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Galactoside acetyltransferase - Wikipedia

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src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d7/GattrimerB_IPTG.jpg/310px-GattrimerB_IPTG.jpg" decoding="async" width="310" height="231" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d7/GattrimerB_IPTG.jpg/465px-GattrimerB_IPTG.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d7/GattrimerB_IPTG.jpg/620px-GattrimerB_IPTG.jpg 2x" data-file-width="1008" data-file-height="752" /></a><figcaption>GAT in complex with CoA and two molecules/active site of IPTG viewed perpendicular to the molecular threefold axis of the enzyme</figcaption></figure> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Galactoside O-acetyltransferase</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC no.</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.enzyme-database.org/query.php?ec=2.3.1.18">2.3.1.18</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/CAS_registry_number" class="mw-redirect" title="CAS registry number">CAS no.</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=9029-94-1&amp;title=">9029-94-1 </a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Databases</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/IntEnz" title="IntEnz">IntEnz</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/intenz/query?cmd=SearchEC&amp;ec=2.3.1.18">IntEnz view</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/BRENDA" title="BRENDA">BRENDA</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.brenda-enzymes.org/enzyme.php?ecno=2.3.1.18">BRENDA entry</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/ExPASy" class="mw-redirect" title="ExPASy">ExPASy</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/2.3.1.18">NiceZyme view</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genome.jp/dbget-bin/www_bget?enzyme+2.3.1.18">KEGG entry</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/MetaCyc" title="MetaCyc">MetaCyc</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://biocyc.org/META/substring-search?type=NIL&amp;object=2.3.1.18">metabolic pathway</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/PRIAM_enzyme-specific_profiles" title="PRIAM enzyme-specific profiles">PRIAM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://priam.prabi.fr/cgi-bin/PRIAM_profiles_CurrentRelease.pl?EC=2.3.1.18">profile</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> structures</th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity.rcsb_ec_lineage.id:2.3.1.18">RCSB PDB</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?ec_number:2.3.1.18">PDBe</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes/GetPage.pl?ec_number=2.3.1.18">PDBsum</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Gene_Ontology" title="Gene Ontology">Gene Ontology</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008870">AmiGO </a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/term/GO:0008870">QuickGO</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;term=2.3.1.18%5BEC/RN%20Number%5D%20AND%20pubmed%20pmc%20local%5Bsb%5D">articles</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PubMed" title="PubMed">PubMed</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;term=2.3.1.18%5BEC/RN%20Number%5D">articles</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">NCBI</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein?term=2.3.1.18%5BEC/RN%20Number%5D">proteins</a></td></tr></tbody></table></td></tr></tbody></table> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above" style="font-size: 125%">Thiogalactoside acetyltransferase</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Organism</th><td class="infobox-data" style="background-color: #eee"><span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=511145&amp;rn=1"><i>Escherichia coli</i></a></span></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">lacA</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&amp;dopt=default&amp;rn=1&amp;list_uids=945674">945674</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">RefSeq (Prot)</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NP_414876">NP_414876</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P07464">P07464</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search for</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Structures</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://swissmodel.expasy.org/repository/uniprot/P07464">Swiss-model</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Domains</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/protein/P07464">InterPro</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Galactoside acetyltransferase</b> (also known as <b>Galactoside O-acetyltransferase</b>, <b>thiogalactoside transacetylase</b>, <b>β-galactoside transacetylase</b> and <b>GAT</b>) is an <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> that transfers an <a href="/wiki/Acetyl_group" title="Acetyl group">acetyl group</a> from <a href="/wiki/Acetyl-CoA" title="Acetyl-CoA">acetyl-CoA</a> to <a href="/wiki/%CE%92-galactoside" class="mw-redirect" title="Β-galactoside">β-galactosides</a>, <a href="/wiki/Glucoside" title="Glucoside">glucosides</a> and lactosides. It is coded for by the <i>lacA</i> gene of the <a href="/wiki/Lac_operon" title="Lac operon"><i>lac</i> operon</a> in <i><a href="/wiki/E._coli" class="mw-redirect" title="E. coli">E. coli</a></i>.<sup id="cite_ref-:0_1-0" class="reference"><a href="#cite_note-:0-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Reaction">Reaction</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Galactoside_acetyltransferase&amp;action=edit&amp;section=1" title="Edit section: Reaction"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>It catalyzes the following reaction: </p><p><a href="/wiki/Acetyl-CoA" title="Acetyl-CoA">acetyl-CoA</a> + <a href="/wiki/Galactoside" title="Galactoside">beta-D-galactoside</a> → <a href="/wiki/Coenzyme_A" title="Coenzyme A">CoA</a> + 6-acetyl-beta-D-galactoside </p><p>The kinetics of the enzyme were delineated in 1995.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">&#91;</span>2<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Biological_role">Biological role</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Galactoside_acetyltransferase&amp;action=edit&amp;section=2" title="Edit section: Biological role"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The enzyme's role in the classical <i>E.coli</i> <i>lac</i> operon remains unclear.<sup id="cite_ref-:0_1-1" class="reference"><a href="#cite_note-:0-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">&#91;</span>3<span class="cite-bracket">&#93;</span></a></sup> However, the enzyme's cellular role may be to detoxify non-metabolizable pyranosides by acetylating them and preventing their reentry into the cell.<sup id="cite_ref-:0_1-2" class="reference"><a href="#cite_note-:0-1"><span class="cite-bracket">&#91;</span>1<span class="cite-bracket">&#93;</span></a></sup><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">&#91;</span>4<span class="cite-bracket">&#93;</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Galactoside_acetyltransferase&amp;action=edit&amp;section=3" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Transacetylase" class="mw-redirect" title="Transacetylase">Transacetylase</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Galactoside_acetyltransferase&amp;action=edit&amp;section=4" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-:0-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-:0_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:0_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:0_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"> <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFWangOlsenRoderick2002" class="citation journal cs1">Wang XG, Olsen LR, Roderick SL (April 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0969-2126%2802%2900741-4">"Structure of the lac operon galactoside acetyltransferase"</a>. <i>Structure</i>. <b>10</b> (4): 581–8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0969-2126%2802%2900741-4">10.1016/S0969-2126(02)00741-4</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11937062">11937062</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Structure&amp;rft.atitle=Structure+of+the+lac+operon+galactoside+acetyltransferase&amp;rft.volume=10&amp;rft.issue=4&amp;rft.pages=581-8&amp;rft.date=2002-04&amp;rft_id=info%3Adoi%2F10.1016%2FS0969-2126%2802%2900741-4&amp;rft_id=info%3Apmid%2F11937062&amp;rft.aulast=Wang&amp;rft.aufirst=XG&amp;rft.au=Olsen%2C+LR&amp;rft.au=Roderick%2C+SL&amp;rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0969-2126%252802%252900741-4&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AGalactoside+acetyltransferase" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLewendonEllisShaw1995" class="citation journal cs1">Lewendon A, Ellis J, Shaw WV (November 1995). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.270.44.26326">"Structural and mechanistic studies of galactoside acetyltransferase, the <i>Escherichia coli</i> LacA gene product"</a>. <i>The Journal of Biological Chemistry</i>. <b>270</b> (44): 26326–31. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.270.44.26326">10.1074/jbc.270.44.26326</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7592843">7592843</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=The+Journal+of+Biological+Chemistry&amp;rft.atitle=Structural+and+mechanistic+studies+of+galactoside+acetyltransferase%2C+the+Escherichia+coli+LacA+gene+product&amp;rft.volume=270&amp;rft.issue=44&amp;rft.pages=26326-31&amp;rft.date=1995-11&amp;rft_id=info%3Adoi%2F10.1074%2Fjbc.270.44.26326&amp;rft_id=info%3Apmid%2F7592843&amp;rft.aulast=Lewendon&amp;rft.aufirst=A&amp;rft.au=Ellis%2C+J&amp;rft.au=Shaw%2C+WV&amp;rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.270.44.26326&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AGalactoside+acetyltransferase" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRoderick2005" class="citation journal cs1">Roderick SL (June 2005). <a rel="nofollow" class="external text" href="https://comptes-rendus.academie-sciences.fr/biologies/articles/10.1016/j.crvi.2005.03.005/">"The lac operon galactoside acetyltransferase"</a>. <i>Comptes Rendus Biologies</i>. <b>328</b> (6): 568–75. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.crvi.2005.03.005">10.1016/j.crvi.2005.03.005</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a>&#160;<a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15950163">15950163</a>.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.jtitle=Comptes+Rendus+Biologies&amp;rft.atitle=The+lac+operon+galactoside+acetyltransferase&amp;rft.volume=328&amp;rft.issue=6&amp;rft.pages=568-75&amp;rft.date=2005-06&amp;rft_id=info%3Adoi%2F10.1016%2Fj.crvi.2005.03.005&amp;rft_id=info%3Apmid%2F15950163&amp;rft.aulast=Roderick&amp;rft.aufirst=SL&amp;rft_id=https%3A%2F%2Fcomptes-rendus.academie-sciences.fr%2Fbiologies%2Farticles%2F10.1016%2Fj.crvi.2005.03.005%2F&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AGalactoside+acetyltransferase" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation journal cs1"><a rel="nofollow" class="external text" href="http://jb.asm.org/content/128/1/510.abstract">"Thiogalactoside transacetylase of the lactose operon as an enzyme for detoxification"</a>. 1976.</cite><span title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.atitle=Thiogalactoside+transacetylase+of+the+lactose+operon+as+an+enzyme+for+detoxification.&amp;rft.date=1976&amp;rft_id=http%3A%2F%2Fjb.asm.org%2Fcontent%2F128%2F1%2F510.abstract&amp;rfr_id=info%3Asid%2Fen.wikipedia.org%3AGalactoside+acetyltransferase" class="Z3988"></span> <span class="cs1-visible-error citation-comment"><code class="cs1-code">{{<a href="/wiki/Template:Cite_journal" title="Template:Cite journal">cite journal</a>}}</code>: </span><span class="cs1-visible-error citation-comment">Cite journal requires <code class="cs1-code">&#124;journal=</code> (<a href="/wiki/Help:CS1_errors#missing_periodical" title="Help:CS1 errors">help</a>)</span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span 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acetyltransferase</a> at Wikimedia Commons</li> <li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=galactoside+acetyltransferase">galactoside+acetyltransferase</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> <a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/2.3.1.18">2.3.1.18</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline 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.navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Acyltransferases" title="Template:Acyltransferases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Acyltransferases" title="Template talk:Acyltransferases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Acyltransferases" title="Special:EditPage/Template:Acyltransferases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Transferases:_acyltransferases_(EC_2.3)" style="font-size:114%;margin:0 4em"><a href="/wiki/Transferase" title="Transferase">Transferases</a>: <a href="/wiki/Acyltransferase" title="Acyltransferase">acyltransferases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 2.3)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_2)#EC_2.3.1:_Transferring_groups_other_than_amino-acyl_groups" title="List of EC numbers (EC 2)">2.3.1</a>: other than amino-acyl groups</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Acetyltransferase" title="Acetyltransferase">acetyltransferases</a>:</i> <a href="/wiki/Thiolase" title="Thiolase">Acetyl-Coenzyme A acetyltransferase</a></li> <li><a href="/wiki/N-Acetylglutamate_synthase" title="N-Acetylglutamate synthase">N-Acetylglutamate synthase</a></li> <li><a href="/wiki/Choline_acetyltransferase" title="Choline acetyltransferase">Choline acetyltransferase</a></li> <li><a href="/wiki/Dihydrolipoyl_transacetylase" title="Dihydrolipoyl transacetylase">Dihydrolipoyl transacetylase</a></li> <li><a href="/wiki/Acetyl-CoA_C-acyltransferase" class="mw-redirect" title="Acetyl-CoA C-acyltransferase">Acetyl-CoA C-acyltransferase</a></li> <li><a href="/wiki/Beta-galactoside_transacetylase" class="mw-redirect" title="Beta-galactoside transacetylase">Beta-galactoside transacetylase</a></li> <li><a href="/wiki/Chloramphenicol_acetyltransferase" title="Chloramphenicol acetyltransferase">Chloramphenicol acetyltransferase</a></li> <li><a href="/wiki/N-acetyltransferase" title="N-acetyltransferase">N-acetyltransferase</a> <ul><li><a href="/wiki/Serotonin_N-acetyl_transferase" class="mw-redirect" title="Serotonin N-acetyl transferase">Serotonin N-acetyl transferase</a></li> <li><a href="/wiki/HGSNAT" title="HGSNAT">HGSNAT</a></li> <li><a href="/wiki/ARD1A" class="mw-redirect" title="ARD1A">ARD1A</a></li></ul></li> <li><a href="/wiki/Histone_acetyltransferase" title="Histone acetyltransferase">Histone acetyltransferase</a> <ul><li><a href="/wiki/P300-CBP_coactivator_family" title="P300-CBP coactivator family">P300/CBP</a></li> <li><a href="/wiki/NAT2" class="mw-redirect" title="NAT2">NAT2</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Palmitoyltransferase" class="mw-redirect" title="Palmitoyltransferase">palmitoyltransferases</a>:</i> <a href="/wiki/Carnitine_O-palmitoyltransferase" title="Carnitine O-palmitoyltransferase">Carnitine O-palmitoyltransferase</a> <ul><li><a href="/wiki/Carnitine_palmitoyltransferase_I" title="Carnitine palmitoyltransferase I">CPT1</a></li> <li><a href="/wiki/Carnitine_palmitoyltransferase_II" title="Carnitine palmitoyltransferase II">CPT2</a></li></ul></li> <li><a href="/wiki/Serine_C-palmitoyltransferase" title="Serine C-palmitoyltransferase">Serine C-palmitoyltransferase</a> <ul><li><a href="/wiki/SPTLC1" title="SPTLC1">SPTLC1</a></li> <li><a href="/wiki/SPTLC2" title="SPTLC2">SPTLC2</a></li></ul></li></ul> <ul><li><i>other:</i> <a href="/wiki/Acyltransferase_like_2" title="Acyltransferase like 2">Acyltransferase like 2</a></li> <li><a href="/wiki/Aminolevulinic_acid_synthase" title="Aminolevulinic acid synthase">Aminolevulinic acid synthase</a></li> <li><a href="/wiki/Beta-ketoacyl-ACP_synthase" title="Beta-ketoacyl-ACP synthase">Beta-ketoacyl-ACP synthase</a></li> <li><a href="/wiki/Glyceronephosphate_O-acyltransferase" title="Glyceronephosphate O-acyltransferase">Glyceronephosphate O-acyltransferase</a></li> <li><a href="/wiki/Lecithin%E2%80%94cholesterol_acyltransferase" class="mw-redirect" title="Lecithin—cholesterol acyltransferase">Lecithin—cholesterol acyltransferase </a></li></ul> <ul><li><a href="/wiki/Glycerol-3-phosphate_O-acyltransferase" title="Glycerol-3-phosphate O-acyltransferase">Glycerol-3-phosphate O-acyltransferase</a></li> <li><a href="/wiki/1-acylglycerol-3-phosphate_O-acyltransferase" title="1-acylglycerol-3-phosphate O-acyltransferase">1-acylglycerol-3-phosphate O-acyltransferase</a></li> <li><a href="/wiki/2-acylglycerol-3-phosphate_O-acyltransferase" title="2-acylglycerol-3-phosphate O-acyltransferase">2-acylglycerol-3-phosphate O-acyltransferase</a></li> <li><a href="/wiki/ABHD5" title="ABHD5">ABHD5</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_2)#EC_2.3.2:_Aminoacyltransferases" title="List of EC numbers (EC 2)">2.3.2</a>: <a href="/wiki/Aminoacyltransferase" title="Aminoacyltransferase">Aminoacyltransferases</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Gamma-glutamyl_transpeptidase" class="mw-redirect" title="Gamma-glutamyl transpeptidase">Gamma-glutamyl transpeptidase</a></li> <li><a href="/wiki/Peptidyl_transferase" class="mw-redirect" title="Peptidyl transferase">Peptidyl transferase</a></li> <li><a href="/wiki/Transglutaminase" title="Transglutaminase">Transglutaminase</a> <ul><li><a href="/wiki/Tissue_transglutaminase" title="Tissue transglutaminase">Tissue transglutaminase</a></li> <li><a href="/wiki/Keratinocyte_transglutaminase" title="Keratinocyte transglutaminase">Keratinocyte transglutaminase</a></li> <li><a href="/wiki/Factor_XIII" title="Factor XIII">Factor XIII</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_2)#EC_2.3.3:_Acyl_groups_converted_into_alkyl_on_transfer" title="List of EC numbers (EC 2)">2.3.3</a>: converted into alkyl on transfer</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Citrate_synthase" title="Citrate synthase">Citrate synthase</a></li> <li><a href="/wiki/Decylcitrate_synthase" title="Decylcitrate synthase">Decylcitrate synthase</a></li> <li><a href="/wiki/Citrate_(Re)-synthase" title="Citrate (Re)-synthase">Citrate (Re)-synthase</a></li> <li><a href="/wiki/Decylhomocitrate_synthase" title="Decylhomocitrate synthase">Decylhomocitrate synthase</a></li> <li><a href="/wiki/2-methylcitrate_synthase" title="2-methylcitrate synthase">2-methylcitrate synthase</a></li> <li><a href="/wiki/2-ethylmalate_synthase" title="2-ethylmalate synthase">2-ethylmalate synthase</a></li> <li><a href="/wiki/3-ethylmalate_synthase" title="3-ethylmalate synthase">3-ethylmalate synthase</a></li> <li><a href="/wiki/ATP_citrate_lyase" class="mw-redirect" title="ATP citrate lyase">ATP citrate lyase</a></li> <li><a href="/wiki/Malate_synthase" title="Malate synthase">Malate synthase</a></li> <li><a href="/wiki/Hydroxymethylglutaryl-CoA_synthase" title="Hydroxymethylglutaryl-CoA synthase">HMG-CoA synthase</a> <ul><li><a href="/wiki/HMGCS2" title="HMGCS2">HMGCS2</a></li></ul></li> <li><a href="/wiki/2-hydroxyglutarate_synthase" title="2-hydroxyglutarate synthase">2-hydroxyglutarate synthase</a></li> <li><a href="/wiki/3-propylmalate_synthase" title="3-propylmalate synthase">3-propylmalate synthase</a></li> <li><a href="/wiki/2-isopropylmalate_synthase" title="2-isopropylmalate synthase">2-isopropylmalate synthase</a></li> <li><a href="/wiki/Homocitrate_synthase" title="Homocitrate synthase">Homocitrate synthase</a></li> <li><a href="/wiki/Sulfoacetaldehyde_acetyltransferase" title="Sulfoacetaldehyde acetyltransferase">Sulfoacetaldehyde acetyltransferase</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Enzymes" title="Template:Enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Enzymes" title="Template talk:Enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Enzymes" title="Special:EditPage/Template:Enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Enzymes" style="font-size:114%;margin:0 4em"><a href="/wiki/Enzyme" title="Enzyme">Enzymes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Activity</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Active_site" title="Active site">Active site</a></li> <li><a href="/wiki/Binding_site" title="Binding site">Binding site</a></li> <li><a href="/wiki/Catalytic_triad" title="Catalytic triad">Catalytic triad</a></li> <li><a href="/wiki/Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li> <li><a href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a href="/wiki/Lyase" title="Lyase">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output .portal-bar-related{font-size:100%;justify-content:flex-start}.mw-parser-output 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role="note" class="metadata plainlinks asbox stub"><table role="presentation"><tbody><tr class="noresize"><td><p class="asbox-body">This <a href="/wiki/EC_2.3" class="mw-redirect" title="EC 2.3">EC 2.3</a> <a href="/wiki/Enzyme" title="Enzyme">enzyme</a>-related article is a <a href="/wiki/Wikipedia:Stub" title="Wikipedia:Stub">stub</a>. 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