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(PDF) A fully liquid diphtheria–tetanus–five component acellular pertussis–inactivated poliomyelitis–Haemophilus influenzae type b conjugate vaccine: immunogenicity and safety of primary vaccination in Taiwanese infants | Luan-yin Chang - Academia.edu
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window.loswp.work = {"work":{"id":14115044,"created_at":"2015-07-16T07:33:56.301-07:00","from_world_paper_id":139609051,"updated_at":"2024-11-13T05:30:06.273-08:00","_data":{"grobid_abstract":"Objective: To evaluate antibody persistence one year after three-dose primary vaccination and booster immune response during the second year of life for a fully liquid diphtheria-tetanusacellular pertussis-inactivated poliomyelitis-Haemophilus influenzae type b (DTaP-IPV-PRPT) vaccine. Methods: Infants at 18-19 months of age were given a booster dose of either DTaP-IPV-PRPT (group A) or DTaP-IPV plus PRPT at separate injection sites (group B), after primary vaccination at two, four and six months of age, with the same vaccines. Antibody concentrations were measured pre-and post-booster. Reactogenicity and safety were evaluated from parent reports. Results: Before the booster dose, 93.1% of group A and 95.1% of group B children still had anti-PRP antibody titers 0.15 mg/ml. All children had antibody levels believed to protect against tetanus, polio 1 (except one subject in group B), polio 2, polio 3, and diphtheria (except one subject in group A). At least 94% of children still had antibody concentrations 5 ELISA units (EU) to pertussis antigens (pertussis toxoid (PT), filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae 2 and 3 (FIM2+3)). One month after the booster dose, all subjects achieved antibody concentrations or titers believed to be protective for PRP (polyribose ribitol phosphate)(1 mg/ml), diphtheria and tetanus (0.1 IU/ml) and poliovirus types 1, 2, and 3","publication_date":"2007,,","publication_name":"International Journal of Infectious Diseases","grobid_abstract_attachment_id":"44589502"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"A fully liquid diphtheria–tetanus–five component acellular pertussis–inactivated poliomyelitis–Haemophilus influenzae type b conjugate vaccine: immunogenicity and safety of primary vaccination in Taiwanese infants","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [33115704]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; 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data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="97901018" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/97901018/One_year_post_primary_antibody_persistence_and_booster_immune_response_to_a_fully_liquid_five_component_acellular_pertussis_diphtheria_tetanus_inactivated_poliomyelitis_Haemophilus_influenzae_type_b_conjugate_vaccine">One-year post-primary antibody persistence and booster immune response to a fully liquid five-component acellular pertussis, diphtheria, tetanus, inactivated poliomyelitis, Haemophilus influenzae type b conjugate vaccine</a><div class="ds-related-work--metadata"><a 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href="https://www.academia.edu/28474211/Antibody_persistence_against_diphtheria_tetanus_pertussis_poliomyelitis_and_Haemophilus_influenzae_type_b_Hib_in_5_6_year_old_children_after_primary_vaccination_and_first_booster_with_a_pentavalent_combined_acellular_pertussis_vaccine_immunogenicity_and_tolerance_of_a_tetravalent_combined_a_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="18549004" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18549004/Safety_and_immunogenicity_of_a_combined_five_component_pertussis_diphtheria_tetanus_inactivated_poliomyelitis_Haemophilus_b_conjugate_vaccine_administered_to_infants_at_two_four_and_six_months_of_age">Safety and immunogenicity of a combined five-component pertussis-diphtheria-tetanus-inactivated poliomyelitis-Haemophilus b conjugate vaccine administered to infants at two, four and six months of age</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="60261763" href="https://independent.academia.edu/JohnThipphawong">John Thipphawong</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38584614" href="https://nrc-ca.academia.edu/LuisBarreto">Luis Barreto</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1998</p><p class="ds-related-work--abstract ds2-5-body-sm">Safety, immunogenicity and lot consistency of five-component pertussis combination vaccine (CPDT-IPV//PRP-T) in infants were compared to that of whole cell pertussis combination vaccine (DPT-IPV//PRP-T), as were separate and combined injections of CPDT-IPV and PRP-T. No significant differences in adverse event rates were observed between lots of CPDT-IPV//PRP-T or between separate or combined injections of CPDT-IPV and PRP-T. Minor differences in antibody responses were observed between lots of component pertussis vaccine. Higher concentrations of diphtheria and tetanus antitoxins were induced by separate than by combined injection of CPDT-IPV and PRP-T, but no other differences in immunogenicity were observed. Adverse reactions were more than twice as frequent after whole cell than after component pertussis vaccines. Antibody responses to pertussis toxoid, filamentous hemagglutin and pertactin were significantly greater after component vaccines, while the response to type 3 poliovirus was higher after whole cell vaccine. No significant differences were observed for other vaccine components. CPDT-IPV//PRP-T was safe and immunogenic in infants. Antibody results were similar to those observed in a Swedish field trial that demonstrated CPDT to be 85% effective in preventing clinical pertussis.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety and immunogenicity of a combined five-component pertussis-diphtheria-tetanus-inactivated poliomyelitis-Haemophilus b conjugate vaccine administered to infants at two, four and six months of age","attachmentId":42159872,"attachmentType":"pdf","work_url":"https://www.academia.edu/18549004/Safety_and_immunogenicity_of_a_combined_five_component_pertussis_diphtheria_tetanus_inactivated_poliomyelitis_Haemophilus_b_conjugate_vaccine_administered_to_infants_at_two_four_and_six_months_of_age","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/18549004/Safety_and_immunogenicity_of_a_combined_five_component_pertussis_diphtheria_tetanus_inactivated_poliomyelitis_Haemophilus_b_conjugate_vaccine_administered_to_infants_at_two_four_and_six_months_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="14115018" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" 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class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="96424509" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/96424509/Reactogenicity_and_immunogenicity_of_reduced_antigen_content_diphtheria_tetanus_acellular_pertussis_vaccines_as_a_booster_in_4_7_year_old_children_primed_with_diphtheria_tetanus_whole_cell_pertussis_vaccine_before_2_years_of_age">Reactogenicity and immunogenicity of reduced antigen content diphtheria–tetanus–acellular pertussis vaccines as a booster in 4–7-year-old children primed with diphtheria–tetanus–whole cell pertussis vaccine before 2 years of age</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="116297980" href="https://independent.academia.edu/KarimIgbaria">Karim Igbaria</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reactogenicity and immunogenicity of reduced antigen content diphtheria–tetanus–acellular pertussis vaccines as a booster in 4–7-year-old children primed with diphtheria–tetanus–whole cell pertussis vaccine before 2 years of age","attachmentId":98326295,"attachmentType":"pdf","work_url":"https://www.academia.edu/96424509/Reactogenicity_and_immunogenicity_of_reduced_antigen_content_diphtheria_tetanus_acellular_pertussis_vaccines_as_a_booster_in_4_7_year_old_children_primed_with_diphtheria_tetanus_whole_cell_pertussis_vaccine_before_2_years_of_age","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/96424509/Reactogenicity_and_immunogenicity_of_reduced_antigen_content_diphtheria_tetanus_acellular_pertussis_vaccines_as_a_booster_in_4_7_year_old_children_primed_with_diphtheria_tetanus_whole_cell_pertussis_vaccine_before_2_years_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="25080284" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/25080284/Reactogenicity_and_immunogenicity_of_a_booster_dose_of_a_combined_diphtheria_tetanus_and_tricomponent_acellular_pertussis_vaccine_at_fourteen_to_twenty_eight_months_of_age">Reactogenicity and immunogenicity of a booster dose of a combined diphtheria, tetanus, and tricomponent acellular pertussis vaccine at fourteen to twenty-eight months of age</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="48238879" href="https://independent.academia.edu/ClemensRalf">Ralf Clemens</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Pediatrics, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reactogenicity and immunogenicity of a booster dose of a combined diphtheria, tetanus, and tricomponent acellular pertussis vaccine at fourteen to twenty-eight months of age","attachmentId":45402368,"attachmentType":"pdf","work_url":"https://www.academia.edu/25080284/Reactogenicity_and_immunogenicity_of_a_booster_dose_of_a_combined_diphtheria_tetanus_and_tricomponent_acellular_pertussis_vaccine_at_fourteen_to_twenty_eight_months_of_age","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/25080284/Reactogenicity_and_immunogenicity_of_a_booster_dose_of_a_combined_diphtheria_tetanus_and_tricomponent_acellular_pertussis_vaccine_at_fourteen_to_twenty_eight_months_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="95262307" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/95262307/Safety_and_Immunogenicity_of_a_Fully_Liquid_Vaccine_Containing_Five_Component_Pertussis_Diphtheria_Tetanus_Inactivated_Poliomyelitis_Haemophilus_influenzaeType_B_Conjugate_Vaccines_Administered_at_Two_Four_Six_and_18_Months_of_Age">Safety and Immunogenicity of a Fully Liquid Vaccine Containing Five-Component Pertussis-Diphtheria-Tetanus-Inactivated Poliomyelitis-Haemophilus influenzaeType B Conjugate Vaccines Administered at Two, Four, Six and 18 Months of Age</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38584614" href="https://nrc-ca.academia.edu/LuisBarreto">Luis Barreto</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Canadian Journal of Infectious Diseases and Medical Microbiology, 2007</p><p class="ds-related-work--abstract ds2-5-body-sm">OBJECTIVE: The safety, immunogenicity and lot consistency of a fully liquid, five-component acellular pertussis combination vaccine, comprised of diphteria, tetanus and acellular pertussis, inactivated polio vaccine,Haemophilus influenzaetype b (DTaP-IPV-Hib [Pediacel, sanofi pasteur, Canada]) were assessed and compared with that of Hib vaccine reconstituted with the five-component acellular pertussis combination vaccine (DTaP-IPV//Hib, Pentacel [sanofi pasteur, Canada]).METHODS: Infants were recruited at vaccine study centres in Montreal, Quebec; Simon Fraser Health Region, British Columbia, and southern Alberta after the protocol had been approved by the relevant institutional ethics committees. Written informed consent was obtained from the parents or guardians of all subjects. At two months of age, the infants were randomly assigned to receive one of three consecutive production lots of DTaP-IPV-Hib by intramuscular injection. Reactions to vaccinations were assessed by parental ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety and Immunogenicity of a Fully Liquid Vaccine Containing Five-Component Pertussis-Diphtheria-Tetanus-Inactivated Poliomyelitis-Haemophilus influenzaeType B Conjugate Vaccines Administered at Two, Four, Six and 18 Months of Age","attachmentId":97492000,"attachmentType":"pdf","work_url":"https://www.academia.edu/95262307/Safety_and_Immunogenicity_of_a_Fully_Liquid_Vaccine_Containing_Five_Component_Pertussis_Diphtheria_Tetanus_Inactivated_Poliomyelitis_Haemophilus_influenzaeType_B_Conjugate_Vaccines_Administered_at_Two_Four_Six_and_18_Months_of_Age","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/95262307/Safety_and_Immunogenicity_of_a_Fully_Liquid_Vaccine_Containing_Five_Component_Pertussis_Diphtheria_Tetanus_Inactivated_Poliomyelitis_Haemophilus_influenzaeType_B_Conjugate_Vaccines_Administered_at_Two_Four_Six_and_18_Months_of_Age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="12526756" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12526756/Reactogenicity_and_Immunogenicity_at_Preschool_Age_of_a_Booster_Dose_of_Two_Three_Component_Diphtheria_Tetanus_Acellular_Pertussis_Vaccines_in_Children_Primed_in_Infancy_With_Acellular_Vaccines">Reactogenicity and Immunogenicity at Preschool Age of a Booster Dose of Two Three-Component Diphtheria-Tetanus-Acellular Pertussis Vaccines in Children Primed in Infancy With Acellular Vaccines</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31415591" href="https://ospedalebambinogesu.academia.edu/AlbertoTozzi">Alberto Tozzi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">PEDIATRICS, 2001</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reactogenicity and Immunogenicity at Preschool Age of a Booster Dose of Two Three-Component Diphtheria-Tetanus-Acellular Pertussis Vaccines in Children Primed in Infancy With Acellular Vaccines","attachmentId":46114716,"attachmentType":"pdf","work_url":"https://www.academia.edu/12526756/Reactogenicity_and_Immunogenicity_at_Preschool_Age_of_a_Booster_Dose_of_Two_Three_Component_Diphtheria_Tetanus_Acellular_Pertussis_Vaccines_in_Children_Primed_in_Infancy_With_Acellular_Vaccines","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/12526756/Reactogenicity_and_Immunogenicity_at_Preschool_Age_of_a_Booster_Dose_of_Two_Three_Component_Diphtheria_Tetanus_Acellular_Pertussis_Vaccines_in_Children_Primed_in_Infancy_With_Acellular_Vaccines"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="55448106" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/55448106/Comparative_immunogenicity_and_safety_of_different_multivalent_component_pertussis_vaccine_formulations_and_a_5_component_acellular_pertussis_vaccine_in_infants_and_toddlers_A_randomized_controlled_open_label_multicenter_study">Comparative immunogenicity and safety of different multivalent component pertussis vaccine formulations and a 5-component acellular pertussis vaccine in infants and toddlers: A randomized, controlled, open-label, multicenter study</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="79011677" href="https://independent.academia.edu/FernandoNoriega16">Fernando Noriega</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Comparative immunogenicity and safety of different multivalent component pertussis vaccine formulations and a 5-component acellular pertussis vaccine in infants and toddlers: A randomized, controlled, open-label, multicenter study","attachmentId":71312719,"attachmentType":"pdf","work_url":"https://www.academia.edu/55448106/Comparative_immunogenicity_and_safety_of_different_multivalent_component_pertussis_vaccine_formulations_and_a_5_component_acellular_pertussis_vaccine_in_infants_and_toddlers_A_randomized_controlled_open_label_multicenter_study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/55448106/Comparative_immunogenicity_and_safety_of_different_multivalent_component_pertussis_vaccine_formulations_and_a_5_component_acellular_pertussis_vaccine_in_infants_and_toddlers_A_randomized_controlled_open_label_multicenter_study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="26688399" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26688399/Immunogenicity_and_reactogenicity_of_two_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_virus_Haemophilus_influenzae_type_b_vaccines_administered_at_3_5_and_11_12_months_of_age">Immunogenicity and reactogenicity of two diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio virus- Haemophilus influenzae type b vaccines administered at 3, 5 and 11–12 months of age</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50682354" href="https://independent.academia.edu/MahmoodJedditehrani">Mahmood Jeddi-tehrani</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Human Vaccines, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and reactogenicity of two diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio virus- Haemophilus influenzae type b vaccines administered at 3, 5 and 11–12 months of age","attachmentId":46970339,"attachmentType":"pdf","work_url":"https://www.academia.edu/26688399/Immunogenicity_and_reactogenicity_of_two_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_virus_Haemophilus_influenzae_type_b_vaccines_administered_at_3_5_and_11_12_months_of_age","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/26688399/Immunogenicity_and_reactogenicity_of_two_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_virus_Haemophilus_influenzae_type_b_vaccines_administered_at_3_5_and_11_12_months_of_age"><span 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You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="32458533" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/32458533/Effect_of_priming_with_diphtheria_and_tetanus_toxoids_combined_with_whole_cell_pertussis_vaccine_or_with_acellular_pertussis_vaccine_on_the_safety_and_immunogenicity_of_a_booster_dose_of_an_acellular_pertussis_vaccine_containing_a_genetically_inactivated_pertussis_toxin_in_fifteen_to_twenty_one_">Effect of priming with diphtheria and tetanus toxoids combined with whole-cell pertussis vaccine or with acellular pertussis vaccine on the safety and immunogenicity of a booster 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href="https://www.academia.edu/31902966/Immunogenicity_and_safety_of_a_pentavalent_acellular_pertussis_combined_vaccine_including_diphtheria_tetanus_inactivated_poliovirus_and_conjugated_Haemophilus_Influenzae_type_b_polysaccharide_for_primary_vaccination_at_2_3_4_or_3_4_5_months_of_age_in_infants_in_China_">Immunogenicity and safety of a pentavalent acellular pertussis combined vaccine including diphtheria, tetanus, inactivated poliovirus and conjugated Haemophilus Influenzae type b polysaccharide for primary vaccination at 2, 3, 4 or 3, 4, 5 months of age in infants in China☆☆☆</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50708429" href="https://independent.academia.edu/YanZhang106">Yan Zhang</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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pertussis booster vaccines in children: Standard pediatric versus a reduced-antigen content formulation</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37298606" href="https://unimedizin-mainz.academia.edu/ClaudiusMeyer">Claudius Meyer</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Human Vaccines, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and reactogenicity of acellular pertussis booster vaccines in children: Standard pediatric versus a reduced-antigen content 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data-entity-id="64478383" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/64478383/Immunogenicity_and_safety_of_a_low_dose_diphtheria_tetanus_and_acellular_pertussis_combination_vaccine_with_either_inactivated_or_oral_polio_vaccine_as_a_pre_school_">Immunogenicity and safety of a low-dose diphtheria, tetanus and acellular pertussis combination vaccine with either inactivated or oral polio vaccine as a pre-school …</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="28594054" href="https://independent.academia.edu/TraceyChantler">Tracey Chantler</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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at 3, 5 and 10 Years Postvaccination in 11-14 Year-Old Adolescents Randomized to Booster Immunization with a Combined Tetanus, Diphtheria, 5-Component Acellular Pertussis, and Inactivated Poliomyelitis Vaccine (Tdap-IPV; Adacel-Polio®) Administered...</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37081544" href="https://independent.academia.edu/JoanneEmbree">Joanne Embree</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical and vaccine immunology : CVI, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity, Safety, and Antibody Persistence at 3, 5 and 10 Years Postvaccination in 11-14 Year-Old Adolescents Randomized to Booster Immunization with a Combined Tetanus, Diphtheria, 5-Component Acellular Pertussis, and Inactivated 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href="https://www.academia.edu/17355908/Immunogenicity_Safety_and_Antibody_Persistence_at_3_5_and_10_Years_Postvaccination_in_11_14_Year_Old_Adolescents_Randomized_to_Booster_Immunization_with_a_Combined_Tetanus_Diphtheria_5_Component_Acellular_Pertussis_and_Inactivated_Poliomyelitis_Vaccine_Tdap_IPV_Adacel_Polio_Administered_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="17279354" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17279354/Booster_vaccination_of_pre_school_children_with_reduced_antigen_content_diphtheria_tetanus_acellular_pertussis_inactivated_poliovirus_vaccine_co_administered_with_measles_mumps_rubella_varicella_vaccine">Booster 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href="https://www.academia.edu/17279354/Booster_vaccination_of_pre_school_children_with_reduced_antigen_content_diphtheria_tetanus_acellular_pertussis_inactivated_poliovirus_vaccine_co_administered_with_measles_mumps_rubella_varicella_vaccine"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="12474684" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12474684/Booster_vaccination_of_toddlers_with_reduced_antigen_content_diphtheria_tetanus_acellular_pertussis_vaccine">Booster vaccination of toddlers with reduced antigen content diphtheria–tetanus–acellular pertussis vaccine</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author 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href="https://www.academia.edu/9070602/Reactogenicity_and_immunogenicity_of_reduced_antigen_content_diphtheria_tetanus_acellular_pertussis_vaccine_dTpa_administered_as_a_booster_to_4_6_year_old_children_primed_with_four_doses_of_whole_cell_pertussis_vaccine">Reactogenicity and immunogenicity of reduced antigen content diphtheria–tetanus–acellular pertussis vaccine (dTpa) administered as a booster to 4–6 year-old children primed with four doses of whole-cell pertussis vaccine</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="20575384" href="https://unrika.academia.edu/HansHutagalung">Hans Hutagalung</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reactogenicity and immunogenicity of 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href="https://www.academia.edu/9070602/Reactogenicity_and_immunogenicity_of_reduced_antigen_content_diphtheria_tetanus_acellular_pertussis_vaccine_dTpa_administered_as_a_booster_to_4_6_year_old_children_primed_with_four_doses_of_whole_cell_pertussis_vaccine"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="8" data-entity-id="64478399" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/64478399/Immunogenicity_and_safety_of_a_low_dose_diphtheria_tetanus_and_acellular_pertussis_combination_vaccine_with_either_inactivated_or_oral_polio_vaccine_as_a_pre_school_booster_in_UK_children">Immunogenicity and safety of a low-dose diphtheria, tetanus and acellular pertussis combination vaccine with either inactivated or oral polio vaccine as a pre-school booster in UK children</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="28594054" href="https://independent.academia.edu/TraceyChantler">Tracey Chantler</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and safety of a low-dose diphtheria, tetanus and acellular pertussis combination vaccine with either inactivated or oral polio vaccine as a pre-school booster in UK 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href="https://www.academia.edu/48454830/A_randomized_dose_ranging_assessment_of_the_immunogenicity_and_safety_of_a_booster_dose_of_a_combined_diphtheria_tetanus_whole_cell_pertussis_hepatitis_B_inactivated_poliovirus_Hemophilus_influenzae_type_b_DTPw_HBV_IPV_Hib_vaccine_vs_co_administration_of_DTPw_HBV_Hib_and_IPV_vaccines_in_12_t_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="10" data-entity-id="28794199" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" 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ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/23754396/Anti_pertussis_antibody_kinetics_following_DTaP_IPV_booster_vaccination_in_Norwegian_children_7_8_years_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="12" data-entity-id="24293897" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24293897/Safety_and_immunogenicity_of_combined_diphtheria_tetanus_pertussis_whole_cell_and_acellular_Haemophilus_influenzae_b_conjugate_vaccines_administered_to_Indonesian_children">Safety and immunogenicity of combined diphtheria?tetanus?pertussis (whole cell and acellular)?Haemophilus influenzae-b conjugate vaccines administered to 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data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and Reactogenicity of Diphtheria—Tetanus—Acellular Pertussis—Hepatitis B—Inactivated Poliovirus and Haemophilus influenzae Type B Vaccines Administered Concomitantly to Infants as a Three-dose Primary Course","attachmentId":49599593,"attachmentType":"pdf","work_url":"https://www.academia.edu/29154874/Immunogenicity_and_Reactogenicity_of_Diphtheria_Tetanus_Acellular_Pertussis_Hepatitis_B_Inactivated_Poliovirus_and_Haemophilus_influenzae_Type_B_Vaccines_Administered_Concomitantly_to_Infants_as_a_Three_dose_Primary_Course","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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DTaP-IPV Induces High Levels of Pertussis Antibodies with a Significant Increase in Opsonophagocytic Activity</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="41728573" href="https://independent.academia.edu/THerstad">T. Herstad</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical and Vaccine Immunology, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunization of Teenagers with a Fifth Dose of Reduced DTaP-IPV Induces High Levels of Pertussis Antibodies with a Significant Increase in Opsonophagocytic Activity","attachmentId":72181323,"attachmentType":"pdf","work_url":"https://www.academia.edu/57137837/Immunization_of_Teenagers_with_a_Fifth_Dose_of_Reduced_DTaP_IPV_Induces_High_Levels_of_Pertussis_Antibodies_with_a_Significant_Increase_in_Opsonophagocytic_Activity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/57137837/Immunization_of_Teenagers_with_a_Fifth_Dose_of_Reduced_DTaP_IPV_Induces_High_Levels_of_Pertussis_Antibodies_with_a_Significant_Increase_in_Opsonophagocytic_Activity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related topics</h2><div class="ds-research-interests--pills-container"><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="159" href="https://www.academia.edu/Documents/in/Microbiology">Microbiology</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="6947" href="https://www.academia.edu/Documents/in/Medical_Microbiology">Medical Microbiology</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="17960" href="https://www.academia.edu/Documents/in/Infectious_Diseases">Infectious Diseases</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="94451" href="https://www.academia.edu/Documents/in/Taiwan">Taiwan</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="98925" href="https://www.academia.edu/Documents/in/Female">Female</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="111545" href="https://www.academia.edu/Documents/in/Male">Male</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="134346" href="https://www.academia.edu/Documents/in/Infant">Infant</a></div></div></div></div></div><div class="footer--content"><ul class="footer--main-links hide-on-mobile"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/hiring"><svg style="width: 13px; 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