CINXE.COM

<!doctype html> <html lang="en"> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <title>Cancer Metabolism and Redox Homeostasis of Oxidative Phosphorylat</title> <meta name="keywords" content="Cancer, Homeostasis, Phosphorylation,"> <meta name="description" content="Cancer Metabolism and Redox Homeostasis of Oxidative Phosphorylation in Cancer Metabolism, Karen Wetherall*.. "/> <meta name="citation_publisher" content="Longdom Publishing S.L"/> <meta name="citation_journal_title" content="Global Journal of Life Sciences and Biological Research"> <meta name="citation_title" content="Cancer Metabolism and Redox Homeostasis of Oxidative Phosphorylation in Cancer Metabolism"> <meta name="citation_author" content="Karen Wetherall"/> <meta name="citation_year" content="2024"> <meta name="citation_volume" content="10"> <meta name="citation_issue" content="2"> <meta name="citation_doi" content="10.35248/2456-3102.24.10.072"> <meta name="citation_issn" content="2456-3102"> <meta name="citation_publication_date" content="2024/06/17"/> <meta name="citation_firstpage" content="1"> <meta name="citation_lastpage" content="2"> <meta name="citation_abstract" content=""> <meta name="citation_fulltext_html_url" content="https://www.longdom.org/articles/cancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html"> <meta name="citation_pdf_url" content="https://www.longdom.org/articles/cancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism.pdf"> <meta name="format-detection" content="telephone=no" /> <meta name="google-site-verification" content="NomPTP94YozsgvD3NEFpNqUfY88e0TU0L64zNzZTpd0" /> <meta itemprop="name" content="longdom" /> <meta http-equiv="X-UA-Compatible" content="IE=edge" /> <meta name="ROBOTS" content="INDEX,FOLLOW" /> <meta name="googlebot" content="INDEX,FOLLOW" /> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no" /> <link rel="canonical" href="https://www.longdom.org/articles/cancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html" /> <link rel="alternate" href="https://www.longdom.org/articles/cancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html" hreflang="en-us" /> <script type="application/ld+json"> { "@context": "https://schema.org", "@type": "Organization", "url": "https://www.longdom.org/articles/cancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html", "logo": "https://www.longdom.org/assets/img/longdom-logo.svg" } </script>  <link rel="stylesheet" href="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/css/bootstrap.min.css" /> <link href="/assets/css/longdom.css" rel="stylesheet" /> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/animate.css/3.7.0/animate.min.css" />  <link rel="stylesheet" href="https://use.fontawesome.com/releases/v5.7.1/css/all.css" /> <link rel="stylesheet" href="https://maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" />   <link href="/assets/css/ionicons.min.css" rel="stylesheet" />  <link rel="stylesheet" href="/assets/css/jquery.mCustomScrollbar.min.css" /> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/bootstrap-select/1.13.2/css/bootstrap-select.min.css" />  <link rel="stylesheet" href="/assets/css/global.css" />  <link rel="stylesheet" href="/assets/css/styles.css" /> <link rel="stylesheet" type="text/css" href="/assets/css/author.css" /> <link rel="icon" href="/assets/img/favicon.png" type="image/gif" /> <link rel="stylesheet" href="/assets/css/coolautosuggest.css" />   <script async src="https://www.googletagmanager.com/gtag/js?id=G-LE7WH45F9C"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-LE7WH45F9C'); </script> <meta property="og:title" content="Longdom Publishing SL | Open Access Journals" /> <meta property="og:site_name" content="Longdom" /> <meta property="og:url" content="https://www.longdom.org/" /> <meta property="og:description" content="Longdom Publishing SL is one of the leading international open access journals publishers, covering clinical, medical, and technology-oriented subjects" /> <meta property="og:type" content="article" /> <meta property="og:image" content="https://www.longdom.org/assets/img/longdom-logo.svg" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:site" content="@org_longdom" /> <meta name="twitter:title" content="Longdom Publishing SL | Open Access Journals" /> <meta name="twitter:description" content="Longdom Publishing SL is one of the leading international open access journals publishers, covering clinical, medical, and technology-oriented subjects." /> <meta name="twitter:image" content="https://www.longdom.org/assets/img/longdom-logo.svg" />  <script> !function(f,b,e,v,n,t,s){if(f.fbq)return;n=f.fbq=function(){n.callMethod? n.callMethod.apply(n,arguments):n.queue.push(arguments)};if(!f._fbq)f._fbq=n; n.push=n;n.loaded=!0;n.version='2.0';n.queue=[];t=b.createElement(e);t.async=!0; t.src=v;s=b.getElementsByTagName(e)[0];s.parentNode.insertBefore(t,s)}(window, document,'script','//connect.facebook.net/en_US/fbevents.js'); fbq('init', '297919997051754'); fbq('track', "PageView"); </script>  <script type="text/javascript"> function openimage( theURL, winName, features ) { window.open( theURL, winName, features ); } </script> </head> <body> <header>  <nav class="navbar navbar-expand-lg navbar-light bg-white shadow-sm deva541"> <div class="container"> <a class="navbar-brand" href="https://www.longdom.org/" title="Longdom Publishing S.L"> <img src="/assets/img/longdom-logo.svg" alt="" height="25"> </a> <button class="navbar-toggler" type="button" data-toggle="collapse" data-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="collapse navbar-collapse justify-content-end" id="navbar"> <div class="navbar-nav"> <a class="nav-item nav-link" href="https://www.longdom.org/" title="Home">Home</a> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="Guidelines" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">Journals</a> <div class="dropdown-menu" aria-labelledby="Journals"> <a class="dropdown-item" href="https://www.longdom.org/journals-by-title.html" title="A-Z Journals">A-Z Journals</a> <a class="dropdown-item" href="https://www.longdom.org/open-access-journals-list.html" title="Browse By Subject">Browse By Subject</a> </div> </div> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="Guidelines" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">Guidelines & Policies </a> <div class="dropdown-menu" aria-labelledby="Guidelines"> <a class="dropdown-item" href="https://www.longdom.org/editorial-policies.html" title="Editorial Policies">Editorial Policies</a> <a class="dropdown-item" href="https://www.longdom.org/submit-manuscript.html" title="Online Submission">Online Submission</a> <a class="dropdown-item" href="https://www.longdom.org/instructions-to-authors.html" title="Instructions to Authors">Instructions to Authors</a> <a class="dropdown-item" href="https://www.longdom.org/policies.html" title="Policies">Policies</a> <a class="dropdown-item" href="https://www.longdom.org/publication-ethics.html" title="Publication ethics & malpractice statement">Publication ethics & malpractice statement</a> <a class="dropdown-item" href="https://www.longdom.org/reviewers.html" title="Reviewers">Reviewers</a> <a class="dropdown-item" href="https://www.longdom.org/terms-conditions.html" title="Terms and Conditions">Terms and Conditions</a> </div> </div> <a class="nav-item nav-link" href="https://www.longdom.org/advertising.html" title="Advertising">Advertising</a> <a class="nav-item nav-link" href="https://www.longdom.org/conferences.html" title="Conferences">Conferences</a> <a class="nav-item nav-link" href="https://www.longdom.org/contact-us.html" title="Contact us">Contact us</a> <div id="google_translate_element"></div> </div>  </div> </div> </nav> </header>  <section class="bg-info py-1"> <div class="container"> <div class="row align-items-center justify-content-between">  <div class="col-12 col-sm-3 "> <img src="https://www.longdom.org/admin/headers/global-journal-of-life-sciences-and-biological-research-logo.PNG" alt="Global Journal of Life Sciences and Biological Research" class="img-fluid mx-auto" width="105" height="105" /> </div> <div class="col-12 col-sm-7"> <h1 class="text-left text-white border-light-blue-200-before font-size-7">Global Journal of Life Sciences and Biological Research<br><small class="float-right font-size-5">Open Access</small></h1> </div>  <div class="col-12 col-sm-2 d-none d-sm-block"> <p class="lead">ISSN: 2456-3102</p>  <div id="feedback" class="card card-body p-1 font-size-2 shadow-sm z-index-1"> <div class="reach-us-animated"></div> <p class="card-text"><img src="/assets/img/whatsapp.svg" alt="" width="20" class="ml-2"> +44-77-2385-9429</p> </div> </div> </div> </div> </section>  <nav id="sticky-navbar" class="navbar navbar-expand-lg navbar-dark bg-primary py-0"> <div class="container"> <button class="navbar-toggler" type="button" data-toggle="collapse" data-target="#jrnlNavbar" aria-controls="jrnlNavbar" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="collapse navbar-collapse justify-content-center" id="jrnlNavbar"> <div class="navbar-nav"> <a class="nav-item nav-link " href="https://www.longdom.org/global-journal-life-sciences-biological-research.html" title="Journal Home">Journal Home</a> <a class="nav-link " href="https://www.longdom.org/global-journal-life-sciences-biological-research/editorial-team.html" title="Editorial Board">Editorial Board</a> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle " title="Instructions for Authors" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false" href="#">Instructions for Authors <i class="fas fa-caret-down"></i></a> <div class="dropdown-menu" aria-labelledby="EditorialPanel"> <a class="dropdown-item" href="https://www.longdom.org/global-journal-life-sciences-biological-research/instructionsforauthors.html" title="Instructions for Authors">Instructions for Authors</a>  <a class="dropdown-item" href="https://www.longdom.org/global-journal-life-sciences-biological-research/ethical-malpractices.html" title="Publication ethics & malpractice statement">Publication ethics & malpractice statement</a> </div> </div> <a class="nav-link " href="https://www.longdom.org/global-journal-life-sciences-biological-research/submissions.html" title="Submit Manuscript">Submit Manuscript</a> <a class="nav-link " href="https://www.longdom.org/global-journal-life-sciences-biological-research/aim-and-scope.html" title="Aims and Scope">Aims and Scope</a> <a class="nav-link " href="https://www.longdom.org/global-journal-life-sciences-biological-research/inpress.html" title="Articles in process">Articles in process</a>  <a class="nav-link " href="https://www.longdom.org/global-journal-life-sciences-biological-research/archive.html" title="Archive">Archive</a> <a class="nav-item nav-link " href="https://www.longdom.org/global-journal-life-sciences-biological-research/contact-us.html" title="Contact">Contact</a> </div> </div> </div> </nav> <script type="text/javascript"> function googleTranslateElementInit() { new google.translate.TranslateElement({pageLanguage: 'en'}, 'google_translate_element'); } </script> <script type="text/javascript" src="//translate.google.com/translate_a/element.js?cb=googleTranslateElementInit"></script> <section class="py-4 content"> <div class="container"> <div class="row"> <aside class="col-12 col-sm-3 order-last order-sm-first"> <a href="https://www.longdom.org/global-journal-life-sciences-biological-research/awards-nomination.html" class="btn btn-info btn-block mb-3 border-0 border-left-4 border-info font-size-4"><i class="fa-light fa-award-simple"></i> Awards Nomination </a> <a href="https://www.longdom.org/global-journal-life-sciences-biological-research-online-visitors-readers-198.html" class="btn btn-warning btn-block mb-3 border-0 border-left-4 border-info font-size-4"><i class="fas fa-book-reader"></i> 25+ Million Readerbase</a>  <div class="card shadow-sm sidebar mb-3"> <div class="list-group list-group-flush qr_code_image"> <img title="QR" src="https://chart.googleapis.com/chart?chs=185x185&cht=qr&chl=https%3A%2F%2Fwww.longdom.org%2Farticles%2Fcancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html&chld=M|0&icqrf=00b1e4" alt="Longdom"/>  <nav class="nav nav-pills social-icons-footer sidebar_social_icons a-pl-0"> <a title="Share This Article" target="_blank" class="nav-link" rel="noopener" href="https://www.facebook.com/sharer.php?s=100&p[title]=Cancer Metabolism and Redox Homeostasis of Oxidative Phosphorylation in Cancer Metabolism&p[url]=https%3A%2F%2Fwww.longdom.org%2Farticles%2Fcancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html"><img src="https://www.longdom.org/assets/socials/facebook.png" alt="Longdom" /></a> <a title="Share This Article" target="_blank" class="nav-link" rel="noopener" href="https://web.whatsapp.com/send?text=https%3A%2F%2Fwww.longdom.org%2Farticles%2Fcancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html" title="Share This Article" target="_blank" class="nav-link"><img src="https://www.longdom.org/assets/socials/whatsapp.png" alt="Longdom"/></a> <a title="Share This Article" target="_blank" class="nav-link" rel="noopener" href="https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fwww.longdom.org%2Farticles%2Fcancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html" title="Share This Article" target="_blank" class="nav-link"><img src="https://www.longdom.org/assets/socials/linkedin.png" alt="Longdom"/></a> <a title="Share This Article" target="_blank" class="nav-link" rel="noopener" href="https://twitter.com/share?text=Cancer Metabolism and Redox Homeostasis of Oxidative Phosphorylation in Cancer Metabolism&url=https%3A%2F%2Fwww.longdom.org%2Farticles%2Fcancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html" class="nav-link"><img src="https://www.longdom.org/assets/socials/twitter.png" alt="Longdom" /></a> </nav>  </div> </div>     <h6><a target="_blank" href="https://scholar.google.com/citations?hl=en&view_op=list_works&authuser=2&gmla=AL3_zihbjOi14yHjEKPsLLGqNdIpJ4MOkYn-gDBwXA1mTBP3Uh12UB3INfMMLsG_iLM_yIn09y8jTTRf77L2NR_sVqPE&user=upcpyDcAAAAJ" title="Click here">Google Scholar citation report</a></h6> <h6 style="font-weight:bold;">Citations : 317</h6> <p><a target="_blank" href="https://scholar.google.com/citations?hl=en&view_op=list_works&authuser=2&gmla=AL3_zihbjOi14yHjEKPsLLGqNdIpJ4MOkYn-gDBwXA1mTBP3Uh12UB3INfMMLsG_iLM_yIn09y8jTTRf77L2NR_sVqPE&user=upcpyDcAAAAJ" title="Click here">Global Journal of Life Sciences and Biological Research received 317 citations as per Google Scholar report</a></p> <div class="card shadow-sm sidebar mb-3"> <a href="https://www.longdom.org/global-journal-life-sciences-biological-research/citations.html" title="Click here"><img src="https://www.longdom.org/admin/citation-images/global-journal-of-life-sciences-and-biological-research-citation.png" alt="Citation" class="img-fluid p_rel" /></a> </div>   <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header pr-0">Indexed In</h6> <div class="list-group list-group-flush overflow-view"> <div class="list-group-item p-0 pt-2 pl-2"> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> Euro Pub </div> <div class="list-group-item p-0 pt-2 pl-2"> <i class="fa fa-chevron-right" style="font-size: 11px;color: #0056b3;"></i> Google Scholar </div> </div> <p class="m-0 clearfix"><a href="https://www.longdom.org/global-journal-life-sciences-biological-research/indexing.html" title="Click here"><span class="btn btn-warning btn-xs float-right">View More »</span></a></p> </div>   <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header">Useful Links</h6> <div class="card-body p-0"> <nav class="nav flex-column font-size-3 icon-list icon-list-angle-right a-py-1"> <a class="nav-item nav-link" href="https://www.longdom.org/covid-19-peer-reviewed-journals-articles-special-issues.html" title="Click Here">Covid-19 Journal Articles Issues</a> <a class="nav-item nav-link" href="https://www.longdom.org/global-journal-life-sciences-biological-research/aim-and-scope.html" title="Click Here">Aim and Scope</a> <a class="nav-item nav-link" href="https://www.longdom.org/global-journal-life-sciences-biological-research/peer-review-process.html" title="Click Here">Peer Review Process</a> <a class="nav-item nav-link" href="https://www.longdom.org/global-journal-life-sciences-biological-research/other-comments.html" title="Click Here">Other Comments</a> <a class="nav-item nav-link" href="https://www.longdom.org/global-journal-life-sciences-biological-research/advertising.html" title="Click Here">Advertising</a> <a class="nav-item nav-link" href="https://www.longdom.org/global-journal-life-sciences-biological-research/citations.html" title="Click Here">Citations Report</a> <a class="nav-item nav-link" href="https://www.longdom.org/global-journal-life-sciences-biological-research/indexing.html" title="Click Here">Indexing and Archiving</a> <a class="nav-item nav-link" href="https://www.longdom.org/global-journal-life-sciences-biological-research/archive.html" title="Click Here">Table of Contents</a> <a class="nav-item nav-link" href="https://www.longdom.org/submissions/global-life-sciences-biological-research.html" title="Click Here">Submit Paper</a> <a class="nav-item nav-link" href="https://www.longdom.org/editorial-tracking/" title="Click Here">Track Your Paper</a> <a class="nav-item nav-link" href="https://www.longdom.org/funded-articles.html" title="Click Here">Funded Work</a> </nav> </div> </div>  <div class="card shadow-sm sidebar mb-3" style="margin-top:10px"> <h6 class="card-header">Share This Page</h6> <div class="card-body"> <nav class="nav social-icons social-icons-sm"> <a class="nav-link bg-facebook white" href="https://www.facebook.com/sharer.php?u=https://www.longdom.org/articles/cancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html" target="_blank" title="Share with Facebook" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link bg-twitter white" href="https://twitter.com/share?url=https://www.longdom.org/articles/cancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html" rel="noopener" target="_blank" title="Share with Twitter"><i class="fab fa-twitter"></i></a> <a class="nav-link bg-linkedin white" href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.longdom.org/articles/cancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html" rel="noopener" target="_blank" title="Share with Linkdin"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link bg-googleplus white" href="https://plus.google.com/share?url=https://www.longdom.org/articles/cancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html" target="_blank" rel="noopener" title="Share with Google+"><i class="fab fa-google-plus-g"></i></a> <a class="nav-link bg-pinterest white" href="https://pinterest.com/pin/create/button/?url=https://www.longdom.org/articles/cancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html" rel="noopener" target="_blank" title="Share with Pintrest"><i class="fab fa-pinterest-p"></i></a> <a class="nav-link bg-blogger white" href="https://www.blogger.com/blog-this.g?u=https://www.longdom.org/articles/cancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism-109649.html" rel="noopener" target="_blank" title="Share with Blogger"><i class="fab fa-blogger-b"></i></a> </nav> </div> </div>  <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header">Recommended Journals</h6> <div class="card-body p-0"> <nav class="nav flex-column font-size-3 icon-list icon-list-angle-right a-py-1"> <a class="nav-item nav-link" href="https://www.longdom.org/endocrinology-metabolic-syndrome.html" title="Click Here">Endocrinology Journal</a> <a class="nav-item nav-link" href="https://www.longdom.org/applied-microbiology.html" title="Click Here">Microbiology Journal</a> <a class="nav-item nav-link" href="https://www.longdom.org/genetic-syndromes-gene-therapy.html" title="Click Here">Genetics journal</a> </nav> </div> </div>  <div class="card shadow-sm sidebar mb-3"> <a href="https://www.longdom.org/global-journal-life-sciences-biological-research/advertising.html" title="Click here"><img src="https://www.longdom.org/assets/img/tower-banner.jpg" alt="Flyer image" class="img-fluid p_rel" /> <span class="p_abo cu_roundchip"> <span> <h5><span>25+</span> Million Website Visitors</h5> </span> </span> </a> </div>    <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header">Journal Flyer</h6> <img src="https://www.longdom.org/admin/flyers/global-journal-of-life-sciences-and-biological-research-flyer.jpg" alt="Global Journal of Life Sciences and Biological Research" class="img-fluid"/> </div>   <div class="sidebar pt-20 pl-10 mt-xs-0" align="center"> <a class="twitter-timeline" href="https://twitter.com/globaljournalof" data-width="450" data-height="300">Tweets by globaljournalof</a> <script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script> </div> <div class="clear"> </div>   <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header">Open Access Journals</h6> <div class="card-body p-0 scroll_mang"> <nav class="nav flex-column font-size-3 icon-list icon-list-angle-right a-py-1"> <a class="nav-item nav-link" href="https://www.longdom.org/agri-and-aquaculture-journals.html" title="Click Here">Agri and Aquaculture</a> <a class="nav-item nav-link" href="https://www.longdom.org/biochemistry-journals.html" title="Click Here">Biochemistry</a> <a class="nav-item nav-link" href="https://www.longdom.org/bioinformatics-and-systems-biology-journals.html" title="Click Here">Bioinformatics & Systems Biology</a> <a class="nav-item nav-link" href="https://www.longdom.org/business-and-management-journals.html" title="Click Here">Business & Management</a> <a class="nav-item nav-link" href="https://www.longdom.org/chemistry-journals.html" title="Click Here">Chemistry</a> <a class="nav-item nav-link" href="https://www.longdom.org/clinical-sciences-journals.html" title="Click Here">Clinical Sciences</a> <a class="nav-item nav-link" href="https://www.longdom.org/engineering-journals.html" title="Click Here">Engineering</a> <a class="nav-item nav-link" href="https://www.longdom.org/food-and-nutrition-journals.html" title="Click Here">Food & Nutrition</a> <a class="nav-item nav-link" href="https://www.longdom.org/general-science-journals.html" title="Click Here">General Science</a> <a class="nav-item nav-link" href="https://www.longdom.org/genetics-and-molecular-biology-journals.html" title="Click Here">Genetics & Molecular Biology</a> <a class="nav-item nav-link" href="https://www.longdom.org/immunology-and-microbiology-journals.html" title="Click Here">Immunology & Microbiology</a> <a class="nav-item nav-link" href="https://www.longdom.org/medical-sciences-journals.html" title="Click Here">Medical Sciences</a> <a class="nav-item nav-link" href="https://www.longdom.org/neuroscience-and-psychology-journals.html" title="Click Here">Neuroscience & Psychology</a> <a class="nav-item nav-link" href="https://www.longdom.org/nursing-and-health-care-journals.html" title="Click Here">Nursing & Health Care</a> <a class="nav-item nav-link" href="https://www.longdom.org/pharmaceutical-sciences-journals.html" title="Click Here">Pharmaceutical Sciences</a> </nav> </div> </div>  </aside> <div class="col-12 col-sm-9 full-text"> <div class="row align-items-center justify-content-between"> <div class="col-12 col-sm-4"> <p class="text-muted mb-0"> Commentry - (2024)Volume 10, Issue 2 </p> </div> <div class="col-12 col-sm-8 text-right custom-column"> <a href="https://www.longdom.org/articles/cancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism.pdf" title="View PDF" class="btn btn-sm bg-green-600 rounded-50"><i class="fas fa-file-pdf"></i> View PDF</a> <a href="https://www.longdom.org/pdfdownload.php?download=articles/cancer-metabolism-and-redox-homeostasis-of-oxidative-phosphorylation-in-cancer-metabolism.pdf&aid=109649" title="Download PDF" class="btn btn-sm bg-green-600 rounded-50"><i class="fas fa-download"></i> Download PDF</a> </div> </div> <h2 class="font-size-7 mt-2">Cancer Metabolism and Redox Homeostasis of Oxidative Phosphorylation in Cancer Metabolism</h2> <a href='https://www.longdom.org/author/karen-wetherall-71642' title='Karen Wetherall' style='color:#555; border-bottom:1px dotted #CCC;'>Karen Wetherall</a><sup><a href='#Karen_Wetherall'>*</a></sup> <div> </div> <a id="Karen_Wetherall"></a> <strong><sup>*</sup>Correspondence:</strong> Karen Wetherall, Department of Oncology, Juntendo University, Tokyo, Japan, <strong>Email:</strong> <i class='fa fa-envelope' aria-hidden='true' title='wetherkar@tokyo.ac.jp'></i> <p><a href="#ai"><strong>Author info »</strong></a></p> <h4>About the Study</h4> <p>The process of oxidative phosphorylation is fundamental to the synthesis of cellular energy and is deeply ingrained in the metabolism of all aerobic organisms. This fundamental biochemical process occurs within the mitochondria, where electrons extracted from nutrients during cellular respiration cascade through a series of electron transport chain complexes. These complexes, embedded within the inner mitochondrial membrane, generate a proton gradient that drives ATP synthesis <em>via</em> ATP synthase a molecular machine often likened to a cellular turbine.</p> <p>Beyond its role in ATP production, oxidative phosphorylation represents a marvel of biological efficiency and complexity. It not only sustains essential cellular functions but also integrates closely with cellular signaling, redox regulation, and metabolic adaptation. Dysregulation of oxidative phosphorylation underpins numerous human diseases, underscoring its indispensable role in health and disease. Understanding the complex of this process illuminates pathways for therapeutic interventions targeting mitochondrial dysfunction, offering potential methods to address a wide array of metabolic disorders and age-related conditions.</p> <p><strong>Oxidative phosphorylation in <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-26169.html'>cancer</a> metabolism</strong></p> <p>Its undergoes significant alterations that support the rapid proliferation and survival of <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-26169.html'>cancer</a> cells. While normal <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cells-53612.html'>cells</a> primarily rely on oxidative phosphorylation for ATP production, many <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-26169.html'>cancer</a> <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cells-53612.html'>cells</a> exhibit a metabolic shift towards increased glycolysis, known as the Warburg effect, even in the presence of oxygen a phenomenon termed aerobic glycolysis. Despite this preference for glycolysis, <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-26169.html'>cancer</a> <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cells-53612.html'>cells</a> often maintain functional oxidative phosphorylation, which plays important roles in supplying metabolic intermediates, supporting redox balance, and sustaining cellular bioenergetics under varying conditions within the tumor microenvironment.</p> <p>The dysregulation of oxidative phosphorylation in <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-26169.html'>cancer</a> metabolism is complex and varies depending on tumor type and stage. These metabolic adaptations are important for developing targeted therapies that exploit vulnerabilities in <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-26169.html'>cancer</a> cell metabolism while minimizing effects on normal cells, potentially offering new methods for improving <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-26169.html'>cancer</a> treatment strategies.</p> <p><strong>Oxidative phosphorylation and cellular redox homeostasis</strong></p> <p>Oxidative phosphorylation is complex linked to cellular redox homeostasis, maintaining a delicate balance between oxidation and reduction reactions essential for cellular function and survival. As electrons pass through the electron transport chain in mitochondria, they generate a proton gradient that drives ATP synthesis. Simultaneously, this process produces Reactive Oxygen <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/species-5796.html'>Species</a> (ROS) as natural biproducts.</p> <p>Cellular redox <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/homeostasis-25780.html'>homeostasis</a> involves complex antioxidant defense systems that regulate ROS levels to prevent oxidative damage while utilizing ROS as signaling molecules in cellular processes. Oxidative phosphorylation influences redox balance by controlling the production and <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/detoxification-15599.html'>detoxification</a> of ROS, thereby impacting cell signaling, metabolism, and stress response pathways.</p> <p>Disruptions in oxidative phosphorylation can lead to oxidative stress, characterized by an imbalance between ROS production and antioxidant defenses, contributing to cellular damage and various diseases. Understanding the exchange between oxidative phosphorylation and redox <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/homeostasis-25780.html'>homeostasis</a> is need for deciphering disease mechanisms and developing therapeutic strategies aimed at maintaining cellular health and preventing oxidative damage.</p> <p><strong>Impact of <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/oxidative-stress-2345.html'>oxidative stress</a> on mitochondrial electron transport chain</strong></p> <p>The Electron Transport Chain (ETC) within the mitochondria is significantly impacted by oxidative stress, the primary site of cellular energy production and Reactive Oxygen <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/species-5796.html'>Species</a> (ROS) generation. Elevated ROS levels, arising from conditions such as environmental toxins, metabolic imbalance, or inflammatory responses, can damage mitochondrial components necessary for ETC function, including lipids, proteins, and DNA.</p> <p>Such damage disrupts electron flow within the ETC, impairing ATP production and exacerbating ROS production in a harmful cycle. Additionally, ROS-induced modifications to ETC <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/enzymes-9819.html'>enzymes</a> can further compromise their efficiency, leading to cellular dysfunction and contributing to various diseases, including neurodegenerative disorders, cardiovascular diseases, and <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/cancer-3081.html'>cancer.</a> The impact of <a target='_blank' href='https://www.longdom.org/peer-reviewed-journals/oxidative-stress-2345.html'>oxidative stress</a> on the ETC is important for developing strategies to mitigate ROS-induced damage, restore mitochondrial function, and maintain cellular homeostasis. Research into antioxidant therapies and mitochondrial-targeted interventions aims to counteract these effects, offering potential methods for therapeutic development against oxidative stressrelated diseases.   <div class="card bg-light mb-3"> <div class="card-body px-3 pb-0"> <h4 class="font-size-4"><a id="ai"></a>Author Info</h4> <a href='https://www.longdom.org/author/karen-wetherall-71642' title='Karen Wetherall' style='color:#555; border-bottom:1px dotted #CCC;'>Karen Wetherall</a><sup><a href='#Karen_Wetherall'>*</a></sup> <div> </div> Department of Oncology, Juntendo University, Tokyo, Japan<br> <div> </div> <p><strong>Citation:</strong> Wetherall K (2024) Cancer Metabolism and Redox Homeostasis of Oxidative Phosphorylation in Cancer Metabolism. Glob J Lif Sci Biol Res. 10:072.</p> <p> <strong>Received: </strong>15-May-2024, Manuscript No. GJLSBR-24-33086; <strong>Editor assigned: </strong>20-May-2024, Pre QC No. GJLSBR-24-33086 (PQ); <strong>Reviewed: </strong>03-Jun-2024, QC No. GJLSBR-24-33086; <strong>Revised: </strong>10-Jun-2024, Manuscript No. GJLSBR-24-33086 (R); <strong>Published:</strong> 17-Jun-2024 , DOI: 10.35248/2456-3102.24.10.072</p> <p><strong>Copyright: </strong>© 2024 Wetherall K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</p> </div> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Content Links</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://www.longdom.org/online-tools.html" title="Click here">Tools</a> </li> <li><a class="" href="https://www.longdom.org/feedback.html" title="Click here">Feedback</a></li> <li><a class="" href="https://www.longdom.org/careers.html" title="Click here">Careers</a></li> <li><a class="" href="https://www.longdom.org/privacy-policy.html" title="Click here">Privacy Policy</a></li> <li><a class="" href="https://www.longdom.org/terms-conditions.html" title="Click here">Terms & Conditions</a></li> <li><a class="" href="https://www.longdom.org/authors-reviewers-editors.html" title="Click here">Authors, Reviewers & Editors</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Contact Longdom</h4> <p>Longdom Group SA<br> Avenue Roger Vandendriessche,<br> 18, 1150 Brussels, Belgium<br> Phone: +442038085340 <br><strong>Email:</strong> <a href="mailto:info@longdom.org" class="white" title="Click here">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Connect</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="Click here" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i> Facebook</a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="Click here" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i> Linkedin</a> <a href="https://twitter.com/LongdomP" title="Click here" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i> Twitter</a> <a href="https://www.instagram.com/longdom_publisher/" title="Click here" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i> Instagram</a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>Copyright © 2025 <a href="https://www.longdom.org/" title="Click here" class="white">Longdom Publishing</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script defer src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script defer src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script defer src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? { 'position': 'fixed', 'top': '440px' } : { 'position': 'absolute', 'top': '440px' } ); return fix_element; }()); }); </script>   <script defer src="https://unpkg.com/feather-icons"></script> <script> feather.replace() </script>  <script defer src="/assets/js/scroll-to-top.js"></script>  <script defer type="text/javascript" src="/assets/js/coolautosuggest.js"></script> <script language="javascript" type="text/javascript"> $("#keyword").coolautosuggest({ url: "https://www.longdom.org/author-names.php?chars=", minChars: 3, }); </script> <script defer src="/assets/js/jquery.mCustomScrollbar.concat.min.js"></script> <script> // Scrollbar var Scrollbar = function() { "use strict"; // Handle Scrollbar Linear var handleScrollbarLinear = function() { $(".scrollbar").mCustomScrollbar({ theme: "minimal-dark" }); } return { init: function() { handleScrollbarLinear(); // initial setup for scrollbar linear } } }(); $(document).ready(function() { Scrollbar.init(); }); /*========================== Stikcy Navbar ============================*/ window.onscroll = function() { myFunction() }; var navbar = document.getElementById("sticky-navbar"); var sticky = navbar.offsetTop; function myFunction() { if (window.pageYOffset >= sticky) { navbar.classList.add("sticky") } else { navbar.classList.remove("sticky"); } } /*========================== Bootstrap Popover ============================*/ $(function () { $('[data-toggle="popover"]').popover() }) </script>  <script defer src="/assets/js/jquery.malihu.PageScroll2id.min.js"></script> <script> (function($){ $(window).on("load",function(){ $("a[rel='m_PageScroll2id']").mPageScroll2id(); }); })(jQuery); </script>  <script defer type="text/javascript" src="/assets/js/jquery.matchHeight-min.js"></script> <script> $(function() { $('.match-height').matchHeight({ byRow: true, property: 'height', target: null, }); }); </script> <script defer type="text/javascript" src="/assets/js/grids.min.js"></script> <script type="text/javascript"> // Equal Height var EqualHeight = function() { "use strict"; // Handle Equal Height var handleEqualHeight = function() { $(function($) { $('.equal-height').responsiveEqualHeightGrid(); }); } return { init: function() { handleEqualHeight(); // initial setup for equal height } } }(); $(document).ready(function() { EqualHeight.init(); }); </script>  <script defer src="https://cdnjs.cloudflare.com/ajax/libs/bootstrap-select/1.13.2/js/bootstrap-select.min.js"></script> <script> $('.selectpicker').selectpicker(); </script> <script> $(document).ready(function(){ var filecount = 1; $('.filerowclass').each(function(){ var countattr = $(this).attr('countattr'); if(filecount == countattr){ var countlink = $('#rowfile'+countattr+ ' .filelinkclass').length; if(countlink == 0){ $('#rowfile'+countattr).remove(); } } filecount++; }); }); </script>  <script type="text/javascript"> $(document).ready(function() { $("#wait").hide(); $("#jkeyword").keyup(function() { $("#wait").show(); //values of sending variables var jkeyword=$("#jkeyword").val(); var dataString = { 'jkeyword':jkeyword }; $.ajax ({ type: "POST", url: "https://www.longdom.org/journal-search.php", data: dataString, cache: false, success: function(html) { $("#jresult").html(html); $("#wait").hide(); } }); }); }); </script> <link href="https://cdn.jsdelivr.net/npm/select2@4.1.0-rc.0/dist/css/select2.min.css" rel="stylesheet" /> <script defer src="https://cdn.jsdelivr.net/npm/select2@4.1.0-rc.0/dist/js/select2.min.js"></script> </body> </html>