Type II Interferon Signaling Pathways

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data-form="pathways_il-21_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-27_p28_il-30_signaling_pathways" action="/pathways/il-27-p28il-30-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-27-p28il-30-signaling-pathways" class="pathway_link" data-form="pathways_il-27_p28_il-30_signaling_pathways"> IL-27 p28/IL-30 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-31_signaling_pathways" action="/pathways/il-31-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-31-signaling-pathways" class="pathway_link" data-form="pathways_il-31_signaling_pathways"> IL-31 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-4_signaling_pathways" action="/pathways/il4-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il4-signaling-pathways" class="pathway_link" data-form="pathways_il-4_signaling_pathways"> IL-4 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-4_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-4-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-4-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-4_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-6_signaling_pathways" action="/pathways/il-6-family-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-6-family-signaling-pathways" class="pathway_link" data-form="pathways_il-6_signaling_pathways"> IL-6 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-7_signaling_pathways" action="/pathways/il7-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il7-signaling-pathways" class="pathway_link" data-form="pathways_il-7_signaling_pathways"> IL-7 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-7_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-7-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-7-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-7_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-9_signaling_pathways" action="/pathways/il9-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il9-signaling-pathways" class="pathway_link" data-form="pathways_il-9_signaling_pathways"> IL-9 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-9_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-9-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-9-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-9_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_inflammasome_activation_pathways" action="/pathways/inflammasome-activation-pathways" method="post"> <li class=""> <a href="/pathways/inflammasome-activation-pathways" class="pathway_link" data-form="pathways_inflammasome_activation_pathways"> Inflammasome Activation Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_innate_lymphoid_cell_differentiation_pathways" action="/pathways/innate-lymphoid-cell-differentiation-pathways" method="post"> <li class=""> <a href="/pathways/innate-lymphoid-cell-differentiation-pathways" class="pathway_link" data-form="pathways_innate_lymphoid_cell_differentiation_pathways"> Innate Lymphoid Cell Differentiation Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_lif_signaling_pathways" action="/pathways/lif-signaling-pathways" method="post"> <li class=""> <a href="/pathways/lif-signaling-pathways" class="pathway_link" data-form="pathways_lif_signaling_pathways"> LIF Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mdsc-mediated_mechanisms_of_immunosuppression" action="/pathways/mdsc-mediated-mechanisms-of-immunosuppression" method="post"> <li class=""> <a href="/pathways/mdsc-mediated-mechanisms-of-immunosuppression" class="pathway_link" data-form="pathways_mdsc-mediated_mechanisms_of_immunosuppression"> MDSC-Mediated Mechanisms of Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_regulatory_t_cell-mediated_suppression" action="/pathways/mechanisms-of-regulatory-t-cell-mediated-suppression" method="post"> <li class=""> <a href="/pathways/mechanisms-of-regulatory-t-cell-mediated-suppression" class="pathway_link" data-form="pathways_mechanisms_of_regulatory_t_cell-mediated_suppression"> Mechanisms of Regulatory T Cell-Mediated Suppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_tumor-associated_macrophage_tam-mediated_immunosuppression" action="/pathways/tumor-associated-macrophage-tam" method="post"> <li class=""> <a href="/pathways/tumor-associated-macrophage-tam" class="pathway_link" data-form="pathways_mechanisms_of_tumor-associated_macrophage_tam-mediated_immunosuppression"> Mechanisms of Tumor-Associated Macrophage TAM-Mediated Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_tumor-derived_exosome_tex-mediated_immunosuppression" action="/pathways/mechanisms-tumor-derived-exosome-tex-mediated-immunosuppression" method="post"> <li class=""> <a href="/pathways/mechanisms-tumor-derived-exosome-tex-mediated-immunosuppression" class="pathway_link" data-form="pathways_mechanisms_of_tumor-derived_exosome_tex-mediated_immunosuppression"> Mechanisms of Tumor-derived Exosome TEX-mediated Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_natural_killer_cell_receptors__human_target_cell_–_nk_cell_ligand-receptor_interactions" action="/pathways/natural-killer-cell-receptors-human-target-cell-nk-cell-ligand-receptor-interactions-pathway" method="post"> <li class=""> <a href="/pathways/natural-killer-cell-receptors-human-target-cell-nk-cell-ligand-receptor-interactions-pathway" class="pathway_link" data-form="pathways_natural_killer_cell_receptors__human_target_cell_–_nk_cell_ligand-receptor_interactions"> Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_neuropoietin_signaling_pathways" action="/pathways/neuropoietin-signaling-pathways" method="post"> <li class=""> <a href="/pathways/neuropoietin-signaling-pathways" class="pathway_link" data-form="pathways_neuropoietin_signaling_pathways"> Neuropoietin Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_nod-like_receptor_signaling_pathways" action="/pathways/nod-like-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/nod-like-receptor-signaling-pathways" class="pathway_link" data-form="pathways_nod-like_receptor_signaling_pathways"> NOD-like Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_oncostatin_m_signaling_pathways" action="/pathways/oncostatin-m-signaling-pathways" method="post"> <li class=""> <a href="/pathways/oncostatin-m-signaling-pathways" class="pathway_link" data-form="pathways_oncostatin_m_signaling_pathways"> Oncostatin M Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_pathogen_or_damage-activated_c-type_lectin_receptor_signaling_pathways" action="/pathways/pathogen-damage-activated-c-type-lectin-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/pathogen-damage-activated-c-type-lectin-receptor-signaling-pathways" class="pathway_link" data-form="pathways_pathogen_or_damage-activated_c-type_lectin_receptor_signaling_pathways"> Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_t_cell_co-signaling_pathway__ligand-receptor_interactions" action="/pathways/t-cell-co-signaling-pathway-lig-recept-interactions" method="post"> <li class=""> <a href="/pathways/t-cell-co-signaling-pathway-lig-recept-interactions" class="pathway_link" data-form="pathways_t_cell_co-signaling_pathway__ligand-receptor_interactions"> T Cell Co-Signaling Pathway: Ligand-Receptor Interactions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_tgf-beta_signaling_pathways" action="/pathways/tgf-beta-signaling-pathways" method="post"> <li class=""> <a href="/pathways/tgf-beta-signaling-pathways" class="pathway_link" data-form="pathways_tgf-beta_signaling_pathways"> TGF-beta Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th1_differentiation_pathway" action="/pathways/th1-differentiation-pathway" method="post"> <li class=""> <a href="/pathways/th1-differentiation-pathway" class="pathway_link" data-form="pathways_th1_differentiation_pathway"> Th1 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th17_differentiation_pathway" action="/pathways/th17-differentiation-pathway" method="post"> <li class=""> <a href="/pathways/th17-differentiation-pathway" class="pathway_link" data-form="pathways_th17_differentiation_pathway"> Th17 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th2_differentiation_pathway" action="/pathways/th2-differentiation-pathway" method="post"> <li class=""> <a href="/pathways/th2-differentiation-pathway" class="pathway_link" data-form="pathways_th2_differentiation_pathway"> Th2 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_tnf_superfamily_pathway__human_ligand-receptor_interactions__their_associated_functions" action="/pathways/tnf-superfamily-pathway-human-lig-recept-interactions-their-associated-functions" method="post"> <li class=""> <a href="/pathways/tnf-superfamily-pathway-human-lig-recept-interactions-their-associated-functions" class="pathway_link" data-form="pathways_tnf_superfamily_pathway__human_ligand-receptor_interactions__their_associated_functions"> TNF Superfamily Pathway: Human Ligand-Receptor Interactions & their Associated Functions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_toll-like_receptor_signaling_pathways" action="/pathways/toll-like-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/toll-like-receptor-signaling-pathways" class="pathway_link" data-form="pathways_toll-like_receptor_signaling_pathways"> Toll-Like Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_i_interferon_signaling_pathways" action="/pathways/type-i-interferon-signaling-pathways" method="post"> <li class=""> <a href="/pathways/type-i-interferon-signaling-pathways" class="pathway_link" data-form="pathways_type_i_interferon_signaling_pathways"> Type I Interferon Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_ii_interferon_signaling_pathways" action="/pathways/type-ii-interferon-signaling-pathways" method="post"> <li class="active"> <a href="/pathways/type-ii-interferon-signaling-pathways" class="pathway_link" data-form="pathways_type_ii_interferon_signaling_pathways"> Type II Interferon Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_iii_interferon_signaling_pathways" action="/pathways/type-iii-interferon-signaling-pathways" method="post"> <li class=""> <a href="/pathways/type-iii-interferon-signaling-pathways" class="pathway_link" data-form="pathways_type_iii_interferon_signaling_pathways"> Type III Interferon Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_vegf_-_vegf_r2_signaling_pathways" action="/pathways/vegf-vegf-r2-signaling-pathways" method="post"> <li class=""> <a href="/pathways/vegf-vegf-r2-signaling-pathways" class="pathway_link" data-form="pathways_vegf_-_vegf_r2_signaling_pathways"> VEGF - VEGF R2 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_virus_detection_and_induction_of_antiviral_signaling_pathways_by_rig-i-like_receptors_rlr" action="/pathways/rig-i-like-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/rig-i-like-receptor-signaling-pathways" class="pathway_link" data-form="pathways_virus_detection_and_induction_of_antiviral_signaling_pathways_by_rig-i-like_receptors_rlr"> Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors RLR </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> </ul> </li> <li class="pathways-li "> <form id="pathways_neuroscience_pathways" action="/pathways/neuroscience" method="post"> <a href="/pathways/neuroscience" data-form="pathways_neuroscience_pathways" class="pathway_link"> <span class="icon-"> Neuroscience Pathways </span> </a> <input type="hidden" name="pw_parent" value="Neuroscience"> </form> </li> <li class="pathways-li "> <form id="pathways_proteases__other_enzymes_pathways" action="/pathways/proteases" method="post"> <a href="/pathways/proteases" data-form="pathways_proteases__other_enzymes_pathways" class="pathway_link"> <span class="icon-"> Proteases & Other Enzymes Pathways </span> </a> <input type="hidden" name="pw_parent" value="proteases"> </form> </li> <li class="pathways-li "> <form id="pathways_signal_transduction_pathways" action="/pathways/signal-transduction" method="post"> <a href="/pathways/signal-transduction" data-form="pathways_signal_transduction_pathways" class="pathway_link"> <span class="icon-"> Signal Transduction Pathways </span> </a> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> </li> <li class="pathways-li "> <form id="pathways_stem_cell_pathways" action="/pathways/stem-cells" method="post"> <a href="/pathways/stem-cells" data-form="pathways_stem_cell_pathways" class="pathway_link"> <span class="icon-"> Stem Cell Pathways </span> </a> <input type="hidden" name="pw_parent" value="stem-cells"> </form> </li> <li class="pathways-li "> <form id="pathways_ubiquitin_related_modifiers__pathways" action="/pathways/ubiquitin-related-modifiers-and-pathways" method="post"> <a href="/pathways/ubiquitin-related-modifiers-and-pathways" data-form="pathways_ubiquitin_related_modifiers__pathways" class="pathway_link"> <span class="icon-"> Ubiquitin, Related Modifiers, & Pathways </span> </a> <input type="hidden" name="pw_parent" value="ubiquitin-related-modifiers-and-pathways"> </form> </li> </ul> </div> </div> </div> </div> </div> <div class="pw_right col-xs-12 col-sm-8 col-md-9"> <div class="search_mobile_buttons"> <div class="pw_menu_toggle btn btn-tertiary">Show Categories</div> </div> <div class="pw_header"> <h1>Type II Interferon Signaling Pathways</h1> <p id="pw-intro-txt">Click on the links shown in the Explore Pathways box below to see the signaling pathways that are activated by members of either the type I or type III interferon families.<br></p> <div id="pw-con" data-mapname="" data-primary_segment=""> <div id="pw-main-nav-wrapper"> <div class="row"> <div id="pw-button-nav-top" class="col-xs-12 col-sm-12"> <div class="row"> <div id="pw-button-nav"> <div class="dropdown col-xs-12 col-sm-6 col-md-4"> <button class="btn-pw" type="button" data-toggle="dropup">Explore Pathways<span class="caret"></span></button> <ul id="pathwaynav" class="dropdown-content"><li class="pw_rdblue_sm pw_sm_btn"><a href="/pathways/type-i-interferon-signaling-pathways"><span>Type I Interferons</span></a></li> <li class="pw_sm_btn-active"><a href="/pathways/type-ii-interferon-signaling-pathways"><span>Type II Interferons</span></a></li> <li class="pw_rdblue_sm pw_sm_btn"><a href="/pathways/type-iii-interferon-signaling-pathways"><span>Type III Interferons</span></a></li> </ul> </div> </div> <div class="col-xs-12 col-sm-6 col-md-5" > <div id="pw-nav-subtitle"> Type II Interferon Signaling Pathways </div> </div> <div id="pw-print-button-col" class="col-xs-12 col-sm-6 col-md-3" > <a href="#print-copy-form" id="btn-get-print-copy" class="btn btn-primary"><img class="btn-icon" src="https://resources.rndsystems.com/images/Pathways/icons/icon-image.svg"/> Get Print Copy</a> </div> </div> </div> </div> </div> <div id="pw-map"> <div id="pw-maps"> <div id="el1_gry" class="type_ii_ifn_signaling pw-sprite el-gray1 pw-gray" style="top:18px;left:343px;"> </div> <div id="el1_off" data-id="1" data-set="TypeIIIFN60" data-type="" class="type_ii_ifn_signaling pw-sprite el-off1" style="top:18px;left:343px;"> </div> <div id="el1_ct" class="pw-tooltip" data-id="1"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma">IFN-gamma</a><br> </div> </div> <div id="el2_gry" class="type_ii_ifn_signaling pw-label el-gray2 pw-gray" style="top:8px;left:341px;"> Type II IFN </div> <div id="el2_off" data-id="2" data-set="TypeIIIFN60" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off2" style="top:8px;left:341px;"> Type II IFN</div> <div id="el2_ct" class="pw-tooltip" data-id="2"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma">IFN-gamma</a><br> </div> </div> <div id="el3_gry" class="type_ii_ifn_signaling pw-sprite el-gray3 pw-gray" style="top:31px;left:324px;"> </div> <div id="el3_off" data-id="3" data-set="IFN-gammaR1CD11962" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off3" style="top:31px;left:324px;"> </div> <div id="el3_ct" class="pw-tooltip" data-id="3"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma-r2">IFN-gamma R2</a><br> </div> </div> <div id="el4_gry" class="type_ii_ifn_signaling pw-label el-gray4 pw-gray" style="top:72px;left:417px;"> IFN-gamma R2 </div> <div id="el4_off" data-id="4" data-set="IFN-gammaR1CD11962" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off4" style="top:72px;left:417px;"> IFN-gamma R2</div> <div id="el4_ct" class="pw-tooltip" data-id="4"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma-r2">IFN-gamma R2</a><br> </div> </div> <div id="el5_gry" class="type_ii_ifn_signaling pw-sprite el-gray5 pw-gray" style="top:31px;left:340px;"> </div> <div id="el5_off" data-id="5" data-set="IFN-gammaR261" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off5" style="top:31px;left:340px;"> </div> <div id="el5_ct" class="pw-tooltip" data-id="5"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma-r1-cd119">IFN-gamma R1</a><br> </div> </div> <div id="el6_gry" class="type_ii_ifn_signaling pw-label el-gray6 pw-gray" style="top:71px;left:201px;"> IFN-gamma R1/CD119 </div> <div id="el6_off" data-id="6" data-set="IFN-gammaR261" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off6" style="top:71px;left:201px;"> IFN-gamma R1/CD119</div> <div id="el6_ct" class="pw-tooltip" data-id="6"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-gamma-r1-cd119">IFN-gamma R1</a><br> </div> </div> <div id="el7_gry" class="type_ii_ifn_signaling pw-sprite el-gray7 pw-gray" style="top:145px;left:326px;"> </div> <div id="el7_off" data-id="7" data-set="Jak263" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off7" style="top:145px;left:326px;"> </div> <div id="el7_ct" class="pw-tooltip" data-id="7"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak2">Jak2</a><br> </div> </div> <div id="el8_gry" class="type_ii_ifn_signaling pw-label el-gray8 pw-gray" style="top:156px;left:301px;"> Jak2 </div> <div id="el8_off" data-id="8" data-set="Jak263" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off8" style="top:156px;left:301px;"> Jak2</div> <div id="el8_ct" class="pw-tooltip" data-id="8"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak2">Jak2</a><br> </div> </div> <div id="el9_gry" class="type_ii_ifn_signaling pw-sprite el-gray9 pw-gray" style="top:162px;left:349px;"> </div> <div id="el9_off" data-id="9" data-set="Jak164" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off9" style="top:162px;left:349px;"> </div> <div id="el9_ct" class="pw-tooltip" data-id="9"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> </div> </div> <div id="el10_gry" class="type_ii_ifn_signaling pw-label el-gray10 pw-gray" style="top:189px;left:360px;"> Jak1 </div> <div id="el10_off" data-id="10" data-set="Jak164" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off10" style="top:189px;left:360px;"> Jak1</div> <div id="el10_ct" class="pw-tooltip" data-id="10"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> </div> </div> <div id="el11_gry" class="type_ii_ifn_signaling pw-sprite el-gray11 pw-gray" style="top:144px;left:383px;"> </div> <div id="el11_off" data-id="11" data-set="Jak265" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off11" style="top:144px;left:383px;"> </div> <div id="el11_ct" class="pw-tooltip" data-id="11"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak2">Jak2</a><br> </div> </div> <div id="el12_gry" class="type_ii_ifn_signaling pw-label el-gray12 pw-gray" style="top:155px;left:415px;"> Jak2 </div> <div id="el12_off" data-id="12" data-set="Jak265" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off12" style="top:155px;left:415px;"> Jak2</div> <div id="el12_ct" class="pw-tooltip" data-id="12"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak2">Jak2</a><br> </div> </div> <div id="el13_gry" class="type_ii_ifn_signaling pw-sprite el-gray13 pw-gray" style="top:238px;left:174px;"> </div> <div id="el13_off" data-id="13" data-set="IRS1266" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off13" style="top:238px;left:174px;"> </div> <div id="el13_ct" class="pw-tooltip" data-id="13"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/irs1">IRS1</a><br><a target="_blank" href="/target/irs2">IRS2</a><br> </div> </div> <div id="el14_gry" class="type_ii_ifn_signaling pw-label el-gray14 pw-gray" style="top:246px;left:137px;"> IRS1/2 </div> <div id="el14_off" data-id="14" data-set="IRS1266" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off14" style="top:246px;left:137px;"> IRS1/2</div> <div id="el14_ct" class="pw-tooltip" data-id="14"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/irs1">IRS1</a><br><a target="_blank" href="/target/irs2">IRS2</a><br> </div> </div> <div id="el15_gry" class="type_ii_ifn_signaling pw-sprite el-gray15 pw-gray" style="top:257px;left:172px;"> </div> <div id="el15_off" data-id="15" data-set="PI3-K67" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off15" style="top:257px;left:172px;"> </div> <div id="el15_ct" class="pw-tooltip" data-id="15"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/pi-3-kinase-p85-alpha">PI 3-Kinase p85 alpha</a><br><a target="_blank" href="/target/pi-3-kinase-p110-beta">PI 3-Kinase p110 beta</a><br><a target="_blank" href="/target/pi-3-kinase-p110-gamma">PI 3-Kinase p110 gamma</a><br><a target="_blank" href="/target/pi-3-kinase-p110-delta">PI 3-Kinase p110 delta</a><br><a target="_blank" href="/target/pi-3-kinase-p85-beta">PI 3-Kinase p85 beta</a><br><a target="_blank" href="/search?keywords=pi3k">All PI 3-K Products</a><br> </div> </div> <div id="el16_gry" class="type_ii_ifn_signaling pw-label el-gray16 pw-gray" style="top:270px;left:140px;"> PI 3-K </div> <div id="el16_off" data-id="16" data-set="PI3-K67" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off16" style="top:270px;left:140px;"> PI 3-K</div> <div id="el16_ct" class="pw-tooltip" data-id="16"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/pi-3-kinase-p85-alpha">PI 3-Kinase p85 alpha</a><br><a target="_blank" href="/target/pi-3-kinase-p110-beta">PI 3-Kinase p110 beta</a><br><a target="_blank" href="/target/pi-3-kinase-p110-gamma">PI 3-Kinase p110 gamma</a><br><a target="_blank" href="/target/pi-3-kinase-p110-delta">PI 3-Kinase p110 delta</a><br><a target="_blank" href="/target/pi-3-kinase-p85-beta">PI 3-Kinase p85 beta</a><br><a target="_blank" href="/search?keywords=pi3k">All PI 3-K Products</a><br> </div> </div> <div id="el17_gry" class="type_ii_ifn_signaling pw-sprite el-gray17 pw-gray" style="top:310px;left:176px;"> </div> <div id="el17_off" data-id="17" data-set="Akt68" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off17" style="top:310px;left:176px;"> </div> <div id="el17_ct" class="pw-tooltip" data-id="17"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/akt">Akt</a><br><a target="_blank" href="/target/akt1">Akt1</a><br><a target="_blank" href="/target/akt2">Akt2</a><br><a target="_blank" href="/target/akt3">Akt3</a><br> </div> </div> <div id="el18_gry" class="type_ii_ifn_signaling pw-label el-gray18 pw-gray" style="top:320px;left:183px;"> Akt </div> <div id="el18_off" data-id="18" data-set="Akt68" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off18" style="top:320px;left:183px;"> Akt</div> <div id="el18_ct" class="pw-tooltip" data-id="18"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/akt">Akt</a><br><a target="_blank" href="/target/akt1">Akt1</a><br><a target="_blank" href="/target/akt2">Akt2</a><br><a target="_blank" href="/target/akt3">Akt3</a><br> </div> </div> <div id="el19_gry" class="type_ii_ifn_signaling pw-sprite el-gray19 pw-gray" style="top:360px;left:138px;"> </div> <div id="el19_off" data-id="19" data-set="IKK-beta69" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off19" style="top:360px;left:138px;"> </div> <div id="el19_ct" class="pw-tooltip" data-id="19"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ikk-beta">IKK beta</a><br> </div> </div> <div id="el20_gry" class="type_ii_ifn_signaling pw-label el-gray20 pw-gray" style="top:372px;left:123px;"> IKK-beta </div> <div id="el20_off" data-id="20" data-set="IKK-beta69" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off20" style="top:372px;left:123px;"> IKK-beta</div> <div id="el20_ct" class="pw-tooltip" data-id="20"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ikk-beta">IKK beta</a><br> </div> </div> <div id="el21_gry" class="type_ii_ifn_signaling pw-sprite el-gray21 pw-gray" style="top:333px;left:44px;"> </div> <div id="el21_off" data-id="21" data-set="Proteasome73" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off21" style="top:333px;left:44px;"> </div> <div id="el21_ct" class="pw-tooltip" data-id="21"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/26s-proteasome">26S Proteasome</a><br><a target="_blank" href="/target/19s-proteasome">19S Proteasome</a><br><a target="_blank" href="/target/20s-proteasome">20S Proteasome</a><br><a target="_blank" href="/target/proteasome-inhibitors">proteasome inhibitors</a><br><a target="_blank" href="/target/proteasome-substrates">proteasome substrates</a><br> </div> </div> <div id="el22_gry" class="type_ii_ifn_signaling pw-label el-gray22 pw-gray" style="top:346px;left:96px;"> I kappa B </div> <div id="el22_off" data-id="22" data-set="IkappaB70" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off22" style="top:346px;left:96px;"> I kappa B</div> <div id="el22_ct" class="pw-tooltip" data-id="22"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ikb-alpha">IkB-alpha</a><br><a target="_blank" href="/target/ikb-beta">IkB-beta</a><br><a target="_blank" href="/target/ikb-epsilon">IkB-epsilon</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el23_gry" class="type_ii_ifn_signaling pw-sprite el-gray23 pw-gray" style="top:403px;left:19px;"> </div> <div id="el23_off" data-id="23" data-set="NF-kappaB71" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off23" style="top:403px;left:19px;"> </div> <div id="el23_ct" class="pw-tooltip" data-id="23"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/nfkb1">NFkB1</a><br><a target="_blank" href="/target/nfkb2">NFkB2</a><br><a target="_blank" href="/target/rela-nfkb-p65">RelA/NFkB p65</a><br><a target="_blank" href="/target/relb">RelB</a><br><a target="_blank" href="/target/c-rel">c-Rel</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el24_gry" class="type_ii_ifn_signaling pw-label el-gray24 pw-gray" style="top:417px;left:15px;"> NF-kappa B </div> <div id="el24_off" data-id="24" data-set="NF-kappaB71" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off24" style="top:417px;left:15px;"> NF-kappa B</div> <div id="el24_ct" class="pw-tooltip" data-id="24"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/nfkb1">NFkB1</a><br><a target="_blank" href="/target/nfkb2">NFkB2</a><br><a target="_blank" href="/target/rela-nfkb-p65">RelA/NFkB p65</a><br><a target="_blank" href="/target/relb">RelB</a><br><a target="_blank" href="/target/c-rel">c-Rel</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el25_gry" class="type_ii_ifn_signaling pw-sprite el-gray25 pw-gray" style="top:392px;left:35px;"> </div> <div id="el25_off" data-id="25" data-set="IkappaB72" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off25" style="top:392px;left:35px;"> </div> <div id="el25_ct" class="pw-tooltip" data-id="25"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ikb-alpha">IkB-alpha</a><br><a target="_blank" href="/target/ikb-beta">IkB-beta</a><br><a target="_blank" href="/target/ikb-epsilon">IkB-epsilon</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el26_gry" class="type_ii_ifn_signaling pw-label el-gray26 pw-gray" style="top:399px;left:3px;"> I kappa B </div> <div id="el26_off" data-id="26" data-set="IkappaB72" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off26" style="top:399px;left:3px;"> I kappa B</div> <div id="el26_ct" class="pw-tooltip" data-id="26"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ikb-alpha">IkB-alpha</a><br><a target="_blank" href="/target/ikb-beta">IkB-beta</a><br><a target="_blank" href="/target/ikb-epsilon">IkB-epsilon</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el27_gry" class="type_ii_ifn_signaling pw-sprite el-gray27 pw-gray" style="top:338px;left:68px;"> </div> <div id="el27_off" data-id="27" data-set="IkappaB70" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off27" style="top:338px;left:68px;"> </div> <div id="el27_ct" class="pw-tooltip" data-id="27"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ikb-alpha">IkB-alpha</a><br><a target="_blank" href="/target/ikb-beta">IkB-beta</a><br><a target="_blank" href="/target/ikb-epsilon">IkB-epsilon</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el28_gry" class="type_ii_ifn_signaling pw-label el-gray28 pw-gray" style="top:321px;left:19px;"> Proteasome </div> <div id="el28_off" data-id="28" data-set="Proteasome73" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off28" style="top:321px;left:19px;"> Proteasome</div> <div id="el28_ct" class="pw-tooltip" data-id="28"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/26s-proteasome">26S Proteasome</a><br><a target="_blank" href="/target/19s-proteasome">19S Proteasome</a><br><a target="_blank" href="/target/20s-proteasome">20S Proteasome</a><br><a target="_blank" href="/target/proteasome-inhibitors">proteasome inhibitors</a><br><a target="_blank" href="/target/proteasome-substrates">proteasome substrates</a><br> </div> </div> <div id="el29_gry" class="type_ii_ifn_signaling pw-sprite el-gray29 pw-gray" style="top:794px;left:59px;"> </div> <div id="el29_off" data-id="29" data-set="NF-kappaB74" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off29" style="top:794px;left:59px;"> </div> <div id="el29_ct" class="pw-tooltip" data-id="29"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/nfkb1">NFkB1</a><br><a target="_blank" href="/target/nfkb2">NFkB2</a><br><a target="_blank" href="/target/rela-nfkb-p65">RelA/NFkB p65</a><br><a target="_blank" href="/target/relb">RelB</a><br><a target="_blank" href="/target/c-rel">c-Rel</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el30_gry" class="type_ii_ifn_signaling pw-label el-gray30 pw-gray" style="top:789px;left:57px;"> NF-kappa B </div> <div id="el30_off" data-id="30" data-set="NF-kappaB74" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off30" style="top:789px;left:57px;"> NF-kappa B</div> <div id="el30_ct" class="pw-tooltip" data-id="30"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/nfkb1">NFkB1</a><br><a target="_blank" href="/target/nfkb2">NFkB2</a><br><a target="_blank" href="/target/rela-nfkb-p65">RelA/NFkB p65</a><br><a target="_blank" href="/target/relb">RelB</a><br><a target="_blank" href="/target/c-rel">c-Rel</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el31_gry" class="type_ii_ifn_signaling pw-label2 el-gray31 pw-gray" style="top:861px;left:60px;"> Survival Signals </div> <div id="el31_off" data-id="31" data-set="SurvivalSignals" data-type="" class="type_ii_ifn_signaling pw-label2 el-off31" style="top:861px;left:60px;"> Survival Signals</div> <div id="el31_ct" class="pw-tooltip" data-id="31"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el32_gry" class="type_ii_ifn_signaling pw-label2 pw-center el-gray32 pw-gray" style="top:875px;left:12px;"> Expression of Antigen<br>Processing/Presentation Signals </div> <div id="el32_off" data-id="32" data-set="SurvivalSignals" data-type="" class="type_ii_ifn_signaling pw-label2 pw-center el-off32" style="top:875px;left:12px;"> Expression of Antigen<br>Processing/Presentation Signals</div> <div id="el32_ct" class="pw-tooltip" data-id="32"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el33_gry" class="type_ii_ifn_signaling pw-sprite el-gray33 pw-gray" style="top:361px;left:194px;"> </div> <div id="el33_off" data-id="33" data-set="TSC1276" data-type="" class="type_ii_ifn_signaling pw-sprite el-off33" style="top:361px;left:194px;"> </div> <div id="el33_ct" class="pw-tooltip" data-id="33"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tsc1">TSC1</a><br><a target="_blank" href="/target/tsc2">TSC2</a><br> </div> </div> <div id="el34_gry" class="type_ii_ifn_signaling pw-label el-gray34 pw-gray" style="top:373px;left:207px;"> TSC1/2 </div> <div id="el34_off" data-id="34" data-set="TSC1276" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off34" style="top:373px;left:207px;"> TSC1/2</div> <div id="el34_ct" class="pw-tooltip" data-id="34"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tsc1">TSC1</a><br><a target="_blank" href="/target/tsc2">TSC2</a><br> </div> </div> <div id="el35_gry" class="type_ii_ifn_signaling pw-sprite el-gray35 pw-gray" style="top:411px;left:197px;"> </div> <div id="el35_off" data-id="35" data-set="mTOR77" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off35" style="top:411px;left:197px;"> </div> <div id="el35_ct" class="pw-tooltip" data-id="35"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tor">TOR</a><br> </div> </div> <div id="el36_gry" class="type_ii_ifn_signaling pw-label el-gray36 pw-gray" style="top:421px;left:198px;"> mTOR </div> <div id="el36_off" data-id="36" data-set="mTOR77" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off36" style="top:421px;left:198px;"> mTOR</div> <div id="el36_ct" class="pw-tooltip" data-id="36"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tor">TOR</a><br> </div> </div> <div id="el37_gry" class="type_ii_ifn_signaling pw-sprite el-gray37 pw-gray" style="top:463px;left:116px;"> </div> <div id="el37_off" data-id="37" data-set="FOUREBP178" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off37" style="top:463px;left:116px;"> </div> <div id="el37_ct" class="pw-tooltip" data-id="37"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/4ebp1">4EBP1</a><br> </div> </div> <div id="el38_gry" class="type_ii_ifn_signaling pw-label el-gray38 pw-gray" style="top:474px;left:82px;"> 4EBP1 </div> <div id="el38_off" data-id="38" data-set="FOUREBP178" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off38" style="top:474px;left:82px;"> 4EBP1</div> <div id="el38_ct" class="pw-tooltip" data-id="38"> 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<div id="el67_off" data-id="67" data-set="ERK1295" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off67" style="top:348px;left:579px;"> </div> <div id="el67_ct" class="pw-tooltip" data-id="67"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/erk1-erk2">ERK1/ERK2</a><br><a target="_blank" href="/target/erk1">ERK1</a><br><a target="_blank" href="/target/erk2">ERK2</a> </div> </div> <div id="el68_gry" class="type_ii_ifn_signaling pw-label el-gray68 pw-gray" style="top:357px;left:588px;"> ERK1/2 </div> <div id="el68_off" data-id="68" data-set="ERK1295" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off68" style="top:357px;left:588px;"> ERK1/2</div> <div id="el68_ct" class="pw-tooltip" data-id="68"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/erk1-erk2">ERK1/ERK2</a><br><a 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class="pw-tooltip" data-id="70"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/cebp-alpha">C/EBP alpha</a><br><a target="_blank" href="/target/cebp-epsilon">C/EBP epsilon</a> </div> </div> <div id="el71_gry" class="type_ii_ifn_signaling pw-sprite el-gray71 pw-gray" style="top:206px;left:593px;"> </div> <div id="el71_off" data-id="71" data-set="p3897" data-type="No Products Click" class="type_ii_ifn_signaling pw-sprite el-off71" style="top:206px;left:593px;"> </div> <div id="el71_ct" class="pw-tooltip" data-id="71"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/p38">p38</a><br><a target="_blank" href="/target/p38 alpha">p38 alpha</a><br><a target="_blank" href="/target/p38 beta">p38 beta</a><br><a target="_blank" href="/target/p38 gamma">p38 gamma</a><br><a target="_blank" href="/target/p38 delta">p38 delta</a><br><a target="_blank" href="/target/p38 Inhibitors">p38 Inhibitors</a><br> </div> </div> <div id="el72_gry" class="type_ii_ifn_signaling pw-label el-gray72 pw-gray" style="top:215px;left:600px;"> p38 </div> <div id="el72_off" data-id="72" data-set="p3897" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off72" style="top:215px;left:600px;"> p38</div> <div id="el72_ct" class="pw-tooltip" data-id="72"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/p38">p38</a><br><a target="_blank" href="/target/p38 alpha">p38 alpha</a><br><a target="_blank" href="/target/p38 beta">p38 beta</a><br><a target="_blank" href="/target/p38 gamma">p38 gamma</a><br><a target="_blank" href="/target/p38 delta">p38 delta</a><br><a target="_blank" href="/target/p38 Inhibitors">p38 Inhibitors</a><br> </div> </div> <div id="el73_gry" class="type_ii_ifn_signaling pw-label2 el-gray73 pw-gray" style="top:242px;left:607px;"> <h2 class="pw_txtBox" style="text-align:Center">Autophagy</h2> </div> <div id="el73_off" data-id="73" data-set="Autophagy" data-type="" class="type_ii_ifn_signaling pw-label2 el-off73" style="top:242px;left:607px;"> <h2 class="pw_txtBox" style="text-align:Center">Autophagy</h2></div> <div id="el73_ct" class="pw-tooltip" data-id="73"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el74_gry" class="type_ii_ifn_signaling pw-label2 el-gray74 pw-gray" style="top:709px;left:671px;"> Endoplasmic reticulum </div> <div id="el74_off" data-id="74" data-set="Endoplasmicreticulum" data-type="" class="type_ii_ifn_signaling pw-label2 el-off74" style="top:709px;left:671px;"> Endoplasmic reticulum</div> <div id="el74_ct" class="pw-tooltip" data-id="74"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el75_gry" class="type_ii_ifn_signaling pw-label2 pw-center el-gray75 pw-gray" style="top:653px;left:667px;"> <h2 class="pw_txtBox" style="text-align:Center">Proteolytic<br>Processing</h2> </div> <div id="el75_off" data-id="75" data-set="ProteolyticProcessing" data-type="" class="type_ii_ifn_signaling pw-label2 pw-center el-off75" style="top:653px;left:667px;"> <h2 class="pw_txtBox" style="text-align:Center">Proteolytic<br>Processing</h2></div> <div id="el75_ct" class="pw-tooltip" data-id="75"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el76_gry" class="type_ii_ifn_signaling pw-sprite el-gray76 pw-gray" style="top:666px;left:595px;"> </div> <div id="el76_off" data-id="76" data-set="ATF6101" data-type="" class="type_ii_ifn_signaling pw-sprite el-off76" style="top:666px;left:595px;"> </div> <div id="el76_ct" class="pw-tooltip" data-id="76"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products 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style="top:599px;left:628px;"> Golgi apparatus </div> <div id="el78_off" data-id="78" data-set="Golgiapparatus" data-type="" class="type_ii_ifn_signaling pw-label2 el-off78" style="top:599px;left:628px;"> Golgi apparatus</div> <div id="el78_ct" class="pw-tooltip" data-id="78"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el79_gry" class="type_ii_ifn_signaling pw-label el-gray79 pw-gray" style="top:791px;left:496px;"> ATF6 </div> <div id="el79_off" data-id="79" data-set="ATF6103" data-type="No Products Click" class="type_ii_ifn_signaling pw-label el-off79" style="top:791px;left:496px;"> ATF6</div> <div id="el79_ct" class="pw-tooltip" data-id="79"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=ATF6">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el80_gry" class="type_ii_ifn_signaling pw-label2 el-gray80 pw-gray" style="top:863px;left:424px;"> Additional Target Genes </div> <div id="el80_off" data-id="80" data-set="AdditionalTargetGenes" data-type="" class="type_ii_ifn_signaling pw-label2 el-off80" style="top:863px;left:424px;"> Additional Target Genes</div> <div id="el80_ct" class="pw-tooltip" data-id="80"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el81_gry" class="type_ii_ifn_signaling pw-label2 el-gray81 pw-gray" style="top:832px;left:287px;"> <h2 class="pw_txtBox" style="text-align:Center">GAS</h2> </div> <div id="el81_off" data-id="81" data-set="GAS" data-type="" class="type_ii_ifn_signaling pw-label2 el-off81" style="top:832px;left:287px;"> <h2 class="pw_txtBox" style="text-align:Center">GAS</h2></div> <div id="el81_ct" class="pw-tooltip" data-id="81"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> </div> <div id="pw-img"> <img id="cont-img" src="https://resources.rndsystems.com/images/Pathways/pathway-images/interferons_type_2_bg.png?t=12" alt="Type II Interferon Signaling Pathways" style="height:1022px"> </div> </div> <div id="pathway-description"><h2>Overview of Type II Interferon Signaling Pathways</h2><p><p>IFN-gamma is the only type II interferon. While it does not share structural homology or a common receptor with the type I IFNs, it too has antiviral and immunomodulatory properties. The biologically active form of IFN-gamma is a noncovalently-linked homodimer. This homodimer binds to the extracellular domain of two IFN-gamma R1/CD119 chains, which interact with IFN-gamma R2 to form the functional IFN-gamma receptor complex. The IFN-gamma R1 subunits of the receptor complex are associated with Jak1, while the IFN-gamma R2 subunits are associated with Jak2. Activation of Jak1 and Jak2 results in phosphorylation of the receptor and subsequent recruitment and phosphorylation of STAT1. STAT1 phosphorylation leads to its homodimerization and nuclear translocation. Once in the nucleus, STAT1 homodimers bind to IFN-gamma-activated sequence (GAS) elements in the promoters of target genes to regulate their transcription. Many of the target genes that are induced by IFN-gamma/STAT1 signaling are transcription factors that then drive the expression of secondary response genes. In addition, IFN-gamma signaling can activate MAPK, PI 3-K-Akt, and NF-kappa B signaling pathways to regulate the expression of a number of other genes. IFN-gamma signaling plays a key role in host defense by promoting macrophage activation, upregulating the expression of antigen processing and presentation molecules, driving the development and activation of Th1 cells, enhancing natural killer cell activity, regulating B cell functions, and inducing the production of chemokines that promote effector cell trafficking to sites of inflammation. While IFN-gamma has historically been known for its cytotoxic, cytostatic, and anti-tumor properties, multiple studies have also suggested that IFN-gamma may also have context-dependent proliferative and pro-tumorigenic effects. </p> <p>To learn more, please visit our <a href="/research-area/interferons">Interferons Research Area page</a></p></p></div> <div id="print-copy-form" class="accordion-wrapper"> <h3 class="builder-header builder-bead-type ui-accordion-header ui-helper-reset ui-state-default ui-corner-all ui-accordion-icons" data-toggle="collapse" data-target="#collapsePathwayRequest" aria-expanded="false" id="pathwayRequestAccordionHeader"> <span class="ui-accordion-header-icon" id="accordionArrow"></span> Get Print Copy of this Pathway </h3> <div class="collapse" id="collapsePathwayRequest"> <div id="pathwayRequestWebformWrapper"> <form class="webform-client-form webform-client-form-27981" action="/pathways/type-ii-interferon-signaling-pathways" method="post" id="webform-client-form-27981" accept-charset="UTF-8"><div><div class="form-item webform-component webform-component-textfield webform-component--first-name form-group form-item form-item-submitted-first-name form-type-textfield form-group"> <label class="control-label" for="edit-submitted-first-name">First Name <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-first-name" name="submitted[first_name]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--last-name form-group form-item form-item-submitted-last-name form-type-textfield form-group"> <label class="control-label" for="edit-submitted-last-name">Last Name <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-last-name" name="submitted[last_name]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-email webform-component--email-address form-group form-item form-item-submitted-email-address form-type-webform-email form-group"> <label class="control-label" for="edit-submitted-email-address">Email Address <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="email form-control form-text form-email required" type="email" id="edit-submitted-email-address" name="submitted[email_address]" size="60" /></div><div class="form-item webform-component webform-component-textfield webform-component--institution form-group form-item form-item-submitted-institution form-type-textfield form-group"> <label class="control-label" for="edit-submitted-institution">Institution <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-institution" name="submitted[institution]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--job-title form-group form-item form-item-submitted-job-title form-type-textfield form-group"> <label class="control-label" for="edit-submitted-job-title">Job Title</label> <input class="form-control form-text" type="text" id="edit-submitted-job-title" name="submitted[job_title]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--department form-group form-item form-item-submitted-department form-type-textfield form-group"> <label class="control-label" for="edit-submitted-department">Department</label> <input class="form-control form-text" type="text" id="edit-submitted-department" name="submitted[department]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--address-1 form-group form-item form-item-submitted-address-1 form-type-textfield form-group"> <label class="control-label" for="edit-submitted-address-1">Address 1 <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-address-1" name="submitted[address_1]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--address-2 form-group form-item form-item-submitted-address-2 form-type-textfield form-group"> <label class="control-label" for="edit-submitted-address-2">Address 2</label> <input class="form-control form-text" type="text" id="edit-submitted-address-2" name="submitted[address_2]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--city form-group form-item form-item-submitted-city form-type-textfield form-group"> <label class="control-label" for="edit-submitted-city">City <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-city" name="submitted[city]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-select webform-component--state form-group form-item form-item-submitted-state form-type-select form-group"> <label class="control-label" for="edit-submitted-state">State</label> <div class="select_wrapper"><select class="form-control form-select" id="edit-submitted-state" name="submitted[state]"><option value="" selected="selected">- None -</option><option value="AL">Alabama</option><option value="AK">Alaska</option><option value="AS">American Samoa</option><option value="AZ">Arizona</option><option value="AR">Arkansas</option><option value="CA">California</option><option value="CO">Colorado</option><option value="CT">Connecticut</option><option value="DE">Delaware</option><option value="DC">District of Columbia</option><option value="FL">Florida</option><option value="GA">Georgia</option><option value="GU">Guam</option><option value="HI">Hawaii</option><option value="ID">Idaho</option><option value="IL">Illinois</option><option value="IN">Indiana</option><option value="IA">Iowa</option><option value="KS">Kansas</option><option value="KY">Kentucky</option><option value="LA">Louisiana</option><option value="ME">Maine</option><option value="MH">Marshall Islands</option><option value="MD">Maryland</option><option value="MA">Massachusetts</option><option value="MI">Michigan</option><option value="MN">Minnesota</option><option value="MS">Mississippi</option><option value="MO">Missouri</option><option value="MT">Montana</option><option value="NE">Nebraska</option><option value="NV">Nevada</option><option value="NH">New Hampshire</option><option value="NJ">New Jersey</option><option value="NM">New Mexico</option><option value="NY">New York</option><option value="NC">North Carolina</option><option value="ND">North Dakota</option><option value="MP">Northern Marianas Islands</option><option value="OH">Ohio</option><option value="OK">Oklahoma</option><option value="OR">Oregon</option><option value="PW">Palau</option><option value="PA">Pennsylvania</option><option value="PR">Puerto Rico</option><option value="RI">Rhode Island</option><option value="SC">South Carolina</option><option value="SD">South Dakota</option><option value="TN">Tennessee</option><option value="TX">Texas</option><option value="UT">Utah</option><option value="VT">Vermont</option><option value="VI">Virgin Islands</option><option value="VA">Virginia</option><option value="WA">Washington</option><option value="WV">West Virginia</option><option value="WI">Wisconsin</option><option value="WY">Wyoming</option></select></div></div><div class="form-item webform-component webform-component-textfield webform-component--postal-code form-group form-item form-item-submitted-postal-code form-type-textfield form-group"> <label class="control-label" for="edit-submitted-postal-code">Postal Code <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-postal-code" name="submitted[postal_code]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-select webform-component--country form-group form-item form-item-submitted-country form-type-select form-group"> <label class="control-label" for="edit-submitted-country">Country</label> <div class="select_wrapper"><select class="form-control form-select" id="edit-submitted-country" name="submitted[country]"><option value="" selected="selected">- None -</option><option value="AL">Albania</option><option value="DZ">Algeria</option><option value="AD">Andorra</option><option value="AO">Angola</option><option value="AG">Antigua and Barbuda</option><option value="AR">Argentina</option><option value="AM">Armenia</option><option value="AW">Aruba</option><option value="AU">Australia</option><option value="AT">Austria</option><option value="AZ">Azerbaijan</option><option value="BS">Bahamas</option><option value="BH">Bahrain</option><option value="BD">Bangladesh</option><option value="BB">Barbados</option><option value="BE">Belgium</option><option value="BZ">Belize</option><option value="BJ">Benin</option><option value="BM">Bermuda</option><option value="BO">Bolivia</option><option value="BA">Bosnia and Herzegovina</option><option value="BW">Botswana</option><option value="BR">Brazil</option><option value="BN">Brunei</option><option value="BG">Bulgaria</option><option value="BF">Burkina Faso</option><option value="BI">Burundi</option><option value="KH">Cambodia</option><option value="CM">Cameroon</option><option value="CA">Canada</option><option value="KY">Cayman Islands</option><option value="CF">Central African Republic</option><option value="TD">Chad</option><option value="CL">Chile</option><option value="CN">China</option><option value="CO">Colombia</option><option value="CR">Costa Rica</option><option value="HR">Croatia</option><option value="CY">Cyprus</option><option value="CZ">Czech Republic</option><option value="DK">Denmark</option><option value="DJ">Djibouti</option><option value="DM">Dominica</option><option value="DO">Dominican Republic</option><option value="EC">Ecuador</option><option value="EG">Egypt</option><option value="SV">El Salvador</option><option value="GQ">Equatorial Guinea</option><option value="ER">Eritrea</option><option value="EE">Estonia</option><option value="ET">Ethiopia</option><option value="FK">Falkland Islands</option><option value="FJ">Fiji</option><option value="FI">Finland</option><option value="FR">France</option><option value="PF">French Polynesia</option><option value="GA">Gabon</option><option value="GM">Gambia</option><option value="GE">Georgia</option><option value="DE">Germany</option><option value="GH">Ghana</option><option value="GI">Gibraltar</option><option value="GR">Greece</option><option value="GD">Grenada</option><option value="GP">Guadeloupe</option><option value="GU">Guam</option><option value="GT">Guatemala</option><option value="GN">Guinea</option><option value="GW">Guinea-Bissau</option><option value="GY">Guyana</option><option value="HT">Haiti</option><option value="HN">Honduras</option><option value="HK">Hong Kong S.A.R., China</option><option value="HU">Hungary</option><option value="IS">Iceland</option><option value="IN">India</option><option value="ID">Indonesia</option><option value="IQ">Iraq</option><option value="IE">Ireland</option><option value="IL">Israel</option><option value="IT">Italy</option><option value="CI">Ivory Coast</option><option value="JM">Jamaica</option><option value="JP">Japan</option><option value="JO">Jordan</option><option value="KZ">Kazakhstan</option><option value="KE">Kenya</option><option value="KW">Kuwait</option><option value="KG">Kyrgyzstan</option><option value="LV">Latvia</option><option value="LB">Lebanon</option><option value="LS">Lesotho</option><option value="LR">Liberia</option><option value="LI">Liechtenstein</option><option value="LT">Lithuania</option><option value="LU">Luxembourg</option><option value="MK">Macedonia</option><option value="MG">Madagascar</option><option value="MW">Malawi</option><option value="MY">Malaysia</option><option value="ML">Mali</option><option value="MT">Malta</option><option value="MH">Marshall Islands</option><option value="MR">Mauritania</option><option value="MX">Mexico</option><option value="MD">Moldova</option><option value="MC">Monaco</option><option value="MN">Mongolia</option><option 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Type II Interferon Signaling Pathways