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src="/images/librariesprovider5/template-images/24/header-mob.png?sfvrsn=30e988b0_3" alt="Discovery on Target 2024" /></a> </div></div> </div> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NKZ2R7R"height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div class="main-content"> <div id="cph1" class="container internal"> <div class="row"> <div class="row" data-sf-element="Row"> <div class="col-sm-9"> <div id="Contentplaceholder1_TDA1EA21B001_Col00" class="sf_colsIn pad-lr" data-sf-element="Column 1" data-placeholder-label="Column 1"> <div > <div class="sf-Long-text" ><p class="pageTitle">2024 Poster Presentations </p><p class="pageTitle"><i></i><i></i></p><p><b><u>POSTER SESSION A: Tuesday - Wednesday morning</u></b></p><p><b>A01: Enhancing Preclinical Toxicity Predictions: Leveraging Generative Models in Drug Development</b>, <i>Presented by Shuaib M., AbbVie</i></p><p><b>A02: Regulatory T Cell Interaction Within the Tumor Microenvironment: Targeting CCR8 for Enhanced Cancer Immunotherapy</b>, <i>Presented by Nari K., Asan Institute for Life Sciences</i></p><p><b>A03: A Proven Activity-Based Workflow for the Identification and Characterization of Time-Dependent Kinase Inhibitors Using a Continuous Assay Format</b>, <i>Presented by Earl M., AssayQuant Technologies, Inc.</i></p><p><b>A04: The Development and Application of a HiTChem Platform for Multiplexed Targeted Detection Using Fully Functionalized Photofragments</b>, <i>Presented by Yuanyuan S., AstraZeneca Pharmaceuticals</i></p><p><b>A05: A Novel Pan-RAS Inhibitor, ADT-1004, with Efficacy and Tolerability Advantages Over Other RAS Inhibitors to Suppress Tumor Growth in Multiple Mouse Models of Pancreatic Cancer</b>, <i>Presented by Gary P., Auburn University</i></p><p><b>A06: A Novel RAS/β-Catenin Inhibitor, ADT-030, Induces Tumor Regression and Inhibits Metastasis with “Cures” in Multiple Mouse Cancer Models</b>, <i>Presented by Gary P., Auburn University</i></p><p><b>A07: Zero-Shot Multi-Objective Antibody Evolution Using Multi-Agents</b>, <i>Presented by Wei L., Aureka Biotechnologies</i></p><p><b>A08: Rapid Engineering of GPCR Targeting Antibodies by Autonomous Hypermutation in Yeast</b>, <i>Presented by Alon W., Aureka Biotechnologies</i></p><p><b>A09: Discovery and Characterisation of a Novel TRPML1 Agonist</b>, <i>Presented by Angelo P., BioAscent Discovery Ltd.</i></p><p><b>A10: A Proven and Reliable Alpaca VHH Antibody Discovery Platform</b>, <i>Presented by Haoming Z., Biointron Biological USA, Inc.</i></p><p><b>A11: From Fragments, to Molecules to Approved Drugs: Easy Screening and Med Chem Support with the Carterra ULTRA HT-SPR and CarnaBio’s Biotinylated Kinome</b>, <i>Presented by Adam S., CarnaBio USA, Inc.</i></p><p><b>A12: The Development of a Novel Mobility Shift Analysis System for Kinase Small Molecule Drug Discovery Using the SCIEX BioPhase 8800</b>, <i>Presented by Adam S., CarnaBio USA, Inc.</i></p><p><b>A13: Selectivity and Cooperativity of PROTAC®s Using HT-SPR</b>, <i>Presented by Maria M., Carterra, Inc.</i></p><p><b>A14: Large-Scale Characterization of Drug Candidates Against Transmembrane Receptors Using HT-SPR</b>, <i>Presented by Maria M., Carterra, Inc.</i></p><p><b>A15: DELivering Mechanism of Inhibition Studies to Characterize Mutant Selective Kinase Inhibitors</b>, <i>Presented by Katherine J., Charles River Laboratories</i></p><p><b>A16: Structure-Based Charge Calculations for Predicting Properties and Profiling Antibody Therapeutics</b>, <i>Presented by Alain A., Chemical Computing Group</i></p><p><b>A17: Exploring the Dynamic Changes of Nucleic Acids to Evaluate the Effect of Protonated Nucleotides on Structure and Binding</b>, <i>Presented by Philippe A., Chemical Computing Group</i></p><p><b>A18: Discovering Ligands Targeting the Conserved RNA Binding Site of SARS CoV 2 NSP13 Using V-Synthes Approach: Cache Challenge 2</b>, <i>Presented by Olga T., Chemspace LLC</i></p><p><b>A19: Validation of a New Methodology to Create Orally Available Cyclic Peptides for Intracellular Tough Targets</b>, <i>Presented by Yugo K., Chugai Pharmaceutical Co., Ltd.</i></p><p><b>A20: New Modalities for 3D Virtual Screening of Ultra-Large Chemical Spaces</b>, <i>Presented by Sylvie S., Cresset</i></p><p><b>A21: Next Generation Copolymers for the Characterization of Membrane Proteins in Near-Native Conditions</b>, <i>Presented by Barbara M., Cube Biotech</i></p><p><b>A22: Domainex Hit ID Platform – Accelerated Workflow by a Partial PROTAC® Library and a Direct-to-Biology Approach</b>, <i>Presented by Ray B., Domainex Ltd.</i></p><p><b>A23: LC-MS Based Covalent Fragment Screening Strategy</b>, <i>Presented by Ray B., Domainex Ltd.</i></p><p><b>A24: Fragment Screening of Adenosine A2a Receptor Using Native Lipid Nanodiscs</b>, <i>Presented by Philip R., Domainex Ltd.</i></p><p><b>A25: Integral Membrane Proteins for Biophysics and Cryo-EM Applications – Case Study of the Ion Channel TrpML3</b>, <i>Presented by Philip R., Domainex Ltd.</i></p><p><b>A26: Affinity Selection Mass Spectrometry in Hit-Identification for Difficult-to-Drug Targets</b>, <i>Presented by Jean-Yves O., Edelris SAS</i></p><p><b>A27: Dual Applications of the SPRINTer Platform: Target Engagement and Targeted Protein Degradation Assay from Degrader Discovery to Functional Assay</b>, <i>Presented by Daniel B., Eurofins DiscoverX</i></p><p><b>A28: Comprehensive Helicase Solutions: Protein Production, Biochemical, Biophysical Assays, Selectivity Panel & Safety Assessment</b>, <i>Presented by Jean B., Eurofins Discovery</i></p><p><b>A29: LeadHunter STAT SH2 Binding Assays Enabling Novel Therapies for Cancer, Inflammation and Autoimmune Disease</b>, <i>Presented by Jean B., Eurofins Discovery</i></p><p><b>A30: AI/ML-Ab (Aim-Lab) AI Assisted De-Novo Design and Discovery</b>, <i>Presented by Richard B., Fusion Antibodies plc</i></p><p><b>A31: Mammalian Display for Antibody Discovery</b>, <i>Presented by Richard M., Fusion Antibodies plc</i></p><p><b>A32: Comparative Evaluation of Cell-Based Assay Technologies for Scoring Drug-Induced Condensation of SARS-CoV-2 Nucleocapsid Protein</b>, <i>Presented by Rui Tong Q., Harvard Medical School</i></p><p><b>A33: Offering a Hyper-Organized Library of Microbial Dark Matter Chemistry to Pharma Companies</b>, <i>Presented by Peter S., Helmholtz Institute for Pharmaceutical Research Saarland</i></p><p><b>A34: A WRN Screening Cascade to Facilitate Novel Drug Discovery</b>, <i>Presented by Cong H., ICE Bioscience</i></p><p><b>A35: DDR Cell Panel For Novel Drug Discovery</b>, <i>Presented by Cong H., ICE Bioscience</i></p><p><b>A36: Preclinical Safety Assessment for Specificity of Biotherapeutics Using the Membrane Proteome Array</b>, <i>Presented by Joseph R., Integral Molecular</i></p><p><b>A37: Critical Factors of Transmission of Antibiotic Resistance in Multidrug-Resistant Pathogens</b>, <i>Presented by Jung Hun L. and Sang Hee L., Myongji University</i></p><p><b>A38: Identification of a Novel Receptor-Mediated Transcytosis Target for the Generation of Single-Domain Antibodies as Therapeutic Carriers Across the Blood-Brain Barrier</b>, <i>Presented by Kasandra B., National Research Council Canada</i></p><p><b>A39: Identification and Characterization of Small Molecules Inhibiting RNA Targets: miRNA</b>, <i>Presented by Paola C., NovAliX</i></p><p><b>A40: PCKD, the Most Relevant Model for ADPKD</b>, <i>Presented by Laurent S., NovAliX</i></p><p><b>A41: Discovery and Characterization of Kv1.3 Antibodies using OmniChicken® and Ion Channel Technology Platforms</b>, <i>Presented by Allison G., OmniAb</i></p><p><b>A42: Kinase Activity Profiling Identified Role of Eph/Ephrin System in Molecular Subtyping of Colorectal Carcinoma Patient Derived Xenograft Models</b>, <i>Presented by Gitanjali D., PamGene International B.V.</i></p><p><b>A43: Integrated Proteomics, Metabolomics, and Transcriptomics Reveals Systemic and Localized Metabolic Disruptions in Colorectal Cancer</b>, <i>Presented by Tiffany B., PanomeBio</i></p><p><b>A44: Unbiased Selectivity Profiling - Cellular Thermal Shift Assay (CETSA) with MS Detection</b>, <i>Presented by Stina L., Pelago Bioscience</i></p><p><b>A45: G-Protein Toolbox and Other Strategies for a Focused Approach to Cryo-EM GPCR Projects</b>, <i>Presented by </i><i>Stephan K.</i><i>, Proteros biostructures GmbH</i></p><p><b>A46: Discovery and Characterization of Antibodies Against Challenging Membrane Protein Targets Using Salipro® Nano-Membrane Particles</b>, <i>Presented by Peter J., Salipro Biotech AB</i></p><p><b>A47: IL-17A and IL-23 Crystallization Systems Supporting Structure-Based Drug Design</b>, <i>Presented by Raymond K., SARomics Biostructures AB</i></p><p><b>A48: Discovery of First-in-Class Highly Selective Wee2 Inhibitors</b>, <i>Presented by Shelby E., Schroedinger, Inc.</i></p><p><b>A49V: Investigating Lymphatic Disorders, Malignancies and Naturopathic Management</b>, <i>Presented by David J., Sonoran University of Health Sciences</i></p><p><b>A50: The Discovery of a Novel Peptide Inhibitor Targeting Peptidoglycan-Induced Inflammation</b>, <i>Presented by MiYoung L., Soonchunhyang University</i></p><p><b>A51: The Discovery of an Inhibitor Against LPS and Peptidoglycan-Induced Muscle Atrophy</b>, <i>Presented by MiYoung L., Soonchunhyang University</i></p><p><b>A52: Discovering Better Hits: Advancing Drug Discovery Using Symeres’ SymeGold Library</b>, <i>Presented by Bart D., Symeres</i></p><p><b>A53: Development of a Novel MET Antibody-Drug Conjugate-Based Combination Therapy to Prevent Colorectal Cancer Plasticity and Drug Resistance</b>, <i>Presented by Shraddha S., University of Texas MD Anderson Cancer Center</i></p><p><b>A54: DELs in Cells: Direct Screening of DNA Encoded Libraries for PPI Inhibitors</b>, <i>Presented by Leif L., Vipergen Aps</i></p><p><b>A55: Discovery of Reversible Covalent Binders to Bfl-1 Using DNA-Encoded Chemical Libraries</b>, <i>Presented by Ying Z., X-Chem, Inc.</i></p><p><b>A56: Site Selective Screening: Using Biophysics to Define Mode of Action</b>, <i>Presented by Masakazu K., ZoBio BV</i></p><p><b> </b></p><p><b> </b></p><p><b><u>POSTER SESSION B: Wednesday afternoon - Thursday</u></b></p><p><b>B01: Discovery of Diverse GPCR-Targeted Antibodies Using Integrated Technologies</b>, <i>Presented by Kush D., AbCellera</i></p><p><b>B02: Discovery and Engineering of Bispecific Anti-CD3 Heavy Chain-Only Antibodies</b>, <i>Presented by Hannah W., Adimab LLC</i></p><p><b>B03: Mining Microorganisms for GPCR Ligands: Identification of LPA3 Agonism as a Key Modulator of Neuroinflammation by ADS024</b>, <i>Presented by Susan A., Adiso Therapeutics</i></p><p><b>B04: MegaR Technology Generates Stable, Ligand-Free, Pure GPCR Proteins and Structures for Drug Discovery</b>, <i>Presented by</i><i> Poonam V.</i><i>, Alphelix Biotech Co., Ltd.</i></p><p><b>B05: From Text to Genes: Can LLMs Enhance Expression Annotations?</b>, <i>Presented by Dawid R., Ardigen</i></p><p><b>B06: Development of A THP-1 Assay Ready Product for Cell-Based Assays</b>, <i>Presented by Diana D., ATCC (American Type Culture Collection)</i></p><p><b>B07: Predicting GPCR Signaling Efficacy and Understanding Mechanisms with Machine Learning</b>, <i>Presented by David C., Biagon, Inc.</i></p><p><b>B08: Accelerating Antibody Drug Development with Fully Humanized Mice</b>, <i>Presented by Lei S., Biointron Biological USA, Inc.</i></p><p><b>B09: Development of High Throughput Single-B Cell Antibody Discovery Platform</b>, <i>Presented by Huanyi Y., Biointron Biological USA, Inc.</i></p><p><b>B10: Enabling Research Tools for αβ and γδ T Cell-Based Immunotherapy</b>, <i>Presented by Michelle K., BPS Bioscience, Inc.</i></p><p><b>B11: Fragment-Based Drug Discovery (FBDD) Approach for IRAK4</b>, <i>Presented by Raniya A., Cayman Chemical Company</i></p><p><b>B12: MICRO-TAG™ Cell Target Engagement Platform from Discovery to Optimization</b>, <i>Presented by Elmar N., CellarisBio</i></p><p><b>B13: A Novel Real-Time Cellular Target Engagement Platform for Challenging Drug Targets</b>, <i>Presented by Elmar N., CellarisBio</i></p><p><b>B14: Discovery of Novel CHD4 Inhibitor to Regulate Foxp3+ Treg Cells and Enhance Immunotherapy</b>, <i>Presented by Elmar N., CellarisBio</i></p><p><b>B15: From Raw Dose Response Curves to Pharmacodynamic Classification: An Automatic Analysis Pipeline for GPCR Ligands</b>, <i>Presented by Derek R., Centre de Recherche du CHU Sainte-Justine</i></p><p><b>B16: A Rapid High-Throughput and Effective Process for Identifying Molecular Glues Using Affinity Selection Mass Spectrometry (ASMS)</b>, <i>Presented by Katherine J., Charles River Laboratories</i></p><p><b>B17: Development of a Ternary Complex Assay by SPR for PROTAC Drug Discovery</b>, <i>Presented by Sarah T., Charnwood Discovery</i></p><p><b>B18: Targeted Protein Degradation with Heterobifunctional Degraders: Modeling and Screening</b>, <i>Presented by Alain A., Chemical Computing Group</i></p><p><b>B19: Chemoproteomic Discovery and Preclinical Development of a Covalent Targeted Radioligand (CTR) Targeting Fibroblast Activation Protein (FAP)</b>, <i>Presented by Fengying Z., ChomiX Biotech Co., Ltd.</i></p><p><b>B20: Interpretable Machine Learning Uncovers Mechanisms Of Protein-Protein Coupling</b>, <i>Presented by Elizaveta M., City of Hope, Beckman Research Institute</i></p><p><b>B21: Introducing BioPALS – A Versatile Hit Identification Technology Powered by AI and Enabled by GCI</b>, <i>Presented by Jamie S., Concept Life Sciences</i></p><p><b>B22: FragAI: Unlocking Chemical Matter Using “Crystal Structure First” Approach and Generative AI</b>, <i>Presented by Serghei G., CrystalsFirst GmbH</i></p><p><b>B23: Preclinical Validation of γ-Secretase Modulator GSM 776890 for Alzheimer’s Disease Prevention</b>, <i>Presented by Ronald B., Curia</i></p><p><b>B24: Moving the Scale for Obesity Therapeutics – From Bench to Bedside: Functional Cell-based Assays for GLP-1, GIP, & Beyond</b>, <i>Presented by Raghu B., Eurofins DiscoverX</i></p><p><b>B25: Hands-off Screening with Cells: Automation of a Cellular Biosensor to Facilitate Efficient Hit Compound Screening</b>, <i>Presented by Laura T., Exscientia Ltd.</i></p><p><b>B26: Rapid Protein Proteolysis Inducer Discobery System, RaPPIDS, Advancing Degrader Discovery by Two Different Approaches</b>, <i>Presented by Kazuteru A., FIMECS, Inc.</i></p><p><b>B27: Investigating Structure and Dynamics of Biologically Relevant Macromolecules Through EPR Distance Measurements</b>, <i>Presented by Austin GJ., High Q Technologies, Inc.</i></p><p><b>B28: Anti-Obesity Related Target Assay Development and Application</b>, <i>Presented by TJ B., ICE Bioscience</i></p><p><b>B29: Structural Analysis and Epitope Mapping of Membrane Proteins in Live Cells with Amino-Acid Resolution and High-Throughput</b>, <i>Presented by Hetal M., Immuto Scientific</i></p><p><b>B30: GLP-1R and GIPR Cell-Based Reporter Assays: New Tools to Advance the Development of Therapeutics for Type II Diabetes and Obesity</b>, <i>Presented by Andrew W., </i><i>INDIGO Biosciences, Inc.</i></p><p><b>B31: Next Generation Gene Design Using codABLE™ Algorithm</b>, <i>Presented by Masha K., Ingenza Ltd.</i></p><p><b>B32: Discovery and Development of the Small Molecule Antiviral Against Pan-Coronavirus Using Phenotypic High Throughput Screening</b>, <i>Presented by BoRa L., Institut Pasteur Korea</i></p><p><b>B33: Causal Modelling of Sjogren’s Disease Using Swarm Based Deep Learning for Therapeutic Target Identification</b>, <i>Presented by Robert G., Intelligent OMICS Ltd.</i></p><p><b>B34: Discovering Novel Drugs by Targeting Ubiquitin Proteasome System for PROTACs and Molecular Glues</b>, <i>Presented by Karteek K., LifeSensors, Inc.</i></p><p><b>B35: Superior Luciferase Reporter System to Discover Targeted Protein Degradation Drugs</b>, <i>Presented by Karteek K., LifeSensors, Inc.</i></p><p><b>B36: Optimization of Ghrelin Receptor Bias Modulators for the Treatment of Addictive Disorders</b>, <i>Presented by Konstantinos A., National Institutes of Health, National Center for Advancing Translational Sciences</i></p><p><b>B37: Chemogenomic Screens Identify Chemical Entities for the Activation of Delta-Globin Gene Expression</b>, <i>Presented by Sinead C., National Institutes of Health, National Center for Advancing Translational Sciences</i></p><p><b>B38: NIH Blueprint Neurotherapeutics Network (BPN): Funding and Resources for the Discovery of Novel Drug Candidates for the Treatment of Neurological Disorders</b>, <i>Presented by Enrique M., National Institutes of Health, National Institute of Mental Health</i></p><p><b>B39: Integrating Single-Particle Cryo-Electron Microscopy and Hydrogen/ Deuterium Exchange Mass Spectrometry to Elucidate the Structure and Dynamics of G-Protein Coupled Receptors</b>, <i>Presented by Paola C., NovAliX</i></p><p><b>B40: Screen, Scale, Capture, Characterize: Rapid Functional Protein Production and Characterization of Drug-Target Interactions</b>, <i>Presented by Aujan M., Nuclera</i></p><p><b>B41: Cell Free Expression of E3 Ubiquitin Ligases to Accelerate Target Protein Degradation Studies</b>, <i>Presented by Yvonne T., Nuclera</i></p><p><b>B42: Integration of Untargeted Metabolomics with Targeted Profiling of Inflammatory Proteins to Define the Metabolic Fingerprint of Inflammation in COVID-19</b>, <i>Presented by Arnold S., PanomeBio</i></p><p><b>B43: A Mechanical Delivery Platform Enabling Intracellular Delivery of Impermeable Small Molecules, Peptides, and Probes for Enhanced Drug Discovery</b>, <i>Presented by Jacquelyn H., Portal Biotechnologies</i></p><p><b>B44: A Bioluminescent, Homogeneous Assay for Monitoring GPCR-Mediated cAMP Modulation and Adenylate Cyclase Activity</b>, <i>Presented by Kristin H., Promega Corporation</i></p><p><b>B45: Exploring the Landscape of PARP and PARG inhibitor Selectivity in Live Cells Using NanoBRET™ Target Engagement Assays</b>, <i>Presented by Alissa K., Promega Corporation</i></p><p><b>B46: HiBiT Protein Tagging System to Study Protein Interactions at Endogenous Levels</b>, <i>Presented by Amy L., Promega Corporation</i></p><p><b>B47: Advancing Therapeutic Strategies for Obesity: Innovative Bioluminescent Assays for Monitoring GPCR Dynamics</b>, <i>Presented by Megan L., Promega Corporation</i></p><p><b>B48: Novel Drug Discovery Platform Based on Quantum Computing and AI</b>, <i>Presented by Sungmin L., Qunova Computing, Inc.</i></p><p><b>B49: Quantum Computing Approaches for Enhancing Molecule Discovery in Qunova Computing</b>, <i>Presented by Jaehong S., Qunova Computing, Inc.</i></p><p><b>B50: Filling the Gap in LogP and pKa Evaluation for Saturated Fluorine-Containing Derivatives with Machine Learning</b>, <i>Presented by Oleksandr G., </i><i>Lviv Polytechnic National University</i></p><p><b>B51: An Integrated Text-Mining and Network Modeling Approach for Target Identification Validated in MASH-Induced Liver Fibrosis</b>, <i>Presented by Jennifer MV., TNO Nutrition and Food Research</i></p><p><b>B52: TargetTri: Automated Classification of Target Modulation and Associated Effects in PubMed Using BERT-Based Models</b>, <i>Presented by Jennifer MV., TNO Nutrition and Food Research</i></p><p><b>B53: Developing Robust Cell-Based Assays to Evaluate Efficacy of MYC-PNUTS Inhibitors</b>, <i>Presented by Melissa S., University Health Network</i></p><p><b>B54: DEL Screening Methods to Find High-Quality and Structurally Diverse Novel Hits as Starting Points for New GPCR Modulators</b>, <i>Presented by Anthony K., X-Chem, Inc.</i></p><p><b>B55: Phospho-Ubiquitin: A Biomarker for Neurodegeneration</b>, <i>Presented by Tauseef B., Progenra, Inc.</i></p><p><b>B56: Benchmarking OpenMM on 25 Different Consumer GPUs at 95% Less Cost</b>, <i>Presented by Bob M., Salad Technologies</i></p><div><b>B57: Combining Advanced Peptide Screening Methods to Identify Macrocyclic Peptide Candidates for PDC/RDC/POC Development</b>, <i>Presented by Weiliang X., Zonsen Peplib Biotech</i> </div><div><br /></div><p></p><p> </p><p> </p><p><i> </i></p><p> </p><p> </p></div> </div></div> </div> <div class="col-sm-3"> <div id="Contentplaceholder1_TDA1EA21B001_Col01" class="sf_colsIn pad-lr" data-sf-element="Column 2" data-placeholder-label="Column 2"><div class='sfContentBlock'> <br class="hidden-sm hidden-md hidden-lg" /><div class="social-icons"><a target="_blank" href="/docs/librariesprovider5/og/discovery-on-target_2024.ics?sfvrsn=5a8c1984_3&download=true" title="Outlook"><img src="/images/default-source/social/calendar-gray.png?sfvrsn=91696e36_6" title="Outlook" alt="Outlook" class="social-icon" /></a> <a href="http://www.youtube.com/user/CambridgeHealthtech" target="_blank" title="YouTube"><img 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