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(PDF) lnc RNAs, hypoxia and metastasis | Luis Peso - Academia.edu

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This review will discuss the means by which hypoxia powers the mechanisms behind cancer progression, with a majority of examples from lung cancer, the leading malignancy in terms of incidence and mortality rates (the frequent reference toward lung cancer is also for simplification purposes and follow up of the global mechanism in the context of a disease). The effects induced by low oxygen levels are orchestrated by hypoxia-inducible factors (HIFs) which regulate the expression of numerous genes involved in cancer progression. Hypoxia induces epithelial-to-mesenchymal transition (EMT) and metastasis through a complex machinery, by mediating various pathways such as TGF-β, PI3k/Akt, Wnt, and Jagged/Notch. Concomitantly, hypoxic environment has a vast implication in angiogenesis by stimulating vessel growth through the HIF-1α/VEGF axis. 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data-author-id="34705037" href="https://independent.academia.edu/IanStratford">Ian Stratford</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Proceedings of the National Academy of Sciences, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth&quot;,&quot;attachmentId&quot;:43094785,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/15549361/Hypoxia_inducible_factor_1_modulates_gene_expression_in_solid_tumors_and_influences_both_angiogenesis_and_tumor_growth&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span 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facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35170366" href="https://independent.academia.edu/SantoshSalunke2">Santosh Salunke</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Oncotarget, 2015</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer 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class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="8" data-entity-id="6681475" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/6681475/Role_of_ETS_Transcription_Factors_in_the_Hypoxia_Inducible_Factor2_Target_Gene_Selection">Role of ETS Transcription Factors in the Hypoxia-Inducible Factor2 Target Gene Selection</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="10882131" href="https://jhusom.academia.edu/SeanTackett">Sean Tackett</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Role of ETS Transcription Factors in the 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data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14299903/Enhanced_Overexpression_of_an_HIF_1_Hypoxia_Related_Protein_in_Cancer_Cells">Enhanced Overexpression of an HIF-1/Hypoxia-Related Protein in Cancer Cells</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33258194" href="https://medipol.academia.edu/HakanCangul">Hakan Cangul</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Environmental Health Perspectives, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Enhanced Overexpression of an HIF-1/Hypoxia-Related Protein in Cancer 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="29142584" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/29142584/A_RNA_antagonist_of_hypoxia_inducible_factor_1_EZN_2968_inhibits_tumor_cell_growth">A RNA antagonist of hypoxia-inducible factor-1 , EZN-2968, inhibits tumor cell growth</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35381583" href="https://independent.academia.edu/HenrikSchr%C3%B8der">Henrik Schrøder</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Molecular Cancer Therapeutics, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="12" data-entity-id="7360857" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/7360857/Loss_of_HIF_1%CE%B1_in_endothelial_cells_disrupts_a_hypoxia_driven_VEGF_autocrine_loop_necessary_for_tumorigenesis">Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="12976603" href="https://independent.academia.edu/tangnan">nan tang</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer Cell, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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href="https://kth.academia.edu/CeciliaWilliams">Cecilia Williams</a></div><p class="ds-related-work--metadata ds2-5-body-xs">PLOS ONE, 2015</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Estrogen Receptor β2 Induces Hypoxia Signature of Gene Expression by Stabilizing HIF-1α in Prostate Cancer&quot;,&quot;attachmentId&quot;:42960028,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/22321032/Estrogen_Receptor_%CE%B22_Induces_Hypoxia_Signature_of_Gene_Expression_by_Stabilizing_HIF_1%CE%B1_in_Prostate_Cancer&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="217549968" href="https://independent.academia.edu/HKalinski">Hagar Kalinski</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Oncogene, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Ero1-Lα plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer&quot;,&quot;attachmentId&quot;:93425756,&quot;attachmentType&quot;:&quot;pdf&quot;,&quot;work_url&quot;:&quot;https://www.academia.edu/89669162/Ero1_L%CE%B1_plays_a_key_role_in_a_HIF_1_mediated_pathway_to_improve_disulfide_bond_formation_and_VEGF_secretion_under_hypoxia_implication_for_cancer&quot;,&quot;alternativeTracking&quot;:true}"><span class="material-symbols-outlined" 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