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Jato</a>, <a href="https://publications.waset.org/abstracts/search?q=Ovye%20Akyengo"> Ovye Akyengo</a>, <a href="https://publications.waset.org/abstracts/search?q=John%20Akighir"> John Akighir</a> </p> <p class="card-text"><strong>Abstract:</strong></p> All humans will experience some type of wound in every lifetime. Most wounds heal quickly with little or no attention but, many people suffer from wounds that are complex and/or persistent therefore posing a burden. This study was designed to assess the efficacy of Mitrcarpus villous ointment against honey in diabetic rats. To achieve this, percentage wound closure and collagen assessments were used to express treatment efficacy. Results show that on day 21, rats treated with M. villosus ointment had the highest percentage closure (94.5%) while honey treated and non-treated recorded 90.0% and 83.3% respectively. Similarly, a significant difference (p < 0.05) was observed on day 21 in the total collagen deposited in wounds of diabetic rats (10.57 ± 0.7) and M. villous ointment treated wounds (11.77 ± 0.4) as compared with the non-treated diabetic rats. M. villosus ointment was efficacious in healing wounds in diabetic rats and heals wound faster than honey and may hold potential for wound healing in diabetes mellitus sufferers. However, the wound healing mechanism of this ointment <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=collagen" title="collagen">collagen</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20rats" title=" diabetic rats"> diabetic rats</a>, <a href="https://publications.waset.org/abstracts/search?q=honey" title=" honey"> honey</a>, <a href="https://publications.waset.org/abstracts/search?q=Mitracarpus%20villosus" title=" Mitracarpus villosus"> Mitracarpus villosus</a>, <a href="https://publications.waset.org/abstracts/search?q=ointment" title=" ointment"> ointment</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20healing" title=" wound healing"> wound healing</a> </p> <a href="https://publications.waset.org/abstracts/139065/comparative-wound-healing-potential-of-mitracarpus-villosus-ointment-and-honey-in-diabetic-albino-rats-by-collagen-assessment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/139065.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">205</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">809</span> Evaluation of Excision Wound Healing Activity of Ethanolic Extract of Michelia Champaca ın Diabetic Wistar Rats </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Smita%20Shenoy">Smita Shenoy</a>, <a href="https://publications.waset.org/abstracts/search?q=Amoolya%20Gowda"> Amoolya Gowda</a>, <a href="https://publications.waset.org/abstracts/search?q=Tara%20Shanbhag"> Tara Shanbhag</a>, <a href="https://publications.waset.org/abstracts/search?q=Krishnananda%20Prabhu"> Krishnananda Prabhu</a>, <a href="https://publications.waset.org/abstracts/search?q=Venumadhav%20Nelluri"> Venumadhav Nelluri </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The study was undertaken to assess the effect of ethanolic extract of Michelia champaca on excision wound healing in diabetic wistar rats. Excision wound was made in five groups of rats after inducing diabetes with streptozotocin in four groups. Paraffin was applied to wounds in nondiabetic and diabetic control and 2.5%, 5%, 10% ointment of extract to wounds in three diabetic test groups. Monitoring of wound contraction rate, the period of epithelization and histopathological examination of granulation tissue was done. There was a significant (p < 0.05) decrease in the period of epithelization and a significant increase in the wound contraction rate on day 12 and 16 in rats treated with 5% and 10% ointment as compared to diabetic rats. There was a better organization of collagen fibers in the granulation tissue of wounds treated with 10% ointment. The higher dose of ethanolic extract of Michelia champaca promoted wound healing in diabetic Wistar rats. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Michelia%20champaca" title="Michelia champaca">Michelia champaca</a>, <a href="https://publications.waset.org/abstracts/search?q=excision%20wound" title=" excision wound"> excision wound</a>, <a href="https://publications.waset.org/abstracts/search?q=contraction" title=" contraction"> contraction</a>, <a href="https://publications.waset.org/abstracts/search?q=epithelization" title=" epithelization"> epithelization</a> </p> <a href="https://publications.waset.org/abstracts/1352/evaluation-of-excision-wound-healing-activity-of-ethanolic-extract-of-michelia-champaca-in-diabetic-wistar-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1352.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">362</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">808</span> Efficacy of Umbilical Cord Lining Stem Cells For Wound Healing in Diabetic Murine Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fui%20Ping%20Lim">Fui Ping Lim</a>, <a href="https://publications.waset.org/abstracts/search?q=Wen%20Choong%20Chua"> Wen Choong Chua</a>, <a href="https://publications.waset.org/abstracts/search?q=Toan%20Thang%20Phan"> Toan Thang Phan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim: This study investigates the roles of Cord Lining Stem Cells (CLSCs) as potential therapeutic agents for diabetic wounds. Method: 20 genetically diabetic db/db mice were randomly assigned to two arms; (i) control group received placebo treatment (sham media or cells delivery material), and (ii) active comparator received CLSCs. Two full-thickness wounds, each sized 10mm X 10mm were created, one on each side of the midline on the back of the mice. Digital pictures were taken on day 1, 3, 7, 10, 14, 17, 21, 24, 28. Wound areas were analyzed with ImageJ TM software and calculated as percentage of the original wound. Time to closure was defined as the day the wound bed was completely epithelized and filled with new tissues. Results: The CLSCs-treated wounds, showed a significant increase in the percentage of wound closure and achieved 100% closure of the wound sooner than the control group by an average of 3.7 days. The mice treated with CLSCs have a shorter wound closure time (mean closure day: 19.8 days) as compared to the control group (mean closure day: 23.5 days). Conclusion: Our preliminary findings inferred that CLSCs treated wound achieved higher percentage of wound closure within a shorter duration of time. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cord%20lining%20stem%20cell" title="cord lining stem cell">cord lining stem cell</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20wound" title=" diabetic wound"> diabetic wound</a>, <a href="https://publications.waset.org/abstracts/search?q=stem%20cell" title=" stem cell"> stem cell</a>, <a href="https://publications.waset.org/abstracts/search?q=wound" title=" wound"> wound</a> </p> <a href="https://publications.waset.org/abstracts/53878/efficacy-of-umbilical-cord-lining-stem-cells-for-wound-healing-in-diabetic-murine-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/53878.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">291</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">807</span> Quantitative Evaluation of Diabetic Foot Wound Healing Using Hydrogel Nanosilver Based Dressing vs. Traditional Dressing: A Prospective Randomized Control Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ehsan%20A.%20Yahia">Ehsan A. Yahia</a>, <a href="https://publications.waset.org/abstracts/search?q=Ayman%20E.%20El-Sharkawey"> Ayman E. El-Sharkawey</a>, <a href="https://publications.waset.org/abstracts/search?q=Magda%20M.%20Bayoumi"> Magda M. Bayoumi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Wound dressings perform a crucial role in cutaneous wound management due to their ability to protect wounds and promote dermal and epidermal tissue regeneration. Aim: To evaluate the effectiveness of using hydrogel/nano silver-based dressing vs. traditional dressing on diabetic foot wound healing. Methods: Sixty patients with type-2 diabetes hospitalized for diabetic foot wound treatment were recruited from selected Surgical departments. A prospective randomized control study was carried. Results: The results showed that the percentage of a reduction rate of the ulcer by the third week of the treatment in the hydrogel/nano silver-based dressing group was higher (15.11%) than in the traditional wound dressing group (33.44%). Moreover, the mean ulcer size "sq mm" in the hydrogel/nano silver-based dressing group recognized a faster healing rate (15.11±7.89) and considerably lesser in comparison to the traditional in the third week (21.65±8.4). Conclusion: The hydrogel/nanosilver-based dressing showed better results than traditional dressing in managing diabetic ulcer foot. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetes" title="diabetes">diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20care" title=" wound care"> wound care</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20foot" title=" diabetic foot"> diabetic foot</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20dressing" title=" wound dressing"> wound dressing</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel%20nanosilver" title=" hydrogel nanosilver"> hydrogel nanosilver</a> </p> <a href="https://publications.waset.org/abstracts/152560/quantitative-evaluation-of-diabetic-foot-wound-healing-using-hydrogel-nanosilver-based-dressing-vs-traditional-dressing-a-prospective-randomized-control-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/152560.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">118</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">806</span> Investigation of Cold Atmospheric Plasma Exposure Protocol on Wound Healing in Diabetic Foot Ulcer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=P.%20Akbartehrani">P. Akbartehrani</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Khaledi%20Pour"> M. Khaledi Pour</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Amini"> M. Amini</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Khani"> M. Khani</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Mohajeri%20Tehrani"> M. Mohajeri Tehrani</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20Ghasemi"> E. Ghasemi</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Charipoor"> P. Charipoor</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20Shokri"> B. Shokri</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A common problem between diabetic patients is foot ulcers which are chronic and require specialized treatment. Previous studies illustrate that Cold atmospheric plasma (CAP) has beneficial effects on wound healing and infection. Nevertheless, the comparison of different cap exposure protocols in diabetic ulcer wound healing remained to be studied. This study aims to determine the effect of two different exposure protocols on wound healing in diabetic ulcers. A prospective, randomized clinical trial was conducted at two clinics. Diabetic patients with G1 and G2 wanger classification diabetic foot ulcers were divided into two groups of study. One group was treated by the first protocol, which was treating wounds by argon-generated cold atmospheric plasma jet once a week for five weeks in a row. The other group was treated by the second protocol, which was treating wounds every three days for five weeks in a row. The wounds were treated for 40 seconds/cubic centimeter, while the nozzle tip was moved nonlocalized 1 cm above the wounds. A patient with one or more wounds could participate in different groups as wounds were separately randomized, which allow a participant to be treated several times during the study. The study's significant findings were two different reductions rate in wound size, microbial load, and two different healing speeds. This study concludes that CAP therapy by the second protocol yields more effective healing speeds, reduction in wound sizes, and microbial loads of foot ulcers in diabetic patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=wound%20healing" title="wound healing">wound healing</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20ulcers" title=" diabetic ulcers"> diabetic ulcers</a>, <a href="https://publications.waset.org/abstracts/search?q=cold%20atmospheric%20plasma" title=" cold atmospheric plasma"> cold atmospheric plasma</a>, <a href="https://publications.waset.org/abstracts/search?q=cold%20argon%20jet" title=" cold argon jet"> cold argon jet</a> </p> <a href="https://publications.waset.org/abstracts/140972/investigation-of-cold-atmospheric-plasma-exposure-protocol-on-wound-healing-in-diabetic-foot-ulcer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/140972.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">224</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">805</span> Photobiomodulation Activates WNT/β-catenin Signaling for Wound Healing in an in Vitro Diabetic Wound Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dimakatso%20B.%20Gumede">Dimakatso B. Gumede</a>, <a href="https://publications.waset.org/abstracts/search?q=Nicolette%20N.%20Houreld"> Nicolette N. Houreld</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetic foot ulcers (DFUs) are a complication of diabetes mellitus (DM), a metabolic disease caused by insulin resistance or insufficiency, resulting in hyperglycaemia and low-grade chronic inflammation. Current therapies for treating DFUs include wound debridement, glycaemic control, and wound dressing. However, these therapies are moderately effective as there is a recurrence of these ulcers and an increased risk of lower limb amputations. Photobiomodulation (PBM), which is the application of non-invasive low-level light for wound healing at the spectrum of 660-1000 nm, has shown great promise in accelerating the healing of chronic wounds. However, its underlying mechanisms are not clearly defined. Studies have indicated that PBM induces wound healing via the activation of signaling pathways that are involved in tissue repair, such as the transforming growth factor-β (TGF-β). However, other signaling pathways, such as the WNT/β-catenin pathway, which is also critical for wound repair, have not been investigated. This study aimed to elucidate if PBM at 660 nm and a fluence of 5 J/cm² activates the WNT/β-catenin signaling pathway for wound healing in a diabetic cellular model. Human dermal fibroblasts (WS1) were continuously cultured high-glucose (26.5 mM D-glucose) environment to create a diabetic cellular model. A central scratch was created in the diabetic model to ‘wound’ the cells. The diabetic wounded (DW) cells were thereafter irradiated at 660 nm and a fluence of 5 J/cm². Cell migration, gene expression and protein assays were conducted at 24- and 48-h post-PBM. The results showed that PBM at 660 nm and a fluence of 5 J/cm² significantly increased cell migration in diabetic wounded cells at 24-h post-PBM. The expression of CTNNB1, ACTA2, COL1A1 and COL3A1 genes was also increased in DW cells post-PBM. Furthermore, there was increased cytoplasmic accumulation and nuclear localization of β-catenin at 24 h post-PBM. The findings in this study demonstrate that PBM activates the WNT/β-catenin signaling pathway by inducing the accumulation of β-catenin in diabetic wounded cells, leading to increased cell migration and expression of wound repair markers. These results thus indicate that PBM has the potential to improve wound healing in diabetic ulcers via activation of the WNT/β-catenin signaling pathway. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=wound%20healing" title="wound healing">wound healing</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20ulcers" title=" diabetic ulcers"> diabetic ulcers</a>, <a href="https://publications.waset.org/abstracts/search?q=photobiomodulation" title=" photobiomodulation"> photobiomodulation</a>, <a href="https://publications.waset.org/abstracts/search?q=WNT%2F%CE%B2-catenin" title=" WNT/β-catenin"> WNT/β-catenin</a>, <a href="https://publications.waset.org/abstracts/search?q=signalling%20pathway" title=" signalling pathway"> signalling pathway</a> </p> <a href="https://publications.waset.org/abstracts/188444/photobiomodulation-activates-wntv-catenin-signaling-for-wound-healing-in-an-in-vitro-diabetic-wound-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188444.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">47</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">804</span> Changes in the Body Weight and Wound Contraction Rate Following Treatment with Piper betel Extract in Diabetic Wounds</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nurul%20Z.%20Sani">Nurul Z. Sani</a>, <a href="https://publications.waset.org/abstracts/search?q=Amalina%20N.%20Ghazali"> Amalina N. Ghazali</a>, <a href="https://publications.waset.org/abstracts/search?q=Azree%20Elmy"> Azree Elmy</a>, <a href="https://publications.waset.org/abstracts/search?q=Lee%20C.%20Yuen"> Lee C. Yuen</a>, <a href="https://publications.waset.org/abstracts/search?q=Zar%20C.%20Thent"> Zar C. Thent </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Piper betel (P. betel) leaves is widely used in Asian countries for treating diabetes mellitus and its complication. In our previous study, we observed the positive effect of P.betel extract on diabetic wounds following 3 and 7 days of treatment. The aim of the present study was to determine the effect of P.betel leaves extract in the diabetic rats was observed in terms of body weight and wound contraction rates following 5 days of the treatment. Total 64 male Sprague-Dawley rats were used and the experimental rats received a single dose of 60mg/kg of Streptozotocin (STZ) injection, intraperitoneally. Four full thickness (6mm) cutaneous wounds were created on dorsum of each rat. The rats were divideid into (n=8): Non-treated Control (NC), Non-treated Diabetic (ND), diabetic treated with commercial cream (SN) and diabetic treated with 50mg/kg of P.betel extract (PB). The rats were sacrificed on day 0 and 5 post wounding. Significant increased in wound closure rate, body weight was observed in PB group compared to ND. Histological deterioration was restored in the P. betel extract treated wounds. It is concluded that topical application with P.betel extract for 5 days of post wounding offers positive scientific value in diabetic rats. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetes" title="diabetes">diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=piper%20betel" title=" piper betel"> piper betel</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20healing" title=" wound healing"> wound healing</a>, <a href="https://publications.waset.org/abstracts/search?q=body%20weight" title=" body weight"> body weight</a>, <a href="https://publications.waset.org/abstracts/search?q=morphology" title=" morphology"> morphology</a> </p> <a href="https://publications.waset.org/abstracts/28740/changes-in-the-body-weight-and-wound-contraction-rate-following-treatment-with-piper-betel-extract-in-diabetic-wounds" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28740.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">558</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">803</span> Development of selective human matrix metalloproteinases-9 (hMMP-9) inhibitors as potent diabetic wound healing agents</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Geetakshi%20Arora">Geetakshi Arora</a>, <a href="https://publications.waset.org/abstracts/search?q=Danish%20Malhotra"> Danish Malhotra</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetic wounds are serious health issues and often fail to heal, leading to limb amputation that makes the life of the patient miserable. Delayed wound healing has been characterized by an increase in matrix metalloproteinase-9 (MMP-9). Thus research throughout the world has been going on to develop selective MMP-9 inhibitors for aiding diabetic wound healing. Bioactive constituents from natural sources always served as potential leads in drug development with high rates of success. Considering the need for novel selective MMP-9 inhibitors and the importance of natural bioactive compounds in drug development, we have screened a library of bioactive constituents from plant sources that were effective in diabetic wound healing on human MMP-9 (hMMP-9) using molecular docking studies. Screened constituents are ranked according to their dock score, ∆G value (binding affinity), and Ligand efficiency evaluated from FleXX docking and Hyde scoring modules available with drug designing platform LeadIT. Rhamnocitrin showed the highest correlation between dock score, ∆G value (binding affinity), and Ligand efficiency was further explored for binding interactions with hMMP-9. The overall study suggest that Rhamnocitrin is sufficiently decorated with both hydrophilic and hydrophobic substitutions that perfectly block hMMP-9 and act as a potential lead in the design and development of selective hMMP-9 inhibitors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=MMP-9" title="MMP-9">MMP-9</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20wound" title=" diabetic wound"> diabetic wound</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20docking" title=" molecular docking"> molecular docking</a>, <a href="https://publications.waset.org/abstracts/search?q=phytoconstituents" title=" phytoconstituents"> phytoconstituents</a> </p> <a href="https://publications.waset.org/abstracts/155307/development-of-selective-human-matrix-metalloproteinases-9-hmmp-9-inhibitors-as-potent-diabetic-wound-healing-agents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/155307.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">130</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">802</span> Implementation of Tissue Engineering Technique to Nursing of Unhealed Diabetic Foot Lesion</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Basuki%20Supartono">Basuki Supartono</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Diabetic wound risks limb amputation, and the healing remains challenging. Chronic Hyperglycemia caused the insufficient inflammatory response and impaired ability of the cells to regenerate. Tissue Engineering Technique is mandatory. Methods: Tissue engineering (TE)-based therapy Utilizing mononuclear cells, plasma rich platelets, and collagen applied on the damaged tissue Results: TE technique resulting in acceptable outcomes. The wound healed completely in 2 months. No adverse effects. No allergic reaction. No morbidity and mortality Discussion: TE-based therapy utilizing mononuclear cells, plasma rich platelets, and collagen are safe and comfortable to fix damaged tissues. These components stop the chronic inflammatory process and increase cells' ability for regeneration and restoration of damaged tissues. Both of these allow the wound to regenerate and heal. Conclusion: TE-based therapy is safe and effectively treats unhealed diabetic lesion. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetic%20foot%20lesion" title="diabetic foot lesion">diabetic foot lesion</a>, <a href="https://publications.waset.org/abstracts/search?q=tissue%20engineering%20technique" title=" tissue engineering technique"> tissue engineering technique</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20healing" title=" wound healing"> wound healing</a>, <a href="https://publications.waset.org/abstracts/search?q=stemcells" title=" stemcells"> stemcells</a> </p> <a href="https://publications.waset.org/abstracts/160271/implementation-of-tissue-engineering-technique-to-nursing-of-unhealed-diabetic-foot-lesion" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/160271.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">85</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">801</span> Enhanced Wound Healing Efficacy of Cordycepin-Melittin Nanoconjugate in Excised Wounds of Diabetic Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20Flaih%20Alotaibi">Mohammed Flaih Alotaibi</a>, <a href="https://publications.waset.org/abstracts/search?q=Rasheed%20Ahemad%20Shaik"> Rasheed Ahemad Shaik</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20Z.%20Nasrullah"> Mohammed Z. Nasrullah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetic foot ulcers are the foremost global healthcare burden. Hyperglycemia in diabetics is incriminating in impeding wound healing and it can allow for more severe medical issues. The study was intended to establish a nanoconjugate of cordycepin-melittin (COR-MEL) and evaluate its healing effects in wounded diabetic rats. Diabetes induced by injecting streptozotocin intraperitoneally (50 mg/kg, body weight). Therefore, animals were classified into various groups; diabetic untreated, vehicle-treated, COR alone, MEL alone, and COR-MEL nanoconjugate treated, respectively. Animals with diabetes were exposed to excision and treated with Vehicle, COR, MEL, or COR-MEL nanoconjugate topically. After 14 days, the wounded skin was sliced and subjected to histological and biochemical assessments. The formulated nanoconjugate has a particle size of 253.5± 17.4 nm by a polydispersity index of 0.36 ± 0.05, and a zeta potential of 1.72 ± 0.3 mV. The study demonstrated an accelerated wound contraction in COR-MEL-treated diabetic rats, which was further validated by histological analysis. The nanoconjugate further exhibited antioxidant activities by inhibiting the accumulation of malondialdehyde and exhaustion of superoxide dismutase and glutathione peroxidase enzymatic activities. The nanoconjugate further demonstrated an enhanced anti-inflammatory activity by retarding the expression of proinflammatory cytokines (IL-6 and TNF-α). Additionally, the nanoconjugate exhibits a strong expression of growth factors (TGF-β1, VEGF-A, and PDGFR-β), indicating enrichment of proliferation. Likewise, nanoconjugate increased the concentration of hydroxyproline as well as the mRNA expression of collagen, type I, alpha 1. Thus, it is concluded that the nanoconjugate possesses a potent wound-healing activity in diabetic rats via antioxidant, anti-inflammatory, and pro-angiogenetic mechanisms. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetic%20wounds" title="diabetic wounds">diabetic wounds</a>, <a href="https://publications.waset.org/abstracts/search?q=cordycepin" title=" cordycepin"> cordycepin</a>, <a href="https://publications.waset.org/abstracts/search?q=melittin" title=" melittin"> melittin</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoconjugate" title=" nanoconjugate"> nanoconjugate</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20healing" title=" wound healing"> wound healing</a> </p> <a href="https://publications.waset.org/abstracts/162134/enhanced-wound-healing-efficacy-of-cordycepin-melittin-nanoconjugate-in-excised-wounds-of-diabetic-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/162134.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">84</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">800</span> Stress Hyperglycaemia and Glycaemic Control Post Cardiac Surgery: Relaxed Targets May Be Acceptable</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nicholas%20Bayfield">Nicholas Bayfield</a>, <a href="https://publications.waset.org/abstracts/search?q=Liam%20Bibo"> Liam Bibo</a>, <a href="https://publications.waset.org/abstracts/search?q=Charley%20Budgeon"> Charley Budgeon</a>, <a href="https://publications.waset.org/abstracts/search?q=Robert%20Larbalestier"> Robert Larbalestier</a>, <a href="https://publications.waset.org/abstracts/search?q=Tom%20Briffa"> Tom Briffa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Stress hyperglycaemia is common following cardiac surgery. Its optimal management is uncertain and may differ by diabetic status. This study assesses the in-hospital glycaemic management of cardiac surgery patients and associated postoperative outcomes. Methods: A retrospective cohort analysis of all patients undergoing cardiac surgery at Fiona Stanley Hospital from February 2015 to May 2019 was undertaken. Management and outcomes of hyperglycaemia following cardiac surgery were assessed. Follow-up was assessed to 1 year postoperatively. Multivariate regression modelling was utilised. Results: 1050 non-diabetic patients and 689 diabetic patients were included. In the non-diabetic cohort, patients with mild (peak blood sugar level [BSL] < 14.3), transient stress hyperglycaemia managed without insulin were not at an increased risk of wound-related morbidity (P=0.899) or mortality at 1 year (P=0.483). Insulin management was associated with wound-related readmission to hospital (P=0.004) and superficial sternal wound infection (P=0.047). Prolonged or severe stress hyperglycaemia was predictive of hospital re-admission (P=0.050) but not morbidity or mortality (P=0.546). Diabetes mellitus was an independent risk factor 1-year mortality (OR; 1.972 [1.041–3.736], P=0.037), graft harvest site wound infection (OR; 1.810 [1.134–2.889], P=0.013) and wound-related readmission (OR; 1.866 [1.076–3.236], P=0.026). In diabetics, postoperative peak BSL > 13.9mmol/L was predictive of graft harvest site infections (OR; 3.528 [1.724-7.217], P=0.001) and wound-related readmission OR; 3.462 [1.540-7.783], P=0.003) regardless of modality of management. A peak BSL of 10.0-13.9 did not increase the risk of morbidity/mortality compared to a peak BSL of < 10.0 (P=0.557). Diabetics with a peak BSL of 13.9 or less did not have significantly increased morbidity/mortality outcomes compared to non-diabetics (P=0.418). Conclusion: In non-diabetic patients, transient mild stress hyperglycaemia following cardiac surgery does not uniformly require treatment. In diabetic patients, postoperative hyperglycaemia with peak BSL exceeding 13.9mmol/L was associated with wound-related morbidity and hospital readmission following cardiac surgery. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cardiac%20surgery" title="cardiac surgery">cardiac surgery</a>, <a href="https://publications.waset.org/abstracts/search?q=pulmonary%20embolism" title=" pulmonary embolism"> pulmonary embolism</a>, <a href="https://publications.waset.org/abstracts/search?q=pulmonary%20embolectomy" title=" pulmonary embolectomy"> pulmonary embolectomy</a>, <a href="https://publications.waset.org/abstracts/search?q=cardiopulmonary%20bypass" title=" cardiopulmonary bypass"> cardiopulmonary bypass</a> </p> <a href="https://publications.waset.org/abstracts/141697/stress-hyperglycaemia-and-glycaemic-control-post-cardiac-surgery-relaxed-targets-may-be-acceptable" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/141697.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">166</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">799</span> Integrating Wound Location Data with Deep Learning for Improved Wound Classification</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mouli%20Banga">Mouli Banga</a>, <a href="https://publications.waset.org/abstracts/search?q=Chaya%20Ravindra"> Chaya Ravindra</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Wound classification is a crucial step in wound diagnosis. An effective classifier can aid wound specialists in identifying wound types with reduced financial and time investments, facilitating the determination of optimal treatment procedures. This study presents a deep neural network-based classifier that leverages wound images and their corresponding locations to categorize wounds into various classes, such as diabetic, pressure, surgical, and venous ulcers. By incorporating a developed body map, the process of tagging wound locations is significantly enhanced, providing healthcare specialists with a more efficient tool for wound analysis. We conducted a comparative analysis between two prominent convolutional neural network models, ResNet50 and MobileNetV2, utilizing a dataset of 730 images. Our findings reveal that the RestNet50 outperforms MovileNetV2, achieving an accuracy of approximately 90%, compared to MobileNetV2’s 83%. This disparity highlights the superior capability of ResNet50 in the context of this dataset. The results underscore the potential of integrating deep learning with spatial data to improve the precision and efficiency of wound diagnosis, ultimately contributing to better patient outcomes and reducing healthcare costs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=wound%20classification" title="wound classification">wound classification</a>, <a href="https://publications.waset.org/abstracts/search?q=MobileNetV2" title=" MobileNetV2"> MobileNetV2</a>, <a href="https://publications.waset.org/abstracts/search?q=ResNet50" title=" ResNet50"> ResNet50</a>, <a href="https://publications.waset.org/abstracts/search?q=multimodel" title=" multimodel"> multimodel</a> </p> <a href="https://publications.waset.org/abstracts/188971/integrating-wound-location-data-with-deep-learning-for-improved-wound-classification" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188971.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">40</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">798</span> Fluorescent Ph-Sensing Bandage for Point-of-Care Wound Diagnostics</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Cherifi%20Katia">Cherifi Katia</a>, <a href="https://publications.waset.org/abstracts/search?q=Al-Hawat%20Marie-Lynn"> Al-Hawat Marie-Lynn</a>, <a href="https://publications.waset.org/abstracts/search?q=Tricou%20Leo-Paul"> Tricou Leo-Paul</a>, <a href="https://publications.waset.org/abstracts/search?q=Lamontagne%20Stephanie"> Lamontagne Stephanie</a>, <a href="https://publications.waset.org/abstracts/search?q=Tran%20Minh"> Tran Minh</a>, <a href="https://publications.waset.org/abstracts/search?q=Ngu%20Amy%20Ching%20Yie"> Ngu Amy Ching Yie</a>, <a href="https://publications.waset.org/abstracts/search?q=Manrique%20Gabriela"> Manrique Gabriela</a>, <a href="https://publications.waset.org/abstracts/search?q=Guirguis%20Natalie"> Guirguis Natalie</a>, <a href="https://publications.waset.org/abstracts/search?q=Machuca%20Parra%20Arturo%20Israel"> Machuca Parra Arturo Israel</a>, <a href="https://publications.waset.org/abstracts/search?q=Matoori%20Simon"> Matoori Simon</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetic foot ulcers (DFUs) are a serious and prevalent complication of diabetes. Current diagnostic options are limited to macroscopic wound analysis such as wound size, depth, and infection. Molecular diagnostics promise to improve DFU diagnosis, staging, and assessment of treatment response. Here, we developed a rapid and easy-to-use fluorescent pH-sensing bandage for wound diagnostics. In a fluorescent dye screen, we identified pyranine as the lead compound due to its suitable pH-sensing properties in the clinically relevant pH range of 6 to 9. To minimize the release of this dye into the wound bed, we screened a library of ionic microparticles and found a strong adhesion of the anionic dye to a cationic polymeric microparticle. These dye-loaded microparticles showed a strong fluorescence response in the clinically relevant pH range of 6 to 9 and a dye release below 1% after one day in biological media. The dye-loaded microparticles were subsequently encapsulated in a calcium alginate hydrogel to minimize the interaction of the microparticles with the wound tissue. This pH-sensing diagnostic wound dressing was tested on full-thickness dorsal wounds of mice, and a linear fluorescence response (R2 = 0.9909) to clinically relevant pH values was observed. These findings encourage further development of this pH-sensing system for molecular diagnostics in DFUs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=wound%20ph" title="wound ph">wound ph</a>, <a href="https://publications.waset.org/abstracts/search?q=fluorescence" title=" fluorescence"> fluorescence</a>, <a href="https://publications.waset.org/abstracts/search?q=diagnostics" title=" diagnostics"> diagnostics</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20foot%20ulcer" title=" diabetic foot ulcer"> diabetic foot ulcer</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20healing" title=" wound healing"> wound healing</a>, <a href="https://publications.waset.org/abstracts/search?q=chronic%20wounds" title=" chronic wounds"> chronic wounds</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetes" title=" diabetes"> diabetes</a> </p> <a href="https://publications.waset.org/abstracts/177542/fluorescent-ph-sensing-bandage-for-point-of-care-wound-diagnostics" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/177542.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">94</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">797</span> Smartphone Based Wound Assessment System for Diabetes Patients</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vaibhav%20V.%20Dixit">Vaibhav V. Dixit</a>, <a href="https://publications.waset.org/abstracts/search?q=Shubham%20Ajay%20Karwa"> Shubham Ajay Karwa </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetic foot ulcers speak to a critical medical problem. Right now, clinicians and medical caretakers primarily construct their injury evaluation in light of visual examination of wound size and mending status, while the patients themselves rarely have a chance to play a dynamic part. Henceforth, love quantitative and practical examination technique that empowers the patients and their parental figures to take a more dynamic part in every day wound care possibly can quicken wound recuperating, spare travel cost and diminish human services costs. Considering the commonness of cell phones with a high-determination computerized camera, evaluating wounds by breaking down pictures of ceaseless foot ulcers is an alluring choice. In this paper, we propose a novel injury picture examination framework actualized using feature extraction and color segmentation. Here we are using the Normalized minimum distance classifier for classifying the output. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetic" title="diabetic">diabetic</a>, <a href="https://publications.waset.org/abstracts/search?q=Gabor%20wavelet" title=" Gabor wavelet"> Gabor wavelet</a>, <a href="https://publications.waset.org/abstracts/search?q=normalized%20minimum%20distance%20classifier" title=" normalized minimum distance classifier"> normalized minimum distance classifier</a>, <a href="https://publications.waset.org/abstracts/search?q=quantiable%20parameters" title=" quantiable parameters"> quantiable parameters</a> </p> <a href="https://publications.waset.org/abstracts/75468/smartphone-based-wound-assessment-system-for-diabetes-patients" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75468.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">274</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">796</span> Integrating Fetal Membranes and collagen Layers Seeded with Fibroblasts and Keratinocytes for Diabetic Wound Ulcers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Atefeh%20Shahbazi">Atefeh Shahbazi</a>, <a href="https://publications.waset.org/abstracts/search?q=Zahra%20Shahravi"> Zahra Shahravi</a>, <a href="https://publications.waset.org/abstracts/search?q=Melika%20Mirghafari"> Melika Mirghafari</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The application of fetal membranes in chronic wounds, particularly diabetic foot ulcers (DFUs), has shown remarkable efficacy in enhancing wound healing, with a notable impact on re-epithelialization. Fetal membranes exhibit potent anti-inflammatory and anti-scarring properties, primarily due to their ability to eliminate allogeneic amniotic cells while retaining a cytokine-rich matrix during preparation. When integrated with collagen, this combination creates a unique microenvironment within the wound, fostering the expansion of epithelial cells, fibroblasts, and keratinocytes ex vivo, while preserving their normal phenotype. These cells, in turn, stimulate the release of growth factors and healing signals essential for tissue regeneration. This study aims to assess the efficacy of fetal membranes combined with collagen in the management of DFUs by comparing standard care alone with standard care supplemented with fetal membrane allograft treatment. The study involved two groups of patients: Group A: Patients received the wound dressing with fetal membranes and collagen, followed up for 3 months (15 patients).Group B: Patients were treated with only sterile gauze, with no specialized dressing, and were followed up for 3 months (15 patients). The healing progress in both groups will be evaluated, and the outcomes will provide valuable insights into the potential for further improvements in wound care strategies. Preliminary findings emphasize the significant potential of fetal membranes to enhance healing in chronic diabetic wounds, demonstrating their ability to accelerate tissue regeneration, reduce inflammation, and promote faster, more effective wound closure. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biological%20scaffold" title="biological scaffold">biological scaffold</a>, <a href="https://publications.waset.org/abstracts/search?q=stem%20cells" title=" stem cells"> stem cells</a>, <a href="https://publications.waset.org/abstracts/search?q=skin%20damage" title=" skin damage"> skin damage</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20foot%20ulcers" title=" diabetic foot ulcers"> diabetic foot ulcers</a> </p> <a href="https://publications.waset.org/abstracts/196414/integrating-fetal-membranes-and-collagen-layers-seeded-with-fibroblasts-and-keratinocytes-for-diabetic-wound-ulcers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/196414.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">30</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">795</span> The Study of Platelet-Rich Plasma(PRP) on Wounds of OLEFT Rats Using Expression of MMP-2, MMP-9 mRNA</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ho%20Seong%20Shin">Ho Seong Shin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: A research in relation to wound healing also showed that platelet-rich plasma (PRP) was effective on normal tissue regeneration. Nonetheless, there is no evidence that when platelet-rich plasma was applied on diabetic wound, it normalize diabetic wound healing process. In this study, we have analyzed matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) expression to know the effect of PRP on diabetic wounds using Reverse transcription-polymerase chain reaction (RT-PCR) of MMP-2, MMP-9 mRNA. Materials and Methods: Platelet-rich plasma (PRP) was prepared from blood of 6 rats. The whole 120-mL was added immediately to an anticoagulant. Citrate phosphonate dextrose(CPD) buffer (0.15 mg CPDmL) in a ratio of 1 mL of CPD buffer to 5 mL of blood. The blood was then centrifuged at 220g for 20minutes. The supernatant was saved to produce fibrin glue. The participate containing PRP was used for second centrifugation at 480g for 20 minutes. The pellet from the second centrifugation was saved and diluted with supernatant until the platelet concentration became 900,000/μL. Twenty male, 4week-old OLETF rats were underwent operation; each rat had two wounds created on left and right sides. The each wound of left side was treated with PRP gel, the wound of right side was treated with physiologic saline gauze. Results: RT-PCR analysis; The levels of MMP-2 mRNA in PRP applied tissues were positively related to postwounding days, whereas MMP-2 mRNA expression in saline-applied tissues remained in 5day after treatment. MMP-9 mRNA was undetectable in saline-applied tissues for either tissue, except 3day after treatment. Following PRP-applied tissues, MMP-9 mRNA expression was detected, with maximal expression being seen at third day. The levels of MMP-9 mRNA in PRP applied tissues were reported high intensity of optical density related to saline applied tissues. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetes" title="diabetes">diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=MMP-2" title=" MMP-2"> MMP-2</a>, <a href="https://publications.waset.org/abstracts/search?q=MMP-9" title=" MMP-9"> MMP-9</a>, <a href="https://publications.waset.org/abstracts/search?q=OLETF" title=" OLETF"> OLETF</a>, <a href="https://publications.waset.org/abstracts/search?q=PRP" title=" PRP"> PRP</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20healing%0D%0AMMP-9" title=" wound healing MMP-9"> wound healing MMP-9</a> </p> <a href="https://publications.waset.org/abstracts/39065/the-study-of-platelet-rich-plasmaprp-on-wounds-of-oleft-rats-using-expression-of-mmp-2-mmp-9-mrna" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39065.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">277</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">794</span> Role of Hyperbaric Oxygen Therapy in Management of Diabetic Foot</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Magdy%20Al%20Shourbagi">Magdy Al Shourbagi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetes mellitus is the commonest cause of neuropathy. The common pattern is a distal symmetrical sensory polyneuropathy, associated with autonomic disturbances. Less often, Diabetes mellitus is responsible for a focal or multifocal neuropathy. Common causes for non-healing of diabetic foot are the infection and ischemia. Diabetes mellitus is associated with a defective cellular and humoral immunity. Particularly, decreased phagocytosis, decreased chemotaxis, impaired bacterial killing and abnormal lymphocytic function resulting in a reduced inflammatory reaction and defective wound healing. Hyperbaric oxygen therapy is defined by the Undersea and Hyperbaric Medical Society as a treatment in which a patient intermittently breathes 100% oxygen and the treatment chamber is pressurized to a pressure greater than sea level (1 atmosphere absolute). The pressure increase may be applied in mono-place (single person) or multi-place chambers. Multi-place chambers are pressurized with air, with oxygen given via face mask or endotracheal tube; while mono-place chambers are pressurized with oxygen. Oxygen gas plays an important role in the physiology of wound healing. Hyperbaric oxygen therapy can raise tissue oxygen tensions to levels where wound healing can be expected. HBOT increases the killing ability of leucocytes also it is lethal for certain anaerobic bacteria and inhibits toxin formation in many other anaerobes. Multiple anecdotal reports and studies in HBO therapy in diabetic patients report that HBO can be an effective adjunct therapy in the management of diabetic foot wounds and is associated with better functional outcomes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hyperbari%20oxygen%20therapy" title="hyperbari oxygen therapy">hyperbari oxygen therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20foot" title=" diabetic foot"> diabetic foot</a>, <a href="https://publications.waset.org/abstracts/search?q=neuropathy" title=" neuropathy"> neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=multiplace%20chambers" title=" multiplace chambers"> multiplace chambers</a> </p> <a href="https://publications.waset.org/abstracts/52781/role-of-hyperbaric-oxygen-therapy-in-management-of-diabetic-foot" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/52781.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">296</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">793</span> Parallel among Urinary Tract Infection in Diabetic and Non-Diabetic Patients: A Case Study </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Khaled%20Khleifat">Khaled Khleifat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study detects the bacterial species that responsible for UTI in both diabetic patients and non-diabetic patients, Jordan. 116 urine samples were investigated in order to determine UTI-causing bacteria. These samples distributed unequally between diabetic male (12) and diabetic female (25) and also non-diabetic male (13) and non-diabetic female (66). The results represent that E.coli is responsible for UTI in both diabetic and non-diabetic patients (15.5% and 29.3% respectively) with large proportion (44.8%). This study showed that not all bacterial species that isolated from the non-diabetic sample could be isolated from diabetic samples. E. coli (15.5%), P. aeruginosa (4.3%), K. pneumonia (1.7%), P. mirabilis (2.6%), S. marcescens (0.9%), S. aureus (1.7%), S. pyogenes (1.7%), E. faecalis (0.9%), S. epidermidis (1.7%) and S. saprophyticus (0.9%). But E. aerogenes, E. cloacae, C. freundii, A. baumannii and B. subtilis are five bacterial species that can’t isolate from all diabetic samples. This study shows that for the treatment of UTI in both diabetic and non-diabetic patients, Chloramphenicol (30 μg), Ciprofloxacin (5 μg) and Vancomycin (30 μg) are more favorable than other antibiotics. In the same time, Cephalothin (30μg) is not recommended. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=urinary%20tract%20infections" title="urinary tract infections">urinary tract infections</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetes%20mellitus" title=" diabetes mellitus"> diabetes mellitus</a>, <a href="https://publications.waset.org/abstracts/search?q=bacterial%20species" title=" bacterial species"> bacterial species</a>, <a href="https://publications.waset.org/abstracts/search?q=infections" title=" infections"> infections</a> </p> <a href="https://publications.waset.org/abstracts/66558/parallel-among-urinary-tract-infection-in-diabetic-and-non-diabetic-patients-a-case-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/66558.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">332</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">792</span> Spectrum and Prevalence of Candida Infection in Diabetic Foot Ulcers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Seyed%20Reza%20Aghili">Seyed Reza Aghili</a>, <a href="https://publications.waset.org/abstracts/search?q=Tahereh%20Shokohi"> Tahereh Shokohi</a>, <a href="https://publications.waset.org/abstracts/search?q=Lotfollah%20Davoodi"> Lotfollah Davoodi</a>, <a href="https://publications.waset.org/abstracts/search?q=Zahra%20Kashi"> Zahra Kashi</a>, <a href="https://publications.waset.org/abstracts/search?q=Azam%20Moslemi"> Azam Moslemi</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahdi%20Abastabar"> Mahdi Abastabar</a>, <a href="https://publications.waset.org/abstracts/search?q=Iman%20Haghani"> Iman Haghani</a>, <a href="https://publications.waset.org/abstracts/search?q=Sabah%20Mayahi"> Sabah Mayahi</a>, <a href="https://publications.waset.org/abstracts/search?q=Asoudeh%20A."> Asoudeh A.</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: In diabetic foot ulcers, if fungal agents such as Candida species penetrate into the cutaneous or depth of ulcer, can increase the degree of the wound and cause Candia infection and make it more difficult to heal. Material & Methods: A cross-sectional study was performed on 100 diabetic foot ulcer patients in 2020 in Sari, Iran. patient's data and wound grade were recorded in a questionnaire. Candida infection was diagnosed with direct microscopic examination and culture of samples. Colony-PCR molecular method was used for ITS region of DNA and then PCR-RFLP with Msp1 enzyme and using HWP1 specific gene to determine species of Candida agent. Results: Of 100 patients, the mean age 62.1 ± 10.8 years, 95% type 2 diabetes, 83%>10 years duration diabetes, 59% male, 66%> poor education level, 99% married, 52% rural, 95% neuropathic symptoms, 88% using antibiotics, 69%HbA1C >9%, and mean ulcer degree 2.6±1.05 were. Candida infection was seen in 13% of the deep tissue of the wound and 7% cutaneous around the wound. The predominant Candida isolated was C. parapsilosis (71.5%), C .albicans (14.3%). Fungal infections caused by mold fungi were not detected. There was a statistically significant relationship between yeast infection and gender, rural, HbA1C and ulcer degree. Conclusion: Mycological evaluations often are ignored. Candida parapsilosis is the most common infectious agent in these patients and may require specific treatment. Therefore, more attention of physicians to Candida infections particularly, early diagnosis and effective treatment can help faster recovery and prevent amputation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetic%20foot%20ulcer" title="diabetic foot ulcer">diabetic foot ulcer</a>, <a href="https://publications.waset.org/abstracts/search?q=candida%20infection" title=" candida infection"> candida infection</a>, <a href="https://publications.waset.org/abstracts/search?q=risk%20factors" title=" risk factors"> risk factors</a>, <a href="https://publications.waset.org/abstracts/search?q=c.%20parapsilosis" title=" c. parapsilosis"> c. parapsilosis</a> </p> <a href="https://publications.waset.org/abstracts/141401/spectrum-and-prevalence-of-candida-infection-in-diabetic-foot-ulcers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/141401.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">210</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">791</span> Evaluation of the Effectiveness of the Argon Plasma Jet on Healing Process of the Wagner Grade 2 Diabetic Foot Ulcer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Khaledi%20Pour">M. Khaledi Pour</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Akbartehrani"> P. Akbartehrani</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Amini"> M. Amini</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Khani"> M. Khani</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Mohajeri%20Tehrani"> M. Mohajeri Tehrani</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Radi"> R. Radi</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20Shokri"> B. Shokri</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetic Foot Ulcer (DFU) is one of the costly severe complications of diabetes. Neuropathy and Peripheral Arterial Disease (PAD) due to diabetes are significant causes of this complication. In 10 years the patients with DFUs are twice as likely to die as patients without DFUs. Cold Atmospheric Plasma (CAP) is a promising tool for medical purposes. CAP generate reactive species at room temperature and are effective in killing bacteria and fibroblast proliferation. These CAP-based tools produce NO, which has bactericidal and angiogenesis properties. It also showed promising effects in the DFUs surface reduction and the time to wound closure. In this paper, we evaluated the effect of the Argon Plasma Jet (APJ) on the healing process of the Wagner Grade 2 DFUs in a randomized clinical trial. The 20 kHz sinusoidal voltage frequency derives the APJ. Patients (n=20) were randomly double-blinded assigned into two groups. These groups receive the standard care (SC, n=10) and the standard care with APJ treatment (SC+APJ, n=10) for five sessions in four weeks. The results showed that the APJ treatment along standard care could reduce the wound surface by 20 percent more than the standard care. Also, It showed a more influential role in controlling wound infection. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=argon%20plasma%20jet" title="argon plasma jet">argon plasma jet</a>, <a href="https://publications.waset.org/abstracts/search?q=cold%20atmospheric%20plasma" title=" cold atmospheric plasma"> cold atmospheric plasma</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetes" title=" diabetes"> diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20foot%20ulcer" title=" diabetic foot ulcer"> diabetic foot ulcer</a> </p> <a href="https://publications.waset.org/abstracts/141056/evaluation-of-the-effectiveness-of-the-argon-plasma-jet-on-healing-process-of-the-wagner-grade-2-diabetic-foot-ulcer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/141056.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">206</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">790</span> Hydrocolloid Dressings for Wound Healing</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Berk%20Kili%C3%A7">Berk Kiliç</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the medical and surgical fields, wound care is a critical and expansive industry. Hydrocolloid wound dressings have been introduced and are widely used due to their effectiveness in promoting healing, managing wound fluids, and protecting against infection. Hydrocolloid wound dressings have been introduced as effective solutions, adherence to wound surfaces and infection prevention. it fabricated different hydrocolloid wound dressings with myrrh resin, garlic and sorrel inorder to enhance healing properties. The physical and mechanical properties were evaluated to confirm which one is most suitable as a hydrocolloid wound dressing. it observations show that mirderm solution showed superior wound healing and fluid control properties compared to other prepared solutions. This indicates that “mirderm” could be a viable alternative to standard gauze and some commercial hydrocolloid dressings that do not contain myrrh. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=wound" title="wound">wound</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrocolloid" title=" hydrocolloid"> hydrocolloid</a>, <a href="https://publications.waset.org/abstracts/search?q=myrrh" title=" myrrh"> myrrh</a>, <a href="https://publications.waset.org/abstracts/search?q=garlic" title=" garlic"> garlic</a>, <a href="https://publications.waset.org/abstracts/search?q=sorrel" title=" sorrel"> sorrel</a> </p> <a href="https://publications.waset.org/abstracts/189282/hydrocolloid-dressings-for-wound-healing" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/189282.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">35</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">789</span> Frequency of Surgical Complications in Diabetic Patients after Kidney Transplantation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hakan%20Duger">Hakan Duger</a>, <a href="https://publications.waset.org/abstracts/search?q=Alparslan%20Ersoy"> Alparslan Ersoy</a>, <a href="https://publications.waset.org/abstracts/search?q=Canan%20Ersoy"> Canan Ersoy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The improvement of surgical techniques in recent years has reduced the frequency of postoperative complications in kidney transplant recipients. Novel immunosuppressive agents have reduced rates of graft loss due to acute rejection to less than 1%. However, surgical complications may still lead graft loss and morbidity in recipients. Because of potent immunosuppression, impaired wound healing and complications are frequent after transplantation. We compared the frequency of post-operative surgical complications in diabetic and non-diabetic patients after kidney transplantation. Materials and Methods: This retrospective study conducted in consecutive patients (213 females, 285 males, median age 39 years) who underwent kidney transplant surgery at our center between December 2005 and October 2015. The patients were divided into two groups: diabetics (46 ± 10 year, 26 males, 16 females) and non-diabetics (39 ± 12 year, 259 males, 197 females). Characteristics of both groups were obtained from medical records. Results: We performed 225 living and 273 deceased donor transplantations. Renal replacement type was hemodialysis in 60.8%, peritoneal dialysis in 17.3% and preemptive in 12%. The mean body mass indexes of the recipients were 24 ± 4.6 kg/m², donor age was 48.6 ± 14.3 years, cold ischemic time was 11.3 ± 6.1 hours, surgery time was 4.9 ± 1.2 hours, and recovery time was 54±31 min. The mean hospitalization duration was 19.1 ± 13.5 days. The frequency of postoperative surgical complications was 43.8%. There was no significant difference between the ratios of post-operative surgical complications in non-diabetic (43.5%) and diabetic (47.4%) groups (p=0.648). Post-operative surgical complications were lymphocele (24.6% vs. 23.7%), delayed wound healing (13.2% vs. 7.6%), hematoma (7.8% vs.15.8 %), urinary leak (4.6% vs. 5.3%), hemorrhage (5.1% vs. 0%), hydronephrosis (2.2% vs. 0%), renal artery thrombosis (1.5% vs. 0%), renal vein thrombosis (1% vs. 2.6%), urinoma (0.7% vs. 0%), urinary obstruction (0.5% vs. 0%), ureteral stenosis (0.5% vs. 0%) and ureteral reflux (0.2% vs. 0%) in non-diabetic and diabetic groups, respectively (p > 0.05). Mean serum creatinine levels in non-diabetics and diabetics were 1.43 ± 0.81 and 1.61 ± 0.96 mg/dL at 1st month (p=0.198). At the 6th month, the mean graft and patient survival times in patients with post-operative surgical complications were significantly lower than in those who did not (162.9 ± 3.4 vs. 175.6 ± 1.5 days, p=0.008, and 171 ± 2.9 vs. 176.1 ± 1.6 days, p=0.047, respectively). However, patient survival durations of non-diabetic (173 ± 27) and diabetic (177 ± 13 day) groups were comparable (p=0.396). Conclusion: As a result, we concluded that surgical complications such as lymphocele and delayed wound healing were common and that frequency of these complications in diabetic recipients did not differ from non-diabetic one. All persons involved in the postoperative care of kidney transplant recipients be aware of the potential surgical complications for rapid diagnosis and treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=kidney%20transplantation" title="kidney transplantation">kidney transplantation</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetes%20mellitus" title=" diabetes mellitus"> diabetes mellitus</a>, <a href="https://publications.waset.org/abstracts/search?q=surgery" title=" surgery"> surgery</a>, <a href="https://publications.waset.org/abstracts/search?q=complication" title=" complication"> complication</a> </p> <a href="https://publications.waset.org/abstracts/82748/frequency-of-surgical-complications-in-diabetic-patients-after-kidney-transplantation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/82748.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">181</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">788</span> Comparison of Visual Acuity Outcome and Complication after Phacoemulsification between Diabetic and Non-Diabetic Patients at Burapha University Hospital, Chonburi, Thailand</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Luksanaporn%20Krungkraipetch">Luksanaporn Krungkraipetch</a> </p> <p class="card-text"><strong>Abstract:</strong></p> One hundred cataract patients with phacoemulsification were enrolled in the study to compare of visual acuity outcome and complication after phacoemulsification between diabetic and non-diabetic patients at Burapha University Hospital, Chonburi, Thailand. Fifty patients were diabetic (type II) group and 50 patients were non-diabetic group. All cases were operated by one doctor with the same pre-operative care, operation (phacoemulsification), and post-operative care. Visual acuity and complication after surgery were assessed after the operation for two years. There were no significant differences in demographic data between the two groups. The visual outcome values ≥ 2 lines and ≥ 20/40 had no significant differences between two groups after two years of surgery. The complication rate in diabetic group had cystoid macular edema 16%, rupture posterior capsule 8%, posterior capsule opacity 2%, uveitis 2 %, and 2% endophthalmitis. The non-diabetic group had cystoid macular edema 12%, rupture posterior capsule 8%, uveitis 2%, posterior capsule opacity 2%, and 2% wound leak. Comparison of visual acuity outcome and complication after phacoemulsification between diabetic and non-diabetic patients had no statistical significant differences between these two groups. It was found that cystoid macular edema was the most common complication in both groups and 10% of retinopathy progression was seen. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cataract" title="cataract">cataract</a>, <a href="https://publications.waset.org/abstracts/search?q=visual%20acuity" title=" visual acuity"> visual acuity</a>, <a href="https://publications.waset.org/abstracts/search?q=cataract%20extraction" title=" cataract extraction"> cataract extraction</a>, <a href="https://publications.waset.org/abstracts/search?q=phacoemulsification" title=" phacoemulsification"> phacoemulsification</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20retinopathy" title=" diabetic retinopathy"> diabetic retinopathy</a> </p> <a href="https://publications.waset.org/abstracts/34910/comparison-of-visual-acuity-outcome-and-complication-after-phacoemulsification-between-diabetic-and-non-diabetic-patients-at-burapha-university-hospital-chonburi-thailand" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/34910.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">353</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">787</span> Effects of Auxetic Antibacterial Zwitterion Carboxylate and Sulfate Copolymer Hydrogels for Diabetic Wound Healing Application</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Udayakumar%20Vee">Udayakumar Vee</a>, <a href="https://publications.waset.org/abstracts/search?q=Franck%20Quero"> Franck Quero</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Zwitterionic polymers generally have been viewed as a new class of antimicrobial and non-fouling materials. They offer a broad versatility for chemical modification and hence great freedom for accurate molecular design, which bear an equimolar number of homogenously distributed anionic and cationic groups along their polymer chains. This study explores the effectiveness of the auxetic zwitterion carboxylate/sulfonate hydrogel in the diabetic-induced mouse model. A series of silver metal-doped auxetic zwitterion carboxylate/sulfonate/vinylaniline copolymer hydrogels is designed via a 3D printer. Zwitterion monomers have been characterized by FT-IR and NMR techniques. The effect of changing the monomers and different loading ratios of Ag over zwitterion on the final hydrogel materials' antimicrobial properties and biocompatibility will be investigated in detail. The synthesized auxetic hydrogel has been characterized using a wide range of techniques to help establish the relationship between molecular level and macroscopic properties of these materials, including mechanical and antibacterial and biocompatibility and wound healing ability. This work's comparative studies and results provide new insights and guide us in choosing a better auxetic structured material for a broad spectrum of wound healing applications in the animal model. We expect this approach to provide a versatile and robust platform for biomaterial design that could lead to promising treatments for wound healing applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=auxetic" title="auxetic">auxetic</a>, <a href="https://publications.waset.org/abstracts/search?q=zwitterion" title=" zwitterion"> zwitterion</a>, <a href="https://publications.waset.org/abstracts/search?q=carboxylate" title=" carboxylate"> carboxylate</a>, <a href="https://publications.waset.org/abstracts/search?q=sulfonate" title=" sulfonate"> sulfonate</a>, <a href="https://publications.waset.org/abstracts/search?q=polymer" title=" polymer"> polymer</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20healing" title=" wound healing"> wound healing</a> </p> <a href="https://publications.waset.org/abstracts/143952/effects-of-auxetic-antibacterial-zwitterion-carboxylate-and-sulfate-copolymer-hydrogels-for-diabetic-wound-healing-application" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/143952.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">147</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">786</span> Antibacterial Zwitterion Carboxylate and Sulfonate Copolymer Auxetic Hydrogels for Diabetic Wound Healing Application</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Udayakumar%20Veerabagu">Udayakumar Veerabagu</a>, <a href="https://publications.waset.org/abstracts/search?q=Franck%20Quero"> Franck Quero</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Zwitterion carboxylate and sulfonate polymers generally have been viewed as a new class of antimicrobial and non-fouling materials. They offer a broad versatility for chemical modification and hence great freedom for accurate molecular design, which bear an equimolar number of homogenously distributed anionic and cationic groups along their polymer chains. This study explores the effectiveness of the auxetic zwitterion carboxylate/sulfonate hydrogel in the diabetic-induced mouse model. A series of silver metal-doped auxetic zwitterion carboxylate/sulfonate/vinylaniline copolymer hydrogels is designed via a 3D printer. Zwitterion monomers have been characterized by FT-IR and NMR techniques. The effect of changing the monomers and different loading ratios of Ag over zwitterion on the final hydrogel materials' antimicrobial properties and biocompatibility will be investigated in detail. The synthesized auxetic hydrogel has been characterized using a wide range of techniques to help establish the relationship between molecular level and macroscopic properties of these materials, including mechanical and antibacterial and biocompatibility and wound healing ability. This work's comparative studies and results provide new insights and guide us in choosing a better auxetic structured material for a broad spectrum of wound healing applications in the animal model. We expect this approach to provide a versatile and robust platform for biomaterial design that could lead to promising treatments for wound healing applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=auxetic" title="auxetic">auxetic</a>, <a href="https://publications.waset.org/abstracts/search?q=zwitterion" title=" zwitterion"> zwitterion</a>, <a href="https://publications.waset.org/abstracts/search?q=carboxylate" title=" carboxylate"> carboxylate</a>, <a href="https://publications.waset.org/abstracts/search?q=sulfonate" title=" sulfonate"> sulfonate</a>, <a href="https://publications.waset.org/abstracts/search?q=polymer" title=" polymer"> polymer</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20healing" title=" wound healing"> wound healing</a> </p> <a href="https://publications.waset.org/abstracts/144230/antibacterial-zwitterion-carboxylate-and-sulfonate-copolymer-auxetic-hydrogels-for-diabetic-wound-healing-application" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/144230.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">162</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">785</span> A Multidisciplinary Team Approach for Limb Salvage in a Rare Case of Pyoderma Gangrenosum in a Significant Circumferential Lower Extremity Wound Complicated by Diabetes and End-stage Renal Disease</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jenee%20Gooden">Jenee Gooden</a>, <a href="https://publications.waset.org/abstracts/search?q=Kevin%20Vasquez-monterroso"> Kevin Vasquez-monterroso</a>, <a href="https://publications.waset.org/abstracts/search?q=Lady%20Paula%20Dejesus"> Lady Paula Dejesus</a>, <a href="https://publications.waset.org/abstracts/search?q=Sandra%20Wainwright"> Sandra Wainwright</a>, <a href="https://publications.waset.org/abstracts/search?q=Daniel%20Kim"> Daniel Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Mackenzie%20Walker"> Mackenzie Walker</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Pyoderma gangrenosum (PG) is a rare, rapidly progressive, neutrophilic ulcerative colitis condition with an incidence of 3 to 10 cases per year ¹ ². Due to the similar appearance, PG is often misdiagnosed as a diabetic ulcer in diabetic patients. Though they may clinically appear similar in appearance, the treatment protocol and diagnostic criteria differ. Also, end-stage renal disease (ESRD) is often a condition seen in diabetic patients, which can have a significant impact on wound healing due to the wide range of uremic toxins³. This case study demonstrates a multidisciplinary team and multimodal treatment approach by podiatric surgery, general surgery, rheumatology, infectious disease, interventional cardiology, wound care and hyperbaric medicine for an uncontrolled diabetic with pyoderma gangrenosum of a significant circumferential wound, covering almost the entire right lower extremity. Methods:56 y.o male presents with multiple PG ulcerations, including the chest, right posterior lower extremity and sacrum. All ulcerations were previously managed by the same wound care specialist. His chief complaint was worsening PG ulcerations accompanied by a fever of 103 °F . This case study focuses on the wound to his RLE. Past medical history significant for diabetes mellitus type 2 with hemoglobin A1c of 10% and end stage renal disease (ESRD) on hemodialysis. A multidisciplinary team approach by podiatric surgery, general surgery, rheumatology, infectious disease, interventional cardiology, wound care and hyperbaric medicine was successfully used to perform right lower extremity limb salvage. The patient was managed by rheumatology for the continuation of prior medication, as well as the mutual agreement with wound care for the addition of dapsone. A coronary CT angiogram was performed by interventional cardiology, but no significant disease was noted, and no further vascular workup was necessary. Multiple surgical sharp wide excisional debridements with application of allografts and split thickness skin grafts for the circumferential ulceration that encompassed almost the entire right lower extremity were performed by both podiatric surgery and general surgery. Wound cultures and soft tissue biopsies were performed, and infectious disease managed antibiotic therapy. Hyperbaric oxygen therapy and wound vac therapy by wound care were also completed as adjunct management. Results: Prevention of leg amputation by limb salvage of the RLE was accomplished by a multidisciplinary team approach, with the wound size decreasing over a total of 29 weeks from 600 cm² to 12.0 x 3.5 x 0.2 cm. Our multidisciplinary team included podiatric surgery, general surgery, rheumatology, infectious disease, interventional cardiology, wound care and hyperbaric medicine. Discussion: Wound healing, in general, can have its challenges, and those challenges are only magnified when accompanied by multiple systemic illnesses. Though the negative impact of diabetes on wound healing is well known, the compound impact of being a diabetic with ESRD and having pyoderma gangrenosum is not. This case demonstrates the necessity for a multidisciplinary team approach with a wide array of treatment modalities to optimize wound healing and perform limb salvage with prevention of lower extremity amputation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetes" title="diabetes">diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=podiatry" title=" podiatry"> podiatry</a>, <a href="https://publications.waset.org/abstracts/search?q=pyoderma%20gangrenosum" title=" pyoderma gangrenosum"> pyoderma gangrenosum</a>, <a href="https://publications.waset.org/abstracts/search?q=end%20stage%20renal%20disease" title=" end stage renal disease"> end stage renal disease</a> </p> <a href="https://publications.waset.org/abstracts/170745/a-multidisciplinary-team-approach-for-limb-salvage-in-a-rare-case-of-pyoderma-gangrenosum-in-a-significant-circumferential-lower-extremity-wound-complicated-by-diabetes-and-end-stage-renal-disease" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170745.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">78</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">784</span> Seal and Heal Miracle Ointment: Effects of Cryopreserved and Lyophilized Amniotic Membrane on Experimentally Induced Diabetic Balb/C Mice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Elizalde%20D.%20Bana">Elizalde D. Bana</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Healing restores continuity and form through cell replication; hence, conserving structural integrity. In response to the worldwide pressing problem of chronic wounds in the healthcare delivery system, the researcher aims to provide effective intervention to preserve the structural integrity of the person. The wound healing effects of cryopreserved and lyophilized amniotic membrane (AM) of a term fetus embedded into two (2) concentrations (1.5 % and 1.0 %) of absorption-based ointment has been evaluated in vivo using the excision wound healing model 1x1 cm size. The total protein concentration in full term fetus was determined by the Biuret and Bradford methods, which are based on UV-visible spectroscopy. The percentages of protein presence in 9.5 mg (Mass total sample) of Amniotic membrane ranges between 14.77 – 14.46 % in Bradford method, while slightly lower to 13.78 – 13.80 % concentration in Biuret method, respectively. Bradford method evidently showed higher sensitivity for proteins than Biuret test. Overall, the amniotic membrane is composed principally of proteins in which a copious amount of literature substantially proved its healing abilities. After which, an area of 1 cm by 1 cm skin tissue was excised to its full thickness from the dorsolateral aspect of the isogenic mice and was applied twice a day with the ointment formulation having two (2) concentrations for the diabetic group and non-diabetic group. The wounds of each animal were left undressed and its area was measured every other day by a standard measurement formula from day 2,4,6,8,10,12 and 14. By the 14th day, the ointment containing 1.5 % of AM in absorption-based ointment applied to non-diabetic and diabetic group showed 100 % healing. The wound areas in the animals treated with the standard antibiotic, Mupirocin Ointment (Brand X) showed a 100% healing by the 14th day but with traces of scars, indicating that AM prepared from cryopreservation and lyophilization, at that given concentration, had a better wound healing property than the standard antibiotic. Four (4) multivariate tests were used which showed a significant interaction between days and treatments, meaning that the ointments prepared in two differing concentrations and induced in different groups of the mice had a significant effect on the percent of contraction over time. Furthermore, the evaluations of its effectiveness to wound healing were all significant although in differing degrees. It is observed that the higher the concentrations of amniotic membrane, the more effective are the results. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=wounds" title="wounds">wounds</a>, <a href="https://publications.waset.org/abstracts/search?q=healing" title=" healing"> healing</a>, <a href="https://publications.waset.org/abstracts/search?q=amniotic%20membrane%20ointments" title=" amniotic membrane ointments"> amniotic membrane ointments</a>, <a href="https://publications.waset.org/abstracts/search?q=biomedical" title=" biomedical"> biomedical</a>, <a href="https://publications.waset.org/abstracts/search?q=stem%20cell" title=" stem cell"> stem cell</a> </p> <a href="https://publications.waset.org/abstracts/32140/seal-and-heal-miracle-ointment-effects-of-cryopreserved-and-lyophilized-amniotic-membrane-on-experimentally-induced-diabetic-balbc-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/32140.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">304</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">783</span> CICAP: Promising Wound Healing Gel from Bee Products and Medicinal Plants</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=La%C3%AFd%20Boukra%C3%A2">Laïd Boukraâ</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Complementary and Alternative Medicine is an inclusive term that describes treatments, therapies, and modalities that are not accepted as components of mainstream education or practice, but that are performed on patients by some practitioners. While these treatments and therapies often form part of post-graduate education, study and writing, they are generally viewed as alternatives or complementary to more universally accepted treatments. Ancient civilizations used bee products and medicinal plants, but modern civilization and ‘education’ have seriously lessened our natural instinctive ability and capability. Despite the fact that the modern Western establishment appears to like to relegate apitherapy and aromatherapy to the status of 'folklore' or 'old wives' tales', they contain a vast spread of pharmacologically-active ingredients and each one has its own unique combination and properties. They are classified in modern herbal medicine according to their spheres of action. Bee products and medicinal plants are well-known natural product for their healing properties and their increasing popularity recently as they are widely used in wound healing. Honey not only has antibacterial properties which can help as an antibacterial agent but also has chemical properties which may further help in the wound healing process. A formulation with honey as its main component was produced into a honey gel. This new formulation has enhanced texture and is more user friendly for usage as well. This new formulation would be better than other formulas as it is hundred percent consisting of natural products and has been made into a better formulation. In vitro assay, animal model study and clinical trials have shown the effectiveness of LEADERMAX for the treatment of diabetic foot, burns, leg ulcer and bed sores. This one hundred percent natural product could be the best alternative to conventional products for wound and burn management. The advantages of the formulation are: 100% natural, affordable, easy to use, strong power of absorption, dry surface on the wound making a film, will not stick to the wound bed; helps relieve wound pain, inflammation, edema and bruising while improving comfort. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bed%20sore%20bee%20products" title="bed sore bee products">bed sore bee products</a>, <a href="https://publications.waset.org/abstracts/search?q=burns" title=" burns"> burns</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20foot" title=" diabetic foot"> diabetic foot</a>, <a href="https://publications.waset.org/abstracts/search?q=medicinal%20plants" title=" medicinal plants"> medicinal plants</a>, <a href="https://publications.waset.org/abstracts/search?q=leg%20ulcer" title=" leg ulcer"> leg ulcer</a>, <a href="https://publications.waset.org/abstracts/search?q=wounds" title=" wounds"> wounds</a> </p> <a href="https://publications.waset.org/abstracts/41515/cicap-promising-wound-healing-gel-from-bee-products-and-medicinal-plants" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/41515.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">340</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">782</span> Risk Factors for Diabetic Foot: Upper Egypt Experience</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ali%20Kassem">Ali Kassem</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Alsenbasy"> Mohamed Alsenbasy</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20Nagaah"> Ahmed Nagaah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Diabetic foot is one of the often neglected complications of diabetes mellitus It was reported that patients of diabetic foot ulcer (DFU) have considerable morbidity and mortality. Due to arterial abnormalities, diabetic neuropathy, as well as the tendency to delayed wound healing, foot infection and or gangrene is relatively common in diabetic patients. Foot related problems are responsible for up to 50% of diabetic related hospital admissions. Aim of work: The aim of the present study is to assess the risk factors for DFU in diabetic patients attending Sohag University Hospitals (Upper Egypt) Material and methods: The present study includes 100 diabetic foot patients attending the diabetic outpatient clinic of Sohag University Hospitals. For all of the studied patients the following were done: Full medical history and clinical examination; thorough foot examination; Laboratory tests including: Blood glucose level, HBA1c, serum lipids and renal function tests, ECG and Echocardiography, Doppler study on the lower limbs. Results: Sixty eight percent of the affected patients were males versus 32 % female patients. All male patients and none of the female were smoker. Seventy nine percent of patients were living in rural areas versus 14 % in urban areas. Duration of diabetes was more than 12 years in 74%, less than 12 years in 26% of patients. Fifty percent of patients have associated hypertension, 46% have dyslipidemia, 18% have ischemic heart disease or old myocardial infarction and 8% have impaired renal function. History of previous foot ulcers was reported in 11 % and foot amputation in 2% of patients. Conclusion: Male gender, low socioeconomic status, smoking, long duration of diabetes, other cardiovascular risk factors particularly hypertension and previous history of foot ulceration are the major risk factors for diabetic foot in our locality. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetic%20foot" title="diabetic foot">diabetic foot</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20neuropathy" title=" diabetic neuropathy"> diabetic neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=foot%20gangrene" title=" foot gangrene"> foot gangrene</a>, <a href="https://publications.waset.org/abstracts/search?q=risk%20factors%20for%20diabetic%20complications" title=" risk factors for diabetic complications"> risk factors for diabetic complications</a> </p> <a href="https://publications.waset.org/abstracts/36460/risk-factors-for-diabetic-foot-upper-egypt-experience" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/36460.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">384</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">781</span> Dose Determination of Tenebrio molitor (Mealworm) Extract as an Anti-Diabetic Agent</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Al%20Rizqi%20Dharma%20Fauzi">Muhammad Al Rizqi Dharma Fauzi</a>, <a href="https://publications.waset.org/abstracts/search?q=Dwi%20Yulian%20Fahruddin%20Shah"> Dwi Yulian Fahruddin Shah</a>, <a href="https://publications.waset.org/abstracts/search?q=Andre%20Pratama"> Andre Pratama</a>, <a href="https://publications.waset.org/abstracts/search?q=Ari%20Hasna%20Widyapuspa"> Ari Hasna Widyapuspa</a>, <a href="https://publications.waset.org/abstracts/search?q=Ganden%20Supriyanto"> Ganden Supriyanto</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetes mellitus is still known as one of diseases which give a big amount of death in the world. From 2012 to 2014, diabetes is estimated to have resulted in 1.5 to 4.9 million deaths each year. In this paper, we present our research in the analysis and dose determination of Tenebrio molitor (Mealworm) extract as an anti-diabetic agent which is believed by Indonesian people as a traditional treatment to prevent and treat diabetes. We found that Tenebrio molitor extract has a potential as an anti-diabetic agent by in vitro test to Mus musculus which were divided into six group of treatment. Our dose determination analysis gave a conclusion that at 2,5 g/mL of concentration of the extract would give the optimal result in healing a wound given to Mus musculus which were induced by aloxane monohydrate. These results show that Tenebrio molitor extract is potential to be used as an Anti-Diabetic agent. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetes" title="diabetes">diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=extraction" title=" extraction"> extraction</a>, <a href="https://publications.waset.org/abstracts/search?q=Tenebrio%20molitor" title=" Tenebrio molitor"> Tenebrio molitor</a>, <a href="https://publications.waset.org/abstracts/search?q=traditional%20medicine" title=" traditional medicine"> traditional medicine</a> </p> <a href="https://publications.waset.org/abstracts/41077/dose-determination-of-tenebrio-molitor-mealworm-extract-as-an-anti-diabetic-agent" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/41077.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">429</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=diabetic%20wound&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=diabetic%20wound&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=diabetic%20wound&page=4">4</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=diabetic%20wound&page=5">5</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=diabetic%20wound&page=6">6</a></li> <li class="page-item"><a class="page-link" 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