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width="1.25rem" xmlns="http://www.w3.org/2000/svg"><polyline points="6 9 6 2 18 2 18 9"></polyline><path d="M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2"></path><rect x="6" y="14" width="12" height="8"></rect></svg></a></button></div></div><div><div class="flex flex-wrap"><p class=" text-primary font-semibold">News</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1"></div><p class=" text-primary font-semibold">Article</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1 "></div><time class="text-gray-500 " dateTime="2024-11-07T16:00:00.000">November 7, 2024</time></div><h1 class="text-[26px] font-medium leading-8">Eque-Cel CAR T Shows Strong Results for Multiple Myeloma</h1><div class="py-3 text-gray-600 md:flex flex-col md:justify-between"><div class="flex flex-col xs:flex-row"><p class="mr-1 self-start">Author(s):</p><div class="flex flex-col xs:flex-row mb-3 md:mb-0"><div class="flex flex-wrap"><span class="text-md mr-2"><a class="text-author text-gray-500 hover:text-primary underline hover:no-underline decoration-gray-400" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></span></div></div></div><div class="max-w-full"><div class="flex flex-wrap sm:flex-nowrap items-center w-fit my-2"></div><div class="w-full flex flex-col sm:flex-row justify-between mt-2"><div class="block md:hidden "><div class="mt-2 flex items-center max-w-fit"><button title="Eque-Cel CAR T Shows Strong Results for Multiple Myeloma" aria-label="facebook" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#3b5998"></circle><path d="M34.1,47V33.3h4.6l0.7-5.3h-5.3v-3.4c0-1.5,0.4-2.6,2.6-2.6l2.8,0v-4.8c-0.5-0.1-2.2-0.2-4.1-0.2 c-4.1,0-6.9,2.5-6.9,7V28H24v5.3h4.6V47H34.1z" fill="white"></path></svg></button><button aria-label="twitter" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg fill="#DC7633" xmlns="http://www.w3.org/2000/svg" width="32" zoomAndPan="magnify" viewBox="0 0 375 374.9999" height="32" preserveAspectRatio="xMidYMid meet" version="1.0"><defs><path d="M 7.09375 7.09375 L 367.84375 7.09375 L 367.84375 367.84375 L 7.09375 367.84375 Z M 7.09375 7.09375 " fill="#000000"></path></defs><g><path d="M 187.46875 7.09375 C 87.851562 7.09375 7.09375 87.851562 7.09375 187.46875 C 7.09375 287.085938 87.851562 367.84375 187.46875 367.84375 C 287.085938 367.84375 367.84375 287.085938 367.84375 187.46875 C 367.84375 87.851562 287.085938 7.09375 187.46875 7.09375 " fill-opacity="1" fill-rule="nonzero" fill="#000000"></path></g><g transform="translate(85, 75)"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" version="1.1" height="215" width="215"><path d="M18.244 2.25h3.308l-7.227 8.26 8.502 11.24H16.17l-5.214-6.817L4.99 21.75H1.68l7.73-8.835L1.254 2.25H8.08l4.713 6.231zm-1.161 17.52h1.833L7.084 4.126H5.117z" fill="#ffffff"></path></svg> </g></svg></button><button aria-label="linkedin" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#007fb1"></circle><path d="M20.4,44h5.4V26.6h-5.4V44z M23.1,18c-1.7,0-3.1,1.4-3.1,3.1c0,1.7,1.4,3.1,3.1,3.1 c1.7,0,3.1-1.4,3.1-3.1C26.2,19.4,24.8,18,23.1,18z M39.5,26.2c-2.6,0-4.4,1.4-5.1,2.8h-0.1v-2.4h-5.2V44h5.4v-8.6 c0-2.3,0.4-4.5,3.2-4.5c2.8,0,2.8,2.6,2.8,4.6V44H46v-9.5C46,29.8,45,26.2,39.5,26.2z" fill="white"></path></svg></button><button title="Eque-Cel CAR T Shows Strong Results for Multiple Myeloma" aria-label="pinterest" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#cb2128"></circle><path d="M32,16c-8.8,0-16,7.2-16,16c0,6.6,3.9,12.2,9.6,14.7c0-1.1,0-2.5,0.3-3.7 c0.3-1.3,2.1-8.7,2.1-8.7s-0.5-1-0.5-2.5c0-2.4,1.4-4.1,3.1-4.1c1.5,0,2.2,1.1,2.2,2.4c0,1.5-0.9,3.7-1.4,5.7 c-0.4,1.7,0.9,3.1,2.5,3.1c3,0,5.1-3.9,5.1-8.5c0-3.5-2.4-6.1-6.7-6.1c-4.9,0-7.9,3.6-7.9,7.7c0,1.4,0.4,2.4,1.1,3.1 c0.3,0.3,0.3,0.5,0.2,0.9c-0.1,0.3-0.3,1-0.3,1.3c-0.1,0.4-0.4,0.6-0.8,0.4c-2.2-0.9-3.3-3.4-3.3-6.1c0-4.5,3.8-10,11.4-10 c6.1,0,10.1,4.4,10.1,9.2c0,6.3-3.5,11-8.6,11c-1.7,0-3.4-0.9-3.9-2c0,0-0.9,3.7-1.1,4.4c-0.3,1.2-1,2.5-1.6,3.4 c1.4,0.4,3,0.7,4.5,0.7c8.8,0,16-7.2,16-16C48,23.2,40.8,16,32,16z" fill="white"></path></svg></button><button aria-label="email" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#7f7f7f"></circle><path d="M17,22v20h30V22H17z M41.1,25L32,32.1L22.9,25H41.1z M20,39V26.6l12,9.3l12-9.3V39H20z" fill="white"></path></svg></button><a class="print-wrap flex justify-center items-center cursor-pointer"><svg id="print" xmlns="http://www.w3.org/2000/svg" width="24" height="24" fill="currentColor" class="print bi bi-printer" viewBox="0 0 16 16"> <path d="M2.5 8a.5.5 0 1 0 0-1 .5.5 0 0 0 0 1z"></path> <path d="M5 1a2 2 0 0 0-2 2v2H2a2 2 0 0 0-2 2v3a2 2 0 0 0 2 2h1v1a2 2 0 0 0 2 2h6a2 2 0 0 0 2-2v-1h1a2 2 0 0 0 2-2V7a2 2 0 0 0-2-2h-1V3a2 2 0 0 0-2-2H5zM4 3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1v2H4V3zm1 5a2 2 0 0 0-2 2v1H2a1 1 0 0 1-1-1V7a1 1 0 0 1 1-1h12a1 1 0 0 1 1 1v3a1 1 0 0 1-1 1h-1v-1a2 2 0 0 0-2-2H5zm7 2v3a1 1 0 0 1-1 1H5a1 1 0 0 1-1-1v-3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1z"></path></svg></a></div><style> .print-wrap { width: 32px; 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width: 35px; position: relative; left: 22px; bottom: 21px; } .rhap_volume-button { // width: 5px; // height: 5px; flex: 0 0 26px; position: relative; left: 22px; bottom: 21px; } .rhap_volume-button svg { height: 18px; width: 18px; } .rhap_volume-indicator { height: 8px; width: 8px; top: -2.75px } .rhap_button-clear { color: rgb(0,55,103) !important; } .rhap_play-pause-button { color: rgb(0,55,103) !important; font-size: 30px !important; width: 30px !important; height: 30px !important; position: relative; right: 90px; bottom: 22px; } .rhap_main-controls button { color: rgb(0,55,103) !important; } audio::-webkit-media-controls-play-button, video::-webkit-media-controls-play-button { -webkit-appearance: media-play-button; color: #b8dcf6; } audio::-webkit-media-controls-panel { background-color: white !important; color: #000; } audio::-webkit-media-controls-current-time-display, audio::-webkit-media-controls-time-remaining-display { font-size: 12px; } </style></div></div></div><div class=" lg:w-full flex flex-col lg:flex-row lg:items-center lg:justify-end"></div><div class="w-full flex flex-col px-4 py-4 border-t border-b border-solid border-gray-400 my-4 "><h3 class="text-primary text-xl font-semibold">Key Takeaways</h3><ul class="list-disc px-8"><li class="py-2 "> Equecabtagene autoleucel showed high efficacy in relapsed/refractory multiple myeloma, with a 96% overall response rate and 42.6% complete response rate at three months. </li><li class="py-2 "> Minimal residual disease negativity was achieved in 95% of patients, with a median time to this outcome of 15 days. </li><li class="py-2 hidden"> Adverse events were frequent, with neutropenia and cytokine release syndrome being the most common, necessitating infection prevention strategies. </li><li class="py-2 hidden"> The study emphasized the need for larger, more diverse trials with long-term follow-up to validate findings and assess broader applicability.</li></ul><span class="text-xs font-bold text-primary underline cursor-pointer mt-2 ml-4">SHOW MORE</span></div><p class="py-2 mb-2 text-sm italic text-gray-600">Multiple myeloma is the second most common hematologic malignancy, but there is a treatment gap for patients with disease progression following standard-of-care therapies that include immunomodulatory agents, proteasome inhibitors, and anti-CD38 antibodies.</p><div class="py-2"><div class="blockText_blockContent__TbCXh"><p class="pb-2">Equecabtagene autoleucel (eque-cel), an investigative fully human-derived B-cell maturation antigen (BCMA)–targeting chimeric antigen receptor (CAR) T-cell therapy directed against <a target="_blank" href="https://www.ajmc.com/compendium/multiple-myeloma">multiple myeloma</a>, has shown great promise in a new study conducted at 14 centers in China, with both CAR T–naive (88.3%) and CAR T–experienced (11.7%) patients showing benefit.</p><p class="pb-2"></p><p class="pb-2">Early, deep, and durable responses were seen among 103 patients who received a single treatment infusion at 1.0 x 10<sup class="text-inherit">6</sup> CAR-positive T cells/kg after lymphodepletion, as participants (N = 103) in the phase 1b/2 nonrandomized FUMANBA-1 trial (ChiCTR2000033946), according to results published online today in <a rel="nofollow noreferrer noopener" target="_blank" href="https://jamanetwork.com/journals/jamaoncology/fullarticle/2826068"><em>JAMA Oncology</em></a>.<sup class="text-inherit">1</sup><strong> </strong>All of the patients had received at least 3 prior lines of therapy, but not everyone had received prior CAR T. The primary outcome of interest of this analysis was efficacy, via overall response rate (ORR), and secondary outcomes of interest were safety, pharmacokinetics, and pharmacodynamics. Minimal residual disease (MRD) status was assessed at screening, baseline, and when patients achieved at least a very good partial response (PR) or disease progression. Study participants will be followed for at least 15 years for ongoing response monitoring.</p><p class="pb-2"></p><p class="pb-2">Other BCMA-directed therapies have proved effective against multiple myeloma, backed by results from several prominent trials: DREAMM-2 (NCT03525678),<sup class="text-inherit">2</sup> Cartitude-4,<sup class="text-inherit">3</sup> KarMMa-3,<sup class="text-inherit">4</sup> MajesTEC-1,<sup class="text-inherit">5</sup> and MagnetisMM-3.<sup class="text-inherit">6</sup><strong> </strong>However, more data are needed on human use of fully human-derived BCMA CAR T therapies such as eque-cel.</p><p class="pb-2"></p><p class="pb-2">Prior to receiving eque-cel, the patients underwent lymphodepletion with 500 mg/m<sup class="text-inherit">2</sup> of cyclophosphamide and 30 mg/m<sup class="text-inherit">2</sup> of fludarabine administered intravenously daily for 3 consecutive days. Most (53.4%) were male patients, and their median age was 58 (range, 39-70) years. All were Chinese. Among those who received bridging therapy (46.6%), 3 achieved a PR; 9 had a minor response; 22 had stable disease; and 14 experienced disease progression.</p><p class="pb-2"></p><p class="pb-2">The median follow-up was 13.8 (range, 0.4-27.2) months, and during this time, the ORR was 96%, and it was 99% among those naive to CAR T. Median time to first response of at least a PR was 16 (range, 11-179) days, and to best response, 92 (range, 14-557) days. At 3 months after CAR T infusion, the ORR remained high, at 94.1%, and 42.6% had achieved a complete response (CR) or a stringent CR (sCR). By the 12-month mark, the latter measure had jumped to 73.3%. Among the patients with no history of CAR T, the CR/sCR rate was 79%.</p><p class="pb-2"></p><div class=""><div style="width:40%;float:right;max-width:525px;margin:0 0 1.5rem 1.5rem;clear:both;cursor:" class=" figure"><div class="flex-none relative text-center"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%271200%27%20height=%27738%27/%3e"/></span><img alt="Neon CAR T graphic | Image Credit: © kalpis-stock.adobe.com" title="Neon CAR T graphic | Image Credit: © kalpis-stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="Neon CAR T graphic | Image Credit: © kalpis-stock.adobe.com" title="Neon CAR T graphic | Image Credit: © kalpis-stock.adobe.com" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fd6cda65715e52774e2cab34d922cdd302167b243-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1x, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fd6cda65715e52774e2cab34d922cdd302167b243-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 2x" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fd6cda65715e52774e2cab34d922cdd302167b243-1200x738.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div id="image-caption" class="text-gray-500 italic"><div class="blockText_blockContent__TbCXh"><p class="pb-2">In the FUMANBA-1 trial, 103 patients received a single infusion of 1.0 x 10<sup class="text-inherit">6</sup> CAR-positive T cells/kg after lymphodepletion, and benefits were seen in patients who had and had not received prior CAR T. | Image Credit: © kalpis-stock.adobe.com</p></div></div><div class="top-[-100%] block w-[1px] transition-opacity duration-500 ease-in-out opacity-0 overflow-hidden"><img class="m-auto absolute inset-0 max-w-[0%] max-h-[0%] border-[3px] border-solid border-white shadow-[0px_0px_8px_rgba(0,0,0,0.3)] box-border transition ease-in-out duration-500" src="https://cdn.sanity.io/images/0vv8moc6/ajmc/d6cda65715e52774e2cab34d922cdd302167b243-1200x738.jpg?fit=crop&auto=format"/></div></div><style> #image-caption p{ font-size: 12px; max-width: 525px; margin: 0 auto; text-align: center; } </style></div><p class="pb-2">There was also a very high MRD negativity rate of 95%, with a median time to this outcome of 15 (range, 14-186) days, with 8 patients sustaining this status for over 2 years. Also among those who achieved MRD negativity, the CR rate was 75% and the sCR rate was 42%.</p><p class="pb-2"></p><p class="pb-2">Median progression-free survival and overall survival were not reached, but at 12 months, these measures were 78.8% (95% CI, 68.6%-86.0%) and 92.2% (95% CI, 84.3%-96.2%). Further, in CAR T-cell therapy–naive patients, the ORR and PFS were superior compared with CAR T–experienced patients.</p><p class="pb-2"></p><p class="pb-2">Following the infusion, the median maximum copy number was 87,571 (range, 439-196,888 copies/μg DNA), and median time to maximum copy number was 12 (range, 0-23) days.</p><p class="pb-2"></p><p class="pb-2">Of the total patient cohort, 102 experienced adverse events (AEs), 94.2% of which were grade 3 or higher, and these included neutropenia (81.6%), leukopenia (74.8%), thrombocytopenia (59.2%), lymphopenia (59.2%), and anemia (51.5%). Cytokine release syndrome was also a common AE (grade 1/2, 92.2%; grade 4, 1%), at a median (IQR) duration of 5 (4-7) days and a median time to onset of 6 (4-7.5) days. Infection treatment-related serious AEs were seen in 32 patients, and 14 patients died.</p><p class="pb-2"></p><p class="pb-2">“The impaired humoral immunity, characterized by prolonged B-cell depletion and hypogammaglobulinemia, was a significant contributing factor to these infections,” the authors wrote. “To prevent infections, strategies were developed and implemented during the study.”</p><p class="pb-2"></p><p class="pb-2">For patients who experienced neutropenia and/or thrombocytopenia, median recovery times were 13 (95% CI, 12-14) days and 30 (95% CI, 20-46) days, respectively.</p><p class="pb-2"></p><p class="pb-2">Five investigational new drug approval (IND) applications have been approved for eque-cel by the FDA for the therapy’s use in systemic lupus erythematosus and lupus nephritis, multiple sclerosis, and myasthenia gravis.<sup class="text-inherit">7</sup><strong> </strong>It has also received 2 IND approvals from China’s National Medical Products Administration to treat relapsed/refractory multiple myeloma and neuromyelitis optica spectrum disorder.<sup class="text-inherit">8</sup></p><p class="pb-2"></p><p class="pb-2">The authors highlighted the study’s strengths including its representation of the largest Asian population in a CAR T trial and the remarkable response in patients who experienced disease progression on prior BCMA CAR T. Still, limitations were there was no comparator and the total number of patients who had undergone a previous autologous stem cell transplant was low.</p><p class="pb-2"></p><p class="pb-2">“Future studies with a larger and more racially diverse population with long-term follow-up are required,” they concluded.</p><p class="pb-2"></p><p class="pb-2"><strong>References</strong></p><p class="pb-2">1. Li C, Zhou K, Hu Y, et al. Equecabtagene autoleucel in patients with relapsed or refractory multiple myeloma: the FUMANBA-1 nonrandomized clinical trial. <em>JAMA Oncol.</em> Published online November 7, 2024. doi:10.1001/jamaoncol.2024.4879</p><p class="pb-2">2. Lonial S, Lee HC, Badros A, et al. Belantamab mafodotin for relapsed or refractory multiple myeloma (DREAMM-2): a two-arm, randomised, open-label, phase 2 study. <em>Lancet Oncol</em>. 2020;21(2):207-221. doi:10.1016/S1470-2045(19)30788-0</p><p class="pb-2">3. Shaw M. FDA approves cilta-cel for earlier treatment of RRMM. <em>AJMC</em>®. April 6, 2024. Accessed November 6, 2024. <a target="_blank" href="https://www.ajmc.com/view/fda-approves-cilta-cel-for-earlier-treatment-of-rrmm">https://www.ajmc.com/view/fda-approves-cilta-cel-for-earlier-treatment-of-rrmm</a></p><p class="pb-2">4. Bonavitacola J. Ide-cel receives approval for earlier treatment for relapsed, refractory multiple myeloma. <em>AJMC</em>. April 5, 2024. Accessed November 6, 2024. <a target="_blank" href="https://www.ajmc.com/view/ide-cel-receives-approval-for-earlier-treatment-for-relapsed-refractory-multiple-myeloma">https://www.ajmc.com/view/ide-cel-receives-approval-for-earlier-treatment-for-relapsed-refractory-multiple-myeloma</a></p><p class="pb-2">5. <em>AJMC</em> staff. Teclistamab approved for biweekly dosing in R/R multiple myeloma. <em>AJMC</em>. February 23, 2024. Accessed November 6, 2024. <a target="_blank" href="https://www.ajmc.com/view/teclistamab-approved-for-biweekly-dosing-in-r-r-multiple-myeloma">https://www.ajmc.com/view/teclistamab-approved-for-biweekly-dosing-in-r-r-multiple-myeloma</a></p><p class="pb-2">6. Pfizer’s Elrexfio receives U.S. FDA accelerated approval for relapsed or refractory multiple myeloma. News release. Pfizer. August 12, 2024. Accessed November 6, 2024. <a rel="nofollow noreferrer noopener" target="_blank" href="https://investors.pfizer.com/Investors/News/news-details/2023/Pfizers-ELREXFIO-Receives-U.S.-FDA-Accelerated-Approval-for-Relapsed-or-Refractory-Multiple-Myeloma/default.aspx">https://investors.pfizer.com/Investors/News/news-details/2023/Pfizers-ELREXFIO-Receives-U.S.-FDA-Accelerated-Approval-for-Relapsed-or-Refractory-Multiple-Myeloma/default.aspx</a></p><p class="pb-2">7. FDA approves IND application for eque-cel T-cell therapy in SLE, lupus nephritis. News release. Healio. August 12, 2024. Accessed November 6, 2024. <a rel="nofollow noreferrer noopener" target="_blank" href="https://www.healio.com/news/rheumatology/20240812/fda-approves-ind-application-for-equecel-tcell-therapy-in-sle-lupus-nephritis#:~:text=The%20FDA%20has%20cleared%20an,IASO%2C%20said%20in%20the%20release">https://www.healio.com/news/rheumatology/20240812/fda-approves-ind-application-for-equecel-tcell-therapy-in-sle-lupus-nephritis#:~:text=The%20FDA%20has%20cleared%20an,IASO%2C%20said%20in%20the%20release</a></p><p class="pb-2">8. IASO Bio receives U.S. FDA approval of investigational new drug application for equecabtagene autoleucel for two new autoimmune disease indications. News release. PR Newswire. August 12, 2024. Accessed November 6, 2024. <a rel="nofollow noreferrer noopener" target="_blank" href="https://www.prnewswire.com/news-releases/iaso-bio-receives-us-fda-approval-of-investigational-new-drug-application-for-equecabtagene-autoleucel-for-two-new-autoimmune-disease-indications-302219682.html">https://www.prnewswire.com/news-releases/iaso-bio-receives-us-fda-approval-of-investigational-new-drug-application-for-equecabtagene-autoleucel-for-two-new-autoimmune-disease-indications-302219682.html</a></p></div></div><div class="flex items-center lg:w-3/4 mb-4 pb-12"></div><div class="jsx-19ede9f0a5a45918 py-4 relative bg-primary md:px-8 -ml-6 xs:ml-0 w-screen xs:w-auto"><div class="jsx-19ede9f0a5a45918 px-4 sm:px-0"><div class="flex justify-between items-center py-1 space-x-4 border-0 select-none sm:border-b border-secondary"><div class="text-3xl text-white text-lg sm:text-3xl">Related Videos</div></div></div><div style="scroll-snap-type:none" class="jsx-19ede9f0a5a45918 flex items-start 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mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/adults-with-dmd-more-than-twice-as-likely-to-experience-fractures?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/06061deade20b7548bf1379ea5954d86c9277e14-1200x675.jpg?fit=crop&auto=format" alt="Vertebral fractures are common in glucocorticoid-associated osteoporosis and are a clinical indicator of osteoporosis in young patients. | Image credit: Hugnaka - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 14th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/adults-with-dmd-more-than-twice-as-likely-to-experience-fractures?utm_source=www.ajmc.com&utm_medium=relatedContent">Adults With DMD More Than Twice as Likely to Experience Fractures</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/adults-with-dmd-more-than-twice-as-likely-to-experience-fractures?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Less than half of patients had undergone bone monitoring, suggesting a need for better clinical guidance and management of osteoporosis in adult men with Duchenne muscular dystrophy (DMD). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/five-years-later-ongoing-covid-19-challenges-next-steps?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4d74ae04b0508977864936ec08f2aaa199758e5c-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 23rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/five-years-later-ongoing-covid-19-challenges-next-steps?utm_source=www.ajmc.com&utm_medium=relatedContent">Five Years Later: Ongoing COVID-19 Challenges, Next Steps</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/five-years-later-ongoing-covid-19-challenges-next-steps?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we speak with Jenny Han, MD, of Emory School of Medicine and Grady Hospital, about COVID-19, long COVID, and strategies for prevention and care.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/rapid-iv-isatuximab-could-shift-care-practices-in-mm?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/11ee9be36fc4be88ca66a17e7b37ebc45bb91d87-6048x4024.jpg?fit=crop&auto=format" alt="Current practices for IV isatuximab administration takes over an hour | image credit: NAMPIX - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 13th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/rapid-iv-isatuximab-could-shift-care-practices-in-mm?utm_source=www.ajmc.com&utm_medium=relatedContent">Rapid IV Isatuximab Could Shift Care Practices in MM</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/rapid-iv-isatuximab-could-shift-care-practices-in-mm?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Reducing intravenous (IV) isatuximab delivery from 75 minutes to 30 minutes could provide a wealth of benefits to patients with multiple myeloma (MM) and health care systems alike. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/diving-into-patient-preferences-for-blood-cancer-treatments-with-dr-sikander-ailawadhi?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4d74ae04b0508977864936ec08f2aaa199758e5c-1000x563.jpg?fit=crop&auto=format" alt="Diving Into Patient Preferences for Blood Cancer Treatments With Dr Sikander Ailawadhi" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 17th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/diving-into-patient-preferences-for-blood-cancer-treatments-with-dr-sikander-ailawadhi?utm_source=www.ajmc.com&utm_medium=relatedContent">Diving Into Patient Preferences for Blood Cancer Treatments With Dr Sikander Ailawadhi</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/diving-into-patient-preferences-for-blood-cancer-treatments-with-dr-sikander-ailawadhi?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Three abstracts presented at the 2024 American Society of Hematology annual meeting focused on patient preferences and treatment choices in blood cancers.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/understanding-tb-symptoms-spread-treatment-amid-kansas-city-outbreak?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4e67a71e53a44a0736c2c37c0e31fa17cf1c24cc-2876x1537.png?fit=crop&auto=format" alt="Dr Michael Bernstein" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 13th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/understanding-tb-symptoms-spread-treatment-amid-kansas-city-outbreak?utm_source=www.ajmc.com&utm_medium=relatedContent">Understanding TB Symptoms, Spread, Treatment Amid Kansas City Outbreak</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/michael-a-bernstein-md">Michael A. Bernstein, MD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/understanding-tb-symptoms-spread-treatment-amid-kansas-city-outbreak?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In part 2 of this interview, Michael A. Bernstein, MD, highlights the need for prolonged antibiotics and strong public health measures to combat tuberculosis (TB) at both the individual and population levels.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/risdiplam-tablet-for-spinal-muscular-atropy-receives-fda-approval?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/2f366a4ab7421a6a697b539c22b8aedf46713899-6000x4000.jpg?fit=crop&auto=format" alt="FDA approval. | Image Credit: syahrir - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 12th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/risdiplam-tablet-for-spinal-muscular-atropy-receives-fda-approval?utm_source=www.ajmc.com&utm_medium=relatedContent">Risdiplam Tablet for Spinal Muscular Atrophy Receives FDA Approval</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/risdiplam-tablet-for-spinal-muscular-atropy-receives-fda-approval?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The 5 mg risdiplam tablet provides the same efficacy and safety for spinal muscular atrophy as the currently available oral solution.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="relative hidden sm:block"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/adults-with-dmd-more-than-twice-as-likely-to-experience-fractures?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/06061deade20b7548bf1379ea5954d86c9277e14-1200x675.jpg?fit=crop&auto=format" alt="Vertebral fractures are common in glucocorticoid-associated osteoporosis and are a clinical indicator of osteoporosis in young patients. | Image credit: Hugnaka - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 14th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/adults-with-dmd-more-than-twice-as-likely-to-experience-fractures?utm_source=www.ajmc.com&utm_medium=relatedContent">Adults With DMD More Than Twice as Likely to Experience Fractures</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/adults-with-dmd-more-than-twice-as-likely-to-experience-fractures?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Less than half of patients had undergone bone monitoring, suggesting a need for better clinical guidance and management of osteoporosis in adult men with Duchenne muscular dystrophy (DMD). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/five-years-later-ongoing-covid-19-challenges-next-steps?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4d74ae04b0508977864936ec08f2aaa199758e5c-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 23rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/five-years-later-ongoing-covid-19-challenges-next-steps?utm_source=www.ajmc.com&utm_medium=relatedContent">Five Years Later: Ongoing COVID-19 Challenges, Next Steps</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/five-years-later-ongoing-covid-19-challenges-next-steps?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we speak with Jenny Han, MD, of Emory School of Medicine and Grady Hospital, about COVID-19, long COVID, and strategies for prevention and care.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/rapid-iv-isatuximab-could-shift-care-practices-in-mm?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/11ee9be36fc4be88ca66a17e7b37ebc45bb91d87-6048x4024.jpg?fit=crop&auto=format" alt="Current practices for IV isatuximab administration takes over an hour | image credit: NAMPIX - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 13th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/rapid-iv-isatuximab-could-shift-care-practices-in-mm?utm_source=www.ajmc.com&utm_medium=relatedContent">Rapid IV Isatuximab Could Shift Care Practices in MM</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/rapid-iv-isatuximab-could-shift-care-practices-in-mm?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Reducing intravenous (IV) isatuximab delivery from 75 minutes to 30 minutes could provide a wealth of benefits to patients with multiple myeloma (MM) and health care systems alike. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/diving-into-patient-preferences-for-blood-cancer-treatments-with-dr-sikander-ailawadhi?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4d74ae04b0508977864936ec08f2aaa199758e5c-1000x563.jpg?fit=crop&auto=format" alt="Diving Into Patient Preferences for Blood Cancer Treatments With Dr Sikander Ailawadhi" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 17th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/diving-into-patient-preferences-for-blood-cancer-treatments-with-dr-sikander-ailawadhi?utm_source=www.ajmc.com&utm_medium=relatedContent">Diving Into Patient Preferences for Blood Cancer Treatments With Dr Sikander Ailawadhi</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/diving-into-patient-preferences-for-blood-cancer-treatments-with-dr-sikander-ailawadhi?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Three abstracts presented at the 2024 American Society of Hematology annual meeting focused on patient preferences and treatment choices in blood cancers.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/understanding-tb-symptoms-spread-treatment-amid-kansas-city-outbreak?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4e67a71e53a44a0736c2c37c0e31fa17cf1c24cc-2876x1537.png?fit=crop&auto=format" alt="Dr Michael Bernstein" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 13th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/understanding-tb-symptoms-spread-treatment-amid-kansas-city-outbreak?utm_source=www.ajmc.com&utm_medium=relatedContent">Understanding TB Symptoms, Spread, Treatment Amid Kansas City Outbreak</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/michael-a-bernstein-md">Michael A. Bernstein, MD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/understanding-tb-symptoms-spread-treatment-amid-kansas-city-outbreak?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In part 2 of this interview, Michael A. Bernstein, MD, highlights the need for prolonged antibiotics and strong public health measures to combat tuberculosis (TB) at both the individual and population levels.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/risdiplam-tablet-for-spinal-muscular-atropy-receives-fda-approval?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/2f366a4ab7421a6a697b539c22b8aedf46713899-6000x4000.jpg?fit=crop&auto=format" alt="FDA approval. | Image Credit: syahrir - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 12th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/risdiplam-tablet-for-spinal-muscular-atropy-receives-fda-approval?utm_source=www.ajmc.com&utm_medium=relatedContent">Risdiplam Tablet for Spinal Muscular Atrophy Receives FDA Approval</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/risdiplam-tablet-for-spinal-muscular-atropy-receives-fda-approval?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The 5 mg risdiplam tablet provides the same efficacy and safety for spinal muscular atrophy as the currently available oral solution.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="pb-24"></div></div><script type="application/ld+json">{"@context":"https://schema.org","@type":"NewsArticle","headline":"Eque-Cel CAR T Shows Strong Results for Multiple Myeloma","datePublished":"2024-11-07T16:00:00.000Z","dateModified":"2024-11-18T19:22:24Z","inLanguage":"en-US","image":"https://cdn.sanity.io/images/0vv8moc6/ajmc/d6cda65715e52774e2cab34d922cdd302167b243-1200x738.jpg?fit=crop&auto=format","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.ajmc.com/view/eque-cel-car-t-shows-strong-results-for-multiple-myeloma"},"publisher":{"@type":"Organization","name":"AJMC","logo":{"@type":"ImageObject","url":"https://www.ajmc.com/ajmc_logo_inverted.png"}},"keywords":"multiple myeloma,Eque-cel,Equecabtagene autoleucel ","articleBody":"Equecabtagene autoleucel (eque-cel), an investigative fully human-derived B-cell maturation antigen (BCMA)–targeting chimeric antigen receptor (CAR) T-cell therapy directed against multiple myeloma, has shown great promise in a new study conducted at 14 centers in China, with both CAR T–naive (88.3%) and CAR T–experienced (11.7%) patients showing benefit.\n\n\n\nEarly, deep, and durable responses were seen among 103 patients who received a single treatment infusion at 1.0 x 106 CAR-positive T cells/kg after lymphodepletion, as participants (N = 103) in the phase 1b/2 nonrandomized FUMANBA-1 trial (ChiCTR2000033946), according to results published online today in JAMA Oncology.1 All of the patients had received at least 3 prior lines of therapy, but not everyone had received prior CAR T. The primary outcome of interest of this analysis was efficacy, via overall response rate (ORR), and secondary outcomes of interest were safety, pharmacokinetics, and pharmacodynamics. Minimal residual disease (MRD) status was assessed at screening, baseline, and when patients achieved at least a very good partial response (PR) or disease progression. Study participants will be followed for at least 15 years for ongoing response monitoring.\n\n\n\nOther BCMA-directed therapies have proved effective against multiple myeloma, backed by results from several prominent trials: DREAMM-2 (NCT03525678),2 Cartitude-4,3 KarMMa-3,4 MajesTEC-1,5 and MagnetisMM-3.6 However, more data are needed on human use of fully human-derived BCMA CAR T therapies such as eque-cel.\n\n\n\nPrior to receiving eque-cel, the patients underwent lymphodepletion with 500 mg/m2 of cyclophosphamide and 30 mg/m2 of fludarabine administered intravenously daily for 3 consecutive days. Most (53.4%) were male patients, and their median age was 58 (range, 39-70) years. All were Chinese. Among those who received bridging therapy (46.6%), 3 achieved a PR; 9 had a minor response; 22 had stable disease; and 14 experienced disease progression.\n\n\n\nThe median follow-up was 13.8 (range, 0.4-27.2) months, and during this time, the ORR was 96%, and it was 99% among those naive to CAR T. Median time to first response of at least a PR was 16 (range, 11-179) days, and to best response, 92 (range, 14-557) days. At 3 months after CAR T infusion, the ORR remained high, at 94.1%, and 42.6% had achieved a complete response (CR) or a stringent CR (sCR). By the 12-month mark, the latter measure had jumped to 73.3%. Among the patients with no history of CAR T, the CR/sCR rate was 79%.\n\n\n\n\n\nThere was also a very high MRD negativity rate of 95%, with a median time to this outcome of 15 (range, 14-186) days, with 8 patients sustaining this status for over 2 years. Also among those who achieved MRD negativity, the CR rate was 75% and the sCR rate was 42%.\n\n\n\nMedian progression-free survival and overall survival were not reached, but at 12 months, these measures were 78.8% (95% CI, 68.6%-86.0%) and 92.2% (95% CI, 84.3%-96.2%). Further, in CAR T-cell therapy–naive patients, the ORR and PFS were superior compared with CAR T–experienced patients.\n\n\n\nFollowing the infusion, the median maximum copy number was 87,571 (range, 439-196,888 copies/μg DNA), and median time to maximum copy number was 12 (range, 0-23) days.\n\n\n\nOf the total patient cohort, 102 experienced adverse events (AEs), 94.2% of which were grade 3 or higher, and these included neutropenia (81.6%), leukopenia (74.8%), thrombocytopenia (59.2%), lymphopenia (59.2%), and anemia (51.5%). Cytokine release syndrome was also a common AE (grade 1/2, 92.2%; grade 4, 1%), at a median (IQR) duration of 5 (4-7) days and a median time to onset of 6 (4-7.5) days. Infection treatment-related serious AEs were seen in 32 patients, and 14 patients died.\n\n\n\n“The impaired humoral immunity, characterized by prolonged B-cell depletion and hypogammaglobulinemia, was a significant contributing factor to these infections,” the authors wrote. “To prevent infections, strategies were developed and implemented during the study.”\n\n\n\nFor patients who experienced neutropenia and/or thrombocytopenia, median recovery times were 13 (95% CI, 12-14) days and 30 (95% CI, 20-46) days, respectively.\n\n\n\nFive investigational new drug approval (IND) applications have been approved for eque-cel by the FDA for the therapy’s use in systemic lupus erythematosus and lupus nephritis, multiple sclerosis, and myasthenia gravis.7 It has also received 2 IND approvals from China’s National Medical Products Administration to treat relapsed/refractory multiple myeloma and neuromyelitis optica spectrum disorder.8\n\n\n\nThe authors highlighted the study’s strengths including its representation of the largest Asian population in a CAR T trial and the remarkable response in patients who experienced disease progression on prior BCMA CAR T. Still, limitations were there was no comparator and the total number of patients who had undergone a previous autologous stem cell transplant was low.\n\n\n\n“Future studies with a larger and more racially diverse population with long-term follow-up are required,” they concluded.\n\n\n\nReferences\n\n1. Li C, Zhou K, Hu Y, et al. Equecabtagene autoleucel in patients with relapsed or refractory multiple myeloma: the FUMANBA-1 nonrandomized clinical trial. JAMA Oncol. Published online November 7, 2024. doi:10.1001/jamaoncol.2024.4879\n\n2. Lonial S, Lee HC, Badros A, et al. Belantamab mafodotin for relapsed or refractory multiple myeloma (DREAMM-2): a two-arm, randomised, open-label, phase 2 study. Lancet Oncol. 2020;21(2):207-221. doi:10.1016/S1470-2045(19)30788-0\n\n3. Shaw M. FDA approves cilta-cel for earlier treatment of RRMM. AJMC®. April 6, 2024. Accessed November 6, 2024. https://www.ajmc.com/view/fda-approves-cilta-cel-for-earlier-treatment-of-rrmm\n\n4. Bonavitacola J. Ide-cel receives approval for earlier treatment for relapsed, refractory multiple myeloma. AJMC. April 5, 2024. Accessed November 6, 2024. https://www.ajmc.com/view/ide-cel-receives-approval-for-earlier-treatment-for-relapsed-refractory-multiple-myeloma\n\n5. AJMC staff. Teclistamab approved for biweekly dosing in R/R multiple myeloma. AJMC. February 23, 2024. Accessed November 6, 2024. https://www.ajmc.com/view/teclistamab-approved-for-biweekly-dosing-in-r-r-multiple-myeloma\n\n6. Pfizer’s Elrexfio receives U.S. FDA accelerated approval for relapsed or refractory multiple myeloma. News release. Pfizer. August 12, 2024. Accessed November 6, 2024. https://investors.pfizer.com/Investors/News/news-details/2023/Pfizers-ELREXFIO-Receives-U.S.-FDA-Accelerated-Approval-for-Relapsed-or-Refractory-Multiple-Myeloma/default.aspx\n\n7. FDA approves IND application for eque-cel T-cell therapy in SLE, lupus nephritis. News release. Healio. August 12, 2024. Accessed November 6, 2024. https://www.healio.com/news/rheumatology/20240812/fda-approves-ind-application-for-equecel-tcell-therapy-in-sle-lupus-nephritis#:~:text=The%20FDA%20has%20cleared%20an,IASO%2C%20said%20in%20the%20release\n\n8. IASO Bio receives U.S. FDA approval of investigational new drug application for equecabtagene autoleucel for two new autoimmune disease indications. News release. PR Newswire. August 12, 2024. Accessed November 6, 2024. https://www.prnewswire.com/news-releases/iaso-bio-receives-us-fda-approval-of-investigational-new-drug-application-for-equecabtagene-autoleucel-for-two-new-autoimmune-disease-indications-302219682.html","description":"Multiple myeloma is the second most common hematologic malignancy, but there is a treatment gap for patients with disease progression following standard-of-care therapies that include immunomodulatory agents, proteasome inhibitors, and anti-CD38 antibodies.","author":[{"@type":"Person","name":"Maggie L. Shaw"}]}</script></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><div id="footerOuterWrap" class=" mx-auto flex"><div class="bg-[#00598D] xl:w-[70%] w-[70%] py-12 pl-auto"><div class="xxl:w-[75%] w-[90%] ml-auto"><div><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span 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The primary outcome of interest of this analysis was efficacy, via overall response rate (ORR), and secondary outcomes of interest were safety, pharmacokinetics, and pharmacodynamics. Minimal residual disease (MRD) status was assessed at screening, baseline, and when patients achieved at least a very good partial response (PR) or disease progression. 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Most (53.4%) were male patients, and their median age was 58 (range, 39-70) years. All were Chinese. Among those who received bridging therapy (46.6%), 3 achieved a PR; 9 had a minor response; 22 had stable disease; and 14 experienced disease progression.","_key":"4f67f995388c4","_type":"span"}],"_type":"block"},{"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"_key":"85c92b6666c90","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"dfd084a90c10","upload_doc":null},{"_key":"c410c9acafc8","upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The median follow-up was 13.8 (range, 0.4-27.2) months, and during this time, the ORR was 96%, and it was 99% among those naive to CAR T. Median time to first response of at least a PR was 16 (range, 11-179) days, and to best response, 92 (range, 14-557) days. At 3 months after CAR T infusion, the ORR remained high, at 94.1%, and 42.6% had achieved a complete response (CR) or a stringent CR (sCR). By the 12-month mark, the latter measure had jumped to 73.3%. 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The study highlights the need for improved clinical guidelines for osteoporosis management in this population. The research underscores the importance of regular lateral spine imaging to detect vertebral fractures, as relying solely on symptoms may underestimate their frequency in this high-risk group.","factCheckAuthorMapping":null,"factCheckAuthors":null,"_id":"e8553f02-8c8e-474a-aff1-3fc1c824a93a","body":[{"markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://onlinelibrary.wiley.com/doi/10.1002/mus.28355","_key":"05b7bf38cc4d"},{"href":"https://www.ajmc.com/compendium/dmd","_key":"542e20093b6c","nofollow":false,"blank":true,"_type":"link"}],"children":[{"_type":"span","marks":[],"text":"Adult men with ","_key":"8acd9ee4b20b"},{"_type":"span","marks":["542e20093b6c"],"text":"Duchenne muscular dystrophy ","_key":"81792332f52b"},{"_key":"653185e9eb66","_type":"span","marks":[],"text":"(DMD) were more than twice as likely to experience fractures compared with adult men without DMD in the UK, a recent study published in "},{"_type":"span","marks":["em","05b7bf38cc4d"],"text":"Muscle \u0026 Nerve","_key":"6d650ca71ef6"},{"_type":"span","marks":[],"text":" found.","_key":"676cd35332d4"},{"marks":["sup"],"text":"1","_key":"5e4cb1df636f","_type":"span"},{"_type":"span","marks":[],"text":" However, less than half of the patient population had undergone bone monitoring, which suggests a need for better clinical guidance and management of osteoporosis in adult men with DMD.","_key":"42e6ceece903"}],"_type":"block","style":"normal","_key":"7f14a441fa4c"},{"alignment":"right","imgcaption":[{"children":[{"_type":"span","marks":[],"text":"Vertebral fractures are common in glucocorticoid-associated osteoporosis and are a clinical indicator of osteoporosis in young patients. | Image credit: Hugnaka - stock.adobe.com","_key":"7403c6dfd770"}],"_type":"block","style":"normal","_key":"694ab3f0eb46","markDefs":[]}],"alt":"Vertebral fractures are common in glucocorticoid-associated osteoporosis and are a clinical indicator of osteoporosis in young patients. | Image credit: Hugnaka - stock.adobe.com","asset":{"_ref":"image-06061deade20b7548bf1379ea5954d86c9277e14-1200x675-jpg","_type":"reference"},"widthP":35,"disableLightBox":true,"_type":"figure","disableTextWrap":false,"_key":"e1efbc2c6364"},{"style":"normal","_key":"419a8ce0f25d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Past research has shown that children and adolescents with DMD are at a significantly increased risk of low-trauma fractures.","_key":"aafda75582aa"},{"marks":["sup"],"text":"2","_key":"f1fcba87b350","_type":"span"},{"_type":"span","marks":[],"text":" The use of corticosteroids, which are standard in DMD care and have improved survival and other key outcomes in patients with DMD, is also associated with osteoporosis leading to low-trauma fractures.","_key":"a6cc8627040f"},{"_key":"3ad37948d0bd","_type":"span","marks":["sup"],"text":"3"},{"_type":"span","marks":[],"text":" But data on fractures in adults with DMD are limited, the study authors explained.","_key":"78ffbbcca916"},{"_type":"span","marks":["sup"],"text":"1","_key":"e1ed680a05d7"}],"_type":"block"},{"_key":"3ade6a6b8dfe","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"af265de9c22d"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"b62950412261","_type":"span","marks":[],"text":"“Information on fractures in adults with DMD is scarce and not well-studied,” the authors wrote. “With the increased utilization of corticosteroids, and advancements in coordinated multi-disciplinary care, there is a growing population of adults with DMD, warranting a focus on extra-skeletal health outcomes in addition to skeletal outcomes.”"}],"_type":"block","style":"normal","_key":"d1835c5073f7"},{"markDefs":[],"children":[{"_key":"128768c8b4e5","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"3e24e881ce5e"},{"_key":"7139d098d200","markDefs":[],"children":[{"_key":"ad1763b21852","_type":"span","marks":[],"text":"The study authors conducted a retrospective 10-year review including all adults 16 years and older with DMD who were receiving care from neurology or respiratory physicians between January 2013 and December 2022 in Scotland. A total of 36 men with DMD were included in the analysis."}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"82dd36655f47","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"72cdc6c845ab"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Overall, 5 patients (14%) experienced fractures during the study period, and 7 total fractures were reported. Three of these patients were being treated with corticosteroids when fractures occurred. All fractures except 1 were considered low-trauma fractures. All except 1 of the patients who experienced fractures were nonambulant at the time, and the patient who was ambulant at the time of the fracture subsequently lost ambulation.","_key":"9b69a91c0b89"}],"_type":"block","style":"normal","_key":"84d25bdb4706"},{"style":"normal","_key":"8a19c5ce406c","markDefs":[],"children":[{"text":"","_key":"041968207a6d","_type":"span","marks":[]}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The incidence of fracture among the DMD cohort was 295.4 per 10,000 person-years (95% CI, 118.7-608.6)—more than double the rate among men in the UK aged 18 to 49 years (94.8 per 10,000 person-years). There was a higher rate of fracture in patients with DMD taking corticosteroids (888.9 per 10,000 person-years [95% CI, 242.2-2275.9]) vs those not on corticosteroids (156.3 per 10,000 person-years [95% CI, 32.2-456.6]). The authors also noted that fractures in healthy young men are typically due to significant trauma, whereas all but 1 fracture in the DMD cohort were low-trauma fractures.","_key":"b8e2c99df6d5"}],"_type":"block","style":"normal","_key":"25a1f373e1fd"},{"children":[{"_key":"90fd17917bb9","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"b82edc785983","markDefs":[]},{"_key":"35c1f89999da","markDefs":[],"children":[{"_type":"span","marks":[],"text":"No new vertebral fractures were recorded during follow-up, but the authors noted that lateral spine imaging to assess for vertebral fractures was not part of routine clinical monitoring. Only 18 patients (50%) had lateral spine imaging to check for vertebral fractures at least once during the follow-up period, and just 5 (14%) had lateral spine radiographs within 2 years of their last visit. Fifteen patients (42%) underwent a dual energy X-ray absorptiometry (DXA) scan to assess bone density at least once during follow-up, and 5 (14%) had DXA scans within 2 years of their last visit. 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The treatment has shown great benefits for this subset of patients with MM. When isatuximab was added to the standard-of-care regimen, as demonstrated by the IMROZ (NCT03319667) trial, patients exhibited a 40% risk reduction for disease progression or death (HR, 0.60; 95% CI, 0.44-0.81; ","_key":"38304689c1d8"},{"_type":"span","marks":["em"],"text":"P","_key":"1ed195a6d415"},{"_type":"span","marks":[],"text":" = .0009).","_key":"38ad002a2121"},{"_type":"span","marks":["sup"],"text":"2","_key":"d7d76db377b6"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"d44cb2700356"}],"_type":"block","style":"normal","_key":"c2a577406699","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"At present, IV administration requires a minimum of 75 minutes to complete. 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What makes certain communities more vulnerable to outbreaks?","_key":"f5ce6d120710"}],"_type":"block","style":"normal"},{"style":"normal","_key":"a6b5a5565a89","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"10992e70381e"}],"_type":"block"},{"_type":"block","style":"normal","_key":"059388e4c48b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"TB really is a disease that, internationally, upwards of two-thirds of the world will either have been infected and cleared of TB, or have certainly been highly exposed to TB during their life. In countries like the US, we don't face TB as strongly as most of the rest of the world does. The communities that have been at the biggest risk for TB in the US for years are immigrant or recent immigrant communities, and particularly over the last 30 years or 40 years, HIV or HIV-positive patients. There's a number of medications that we use for a whole series of different diseases, usually autoimmune diseases, that can put patients at risk for TB. Those are the 3 communities I sort of think about for who we need to focus in on our TB risks. ","_key":"d03cd42b3196"}]},{"_key":"5ba98fbd1e5e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"TB had dramatically decreasing rates in the US up through the late 1980s and early 1990s when the HIV epidemic really changed the face of TB for concurrent infections. There's been tremendous public health advances, obviously, with HIV over the last 30 years. That population has sort of seen a steady decline, but, over the last 5 years, there's been a re-increase in the number of patients with TB across the US.","_key":"81b78dfcb739"}],"_type":"block","style":"normal"},{"children":[{"text":"","_key":"e0dba53462c6","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"c00580122d07","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"What are the early symptoms of TB? How can people differentiate them from other respiratory illnesses?","_key":"60f53436b906"}],"_type":"block","style":"normal","_key":"319434f5aa6e"},{"style":"normal","_key":"f896940fbbab","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"183121010fcf"}],"_type":"block"},{"style":"normal","_key":"50b201580803","markDefs":[],"children":[{"_type":"span","marks":[],"text":"So, TB is a more chronic and slow disease. The old, again using the term \"romantic,\" name for TB, was consumption, meaning that it would sort of eat at you. So, weight loss was a very common early symptom. The big ones are weight loss, cough, fevers, and coughing up blood, in particular, which we call hemoptysis; those are the main ones for pulmonary TB. ","_key":"bd0f8425fe0e"}],"_type":"block"},{"_type":"block","style":"normal","_key":"d3c671afa46b","markDefs":[],"children":[{"text":"TB can occur in other parts of the body besides the lungs, and those present with a myriad of different complaints, but, for the most part, the biggest impact is in the respiratory system, and those of cough, fever, and coughing up blood would be the biggest.","_key":"54298d3f8992","_type":"span","marks":[]}]},{"style":"normal","_key":"b8f578c1a8f8","markDefs":[],"children":[{"text":"","_key":"adf908f66f8b","_type":"span","marks":[]}],"_type":"block"},{"_type":"block","style":"normal","_key":"ab7ff127648b","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"What are the current treatment options for TB?","_key":"7716e02b3d11"}]},{"_type":"block","style":"normal","_key":"e12abbc02a87","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f0a970b81909"}]},{"_key":"818d9c68901d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The mainstay of treatment for TB is a series of different antibiotics. Some of the antibiotics are used for other bacterial infections, and some of the antibiotics are limited only to the use of TB, but it's not as easy as 1 antibiotic. The most common treatment regimen for TB is 4 antibiotics, and patients are treated for upwards of 6 months, which is much longer than you would think for strep throat or an ear infection. ","_key":"00a0c70aae57"}],"_type":"block","style":"normal"},{"_key":"201628c3b3bc","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f4496620ea7a"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"text":"It's also very important that TB can become resistant to antibiotics. So, when patients are put on antibiotics, they need to be observed and treated in a conservative and appropriate way to make sure that they're not just starting the treatment and stopping, because that puts the entire community at risk if you develop strands of TB that are resistant to the antibiotics we currently have. 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Unlike the liquid formulation, the tablet can be stored at room temperature.","_key":"07b3cb9d336f"}],"_type":"block"},{"_type":"block","style":"normal","_key":"3929d13076f6","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"801b815e4f03"}]},{"_key":"dc940fba2793","markDefs":[{"href":"https://www.ajmc.com/view/fda-approves-at-home-oral-treatment-for-spinal-muscular-atrophy","_key":"504940ffc772","blank":true,"_type":"link"}],"children":[{"_key":"9f35e8d10728","_type":"span","marks":[],"text":"Risdiplam received its original "},{"_type":"span","marks":["504940ffc772"],"text":"approval","_key":"d1d3b701a853"},{"text":" in 2020, making it the first therapy approved for at-home oral administration in patients with SMA.","_key":"6a0e78930488","_type":"span","marks":[]},{"_type":"span","marks":["sup"],"text":"2","_key":"9fb9afc19239"},{"_key":"7fb286786188","_type":"span","marks":[],"text":" That approval was based on findings from a pair of clinical trials: FIREFISH (NCT02913482) and SUNFISH (NCT02908685)."}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"0ced5b93f3d0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"c36736645d1d"},{"markDefs":[],"children":[{"marks":[],"text":"In the FIREFISH study, 90% of infants treated were alive without permanent ventilation at 12 months of treatment and reached 15 months of age or older, and 41% of infants achieved the ability to sit without support for at least 5 seconds. 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