wp-workCard_item"><span>Cellular Physiology and Biochemistry</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (<a href="http://www.karger.com/OA-license" rel="nofollow">www.karger.com/OA-license</a>), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="56695fd4ce5f452f5cc725a284bc39a0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326910,"asset_id":89539837,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326910/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539837"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539837"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539837; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539837]").text(description); $(".js-view-count[data-work-id=89539837]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539837; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539837']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539837, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "56695fd4ce5f452f5cc725a284bc39a0" } } $('.js-work-strip[data-work-id=89539837]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539837,"title":"Increased Susceptibility to Apoptosis and Growth Arrest of Human Breast Cancer Cells Treated by a Snake Venom-Loaded Silica Nanoparticles","translated_title":"","metadata":{"publisher":"S. Karger AG","ai_title_tag":"Snake Venom-Loaded Silica Nanoparticles Induce Breast Cancer Cell Death","grobid_abstract":"This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Cellular Physiology and Biochemistry","grobid_abstract_attachment_id":93326910},"translated_abstract":null,"internal_url":"https://www.academia.edu/89539837/Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles","translated_internal_url":"","created_at":"2022-10-30T09:48:20.758-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326910,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326910/thumbnails/1.jpg","file_name":"366366.pdf","download_url":"https://www.academia.edu/attachments/93326910/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Increased_Susceptibility_to_Apoptosis_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326910/366366-libre.pdf?1667150906=\u0026response-content-disposition=attachment%3B+filename%3DIncreased_Susceptibility_to_Apoptosis_an.pdf\u0026Expires=1734541249\u0026Signature=grjC4zM90Yq6cgtdqTrWkRYyePo8FU2dz6f4uhd4YWb4qNGUgiyIoofYO1bDSRF2p05grreRcuOQQ63aun3-naJwprGFtkJb2xoV86uzJB82LHqtVWBeh1FH8oeGhJYRY9xU5j6aWrHMIXFLYnpV7UITJZ3vY7SS8Qn9B2dTKj~HV7e9PHhbpWj~jDZ4HRDP0Umn-7wBmvvb51a84sqdWo9qaPQl6MT4xQPiYZ83sKPxzveA1nkVN45NYdc5NY~9FdU1mUCPjxROLhQXDV2UWJj7n~S0N6dONJ8ANN0nryhpEXwAy-RUb85btxdmExZtM8QSPPY8WeHMU0HZVLX5rQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles","translated_slug":"","page_count":12,"language":"en","content_type":"Work","summary":"This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326910,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326910/thumbnails/1.jpg","file_name":"366366.pdf","download_url":"https://www.academia.edu/attachments/93326910/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Increased_Susceptibility_to_Apoptosis_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326910/366366-libre.pdf?1667150906=\u0026response-content-disposition=attachment%3B+filename%3DIncreased_Susceptibility_to_Apoptosis_an.pdf\u0026Expires=1734541249\u0026Signature=grjC4zM90Yq6cgtdqTrWkRYyePo8FU2dz6f4uhd4YWb4qNGUgiyIoofYO1bDSRF2p05grreRcuOQQ63aun3-naJwprGFtkJb2xoV86uzJB82LHqtVWBeh1FH8oeGhJYRY9xU5j6aWrHMIXFLYnpV7UITJZ3vY7SS8Qn9B2dTKj~HV7e9PHhbpWj~jDZ4HRDP0Umn-7wBmvvb51a84sqdWo9qaPQl6MT4xQPiYZ83sKPxzveA1nkVN45NYdc5NY~9FdU1mUCPjxROLhQXDV2UWJj7n~S0N6dONJ8ANN0nryhpEXwAy-RUb85btxdmExZtM8QSPPY8WeHMU0HZVLX5rQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":25315059,"url":"https://www.karger.com/Article/Pdf/366366"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539257"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539257/Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds"><img alt="Research paper thumbnail of Synthesis and Cytotoxicity of Novel 3-Aryl-1-(3′-dibenzylaminomethyl-4′-hydroxyphenyl)-propenones and Related Compounds" class="work-thumbnail" src="https://attachments.academia-assets.com/93326471/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539257/Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds">Synthesis and Cytotoxicity of Novel 3-Aryl-1-(3′-dibenzylaminomethyl-4′-hydroxyphenyl)-propenones and Related Compounds</a></div><div class="wp-workCard_item"><span>CHEMICAL &amp; PHARMACEUTICAL BULLETIN</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to the formation of a novel series of 4-hydroxy-3-dibenzylaminomethyl chalcones (7a-e) instead of 4-hydroxy-3,5bis-(dibenzylaminomethyl)chalcones 4. In order to rationalise the formation of monoadduct 7, energy minimized model structures of 4a and 7a were compared. The in vitro cytotoxic activities of 7a-e were tested against PC-3 cell lines for the first time in this study and compared with the precursor 4-hydroxychalcones (1a-e). Except for compound 7a (IC 50 : 19.85 m mM), insertion of dibenzylaminomethyl function into 4-hydroxychalcones resulted in complete loss of cytotoxic activity. The results suggested that it is not only the pK a but also the shape and size of the amine that is critical in governing the cytotoxic activity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ebd02786c28d173e60a596cffaee578f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326471,"asset_id":89539257,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326471/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539257"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539257"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539257; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539257]").text(description); $(".js-view-count[data-work-id=89539257]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539257; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539257']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539257, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ebd02786c28d173e60a596cffaee578f" } } $('.js-work-strip[data-work-id=89539257]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539257,"title":"Synthesis and Cytotoxicity of Novel 3-Aryl-1-(3′-dibenzylaminomethyl-4′-hydroxyphenyl)-propenones and Related Compounds","translated_title":"","metadata":{"publisher":"Pharmaceutical Society of Japan","grobid_abstract":"The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to the formation of a novel series of 4-hydroxy-3-dibenzylaminomethyl chalcones (7a-e) instead of 4-hydroxy-3,5bis-(dibenzylaminomethyl)chalcones 4. In order to rationalise the formation of monoadduct 7, energy minimized model structures of 4a and 7a were compared. The in vitro cytotoxic activities of 7a-e were tested against PC-3 cell lines for the first time in this study and compared with the precursor 4-hydroxychalcones (1a-e). Except for compound 7a (IC 50 : 19.85 m mM), insertion of dibenzylaminomethyl function into 4-hydroxychalcones resulted in complete loss of cytotoxic activity. The results suggested that it is not only the pK a but also the shape and size of the amine that is critical in governing the cytotoxic activity.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"CHEMICAL \u0026amp; PHARMACEUTICAL BULLETIN","grobid_abstract_attachment_id":93326471},"translated_abstract":null,"internal_url":"https://www.academia.edu/89539257/Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds","translated_internal_url":"","created_at":"2022-10-30T09:38:58.928-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326471,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326471/thumbnails/1.jpg","file_name":"_pdf.pdf","download_url":"https://www.academia.edu/attachments/93326471/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Synthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326471/_pdf-libre.pdf?1667150915=\u0026response-content-disposition=attachment%3B+filename%3DSynthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf\u0026Expires=1734541249\u0026Signature=ctwiLfDG7W2xSSPCPmejZEUoUWRKkOZRn0Ku4x~7Q3CZmDRVHW6GY6g3cBLFGSBFNpRjKakZQJrG4XR5Z5YIYwOkoOV9dPmY6dUPKEezQ-XZg9Ve-8eCb68YOeWt286FjlayiQ21jH0hZbkSfBEfrZxh-fVx4~j76GBJRbFX3swCf4FEOEU~6dxh6LL-Ow3x-3AgE4ynrygNr-1Oor8aowYOgbCk0aHtfylxMRNVWnIAwF1lqCqQBAOQDsMX5iY0m-gmg~X-VxVbbEnV6g3N~QSOtMlcAU~Bqn9j3GKcuIOtFs--5kyGJu68eYf80iH9oRHY4uxDtggVzrBppWbnKg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds","translated_slug":"","page_count":7,"language":"en","content_type":"Work","summary":"The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to the formation of a novel series of 4-hydroxy-3-dibenzylaminomethyl chalcones (7a-e) instead of 4-hydroxy-3,5bis-(dibenzylaminomethyl)chalcones 4. In order to rationalise the formation of monoadduct 7, energy minimized model structures of 4a and 7a were compared. The in vitro cytotoxic activities of 7a-e were tested against PC-3 cell lines for the first time in this study and compared with the precursor 4-hydroxychalcones (1a-e). Except for compound 7a (IC 50 : 19.85 m mM), insertion of dibenzylaminomethyl function into 4-hydroxychalcones resulted in complete loss of cytotoxic activity. The results suggested that it is not only the pK a but also the shape and size of the amine that is critical in governing the cytotoxic activity.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326471,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326471/thumbnails/1.jpg","file_name":"_pdf.pdf","download_url":"https://www.academia.edu/attachments/93326471/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Synthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326471/_pdf-libre.pdf?1667150915=\u0026response-content-disposition=attachment%3B+filename%3DSynthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf\u0026Expires=1734541249\u0026Signature=ctwiLfDG7W2xSSPCPmejZEUoUWRKkOZRn0Ku4x~7Q3CZmDRVHW6GY6g3cBLFGSBFNpRjKakZQJrG4XR5Z5YIYwOkoOV9dPmY6dUPKEezQ-XZg9Ve-8eCb68YOeWt286FjlayiQ21jH0hZbkSfBEfrZxh-fVx4~j76GBJRbFX3swCf4FEOEU~6dxh6LL-Ow3x-3AgE4ynrygNr-1Oor8aowYOgbCk0aHtfylxMRNVWnIAwF1lqCqQBAOQDsMX5iY0m-gmg~X-VxVbbEnV6g3N~QSOtMlcAU~Bqn9j3GKcuIOtFs--5kyGJu68eYf80iH9oRHY4uxDtggVzrBppWbnKg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":12597,"name":"Crystallization","url":"https://www.academia.edu/Documents/in/Crystallization"},{"id":14054,"name":"Chemical","url":"https://www.academia.edu/Documents/in/Chemical"},{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy"},{"id":22050,"name":"Cytotoxicity","url":"https://www.academia.edu/Documents/in/Cytotoxicity"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":114715,"name":"Stereochemistry","url":"https://www.academia.edu/Documents/in/Stereochemistry"},{"id":184989,"name":"Carcinogens","url":"https://www.academia.edu/Documents/in/Carcinogens"},{"id":309949,"name":"Propane","url":"https://www.academia.edu/Documents/in/Propane"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":1162913,"name":"Mutagens","url":"https://www.academia.edu/Documents/in/Mutagens"},{"id":1271583,"name":"Aryl","url":"https://www.academia.edu/Documents/in/Aryl"},{"id":2898895,"name":"binding sites","url":"https://www.academia.edu/Documents/in/binding_sites"},{"id":3024741,"name":"ketones","url":"https://www.academia.edu/Documents/in/ketones"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":25314789,"url":"https://www.jstage.jst.go.jp/article/cpb/56/12/56_12_1675/_pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539210"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539210/Sorafenib_alleviates_inflammatory_signaling_of_tumor_microenvironment_in_lung_cancer"><img alt="Research paper thumbnail of Sorafenib alleviates inflammatory signaling of tumor microenvironment in lung cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/93326348/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539210/Sorafenib_alleviates_inflammatory_signaling_of_tumor_microenvironment_in_lung_cancer">Sorafenib alleviates inflammatory signaling of tumor microenvironment in lung cancer</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: This study was designed to assess the possible beneficial effects of sorafenib (SOR) ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: This study was designed to assess the possible beneficial effects of sorafenib (SOR) in diethylnitrosamine (DEN) induced lung carcinogenesis in male rats and also to examine its probable mechanisms of action. Methods and results: A total of 30 adult male rats were divided into three groups as (1) control, (2) DEN, and (3) DEN+SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum samples were analyzed to determine SOX2 levels. Levels of SOX2, TNF-α and IL-1β were measured in lung tissue supernatants. Lung sections were evaluated histopathologically. Also, COX-2 and JNK were analyzed by immunohistochemistry and immunofluorescence methods respectively. SOR reduced the level of SOX2 that maintenance of cancer stemness and tumorigenicity, and TNF-α and IL-1β levels. Furthermore, SOR ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="994abb0b02db94effb8c0310b9d4af22" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326348,"asset_id":89539210,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326348/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539210"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539210"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539210; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539210]").text(description); $(".js-view-count[data-work-id=89539210]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539210; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539210']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539210, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "994abb0b02db94effb8c0310b9d4af22" } } $('.js-work-strip[data-work-id=89539210]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539210,"title":"Sorafenib alleviates inflammatory signaling of tumor microenvironment in lung cancer","translated_title":"","metadata":{"abstract":"Background: This study was designed to assess the possible beneficial effects of sorafenib (SOR) in diethylnitrosamine (DEN) induced lung carcinogenesis in male rats and also to examine its probable mechanisms of action. Methods and results: A total of 30 adult male rats were divided into three groups as (1) control, (2) DEN, and (3) DEN+SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum samples were analyzed to determine SOX2 levels. Levels of SOX2, TNF-α and IL-1β were measured in lung tissue supernatants. Lung sections were evaluated histopathologically. Also, COX-2 and JNK were analyzed by immunohistochemistry and immunofluorescence methods respectively. SOR reduced the level of SOX2 that maintenance of cancer stemness and tumorigenicity, and TNF-α and IL-1β levels. Furthermore, SOR ...","publisher":"Research Square Platform LLC"},"translated_abstract":"Background: This study was designed to assess the possible beneficial effects of sorafenib (SOR) in diethylnitrosamine (DEN) induced lung carcinogenesis in male rats and also to examine its probable mechanisms of action. Methods and results: A total of 30 adult male rats were divided into three groups as (1) control, (2) DEN, and (3) DEN+SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum samples were analyzed to determine SOX2 levels. Levels of SOX2, TNF-α and IL-1β were measured in lung tissue supernatants. Lung sections were evaluated histopathologically. Also, COX-2 and JNK were analyzed by immunohistochemistry and immunofluorescence methods respectively. SOR reduced the level of SOX2 that maintenance of cancer stemness and tumorigenicity, and TNF-α and IL-1β levels. Furthermore, SOR ...","internal_url":"https://www.academia.edu/89539210/Sorafenib_alleviates_inflammatory_signaling_of_tumor_microenvironment_in_lung_cancer","translated_internal_url":"","created_at":"2022-10-30T09:38:05.193-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326348,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326348/thumbnails/1.jpg","file_name":"latest.pdf","download_url":"https://www.academia.edu/attachments/93326348/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Sorafenib_alleviates_inflammatory_signal.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326348/latest-libre.pdf?1667150937=\u0026response-content-disposition=attachment%3B+filename%3DSorafenib_alleviates_inflammatory_signal.pdf\u0026Expires=1734541249\u0026Signature=ATq4ezArU11bAU6e0TmsgKSGeVeHNMfLcjLlQJi4NTupCZ9gEueV5~Bs7K1iU7BGtsbSj10qv2mGlEce22dbdWaeQSrJ0tCyyx7lb8o4VN0J7rVodIiwUJW7oniCLDGwXUPkrHQK8LjNv6FMTjW8vm1-hXXaJ5KH~Qheb9RpbKOB1z489oKLaeN77ufTYQBtdZaJNlFlqT2FL0VYbjnube24x7gsZidXOWW58rqLqXcxAuf0snVeCt6uqv0VWE1vhkw1gJzxbAk8CUMATsnVUpmQS~wYiguz9BY4t2RD7mFzR92IrmgEc8nCnppIZ3oQiRPi23it3xF3pcrqPEg6Og__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Sorafenib_alleviates_inflammatory_signaling_of_tumor_microenvironment_in_lung_cancer","translated_slug":"","page_count":14,"language":"en","content_type":"Work","summary":"Background: This study was designed to assess the possible beneficial effects of sorafenib (SOR) in diethylnitrosamine (DEN) induced lung carcinogenesis in male rats and also to examine its probable mechanisms of action. Methods and results: A total of 30 adult male rats were divided into three groups as (1) control, (2) DEN, and (3) DEN+SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum samples were analyzed to determine SOX2 levels. Levels of SOX2, TNF-α and IL-1β were measured in lung tissue supernatants. Lung sections were evaluated histopathologically. Also, COX-2 and JNK were analyzed by immunohistochemistry and immunofluorescence methods respectively. SOR reduced the level of SOX2 that maintenance of cancer stemness and tumorigenicity, and TNF-α and IL-1β levels. Furthermore, SOR ...","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326348,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326348/thumbnails/1.jpg","file_name":"latest.pdf","download_url":"https://www.academia.edu/attachments/93326348/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Sorafenib_alleviates_inflammatory_signal.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326348/latest-libre.pdf?1667150937=\u0026response-content-disposition=attachment%3B+filename%3DSorafenib_alleviates_inflammatory_signal.pdf\u0026Expires=1734541249\u0026Signature=ATq4ezArU11bAU6e0TmsgKSGeVeHNMfLcjLlQJi4NTupCZ9gEueV5~Bs7K1iU7BGtsbSj10qv2mGlEce22dbdWaeQSrJ0tCyyx7lb8o4VN0J7rVodIiwUJW7oniCLDGwXUPkrHQK8LjNv6FMTjW8vm1-hXXaJ5KH~Qheb9RpbKOB1z489oKLaeN77ufTYQBtdZaJNlFlqT2FL0VYbjnube24x7gsZidXOWW58rqLqXcxAuf0snVeCt6uqv0VWE1vhkw1gJzxbAk8CUMATsnVUpmQS~wYiguz9BY4t2RD7mFzR92IrmgEc8nCnppIZ3oQiRPi23it3xF3pcrqPEg6Og__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51698,"name":"Lung Cancer","url":"https://www.academia.edu/Documents/in/Lung_Cancer"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung"},{"id":340262,"name":"Carcinogenesis","url":"https://www.academia.edu/Documents/in/Carcinogenesis"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha"},{"id":1003057,"name":"Sorafenib","url":"https://www.academia.edu/Documents/in/Sorafenib"},{"id":1137385,"name":"Sox","url":"https://www.academia.edu/Documents/in/Sox"}],"urls":[{"id":25314614,"url":"https://www.researchsquare.com/article/rs-1219452/v2"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539208"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539208/Monoamine_Oxidase_MAO_as_a_Potential_Target_for_Anticancer_Drug_Design_and_Development"><img alt="Research paper thumbnail of Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development" class="work-thumbnail" src="https://attachments.academia-assets.com/93326285/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539208/Monoamine_Oxidase_MAO_as_a_Potential_Target_for_Anticancer_Drug_Design_and_Development">Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development</a></div><div class="wp-workCard_item"><span>Molecules</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination. Owing to the crucial role of MAOs in maintaining functional levels of neurotransmitters, the implications of its distorted activity have been associated with numerous neurological diseases. Recently, an unanticipated role of MAOs in tumor progression and metastasis has been reported. The chemical inhibition of MAOs might be a valuable therapeutic approach for cancer treatment. In this review, we reported computational approaches exploited in the design and development of selective MAO inhibitors accompanied by their biological activities. Additionally, we generated a pharmacophore model for MAO-A active inhibitors to identify the structural motifs to invoke an activity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a087fbca926c4f5eb0eec1b626c1acb0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326285,"asset_id":89539208,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326285/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539208"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539208"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539208; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539208]").text(description); $(".js-view-count[data-work-id=89539208]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539208; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539208']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539208, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a087fbca926c4f5eb0eec1b626c1acb0" } } $('.js-work-strip[data-work-id=89539208]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539208,"title":"Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development","translated_title":"","metadata":{"abstract":"Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination. Owing to the crucial role of MAOs in maintaining functional levels of neurotransmitters, the implications of its distorted activity have been associated with numerous neurological diseases. Recently, an unanticipated role of MAOs in tumor progression and metastasis has been reported. The chemical inhibition of MAOs might be a valuable therapeutic approach for cancer treatment. In this review, we reported computational approaches exploited in the design and development of selective MAO inhibitors accompanied by their biological activities. Additionally, we generated a pharmacophore model for MAO-A active inhibitors to identify the structural motifs to invoke an activity.","publisher":"MDPI AG","ai_title_tag":"MAO Inhibitors: A New Frontier in Anticancer Drug Design","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Molecules"},"translated_abstract":"Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination. Owing to the crucial role of MAOs in maintaining functional levels of neurotransmitters, the implications of its distorted activity have been associated with numerous neurological diseases. Recently, an unanticipated role of MAOs in tumor progression and metastasis has been reported. The chemical inhibition of MAOs might be a valuable therapeutic approach for cancer treatment. In this review, we reported computational approaches exploited in the design and development of selective MAO inhibitors accompanied by their biological activities. Additionally, we generated a pharmacophore model for MAO-A active inhibitors to identify the structural motifs to invoke an activity.","internal_url":"https://www.academia.edu/89539208/Monoamine_Oxidase_MAO_as_a_Potential_Target_for_Anticancer_Drug_Design_and_Development","translated_internal_url":"","created_at":"2022-10-30T09:38:05.060-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326285,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326285/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/93326285/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Monoamine_Oxidase_MAO_as_a_Potential_Tar.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326285/pdf-libre.pdf?1667150953=\u0026response-content-disposition=attachment%3B+filename%3DMonoamine_Oxidase_MAO_as_a_Potential_Tar.pdf\u0026Expires=1734541249\u0026Signature=hDvMmm0FzBN47BEJE824hF~fKZMVbiTBkfv8~4EKPE0TegJ9YCq16klSClYYeMzCRC0eyRBLbcQi1wYw~xxt6NsDz~T75rUksJ5wNJbLXQuboRKj5y3wPBjFb4t7JLBy2lvNgkjMePpu0upIcr2d3OlZeGuNilDnCB3GkgT44Z4ymscxhH2J-fjkY36Mhk-OZstM0CYYuMiE6MWyYdqtQud6TeVE2axzNB3yBA-qrv50jopieni3r5KMSd6XV4JcOQdtc~ERbVaHZlSj0NY6Mkv82kYvZ5kVcIvdnvDQgMB6cfMjaQrZCdMa8awM5JWhNN33wlB9118vZBWKKnJrBw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Monoamine_Oxidase_MAO_as_a_Potential_Target_for_Anticancer_Drug_Design_and_Development","translated_slug":"","page_count":19,"language":"en","content_type":"Work","summary":"Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination. Owing to the crucial role of MAOs in maintaining functional levels of neurotransmitters, the implications of its distorted activity have been associated with numerous neurological diseases. Recently, an unanticipated role of MAOs in tumor progression and metastasis has been reported. The chemical inhibition of MAOs might be a valuable therapeutic approach for cancer treatment. In this review, we reported computational approaches exploited in the design and development of selective MAO inhibitors accompanied by their biological activities. Additionally, we generated a pharmacophore model for MAO-A active inhibitors to identify the structural motifs to invoke an activity.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326285,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326285/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/93326285/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Monoamine_Oxidase_MAO_as_a_Potential_Tar.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326285/pdf-libre.pdf?1667150953=\u0026response-content-disposition=attachment%3B+filename%3DMonoamine_Oxidase_MAO_as_a_Potential_Tar.pdf\u0026Expires=1734541249\u0026Signature=hDvMmm0FzBN47BEJE824hF~fKZMVbiTBkfv8~4EKPE0TegJ9YCq16klSClYYeMzCRC0eyRBLbcQi1wYw~xxt6NsDz~T75rUksJ5wNJbLXQuboRKj5y3wPBjFb4t7JLBy2lvNgkjMePpu0upIcr2d3OlZeGuNilDnCB3GkgT44Z4ymscxhH2J-fjkY36Mhk-OZstM0CYYuMiE6MWyYdqtQud6TeVE2axzNB3yBA-qrv50jopieni3r5KMSd6XV4JcOQdtc~ERbVaHZlSj0NY6Mkv82kYvZ5kVcIvdnvDQgMB6cfMjaQrZCdMa8awM5JWhNN33wlB9118vZBWKKnJrBw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":328449,"name":"Molecules","url":"https://www.academia.edu/Documents/in/Molecules"},{"id":350932,"name":"Oxidative Deamination","url":"https://www.academia.edu/Documents/in/Oxidative_Deamination"},{"id":1243420,"name":"Monoamine oxidase","url":"https://www.academia.edu/Documents/in/Monoamine_oxidase"},{"id":1337586,"name":"Pharmacophore","url":"https://www.academia.edu/Documents/in/Pharmacophore"}],"urls":[{"id":25314612,"url":"https://www.mdpi.com/1420-3049/26/19/6019/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539206"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539206/Is_Oxytocin_Proper_for_Cancer_Adjuvant_Therapy"><img alt="Research paper thumbnail of Is Oxytocin Proper for Cancer Adjuvant Therapy?" class="work-thumbnail" src="https://attachments.academia-assets.com/93326284/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539206/Is_Oxytocin_Proper_for_Cancer_Adjuvant_Therapy">Is Oxytocin Proper for Cancer Adjuvant Therapy?</a></div><div class="wp-workCard_item"><span>Proceedings</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Neuroblastomas are solid tumors and mostly seen in the adrenal medulla and sympathetic ganglia. I...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Neuroblastomas are solid tumors and mostly seen in the adrenal medulla and sympathetic ganglia. It is known that neuroblastoma cell proliferation is inhibited by cisplatin and vincristine. The aim of this study was to investigate the effect of oxytocin on cell viability in human neuroblastoma SH-SY5Y cell line and primary cerebral cortex cell culture exposed to cisplatin and vincristine. In this direction, SH-SY5Y cell line and cortex neurons were obtained from the medical pharmacology department, Ataturk University. Both cells were grown in the appropriate cell culture media. Cisplatin (5, 10, 15 μg), vincristine (0.5, 1 and 2 ng) and oxytocin (1 μM) were applied to SH-SY5Y cell line and primary cortex cell culture for 24 h. MTT and TAC-TOS tests were performed 24 h after the application. As a result of the MTT assay, the combination of cisplatin and vincristine reduced cell viability in both cultures approximately 25% and 22%, respectively, compared to the control group. It appear...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9cae56ffddcd0edf9720a2830fd17774" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326284,"asset_id":89539206,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326284/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539206"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539206"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539206; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539206]").text(description); $(".js-view-count[data-work-id=89539206]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539206; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539206']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539206, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9cae56ffddcd0edf9720a2830fd17774" } } $('.js-work-strip[data-work-id=89539206]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539206,"title":"Is Oxytocin Proper for Cancer Adjuvant Therapy?","translated_title":"","metadata":{"abstract":"Neuroblastomas are solid tumors and mostly seen in the adrenal medulla and sympathetic ganglia. It is known that neuroblastoma cell proliferation is inhibited by cisplatin and vincristine. The aim of this study was to investigate the effect of oxytocin on cell viability in human neuroblastoma SH-SY5Y cell line and primary cerebral cortex cell culture exposed to cisplatin and vincristine. In this direction, SH-SY5Y cell line and cortex neurons were obtained from the medical pharmacology department, Ataturk University. Both cells were grown in the appropriate cell culture media. Cisplatin (5, 10, 15 μg), vincristine (0.5, 1 and 2 ng) and oxytocin (1 μM) were applied to SH-SY5Y cell line and primary cortex cell culture for 24 h. MTT and TAC-TOS tests were performed 24 h after the application. As a result of the MTT assay, the combination of cisplatin and vincristine reduced cell viability in both cultures approximately 25% and 22%, respectively, compared to the control group. It appear...","publisher":"MDPI AG","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Proceedings"},"translated_abstract":"Neuroblastomas are solid tumors and mostly seen in the adrenal medulla and sympathetic ganglia. It is known that neuroblastoma cell proliferation is inhibited by cisplatin and vincristine. The aim of this study was to investigate the effect of oxytocin on cell viability in human neuroblastoma SH-SY5Y cell line and primary cerebral cortex cell culture exposed to cisplatin and vincristine. In this direction, SH-SY5Y cell line and cortex neurons were obtained from the medical pharmacology department, Ataturk University. Both cells were grown in the appropriate cell culture media. Cisplatin (5, 10, 15 μg), vincristine (0.5, 1 and 2 ng) and oxytocin (1 μM) were applied to SH-SY5Y cell line and primary cortex cell culture for 24 h. MTT and TAC-TOS tests were performed 24 h after the application. As a result of the MTT assay, the combination of cisplatin and vincristine reduced cell viability in both cultures approximately 25% and 22%, respectively, compared to the control group. It appear...","internal_url":"https://www.academia.edu/89539206/Is_Oxytocin_Proper_for_Cancer_Adjuvant_Therapy","translated_internal_url":"","created_at":"2022-10-30T09:38:04.936-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326284,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326284/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/93326284/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Is_Oxytocin_Proper_for_Cancer_Adjuvant_T.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326284/pdf-libre.pdf?1667150947=\u0026response-content-disposition=attachment%3B+filename%3DIs_Oxytocin_Proper_for_Cancer_Adjuvant_T.pdf\u0026Expires=1734541249\u0026Signature=JCm1rBXZAh~8kL6EoFyRLazkm1XmYw4EzuUYxfsh35PJ42zT4VYHcDvjcHtkg0jJ1MlsY3iRZDJiGTA5IlWy7elNfcLl7MAOn-XnXYaVw-On9LLJ3QSHutBUSxPjXOFb1OG~QVEX0amY2ZknJKIU8ECw6Kl237aTP3tu7q93lvWUhhmbMQnJwowTk~npZ3BhY7ZqpFViIrNq~BPB9OARBJqnULYsxnBP0HKqEWt8O854s-x-h2E7nVHHb93suOxeZcuNBPSOkvZEGHC-6fD0BDchYIsP2WG9XUaGjSKNUy2FdIFSqwgAutItSgGD52ggPTTpK3FAxBYOVBr5mOPPEQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Is_Oxytocin_Proper_for_Cancer_Adjuvant_Therapy","translated_slug":"","page_count":4,"language":"en","content_type":"Work","summary":"Neuroblastomas are solid tumors and mostly seen in the adrenal medulla and sympathetic ganglia. It is known that neuroblastoma cell proliferation is inhibited by cisplatin and vincristine. The aim of this study was to investigate the effect of oxytocin on cell viability in human neuroblastoma SH-SY5Y cell line and primary cerebral cortex cell culture exposed to cisplatin and vincristine. In this direction, SH-SY5Y cell line and cortex neurons were obtained from the medical pharmacology department, Ataturk University. Both cells were grown in the appropriate cell culture media. Cisplatin (5, 10, 15 μg), vincristine (0.5, 1 and 2 ng) and oxytocin (1 μM) were applied to SH-SY5Y cell line and primary cortex cell culture for 24 h. MTT and TAC-TOS tests were performed 24 h after the application. As a result of the MTT assay, the combination of cisplatin and vincristine reduced cell viability in both cultures approximately 25% and 22%, respectively, compared to the control group. It appear...","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326284,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326284/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/93326284/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Is_Oxytocin_Proper_for_Cancer_Adjuvant_T.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326284/pdf-libre.pdf?1667150947=\u0026response-content-disposition=attachment%3B+filename%3DIs_Oxytocin_Proper_for_Cancer_Adjuvant_T.pdf\u0026Expires=1734541249\u0026Signature=JCm1rBXZAh~8kL6EoFyRLazkm1XmYw4EzuUYxfsh35PJ42zT4VYHcDvjcHtkg0jJ1MlsY3iRZDJiGTA5IlWy7elNfcLl7MAOn-XnXYaVw-On9LLJ3QSHutBUSxPjXOFb1OG~QVEX0amY2ZknJKIU8ECw6Kl237aTP3tu7q93lvWUhhmbMQnJwowTk~npZ3BhY7ZqpFViIrNq~BPB9OARBJqnULYsxnBP0HKqEWt8O854s-x-h2E7nVHHb93suOxeZcuNBPSOkvZEGHC-6fD0BDchYIsP2WG9XUaGjSKNUy2FdIFSqwgAutItSgGD52ggPTTpK3FAxBYOVBr5mOPPEQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":93326283,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326283/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/93326283/download_file","bulk_download_file_name":"Is_Oxytocin_Proper_for_Cancer_Adjuvant_T.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326283/pdf-libre.pdf?1667150949=\u0026response-content-disposition=attachment%3B+filename%3DIs_Oxytocin_Proper_for_Cancer_Adjuvant_T.pdf\u0026Expires=1734541249\u0026Signature=SMy7yVYOlcs4oBDZre8Plg8lQoPhYXS-bLAly7h8jsA9SrD8dRrYvLRU-qrTFeaLTuwELsDYUiLIpgp3SxCnk7dQNhkkAvbHetzCsT59LlPFTs5oP9H2AXn5O-xzkWIqiAnvOCrLb1ZYQYWFcMCm5hQG6E78SgWATNVTt69cxPzA2Hd9q7MclakNxPzB7Vkbua3gtlHwxyR48g5XLDfD9nGlyqKQ1pLJDbANvHsbu0-C232-fEBt9uD~pA9kkpdzbLxfto3dqQ4Crh7K4l8u4CP~1jCVsG7EHd2-syY9tbpg2JHUTTPjEtvhXecZp-7Hc5EXc-PPQb2i~Zko8fzNLg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":40276,"name":"Proceedings","url":"https://www.academia.edu/Documents/in/Proceedings"},{"id":53735,"name":"Oxytocin","url":"https://www.academia.edu/Documents/in/Oxytocin"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":1485245,"name":"Adjuvant","url":"https://www.academia.edu/Documents/in/Adjuvant"}],"urls":[{"id":25314610,"url":"http://www.mdpi.com/2504-3900/2/25/1582/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539205"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539205/The_Codes_of_Publication_Policy_of_the_Eurasian_Journal_of_Medicine_Parameters_for_a_Stable_and_Sustainable_Journal"><img alt="Research paper thumbnail of The Codes of Publication Policy of the Eurasian Journal of Medicine: Parameters for a Stable and Sustainable Journal" class="work-thumbnail" src="https://attachments.academia-assets.com/93326346/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539205/The_Codes_of_Publication_Policy_of_the_Eurasian_Journal_of_Medicine_Parameters_for_a_Stable_and_Sustainable_Journal">The Codes of Publication Policy of the Eurasian Journal of Medicine: Parameters for a Stable and Sustainable Journal</a></div><div class="wp-workCard_item"><span>The Eurasian Journal of Medicine</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7ef7aabecfadfb6d8fd34d559038a862" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326346,"asset_id":89539205,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326346/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539205"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539205"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539205; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539205]").text(description); $(".js-view-count[data-work-id=89539205]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539205; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539205']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539205, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7ef7aabecfadfb6d8fd34d559038a862" } } $('.js-work-strip[data-work-id=89539205]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539205,"title":"The Codes of Publication Policy of the Eurasian Journal of Medicine: Parameters for a Stable and Sustainable Journal","translated_title":"","metadata":{"publisher":"AVES Publishing Co.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"The Eurasian Journal of Medicine"},"translated_abstract":null,"internal_url":"https://www.academia.edu/89539205/The_Codes_of_Publication_Policy_of_the_Eurasian_Journal_of_Medicine_Parameters_for_a_Stable_and_Sustainable_Journal","translated_internal_url":"","created_at":"2022-10-30T09:38:04.842-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326346,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326346/thumbnails/1.jpg","file_name":"e80333989cbf5e07c6015e1236ebd1cc65fd.pdf","download_url":"https://www.academia.edu/attachments/93326346/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Codes_of_Publication_Policy_of_the_E.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326346/e80333989cbf5e07c6015e1236ebd1cc65fd-libre.pdf?1667150928=\u0026response-content-disposition=attachment%3B+filename%3DThe_Codes_of_Publication_Policy_of_the_E.pdf\u0026Expires=1734541249\u0026Signature=A78KFDu0v7zR4JAW~ADmsLfFohI-XnDb3DDxg74KY9cdPUVeE~OoxLIWsDVCKPR6VSik~zf2yvu2yTctMXg3F0b3vJEZtLXXgadpQA8OFeTxVqrSBvObagHrJrMDkvif~iFPrUoU6KVaNZ1GkiwhfEOq08jSGvN2C-GZ9BpuClKjlMGzuxdL~m0R7luiwnYBFRQh5mOmQDaT9oflSpHmXqik8et17HRIVFvwM~g~hnSD8arxzfTMGBhhqwz-IB0zKDKBKOqNy~h8Sn2~D4BVGGLsa7BzgakjvB8Zo-fRwYmrtxa-2cGTgEkeirG8tjVerjPjr4~J3hdNYK-MVxdYWg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Codes_of_Publication_Policy_of_the_Eurasian_Journal_of_Medicine_Parameters_for_a_Stable_and_Sustainable_Journal","translated_slug":"","page_count":1,"language":"en","content_type":"Work","summary":null,"owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326346,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326346/thumbnails/1.jpg","file_name":"e80333989cbf5e07c6015e1236ebd1cc65fd.pdf","download_url":"https://www.academia.edu/attachments/93326346/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Codes_of_Publication_Policy_of_the_E.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326346/e80333989cbf5e07c6015e1236ebd1cc65fd-libre.pdf?1667150928=\u0026response-content-disposition=attachment%3B+filename%3DThe_Codes_of_Publication_Policy_of_the_E.pdf\u0026Expires=1734541249\u0026Signature=A78KFDu0v7zR4JAW~ADmsLfFohI-XnDb3DDxg74KY9cdPUVeE~OoxLIWsDVCKPR6VSik~zf2yvu2yTctMXg3F0b3vJEZtLXXgadpQA8OFeTxVqrSBvObagHrJrMDkvif~iFPrUoU6KVaNZ1GkiwhfEOq08jSGvN2C-GZ9BpuClKjlMGzuxdL~m0R7luiwnYBFRQh5mOmQDaT9oflSpHmXqik8et17HRIVFvwM~g~hnSD8arxzfTMGBhhqwz-IB0zKDKBKOqNy~h8Sn2~D4BVGGLsa7BzgakjvB8Zo-fRwYmrtxa-2cGTgEkeirG8tjVerjPjr4~J3hdNYK-MVxdYWg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":111412,"name":"TURKISH","url":"https://www.academia.edu/Documents/in/TURKISH"},{"id":199319,"name":"Citation","url":"https://www.academia.edu/Documents/in/Citation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539203"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539203/Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles"><img alt="Research paper thumbnail of Increased Susceptibility to Apoptosis and Growth Arrest of Human Breast Cancer Cells Treated by a Snake Venom-Loaded Silica Nanoparticles" class="work-thumbnail" src="https://attachments.academia-assets.com/93326282/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539203/Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles">Increased Susceptibility to Apoptosis and Growth Arrest of Human Breast Cancer Cells Treated by a Snake Venom-Loaded Silica Nanoparticles</a></div><div class="wp-workCard_item"><span>Cellular Physiology and Biochemistry</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (<a href="http://www.karger.com/OA-license" rel="nofollow">www.karger.com/OA-license</a>), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a4d22124c109a2cabbcb4296a9cab84d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326282,"asset_id":89539203,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326282/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539203"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539203"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539203; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539203]").text(description); $(".js-view-count[data-work-id=89539203]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539203; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539203']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539203, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a4d22124c109a2cabbcb4296a9cab84d" } } $('.js-work-strip[data-work-id=89539203]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539203,"title":"Increased Susceptibility to Apoptosis and Growth Arrest of Human Breast Cancer Cells Treated by a Snake Venom-Loaded Silica Nanoparticles","translated_title":"","metadata":{"publisher":"S. Karger AG","grobid_abstract":"This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Cellular Physiology and Biochemistry","grobid_abstract_attachment_id":93326282},"translated_abstract":null,"internal_url":"https://www.academia.edu/89539203/Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles","translated_internal_url":"","created_at":"2022-10-30T09:38:04.522-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326282,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326282/thumbnails/1.jpg","file_name":"366366.pdf","download_url":"https://www.academia.edu/attachments/93326282/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Increased_Susceptibility_to_Apoptosis_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326282/366366-libre.pdf?1667150948=\u0026response-content-disposition=attachment%3B+filename%3DIncreased_Susceptibility_to_Apoptosis_an.pdf\u0026Expires=1734541249\u0026Signature=Zy9EPJoZYhClLS~GteaW0L0fwmdyO~kUGtSwqunvA-EXFOckuESd1~R814Sz9S1nzT2yXHFEz0lsVTeuQTgjDoMsWyqlPlSde6Hgbu2hg9pcAncLA5XiWUaA72Dow37vh9EaAmagYLpp0PzzhWOZ0WHTuMXI3nKh1GmDYTl5RFaVBSr~r2rR0StZ2~tjwt5tfrXZFBpAk~C4N6HyLQ9ZRmKFINZfWDga7lHES79aBjAPUQz1F2d1aGmWNGuOQCavjQMOa~CVmS7fGvdmv7gGO6z-kjfR-yNlBcQA4XyN5kEFcB1~V6mwQxICC86y8faID3IF66fTWHMDGyO8sFHSCA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles","translated_slug":"","page_count":12,"language":"en","content_type":"Work","summary":"This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326282,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326282/thumbnails/1.jpg","file_name":"366366.pdf","download_url":"https://www.academia.edu/attachments/93326282/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Increased_Susceptibility_to_Apoptosis_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326282/366366-libre.pdf?1667150948=\u0026response-content-disposition=attachment%3B+filename%3DIncreased_Susceptibility_to_Apoptosis_an.pdf\u0026Expires=1734541249\u0026Signature=Zy9EPJoZYhClLS~GteaW0L0fwmdyO~kUGtSwqunvA-EXFOckuESd1~R814Sz9S1nzT2yXHFEz0lsVTeuQTgjDoMsWyqlPlSde6Hgbu2hg9pcAncLA5XiWUaA72Dow37vh9EaAmagYLpp0PzzhWOZ0WHTuMXI3nKh1GmDYTl5RFaVBSr~r2rR0StZ2~tjwt5tfrXZFBpAk~C4N6HyLQ9ZRmKFINZfWDga7lHES79aBjAPUQz1F2d1aGmWNGuOQCavjQMOa~CVmS7fGvdmv7gGO6z-kjfR-yNlBcQA4XyN5kEFcB1~V6mwQxICC86y8faID3IF66fTWHMDGyO8sFHSCA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer"},{"id":13621,"name":"Nanoparticles","url":"https://www.academia.edu/Documents/in/Nanoparticles"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":34713,"name":"Snake venoms","url":"https://www.academia.edu/Documents/in/Snake_venoms"},{"id":50841,"name":"Caspases","url":"https://www.academia.edu/Documents/in/Caspases"},{"id":82978,"name":"Reactive Oxygen Species","url":"https://www.academia.edu/Documents/in/Reactive_Oxygen_Species"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":506082,"name":"Cancer Cell","url":"https://www.academia.edu/Documents/in/Cancer_Cell"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":1031069,"name":"Silicon Dioxide","url":"https://www.academia.edu/Documents/in/Silicon_Dioxide"},{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms"}],"urls":[{"id":25314608,"url":"https://www.karger.com/Article/Pdf/366366"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539201"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539201/Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds"><img alt="Research paper thumbnail of Synthesis and Cytotoxicity of Novel 3-Aryl-1-(3′-dibenzylaminomethyl-4′-hydroxyphenyl)-propenones and Related Compounds" class="work-thumbnail" src="https://attachments.academia-assets.com/93326281/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539201/Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds">Synthesis and Cytotoxicity of Novel 3-Aryl-1-(3′-dibenzylaminomethyl-4′-hydroxyphenyl)-propenones and Related Compounds</a></div><div class="wp-workCard_item"><span>CHEMICAL &amp; PHARMACEUTICAL BULLETIN</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to the formation of a novel series of 4-hydroxy-3-dibenzylaminomethyl chalcones (7a-e) instead of 4-hydroxy-3,5bis-(dibenzylaminomethyl)chalcones 4. In order to rationalise the formation of monoadduct 7, energy minimized model structures of 4a and 7a were compared. The in vitro cytotoxic activities of 7a-e were tested against PC-3 cell lines for the first time in this study and compared with the precursor 4-hydroxychalcones (1a-e). Except for compound 7a (IC 50 : 19.85 m mM), insertion of dibenzylaminomethyl function into 4-hydroxychalcones resulted in complete loss of cytotoxic activity. The results suggested that it is not only the pK a but also the shape and size of the amine that is critical in governing the cytotoxic activity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="75424badaa3b833e31af9a2c27c178c5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326281,"asset_id":89539201,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326281/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539201"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539201"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539201; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539201]").text(description); $(".js-view-count[data-work-id=89539201]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539201; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539201']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539201, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "75424badaa3b833e31af9a2c27c178c5" } } $('.js-work-strip[data-work-id=89539201]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539201,"title":"Synthesis and Cytotoxicity of Novel 3-Aryl-1-(3′-dibenzylaminomethyl-4′-hydroxyphenyl)-propenones and Related Compounds","translated_title":"","metadata":{"publisher":"Pharmaceutical Society of Japan","grobid_abstract":"The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to the formation of a novel series of 4-hydroxy-3-dibenzylaminomethyl chalcones (7a-e) instead of 4-hydroxy-3,5bis-(dibenzylaminomethyl)chalcones 4. In order to rationalise the formation of monoadduct 7, energy minimized model structures of 4a and 7a were compared. The in vitro cytotoxic activities of 7a-e were tested against PC-3 cell lines for the first time in this study and compared with the precursor 4-hydroxychalcones (1a-e). Except for compound 7a (IC 50 : 19.85 m mM), insertion of dibenzylaminomethyl function into 4-hydroxychalcones resulted in complete loss of cytotoxic activity. The results suggested that it is not only the pK a but also the shape and size of the amine that is critical in governing the cytotoxic activity.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"CHEMICAL \u0026amp; PHARMACEUTICAL BULLETIN","grobid_abstract_attachment_id":93326281},"translated_abstract":null,"internal_url":"https://www.academia.edu/89539201/Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds","translated_internal_url":"","created_at":"2022-10-30T09:38:04.382-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326281,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326281/thumbnails/1.jpg","file_name":"_pdf.pdf","download_url":"https://www.academia.edu/attachments/93326281/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Synthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326281/_pdf-libre.pdf?1667150945=\u0026response-content-disposition=attachment%3B+filename%3DSynthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf\u0026Expires=1734541249\u0026Signature=GXxogGONHgEsqySftD7ejmX8gugbYqdJujb6Hx08UzBpFSvQ4FwtPhO5G8w5QHpkkF~aDUDymcxlfflgYGooCFEjqmP8meChQu86nVxUMsj2Hl3kl209U~aa7LaJzaENahnQBbRkuQrtschsMh3cuLHJnUg81TE21aBgKgazDo76fHDNl4ogIgH5bBAPzYbRX1vuz1cJNSp7LdaMtmCsQG~6qpIgP1cbNhUe~eHxT-P6HSeDA-TYB0PPXXFK9G9VfWbfXBDVVFngM8mnhApV2wykreV4wvptNvSUwRTGToT~GOV5x1XWhH6-SnqjEsfHsir4kvSOGiGAyRAOMsYIkg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds","translated_slug":"","page_count":7,"language":"en","content_type":"Work","summary":"The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to the formation of a novel series of 4-hydroxy-3-dibenzylaminomethyl chalcones (7a-e) instead of 4-hydroxy-3,5bis-(dibenzylaminomethyl)chalcones 4. In order to rationalise the formation of monoadduct 7, energy minimized model structures of 4a and 7a were compared. The in vitro cytotoxic activities of 7a-e were tested against PC-3 cell lines for the first time in this study and compared with the precursor 4-hydroxychalcones (1a-e). Except for compound 7a (IC 50 : 19.85 m mM), insertion of dibenzylaminomethyl function into 4-hydroxychalcones resulted in complete loss of cytotoxic activity. The results suggested that it is not only the pK a but also the shape and size of the amine that is critical in governing the cytotoxic activity.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326281,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326281/thumbnails/1.jpg","file_name":"_pdf.pdf","download_url":"https://www.academia.edu/attachments/93326281/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Synthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326281/_pdf-libre.pdf?1667150945=\u0026response-content-disposition=attachment%3B+filename%3DSynthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf\u0026Expires=1734541249\u0026Signature=GXxogGONHgEsqySftD7ejmX8gugbYqdJujb6Hx08UzBpFSvQ4FwtPhO5G8w5QHpkkF~aDUDymcxlfflgYGooCFEjqmP8meChQu86nVxUMsj2Hl3kl209U~aa7LaJzaENahnQBbRkuQrtschsMh3cuLHJnUg81TE21aBgKgazDo76fHDNl4ogIgH5bBAPzYbRX1vuz1cJNSp7LdaMtmCsQG~6qpIgP1cbNhUe~eHxT-P6HSeDA-TYB0PPXXFK9G9VfWbfXBDVVFngM8mnhApV2wykreV4wvptNvSUwRTGToT~GOV5x1XWhH6-SnqjEsfHsir4kvSOGiGAyRAOMsYIkg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":12597,"name":"Crystallization","url":"https://www.academia.edu/Documents/in/Crystallization"},{"id":14054,"name":"Chemical","url":"https://www.academia.edu/Documents/in/Chemical"},{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy"},{"id":22050,"name":"Cytotoxicity","url":"https://www.academia.edu/Documents/in/Cytotoxicity"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":114715,"name":"Stereochemistry","url":"https://www.academia.edu/Documents/in/Stereochemistry"},{"id":184989,"name":"Carcinogens","url":"https://www.academia.edu/Documents/in/Carcinogens"},{"id":309949,"name":"Propane","url":"https://www.academia.edu/Documents/in/Propane"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":1162913,"name":"Mutagens","url":"https://www.academia.edu/Documents/in/Mutagens"},{"id":1271583,"name":"Aryl","url":"https://www.academia.edu/Documents/in/Aryl"},{"id":2898895,"name":"binding sites","url":"https://www.academia.edu/Documents/in/binding_sites"},{"id":3024741,"name":"ketones","url":"https://www.academia.edu/Documents/in/ketones"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":25314606,"url":"https://www.jstage.jst.go.jp/article/cpb/56/12/56_12_1675/_pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3176611" id="papers"><div class="js-work-strip profile--work_container" data-work-id="115164667"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115164667/Sporti_f_Performans_%C4%B0%C3%A7i_n_Opti_mal_V%C3%BCcut_A%C4%9Firli%C4%9Fi"><img alt="Research paper thumbnail of Sporti̇f Performans İçi̇n Opti̇mal Vücut Ağirliği" class="work-thumbnail" src="https://attachments.academia-assets.com/111653223/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115164667/Sporti_f_Performans_%C4%B0%C3%A7i_n_Opti_mal_V%C3%BCcut_A%C4%9Firli%C4%9Fi">Sporti̇f Performans İçi̇n Opti̇mal Vücut Ağirliği</a></div><div class="wp-workCard_item"><span>Journal of Physical Education and Sport Sciences</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6c846dd204ea9693a9567ca5496ba960" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111653223,"asset_id":115164667,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111653223/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115164667"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115164667"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115164667; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115164667]").text(description); $(".js-view-count[data-work-id=115164667]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115164667; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115164667']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115164667, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6c846dd204ea9693a9567ca5496ba960" } } $('.js-work-strip[data-work-id=115164667]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115164667,"title":"Sporti̇f Performans İçi̇n Opti̇mal Vücut Ağirliği","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Journal of Physical Education and Sport Sciences"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115164667/Sporti_f_Performans_%C4%B0%C3%A7i_n_Opti_mal_V%C3%BCcut_A%C4%9Firli%C4%9Fi","translated_internal_url":"","created_at":"2024-02-20T05:01:26.718-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":111653223,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111653223/thumbnails/1.jpg","file_name":"297272.pdf","download_url":"https://www.academia.edu/attachments/111653223/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Sporti_f_Performans_Ici_n_Opti_mal_Vucut.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111653223/297272-libre.pdf?1708438141=\u0026response-content-disposition=attachment%3B+filename%3DSporti_f_Performans_Ici_n_Opti_mal_Vucut.pdf\u0026Expires=1734541248\u0026Signature=IUpEcOiTQDePAP0dA7~2DOshG96B2woOqLqb-TLzGaYMPBcOpT1jPArXln8YkfsqCjL-U3jn5htU3blsi3kefM754e5FfGPj2xYJVsQ0TNcmoMFVCchGE051UrF9oARZhuIXkLG3oBlPkHZLmdyvZ7QvoF2GyRH5SU3dNGGDXkbq7qC7IL6w6l8QHeGEP5GX4JY1rLsgPmhGsc3gWWZQmp1AMrMhWdMH6x9PUD9Cgyw7gBjduJzMLQ0T3IurrKt7mFzJ~e9bPBWwqoFndvoJF1dn8pKrDSTUN0UoyFvcKxEQE5A01kDDOliQQHIgVStSCJDdpbfaaaAMge5aHDi5GA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Sporti_f_Performans_İçi_n_Opti_mal_Vücut_Ağirliği","translated_slug":"","page_count":4,"language":"tr","content_type":"Work","summary":null,"owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":111653223,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111653223/thumbnails/1.jpg","file_name":"297272.pdf","download_url":"https://www.academia.edu/attachments/111653223/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Sporti_f_Performans_Ici_n_Opti_mal_Vucut.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111653223/297272-libre.pdf?1708438141=\u0026response-content-disposition=attachment%3B+filename%3DSporti_f_Performans_Ici_n_Opti_mal_Vucut.pdf\u0026Expires=1734541248\u0026Signature=IUpEcOiTQDePAP0dA7~2DOshG96B2woOqLqb-TLzGaYMPBcOpT1jPArXln8YkfsqCjL-U3jn5htU3blsi3kefM754e5FfGPj2xYJVsQ0TNcmoMFVCchGE051UrF9oARZhuIXkLG3oBlPkHZLmdyvZ7QvoF2GyRH5SU3dNGGDXkbq7qC7IL6w6l8QHeGEP5GX4JY1rLsgPmhGsc3gWWZQmp1AMrMhWdMH6x9PUD9Cgyw7gBjduJzMLQ0T3IurrKt7mFzJ~e9bPBWwqoFndvoJF1dn8pKrDSTUN0UoyFvcKxEQE5A01kDDOliQQHIgVStSCJDdpbfaaaAMge5aHDi5GA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":39633504,"url":"http://e-dergi.atauni.edu.tr/ataunibesyo/article/download/1025000782/1025000754"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110470283"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110470283/Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction"><img alt="Research paper thumbnail of Investigation of Serum NO, ADMA and Apelin Levels in Thyroid Dysfunction" class="work-thumbnail" src="https://attachments.academia-assets.com/108277733/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110470283/Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction">Investigation of Serum NO, ADMA and Apelin Levels in Thyroid Dysfunction</a></div><div class="wp-workCard_item"><span>Journal of Medicine, Physiology and Biophysics</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Thyroid gland diseases are among the most common endocrine diseases and still continue to be an i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Thyroid gland diseases are among the most common endocrine diseases and still continue to be an important health problem especially in developing countries. It was aimed to investigate serum NO, ADMA and Apelin levels in patients with thyroid dysfunction. This study was conducted with 150 thyroid patients and 50 healthy subjects. Study subjects were divided into three groups; control (n=50), hyperthyroid (n=75) and hypothyroid (n=75). Serum TSH, FT3, FT4 levels were measured by chemiluminescence method NO level were measured by spectrophotometric method, ADMA and apelin levels were measured by ELISA. Serum NO levels were higher in hypothyroid group than in hyperthyroid group, and the difference was statistically significant. Serum ADMA levels of the hyperthyroid group were significantly higher than the other two groups and the difference was statistically significant. The levels of serum apelin were statistically significantly higher in the hyperthyroid group than the other two groups. In patients with hyperthyroidism, ADMA and Apelin levels were higher, while NO level was lower. However, NO level was higher in patients with hypothyroidims than the other two groups. Apelin, which has been emphasized as a preventive and therapeutic agent particularly for the cardiovascular system, might have increased in hyperthyroid patients, regardless of NO, to protect cardiovascular system from possible adverse effects of ADMA.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1565e3921813a81977b23da4929582bd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108277733,"asset_id":110470283,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108277733/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110470283"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110470283"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110470283; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110470283]").text(description); $(".js-view-count[data-work-id=110470283]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110470283; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110470283']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110470283, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1565e3921813a81977b23da4929582bd" } } $('.js-work-strip[data-work-id=110470283]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110470283,"title":"Investigation of Serum NO, ADMA and Apelin Levels in Thyroid Dysfunction","translated_title":"","metadata":{"publisher":"International Institute for Science, Technology and Education","grobid_abstract":"Thyroid gland diseases are among the most common endocrine diseases and still continue to be an important health problem especially in developing countries. It was aimed to investigate serum NO, ADMA and Apelin levels in patients with thyroid dysfunction. This study was conducted with 150 thyroid patients and 50 healthy subjects. Study subjects were divided into three groups; control (n=50), hyperthyroid (n=75) and hypothyroid (n=75). Serum TSH, FT3, FT4 levels were measured by chemiluminescence method NO level were measured by spectrophotometric method, ADMA and apelin levels were measured by ELISA. Serum NO levels were higher in hypothyroid group than in hyperthyroid group, and the difference was statistically significant. Serum ADMA levels of the hyperthyroid group were significantly higher than the other two groups and the difference was statistically significant. The levels of serum apelin were statistically significantly higher in the hyperthyroid group than the other two groups. In patients with hyperthyroidism, ADMA and Apelin levels were higher, while NO level was lower. However, NO level was higher in patients with hypothyroidims than the other two groups. Apelin, which has been emphasized as a preventive and therapeutic agent particularly for the cardiovascular system, might have increased in hyperthyroid patients, regardless of NO, to protect cardiovascular system from possible adverse effects of ADMA.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Journal of Medicine, Physiology and Biophysics","grobid_abstract_attachment_id":108277733},"translated_abstract":null,"internal_url":"https://www.academia.edu/110470283/Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction","translated_internal_url":"","created_at":"2023-12-03T12:58:01.826-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":108277733,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108277733/thumbnails/1.jpg","file_name":"Sahin_et_al._Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction_2020.pdf","download_url":"https://www.academia.edu/attachments/108277733/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Investigation_of_Serum_NO_ADMA_and_Apeli.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108277733/Sahin_et_al._Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction_2020-libre.pdf?1701638128=\u0026response-content-disposition=attachment%3B+filename%3DInvestigation_of_Serum_NO_ADMA_and_Apeli.pdf\u0026Expires=1734541248\u0026Signature=V2xC-jN91tWpKiVQV1eE4K7Cy50OF3empgxUtThINqFUC-Hc~OXc-fgmLNZW6PJu7o1YKonzQP5q3V7LuO5uLNIll87VteVgzniv62amkZJ3HD7~zx8hDYlXVo-lIzuZWyb1SKHNSY4uqKuseoDBHomCdhQTrTATVZA-lzMXZ1cVZ9VUWkUxsFQo-uIRr73aolM198zABqyM6IJcjXWIdjtt-wA8D2YFlNhhW~vFrGGbSit4-v8FMiGY09Iq~X~3Dzcp1ozi3HmvlUYM1pA~ZSW0K3fbDIuAz~jL5vDnvvl6hG1Qo~Ps2xdWK1sY1mrGFxgAFFg5soN1pEs03FqGjQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction","translated_slug":"","page_count":7,"language":"en","content_type":"Work","summary":"Thyroid gland diseases are among the most common endocrine diseases and still continue to be an important health problem especially in developing countries. It was aimed to investigate serum NO, ADMA and Apelin levels in patients with thyroid dysfunction. This study was conducted with 150 thyroid patients and 50 healthy subjects. Study subjects were divided into three groups; control (n=50), hyperthyroid (n=75) and hypothyroid (n=75). Serum TSH, FT3, FT4 levels were measured by chemiluminescence method NO level were measured by spectrophotometric method, ADMA and apelin levels were measured by ELISA. Serum NO levels were higher in hypothyroid group than in hyperthyroid group, and the difference was statistically significant. Serum ADMA levels of the hyperthyroid group were significantly higher than the other two groups and the difference was statistically significant. The levels of serum apelin were statistically significantly higher in the hyperthyroid group than the other two groups. In patients with hyperthyroidism, ADMA and Apelin levels were higher, while NO level was lower. However, NO level was higher in patients with hypothyroidims than the other two groups. Apelin, which has been emphasized as a preventive and therapeutic agent particularly for the cardiovascular system, might have increased in hyperthyroid patients, regardless of NO, to protect cardiovascular system from possible adverse effects of ADMA.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":108277733,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108277733/thumbnails/1.jpg","file_name":"Sahin_et_al._Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction_2020.pdf","download_url":"https://www.academia.edu/attachments/108277733/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Investigation_of_Serum_NO_ADMA_and_Apeli.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108277733/Sahin_et_al._Investigation_of_Serum_NO_ADMA_and_Apelin_Levels_in_Thyroid_Dysfunction_2020-libre.pdf?1701638128=\u0026response-content-disposition=attachment%3B+filename%3DInvestigation_of_Serum_NO_ADMA_and_Apeli.pdf\u0026Expires=1734541248\u0026Signature=V2xC-jN91tWpKiVQV1eE4K7Cy50OF3empgxUtThINqFUC-Hc~OXc-fgmLNZW6PJu7o1YKonzQP5q3V7LuO5uLNIll87VteVgzniv62amkZJ3HD7~zx8hDYlXVo-lIzuZWyb1SKHNSY4uqKuseoDBHomCdhQTrTATVZA-lzMXZ1cVZ9VUWkUxsFQo-uIRr73aolM198zABqyM6IJcjXWIdjtt-wA8D2YFlNhhW~vFrGGbSit4-v8FMiGY09Iq~X~3Dzcp1ozi3HmvlUYM1pA~ZSW0K3fbDIuAz~jL5vDnvvl6hG1Qo~Ps2xdWK1sY1mrGFxgAFFg5soN1pEs03FqGjQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":30649,"name":"Thyroid","url":"https://www.academia.edu/Documents/in/Thyroid"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":976254,"name":"Serum Asymmetric Dimethylarginine (ADMA)","url":"https://www.academia.edu/Documents/in/Serum_Asymmetric_Dimethylarginine_ADMA_"},{"id":1139929,"name":"Apelin","url":"https://www.academia.edu/Documents/in/Apelin"},{"id":1641959,"name":"Thyroid Dysfunction","url":"https://www.academia.edu/Documents/in/Thyroid_Dysfunction"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110469999"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110469999/Hippophae_rhamnoides_attenuates_nicotine_induced_oxidative_stress_in_rat_liver"><img alt="Research paper thumbnail of Hippophae rhamnoides attenuates nicotine-induced oxidative stress in rat liver" class="work-thumbnail" src="https://attachments.academia-assets.com/108366128/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110469999/Hippophae_rhamnoides_attenuates_nicotine_induced_oxidative_stress_in_rat_liver">Hippophae rhamnoides attenuates nicotine-induced oxidative stress in rat liver</a></div><div class="wp-workCard_item"><span>Pharmaceutical Biology</span><span>, Apr 19, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The effects of vitamin E and Hippophae rhamnoides L. (Elaeagnaceae) extract (HRe-1) on nicotine-i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The effects of vitamin E and Hippophae rhamnoides L. (Elaeagnaceae) extract (HRe-1) on nicotine-induced oxidative stress in rat liver were investigated. Four groups, eight rats each, were used in this study, and the supplementation period was 3 weeks. The groups were: nicotine (0.5 mg/kg/day, intraperitoneal (i.p.)); nicotine plus vitamin E (75 mg/kg/day, intragastric (i.g.)); nicotine plus HRe-1 (250 mg/kg/day, i.g.); and the control group. The malondialdehyde and nitric oxide levels, glutathione peroxidase, glutathione S-transferase, glutathione reductase, superoxide dismutase, and total and non-enzymatic superoxide scavenger activities were measured spectrophotometrically in supernatants of the tissue homogenates. Nicotine increased the malondialdehyde level in liver tissue compared with control. This nicotine-induced increase in lipid peroxidation was prevented by both vitamin E and HRe-1. Superoxide dismutase activity was higher in the nicotine plus vitamin E-supplemented group compared with nicotine and control groups. Glutathione reductase activity was higher in the nicotine group compared with the control group. However, glutathione peroxidase activity in the control group was higher than the levels in the nicotine, and the nicotine plus HRe-1 supplemented groups. The nitric oxide level was higher in the nicotine group compared with all other groups. Total and non-enzymatic superoxide scavenger activities and glutathione S-transferase activity were not affected by any of the treatments. Our results suggest that Hippophae rhamnoides extract as well as vitamin E can protect the liver against nicotine-induced oxidative stress.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="49a3267eecd6f89942ab071fe91b7b1b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108366128,"asset_id":110469999,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108366128/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110469999"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110469999"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110469999; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110469999]").text(description); $(".js-view-count[data-work-id=110469999]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110469999; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110469999']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110469999, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "49a3267eecd6f89942ab071fe91b7b1b" } } $('.js-work-strip[data-work-id=110469999]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110469999,"title":"Hippophae rhamnoides attenuates nicotine-induced oxidative stress in rat liver","translated_title":"","metadata":{"abstract":"The effects of vitamin E and Hippophae rhamnoides L. (Elaeagnaceae) extract (HRe-1) on nicotine-induced oxidative stress in rat liver were investigated. Four groups, eight rats each, were used in this study, and the supplementation period was 3 weeks. The groups were: nicotine (0.5 mg/kg/day, intraperitoneal (i.p.)); nicotine plus vitamin E (75 mg/kg/day, intragastric (i.g.)); nicotine plus HRe-1 (250 mg/kg/day, i.g.); and the control group. The malondialdehyde and nitric oxide levels, glutathione peroxidase, glutathione S-transferase, glutathione reductase, superoxide dismutase, and total and non-enzymatic superoxide scavenger activities were measured spectrophotometrically in supernatants of the tissue homogenates. Nicotine increased the malondialdehyde level in liver tissue compared with control. This nicotine-induced increase in lipid peroxidation was prevented by both vitamin E and HRe-1. Superoxide dismutase activity was higher in the nicotine plus vitamin E-supplemented group compared with nicotine and control groups. Glutathione reductase activity was higher in the nicotine group compared with the control group. However, glutathione peroxidase activity in the control group was higher than the levels in the nicotine, and the nicotine plus HRe-1 supplemented groups. The nitric oxide level was higher in the nicotine group compared with all other groups. Total and non-enzymatic superoxide scavenger activities and glutathione S-transferase activity were not affected by any of the treatments. Our results suggest that Hippophae rhamnoides extract as well as vitamin E can protect the liver against nicotine-induced oxidative stress.","publisher":"Taylor \u0026 Francis","publication_date":{"day":19,"month":4,"year":2010,"errors":{}},"publication_name":"Pharmaceutical Biology"},"translated_abstract":"The effects of vitamin E and Hippophae rhamnoides L. (Elaeagnaceae) extract (HRe-1) on nicotine-induced oxidative stress in rat liver were investigated. Four groups, eight rats each, were used in this study, and the supplementation period was 3 weeks. The groups were: nicotine (0.5 mg/kg/day, intraperitoneal (i.p.)); nicotine plus vitamin E (75 mg/kg/day, intragastric (i.g.)); nicotine plus HRe-1 (250 mg/kg/day, i.g.); and the control group. The malondialdehyde and nitric oxide levels, glutathione peroxidase, glutathione S-transferase, glutathione reductase, superoxide dismutase, and total and non-enzymatic superoxide scavenger activities were measured spectrophotometrically in supernatants of the tissue homogenates. Nicotine increased the malondialdehyde level in liver tissue compared with control. This nicotine-induced increase in lipid peroxidation was prevented by both vitamin E and HRe-1. Superoxide dismutase activity was higher in the nicotine plus vitamin E-supplemented group compared with nicotine and control groups. Glutathione reductase activity was higher in the nicotine group compared with the control group. However, glutathione peroxidase activity in the control group was higher than the levels in the nicotine, and the nicotine plus HRe-1 supplemented groups. The nitric oxide level was higher in the nicotine group compared with all other groups. Total and non-enzymatic superoxide scavenger activities and glutathione S-transferase activity were not affected by any of the treatments. Our results suggest that Hippophae rhamnoides extract as well as vitamin E can protect the liver against nicotine-induced oxidative stress.","internal_url":"https://www.academia.edu/110469999/Hippophae_rhamnoides_attenuates_nicotine_induced_oxidative_stress_in_rat_liver","translated_internal_url":"","created_at":"2023-12-03T12:54:28.120-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":108366128,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108366128/thumbnails/1.jpg","file_name":"Taysi_et_al._Pharmaceutical_Biology_2010.pdf","download_url":"https://www.academia.edu/attachments/108366128/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Hippophae_rhamnoides_attenuates_nicotine.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108366128/Taysi_et_al._Pharmaceutical_Biology_2010-libre.pdf?1701759641=\u0026response-content-disposition=attachment%3B+filename%3DHippophae_rhamnoides_attenuates_nicotine.pdf\u0026Expires=1734541248\u0026Signature=Ebg5zYALaEL~Fqa10qPZKfcOWdqX9wlBbRl5ElCLJXZXewidXmdt2u-ntZx8EfGnzdYzRqJy5mJxCGXmT663Od7z1JV5MuAIBzZzLR1zKRM37FC0c-KepEYOGWCjy17ljCc9cgXGmor6Ua3IONHatW6qmlOfmTJipGNI7f4MThuqpmin1~MZvMAmNZ3FrL97TqkvF8pBPt0Mvcv6~8sh6JYCMYX9y8TrLCAv9RkajB-Fgyrc5RJe9Cv5bCK3JRDHzqmB974ADu7sBSU2tU5aPi1kuXAevZ1WzUNjSOLcbQf64N2~c4htJhQdpVVTE22l~kVhCLWdXxRrNqYIp6-xVQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Hippophae_rhamnoides_attenuates_nicotine_induced_oxidative_stress_in_rat_liver","translated_slug":"","page_count":6,"language":"en","content_type":"Work","summary":"The effects of vitamin E and Hippophae rhamnoides L. (Elaeagnaceae) extract (HRe-1) on nicotine-induced oxidative stress in rat liver were investigated. Four groups, eight rats each, were used in this study, and the supplementation period was 3 weeks. The groups were: nicotine (0.5 mg/kg/day, intraperitoneal (i.p.)); nicotine plus vitamin E (75 mg/kg/day, intragastric (i.g.)); nicotine plus HRe-1 (250 mg/kg/day, i.g.); and the control group. The malondialdehyde and nitric oxide levels, glutathione peroxidase, glutathione S-transferase, glutathione reductase, superoxide dismutase, and total and non-enzymatic superoxide scavenger activities were measured spectrophotometrically in supernatants of the tissue homogenates. Nicotine increased the malondialdehyde level in liver tissue compared with control. This nicotine-induced increase in lipid peroxidation was prevented by both vitamin E and HRe-1. Superoxide dismutase activity was higher in the nicotine plus vitamin E-supplemented group compared with nicotine and control groups. Glutathione reductase activity was higher in the nicotine group compared with the control group. However, glutathione peroxidase activity in the control group was higher than the levels in the nicotine, and the nicotine plus HRe-1 supplemented groups. The nitric oxide level was higher in the nicotine group compared with all other groups. Total and non-enzymatic superoxide scavenger activities and glutathione S-transferase activity were not affected by any of the treatments. Our results suggest that Hippophae rhamnoides extract as well as vitamin E can protect the liver against nicotine-induced oxidative stress.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":108366128,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108366128/thumbnails/1.jpg","file_name":"Taysi_et_al._Pharmaceutical_Biology_2010.pdf","download_url":"https://www.academia.edu/attachments/108366128/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Hippophae_rhamnoides_attenuates_nicotine.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108366128/Taysi_et_al._Pharmaceutical_Biology_2010-libre.pdf?1701759641=\u0026response-content-disposition=attachment%3B+filename%3DHippophae_rhamnoides_attenuates_nicotine.pdf\u0026Expires=1734541248\u0026Signature=Ebg5zYALaEL~Fqa10qPZKfcOWdqX9wlBbRl5ElCLJXZXewidXmdt2u-ntZx8EfGnzdYzRqJy5mJxCGXmT663Od7z1JV5MuAIBzZzLR1zKRM37FC0c-KepEYOGWCjy17ljCc9cgXGmor6Ua3IONHatW6qmlOfmTJipGNI7f4MThuqpmin1~MZvMAmNZ3FrL97TqkvF8pBPt0Mvcv6~8sh6JYCMYX9y8TrLCAv9RkajB-Fgyrc5RJe9Cv5bCK3JRDHzqmB974ADu7sBSU2tU5aPi1kuXAevZ1WzUNjSOLcbQf64N2~c4htJhQdpVVTE22l~kVhCLWdXxRrNqYIp6-xVQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver"},{"id":91360,"name":"Nicotine","url":"https://www.academia.edu/Documents/in/Nicotine"},{"id":95655,"name":"Pharmaceutical","url":"https://www.academia.edu/Documents/in/Pharmaceutical"},{"id":118450,"name":"Glutathione","url":"https://www.academia.edu/Documents/in/Glutathione"},{"id":141395,"name":"Glutathione Peroxidase","url":"https://www.academia.edu/Documents/in/Glutathione_Peroxidase"},{"id":160814,"name":"Fruit","url":"https://www.academia.edu/Documents/in/Fruit"},{"id":233372,"name":"Lipid peroxidation","url":"https://www.academia.edu/Documents/in/Lipid_peroxidation"},{"id":308667,"name":"Pharmaceutical Biology","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Biology"},{"id":354056,"name":"Plant extracts","url":"https://www.academia.edu/Documents/in/Plant_extracts"},{"id":1011463,"name":"Glutathione Reductase","url":"https://www.academia.edu/Documents/in/Glutathione_Reductase"},{"id":1108282,"name":"Hippophae","url":"https://www.academia.edu/Documents/in/Hippophae"},{"id":1446339,"name":"Malondialdehyde","url":"https://www.academia.edu/Documents/in/Malondialdehyde"},{"id":2463495,"name":"Random Allocation","url":"https://www.academia.edu/Documents/in/Random_Allocation"},{"id":3194331,"name":"Rat Liver","url":"https://www.academia.edu/Documents/in/Rat_Liver"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":36368365,"url":"https://doi.org/10.3109/13880200903179707"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105228595"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105228595/Effects_of_endurance_training_on_tissue_glutathione_homeostasis_and_lipid_peroxidation_in_streptozotocin_induced_diabetic_rats"><img alt="Research paper thumbnail of Effects of endurance training on tissue glutathione homeostasis and lipid peroxidation in streptozotocin-induced diabetic rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105228595/Effects_of_endurance_training_on_tissue_glutathione_homeostasis_and_lipid_peroxidation_in_streptozotocin_induced_diabetic_rats">Effects of endurance training on tissue glutathione homeostasis and lipid peroxidation in streptozotocin-induced diabetic rats</a></div><div class="wp-workCard_item"><span>Scandinavian Journal of Medicine &amp; Science in Sports</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aims of our study were to assess whether endurance training strengthens glutathione-dependent...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aims of our study were to assess whether endurance training strengthens glutathione-dependent antioxidant defenses and decreases oxidative stress in experimental diabetes. Streptozotocin-induced diabetic rats were divided into trained and untrained groups, which were further divided into resting and acute exercise groups. Endurance training consisted of treadmill running for 8 weeks. For acute exhaustive exercise, graded treadmill running was conducted until exhaustion. Eight weeks&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; treadmill training increased the endurance, favorably decreased lipid peroxidation as measured by thiobarbituric acid reactive substances but not conjugated dienes levels in kidney and vastus lateralis muscle and upregulated glutathione peroxidase in red gastrocnemius muscle. However, it adversely decreased total glutathione level and glutathione peroxidase activity in kidney. Acute exhaustive exercise up-regulated glutathione peroxidase activity in liver. Endurance training did not prevent the increase in thiobarbituric acid reactive substances level in liver due to acute exhaustive exercise. Activities of glutathione disulfide reductase and glutathione S-transferase were not affected. Even though endurance training appeared to upregulate glutathione dependent antioxidant defense in skeletal muscle and to decrease lipid peroxidation in kidney and vastus lateralis muscle as measured by TBARS, our results suggests that beneficial effects of 8 weeks of endurance training are limited in this rat model of uncontrolled diabetes mellitus.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105228595"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105228595"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105228595; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105228595]").text(description); $(".js-view-count[data-work-id=105228595]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105228595; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105228595']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105228595, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105228595]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105228595,"title":"Effects of endurance training on tissue glutathione homeostasis and lipid peroxidation in streptozotocin-induced diabetic rats","translated_title":"","metadata":{"abstract":"The aims of our study were to assess whether endurance training strengthens glutathione-dependent antioxidant defenses and decreases oxidative stress in experimental diabetes. Streptozotocin-induced diabetic rats were divided into trained and untrained groups, which were further divided into resting and acute exercise groups. Endurance training consisted of treadmill running for 8 weeks. For acute exhaustive exercise, graded treadmill running was conducted until exhaustion. Eight weeks\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; treadmill training increased the endurance, favorably decreased lipid peroxidation as measured by thiobarbituric acid reactive substances but not conjugated dienes levels in kidney and vastus lateralis muscle and upregulated glutathione peroxidase in red gastrocnemius muscle. However, it adversely decreased total glutathione level and glutathione peroxidase activity in kidney. Acute exhaustive exercise up-regulated glutathione peroxidase activity in liver. Endurance training did not prevent the increase in thiobarbituric acid reactive substances level in liver due to acute exhaustive exercise. Activities of glutathione disulfide reductase and glutathione S-transferase were not affected. Even though endurance training appeared to upregulate glutathione dependent antioxidant defense in skeletal muscle and to decrease lipid peroxidation in kidney and vastus lateralis muscle as measured by TBARS, our results suggests that beneficial effects of 8 weeks of endurance training are limited in this rat model of uncontrolled diabetes mellitus.","publisher":"Wiley","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Scandinavian Journal of Medicine \u0026amp; Science in Sports"},"translated_abstract":"The aims of our study were to assess whether endurance training strengthens glutathione-dependent antioxidant defenses and decreases oxidative stress in experimental diabetes. Streptozotocin-induced diabetic rats were divided into trained and untrained groups, which were further divided into resting and acute exercise groups. Endurance training consisted of treadmill running for 8 weeks. For acute exhaustive exercise, graded treadmill running was conducted until exhaustion. Eight weeks\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; treadmill training increased the endurance, favorably decreased lipid peroxidation as measured by thiobarbituric acid reactive substances but not conjugated dienes levels in kidney and vastus lateralis muscle and upregulated glutathione peroxidase in red gastrocnemius muscle. However, it adversely decreased total glutathione level and glutathione peroxidase activity in kidney. Acute exhaustive exercise up-regulated glutathione peroxidase activity in liver. Endurance training did not prevent the increase in thiobarbituric acid reactive substances level in liver due to acute exhaustive exercise. Activities of glutathione disulfide reductase and glutathione S-transferase were not affected. Even though endurance training appeared to upregulate glutathione dependent antioxidant defense in skeletal muscle and to decrease lipid peroxidation in kidney and vastus lateralis muscle as measured by TBARS, our results suggests that beneficial effects of 8 weeks of endurance training are limited in this rat model of uncontrolled diabetes mellitus.","internal_url":"https://www.academia.edu/105228595/Effects_of_endurance_training_on_tissue_glutathione_homeostasis_and_lipid_peroxidation_in_streptozotocin_induced_diabetic_rats","translated_internal_url":"","created_at":"2023-08-03T13:23:05.650-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effects_of_endurance_training_on_tissue_glutathione_homeostasis_and_lipid_peroxidation_in_streptozotocin_induced_diabetic_rats","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The aims of our study were to assess whether endurance training strengthens glutathione-dependent antioxidant defenses and decreases oxidative stress in experimental diabetes. Streptozotocin-induced diabetic rats were divided into trained and untrained groups, which were further divided into resting and acute exercise groups. Endurance training consisted of treadmill running for 8 weeks. For acute exhaustive exercise, graded treadmill running was conducted until exhaustion. Eight weeks\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; treadmill training increased the endurance, favorably decreased lipid peroxidation as measured by thiobarbituric acid reactive substances but not conjugated dienes levels in kidney and vastus lateralis muscle and upregulated glutathione peroxidase in red gastrocnemius muscle. However, it adversely decreased total glutathione level and glutathione peroxidase activity in kidney. Acute exhaustive exercise up-regulated glutathione peroxidase activity in liver. Endurance training did not prevent the increase in thiobarbituric acid reactive substances level in liver due to acute exhaustive exercise. Activities of glutathione disulfide reductase and glutathione S-transferase were not affected. Even though endurance training appeared to upregulate glutathione dependent antioxidant defense in skeletal muscle and to decrease lipid peroxidation in kidney and vastus lateralis muscle as measured by TBARS, our results suggests that beneficial effects of 8 weeks of endurance training are limited in this rat model of uncontrolled diabetes mellitus.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":4228,"name":"Skeletal muscle biology","url":"https://www.academia.edu/Documents/in/Skeletal_muscle_biology"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver"},{"id":103339,"name":"Antioxidant","url":"https://www.academia.edu/Documents/in/Antioxidant"},{"id":118450,"name":"Glutathione","url":"https://www.academia.edu/Documents/in/Glutathione"},{"id":141395,"name":"Glutathione Peroxidase","url":"https://www.academia.edu/Documents/in/Glutathione_Peroxidase"},{"id":233372,"name":"Lipid peroxidation","url":"https://www.academia.edu/Documents/in/Lipid_peroxidation"},{"id":357849,"name":"Skeletal Muscle","url":"https://www.academia.edu/Documents/in/Skeletal_Muscle"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":379889,"name":"Homeostasis","url":"https://www.academia.edu/Documents/in/Homeostasis"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance"},{"id":846529,"name":"Endurance Training","url":"https://www.academia.edu/Documents/in/Endurance_Training"},{"id":1011463,"name":"Glutathione Reductase","url":"https://www.academia.edu/Documents/in/Glutathione_Reductase"},{"id":1031967,"name":"Diabetic Rat","url":"https://www.academia.edu/Documents/in/Diabetic_Rat"}],"urls":[{"id":33230813,"url":"http://onlinelibrary.wiley.com/wol1/doi/10.1034/j.1600-0838.2002.120307.x/fullpdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105228594"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105228594/_Lipoic_Acid_Supplementation_in_Exercise"><img alt="Research paper thumbnail of ??-Lipoic Acid Supplementation in Exercise" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105228594/_Lipoic_Acid_Supplementation_in_Exercise">??-Lipoic Acid Supplementation in Exercise</a></div><div class="wp-workCard_item"><span>Medicine & Science in Sports & Exercise</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105228594"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105228594"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105228594; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105228594]").text(description); $(".js-view-count[data-work-id=105228594]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105228594; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105228594']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105228594, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105228594]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105228594,"title":"??-Lipoic Acid Supplementation in Exercise","translated_title":"","metadata":{"publisher":"Ovid Technologies (Wolters Kluwer Health)","publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Medicine \u0026 Science in Sports \u0026 Exercise"},"translated_abstract":null,"internal_url":"https://www.academia.edu/105228594/_Lipoic_Acid_Supplementation_in_Exercise","translated_internal_url":"","created_at":"2023-08-03T13:23:05.500-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_Lipoic_Acid_Supplementation_in_Exercise","translated_slug":"","page_count":null,"language":"fr","content_type":"Work","summary":null,"owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":424010,"name":"Alpha Lipoic Acid","url":"https://www.academia.edu/Documents/in/Alpha_Lipoic_Acid"},{"id":992395,"name":"Medicine and Science In Sports and Exercise","url":"https://www.academia.edu/Documents/in/Medicine_and_Science_In_Sports_and_Exercise"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="105228586"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/105228586/Skeletal_muscle_vitamin_E_and_ubiquinone_9_responses_to_training_and_lipoate_supplementation"><img alt="Research paper thumbnail of Skeletal muscle vitamin E and ubiquinone 9 responses to training and lipoate supplementation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/105228586/Skeletal_muscle_vitamin_E_and_ubiquinone_9_responses_to_training_and_lipoate_supplementation">Skeletal muscle vitamin E and ubiquinone 9 responses to training and lipoate supplementation</a></div><div class="wp-workCard_item"><span>Free Radical Biology and Medicine</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="105228586"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="105228586"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105228586; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105228586]").text(description); $(".js-view-count[data-work-id=105228586]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 105228586; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='105228586']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 105228586, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=105228586]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":105228586,"title":"Skeletal muscle vitamin E and ubiquinone 9 responses to training and lipoate supplementation","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Free Radical Biology and Medicine"},"translated_abstract":null,"internal_url":"https://www.academia.edu/105228586/Skeletal_muscle_vitamin_E_and_ubiquinone_9_responses_to_training_and_lipoate_supplementation","translated_internal_url":"","created_at":"2023-08-03T13:22:04.249-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Skeletal_muscle_vitamin_E_and_ubiquinone_9_responses_to_training_and_lipoate_supplementation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":null,"owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[],"research_interests":[{"id":259090,"name":"Oxidative stress and free radical biology and medicine","url":"https://www.academia.edu/Documents/in/Oxidative_stress_and_free_radical_biology_and_medicine"},{"id":357849,"name":"Skeletal Muscle","url":"https://www.academia.edu/Documents/in/Skeletal_Muscle"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4856708"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4856708/Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat"><img alt="Research paper thumbnail of Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat" class="work-thumbnail" src="https://attachments.academia-assets.com/49596184/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4856708/Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat">Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://griffith.academia.edu/LenaVider">Lena Vider</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://atauni.academia.edu/MustafaGul">Mustafa Gul</a></span></div><div class="wp-workCard_item"><span>Pathophysiology</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Oxygen free radicals are highly reactive species that can cause a wide spectrum of cell damage in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Oxygen free radicals are highly reactive species that can cause a wide spectrum of cell damage including lipid peroxidation, enzymes inactivation and DNA damage. Strenuous physical exercise has been shown to impose an oxidative stress on the body due to oxygen free radical generation including an increase in lipid peroxidation. These facts pertain especially to acute or unaccustomed exercise. The purpose of the present study was to examine the effect of the acute swimming exercise on lipid peroxidation. Studies were performed on 20 adult male Swiss albino rats. Animals were divided into 2 groups, 10 rats control group and 9 similar rats exercise group. After exercise blood was taken to measure erythrocyte MDA and haemoglobin levels. Results were expressed as nmol MDAigr Hb. MDA levels from exercise group were not significantly different from control group, with values of 27.4k9.2 and 255.t7.3 nmol MDA/gr Hb respectively (P>O.O5). We concluded that 1 hour swimming exercise doesn't increase lipid peroxidation in erythrocyte.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9f21a5e7284e25b3422de90d760c0d90" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49596184,"asset_id":4856708,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49596184/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4856708"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4856708"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4856708; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4856708]").text(description); $(".js-view-count[data-work-id=4856708]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4856708; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4856708']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 4856708, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9f21a5e7284e25b3422de90d760c0d90" } } $('.js-work-strip[data-work-id=4856708]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4856708,"title":"Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat","translated_title":"","metadata":{"grobid_abstract":"Oxygen free radicals are highly reactive species that can cause a wide spectrum of cell damage including lipid peroxidation, enzymes inactivation and DNA damage. Strenuous physical exercise has been shown to impose an oxidative stress on the body due to oxygen free radical generation including an increase in lipid peroxidation. These facts pertain especially to acute or unaccustomed exercise. The purpose of the present study was to examine the effect of the acute swimming exercise on lipid peroxidation. Studies were performed on 20 adult male Swiss albino rats. Animals were divided into 2 groups, 10 rats control group and 9 similar rats exercise group. After exercise blood was taken to measure erythrocyte MDA and haemoglobin levels. Results were expressed as nmol MDAigr Hb. MDA levels from exercise group were not significantly different from control group, with values of 27.4k9.2 and 255.t7.3 nmol MDA/gr Hb respectively (P\u003eO.O5). We concluded that 1 hour swimming exercise doesn't increase lipid peroxidation in erythrocyte.","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Pathophysiology","grobid_abstract_attachment_id":49596184},"translated_abstract":null,"internal_url":"https://www.academia.edu/4856708/Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat","translated_internal_url":"","created_at":"2013-10-22T12:48:03.285-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":6306844,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":29499727,"work_id":4856708,"tagging_user_id":6306844,"tagged_user_id":null,"co_author_invite_id":390162,"email":"r***3@osu.edu","display_order":0,"name":"Sashwati Roy","title":"Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat"},{"id":29499734,"work_id":4856708,"tagging_user_id":6306844,"tagged_user_id":32891153,"co_author_invite_id":null,"email":"m***l@atauni.edu.tr","affiliation":"Ataturk University","display_order":4194304,"name":"Mustafa Gul","title":"Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat"},{"id":29499738,"work_id":4856708,"tagging_user_id":6306844,"tagged_user_id":null,"co_author_invite_id":690204,"email":"o***n@uef.fi","display_order":6291456,"name":"Osmo Hänninen","title":"Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat"},{"id":29499742,"work_id":4856708,"tagging_user_id":6306844,"tagged_user_id":null,"co_author_invite_id":184989,"email":"c***n@osumc.edu","display_order":7340032,"name":"Chandan Sen","title":"Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat"},{"id":29499746,"work_id":4856708,"tagging_user_id":6306844,"tagged_user_id":null,"co_author_invite_id":390945,"email":"m***y@uef.fi","display_order":7864320,"name":"Mustafa Atalay","title":"Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat"}],"downloadable_attachments":[{"id":49596184,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49596184/thumbnails/1.jpg","file_name":"s0928-4680_2898_2980730-x20161014-6497-168onr7.pdf","download_url":"https://www.academia.edu/attachments/49596184/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Endurance_training_may_decrease_oxidativ.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49596184/s0928-4680_2898_2980730-x20161014-6497-168onr7-libre.pdf?1476456266=\u0026response-content-disposition=attachment%3B+filename%3DEndurance_training_may_decrease_oxidativ.pdf\u0026Expires=1734541248\u0026Signature=Ut21soc429pSkhx9hanwGlDsrOyQ8NXD9j5RUS4rVohFiTkEepMHQwNU0Y~z1lAT2LqkBwW8w6oIvVH8ll-NNG1euVltMT8zLFfusMb0li-J4V96oLuAiHZknxrZImDtFQcOCqCdGQfphEo-uewv2cQvMQw49Pmq-Gs8v0DiJvLhGABY6Ec2X6ybemjYFbvimLFpgshMiHqMsqmdzEW8DlJbrn1qCUVy5ipngJ4V5qQkduku638C6SYSPi1cmqK2Q0Im22k3sT3oAxlOHNTURes4GHb4x3-FR4x6ObGLcpha6baP1WwLmlQU0MX9b7ZUT6eHLSF~8iINiG~oOVRQ9w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat","translated_slug":"","page_count":1,"language":"en","content_type":"Work","summary":"Oxygen free radicals are highly reactive species that can cause a wide spectrum of cell damage including lipid peroxidation, enzymes inactivation and DNA damage. Strenuous physical exercise has been shown to impose an oxidative stress on the body due to oxygen free radical generation including an increase in lipid peroxidation. These facts pertain especially to acute or unaccustomed exercise. The purpose of the present study was to examine the effect of the acute swimming exercise on lipid peroxidation. Studies were performed on 20 adult male Swiss albino rats. Animals were divided into 2 groups, 10 rats control group and 9 similar rats exercise group. After exercise blood was taken to measure erythrocyte MDA and haemoglobin levels. Results were expressed as nmol MDAigr Hb. MDA levels from exercise group were not significantly different from control group, with values of 27.4k9.2 and 255.t7.3 nmol MDA/gr Hb respectively (P\u003eO.O5). We concluded that 1 hour swimming exercise doesn't increase lipid peroxidation in erythrocyte.","owner":{"id":6306844,"first_name":"Lena","middle_initials":"","last_name":"Vider","page_name":"LenaVider","domain_name":"griffith","created_at":"2013-10-22T12:44:35.890-07:00","display_name":"Lena Vider","url":"https://griffith.academia.edu/LenaVider"},"attachments":[{"id":49596184,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49596184/thumbnails/1.jpg","file_name":"s0928-4680_2898_2980730-x20161014-6497-168onr7.pdf","download_url":"https://www.academia.edu/attachments/49596184/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Endurance_training_may_decrease_oxidativ.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49596184/s0928-4680_2898_2980730-x20161014-6497-168onr7-libre.pdf?1476456266=\u0026response-content-disposition=attachment%3B+filename%3DEndurance_training_may_decrease_oxidativ.pdf\u0026Expires=1734541248\u0026Signature=Ut21soc429pSkhx9hanwGlDsrOyQ8NXD9j5RUS4rVohFiTkEepMHQwNU0Y~z1lAT2LqkBwW8w6oIvVH8ll-NNG1euVltMT8zLFfusMb0li-J4V96oLuAiHZknxrZImDtFQcOCqCdGQfphEo-uewv2cQvMQw49Pmq-Gs8v0DiJvLhGABY6Ec2X6ybemjYFbvimLFpgshMiHqMsqmdzEW8DlJbrn1qCUVy5ipngJ4V5qQkduku638C6SYSPi1cmqK2Q0Im22k3sT3oAxlOHNTURes4GHb4x3-FR4x6ObGLcpha6baP1WwLmlQU0MX9b7ZUT6eHLSF~8iINiG~oOVRQ9w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":39001,"name":"Pathophysiology","url":"https://www.academia.edu/Documents/in/Pathophysiology"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":790002,"name":"Streptozotocin","url":"https://www.academia.edu/Documents/in/Streptozotocin"},{"id":846529,"name":"Endurance Training","url":"https://www.academia.edu/Documents/in/Endurance_Training"},{"id":1031967,"name":"Diabetic Rat","url":"https://www.academia.edu/Documents/in/Diabetic_Rat"}],"urls":[{"id":1797321,"url":"http://www.sciencedirect.com/science/article/pii/S092846809880730X"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="102790004"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102790004/Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat"><img alt="Research paper thumbnail of Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat" class="work-thumbnail" src="https://attachments.academia-assets.com/102966503/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102790004/Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat">Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat</a></div><div class="wp-workCard_item"><span>Pathophysiology</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dce1b76799fcb6e9dedff0fdca1b06ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102966503,"asset_id":102790004,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102966503/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102790004"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102790004"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102790004; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=102790004]").text(description); $(".js-view-count[data-work-id=102790004]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 102790004; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='102790004']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 102790004, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dce1b76799fcb6e9dedff0fdca1b06ec" } } $('.js-work-strip[data-work-id=102790004]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":102790004,"title":"Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rat","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Pathophysiology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/102790004/Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat","translated_internal_url":"","created_at":"2023-06-03T04:48:38.128-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":102966503,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966503/thumbnails/1.jpg","file_name":"s0928-468028982980730-x20230603-1-ks3l6.pdf","download_url":"https://www.academia.edu/attachments/102966503/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Endurance_training_may_decrease_oxidativ.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966503/s0928-468028982980730-x20230603-1-ks3l6-libre.pdf?1685795371=\u0026response-content-disposition=attachment%3B+filename%3DEndurance_training_may_decrease_oxidativ.pdf\u0026Expires=1734541248\u0026Signature=bayC39ioTiN55AjrsGHEvjFp3hNnwV1uPbDN5nIhitVRU5qnT~j9uoOWTDuHsYAe8NLZINh9GGibGJLIYXxgnqrOGvj1i8bzd~8NTaHTpYnHlmzdl41F2FS5BZ5-h1SvQVse45hUeGBhLm7-u~x5Enk-C5v9MfOlOz5eeZ9qaNiB~rWXxKuqUwsak-d~Fv1x-t-E9MzoOktUkAHHDmWQH6FKcheuSV~BsLCLwoOxCFLzh3wghd917JlPryXp53i4J6asA-eQMgKY4trHiPzoPTdUv4~~iHNlv3mjs8eTGLAeihg6s5kx7Ic-8dXmyvou2HW4iDf2JqvGPR3OMS0EXA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Endurance_training_may_decrease_oxidative_stress_in_streptozotocin_induced_diabetic_rat","translated_slug":"","page_count":1,"language":"en","content_type":"Work","summary":null,"owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":102966503,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966503/thumbnails/1.jpg","file_name":"s0928-468028982980730-x20230603-1-ks3l6.pdf","download_url":"https://www.academia.edu/attachments/102966503/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Endurance_training_may_decrease_oxidativ.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966503/s0928-468028982980730-x20230603-1-ks3l6-libre.pdf?1685795371=\u0026response-content-disposition=attachment%3B+filename%3DEndurance_training_may_decrease_oxidativ.pdf\u0026Expires=1734541248\u0026Signature=bayC39ioTiN55AjrsGHEvjFp3hNnwV1uPbDN5nIhitVRU5qnT~j9uoOWTDuHsYAe8NLZINh9GGibGJLIYXxgnqrOGvj1i8bzd~8NTaHTpYnHlmzdl41F2FS5BZ5-h1SvQVse45hUeGBhLm7-u~x5Enk-C5v9MfOlOz5eeZ9qaNiB~rWXxKuqUwsak-d~Fv1x-t-E9MzoOktUkAHHDmWQH6FKcheuSV~BsLCLwoOxCFLzh3wghd917JlPryXp53i4J6asA-eQMgKY4trHiPzoPTdUv4~~iHNlv3mjs8eTGLAeihg6s5kx7Ic-8dXmyvou2HW4iDf2JqvGPR3OMS0EXA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":39001,"name":"Pathophysiology","url":"https://www.academia.edu/Documents/in/Pathophysiology"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":790002,"name":"Streptozotocin","url":"https://www.academia.edu/Documents/in/Streptozotocin"},{"id":846529,"name":"Endurance Training","url":"https://www.academia.edu/Documents/in/Endurance_Training"},{"id":1031967,"name":"Diabetic Rat","url":"https://www.academia.edu/Documents/in/Diabetic_Rat"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="102790003"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102790003/Toxicity_of_some_bis_mannich_bases_and_corresponding_piperidinols_in_the_brine_shrimp_Artemia_salina_Bioassay"><img alt="Research paper thumbnail of Toxicity of some bis mannich bases and corresponding piperidinols in the brine shrimp (Artemia salina) Bioassay" class="work-thumbnail" src="https://attachments.academia-assets.com/102966703/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102790003/Toxicity_of_some_bis_mannich_bases_and_corresponding_piperidinols_in_the_brine_shrimp_Artemia_salina_Bioassay">Toxicity of some bis mannich bases and corresponding piperidinols in the brine shrimp (Artemia salina) Bioassay</a></div><div class="wp-workCard_item"><span>Journal of Applied Toxicology</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Some acetophenone-derived bis Mannich bases were synthesized: bis[beta-benzoylethyl]ethylamine hy...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Some acetophenone-derived bis Mannich bases were synthesized: bis[beta-benzoylethyl]ethylamine hydrochloride (IIa), bis[beta-(p-methylbenzoyl)ethyl]ethylamine hydrochloride (IIb), bis[beta-(p-chlorobenzoyl)ethyl]ethy- lamine hydrochloride (IId), bis[(2-thienylcarbonyl)ethyl]ethylamine hydrochloride (IIe); some corresponding piperidinol derivatives: 3-benzoyl-1-ethyl-4-phenyl-4-piperidinol hydrochloride (IIIa), 1-ethyl-3-(p-methyl- benzoyl)-4-(p-methylphenyl)-4-piperidinol hydrochloride (IIIb), 1-ethyl-3-(p-methoxybenzoyl)-4-(p-methoxy- phenyl)-4-piperidinol hydrochloride (IIIc), 1-ethyl-3-(p-chlorobenzoyl)-4-(p-chlorophenyl)-4-piperidinol hydrochloride (IIId), 1-ethyl-4-(2-thienyl)-3-(2-thienylcarbonyl)-4-piperidinol hydrochloride (IIIe); and some representative quaternary piperidinols: 3-benzoyl-1-ethyl-4-hydroxy-1-methyl-4-phenylpiperidinium iodide (IIIf), 1-ethyl-4-hydroxy-1-methyl-3-(p-methylbenzoyl)-4-(p-methylphenyl)piperidinium iodide (IIIg). Toxicity was tested by the brine shrimp bioassay as an intermediate test before further in vivo animal experiments. Piperidine derivatives were found to be more potent than bis Mannich bases. Quaternary piperidine derivatives IIIf and IIIg and also non-quaternary piperidine derivatives IIIb, IIIe, IIIc and IIId were more toxic than 5-fluorouracil in brine shrimp bioassay. Except for IIe, bis Mannich bases were not effective. Quaternization and conversion of bis Mannich bases to corresponding piperidines improved the toxicity. The lipid solubility of the compounds may not affect the toxicity. From these findings the quaternary piperidine derivatives IIIf and IIIg could be used in further drug development and also for in vivo experiments.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1269974ee7276ebc1c32e186aceb22ed" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102966703,"asset_id":102790003,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102966703/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102790003"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102790003"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102790003; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=102790003]").text(description); $(".js-view-count[data-work-id=102790003]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 102790003; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='102790003']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 102790003, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1269974ee7276ebc1c32e186aceb22ed" } } $('.js-work-strip[data-work-id=102790003]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":102790003,"title":"Toxicity of some bis mannich bases and corresponding piperidinols in the brine shrimp (Artemia salina) Bioassay","translated_title":"","metadata":{"abstract":"Some acetophenone-derived bis Mannich bases were synthesized: bis[beta-benzoylethyl]ethylamine hydrochloride (IIa), bis[beta-(p-methylbenzoyl)ethyl]ethylamine hydrochloride (IIb), bis[beta-(p-chlorobenzoyl)ethyl]ethy- lamine hydrochloride (IId), bis[(2-thienylcarbonyl)ethyl]ethylamine hydrochloride (IIe); some corresponding piperidinol derivatives: 3-benzoyl-1-ethyl-4-phenyl-4-piperidinol hydrochloride (IIIa), 1-ethyl-3-(p-methyl- benzoyl)-4-(p-methylphenyl)-4-piperidinol hydrochloride (IIIb), 1-ethyl-3-(p-methoxybenzoyl)-4-(p-methoxy- phenyl)-4-piperidinol hydrochloride (IIIc), 1-ethyl-3-(p-chlorobenzoyl)-4-(p-chlorophenyl)-4-piperidinol hydrochloride (IIId), 1-ethyl-4-(2-thienyl)-3-(2-thienylcarbonyl)-4-piperidinol hydrochloride (IIIe); and some representative quaternary piperidinols: 3-benzoyl-1-ethyl-4-hydroxy-1-methyl-4-phenylpiperidinium iodide (IIIf), 1-ethyl-4-hydroxy-1-methyl-3-(p-methylbenzoyl)-4-(p-methylphenyl)piperidinium iodide (IIIg). Toxicity was tested by the brine shrimp bioassay as an intermediate test before further in vivo animal experiments. Piperidine derivatives were found to be more potent than bis Mannich bases. Quaternary piperidine derivatives IIIf and IIIg and also non-quaternary piperidine derivatives IIIb, IIIe, IIIc and IIId were more toxic than 5-fluorouracil in brine shrimp bioassay. Except for IIe, bis Mannich bases were not effective. Quaternization and conversion of bis Mannich bases to corresponding piperidines improved the toxicity. The lipid solubility of the compounds may not affect the toxicity. From these findings the quaternary piperidine derivatives IIIf and IIIg could be used in further drug development and also for in vivo experiments.","publisher":"Wiley-Blackwell","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Journal of Applied Toxicology"},"translated_abstract":"Some acetophenone-derived bis Mannich bases were synthesized: bis[beta-benzoylethyl]ethylamine hydrochloride (IIa), bis[beta-(p-methylbenzoyl)ethyl]ethylamine hydrochloride (IIb), bis[beta-(p-chlorobenzoyl)ethyl]ethy- lamine hydrochloride (IId), bis[(2-thienylcarbonyl)ethyl]ethylamine hydrochloride (IIe); some corresponding piperidinol derivatives: 3-benzoyl-1-ethyl-4-phenyl-4-piperidinol hydrochloride (IIIa), 1-ethyl-3-(p-methyl- benzoyl)-4-(p-methylphenyl)-4-piperidinol hydrochloride (IIIb), 1-ethyl-3-(p-methoxybenzoyl)-4-(p-methoxy- phenyl)-4-piperidinol hydrochloride (IIIc), 1-ethyl-3-(p-chlorobenzoyl)-4-(p-chlorophenyl)-4-piperidinol hydrochloride (IIId), 1-ethyl-4-(2-thienyl)-3-(2-thienylcarbonyl)-4-piperidinol hydrochloride (IIIe); and some representative quaternary piperidinols: 3-benzoyl-1-ethyl-4-hydroxy-1-methyl-4-phenylpiperidinium iodide (IIIf), 1-ethyl-4-hydroxy-1-methyl-3-(p-methylbenzoyl)-4-(p-methylphenyl)piperidinium iodide (IIIg). Toxicity was tested by the brine shrimp bioassay as an intermediate test before further in vivo animal experiments. Piperidine derivatives were found to be more potent than bis Mannich bases. Quaternary piperidine derivatives IIIf and IIIg and also non-quaternary piperidine derivatives IIIb, IIIe, IIIc and IIId were more toxic than 5-fluorouracil in brine shrimp bioassay. Except for IIe, bis Mannich bases were not effective. Quaternization and conversion of bis Mannich bases to corresponding piperidines improved the toxicity. The lipid solubility of the compounds may not affect the toxicity. From these findings the quaternary piperidine derivatives IIIf and IIIg could be used in further drug development and also for in vivo experiments.","internal_url":"https://www.academia.edu/102790003/Toxicity_of_some_bis_mannich_bases_and_corresponding_piperidinols_in_the_brine_shrimp_Artemia_salina_Bioassay","translated_internal_url":"","created_at":"2023-06-03T04:48:37.957-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":102966703,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966703/thumbnails/1.jpg","file_name":"Gul_HI_et_al._JAT_2003.pdf","download_url":"https://www.academia.edu/attachments/102966703/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Toxicity_of_some_bis_mannich_bases_and_c.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966703/Gul_HI_et_al._JAT_2003-libre.pdf?1685795324=\u0026response-content-disposition=attachment%3B+filename%3DToxicity_of_some_bis_mannich_bases_and_c.pdf\u0026Expires=1734541248\u0026Signature=hSO-~GoMJN-RR-mQPpENsugBR-Bo91qtBgc8D1tYqKxvF0QExZGKPWSxcfuq0ld-1BltcU2CISlAcVp40N4PFXzME~QoXkNscX6KsN73hooEvyNkHB~SsY9mD~UJjAPsSI~XEVC9xgVO9RlmUypVtRsdw3M4zoMbwIHA~SyCHUzLv1iFNRmHuQIRdk9jJQVCuGfkDpc2L7154kma8ztOn8Pzq44hhJo8ysjwkieSjPuC49~n6xwLRAGVObcUb1iZfI6~T4NhAoh3hAqFyWb2SMN~CleUWW3yMT8Lz82Sx1BPl75lX3vhOR2luDkrfEq8bcidCl-Cbg56nmg-04vMnw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Toxicity_of_some_bis_mannich_bases_and_corresponding_piperidinols_in_the_brine_shrimp_Artemia_salina_Bioassay","translated_slug":"","page_count":5,"language":"en","content_type":"Work","summary":"Some acetophenone-derived bis Mannich bases were synthesized: bis[beta-benzoylethyl]ethylamine hydrochloride (IIa), bis[beta-(p-methylbenzoyl)ethyl]ethylamine hydrochloride (IIb), bis[beta-(p-chlorobenzoyl)ethyl]ethy- lamine hydrochloride (IId), bis[(2-thienylcarbonyl)ethyl]ethylamine hydrochloride (IIe); some corresponding piperidinol derivatives: 3-benzoyl-1-ethyl-4-phenyl-4-piperidinol hydrochloride (IIIa), 1-ethyl-3-(p-methyl- benzoyl)-4-(p-methylphenyl)-4-piperidinol hydrochloride (IIIb), 1-ethyl-3-(p-methoxybenzoyl)-4-(p-methoxy- phenyl)-4-piperidinol hydrochloride (IIIc), 1-ethyl-3-(p-chlorobenzoyl)-4-(p-chlorophenyl)-4-piperidinol hydrochloride (IIId), 1-ethyl-4-(2-thienyl)-3-(2-thienylcarbonyl)-4-piperidinol hydrochloride (IIIe); and some representative quaternary piperidinols: 3-benzoyl-1-ethyl-4-hydroxy-1-methyl-4-phenylpiperidinium iodide (IIIf), 1-ethyl-4-hydroxy-1-methyl-3-(p-methylbenzoyl)-4-(p-methylphenyl)piperidinium iodide (IIIg). Toxicity was tested by the brine shrimp bioassay as an intermediate test before further in vivo animal experiments. Piperidine derivatives were found to be more potent than bis Mannich bases. Quaternary piperidine derivatives IIIf and IIIg and also non-quaternary piperidine derivatives IIIb, IIIe, IIIc and IIId were more toxic than 5-fluorouracil in brine shrimp bioassay. Except for IIe, bis Mannich bases were not effective. Quaternization and conversion of bis Mannich bases to corresponding piperidines improved the toxicity. The lipid solubility of the compounds may not affect the toxicity. From these findings the quaternary piperidine derivatives IIIf and IIIg could be used in further drug development and also for in vivo experiments.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":102966703,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966703/thumbnails/1.jpg","file_name":"Gul_HI_et_al._JAT_2003.pdf","download_url":"https://www.academia.edu/attachments/102966703/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Toxicity_of_some_bis_mannich_bases_and_c.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966703/Gul_HI_et_al._JAT_2003-libre.pdf?1685795324=\u0026response-content-disposition=attachment%3B+filename%3DToxicity_of_some_bis_mannich_bases_and_c.pdf\u0026Expires=1734541248\u0026Signature=hSO-~GoMJN-RR-mQPpENsugBR-Bo91qtBgc8D1tYqKxvF0QExZGKPWSxcfuq0ld-1BltcU2CISlAcVp40N4PFXzME~QoXkNscX6KsN73hooEvyNkHB~SsY9mD~UJjAPsSI~XEVC9xgVO9RlmUypVtRsdw3M4zoMbwIHA~SyCHUzLv1iFNRmHuQIRdk9jJQVCuGfkDpc2L7154kma8ztOn8Pzq44hhJo8ysjwkieSjPuC49~n6xwLRAGVObcUb1iZfI6~T4NhAoh3hAqFyWb2SMN~CleUWW3yMT8Lz82Sx1BPl75lX3vhOR2luDkrfEq8bcidCl-Cbg56nmg-04vMnw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":2215,"name":"Water","url":"https://www.academia.edu/Documents/in/Water"},{"id":8058,"name":"Artemia","url":"https://www.academia.edu/Documents/in/Artemia"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":61214,"name":"Longevity","url":"https://www.academia.edu/Documents/in/Longevity"},{"id":67405,"name":"Toxicity","url":"https://www.academia.edu/Documents/in/Toxicity"},{"id":205581,"name":"Partition Coefficient","url":"https://www.academia.edu/Documents/in/Partition_Coefficient"},{"id":205584,"name":"Solubility","url":"https://www.academia.edu/Documents/in/Solubility"},{"id":382529,"name":"Artemia salina","url":"https://www.academia.edu/Documents/in/Artemia_salina"},{"id":695018,"name":"Molecular weight","url":"https://www.academia.edu/Documents/in/Molecular_weight"},{"id":951749,"name":"Ambroxol Hydrochloride","url":"https://www.academia.edu/Documents/in/Ambroxol_Hydrochloride"},{"id":980394,"name":"Acute Toxicity","url":"https://www.academia.edu/Documents/in/Acute_Toxicity"},{"id":1109769,"name":"Biological Assay","url":"https://www.academia.edu/Documents/in/Biological_Assay"},{"id":1377823,"name":"Applied Toxicology","url":"https://www.academia.edu/Documents/in/Applied_Toxicology"},{"id":1880638,"name":"Piperidines","url":"https://www.academia.edu/Documents/in/Piperidines"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="102790002"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102790002/Syntheses_and_Stability_Studies_of_Some_Mannich_Bases_of_Acetophenones_and_Evaluation_of_their_Cytotoxicity_against_Jurkat_Cells"><img alt="Research paper thumbnail of Syntheses and Stability Studies of Some Mannich Bases of Acetophenones and Evaluation of their Cytotoxicity against Jurkat Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/102966498/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102790002/Syntheses_and_Stability_Studies_of_Some_Mannich_Bases_of_Acetophenones_and_Evaluation_of_their_Cytotoxicity_against_Jurkat_Cells">Syntheses and Stability Studies of Some Mannich Bases of Acetophenones and Evaluation of their Cytotoxicity against Jurkat Cells</a></div><div class="wp-workCard_item"><span>Arzneimittelforschung</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="21eb5fcd49c2b9f93e6e29fc50f2ac5a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102966498,"asset_id":102790002,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102966498/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102790002"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102790002"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102790002; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=102790002]").text(description); $(".js-view-count[data-work-id=102790002]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 102790002; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='102790002']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 102790002, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "21eb5fcd49c2b9f93e6e29fc50f2ac5a" } } $('.js-work-strip[data-work-id=102790002]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":102790002,"title":"Syntheses and Stability Studies of Some Mannich Bases of Acetophenones and Evaluation of their Cytotoxicity against Jurkat Cells","translated_title":"","metadata":{"publisher":"Georg Thieme Verlag KG","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Arzneimittelforschung"},"translated_abstract":null,"internal_url":"https://www.academia.edu/102790002/Syntheses_and_Stability_Studies_of_Some_Mannich_Bases_of_Acetophenones_and_Evaluation_of_their_Cytotoxicity_against_Jurkat_Cells","translated_internal_url":"","created_at":"2023-06-03T04:48:37.705-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":102966498,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966498/thumbnails/1.jpg","file_name":"chin.20024611220230603-1-i49wvi.pdf","download_url":"https://www.academia.edu/attachments/102966498/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Syntheses_and_Stability_Studies_of_Some.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966498/chin.20024611220230603-1-i49wvi-libre.pdf?1685795370=\u0026response-content-disposition=attachment%3B+filename%3DSyntheses_and_Stability_Studies_of_Some.pdf\u0026Expires=1734541248\u0026Signature=Mnl8yRdhXPbrC1hs23-fVal~puQk0xsBEZECdUUsrfsq2nCY9OncEy8~NC3CcSL4JleceOchP5-UUQpZARpl7LL7~p6CB8TRu4lEzE-j-Wj03ioQGOR9pKwx1y7nom21ptGhU2evhWOcGG-XNEP1l9zRPEjxmn55gPNiaKtWIX~-6iLeQCZ5hpzfGNcVfRgcFR9VtIxgwvnmc6FJYCwREG94CC6ZgVIEUSwqGDDzTvHKOBMU1qvQraRl8JPSP5fAB7TGaGBxH5tDlghxxpp6~OS5yVsnZX-BjCE6cBkFtQFtDJnD~m-Gj0Wl2SVIAllMavFjlqtqdvLC1oUUySbNXg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Syntheses_and_Stability_Studies_of_Some_Mannich_Bases_of_Acetophenones_and_Evaluation_of_their_Cytotoxicity_against_Jurkat_Cells","translated_slug":"","page_count":1,"language":"en","content_type":"Work","summary":null,"owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":102966498,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966498/thumbnails/1.jpg","file_name":"chin.20024611220230603-1-i49wvi.pdf","download_url":"https://www.academia.edu/attachments/102966498/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Syntheses_and_Stability_Studies_of_Some.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966498/chin.20024611220230603-1-i49wvi-libre.pdf?1685795370=\u0026response-content-disposition=attachment%3B+filename%3DSyntheses_and_Stability_Studies_of_Some.pdf\u0026Expires=1734541248\u0026Signature=Mnl8yRdhXPbrC1hs23-fVal~puQk0xsBEZECdUUsrfsq2nCY9OncEy8~NC3CcSL4JleceOchP5-UUQpZARpl7LL7~p6CB8TRu4lEzE-j-Wj03ioQGOR9pKwx1y7nom21ptGhU2evhWOcGG-XNEP1l9zRPEjxmn55gPNiaKtWIX~-6iLeQCZ5hpzfGNcVfRgcFR9VtIxgwvnmc6FJYCwREG94CC6ZgVIEUSwqGDDzTvHKOBMU1qvQraRl8JPSP5fAB7TGaGBxH5tDlghxxpp6~OS5yVsnZX-BjCE6cBkFtQFtDJnD~m-Gj0Wl2SVIAllMavFjlqtqdvLC1oUUySbNXg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":22050,"name":"Cytotoxicity","url":"https://www.academia.edu/Documents/in/Cytotoxicity"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":42135,"name":"Drug","url":"https://www.academia.edu/Documents/in/Drug"},{"id":59370,"name":"In Vitro","url":"https://www.academia.edu/Documents/in/In_Vitro"},{"id":114715,"name":"Stereochemistry","url":"https://www.academia.edu/Documents/in/Stereochemistry"},{"id":172024,"name":"Analog","url":"https://www.academia.edu/Documents/in/Analog"},{"id":582465,"name":"Cyclization","url":"https://www.academia.edu/Documents/in/Cyclization"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship"},{"id":1135814,"name":"Drug Stability","url":"https://www.academia.edu/Documents/in/Drug_Stability"},{"id":1152821,"name":"Chemical Synthesis","url":"https://www.academia.edu/Documents/in/Chemical_Synthesis"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents"},{"id":2814759,"name":"Ethylamine","url":"https://www.academia.edu/Documents/in/Ethylamine"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":31972031,"url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0031-1299942.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="102789946"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/102789946/Sorafenib_Alleviates_Inflammatory_Signaling_of_Tumor_Microenvironment_in_Precancerous_Lung_Injuries"><img alt="Research paper thumbnail of Sorafenib Alleviates Inflammatory Signaling of Tumor Microenvironment in Precancerous Lung Injuries" class="work-thumbnail" src="https://attachments.academia-assets.com/102966450/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/102789946/Sorafenib_Alleviates_Inflammatory_Signaling_of_Tumor_Microenvironment_in_Precancerous_Lung_Injuries">Sorafenib Alleviates Inflammatory Signaling of Tumor Microenvironment in Precancerous Lung Injuries</a></div><div class="wp-workCard_item"><span>Pharmaceuticals</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">According to population-based studies, lung cancer is the prominent reason for cancer-related mor...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">According to population-based studies, lung cancer is the prominent reason for cancer-related mortality worldwide in males and is also rising in females at an alarming rate. Sorafenib (SOR), which is approved for the treatment of hepatocellular carcinoma and renal cell carcinoma, is a multitargeted protein kinase inhibitor. Additionally, SOR is the subject of interest for preclinical and clinical trials in lung cancer. This study was designed to assess in vivo the possible effects of sorafenib (SOR) in diethylnitrosamine (DEN)-induced lung carcinogenesis and examine its probable mechanisms of action. A total of 30 adult male rats were divided into three groups (1) control, (2) DEN, and (3) DEN + SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum and lung tissue samples were analyzed to d...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b83f9b2e93b6795b38a5fe0239a994c4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":102966450,"asset_id":102789946,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/102966450/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="102789946"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="102789946"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 102789946; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=102789946]").text(description); $(".js-view-count[data-work-id=102789946]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 102789946; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='102789946']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 102789946, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b83f9b2e93b6795b38a5fe0239a994c4" } } $('.js-work-strip[data-work-id=102789946]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":102789946,"title":"Sorafenib Alleviates Inflammatory Signaling of Tumor Microenvironment in Precancerous Lung Injuries","translated_title":"","metadata":{"abstract":"According to population-based studies, lung cancer is the prominent reason for cancer-related mortality worldwide in males and is also rising in females at an alarming rate. Sorafenib (SOR), which is approved for the treatment of hepatocellular carcinoma and renal cell carcinoma, is a multitargeted protein kinase inhibitor. Additionally, SOR is the subject of interest for preclinical and clinical trials in lung cancer. This study was designed to assess in vivo the possible effects of sorafenib (SOR) in diethylnitrosamine (DEN)-induced lung carcinogenesis and examine its probable mechanisms of action. A total of 30 adult male rats were divided into three groups (1) control, (2) DEN, and (3) DEN + SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum and lung tissue samples were analyzed to d...","publisher":"MDPI AG","publication_name":"Pharmaceuticals"},"translated_abstract":"According to population-based studies, lung cancer is the prominent reason for cancer-related mortality worldwide in males and is also rising in females at an alarming rate. Sorafenib (SOR), which is approved for the treatment of hepatocellular carcinoma and renal cell carcinoma, is a multitargeted protein kinase inhibitor. Additionally, SOR is the subject of interest for preclinical and clinical trials in lung cancer. This study was designed to assess in vivo the possible effects of sorafenib (SOR) in diethylnitrosamine (DEN)-induced lung carcinogenesis and examine its probable mechanisms of action. A total of 30 adult male rats were divided into three groups (1) control, (2) DEN, and (3) DEN + SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum and lung tissue samples were analyzed to d...","internal_url":"https://www.academia.edu/102789946/Sorafenib_Alleviates_Inflammatory_Signaling_of_Tumor_Microenvironment_in_Precancerous_Lung_Injuries","translated_internal_url":"","created_at":"2023-06-03T04:47:11.056-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":102966450,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966450/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/102966450/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Sorafenib_Alleviates_Inflammatory_Signal.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966450/pdf-libre.pdf?1685795396=\u0026response-content-disposition=attachment%3B+filename%3DSorafenib_Alleviates_Inflammatory_Signal.pdf\u0026Expires=1734541248\u0026Signature=A6A3gEudXNBTMu~wDzOVKRKbxsU5znM1cb~-FRhu4Qqi-nHFe4SbvU-b6UHyyRAaJQ~JUS9zGPoTjYmnxMg4NKAxoGVy-dbPF760wXDA1rVGhLbIKruCOkB6Idri30gn7RXprK049jrZWI-E2OJXbmhorXIt5IQiFd6z~LGCJQgboPLBMZ0i4X3vfdXIh7TR3HSPxiCZZngnjc6zQPOZrSIWsJzppaujf39mT8RFw6I~ogccAwxFN7q8K3ep3BcloSMGyBDAbl4jfAHeAuFcz88U~SRMcII8n3UQLjdx7JGOYaJLxLV9TUarMPQfA8nn3u6g4bEup8ulKZqt~Um-1A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Sorafenib_Alleviates_Inflammatory_Signaling_of_Tumor_Microenvironment_in_Precancerous_Lung_Injuries","translated_slug":"","page_count":14,"language":"en","content_type":"Work","summary":"According to population-based studies, lung cancer is the prominent reason for cancer-related mortality worldwide in males and is also rising in females at an alarming rate. Sorafenib (SOR), which is approved for the treatment of hepatocellular carcinoma and renal cell carcinoma, is a multitargeted protein kinase inhibitor. Additionally, SOR is the subject of interest for preclinical and clinical trials in lung cancer. This study was designed to assess in vivo the possible effects of sorafenib (SOR) in diethylnitrosamine (DEN)-induced lung carcinogenesis and examine its probable mechanisms of action. A total of 30 adult male rats were divided into three groups (1) control, (2) DEN, and (3) DEN + SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum and lung tissue samples were analyzed to d...","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":102966450,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/102966450/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/102966450/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Sorafenib_Alleviates_Inflammatory_Signal.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/102966450/pdf-libre.pdf?1685795396=\u0026response-content-disposition=attachment%3B+filename%3DSorafenib_Alleviates_Inflammatory_Signal.pdf\u0026Expires=1734541248\u0026Signature=A6A3gEudXNBTMu~wDzOVKRKbxsU5znM1cb~-FRhu4Qqi-nHFe4SbvU-b6UHyyRAaJQ~JUS9zGPoTjYmnxMg4NKAxoGVy-dbPF760wXDA1rVGhLbIKruCOkB6Idri30gn7RXprK049jrZWI-E2OJXbmhorXIt5IQiFd6z~LGCJQgboPLBMZ0i4X3vfdXIh7TR3HSPxiCZZngnjc6zQPOZrSIWsJzppaujf39mT8RFw6I~ogccAwxFN7q8K3ep3BcloSMGyBDAbl4jfAHeAuFcz88U~SRMcII8n3UQLjdx7JGOYaJLxLV9TUarMPQfA8nn3u6g4bEup8ulKZqt~Um-1A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51698,"name":"Lung Cancer","url":"https://www.academia.edu/Documents/in/Lung_Cancer"},{"id":54650,"name":"Pharmaceuticals","url":"https://www.academia.edu/Documents/in/Pharmaceuticals"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung"},{"id":340262,"name":"Carcinogenesis","url":"https://www.academia.edu/Documents/in/Carcinogenesis"},{"id":1003057,"name":"Sorafenib","url":"https://www.academia.edu/Documents/in/Sorafenib"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":31971998,"url":"https://www.mdpi.com/1424-8247/16/2/221/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95720747"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95720747/Ulusal_Spor_Bilimleri_Dergisi"><img alt="Research paper thumbnail of Ulusal Spor Bilimleri Dergisi" class="work-thumbnail" src="https://attachments.academia-assets.com/97824795/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95720747/Ulusal_Spor_Bilimleri_Dergisi">Ulusal Spor Bilimleri Dergisi</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Yüksek yoğunluklu egzersiz sırasında (örneğin, laktat eşiğinin üzerinde çalışmak) kasılan iskelet...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Yüksek yoğunluklu egzersiz sırasında (örneğin, laktat eşiğinin üzerinde çalışmak) kasılan iskelet kasları, önemli miktarda hidrojen (H +) iyonu birikimine sebep olur. Bu H + iyonları, egzersize bağlı metabolik asidozun gelişmesine ve asit-baz homeostazının bozulmasına sebep olabilir. Dolayısıyla bu çalışmanın amacı (a) egzersize bağlı vücut pH seviyesinde meydana gelen değişimlerin fizyolojik mekanizmasını ve sportif performansa etkisini, (b) egzersize bağlı asit-baz homeostazında görülen değişimlerin fizyolojik mekanizmasını ve sportif performansa etkisini ve (c) bahsedilen fizyolojik olayların olumsuz etkilerinin minimize edilmesi için kullanılabilecek besin takviyelerini güncel literatür ışığında incelemeyi amaçlamıştır. Bu derleme çalışmasında egzersiz ve asit-baz dengesi, egzersize bağlı asit-baz bozuklukları ile ilgili konuları içeren bilimsel metinler ve kitaplar incelenmiştir. Pub Med, Web of Science, Medline, Cochrane Library, Google Scholar ve ULAKBİM elektronik veri tabanları "exercise and pH balance", "acidosis and exercise", "exercise and acid-base balance", "athletic performance and fluid balance", "sport supplements for asid-base balance", "sports beverage for athletes'' ve "nutritional strategies for acid-base balance" anahtar kelimeleri kullanılarak taranmıştır. Metabolik asidozla birlikte sporcularda yorgunluk hissi, kaslardaki mekanik performansın azalması gibi etmenler dolayısıyla egzersiz performansını da olumsuz etkiler. Bu nedenle sporcular tarafından yüksek şiddetli egzersizlerde bozulabilecek asit-baz homeostazı için destekleyici besinsel takviyelerin kullanılması (sodyum bikarbonat, sodyum sitrat, beta alanin vb.) sportif performansın optimal biçimde sürdürülebilmesi, oluşabilecek yorgunluğun geciktirilebilmesi ve performansın artırılması için tavsiye edilen alternatiflerdir.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e44dbf90db6bb87dbedfc2d1ccc6049e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97824795,"asset_id":95720747,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97824795/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95720747"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95720747"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95720747; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95720747]").text(description); $(".js-view-count[data-work-id=95720747]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95720747; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95720747']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95720747, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e44dbf90db6bb87dbedfc2d1ccc6049e" } } $('.js-work-strip[data-work-id=95720747]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95720747,"title":"Ulusal Spor Bilimleri Dergisi","translated_title":"","metadata":{"grobid_abstract":"Yüksek yoğunluklu egzersiz sırasında (örneğin, laktat eşiğinin üzerinde çalışmak) kasılan iskelet kasları, önemli miktarda hidrojen (H +) iyonu birikimine sebep olur. Bu H + iyonları, egzersize bağlı metabolik asidozun gelişmesine ve asit-baz homeostazının bozulmasına sebep olabilir. Dolayısıyla bu çalışmanın amacı (a) egzersize bağlı vücut pH seviyesinde meydana gelen değişimlerin fizyolojik mekanizmasını ve sportif performansa etkisini, (b) egzersize bağlı asit-baz homeostazında görülen değişimlerin fizyolojik mekanizmasını ve sportif performansa etkisini ve (c) bahsedilen fizyolojik olayların olumsuz etkilerinin minimize edilmesi için kullanılabilecek besin takviyelerini güncel literatür ışığında incelemeyi amaçlamıştır. Bu derleme çalışmasında egzersiz ve asit-baz dengesi, egzersize bağlı asit-baz bozuklukları ile ilgili konuları içeren bilimsel metinler ve kitaplar incelenmiştir. Pub Med, Web of Science, Medline, Cochrane Library, Google Scholar ve ULAKBİM elektronik veri tabanları \"exercise and pH balance\", \"acidosis and exercise\", \"exercise and acid-base balance\", \"athletic performance and fluid balance\", \"sport supplements for asid-base balance\", \"sports beverage for athletes'' ve \"nutritional strategies for acid-base balance\" anahtar kelimeleri kullanılarak taranmıştır. Metabolik asidozla birlikte sporcularda yorgunluk hissi, kaslardaki mekanik performansın azalması gibi etmenler dolayısıyla egzersiz performansını da olumsuz etkiler. Bu nedenle sporcular tarafından yüksek şiddetli egzersizlerde bozulabilecek asit-baz homeostazı için destekleyici besinsel takviyelerin kullanılması (sodyum bikarbonat, sodyum sitrat, beta alanin vb.) sportif performansın optimal biçimde sürdürülebilmesi, oluşabilecek yorgunluğun geciktirilebilmesi ve performansın artırılması için tavsiye edilen alternatiflerdir.","grobid_abstract_attachment_id":97824795},"translated_abstract":null,"internal_url":"https://www.academia.edu/95720747/Ulusal_Spor_Bilimleri_Dergisi","translated_internal_url":"","created_at":"2023-01-26T02:19:41.429-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97824795,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97824795/thumbnails/1.jpg","file_name":"Gencoglu_C._et_al._Egzersizde_Asit_Baz_Homeostazi_Bir_Geleneksel_Derleme_Ulusal_Spor_Bilimleri_Dergisi_2022.pdf","download_url":"https://www.academia.edu/attachments/97824795/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Ulusal_Spor_Bilimleri_Dergisi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97824795/Gencoglu_C._et_al._Egzersizde_Asit_Baz_Homeostazi_Bir_Geleneksel_Derleme_Ulusal_Spor_Bilimleri_Dergisi_2022-libre.pdf?1674731356=\u0026response-content-disposition=attachment%3B+filename%3DUlusal_Spor_Bilimleri_Dergisi.pdf\u0026Expires=1734541248\u0026Signature=G22S-3mNS7ZxM~UI845hx~CjLw93BV-RMNRY3wTedIVKjmqgBEhSU2N7hxvNpxjJHrrM8J~TpjZxcAmg9xSfGKkGaa8nL35q4pSjI2V43RDacg2aFknhfx9IoBrJkIhv21b5QeWmj8Kuu5d9l3flqplaYKdJWQbToKrQDVy~bnGMX-ELqtdj3Sab4~rF7NF1mBp2qecduslgDtyy2eo2k4fS-OdMy2h9ohxSy7ACqLeKrrpwEvrcJEX-A6hGfbh5iLTZoL6LyeXOqt2O6dXCEO1bp8wrBYVp6pT5rliWUVEwVIHEa6giL~V~tYbvVnLYN4uRUxNjO08ez2BpBKRy3Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Ulusal_Spor_Bilimleri_Dergisi","translated_slug":"","page_count":21,"language":"tr","content_type":"Work","summary":"Yüksek yoğunluklu egzersiz sırasında (örneğin, laktat eşiğinin üzerinde çalışmak) kasılan iskelet kasları, önemli miktarda hidrojen (H +) iyonu birikimine sebep olur. Bu H + iyonları, egzersize bağlı metabolik asidozun gelişmesine ve asit-baz homeostazının bozulmasına sebep olabilir. Dolayısıyla bu çalışmanın amacı (a) egzersize bağlı vücut pH seviyesinde meydana gelen değişimlerin fizyolojik mekanizmasını ve sportif performansa etkisini, (b) egzersize bağlı asit-baz homeostazında görülen değişimlerin fizyolojik mekanizmasını ve sportif performansa etkisini ve (c) bahsedilen fizyolojik olayların olumsuz etkilerinin minimize edilmesi için kullanılabilecek besin takviyelerini güncel literatür ışığında incelemeyi amaçlamıştır. Bu derleme çalışmasında egzersiz ve asit-baz dengesi, egzersize bağlı asit-baz bozuklukları ile ilgili konuları içeren bilimsel metinler ve kitaplar incelenmiştir. Pub Med, Web of Science, Medline, Cochrane Library, Google Scholar ve ULAKBİM elektronik veri tabanları \"exercise and pH balance\", \"acidosis and exercise\", \"exercise and acid-base balance\", \"athletic performance and fluid balance\", \"sport supplements for asid-base balance\", \"sports beverage for athletes'' ve \"nutritional strategies for acid-base balance\" anahtar kelimeleri kullanılarak taranmıştır. Metabolik asidozla birlikte sporcularda yorgunluk hissi, kaslardaki mekanik performansın azalması gibi etmenler dolayısıyla egzersiz performansını da olumsuz etkiler. Bu nedenle sporcular tarafından yüksek şiddetli egzersizlerde bozulabilecek asit-baz homeostazı için destekleyici besinsel takviyelerin kullanılması (sodyum bikarbonat, sodyum sitrat, beta alanin vb.) sportif performansın optimal biçimde sürdürülebilmesi, oluşabilecek yorgunluğun geciktirilebilmesi ve performansın artırılması için tavsiye edilen alternatiflerdir.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":97824795,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97824795/thumbnails/1.jpg","file_name":"Gencoglu_C._et_al._Egzersizde_Asit_Baz_Homeostazi_Bir_Geleneksel_Derleme_Ulusal_Spor_Bilimleri_Dergisi_2022.pdf","download_url":"https://www.academia.edu/attachments/97824795/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Ulusal_Spor_Bilimleri_Dergisi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97824795/Gencoglu_C._et_al._Egzersizde_Asit_Baz_Homeostazi_Bir_Geleneksel_Derleme_Ulusal_Spor_Bilimleri_Dergisi_2022-libre.pdf?1674731356=\u0026response-content-disposition=attachment%3B+filename%3DUlusal_Spor_Bilimleri_Dergisi.pdf\u0026Expires=1734541248\u0026Signature=G22S-3mNS7ZxM~UI845hx~CjLw93BV-RMNRY3wTedIVKjmqgBEhSU2N7hxvNpxjJHrrM8J~TpjZxcAmg9xSfGKkGaa8nL35q4pSjI2V43RDacg2aFknhfx9IoBrJkIhv21b5QeWmj8Kuu5d9l3flqplaYKdJWQbToKrQDVy~bnGMX-ELqtdj3Sab4~rF7NF1mBp2qecduslgDtyy2eo2k4fS-OdMy2h9ohxSy7ACqLeKrrpwEvrcJEX-A6hGfbh5iLTZoL6LyeXOqt2O6dXCEO1bp8wrBYVp6pT5rliWUVEwVIHEa6giL~V~tYbvVnLYN4uRUxNjO08ez2BpBKRy3Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539837"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539837/Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles"><img alt="Research paper thumbnail of Increased Susceptibility to Apoptosis and Growth Arrest of Human Breast Cancer Cells Treated by a Snake Venom-Loaded Silica Nanoparticles" class="work-thumbnail" src="https://attachments.academia-assets.com/93326910/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539837/Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles">Increased Susceptibility to Apoptosis and Growth Arrest of Human Breast Cancer Cells Treated by a Snake Venom-Loaded Silica Nanoparticles</a></div><div class="wp-workCard_item"><span>Cellular Physiology and Biochemistry</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (<a href="http://www.karger.com/OA-license" rel="nofollow">www.karger.com/OA-license</a>), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="56695fd4ce5f452f5cc725a284bc39a0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326910,"asset_id":89539837,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326910/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539837"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539837"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539837; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539837]").text(description); $(".js-view-count[data-work-id=89539837]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539837; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539837']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539837, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "56695fd4ce5f452f5cc725a284bc39a0" } } $('.js-work-strip[data-work-id=89539837]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539837,"title":"Increased Susceptibility to Apoptosis and Growth Arrest of Human Breast Cancer Cells Treated by a Snake Venom-Loaded Silica Nanoparticles","translated_title":"","metadata":{"publisher":"S. Karger AG","ai_title_tag":"Snake Venom-Loaded Silica Nanoparticles Induce Breast Cancer Cell Death","grobid_abstract":"This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Cellular Physiology and Biochemistry","grobid_abstract_attachment_id":93326910},"translated_abstract":null,"internal_url":"https://www.academia.edu/89539837/Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles","translated_internal_url":"","created_at":"2022-10-30T09:48:20.758-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326910,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326910/thumbnails/1.jpg","file_name":"366366.pdf","download_url":"https://www.academia.edu/attachments/93326910/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Increased_Susceptibility_to_Apoptosis_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326910/366366-libre.pdf?1667150906=\u0026response-content-disposition=attachment%3B+filename%3DIncreased_Susceptibility_to_Apoptosis_an.pdf\u0026Expires=1734541249\u0026Signature=grjC4zM90Yq6cgtdqTrWkRYyePo8FU2dz6f4uhd4YWb4qNGUgiyIoofYO1bDSRF2p05grreRcuOQQ63aun3-naJwprGFtkJb2xoV86uzJB82LHqtVWBeh1FH8oeGhJYRY9xU5j6aWrHMIXFLYnpV7UITJZ3vY7SS8Qn9B2dTKj~HV7e9PHhbpWj~jDZ4HRDP0Umn-7wBmvvb51a84sqdWo9qaPQl6MT4xQPiYZ83sKPxzveA1nkVN45NYdc5NY~9FdU1mUCPjxROLhQXDV2UWJj7n~S0N6dONJ8ANN0nryhpEXwAy-RUb85btxdmExZtM8QSPPY8WeHMU0HZVLX5rQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles","translated_slug":"","page_count":12,"language":"en","content_type":"Work","summary":"This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326910,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326910/thumbnails/1.jpg","file_name":"366366.pdf","download_url":"https://www.academia.edu/attachments/93326910/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Increased_Susceptibility_to_Apoptosis_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326910/366366-libre.pdf?1667150906=\u0026response-content-disposition=attachment%3B+filename%3DIncreased_Susceptibility_to_Apoptosis_an.pdf\u0026Expires=1734541249\u0026Signature=grjC4zM90Yq6cgtdqTrWkRYyePo8FU2dz6f4uhd4YWb4qNGUgiyIoofYO1bDSRF2p05grreRcuOQQ63aun3-naJwprGFtkJb2xoV86uzJB82LHqtVWBeh1FH8oeGhJYRY9xU5j6aWrHMIXFLYnpV7UITJZ3vY7SS8Qn9B2dTKj~HV7e9PHhbpWj~jDZ4HRDP0Umn-7wBmvvb51a84sqdWo9qaPQl6MT4xQPiYZ83sKPxzveA1nkVN45NYdc5NY~9FdU1mUCPjxROLhQXDV2UWJj7n~S0N6dONJ8ANN0nryhpEXwAy-RUb85btxdmExZtM8QSPPY8WeHMU0HZVLX5rQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":25315059,"url":"https://www.karger.com/Article/Pdf/366366"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539257"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539257/Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds"><img alt="Research paper thumbnail of Synthesis and Cytotoxicity of Novel 3-Aryl-1-(3′-dibenzylaminomethyl-4′-hydroxyphenyl)-propenones and Related Compounds" class="work-thumbnail" src="https://attachments.academia-assets.com/93326471/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539257/Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds">Synthesis and Cytotoxicity of Novel 3-Aryl-1-(3′-dibenzylaminomethyl-4′-hydroxyphenyl)-propenones and Related Compounds</a></div><div class="wp-workCard_item"><span>CHEMICAL &amp; PHARMACEUTICAL BULLETIN</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to the formation of a novel series of 4-hydroxy-3-dibenzylaminomethyl chalcones (7a-e) instead of 4-hydroxy-3,5bis-(dibenzylaminomethyl)chalcones 4. In order to rationalise the formation of monoadduct 7, energy minimized model structures of 4a and 7a were compared. The in vitro cytotoxic activities of 7a-e were tested against PC-3 cell lines for the first time in this study and compared with the precursor 4-hydroxychalcones (1a-e). Except for compound 7a (IC 50 : 19.85 m mM), insertion of dibenzylaminomethyl function into 4-hydroxychalcones resulted in complete loss of cytotoxic activity. The results suggested that it is not only the pK a but also the shape and size of the amine that is critical in governing the cytotoxic activity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ebd02786c28d173e60a596cffaee578f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326471,"asset_id":89539257,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326471/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539257"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539257"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539257; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539257]").text(description); $(".js-view-count[data-work-id=89539257]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539257; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539257']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539257, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ebd02786c28d173e60a596cffaee578f" } } $('.js-work-strip[data-work-id=89539257]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539257,"title":"Synthesis and Cytotoxicity of Novel 3-Aryl-1-(3′-dibenzylaminomethyl-4′-hydroxyphenyl)-propenones and Related Compounds","translated_title":"","metadata":{"publisher":"Pharmaceutical Society of Japan","grobid_abstract":"The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to the formation of a novel series of 4-hydroxy-3-dibenzylaminomethyl chalcones (7a-e) instead of 4-hydroxy-3,5bis-(dibenzylaminomethyl)chalcones 4. In order to rationalise the formation of monoadduct 7, energy minimized model structures of 4a and 7a were compared. The in vitro cytotoxic activities of 7a-e were tested against PC-3 cell lines for the first time in this study and compared with the precursor 4-hydroxychalcones (1a-e). Except for compound 7a (IC 50 : 19.85 m mM), insertion of dibenzylaminomethyl function into 4-hydroxychalcones resulted in complete loss of cytotoxic activity. The results suggested that it is not only the pK a but also the shape and size of the amine that is critical in governing the cytotoxic activity.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"CHEMICAL \u0026amp; PHARMACEUTICAL BULLETIN","grobid_abstract_attachment_id":93326471},"translated_abstract":null,"internal_url":"https://www.academia.edu/89539257/Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds","translated_internal_url":"","created_at":"2022-10-30T09:38:58.928-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326471,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326471/thumbnails/1.jpg","file_name":"_pdf.pdf","download_url":"https://www.academia.edu/attachments/93326471/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Synthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326471/_pdf-libre.pdf?1667150915=\u0026response-content-disposition=attachment%3B+filename%3DSynthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf\u0026Expires=1734541249\u0026Signature=ctwiLfDG7W2xSSPCPmejZEUoUWRKkOZRn0Ku4x~7Q3CZmDRVHW6GY6g3cBLFGSBFNpRjKakZQJrG4XR5Z5YIYwOkoOV9dPmY6dUPKEezQ-XZg9Ve-8eCb68YOeWt286FjlayiQ21jH0hZbkSfBEfrZxh-fVx4~j76GBJRbFX3swCf4FEOEU~6dxh6LL-Ow3x-3AgE4ynrygNr-1Oor8aowYOgbCk0aHtfylxMRNVWnIAwF1lqCqQBAOQDsMX5iY0m-gmg~X-VxVbbEnV6g3N~QSOtMlcAU~Bqn9j3GKcuIOtFs--5kyGJu68eYf80iH9oRHY4uxDtggVzrBppWbnKg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds","translated_slug":"","page_count":7,"language":"en","content_type":"Work","summary":"The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to the formation of a novel series of 4-hydroxy-3-dibenzylaminomethyl chalcones (7a-e) instead of 4-hydroxy-3,5bis-(dibenzylaminomethyl)chalcones 4. In order to rationalise the formation of monoadduct 7, energy minimized model structures of 4a and 7a were compared. The in vitro cytotoxic activities of 7a-e were tested against PC-3 cell lines for the first time in this study and compared with the precursor 4-hydroxychalcones (1a-e). Except for compound 7a (IC 50 : 19.85 m mM), insertion of dibenzylaminomethyl function into 4-hydroxychalcones resulted in complete loss of cytotoxic activity. The results suggested that it is not only the pK a but also the shape and size of the amine that is critical in governing the cytotoxic activity.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326471,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326471/thumbnails/1.jpg","file_name":"_pdf.pdf","download_url":"https://www.academia.edu/attachments/93326471/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Synthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326471/_pdf-libre.pdf?1667150915=\u0026response-content-disposition=attachment%3B+filename%3DSynthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf\u0026Expires=1734541249\u0026Signature=ctwiLfDG7W2xSSPCPmejZEUoUWRKkOZRn0Ku4x~7Q3CZmDRVHW6GY6g3cBLFGSBFNpRjKakZQJrG4XR5Z5YIYwOkoOV9dPmY6dUPKEezQ-XZg9Ve-8eCb68YOeWt286FjlayiQ21jH0hZbkSfBEfrZxh-fVx4~j76GBJRbFX3swCf4FEOEU~6dxh6LL-Ow3x-3AgE4ynrygNr-1Oor8aowYOgbCk0aHtfylxMRNVWnIAwF1lqCqQBAOQDsMX5iY0m-gmg~X-VxVbbEnV6g3N~QSOtMlcAU~Bqn9j3GKcuIOtFs--5kyGJu68eYf80iH9oRHY4uxDtggVzrBppWbnKg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":12597,"name":"Crystallization","url":"https://www.academia.edu/Documents/in/Crystallization"},{"id":14054,"name":"Chemical","url":"https://www.academia.edu/Documents/in/Chemical"},{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy"},{"id":22050,"name":"Cytotoxicity","url":"https://www.academia.edu/Documents/in/Cytotoxicity"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":114715,"name":"Stereochemistry","url":"https://www.academia.edu/Documents/in/Stereochemistry"},{"id":184989,"name":"Carcinogens","url":"https://www.academia.edu/Documents/in/Carcinogens"},{"id":309949,"name":"Propane","url":"https://www.academia.edu/Documents/in/Propane"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":1162913,"name":"Mutagens","url":"https://www.academia.edu/Documents/in/Mutagens"},{"id":1271583,"name":"Aryl","url":"https://www.academia.edu/Documents/in/Aryl"},{"id":2898895,"name":"binding sites","url":"https://www.academia.edu/Documents/in/binding_sites"},{"id":3024741,"name":"ketones","url":"https://www.academia.edu/Documents/in/ketones"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":25314789,"url":"https://www.jstage.jst.go.jp/article/cpb/56/12/56_12_1675/_pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539210"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539210/Sorafenib_alleviates_inflammatory_signaling_of_tumor_microenvironment_in_lung_cancer"><img alt="Research paper thumbnail of Sorafenib alleviates inflammatory signaling of tumor microenvironment in lung cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/93326348/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539210/Sorafenib_alleviates_inflammatory_signaling_of_tumor_microenvironment_in_lung_cancer">Sorafenib alleviates inflammatory signaling of tumor microenvironment in lung cancer</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: This study was designed to assess the possible beneficial effects of sorafenib (SOR) ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: This study was designed to assess the possible beneficial effects of sorafenib (SOR) in diethylnitrosamine (DEN) induced lung carcinogenesis in male rats and also to examine its probable mechanisms of action. Methods and results: A total of 30 adult male rats were divided into three groups as (1) control, (2) DEN, and (3) DEN+SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum samples were analyzed to determine SOX2 levels. Levels of SOX2, TNF-α and IL-1β were measured in lung tissue supernatants. Lung sections were evaluated histopathologically. Also, COX-2 and JNK were analyzed by immunohistochemistry and immunofluorescence methods respectively. SOR reduced the level of SOX2 that maintenance of cancer stemness and tumorigenicity, and TNF-α and IL-1β levels. Furthermore, SOR ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="994abb0b02db94effb8c0310b9d4af22" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326348,"asset_id":89539210,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326348/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539210"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539210"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539210; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539210]").text(description); $(".js-view-count[data-work-id=89539210]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539210; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539210']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539210, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "994abb0b02db94effb8c0310b9d4af22" } } $('.js-work-strip[data-work-id=89539210]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539210,"title":"Sorafenib alleviates inflammatory signaling of tumor microenvironment in lung cancer","translated_title":"","metadata":{"abstract":"Background: This study was designed to assess the possible beneficial effects of sorafenib (SOR) in diethylnitrosamine (DEN) induced lung carcinogenesis in male rats and also to examine its probable mechanisms of action. Methods and results: A total of 30 adult male rats were divided into three groups as (1) control, (2) DEN, and (3) DEN+SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum samples were analyzed to determine SOX2 levels. Levels of SOX2, TNF-α and IL-1β were measured in lung tissue supernatants. Lung sections were evaluated histopathologically. Also, COX-2 and JNK were analyzed by immunohistochemistry and immunofluorescence methods respectively. SOR reduced the level of SOX2 that maintenance of cancer stemness and tumorigenicity, and TNF-α and IL-1β levels. Furthermore, SOR ...","publisher":"Research Square Platform LLC"},"translated_abstract":"Background: This study was designed to assess the possible beneficial effects of sorafenib (SOR) in diethylnitrosamine (DEN) induced lung carcinogenesis in male rats and also to examine its probable mechanisms of action. Methods and results: A total of 30 adult male rats were divided into three groups as (1) control, (2) DEN, and (3) DEN+SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum samples were analyzed to determine SOX2 levels. Levels of SOX2, TNF-α and IL-1β were measured in lung tissue supernatants. Lung sections were evaluated histopathologically. Also, COX-2 and JNK were analyzed by immunohistochemistry and immunofluorescence methods respectively. SOR reduced the level of SOX2 that maintenance of cancer stemness and tumorigenicity, and TNF-α and IL-1β levels. Furthermore, SOR ...","internal_url":"https://www.academia.edu/89539210/Sorafenib_alleviates_inflammatory_signaling_of_tumor_microenvironment_in_lung_cancer","translated_internal_url":"","created_at":"2022-10-30T09:38:05.193-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326348,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326348/thumbnails/1.jpg","file_name":"latest.pdf","download_url":"https://www.academia.edu/attachments/93326348/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Sorafenib_alleviates_inflammatory_signal.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326348/latest-libre.pdf?1667150937=\u0026response-content-disposition=attachment%3B+filename%3DSorafenib_alleviates_inflammatory_signal.pdf\u0026Expires=1734541249\u0026Signature=ATq4ezArU11bAU6e0TmsgKSGeVeHNMfLcjLlQJi4NTupCZ9gEueV5~Bs7K1iU7BGtsbSj10qv2mGlEce22dbdWaeQSrJ0tCyyx7lb8o4VN0J7rVodIiwUJW7oniCLDGwXUPkrHQK8LjNv6FMTjW8vm1-hXXaJ5KH~Qheb9RpbKOB1z489oKLaeN77ufTYQBtdZaJNlFlqT2FL0VYbjnube24x7gsZidXOWW58rqLqXcxAuf0snVeCt6uqv0VWE1vhkw1gJzxbAk8CUMATsnVUpmQS~wYiguz9BY4t2RD7mFzR92IrmgEc8nCnppIZ3oQiRPi23it3xF3pcrqPEg6Og__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Sorafenib_alleviates_inflammatory_signaling_of_tumor_microenvironment_in_lung_cancer","translated_slug":"","page_count":14,"language":"en","content_type":"Work","summary":"Background: This study was designed to assess the possible beneficial effects of sorafenib (SOR) in diethylnitrosamine (DEN) induced lung carcinogenesis in male rats and also to examine its probable mechanisms of action. Methods and results: A total of 30 adult male rats were divided into three groups as (1) control, (2) DEN, and (3) DEN+SOR. The chemical induction of lung carcinogenesis was performed by injection of DEN intraperitoneally at 150 mg/kg once a week for two weeks. The DEN-administered rats were co-treated with SOR of 10 mg/kg by oral gavage for 42 alternate days. Serum samples were analyzed to determine SOX2 levels. Levels of SOX2, TNF-α and IL-1β were measured in lung tissue supernatants. Lung sections were evaluated histopathologically. Also, COX-2 and JNK were analyzed by immunohistochemistry and immunofluorescence methods respectively. SOR reduced the level of SOX2 that maintenance of cancer stemness and tumorigenicity, and TNF-α and IL-1β levels. Furthermore, SOR ...","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326348,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326348/thumbnails/1.jpg","file_name":"latest.pdf","download_url":"https://www.academia.edu/attachments/93326348/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Sorafenib_alleviates_inflammatory_signal.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326348/latest-libre.pdf?1667150937=\u0026response-content-disposition=attachment%3B+filename%3DSorafenib_alleviates_inflammatory_signal.pdf\u0026Expires=1734541249\u0026Signature=ATq4ezArU11bAU6e0TmsgKSGeVeHNMfLcjLlQJi4NTupCZ9gEueV5~Bs7K1iU7BGtsbSj10qv2mGlEce22dbdWaeQSrJ0tCyyx7lb8o4VN0J7rVodIiwUJW7oniCLDGwXUPkrHQK8LjNv6FMTjW8vm1-hXXaJ5KH~Qheb9RpbKOB1z489oKLaeN77ufTYQBtdZaJNlFlqT2FL0VYbjnube24x7gsZidXOWW58rqLqXcxAuf0snVeCt6uqv0VWE1vhkw1gJzxbAk8CUMATsnVUpmQS~wYiguz9BY4t2RD7mFzR92IrmgEc8nCnppIZ3oQiRPi23it3xF3pcrqPEg6Og__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51698,"name":"Lung Cancer","url":"https://www.academia.edu/Documents/in/Lung_Cancer"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung"},{"id":340262,"name":"Carcinogenesis","url":"https://www.academia.edu/Documents/in/Carcinogenesis"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha"},{"id":1003057,"name":"Sorafenib","url":"https://www.academia.edu/Documents/in/Sorafenib"},{"id":1137385,"name":"Sox","url":"https://www.academia.edu/Documents/in/Sox"}],"urls":[{"id":25314614,"url":"https://www.researchsquare.com/article/rs-1219452/v2"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539208"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539208/Monoamine_Oxidase_MAO_as_a_Potential_Target_for_Anticancer_Drug_Design_and_Development"><img alt="Research paper thumbnail of Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development" class="work-thumbnail" src="https://attachments.academia-assets.com/93326285/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539208/Monoamine_Oxidase_MAO_as_a_Potential_Target_for_Anticancer_Drug_Design_and_Development">Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development</a></div><div class="wp-workCard_item"><span>Molecules</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination. Owing to the crucial role of MAOs in maintaining functional levels of neurotransmitters, the implications of its distorted activity have been associated with numerous neurological diseases. Recently, an unanticipated role of MAOs in tumor progression and metastasis has been reported. The chemical inhibition of MAOs might be a valuable therapeutic approach for cancer treatment. In this review, we reported computational approaches exploited in the design and development of selective MAO inhibitors accompanied by their biological activities. Additionally, we generated a pharmacophore model for MAO-A active inhibitors to identify the structural motifs to invoke an activity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a087fbca926c4f5eb0eec1b626c1acb0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326285,"asset_id":89539208,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326285/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539208"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539208"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539208; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539208]").text(description); $(".js-view-count[data-work-id=89539208]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539208; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539208']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539208, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a087fbca926c4f5eb0eec1b626c1acb0" } } $('.js-work-strip[data-work-id=89539208]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539208,"title":"Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development","translated_title":"","metadata":{"abstract":"Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination. Owing to the crucial role of MAOs in maintaining functional levels of neurotransmitters, the implications of its distorted activity have been associated with numerous neurological diseases. Recently, an unanticipated role of MAOs in tumor progression and metastasis has been reported. The chemical inhibition of MAOs might be a valuable therapeutic approach for cancer treatment. In this review, we reported computational approaches exploited in the design and development of selective MAO inhibitors accompanied by their biological activities. Additionally, we generated a pharmacophore model for MAO-A active inhibitors to identify the structural motifs to invoke an activity.","publisher":"MDPI AG","ai_title_tag":"MAO Inhibitors: A New Frontier in Anticancer Drug Design","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Molecules"},"translated_abstract":"Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination. Owing to the crucial role of MAOs in maintaining functional levels of neurotransmitters, the implications of its distorted activity have been associated with numerous neurological diseases. Recently, an unanticipated role of MAOs in tumor progression and metastasis has been reported. The chemical inhibition of MAOs might be a valuable therapeutic approach for cancer treatment. In this review, we reported computational approaches exploited in the design and development of selective MAO inhibitors accompanied by their biological activities. Additionally, we generated a pharmacophore model for MAO-A active inhibitors to identify the structural motifs to invoke an activity.","internal_url":"https://www.academia.edu/89539208/Monoamine_Oxidase_MAO_as_a_Potential_Target_for_Anticancer_Drug_Design_and_Development","translated_internal_url":"","created_at":"2022-10-30T09:38:05.060-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326285,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326285/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/93326285/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Monoamine_Oxidase_MAO_as_a_Potential_Tar.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326285/pdf-libre.pdf?1667150953=\u0026response-content-disposition=attachment%3B+filename%3DMonoamine_Oxidase_MAO_as_a_Potential_Tar.pdf\u0026Expires=1734541249\u0026Signature=hDvMmm0FzBN47BEJE824hF~fKZMVbiTBkfv8~4EKPE0TegJ9YCq16klSClYYeMzCRC0eyRBLbcQi1wYw~xxt6NsDz~T75rUksJ5wNJbLXQuboRKj5y3wPBjFb4t7JLBy2lvNgkjMePpu0upIcr2d3OlZeGuNilDnCB3GkgT44Z4ymscxhH2J-fjkY36Mhk-OZstM0CYYuMiE6MWyYdqtQud6TeVE2axzNB3yBA-qrv50jopieni3r5KMSd6XV4JcOQdtc~ERbVaHZlSj0NY6Mkv82kYvZ5kVcIvdnvDQgMB6cfMjaQrZCdMa8awM5JWhNN33wlB9118vZBWKKnJrBw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Monoamine_Oxidase_MAO_as_a_Potential_Target_for_Anticancer_Drug_Design_and_Development","translated_slug":"","page_count":19,"language":"en","content_type":"Work","summary":"Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination. Owing to the crucial role of MAOs in maintaining functional levels of neurotransmitters, the implications of its distorted activity have been associated with numerous neurological diseases. Recently, an unanticipated role of MAOs in tumor progression and metastasis has been reported. The chemical inhibition of MAOs might be a valuable therapeutic approach for cancer treatment. In this review, we reported computational approaches exploited in the design and development of selective MAO inhibitors accompanied by their biological activities. Additionally, we generated a pharmacophore model for MAO-A active inhibitors to identify the structural motifs to invoke an activity.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326285,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326285/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/93326285/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Monoamine_Oxidase_MAO_as_a_Potential_Tar.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326285/pdf-libre.pdf?1667150953=\u0026response-content-disposition=attachment%3B+filename%3DMonoamine_Oxidase_MAO_as_a_Potential_Tar.pdf\u0026Expires=1734541249\u0026Signature=hDvMmm0FzBN47BEJE824hF~fKZMVbiTBkfv8~4EKPE0TegJ9YCq16klSClYYeMzCRC0eyRBLbcQi1wYw~xxt6NsDz~T75rUksJ5wNJbLXQuboRKj5y3wPBjFb4t7JLBy2lvNgkjMePpu0upIcr2d3OlZeGuNilDnCB3GkgT44Z4ymscxhH2J-fjkY36Mhk-OZstM0CYYuMiE6MWyYdqtQud6TeVE2axzNB3yBA-qrv50jopieni3r5KMSd6XV4JcOQdtc~ERbVaHZlSj0NY6Mkv82kYvZ5kVcIvdnvDQgMB6cfMjaQrZCdMa8awM5JWhNN33wlB9118vZBWKKnJrBw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":328449,"name":"Molecules","url":"https://www.academia.edu/Documents/in/Molecules"},{"id":350932,"name":"Oxidative Deamination","url":"https://www.academia.edu/Documents/in/Oxidative_Deamination"},{"id":1243420,"name":"Monoamine oxidase","url":"https://www.academia.edu/Documents/in/Monoamine_oxidase"},{"id":1337586,"name":"Pharmacophore","url":"https://www.academia.edu/Documents/in/Pharmacophore"}],"urls":[{"id":25314612,"url":"https://www.mdpi.com/1420-3049/26/19/6019/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539206"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539206/Is_Oxytocin_Proper_for_Cancer_Adjuvant_Therapy"><img alt="Research paper thumbnail of Is Oxytocin Proper for Cancer Adjuvant Therapy?" class="work-thumbnail" src="https://attachments.academia-assets.com/93326284/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539206/Is_Oxytocin_Proper_for_Cancer_Adjuvant_Therapy">Is Oxytocin Proper for Cancer Adjuvant Therapy?</a></div><div class="wp-workCard_item"><span>Proceedings</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Neuroblastomas are solid tumors and mostly seen in the adrenal medulla and sympathetic ganglia. I...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Neuroblastomas are solid tumors and mostly seen in the adrenal medulla and sympathetic ganglia. It is known that neuroblastoma cell proliferation is inhibited by cisplatin and vincristine. The aim of this study was to investigate the effect of oxytocin on cell viability in human neuroblastoma SH-SY5Y cell line and primary cerebral cortex cell culture exposed to cisplatin and vincristine. In this direction, SH-SY5Y cell line and cortex neurons were obtained from the medical pharmacology department, Ataturk University. Both cells were grown in the appropriate cell culture media. Cisplatin (5, 10, 15 μg), vincristine (0.5, 1 and 2 ng) and oxytocin (1 μM) were applied to SH-SY5Y cell line and primary cortex cell culture for 24 h. MTT and TAC-TOS tests were performed 24 h after the application. As a result of the MTT assay, the combination of cisplatin and vincristine reduced cell viability in both cultures approximately 25% and 22%, respectively, compared to the control group. It appear...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9cae56ffddcd0edf9720a2830fd17774" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326284,"asset_id":89539206,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326284/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539206"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539206"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539206; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539206]").text(description); $(".js-view-count[data-work-id=89539206]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539206; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539206']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539206, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9cae56ffddcd0edf9720a2830fd17774" } } $('.js-work-strip[data-work-id=89539206]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539206,"title":"Is Oxytocin Proper for Cancer Adjuvant Therapy?","translated_title":"","metadata":{"abstract":"Neuroblastomas are solid tumors and mostly seen in the adrenal medulla and sympathetic ganglia. It is known that neuroblastoma cell proliferation is inhibited by cisplatin and vincristine. The aim of this study was to investigate the effect of oxytocin on cell viability in human neuroblastoma SH-SY5Y cell line and primary cerebral cortex cell culture exposed to cisplatin and vincristine. In this direction, SH-SY5Y cell line and cortex neurons were obtained from the medical pharmacology department, Ataturk University. Both cells were grown in the appropriate cell culture media. Cisplatin (5, 10, 15 μg), vincristine (0.5, 1 and 2 ng) and oxytocin (1 μM) were applied to SH-SY5Y cell line and primary cortex cell culture for 24 h. MTT and TAC-TOS tests were performed 24 h after the application. As a result of the MTT assay, the combination of cisplatin and vincristine reduced cell viability in both cultures approximately 25% and 22%, respectively, compared to the control group. It appear...","publisher":"MDPI AG","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Proceedings"},"translated_abstract":"Neuroblastomas are solid tumors and mostly seen in the adrenal medulla and sympathetic ganglia. It is known that neuroblastoma cell proliferation is inhibited by cisplatin and vincristine. The aim of this study was to investigate the effect of oxytocin on cell viability in human neuroblastoma SH-SY5Y cell line and primary cerebral cortex cell culture exposed to cisplatin and vincristine. In this direction, SH-SY5Y cell line and cortex neurons were obtained from the medical pharmacology department, Ataturk University. Both cells were grown in the appropriate cell culture media. Cisplatin (5, 10, 15 μg), vincristine (0.5, 1 and 2 ng) and oxytocin (1 μM) were applied to SH-SY5Y cell line and primary cortex cell culture for 24 h. MTT and TAC-TOS tests were performed 24 h after the application. As a result of the MTT assay, the combination of cisplatin and vincristine reduced cell viability in both cultures approximately 25% and 22%, respectively, compared to the control group. It appear...","internal_url":"https://www.academia.edu/89539206/Is_Oxytocin_Proper_for_Cancer_Adjuvant_Therapy","translated_internal_url":"","created_at":"2022-10-30T09:38:04.936-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326284,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326284/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/93326284/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Is_Oxytocin_Proper_for_Cancer_Adjuvant_T.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326284/pdf-libre.pdf?1667150947=\u0026response-content-disposition=attachment%3B+filename%3DIs_Oxytocin_Proper_for_Cancer_Adjuvant_T.pdf\u0026Expires=1734541249\u0026Signature=JCm1rBXZAh~8kL6EoFyRLazkm1XmYw4EzuUYxfsh35PJ42zT4VYHcDvjcHtkg0jJ1MlsY3iRZDJiGTA5IlWy7elNfcLl7MAOn-XnXYaVw-On9LLJ3QSHutBUSxPjXOFb1OG~QVEX0amY2ZknJKIU8ECw6Kl237aTP3tu7q93lvWUhhmbMQnJwowTk~npZ3BhY7ZqpFViIrNq~BPB9OARBJqnULYsxnBP0HKqEWt8O854s-x-h2E7nVHHb93suOxeZcuNBPSOkvZEGHC-6fD0BDchYIsP2WG9XUaGjSKNUy2FdIFSqwgAutItSgGD52ggPTTpK3FAxBYOVBr5mOPPEQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Is_Oxytocin_Proper_for_Cancer_Adjuvant_Therapy","translated_slug":"","page_count":4,"language":"en","content_type":"Work","summary":"Neuroblastomas are solid tumors and mostly seen in the adrenal medulla and sympathetic ganglia. It is known that neuroblastoma cell proliferation is inhibited by cisplatin and vincristine. The aim of this study was to investigate the effect of oxytocin on cell viability in human neuroblastoma SH-SY5Y cell line and primary cerebral cortex cell culture exposed to cisplatin and vincristine. In this direction, SH-SY5Y cell line and cortex neurons were obtained from the medical pharmacology department, Ataturk University. Both cells were grown in the appropriate cell culture media. Cisplatin (5, 10, 15 μg), vincristine (0.5, 1 and 2 ng) and oxytocin (1 μM) were applied to SH-SY5Y cell line and primary cortex cell culture for 24 h. MTT and TAC-TOS tests were performed 24 h after the application. As a result of the MTT assay, the combination of cisplatin and vincristine reduced cell viability in both cultures approximately 25% and 22%, respectively, compared to the control group. It appear...","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326284,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326284/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/93326284/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Is_Oxytocin_Proper_for_Cancer_Adjuvant_T.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326284/pdf-libre.pdf?1667150947=\u0026response-content-disposition=attachment%3B+filename%3DIs_Oxytocin_Proper_for_Cancer_Adjuvant_T.pdf\u0026Expires=1734541249\u0026Signature=JCm1rBXZAh~8kL6EoFyRLazkm1XmYw4EzuUYxfsh35PJ42zT4VYHcDvjcHtkg0jJ1MlsY3iRZDJiGTA5IlWy7elNfcLl7MAOn-XnXYaVw-On9LLJ3QSHutBUSxPjXOFb1OG~QVEX0amY2ZknJKIU8ECw6Kl237aTP3tu7q93lvWUhhmbMQnJwowTk~npZ3BhY7ZqpFViIrNq~BPB9OARBJqnULYsxnBP0HKqEWt8O854s-x-h2E7nVHHb93suOxeZcuNBPSOkvZEGHC-6fD0BDchYIsP2WG9XUaGjSKNUy2FdIFSqwgAutItSgGD52ggPTTpK3FAxBYOVBr5mOPPEQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":93326283,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326283/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/93326283/download_file","bulk_download_file_name":"Is_Oxytocin_Proper_for_Cancer_Adjuvant_T.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326283/pdf-libre.pdf?1667150949=\u0026response-content-disposition=attachment%3B+filename%3DIs_Oxytocin_Proper_for_Cancer_Adjuvant_T.pdf\u0026Expires=1734541249\u0026Signature=SMy7yVYOlcs4oBDZre8Plg8lQoPhYXS-bLAly7h8jsA9SrD8dRrYvLRU-qrTFeaLTuwELsDYUiLIpgp3SxCnk7dQNhkkAvbHetzCsT59LlPFTs5oP9H2AXn5O-xzkWIqiAnvOCrLb1ZYQYWFcMCm5hQG6E78SgWATNVTt69cxPzA2Hd9q7MclakNxPzB7Vkbua3gtlHwxyR48g5XLDfD9nGlyqKQ1pLJDbANvHsbu0-C232-fEBt9uD~pA9kkpdzbLxfto3dqQ4Crh7K4l8u4CP~1jCVsG7EHd2-syY9tbpg2JHUTTPjEtvhXecZp-7Hc5EXc-PPQb2i~Zko8fzNLg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":40276,"name":"Proceedings","url":"https://www.academia.edu/Documents/in/Proceedings"},{"id":53735,"name":"Oxytocin","url":"https://www.academia.edu/Documents/in/Oxytocin"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":1485245,"name":"Adjuvant","url":"https://www.academia.edu/Documents/in/Adjuvant"}],"urls":[{"id":25314610,"url":"http://www.mdpi.com/2504-3900/2/25/1582/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539205"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539205/The_Codes_of_Publication_Policy_of_the_Eurasian_Journal_of_Medicine_Parameters_for_a_Stable_and_Sustainable_Journal"><img alt="Research paper thumbnail of The Codes of Publication Policy of the Eurasian Journal of Medicine: Parameters for a Stable and Sustainable Journal" class="work-thumbnail" src="https://attachments.academia-assets.com/93326346/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539205/The_Codes_of_Publication_Policy_of_the_Eurasian_Journal_of_Medicine_Parameters_for_a_Stable_and_Sustainable_Journal">The Codes of Publication Policy of the Eurasian Journal of Medicine: Parameters for a Stable and Sustainable Journal</a></div><div class="wp-workCard_item"><span>The Eurasian Journal of Medicine</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7ef7aabecfadfb6d8fd34d559038a862" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326346,"asset_id":89539205,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326346/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539205"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539205"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539205; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539205]").text(description); $(".js-view-count[data-work-id=89539205]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539205; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539205']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539205, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7ef7aabecfadfb6d8fd34d559038a862" } } $('.js-work-strip[data-work-id=89539205]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539205,"title":"The Codes of Publication Policy of the Eurasian Journal of Medicine: Parameters for a Stable and Sustainable Journal","translated_title":"","metadata":{"publisher":"AVES Publishing Co.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"The Eurasian Journal of Medicine"},"translated_abstract":null,"internal_url":"https://www.academia.edu/89539205/The_Codes_of_Publication_Policy_of_the_Eurasian_Journal_of_Medicine_Parameters_for_a_Stable_and_Sustainable_Journal","translated_internal_url":"","created_at":"2022-10-30T09:38:04.842-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326346,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326346/thumbnails/1.jpg","file_name":"e80333989cbf5e07c6015e1236ebd1cc65fd.pdf","download_url":"https://www.academia.edu/attachments/93326346/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Codes_of_Publication_Policy_of_the_E.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326346/e80333989cbf5e07c6015e1236ebd1cc65fd-libre.pdf?1667150928=\u0026response-content-disposition=attachment%3B+filename%3DThe_Codes_of_Publication_Policy_of_the_E.pdf\u0026Expires=1734541249\u0026Signature=A78KFDu0v7zR4JAW~ADmsLfFohI-XnDb3DDxg74KY9cdPUVeE~OoxLIWsDVCKPR6VSik~zf2yvu2yTctMXg3F0b3vJEZtLXXgadpQA8OFeTxVqrSBvObagHrJrMDkvif~iFPrUoU6KVaNZ1GkiwhfEOq08jSGvN2C-GZ9BpuClKjlMGzuxdL~m0R7luiwnYBFRQh5mOmQDaT9oflSpHmXqik8et17HRIVFvwM~g~hnSD8arxzfTMGBhhqwz-IB0zKDKBKOqNy~h8Sn2~D4BVGGLsa7BzgakjvB8Zo-fRwYmrtxa-2cGTgEkeirG8tjVerjPjr4~J3hdNYK-MVxdYWg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Codes_of_Publication_Policy_of_the_Eurasian_Journal_of_Medicine_Parameters_for_a_Stable_and_Sustainable_Journal","translated_slug":"","page_count":1,"language":"en","content_type":"Work","summary":null,"owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326346,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326346/thumbnails/1.jpg","file_name":"e80333989cbf5e07c6015e1236ebd1cc65fd.pdf","download_url":"https://www.academia.edu/attachments/93326346/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Codes_of_Publication_Policy_of_the_E.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326346/e80333989cbf5e07c6015e1236ebd1cc65fd-libre.pdf?1667150928=\u0026response-content-disposition=attachment%3B+filename%3DThe_Codes_of_Publication_Policy_of_the_E.pdf\u0026Expires=1734541249\u0026Signature=A78KFDu0v7zR4JAW~ADmsLfFohI-XnDb3DDxg74KY9cdPUVeE~OoxLIWsDVCKPR6VSik~zf2yvu2yTctMXg3F0b3vJEZtLXXgadpQA8OFeTxVqrSBvObagHrJrMDkvif~iFPrUoU6KVaNZ1GkiwhfEOq08jSGvN2C-GZ9BpuClKjlMGzuxdL~m0R7luiwnYBFRQh5mOmQDaT9oflSpHmXqik8et17HRIVFvwM~g~hnSD8arxzfTMGBhhqwz-IB0zKDKBKOqNy~h8Sn2~D4BVGGLsa7BzgakjvB8Zo-fRwYmrtxa-2cGTgEkeirG8tjVerjPjr4~J3hdNYK-MVxdYWg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":111412,"name":"TURKISH","url":"https://www.academia.edu/Documents/in/TURKISH"},{"id":199319,"name":"Citation","url":"https://www.academia.edu/Documents/in/Citation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539203"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539203/Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles"><img alt="Research paper thumbnail of Increased Susceptibility to Apoptosis and Growth Arrest of Human Breast Cancer Cells Treated by a Snake Venom-Loaded Silica Nanoparticles" class="work-thumbnail" src="https://attachments.academia-assets.com/93326282/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539203/Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles">Increased Susceptibility to Apoptosis and Growth Arrest of Human Breast Cancer Cells Treated by a Snake Venom-Loaded Silica Nanoparticles</a></div><div class="wp-workCard_item"><span>Cellular Physiology and Biochemistry</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (<a href="http://www.karger.com/OA-license" rel="nofollow">www.karger.com/OA-license</a>), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a4d22124c109a2cabbcb4296a9cab84d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326282,"asset_id":89539203,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326282/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539203"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539203"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539203; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539203]").text(description); $(".js-view-count[data-work-id=89539203]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539203; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539203']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539203, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a4d22124c109a2cabbcb4296a9cab84d" } } $('.js-work-strip[data-work-id=89539203]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539203,"title":"Increased Susceptibility to Apoptosis and Growth Arrest of Human Breast Cancer Cells Treated by a Snake Venom-Loaded Silica Nanoparticles","translated_title":"","metadata":{"publisher":"S. Karger AG","grobid_abstract":"This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Cellular Physiology and Biochemistry","grobid_abstract_attachment_id":93326282},"translated_abstract":null,"internal_url":"https://www.academia.edu/89539203/Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles","translated_internal_url":"","created_at":"2022-10-30T09:38:04.522-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326282,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326282/thumbnails/1.jpg","file_name":"366366.pdf","download_url":"https://www.academia.edu/attachments/93326282/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Increased_Susceptibility_to_Apoptosis_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326282/366366-libre.pdf?1667150948=\u0026response-content-disposition=attachment%3B+filename%3DIncreased_Susceptibility_to_Apoptosis_an.pdf\u0026Expires=1734541249\u0026Signature=Zy9EPJoZYhClLS~GteaW0L0fwmdyO~kUGtSwqunvA-EXFOckuESd1~R814Sz9S1nzT2yXHFEz0lsVTeuQTgjDoMsWyqlPlSde6Hgbu2hg9pcAncLA5XiWUaA72Dow37vh9EaAmagYLpp0PzzhWOZ0WHTuMXI3nKh1GmDYTl5RFaVBSr~r2rR0StZ2~tjwt5tfrXZFBpAk~C4N6HyLQ9ZRmKFINZfWDga7lHES79aBjAPUQz1F2d1aGmWNGuOQCavjQMOa~CVmS7fGvdmv7gGO6z-kjfR-yNlBcQA4XyN5kEFcB1~V6mwQxICC86y8faID3IF66fTWHMDGyO8sFHSCA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Increased_Susceptibility_to_Apoptosis_and_Growth_Arrest_of_Human_Breast_Cancer_Cells_Treated_by_a_Snake_Venom_Loaded_Silica_Nanoparticles","translated_slug":"","page_count":12,"language":"en","content_type":"Work","summary":"This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326282,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326282/thumbnails/1.jpg","file_name":"366366.pdf","download_url":"https://www.academia.edu/attachments/93326282/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Increased_Susceptibility_to_Apoptosis_an.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326282/366366-libre.pdf?1667150948=\u0026response-content-disposition=attachment%3B+filename%3DIncreased_Susceptibility_to_Apoptosis_an.pdf\u0026Expires=1734541249\u0026Signature=Zy9EPJoZYhClLS~GteaW0L0fwmdyO~kUGtSwqunvA-EXFOckuESd1~R814Sz9S1nzT2yXHFEz0lsVTeuQTgjDoMsWyqlPlSde6Hgbu2hg9pcAncLA5XiWUaA72Dow37vh9EaAmagYLpp0PzzhWOZ0WHTuMXI3nKh1GmDYTl5RFaVBSr~r2rR0StZ2~tjwt5tfrXZFBpAk~C4N6HyLQ9ZRmKFINZfWDga7lHES79aBjAPUQz1F2d1aGmWNGuOQCavjQMOa~CVmS7fGvdmv7gGO6z-kjfR-yNlBcQA4XyN5kEFcB1~V6mwQxICC86y8faID3IF66fTWHMDGyO8sFHSCA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer"},{"id":13621,"name":"Nanoparticles","url":"https://www.academia.edu/Documents/in/Nanoparticles"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":34713,"name":"Snake venoms","url":"https://www.academia.edu/Documents/in/Snake_venoms"},{"id":50841,"name":"Caspases","url":"https://www.academia.edu/Documents/in/Caspases"},{"id":82978,"name":"Reactive Oxygen Species","url":"https://www.academia.edu/Documents/in/Reactive_Oxygen_Species"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":506082,"name":"Cancer Cell","url":"https://www.academia.edu/Documents/in/Cancer_Cell"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":1031069,"name":"Silicon Dioxide","url":"https://www.academia.edu/Documents/in/Silicon_Dioxide"},{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms"}],"urls":[{"id":25314608,"url":"https://www.karger.com/Article/Pdf/366366"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="89539201"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/89539201/Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds"><img alt="Research paper thumbnail of Synthesis and Cytotoxicity of Novel 3-Aryl-1-(3′-dibenzylaminomethyl-4′-hydroxyphenyl)-propenones and Related Compounds" class="work-thumbnail" src="https://attachments.academia-assets.com/93326281/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/89539201/Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds">Synthesis and Cytotoxicity of Novel 3-Aryl-1-(3′-dibenzylaminomethyl-4′-hydroxyphenyl)-propenones and Related Compounds</a></div><div class="wp-workCard_item"><span>CHEMICAL &amp; PHARMACEUTICAL BULLETIN</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to the formation of a novel series of 4-hydroxy-3-dibenzylaminomethyl chalcones (7a-e) instead of 4-hydroxy-3,5bis-(dibenzylaminomethyl)chalcones 4. In order to rationalise the formation of monoadduct 7, energy minimized model structures of 4a and 7a were compared. The in vitro cytotoxic activities of 7a-e were tested against PC-3 cell lines for the first time in this study and compared with the precursor 4-hydroxychalcones (1a-e). Except for compound 7a (IC 50 : 19.85 m mM), insertion of dibenzylaminomethyl function into 4-hydroxychalcones resulted in complete loss of cytotoxic activity. The results suggested that it is not only the pK a but also the shape and size of the amine that is critical in governing the cytotoxic activity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="75424badaa3b833e31af9a2c27c178c5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":93326281,"asset_id":89539201,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/93326281/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="89539201"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="89539201"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 89539201; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=89539201]").text(description); $(".js-view-count[data-work-id=89539201]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 89539201; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='89539201']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 89539201, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "75424badaa3b833e31af9a2c27c178c5" } } $('.js-work-strip[data-work-id=89539201]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":89539201,"title":"Synthesis and Cytotoxicity of Novel 3-Aryl-1-(3′-dibenzylaminomethyl-4′-hydroxyphenyl)-propenones and Related Compounds","translated_title":"","metadata":{"publisher":"Pharmaceutical Society of Japan","grobid_abstract":"The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to the formation of a novel series of 4-hydroxy-3-dibenzylaminomethyl chalcones (7a-e) instead of 4-hydroxy-3,5bis-(dibenzylaminomethyl)chalcones 4. In order to rationalise the formation of monoadduct 7, energy minimized model structures of 4a and 7a were compared. The in vitro cytotoxic activities of 7a-e were tested against PC-3 cell lines for the first time in this study and compared with the precursor 4-hydroxychalcones (1a-e). Except for compound 7a (IC 50 : 19.85 m mM), insertion of dibenzylaminomethyl function into 4-hydroxychalcones resulted in complete loss of cytotoxic activity. The results suggested that it is not only the pK a but also the shape and size of the amine that is critical in governing the cytotoxic activity.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"CHEMICAL \u0026amp; PHARMACEUTICAL BULLETIN","grobid_abstract_attachment_id":93326281},"translated_abstract":null,"internal_url":"https://www.academia.edu/89539201/Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds","translated_internal_url":"","created_at":"2022-10-30T09:38:04.382-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32891153,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":93326281,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326281/thumbnails/1.jpg","file_name":"_pdf.pdf","download_url":"https://www.academia.edu/attachments/93326281/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Synthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326281/_pdf-libre.pdf?1667150945=\u0026response-content-disposition=attachment%3B+filename%3DSynthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf\u0026Expires=1734541249\u0026Signature=GXxogGONHgEsqySftD7ejmX8gugbYqdJujb6Hx08UzBpFSvQ4FwtPhO5G8w5QHpkkF~aDUDymcxlfflgYGooCFEjqmP8meChQu86nVxUMsj2Hl3kl209U~aa7LaJzaENahnQBbRkuQrtschsMh3cuLHJnUg81TE21aBgKgazDo76fHDNl4ogIgH5bBAPzYbRX1vuz1cJNSp7LdaMtmCsQG~6qpIgP1cbNhUe~eHxT-P6HSeDA-TYB0PPXXFK9G9VfWbfXBDVVFngM8mnhApV2wykreV4wvptNvSUwRTGToT~GOV5x1XWhH6-SnqjEsfHsir4kvSOGiGAyRAOMsYIkg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Synthesis_and_Cytotoxicity_of_Novel_3_Aryl_1_3_dibenzylaminomethyl_4_hydroxyphenyl_propenones_and_Related_Compounds","translated_slug":"","page_count":7,"language":"en","content_type":"Work","summary":"The reaction of various 4-hydroxychalcones (1a-e) with paraformaldehyde and dibenzylamine led to the formation of a novel series of 4-hydroxy-3-dibenzylaminomethyl chalcones (7a-e) instead of 4-hydroxy-3,5bis-(dibenzylaminomethyl)chalcones 4. In order to rationalise the formation of monoadduct 7, energy minimized model structures of 4a and 7a were compared. The in vitro cytotoxic activities of 7a-e were tested against PC-3 cell lines for the first time in this study and compared with the precursor 4-hydroxychalcones (1a-e). Except for compound 7a (IC 50 : 19.85 m mM), insertion of dibenzylaminomethyl function into 4-hydroxychalcones resulted in complete loss of cytotoxic activity. The results suggested that it is not only the pK a but also the shape and size of the amine that is critical in governing the cytotoxic activity.","owner":{"id":32891153,"first_name":"Mustafa","middle_initials":null,"last_name":"Gul","page_name":"MustafaGul","domain_name":"atauni","created_at":"2015-07-07T23:59:25.498-07:00","display_name":"Mustafa Gul","url":"https://atauni.academia.edu/MustafaGul"},"attachments":[{"id":93326281,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/93326281/thumbnails/1.jpg","file_name":"_pdf.pdf","download_url":"https://www.academia.edu/attachments/93326281/download_file?st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&st=MTczNDUzNzY0OSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Synthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/93326281/_pdf-libre.pdf?1667150945=\u0026response-content-disposition=attachment%3B+filename%3DSynthesis_and_Cytotoxicity_of_Novel_3_Ar.pdf\u0026Expires=1734541249\u0026Signature=GXxogGONHgEsqySftD7ejmX8gugbYqdJujb6Hx08UzBpFSvQ4FwtPhO5G8w5QHpkkF~aDUDymcxlfflgYGooCFEjqmP8meChQu86nVxUMsj2Hl3kl209U~aa7LaJzaENahnQBbRkuQrtschsMh3cuLHJnUg81TE21aBgKgazDo76fHDNl4ogIgH5bBAPzYbRX1vuz1cJNSp7LdaMtmCsQG~6qpIgP1cbNhUe~eHxT-P6HSeDA-TYB0PPXXFK9G9VfWbfXBDVVFngM8mnhApV2wykreV4wvptNvSUwRTGToT~GOV5x1XWhH6-SnqjEsfHsir4kvSOGiGAyRAOMsYIkg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":12597,"name":"Crystallization","url":"https://www.academia.edu/Documents/in/Crystallization"},{"id":14054,"name":"Chemical","url":"https://www.academia.edu/Documents/in/Chemical"},{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy"},{"id":22050,"name":"Cytotoxicity","url":"https://www.academia.edu/Documents/in/Cytotoxicity"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":114715,"name":"Stereochemistry","url":"https://www.academia.edu/Documents/in/Stereochemistry"},{"id":184989,"name":"Carcinogens","url":"https://www.academia.edu/Documents/in/Carcinogens"},{"id":309949,"name":"Propane","url":"https://www.academia.edu/Documents/in/Propane"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":1162913,"name":"Mutagens","url":"https://www.academia.edu/Documents/in/Mutagens"},{"id":1271583,"name":"Aryl","url":"https://www.academia.edu/Documents/in/Aryl"},{"id":2898895,"name":"binding sites","url":"https://www.academia.edu/Documents/in/binding_sites"},{"id":3024741,"name":"ketones","url":"https://www.academia.edu/Documents/in/ketones"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":25314606,"url":"https://www.jstage.jst.go.jp/article/cpb/56/12/56_12_1675/_pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "a049cff333bfd2a3c376f1eaa03eebd8c6fba54112688f7fa5e08bb3d2b96fca", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="e2EKd5OYsfg6ayDhQ8+HskSydOQ4rzcF384Z/IQhuMofsLgMSZCGX9h0/KP6vZCAa+aSoEThMXaAf7jHPs2fog==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://atauni.academia.edu/MustafaGul" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="UJ1TqQ1gLfmYuIplqsLUOkBBb9uPg7f6LoxJdjwAPug0TOHS12gaXnqnVicTsMMIbxWJn/PNsYlxPehNhuwZgA==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>