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class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">18</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">17</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;">I am full professor of biomaterial science and tissue engineering<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="suggested-academics-container"><div 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type="text/css">.suggested-academics--header h3{font-size:16px;font-weight:500;line-height:20px}</style><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Saeed Karbasi</h3></div><div class="js-work-strip profile--work_container" data-work-id="34032129"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/34032129/Evaluation_of_Hydrostatic_Pressure_on_Metabolism_of_the_Articular_Chondrocytes_Seeded_on_Biodegradable_Polyurethane_as_Tissue_Engineering_Scaffold"><img alt="Research paper thumbnail of Evaluation of Hydrostatic Pressure on Metabolism of the Articular Chondrocytes Seeded on Biodegradable Polyurethane as Tissue Engineering Scaffold" class="work-thumbnail" src="https://attachments.academia-assets.com/53973274/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/34032129/Evaluation_of_Hydrostatic_Pressure_on_Metabolism_of_the_Articular_Chondrocytes_Seeded_on_Biodegradable_Polyurethane_as_Tissue_Engineering_Scaffold">Evaluation of Hydrostatic Pressure on Metabolism of the Articular Chondrocytes Seeded on Biodegradable Polyurethane as Tissue Engineering Scaffold</a></div><div class="wp-workCard_item"><span>Ifmbe Proceedings</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">One of the most effective parameters in articular cartilage tissue engineering is cell stimulatio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">One of the most effective parameters in articular cartilage tissue engineering is cell stimulation and growth. Using a reaction system which incorporates many of the same conditions as an articulating joint such as intermittent loading, long term culture and a suitable 3-D growth environment could stimulate chondrocytes metabolism. It has demonstrated that hydrostatic pressure, as a physicochemical parameter, also could increase chondrocytes metabolism in tissue constructs. In this research, the effect of hydrostatic pressure was investigated on lactate production and GAG (glycosaminoglycane) content produced by chondrocytes. The isolated chondrocytes, from animal joint, were seeded on a biodegradable polyesterurethane scaffold (BPUS) namely Degrapol 庐 and 4 MPa was applied to the samples for 4 h per day as a cyclic (1HZ, Sinusoidal) load. The results showed that in constant physicochemical conditions, the hydrostatic pressure could increase the amount of lactate, rate of lactate production and GAG as a significant cartilage metabolism on BPUS. In comparison to other biodegradable polymers, this research was showed that BPUS has great potential for articular cartilage tissue engineering, in vitro.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5a54675b1c8579ac8c8a68d909a68a8c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53973274,"asset_id":34032129,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53973274/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032129"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032129"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032129; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032129]").text(description); $(".js-view-count[data-work-id=34032129]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032129; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032129']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5a54675b1c8579ac8c8a68d909a68a8c" } } $('.js-work-strip[data-work-id=34032129]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032129,"title":"Evaluation of Hydrostatic Pressure on Metabolism of the Articular Chondrocytes Seeded on Biodegradable Polyurethane as Tissue Engineering Scaffold","translated_title":"","metadata":{"grobid_abstract":"One of the most effective parameters in articular cartilage tissue engineering is cell stimulation and growth. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032127-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032126"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/34032126/Evaluation_of_structural_and_mechanical_properties_of_electrospun_nano_micro_hybrid_of_poly_hydroxybutyrate_chitosan_silk_scaffold_for_cartilage_tissue_engineering"><img alt="Research paper thumbnail of Evaluation of structural and mechanical properties of electrospun nano-micro hybrid of poly hydroxybutyrate-chitosan/silk scaffold for cartilage tissue engineering" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Evaluation of structural and mechanical properties of electrospun nano-micro hybrid of poly hydroxybutyrate-chitosan/silk scaffold for cartilage tissue engineering</div><div class="wp-workCard_item"><span>Advanced Biomedical Research</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">One of the new methods of scaffold fabrication is a nano-micro hybrid structure in which the prop...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">One of the new methods of scaffold fabrication is a nano-micro hybrid structure in which the properties of the scaffold are improved by introducing nanometer and micrometer structures. This method could be suitable for scaffold designing if some features improve. In this study, electrospun nanofibers of 9% weight solution of poly (3-hydroxybutyrate) (P3HB) and a 15% weight of chitosan by trifluoroacetic acid were coated on both the surface of a silk knitted substrate in the optimum condition to improve the mechanical properties of scaffolds for cartilage tissue engineering application. These hybrid nano-micro fibrous scaffolds were characterized by structural and mechanical evaluation methods. Scanning electron microscopy values and porosity analysis showed that average diameter of nanofibers was 584.94 nm in electrospinning part and general porosity was more than 80%. Fourier transform infrared spectroscopy results indicated the presence of all elements without pollution. The tensile test also stated that by electrospinning, as well as adding chitosan, both maximum strength and maximum elongation increased to 187 N and 10 mm. It means that the microfibrous part of scaffold could affect mechanical properties of nano part of the hybrid scaffold, significantly. It could be concluded that P3HB-chitosan/silk hybrid scaffolds can be a good candidate for cartilage tissue engineering.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032126"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032126"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032126; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032126]").text(description); $(".js-view-count[data-work-id=34032126]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032126; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032126']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=34032126]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032126,"title":"Evaluation of structural and mechanical properties of electrospun nano-micro hybrid of poly hydroxybutyrate-chitosan/silk scaffold for cartilage tissue engineering","translated_title":"","metadata":{"abstract":"One of the new methods of scaffold fabrication is a nano-micro hybrid structure in which the properties of the scaffold are improved by introducing nanometer and micrometer structures. This method could be suitable for scaffold designing if some features improve. In this study, electrospun nanofibers of 9% weight solution of poly (3-hydroxybutyrate) (P3HB) and a 15% weight of chitosan by trifluoroacetic acid were coated on both the surface of a silk knitted substrate in the optimum condition to improve the mechanical properties of scaffolds for cartilage tissue engineering application. These hybrid nano-micro fibrous scaffolds were characterized by structural and mechanical evaluation methods. Scanning electron microscopy values and porosity analysis showed that average diameter of nanofibers was 584.94 nm in electrospinning part and general porosity was more than 80%. Fourier transform infrared spectroscopy results indicated the presence of all elements without pollution. The tensile test also stated that by electrospinning, as well as adding chitosan, both maximum strength and maximum elongation increased to 187 N and 10 mm. 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These hybrid nano-micro fibrous scaffolds were characterized by structural and mechanical evaluation methods. Scanning electron microscopy values and porosity analysis showed that average diameter of nanofibers was 584.94 nm in electrospinning part and general porosity was more than 80%. Fourier transform infrared spectroscopy results indicated the presence of all elements without pollution. The tensile test also stated that by electrospinning, as well as adding chitosan, both maximum strength and maximum elongation increased to 187 N and 10 mm. It means that the microfibrous part of scaffold could affect mechanical properties of nano part of the hybrid scaffold, significantly. 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In this paper, hydroxyapatite (HA) powder was made out of bovine bone by thermal analysis at 900掳C and first, and then, porous HA (50 weight percentage) was produced by polyurethane sponge replication method. In order to improve the scaffold mechanical properties, they have been coated with poly hydroxybutyrate. In terms of phase studies, morphology, and specifying agent groups, the specific characterization devices such as X-ray diffraction and Fourier transform infrared, were employed. To compare the behavior of cellular scaffolds, they were divided into four groups of scaffolds. The osteoblast cells were cultured. To perform phase studies, analysis of Methylthiazole tetrazolium (MTT) and Trypan blue were carried out for the viability and attachment on the surface of the scaffold, and the specification of Scanning electron microscopy was employed for the morphology of the cells. The results of MTT analysis performed on four groups of scaffolds have shown that Titanium oxide (Tio2) had no effect on cell growth alone and HA was the main factor of growth and cell osteoblast adhesion on the scaffold. Moreover, the results showed that the use of coating with poly-3-hydroxybutyrate saved the factors and placed the osteoblasts within the pore. Since the main part of bone consists of HA, the TiO2 accelerates the formation of apatite crystals at the scaffold surface which is the evidence for bone tissue regeneration. It is likely that the relation between HA and TiO2 leads to an increase in osteoblast adhesion and growth of cells on the scaffold surface.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032125"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032125"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032125; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032125]").text(description); $(".js-view-count[data-work-id=34032125]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032125; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032125']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=34032125]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032125,"title":"Evaluate the growth and adhesion of osteoblast cells on nanocomposite scaffold of hydroxyapatite/titania coated with poly hydroxybutyrate","translated_title":"","metadata":{"abstract":"The generation of bioartificial bone tissues may help to overcome the problems related to donor site morbidity and size limitations. In this paper, hydroxyapatite (HA) powder was made out of bovine bone by thermal analysis at 900掳C and first, and then, porous HA (50 weight percentage) was produced by polyurethane sponge replication method. In order to improve the scaffold mechanical properties, they have been coated with poly hydroxybutyrate. In terms of phase studies, morphology, and specifying agent groups, the specific characterization devices such as X-ray diffraction and Fourier transform infrared, were employed. To compare the behavior of cellular scaffolds, they were divided into four groups of scaffolds. The osteoblast cells were cultured. To perform phase studies, analysis of Methylthiazole tetrazolium (MTT) and Trypan blue were carried out for the viability and attachment on the surface of the scaffold, and the specification of Scanning electron microscopy was employed for the morphology of the cells. The results of MTT analysis performed on four groups of scaffolds have shown that Titanium oxide (Tio2) had no effect on cell growth alone and HA was the main factor of growth and cell osteoblast adhesion on the scaffold. Moreover, the results showed that the use of coating with poly-3-hydroxybutyrate saved the factors and placed the osteoblasts within the pore. Since the main part of bone consists of HA, the TiO2 accelerates the formation of apatite crystals at the scaffold surface which is the evidence for bone tissue regeneration. It is likely that the relation between HA and TiO2 leads to an increase in osteoblast adhesion and growth of cells on the scaffold surface.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Advanced Biomedical Research"},"translated_abstract":"The generation of bioartificial bone tissues may help to overcome the problems related to donor site morbidity and size limitations. In this paper, hydroxyapatite (HA) powder was made out of bovine bone by thermal analysis at 900掳C and first, and then, porous HA (50 weight percentage) was produced by polyurethane sponge replication method. In order to improve the scaffold mechanical properties, they have been coated with poly hydroxybutyrate. In terms of phase studies, morphology, and specifying agent groups, the specific characterization devices such as X-ray diffraction and Fourier transform infrared, were employed. To compare the behavior of cellular scaffolds, they were divided into four groups of scaffolds. The osteoblast cells were cultured. To perform phase studies, analysis of Methylthiazole tetrazolium (MTT) and Trypan blue were carried out for the viability and attachment on the surface of the scaffold, and the specification of Scanning electron microscopy was employed for the morphology of the cells. The results of MTT analysis performed on four groups of scaffolds have shown that Titanium oxide (Tio2) had no effect on cell growth alone and HA was the main factor of growth and cell osteoblast adhesion on the scaffold. Moreover, the results showed that the use of coating with poly-3-hydroxybutyrate saved the factors and placed the osteoblasts within the pore. Since the main part of bone consists of HA, the TiO2 accelerates the formation of apatite crystals at the scaffold surface which is the evidence for bone tissue regeneration. It is likely that the relation between HA and TiO2 leads to an increase in osteoblast adhesion and growth of cells on the scaffold surface.","internal_url":"https://www.academia.edu/34032125/Evaluate_the_growth_and_adhesion_of_osteoblast_cells_on_nanocomposite_scaffold_of_hydroxyapatite_titania_coated_with_poly_hydroxybutyrate","translated_internal_url":"","created_at":"2017-07-25T08:47:14.571-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Evaluate_the_growth_and_adhesion_of_osteoblast_cells_on_nanocomposite_scaffold_of_hydroxyapatite_titania_coated_with_poly_hydroxybutyrate","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The generation of bioartificial bone tissues may help to overcome the problems related to donor site morbidity and size limitations. In this paper, hydroxyapatite (HA) powder was made out of bovine bone by thermal analysis at 900掳C and first, and then, porous HA (50 weight percentage) was produced by polyurethane sponge replication method. In order to improve the scaffold mechanical properties, they have been coated with poly hydroxybutyrate. In terms of phase studies, morphology, and specifying agent groups, the specific characterization devices such as X-ray diffraction and Fourier transform infrared, were employed. To compare the behavior of cellular scaffolds, they were divided into four groups of scaffolds. The osteoblast cells were cultured. To perform phase studies, analysis of Methylthiazole tetrazolium (MTT) and Trypan blue were carried out for the viability and attachment on the surface of the scaffold, and the specification of Scanning electron microscopy was employed for the morphology of the cells. The results of MTT analysis performed on four groups of scaffolds have shown that Titanium oxide (Tio2) had no effect on cell growth alone and HA was the main factor of growth and cell osteoblast adhesion on the scaffold. Moreover, the results showed that the use of coating with poly-3-hydroxybutyrate saved the factors and placed the osteoblasts within the pore. Since the main part of bone consists of HA, the TiO2 accelerates the formation of apatite crystals at the scaffold surface which is the evidence for bone tissue regeneration. It is likely that the relation between HA and TiO2 leads to an increase in osteoblast adhesion and growth of cells on the scaffold surface.","owner":{"id":66499940,"first_name":"Saeed","middle_initials":null,"last_name":"Karbasi","page_name":"SaeedKarbasi","domain_name":"mui","created_at":"2017-07-17T06:31:55.223-07:00","display_name":"Saeed Karbasi","url":"https://mui.academia.edu/SaeedKarbasi"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032125-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032124"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/34032124/Evaluation_of_Structural_Mechanical_and_Cellular_Behavior_of_Electrospunpoly3_hydroxybutyrate_Scaffolds_Loaded_with_Glucosamine_Sulfate_to_Develop_Cartilage_Tissue_Engineering"><img alt="Research paper thumbnail of Evaluation of Structural, Mechanical and Cellular Behavior of Electrospunpoly3-hydroxybutyrate Scaffolds Loaded with Glucosamine Sulfate to Develop Cartilage Tissue Engineering" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Evaluation of Structural, Mechanical and Cellular Behavior of Electrospunpoly3-hydroxybutyrate Scaffolds Loaded with Glucosamine Sulfate to Develop Cartilage Tissue Engineering</div><div class="wp-workCard_item"><span>International Journal of Polymeric Materials and Polymeric Biomaterials</span><span>, 2017</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032124"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032124"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032124; 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Dip-coating method was used for the films preparation. The morphology, structure and composition of the nano composite films were evaluated using environmental scanning electron microscope, X-ray diffraction and Fourier transform infrared spectroscope. The SEM investigation results showed that prepared thick NBG-titania films are smooth and free of macrocracking, fracture or flaking. The grain size of these films was uniform and nano scale (50-60 nm) which confirmed with TEM. Also FTIR confirmed the presence of Si-O-Si bands on the calcinated NBG-titania films. The hardness of the prepared films (TiO 2 -calcinated NBG and TiO 2 -Non calcinated NBG) was compared by using micro hardness test method. The results verified that the presence of calcinated NBG particles in NBG-titania composite enhanced gradually the mechanical data of the prepared films. The in vitro bioactivity of these films was discussed based on the analysis of the variations of Ca and P concentrations in the simulated body fluid (SBF) and their surface morphologies against immersion time. Surface morphology and Si-O-Si bands were found to be of great importance with respect to the bioactivity of the studied films. The results showed that calcinated NBGtitania films have better bioactivity than non calcinated NBG-titania films.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a461cd2a8a6eea9610322a1981e05de" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53973272,"asset_id":34032118,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53973272/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032118"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032118"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032118; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032118]").text(description); $(".js-view-count[data-work-id=34032118]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032118; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032118']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8a461cd2a8a6eea9610322a1981e05de" } } $('.js-work-strip[data-work-id=34032118]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032118,"title":"Influence of calcinated and non calcinated nanobioglass particles on hardness and bioactivity of sol-gel-derived TiO 2 -SiO 2 nano composite coatings on stainless steel substrates","translated_title":"","metadata":{"grobid_abstract":"Thick films of calcinated and non calcinated nanobioglass (NBG)-titania composite coatings were prepared on stainless steel substrates by alkoxide sol-gel process. 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Dip-coating method was used for the films preparation. The morphology, structure and composition of the nano composite films were evaluated using environmental scanning electron microscope, X-ray diffraction and Fourier transform infrared spectroscope. The SEM investigation results showed that prepared thick NBG-titania films are smooth and free of macrocracking, fracture or flaking. The grain size of these films was uniform and nano scale (50-60 nm) which confirmed with TEM. Also FTIR confirmed the presence of Si-O-Si bands on the calcinated NBG-titania films. The hardness of the prepared films (TiO 2 -calcinated NBG and TiO 2 -Non calcinated NBG) was compared by using micro hardness test method. The results verified that the presence of calcinated NBG particles in NBG-titania composite enhanced gradually the mechanical data of the prepared films. The in vitro bioactivity of these films was discussed based on the analysis of the variations of Ca and P concentrations in the simulated body fluid (SBF) and their surface morphologies against immersion time. Surface morphology and Si-O-Si bands were found to be of great importance with respect to the bioactivity of the studied films. The results showed that calcinated NBGtitania films have better bioactivity than non calcinated NBG-titania films.","owner":{"id":66499940,"first_name":"Saeed","middle_initials":null,"last_name":"Karbasi","page_name":"SaeedKarbasi","domain_name":"mui","created_at":"2017-07-17T06:31:55.223-07:00","display_name":"Saeed Karbasi","url":"https://mui.academia.edu/SaeedKarbasi"},"attachments":[{"id":53973272,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973272/thumbnails/1.jpg","file_name":"Influence_of_calcinated_and_non_calcinat20170725-25620-r3j3r3.pdf","download_url":"https://www.academia.edu/attachments/53973272/download_file","bulk_download_file_name":"Influence_of_calcinated_and_non_calcinat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973272/Influence_of_calcinated_and_non_calcinat20170725-25620-r3j3r3-libre.pdf?1500997974=\u0026response-content-disposition=attachment%3B+filename%3DInfluence_of_calcinated_and_non_calcinat.pdf\u0026Expires=1743370487\u0026Signature=QDvuSY5r9urtXACTo2bfnktk~PXhbnX5B~QjDJbWDl95QJCtQk4wekdmX-8fXy7vbPZx1m5MAbAy6j0y-0BvR1Gf-bv1x-cm9tJ8mdfdtpHkL-Wm0L6T5dqbQ6w9Ex~DNOEPSNoJa5PJ~4erg2ojh1oVLlh94iOf6SVXI~neI0Xbr1vX6ruf2hdDY86oE7q1rrnxxVUP5kfqPx~8RM4LDs253xuyYP56JQ0puT9ISMmiRLdtJcb9LTZ1EC0nyoW752DUrVqWvvxS39FmHVTSA-RDZmcGsMoieHFydu4cTzE54ydRKfrQZ6SzhmpEspKXVd8mYEzWhhXzTWayLTJQTg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":56,"name":"Materials Engineering","url":"https://www.academia.edu/Documents/in/Materials_Engineering"},{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":7742,"name":"Glass","url":"https://www.academia.edu/Documents/in/Glass"},{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium"},{"id":10650,"name":"Materials","url":"https://www.academia.edu/Documents/in/Materials"},{"id":10655,"name":"Scanning Electron Microscopy","url":"https://www.academia.edu/Documents/in/Scanning_Electron_Microscopy"},{"id":11404,"name":"Titanium","url":"https://www.academia.edu/Documents/in/Titanium"},{"id":11678,"name":"Nanocomposites","url":"https://www.academia.edu/Documents/in/Nanocomposites"},{"id":35056,"name":"Metal Nanoparticles","url":"https://www.academia.edu/Documents/in/Metal_Nanoparticles"},{"id":58906,"name":"Fourier Analysis","url":"https://www.academia.edu/Documents/in/Fourier_Analysis"},{"id":85460,"name":"Sol Gel Process","url":"https://www.academia.edu/Documents/in/Sol_Gel_Process"},{"id":128789,"name":"Stainless Steel","url":"https://www.academia.edu/Documents/in/Stainless_Steel"},{"id":173963,"name":"Phase transition","url":"https://www.academia.edu/Documents/in/Phase_transition"},{"id":176678,"name":"Hardness","url":"https://www.academia.edu/Documents/in/Hardness"},{"id":186099,"name":"Grain size","url":"https://www.academia.edu/Documents/in/Grain_size"},{"id":186264,"name":"Surface Morphology","url":"https://www.academia.edu/Documents/in/Surface_Morphology"},{"id":386527,"name":"X ray diffraction","url":"https://www.academia.edu/Documents/in/X_ray_diffraction"},{"id":398650,"name":"Fourier transform infrared spectroscopy","url":"https://www.academia.edu/Documents/in/Fourier_transform_infrared_spectroscopy"},{"id":440924,"name":"Surface Properties","url":"https://www.academia.edu/Documents/in/Surface_Properties"},{"id":776363,"name":"Powders","url":"https://www.academia.edu/Documents/in/Powders"},{"id":1031067,"name":"Biocompatible Materials","url":"https://www.academia.edu/Documents/in/Biocompatible_Materials"},{"id":1031069,"name":"Silicon Dioxide","url":"https://www.academia.edu/Documents/in/Silicon_Dioxide"},{"id":1035713,"name":"Simulated Body Fluid","url":"https://www.academia.edu/Documents/in/Simulated_Body_Fluid"},{"id":1146508,"name":"Body Fluids","url":"https://www.academia.edu/Documents/in/Body_Fluids"},{"id":2243423,"name":"Fourier transform infrared","url":"https://www.academia.edu/Documents/in/Fourier_transform_infrared"},{"id":2736714,"name":"Test Methods","url":"https://www.academia.edu/Documents/in/Test_Methods"}],"urls":[{"id":8233191,"url":"http://springerlink.com/index/g8734715u135u437.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032118-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032117"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/34032117/Cell_Attachment_and_Proliferation_of_Human_Adipose_Derived_Stem_Cells_on_PLGA_Chitosan_Electrospun_Nano_Biocomposite"><img alt="Research paper thumbnail of Cell Attachment and Proliferation of Human Adipose-Derived Stem Cells on PLGA/Chitosan Electrospun Nano-Biocomposite" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Cell Attachment and Proliferation of Human Adipose-Derived Stem Cells on PLGA/Chitosan Electrospun Nano-Biocomposite</div><div class="wp-workCard_item"><span>Cell journal</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this study, nano-biocomposite composed of poly (lactide-co-glycolide) (PLGA) and chitosan (CS)...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this study, nano-biocomposite composed of poly (lactide-co-glycolide) (PLGA) and chitosan (CS) were electrospun through a single nozzle by dispersing the CS nano-powders in PLGA solution. The cellular behavior of human adipose derived stem cells (h-ADSCs) on random and aligned scaffolds was then evaluated. In this experimental study, the PLGA/CS scaffolds were prepared at the different ratios of 90/10, 80/20, and 70/30 (w/w) %. Morphology, cell adhesion and prolif- eration rate of h-ADSCs on the scaffolds were assessed using scanning electron microscope (SEM), 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and trypan blue staining respectively. H-ADSCs seeded on the matrices indicated that the PLGA/CS composite matrix with aligned nanofibres and higher content of CS nano-powders gave significantly better performance than others in terms of cell adhesion and proliferation rate (P&lt;0.05). We found that CS enhanced cell adhesion and proliferation rate,...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032117"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032117"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032117; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032117]").text(description); $(".js-view-count[data-work-id=34032117]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032117; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032117']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=34032117]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032117,"title":"Cell Attachment and Proliferation of Human Adipose-Derived Stem Cells on PLGA/Chitosan Electrospun Nano-Biocomposite","translated_title":"","metadata":{"abstract":"In this study, nano-biocomposite composed of poly (lactide-co-glycolide) (PLGA) and chitosan (CS) were electrospun through a single nozzle by dispersing the CS nano-powders in PLGA solution. The cellular behavior of human adipose derived stem cells (h-ADSCs) on random and aligned scaffolds was then evaluated. In this experimental study, the PLGA/CS scaffolds were prepared at the different ratios of 90/10, 80/20, and 70/30 (w/w) %. Morphology, cell adhesion and prolif- eration rate of h-ADSCs on the scaffolds were assessed using scanning electron microscope (SEM), 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and trypan blue staining respectively. H-ADSCs seeded on the matrices indicated that the PLGA/CS composite matrix with aligned nanofibres and higher content of CS nano-powders gave significantly better performance than others in terms of cell adhesion and proliferation rate (P\u0026lt;0.05). We found that CS enhanced cell adhesion and proliferation rate,...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Cell journal"},"translated_abstract":"In this study, nano-biocomposite composed of poly (lactide-co-glycolide) (PLGA) and chitosan (CS) were electrospun through a single nozzle by dispersing the CS nano-powders in PLGA solution. The cellular behavior of human adipose derived stem cells (h-ADSCs) on random and aligned scaffolds was then evaluated. In this experimental study, the PLGA/CS scaffolds were prepared at the different ratios of 90/10, 80/20, and 70/30 (w/w) %. Morphology, cell adhesion and prolif- eration rate of h-ADSCs on the scaffolds were assessed using scanning electron microscope (SEM), 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and trypan blue staining respectively. H-ADSCs seeded on the matrices indicated that the PLGA/CS composite matrix with aligned nanofibres and higher content of CS nano-powders gave significantly better performance than others in terms of cell adhesion and proliferation rate (P\u0026lt;0.05). We found that CS enhanced cell adhesion and proliferation rate,...","internal_url":"https://www.academia.edu/34032117/Cell_Attachment_and_Proliferation_of_Human_Adipose_Derived_Stem_Cells_on_PLGA_Chitosan_Electrospun_Nano_Biocomposite","translated_internal_url":"","created_at":"2017-07-25T08:47:13.180-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Cell_Attachment_and_Proliferation_of_Human_Adipose_Derived_Stem_Cells_on_PLGA_Chitosan_Electrospun_Nano_Biocomposite","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"In this study, nano-biocomposite composed of poly (lactide-co-glycolide) (PLGA) and chitosan (CS) were electrospun through a single nozzle by dispersing the CS nano-powders in PLGA solution. The cellular behavior of human adipose derived stem cells (h-ADSCs) on random and aligned scaffolds was then evaluated. In this experimental study, the PLGA/CS scaffolds were prepared at the different ratios of 90/10, 80/20, and 70/30 (w/w) %. Morphology, cell adhesion and prolif- eration rate of h-ADSCs on the scaffolds were assessed using scanning electron microscope (SEM), 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and trypan blue staining respectively. H-ADSCs seeded on the matrices indicated that the PLGA/CS composite matrix with aligned nanofibres and higher content of CS nano-powders gave significantly better performance than others in terms of cell adhesion and proliferation rate (P\u0026lt;0.05). We found that CS enhanced cell adhesion and proliferation rate,...","owner":{"id":66499940,"first_name":"Saeed","middle_initials":null,"last_name":"Karbasi","page_name":"SaeedKarbasi","domain_name":"mui","created_at":"2017-07-17T06:31:55.223-07:00","display_name":"Saeed Karbasi","url":"https://mui.academia.edu/SaeedKarbasi"},"attachments":[],"research_interests":[{"id":107533,"name":"Cell","url":"https://www.academia.edu/Documents/in/Cell"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032117-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032116"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/34032116/Novel_sol_gel_synthesis_and_characterization_of_nanostructured_hydroxyapatite_powder"><img alt="Research paper thumbnail of Novel sol鈥揼el synthesis and characterization of nanostructured hydroxyapatite powder" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Novel sol鈥揼el synthesis and characterization of nanostructured hydroxyapatite powder</div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Nanocrystalline powders of hydroxyapatite (HA) were prepared from Ca (NO 3) 2路 4H 2 O and P 2 O 5...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Nanocrystalline powders of hydroxyapatite (HA) were prepared from Ca (NO 3) 2路 4H 2 O and P 2 O 5 using a simple sol聳gel approach. The resultant gel precursors obtained based on the concentration of the starting solutions were either transparent or translucent. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032116"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032116"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032116; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032116]").text(description); $(".js-view-count[data-work-id=34032116]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032116; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032116']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=34032116]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032116,"title":"Novel sol鈥揼el synthesis and characterization of nanostructured hydroxyapatite powder","translated_title":"","metadata":{"abstract":"Nanocrystalline powders of hydroxyapatite (HA) were prepared from Ca (NO 3) 2路 4H 2 O and P 2 O 5 using a simple sol聳gel approach. The resultant gel precursors obtained based on the concentration of the starting solutions were either transparent or translucent. ...","publication_date":{"day":null,"month":null,"year":2010,"errors":{}}},"translated_abstract":"Nanocrystalline powders of hydroxyapatite (HA) were prepared from Ca (NO 3) 2路 4H 2 O and P 2 O 5 using a simple sol聳gel approach. The resultant gel precursors obtained based on the concentration of the starting solutions were either transparent or translucent. ...","internal_url":"https://www.academia.edu/34032116/Novel_sol_gel_synthesis_and_characterization_of_nanostructured_hydroxyapatite_powder","translated_internal_url":"","created_at":"2017-07-25T08:47:13.032-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Novel_sol_gel_synthesis_and_characterization_of_nanostructured_hydroxyapatite_powder","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Nanocrystalline powders of hydroxyapatite (HA) were prepared from Ca (NO 3) 2路 4H 2 O and P 2 O 5 using a simple sol聳gel approach. The resultant gel precursors obtained based on the concentration of the starting solutions were either transparent or translucent. ...","owner":{"id":66499940,"first_name":"Saeed","middle_initials":null,"last_name":"Karbasi","page_name":"SaeedKarbasi","domain_name":"mui","created_at":"2017-07-17T06:31:55.223-07:00","display_name":"Saeed Karbasi","url":"https://mui.academia.edu/SaeedKarbasi"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032116-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032115"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/34032115/Physical_and_mechanical_properties_of_a_poly_3_hydroxybutyratecoated_nanocrystalline_Bioglass_45S5_scaffold_for_bone_tissue_engineering"><img alt="Research paper thumbnail of Physical and mechanical properties of a poly-3-hydroxybutyratecoated nanocrystalline Bioglass 45S5 scaffold for bone tissue engineering" class="work-thumbnail" src="https://attachments.academia-assets.com/53973269/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/34032115/Physical_and_mechanical_properties_of_a_poly_3_hydroxybutyratecoated_nanocrystalline_Bioglass_45S5_scaffold_for_bone_tissue_engineering">Physical and mechanical properties of a poly-3-hydroxybutyratecoated nanocrystalline Bioglass 45S5 scaffold for bone tissue engineering</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A major challenge for tissue engineers is the design of scaffolds with appropriate physical and m...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A major challenge for tissue engineers is the design of scaffolds with appropriate physical and mechanical properties. The present research discusses the formation of ceramic scaffolding in tissue engineering. Hydroxyapatite (HAp) powder was made from bovine bone by thermal treatment at 900掳C; 40, 50 and 60%wt porous HAp was then produced using the polyurethane sponge replication method. Scaffolds were coated with poly-3hydroxybutyrate (P3HB) for 30 s and 1 min in order to increase the scaffold's mechanical properties. XRD, SEM and FT-IR were used to study phase structure, morphology and agent groups, respectively. In XRD and FT-IR data, established hydrogen bands between polymer and ceramic matrix confirm that the scaffold is formed as a composite. The scaffold obtained with 50%wt HAp and a 30 s coating was 90% porous, with an average diameter of 100-400 lm, and demonstrated a compressive strength and modulus of 1.46 and 21.27 MPa, respectively. Based on these results, this scaffold is optimised for the aforementioned properties and can be utilised in bone tissue engineering.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6ba86ac54912fd16cb94a3efc5fd2933" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53973269,"asset_id":34032115,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53973269/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032115"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032115"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032115; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032115]").text(description); $(".js-view-count[data-work-id=34032115]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032115; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032115']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6ba86ac54912fd16cb94a3efc5fd2933" } } $('.js-work-strip[data-work-id=34032115]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032115,"title":"Physical and mechanical properties of a poly-3-hydroxybutyratecoated nanocrystalline Bioglass 45S5 scaffold for bone tissue engineering","translated_title":"","metadata":{"grobid_abstract":"A major challenge for tissue engineers is the design of scaffolds with appropriate physical and mechanical properties. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032115-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032114"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/34032114/Optimization_of_silk_yarn_hierarchical_structure_by_genetic_algorithm_to_design_scaffolds"><img alt="Research paper thumbnail of Optimization of silk yarn hierarchical structure by genetic algorithm to design scaffolds" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Optimization of silk yarn hierarchical structure by genetic algorithm to design scaffolds</div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://mui.academia.edu/SaeedKarbasi">Saeed Karbasi</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://iut.academia.edu/DariushSemnani">Dariush Semnani</a></span></div><div class="wp-workCard_item"><span>Indian Journal of Fibre Textile Research</span><span>, Mar 27, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032114"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032114"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032114; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032114-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032113"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/34032113/A_Comparison_between_Cell_Viability_of_Chondrocytes_on_a_Biodegradable_Polyester_Urethane_Scaffold_and_Alginate_Beads_in_Different_Oxygen_Tension_and_pH"><img alt="Research paper thumbnail of A Comparison between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and pH" class="work-thumbnail" src="https://attachments.academia-assets.com/53973282/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/34032113/A_Comparison_between_Cell_Viability_of_Chondrocytes_on_a_Biodegradable_Polyester_Urethane_Scaffold_and_Alginate_Beads_in_Different_Oxygen_Tension_and_pH">A Comparison between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and pH</a></div><div class="wp-workCard_item"><span>Iranian Polymer Journal</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">C artilage is a tissue that has a low potential for self-repair. One of the methods for improveme...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">C artilage is a tissue that has a low potential for self-repair. One of the methods for improvement of regeneration and metabolism in cartilge, is to stimulate physical factors on chondrocytes as cartilage based cells. In this research, two physical factors, oxygen tension and pH, were changed to measure the cell viability of chondrocytes on Degrapol庐, as a biodegradable polyurethane (DBS), and alginate scaffolds and cell viability onto these substrates are compared. The results showed that, physical factors like oxygen and pH could change cell viability. After 3 days cell culture for both types of scaffolds, the cell viability was higher with 5% O 2 and pH=7.4 and it was not dependent on the type of scaffolds. Our results showed that cell viability on alginate beads is more than DBS scaffold for different conditions. chondrocyte; physical environment; Biodegradation; polyester urethane (Degrapol庐); alginate; cell viability.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="58f9470732d7ba3d65b84707973540a8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53973282,"asset_id":34032113,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53973282/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032113"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032113"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032113; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032113]").text(description); $(".js-view-count[data-work-id=34032113]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032113; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032113']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "58f9470732d7ba3d65b84707973540a8" } } $('.js-work-strip[data-work-id=34032113]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032113,"title":"A Comparison between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and pH","translated_title":"","metadata":{"ai_title_tag":"Chondrocyte Viability in Biodegradable Scaffolds","grobid_abstract":"C artilage is a tissue that has a low potential for self-repair. One of the methods for improvement of regeneration and metabolism in cartilge, is to stimulate physical factors on chondrocytes as cartilage based cells. In this research, two physical factors, oxygen tension and pH, were changed to measure the cell viability of chondrocytes on Degrapol庐, as a biodegradable polyurethane (DBS), and alginate scaffolds and cell viability onto these substrates are compared. The results showed that, physical factors like oxygen and pH could change cell viability. After 3 days cell culture for both types of scaffolds, the cell viability was higher with 5% O 2 and pH=7.4 and it was not dependent on the type of scaffolds. Our results showed that cell viability on alginate beads is more than DBS scaffold for different conditions. chondrocyte; physical environment; Biodegradation; polyester urethane (Degrapol庐); alginate; cell viability.","publication_name":"Iranian Polymer Journal","grobid_abstract_attachment_id":53973282},"translated_abstract":null,"internal_url":"https://www.academia.edu/34032113/A_Comparison_between_Cell_Viability_of_Chondrocytes_on_a_Biodegradable_Polyester_Urethane_Scaffold_and_Alginate_Beads_in_Different_Oxygen_Tension_and_pH","translated_internal_url":"","created_at":"2017-07-25T08:47:12.491-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":29854075,"work_id":34032113,"tagging_user_id":66499940,"tagged_user_id":38385151,"co_author_invite_id":null,"email":"j***n@dpag.ox.ac.uk","display_order":0,"name":"J. Urban","title":"A Comparison between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and pH"},{"id":29854076,"work_id":34032113,"tagging_user_id":66499940,"tagged_user_id":260764066,"co_author_invite_id":696639,"email":"m***h@aut.ac.ir","display_order":4194304,"name":"Hamid Mirzadeh","title":"A Comparison between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and pH"},{"id":29854077,"work_id":34032113,"tagging_user_id":66499940,"tagged_user_id":null,"co_author_invite_id":6452192,"email":"s***4@aut.ac.ir","display_order":6291456,"name":"Fariba Orang","title":"A Comparison between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and pH"}],"downloadable_attachments":[{"id":53973282,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973282/thumbnails/1.jpg","file_name":"81320050908.pdf","download_url":"https://www.academia.edu/attachments/53973282/download_file","bulk_download_file_name":"A_Comparison_between_Cell_Viability_of_C.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973282/81320050908-libre.pdf?1500998105=\u0026response-content-disposition=attachment%3B+filename%3DA_Comparison_between_Cell_Viability_of_C.pdf\u0026Expires=1743370487\u0026Signature=SYbIoRSClaxZBI2-rjWL1QKub72kzOHM4rywVbKXYrRCRQ14jIAmTBq4YBAFhOhzlER2TONzzmMMC9KwEq8OBSilawpLF2ao~AkDCpNAURezF-kAkRzJyIgb~0JqF9Kbel70d8PtMrop5PacuhO5MdWvUkp7bHOe3rei8j-nM2QOuRovnEj0CA1G5nfjjx4jn-0HQnC7~-91f6GFGsl-8CzY4aFxAbEvmSL3O80tdrpFZRFlIWCHzlkoCoFx5oTw7Y1s~DnmF0jOiCh4sRWDMEcqGgx8ObxCXOX7o12iBOm351P1Oq7KCQ9FznAxrJc9Tmm-ZrVoj-cxVIyktIKt4Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_Comparison_between_Cell_Viability_of_Chondrocytes_on_a_Biodegradable_Polyester_Urethane_Scaffold_and_Alginate_Beads_in_Different_Oxygen_Tension_and_pH","translated_slug":"","page_count":8,"language":"en","content_type":"Work","summary":"C artilage is a tissue that has a low potential for self-repair. One of the methods for improvement of regeneration and metabolism in cartilge, is to stimulate physical factors on chondrocytes as cartilage based cells. In this research, two physical factors, oxygen tension and pH, were changed to measure the cell viability of chondrocytes on Degrapol庐, as a biodegradable polyurethane (DBS), and alginate scaffolds and cell viability onto these substrates are compared. The results showed that, physical factors like oxygen and pH could change cell viability. After 3 days cell culture for both types of scaffolds, the cell viability was higher with 5% O 2 and pH=7.4 and it was not dependent on the type of scaffolds. Our results showed that cell viability on alginate beads is more than DBS scaffold for different conditions. chondrocyte; physical environment; Biodegradation; polyester urethane (Degrapol庐); alginate; cell viability.","owner":{"id":66499940,"first_name":"Saeed","middle_initials":null,"last_name":"Karbasi","page_name":"SaeedKarbasi","domain_name":"mui","created_at":"2017-07-17T06:31:55.223-07:00","display_name":"Saeed Karbasi","url":"https://mui.academia.edu/SaeedKarbasi"},"attachments":[{"id":53973282,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973282/thumbnails/1.jpg","file_name":"81320050908.pdf","download_url":"https://www.academia.edu/attachments/53973282/download_file","bulk_download_file_name":"A_Comparison_between_Cell_Viability_of_C.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973282/81320050908-libre.pdf?1500998105=\u0026response-content-disposition=attachment%3B+filename%3DA_Comparison_between_Cell_Viability_of_C.pdf\u0026Expires=1743370487\u0026Signature=SYbIoRSClaxZBI2-rjWL1QKub72kzOHM4rywVbKXYrRCRQ14jIAmTBq4YBAFhOhzlER2TONzzmMMC9KwEq8OBSilawpLF2ao~AkDCpNAURezF-kAkRzJyIgb~0JqF9Kbel70d8PtMrop5PacuhO5MdWvUkp7bHOe3rei8j-nM2QOuRovnEj0CA1G5nfjjx4jn-0HQnC7~-91f6GFGsl-8CzY4aFxAbEvmSL3O80tdrpFZRFlIWCHzlkoCoFx5oTw7Y1s~DnmF0jOiCh4sRWDMEcqGgx8ObxCXOX7o12iBOm351P1Oq7KCQ9FznAxrJc9Tmm-ZrVoj-cxVIyktIKt4Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":165002,"name":"Cell Viability","url":"https://www.academia.edu/Documents/in/Cell_Viability"},{"id":575534,"name":"Physical Environment","url":"https://www.academia.edu/Documents/in/Physical_Environment"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032113-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032112"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/34032112/Evaluation_of_the_Effects_of_Hydrostatic_Pressure_on_Metabolism_of_the_Articular_Chondrocytes_Seeded_on_Biodegradable_Polyurethane_as_Tissue_Engineering_Scaffold"><img alt="Research paper thumbnail of Evaluation of the Effects of Hydrostatic Pressure on Metabolism of the Articular Chondrocytes Seeded on Biodegradable Polyurethane as Tissue Engineering Scaffold" class="work-thumbnail" src="https://attachments.academia-assets.com/53973267/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/34032112/Evaluation_of_the_Effects_of_Hydrostatic_Pressure_on_Metabolism_of_the_Articular_Chondrocytes_Seeded_on_Biodegradable_Polyurethane_as_Tissue_Engineering_Scaffold">Evaluation of the Effects of Hydrostatic Pressure on Metabolism of the Articular Chondrocytes Seeded on Biodegradable Polyurethane as Tissue Engineering Scaffold</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">One of the most effective parameters in articular cartilage tissue engineering is cell stimulatio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">One of the most effective parameters in articular cartilage tissue engineering is cell stimulation and growth. Using a reaction system, which incorporates many of the same conditions as an articulating joint such as intermittent loading, long term culture and a suitable 3-D growth environment could stimulate chondrocytes metabolism. It has been demonstrated that hydrostatic pressure, as a physicochemical parameter, also could increase chondrocytes metabolism in tissue constructs. In this research, the effect of hydrostatic pressure was investigated on lactate production and GAG (glycosaminoglycan) content produced by chondrocytes. The isolated chondrocytes from animal joint, were seeded on a biodegradable polyesterurethane scaffold (BPUS) namely DegraPol 庐 and then, 4 MPa was applied to the samples for 4 hours per day as a cyclic (1 HZ, Sinusoidal) load. The results showed that in constant physicochemical conditions, the hydrostatic pressure could increase the amount of lactate (P<0.001), rate of lactate production (P<0.001) and GAG (P<0.01) as a significant cartilage metabolism on BPUS. In comparison to other biodegradable polymers, this research was showed that BPUS has great potential for articular cartilage tissue engineering, in vitro.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="136a89eddb647ea46c8f5cf96d96faac" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53973267,"asset_id":34032112,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53973267/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032112"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032112"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032112; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032112]").text(description); $(".js-view-count[data-work-id=34032112]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032112; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032112']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "136a89eddb647ea46c8f5cf96d96faac" } } $('.js-work-strip[data-work-id=34032112]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032112,"title":"Evaluation of the Effects of Hydrostatic Pressure on Metabolism of the Articular Chondrocytes Seeded on Biodegradable Polyurethane as Tissue Engineering Scaffold","translated_title":"","metadata":{"grobid_abstract":"One of the most effective parameters in articular cartilage tissue engineering is cell stimulation and growth. Using a reaction system, which incorporates many of the same conditions as an articulating joint such as intermittent loading, long term culture and a suitable 3-D growth environment could stimulate chondrocytes metabolism. It has been demonstrated that hydrostatic pressure, as a physicochemical parameter, also could increase chondrocytes metabolism in tissue constructs. In this research, the effect of hydrostatic pressure was investigated on lactate production and GAG (glycosaminoglycan) content produced by chondrocytes. The isolated chondrocytes from animal joint, were seeded on a biodegradable polyesterurethane scaffold (BPUS) namely DegraPol 庐 and then, 4 MPa was applied to the samples for 4 hours per day as a cyclic (1 HZ, Sinusoidal) load. The results showed that in constant physicochemical conditions, the hydrostatic pressure could increase the amount of lactate (P\u003c0.001), rate of lactate production (P\u003c0.001) and GAG (P\u003c0.01) as a significant cartilage metabolism on BPUS. In comparison to other biodegradable polymers, this research was showed that BPUS has great potential for articular cartilage tissue engineering, in vitro.","grobid_abstract_attachment_id":53973267},"translated_abstract":null,"internal_url":"https://www.academia.edu/34032112/Evaluation_of_the_Effects_of_Hydrostatic_Pressure_on_Metabolism_of_the_Articular_Chondrocytes_Seeded_on_Biodegradable_Polyurethane_as_Tissue_Engineering_Scaffold","translated_internal_url":"","created_at":"2017-07-25T08:47:12.328-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":53973267,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973267/thumbnails/1.jpg","file_name":"Evaluation_of_the_Effects_of_Hydrostatic20170725-25623-tdal2r.pdf","download_url":"https://www.academia.edu/attachments/53973267/download_file","bulk_download_file_name":"Evaluation_of_the_Effects_of_Hydrostatic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973267/Evaluation_of_the_Effects_of_Hydrostatic20170725-25623-tdal2r-libre.pdf?1500997983=\u0026response-content-disposition=attachment%3B+filename%3DEvaluation_of_the_Effects_of_Hydrostatic.pdf\u0026Expires=1743370487\u0026Signature=gdyTNDLqSMGyA9tT~v0D4Ft~YFk2twGxVWyITHLPTHO994Gnz7RAsiBuzkx8YUmNJ7cUswqQ0yren1JdYXMDyxIaqdqUic8~eOMYOKanX785AUghnS7FooxsVk7GIJTcziwZyIQTrLhzrfxyTkF0Z0xVrfk6zGUMczkCourc~JTPmurP~MboLhNuxMz6Y~LWzDF5ryKIOFPoze2SmIxC3~dCt-n8Wrwl-jjzFNmsUTHWPPKK5MRJGO4FHnm29QhRtbJkBiC0oQ2m7VnPVsncVVte4NambRmt4IlAkKPWGcyyYJYdQUOjgbnPoOAzO1oAfBC5cIi6hlfgcsUQ52IXPg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Evaluation_of_the_Effects_of_Hydrostatic_Pressure_on_Metabolism_of_the_Articular_Chondrocytes_Seeded_on_Biodegradable_Polyurethane_as_Tissue_Engineering_Scaffold","translated_slug":"","page_count":8,"language":"en","content_type":"Work","summary":"One of the most effective parameters in articular cartilage tissue engineering is cell stimulation and growth. Using a reaction system, which incorporates many of the same conditions as an articulating joint such as intermittent loading, long term culture and a suitable 3-D growth environment could stimulate chondrocytes metabolism. It has been demonstrated that hydrostatic pressure, as a physicochemical parameter, also could increase chondrocytes metabolism in tissue constructs. In this research, the effect of hydrostatic pressure was investigated on lactate production and GAG (glycosaminoglycan) content produced by chondrocytes. The isolated chondrocytes from animal joint, were seeded on a biodegradable polyesterurethane scaffold (BPUS) namely DegraPol 庐 and then, 4 MPa was applied to the samples for 4 hours per day as a cyclic (1 HZ, Sinusoidal) load. The results showed that in constant physicochemical conditions, the hydrostatic pressure could increase the amount of lactate (P\u003c0.001), rate of lactate production (P\u003c0.001) and GAG (P\u003c0.01) as a significant cartilage metabolism on BPUS. In comparison to other biodegradable polymers, this research was showed that BPUS has great potential for articular cartilage tissue engineering, in vitro.","owner":{"id":66499940,"first_name":"Saeed","middle_initials":null,"last_name":"Karbasi","page_name":"SaeedKarbasi","domain_name":"mui","created_at":"2017-07-17T06:31:55.223-07:00","display_name":"Saeed Karbasi","url":"https://mui.academia.edu/SaeedKarbasi"},"attachments":[{"id":53973267,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973267/thumbnails/1.jpg","file_name":"Evaluation_of_the_Effects_of_Hydrostatic20170725-25623-tdal2r.pdf","download_url":"https://www.academia.edu/attachments/53973267/download_file","bulk_download_file_name":"Evaluation_of_the_Effects_of_Hydrostatic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973267/Evaluation_of_the_Effects_of_Hydrostatic20170725-25623-tdal2r-libre.pdf?1500997983=\u0026response-content-disposition=attachment%3B+filename%3DEvaluation_of_the_Effects_of_Hydrostatic.pdf\u0026Expires=1743370487\u0026Signature=gdyTNDLqSMGyA9tT~v0D4Ft~YFk2twGxVWyITHLPTHO994Gnz7RAsiBuzkx8YUmNJ7cUswqQ0yren1JdYXMDyxIaqdqUic8~eOMYOKanX785AUghnS7FooxsVk7GIJTcziwZyIQTrLhzrfxyTkF0Z0xVrfk6zGUMczkCourc~JTPmurP~MboLhNuxMz6Y~LWzDF5ryKIOFPoze2SmIxC3~dCt-n8Wrwl-jjzFNmsUTHWPPKK5MRJGO4FHnm29QhRtbJkBiC0oQ2m7VnPVsncVVte4NambRmt4IlAkKPWGcyyYJYdQUOjgbnPoOAzO1oAfBC5cIi6hlfgcsUQ52IXPg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032112-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032111"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/34032111/Effect_Of_Grafting_N_Vinyl_Pyrollidone_or_Acrylic_Acid_on_Cytotoxicity_Water_Absorption_and_Compression_Modulus_of_Crosslinked_Polyvinyl_Alcohol_as_Artificial_Cartilage"><img alt="Research paper thumbnail of Effect Of Grafting N-Vinyl Pyrollidone or Acrylic Acid on Cytotoxicity, Water Absorption, and Compression Modulus of Crosslinked Polyvinyl Alcohol as Artificial Cartilage" class="work-thumbnail" src="https://attachments.academia-assets.com/53973268/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/34032111/Effect_Of_Grafting_N_Vinyl_Pyrollidone_or_Acrylic_Acid_on_Cytotoxicity_Water_Absorption_and_Compression_Modulus_of_Crosslinked_Polyvinyl_Alcohol_as_Artificial_Cartilage">Effect Of Grafting N-Vinyl Pyrollidone or Acrylic Acid on Cytotoxicity, Water Absorption, and Compression Modulus of Crosslinked Polyvinyl Alcohol as Artificial Cartilage</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Articular cartilage is a thin layer covering the opposed bony faces, which aids in force absorpti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Articular cartilage is a thin layer covering the opposed bony faces, which aids in force absorption and acts as a low friction bearing for the two surfaces of the joint. Osteoarthritis results in a wearing away of this material which results in an increase in friction, stiffness, and pain. fully saturated natural cartilage contains 70-80 percent water. Hydrogels based on polyvinyl alcohol (PVA) have excellent biocompatibility and mechanical properties, however their maximum water absorption capacity is around 40%. The objective of this research was to investigate the effect of gamma radiation grafting of acrylic acid (AA) or N-vinyl pyrollidone (NVP) on water absorption, compression modulus, and biocompatibility of semicrystalline PVA hydrogel as an artificial carthage. PVA hydrogel was prepared as follows. A 10% w/w solution of PVA with greater than 99.4% saponification was prepared in distilled boiling water to allow complete dissolution. The solution was placed in an oven at 100掳C for 2 h in order for water to evaporate. The dried films were annealed in a vacuum oven at 120掳C for 1 h at 30 mmHg pressure to induce maximum crystallization of PVA. Samples were allowed to swell in distilled water for at least 48 h. After reaching equilibrium swelling, different amounts of purified AA or NV? ranging from 5 to 30% based on PVA was added to the aqueous solution, poured in a glass vial, purged with nitrogen, sealed with plastic top, and each vial was exposed to gamma radiation. After irradiation, the samples were washed twice with distilled water to remove uncrosslinked polymer and dried in vaccu at 40掳C for 12 h. The percent grafting was determined by measuring the weight of dry sample before and after irradiation. The percent swelling was determined by measuring the weight of swollen and dry sample in phosphate buffer solution with pH 7. for biocompatibility, Cell culture was performed using the ASTM-F813 standard procedure. Samples were sterilized by UV radiation and subsequent washing with ethanol and placed in sterilized peth dishes containing the culture medium at 37掳C. Antibacterial agents Penicillin G and Streptomycin were added to the petri dish in order to deactivate any remaining bacteria. Fibroblast cells, obtained from fran Pasture Institute, with concentration of 1 .3x105 cell/mi were added to each pen-i dish and placed in a CO, incubator at 37掳C for 24 h. After cell culture, the samples were washed with PBS buffer. The remaining cells on the surface after washing were fixed with gluteraldhyde and stained with trepan blue for microscopic observation. Ungrafted PVA had about 40% by weight water absorption. When PVA was grafted with 10%, 20% and 30% AA, water absorption increased to 45%, 50% and 55%. On the other hand, when PVA was grafted with 10%, 20%, and 30% NVP, water absorption increased to 65%, 72% and 78%. As the PVA was grafted with 10%, 20% and 30% AA, cell toxicity increased significantly such that no cell growth was observed on the sample with 30% grafted AA. On the other hand, as the PVA was grafted with 10%, 20%, and 30% NVP, cell compatibility increased significantly compared with ungrafted PVA. Also, the NVP grafted PVA samples also had higher compression modulus. Therefore, the results indicate that the NV? grafted PVA is more suitable for use as artificial cartilage compared to ungrafted PVA.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4494d1f11c289886a85714bab0477e1c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53973268,"asset_id":34032111,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53973268/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032111"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032111"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032111; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032111]").text(description); $(".js-view-count[data-work-id=34032111]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032111; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032111']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4494d1f11c289886a85714bab0477e1c" } } $('.js-work-strip[data-work-id=34032111]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032111,"title":"Effect Of Grafting N-Vinyl Pyrollidone or Acrylic Acid on Cytotoxicity, Water Absorption, and Compression Modulus of Crosslinked Polyvinyl Alcohol as Artificial Cartilage","translated_title":"","metadata":{"grobid_abstract":"Articular cartilage is a thin layer covering the opposed bony faces, which aids in force absorption and acts as a low friction bearing for the two surfaces of the joint. Osteoarthritis results in a wearing away of this material which results in an increase in friction, stiffness, and pain. fully saturated natural cartilage contains 70-80 percent water. Hydrogels based on polyvinyl alcohol (PVA) have excellent biocompatibility and mechanical properties, however their maximum water absorption capacity is around 40%. The objective of this research was to investigate the effect of gamma radiation grafting of acrylic acid (AA) or N-vinyl pyrollidone (NVP) on water absorption, compression modulus, and biocompatibility of semicrystalline PVA hydrogel as an artificial carthage. PVA hydrogel was prepared as follows. A 10% w/w solution of PVA with greater than 99.4% saponification was prepared in distilled boiling water to allow complete dissolution. The solution was placed in an oven at 100掳C for 2 h in order for water to evaporate. The dried films were annealed in a vacuum oven at 120掳C for 1 h at 30 mmHg pressure to induce maximum crystallization of PVA. Samples were allowed to swell in distilled water for at least 48 h. After reaching equilibrium swelling, different amounts of purified AA or NV? ranging from 5 to 30% based on PVA was added to the aqueous solution, poured in a glass vial, purged with nitrogen, sealed with plastic top, and each vial was exposed to gamma radiation. After irradiation, the samples were washed twice with distilled water to remove uncrosslinked polymer and dried in vaccu at 40掳C for 12 h. The percent grafting was determined by measuring the weight of dry sample before and after irradiation. The percent swelling was determined by measuring the weight of swollen and dry sample in phosphate buffer solution with pH 7. for biocompatibility, Cell culture was performed using the ASTM-F813 standard procedure. Samples were sterilized by UV radiation and subsequent washing with ethanol and placed in sterilized peth dishes containing the culture medium at 37掳C. Antibacterial agents Penicillin G and Streptomycin were added to the petri dish in order to deactivate any remaining bacteria. Fibroblast cells, obtained from fran Pasture Institute, with concentration of 1 .3x105 cell/mi were added to each pen-i dish and placed in a CO, incubator at 37掳C for 24 h. After cell culture, the samples were washed with PBS buffer. The remaining cells on the surface after washing were fixed with gluteraldhyde and stained with trepan blue for microscopic observation. Ungrafted PVA had about 40% by weight water absorption. When PVA was grafted with 10%, 20% and 30% AA, water absorption increased to 45%, 50% and 55%. On the other hand, when PVA was grafted with 10%, 20%, and 30% NVP, water absorption increased to 65%, 72% and 78%. As the PVA was grafted with 10%, 20% and 30% AA, cell toxicity increased significantly such that no cell growth was observed on the sample with 30% grafted AA. On the other hand, as the PVA was grafted with 10%, 20%, and 30% NVP, cell compatibility increased significantly compared with ungrafted PVA. Also, the NVP grafted PVA samples also had higher compression modulus. Therefore, the results indicate that the NV? grafted PVA is more suitable for use as artificial cartilage compared to ungrafted PVA.","grobid_abstract_attachment_id":53973268},"translated_abstract":null,"internal_url":"https://www.academia.edu/34032111/Effect_Of_Grafting_N_Vinyl_Pyrollidone_or_Acrylic_Acid_on_Cytotoxicity_Water_Absorption_and_Compression_Modulus_of_Crosslinked_Polyvinyl_Alcohol_as_Artificial_Cartilage","translated_internal_url":"","created_at":"2017-07-25T08:47:12.104-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":29854087,"work_id":34032111,"tagging_user_id":66499940,"tagged_user_id":32340991,"co_author_invite_id":null,"email":"j***i@engr.sc.edu","affiliation":"University of South Carolina","display_order":0,"name":"Esmaiel Jabbari","title":"Effect Of Grafting N-Vinyl Pyrollidone or Acrylic Acid on Cytotoxicity, Water Absorption, and Compression Modulus of Crosslinked Polyvinyl Alcohol as Artificial Cartilage"}],"downloadable_attachments":[{"id":53973268,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973268/thumbnails/1.jpg","file_name":"Effect_Of_Grafting_N-Vinyl_Pyrollidone_o20170725-25623-nyov1u.pdf","download_url":"https://www.academia.edu/attachments/53973268/download_file","bulk_download_file_name":"Effect_Of_Grafting_N_Vinyl_Pyrollidone_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973268/Effect_Of_Grafting_N-Vinyl_Pyrollidone_o20170725-25623-nyov1u-libre.pdf?1500997978=\u0026response-content-disposition=attachment%3B+filename%3DEffect_Of_Grafting_N_Vinyl_Pyrollidone_o.pdf\u0026Expires=1743370487\u0026Signature=GETe~3Bq8Pu9l3C0m~TsbyJDNqYT~wV4mWFwEZp0i192BRqoL9AR8EI1tus2ie06UghvxB6WTLPZVauoZ4yYbYQswVZYdNAlHsC6E9qh8q0lCdZwjuFrBtMU04NdpbbEmxjMU~23UoZEcIgzaOU99u-XXExrsqFNU8yxs1jpc9eA-h-tyzeFhGwZ2qsFC1uwzXMY3wuRj5LG6XzRcb0KWAH8oUYNyAtMHz-yatDq6EoL5SUQ09PVE5zFJ8mk4hpjTrSsUowNGtGudFwDABZM84qM3FSp0VN5XXcfm2sxKjQdVi8CDfcLDCxCsMa1t26I-wvPHn9nxcEpeS9SHcgfbw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effect_Of_Grafting_N_Vinyl_Pyrollidone_or_Acrylic_Acid_on_Cytotoxicity_Water_Absorption_and_Compression_Modulus_of_Crosslinked_Polyvinyl_Alcohol_as_Artificial_Cartilage","translated_slug":"","page_count":6,"language":"en","content_type":"Work","summary":"Articular cartilage is a thin layer covering the opposed bony faces, which aids in force absorption and acts as a low friction bearing for the two surfaces of the joint. Osteoarthritis results in a wearing away of this material which results in an increase in friction, stiffness, and pain. fully saturated natural cartilage contains 70-80 percent water. Hydrogels based on polyvinyl alcohol (PVA) have excellent biocompatibility and mechanical properties, however their maximum water absorption capacity is around 40%. The objective of this research was to investigate the effect of gamma radiation grafting of acrylic acid (AA) or N-vinyl pyrollidone (NVP) on water absorption, compression modulus, and biocompatibility of semicrystalline PVA hydrogel as an artificial carthage. PVA hydrogel was prepared as follows. A 10% w/w solution of PVA with greater than 99.4% saponification was prepared in distilled boiling water to allow complete dissolution. The solution was placed in an oven at 100掳C for 2 h in order for water to evaporate. The dried films were annealed in a vacuum oven at 120掳C for 1 h at 30 mmHg pressure to induce maximum crystallization of PVA. Samples were allowed to swell in distilled water for at least 48 h. After reaching equilibrium swelling, different amounts of purified AA or NV? ranging from 5 to 30% based on PVA was added to the aqueous solution, poured in a glass vial, purged with nitrogen, sealed with plastic top, and each vial was exposed to gamma radiation. After irradiation, the samples were washed twice with distilled water to remove uncrosslinked polymer and dried in vaccu at 40掳C for 12 h. The percent grafting was determined by measuring the weight of dry sample before and after irradiation. The percent swelling was determined by measuring the weight of swollen and dry sample in phosphate buffer solution with pH 7. for biocompatibility, Cell culture was performed using the ASTM-F813 standard procedure. Samples were sterilized by UV radiation and subsequent washing with ethanol and placed in sterilized peth dishes containing the culture medium at 37掳C. Antibacterial agents Penicillin G and Streptomycin were added to the petri dish in order to deactivate any remaining bacteria. Fibroblast cells, obtained from fran Pasture Institute, with concentration of 1 .3x105 cell/mi were added to each pen-i dish and placed in a CO, incubator at 37掳C for 24 h. After cell culture, the samples were washed with PBS buffer. The remaining cells on the surface after washing were fixed with gluteraldhyde and stained with trepan blue for microscopic observation. Ungrafted PVA had about 40% by weight water absorption. When PVA was grafted with 10%, 20% and 30% AA, water absorption increased to 45%, 50% and 55%. On the other hand, when PVA was grafted with 10%, 20%, and 30% NVP, water absorption increased to 65%, 72% and 78%. As the PVA was grafted with 10%, 20% and 30% AA, cell toxicity increased significantly such that no cell growth was observed on the sample with 30% grafted AA. On the other hand, as the PVA was grafted with 10%, 20%, and 30% NVP, cell compatibility increased significantly compared with ungrafted PVA. Also, the NVP grafted PVA samples also had higher compression modulus. Therefore, the results indicate that the NV? grafted PVA is more suitable for use as artificial cartilage compared to ungrafted PVA.","owner":{"id":66499940,"first_name":"Saeed","middle_initials":null,"last_name":"Karbasi","page_name":"SaeedKarbasi","domain_name":"mui","created_at":"2017-07-17T06:31:55.223-07:00","display_name":"Saeed Karbasi","url":"https://mui.academia.edu/SaeedKarbasi"},"attachments":[{"id":53973268,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973268/thumbnails/1.jpg","file_name":"Effect_Of_Grafting_N-Vinyl_Pyrollidone_o20170725-25623-nyov1u.pdf","download_url":"https://www.academia.edu/attachments/53973268/download_file","bulk_download_file_name":"Effect_Of_Grafting_N_Vinyl_Pyrollidone_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973268/Effect_Of_Grafting_N-Vinyl_Pyrollidone_o20170725-25623-nyov1u-libre.pdf?1500997978=\u0026response-content-disposition=attachment%3B+filename%3DEffect_Of_Grafting_N_Vinyl_Pyrollidone_o.pdf\u0026Expires=1743370487\u0026Signature=GETe~3Bq8Pu9l3C0m~TsbyJDNqYT~wV4mWFwEZp0i192BRqoL9AR8EI1tus2ie06UghvxB6WTLPZVauoZ4yYbYQswVZYdNAlHsC6E9qh8q0lCdZwjuFrBtMU04NdpbbEmxjMU~23UoZEcIgzaOU99u-XXExrsqFNU8yxs1jpc9eA-h-tyzeFhGwZ2qsFC1uwzXMY3wuRj5LG6XzRcb0KWAH8oUYNyAtMHz-yatDq6EoL5SUQ09PVE5zFJ8mk4hpjTrSsUowNGtGudFwDABZM84qM3FSp0VN5XXcfm2sxKjQdVi8CDfcLDCxCsMa1t26I-wvPHn9nxcEpeS9SHcgfbw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032111-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032110"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/34032110/A_Comparative_Study_of_Articular_Chondrocytes_Metabolism_on_a_Biodegradable_Polyesterurethane_Scaffold_and_Alginate_in_Different_Oxygen_Tension_and_pH"><img alt="Research paper thumbnail of A Comparative Study of Articular Chondrocytes Metabolism on a Biodegradable Polyesterurethane Scaffold and Alginate in Different Oxygen Tension and pH" class="work-thumbnail" src="https://attachments.academia-assets.com/53973270/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/34032110/A_Comparative_Study_of_Articular_Chondrocytes_Metabolism_on_a_Biodegradable_Polyesterurethane_Scaffold_and_Alginate_in_Different_Oxygen_Tension_and_pH">A Comparative Study of Articular Chondrocytes Metabolism on a Biodegradable Polyesterurethane Scaffold and Alginate in Different Oxygen Tension and pH</a></div><div class="wp-workCard_item"><span>IFMBE proceedings</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">There are some different methods in the literatures that used for healing and repairing of cartil...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">There are some different methods in the literatures that used for healing and repairing of cartilage. One of the methods for increasing of regeneration and metabolism in cartilage, is stimulating physicochemical parameters on cellpolymer systems, as cartilage based cells. In this research, two physicochemical parameters, oxygen tension and pH, was changed to measure the lactate production after 1, 2 and 3 days culture and GAG(glycosaminoglycan) production after 3, 7 and 14 days culture of chondrocytes on DegraPol庐, as a biodegradable polyurethane scaffold (BPUS), and alginate scaffolds. The results finally were compared on both scaffolds. The results showed that physicochemical parameters like oxygen tension and pH could change cell metabolism. In fact, the physicochemical parameters could affect lactate production and GAG content of chondrocyte cells and it does not depend on the type of scaffold. The best condition of the articular chondrocytes metabolism was for 5% O2 and pH=7.4(p<0.001). The comparison between BPUS and alginate scaffold is showing that the results are better for alginate beads (p<0.001). In fact, hydrophilicity of alginate causes better cell distribution and nutrition than BPUS; because the cells are able to transfer the ions and the products through the medium easily.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="745a8bf0c6aad45e2af5a36a157091a1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53973270,"asset_id":34032110,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53973270/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032110"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032110"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032110; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032110]").text(description); $(".js-view-count[data-work-id=34032110]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032110; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032110']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "745a8bf0c6aad45e2af5a36a157091a1" } } $('.js-work-strip[data-work-id=34032110]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032110,"title":"A Comparative Study of Articular Chondrocytes Metabolism on a Biodegradable Polyesterurethane Scaffold and Alginate in Different Oxygen Tension and pH","translated_title":"","metadata":{"grobid_abstract":"There are some different methods in the literatures that used for healing and repairing of cartilage. One of the methods for increasing of regeneration and metabolism in cartilage, is stimulating physicochemical parameters on cellpolymer systems, as cartilage based cells. In this research, two physicochemical parameters, oxygen tension and pH, was changed to measure the lactate production after 1, 2 and 3 days culture and GAG(glycosaminoglycan) production after 3, 7 and 14 days culture of chondrocytes on DegraPol庐, as a biodegradable polyurethane scaffold (BPUS), and alginate scaffolds. The results finally were compared on both scaffolds. The results showed that physicochemical parameters like oxygen tension and pH could change cell metabolism. In fact, the physicochemical parameters could affect lactate production and GAG content of chondrocyte cells and it does not depend on the type of scaffold. The best condition of the articular chondrocytes metabolism was for 5% O2 and pH=7.4(p\u003c0.001). The comparison between BPUS and alginate scaffold is showing that the results are better for alginate beads (p\u003c0.001). In fact, hydrophilicity of alginate causes better cell distribution and nutrition than BPUS; because the cells are able to transfer the ions and the products through the medium easily.","publication_name":"IFMBE proceedings","grobid_abstract_attachment_id":53973270},"translated_abstract":null,"internal_url":"https://www.academia.edu/34032110/A_Comparative_Study_of_Articular_Chondrocytes_Metabolism_on_a_Biodegradable_Polyesterurethane_Scaffold_and_Alginate_in_Different_Oxygen_Tension_and_pH","translated_internal_url":"","created_at":"2017-07-25T08:47:11.864-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":53973270,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973270/thumbnails/1.jpg","file_name":"A_Comparative_Study_of_Articular_Chondro20170725-25620-1e1vlg7.pdf","download_url":"https://www.academia.edu/attachments/53973270/download_file","bulk_download_file_name":"A_Comparative_Study_of_Articular_Chondro.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973270/A_Comparative_Study_of_Articular_Chondro20170725-25620-1e1vlg7-libre.pdf?1500997975=\u0026response-content-disposition=attachment%3B+filename%3DA_Comparative_Study_of_Articular_Chondro.pdf\u0026Expires=1743370487\u0026Signature=M1zLWnLNkvIhjFqLG3lQkQCftVx09IOSZ2sQSmpuHQKVcRjXqNvyL2SlibR0KudjkpxWQOjCuB0lQ2VJIQroF96kGOVdtQLyKpDr5RBLmrG5u3D7jgqBe1wHLrz~U0eoLF~Tutpw9RlnCb4vCLmWkuUcbb1ujp7nGoAWBC2FTf58VFN5e2waQT4vuuRJG5qmU95QPWLcDb0t9i7pTv-4U4o5ATTm5nh6Q2yFysPAapcr01SIXTssROe8Si39x71H~lE9zn2CwrpmLqVGUAmZCw~OsOZ1U86QRc4YfJgmgrIicjTVC2yzDugmWUvhfF68OhzIDXJ9KV3HSSlbJQ3wjQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_Comparative_Study_of_Articular_Chondrocytes_Metabolism_on_a_Biodegradable_Polyesterurethane_Scaffold_and_Alginate_in_Different_Oxygen_Tension_and_pH","translated_slug":"","page_count":4,"language":"en","content_type":"Work","summary":"There are some different methods in the literatures that used for healing and repairing of cartilage. One of the methods for increasing of regeneration and metabolism in cartilage, is stimulating physicochemical parameters on cellpolymer systems, as cartilage based cells. In this research, two physicochemical parameters, oxygen tension and pH, was changed to measure the lactate production after 1, 2 and 3 days culture and GAG(glycosaminoglycan) production after 3, 7 and 14 days culture of chondrocytes on DegraPol庐, as a biodegradable polyurethane scaffold (BPUS), and alginate scaffolds. The results finally were compared on both scaffolds. The results showed that physicochemical parameters like oxygen tension and pH could change cell metabolism. In fact, the physicochemical parameters could affect lactate production and GAG content of chondrocyte cells and it does not depend on the type of scaffold. The best condition of the articular chondrocytes metabolism was for 5% O2 and pH=7.4(p\u003c0.001). The comparison between BPUS and alginate scaffold is showing that the results are better for alginate beads (p\u003c0.001). In fact, hydrophilicity of alginate causes better cell distribution and nutrition than BPUS; because the cells are able to transfer the ions and the products through the medium easily.","owner":{"id":66499940,"first_name":"Saeed","middle_initials":null,"last_name":"Karbasi","page_name":"SaeedKarbasi","domain_name":"mui","created_at":"2017-07-17T06:31:55.223-07:00","display_name":"Saeed Karbasi","url":"https://mui.academia.edu/SaeedKarbasi"},"attachments":[{"id":53973270,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973270/thumbnails/1.jpg","file_name":"A_Comparative_Study_of_Articular_Chondro20170725-25620-1e1vlg7.pdf","download_url":"https://www.academia.edu/attachments/53973270/download_file","bulk_download_file_name":"A_Comparative_Study_of_Articular_Chondro.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973270/A_Comparative_Study_of_Articular_Chondro20170725-25620-1e1vlg7-libre.pdf?1500997975=\u0026response-content-disposition=attachment%3B+filename%3DA_Comparative_Study_of_Articular_Chondro.pdf\u0026Expires=1743370487\u0026Signature=M1zLWnLNkvIhjFqLG3lQkQCftVx09IOSZ2sQSmpuHQKVcRjXqNvyL2SlibR0KudjkpxWQOjCuB0lQ2VJIQroF96kGOVdtQLyKpDr5RBLmrG5u3D7jgqBe1wHLrz~U0eoLF~Tutpw9RlnCb4vCLmWkuUcbb1ujp7nGoAWBC2FTf58VFN5e2waQT4vuuRJG5qmU95QPWLcDb0t9i7pTv-4U4o5ATTm5nh6Q2yFysPAapcr01SIXTssROe8Si39x71H~lE9zn2CwrpmLqVGUAmZCw~OsOZ1U86QRc4YfJgmgrIicjTVC2yzDugmWUvhfF68OhzIDXJ9KV3HSSlbJQ3wjQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032110-figures'); } }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="7238883" id="papers"><div class="js-work-strip profile--work_container" data-work-id="34032129"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/34032129/Evaluation_of_Hydrostatic_Pressure_on_Metabolism_of_the_Articular_Chondrocytes_Seeded_on_Biodegradable_Polyurethane_as_Tissue_Engineering_Scaffold"><img alt="Research paper thumbnail of Evaluation of Hydrostatic Pressure on Metabolism of the Articular Chondrocytes Seeded on Biodegradable Polyurethane as Tissue Engineering Scaffold" class="work-thumbnail" src="https://attachments.academia-assets.com/53973274/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/34032129/Evaluation_of_Hydrostatic_Pressure_on_Metabolism_of_the_Articular_Chondrocytes_Seeded_on_Biodegradable_Polyurethane_as_Tissue_Engineering_Scaffold">Evaluation of Hydrostatic Pressure on Metabolism of the Articular Chondrocytes Seeded on Biodegradable Polyurethane as Tissue Engineering Scaffold</a></div><div class="wp-workCard_item"><span>Ifmbe Proceedings</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">One of the most effective parameters in articular cartilage tissue engineering is cell stimulatio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">One of the most effective parameters in articular cartilage tissue engineering is cell stimulation and growth. Using a reaction system which incorporates many of the same conditions as an articulating joint such as intermittent loading, long term culture and a suitable 3-D growth environment could stimulate chondrocytes metabolism. It has demonstrated that hydrostatic pressure, as a physicochemical parameter, also could increase chondrocytes metabolism in tissue constructs. In this research, the effect of hydrostatic pressure was investigated on lactate production and GAG (glycosaminoglycane) content produced by chondrocytes. The isolated chondrocytes, from animal joint, were seeded on a biodegradable polyesterurethane scaffold (BPUS) namely Degrapol 庐 and 4 MPa was applied to the samples for 4 h per day as a cyclic (1HZ, Sinusoidal) load. The results showed that in constant physicochemical conditions, the hydrostatic pressure could increase the amount of lactate, rate of lactate production and GAG as a significant cartilage metabolism on BPUS. In comparison to other biodegradable polymers, this research was showed that BPUS has great potential for articular cartilage tissue engineering, in vitro.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5a54675b1c8579ac8c8a68d909a68a8c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53973274,"asset_id":34032129,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53973274/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032129"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032129"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032129; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032129]").text(description); $(".js-view-count[data-work-id=34032129]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032129; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032129']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5a54675b1c8579ac8c8a68d909a68a8c" } } $('.js-work-strip[data-work-id=34032129]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032129,"title":"Evaluation of Hydrostatic Pressure on Metabolism of the Articular Chondrocytes Seeded on Biodegradable Polyurethane as Tissue Engineering Scaffold","translated_title":"","metadata":{"grobid_abstract":"One of the most effective parameters in articular cartilage tissue engineering is cell stimulation and growth. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032127-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032126"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/34032126/Evaluation_of_structural_and_mechanical_properties_of_electrospun_nano_micro_hybrid_of_poly_hydroxybutyrate_chitosan_silk_scaffold_for_cartilage_tissue_engineering"><img alt="Research paper thumbnail of Evaluation of structural and mechanical properties of electrospun nano-micro hybrid of poly hydroxybutyrate-chitosan/silk scaffold for cartilage tissue engineering" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Evaluation of structural and mechanical properties of electrospun nano-micro hybrid of poly hydroxybutyrate-chitosan/silk scaffold for cartilage tissue engineering</div><div class="wp-workCard_item"><span>Advanced Biomedical Research</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">One of the new methods of scaffold fabrication is a nano-micro hybrid structure in which the prop...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">One of the new methods of scaffold fabrication is a nano-micro hybrid structure in which the properties of the scaffold are improved by introducing nanometer and micrometer structures. This method could be suitable for scaffold designing if some features improve. In this study, electrospun nanofibers of 9% weight solution of poly (3-hydroxybutyrate) (P3HB) and a 15% weight of chitosan by trifluoroacetic acid were coated on both the surface of a silk knitted substrate in the optimum condition to improve the mechanical properties of scaffolds for cartilage tissue engineering application. These hybrid nano-micro fibrous scaffolds were characterized by structural and mechanical evaluation methods. Scanning electron microscopy values and porosity analysis showed that average diameter of nanofibers was 584.94 nm in electrospinning part and general porosity was more than 80%. Fourier transform infrared spectroscopy results indicated the presence of all elements without pollution. The tensile test also stated that by electrospinning, as well as adding chitosan, both maximum strength and maximum elongation increased to 187 N and 10 mm. It means that the microfibrous part of scaffold could affect mechanical properties of nano part of the hybrid scaffold, significantly. It could be concluded that P3HB-chitosan/silk hybrid scaffolds can be a good candidate for cartilage tissue engineering.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032126"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032126"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032126; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032126]").text(description); $(".js-view-count[data-work-id=34032126]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032126; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032126']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=34032126]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032126,"title":"Evaluation of structural and mechanical properties of electrospun nano-micro hybrid of poly hydroxybutyrate-chitosan/silk scaffold for cartilage tissue engineering","translated_title":"","metadata":{"abstract":"One of the new methods of scaffold fabrication is a nano-micro hybrid structure in which the properties of the scaffold are improved by introducing nanometer and micrometer structures. This method could be suitable for scaffold designing if some features improve. In this study, electrospun nanofibers of 9% weight solution of poly (3-hydroxybutyrate) (P3HB) and a 15% weight of chitosan by trifluoroacetic acid were coated on both the surface of a silk knitted substrate in the optimum condition to improve the mechanical properties of scaffolds for cartilage tissue engineering application. These hybrid nano-micro fibrous scaffolds were characterized by structural and mechanical evaluation methods. Scanning electron microscopy values and porosity analysis showed that average diameter of nanofibers was 584.94 nm in electrospinning part and general porosity was more than 80%. Fourier transform infrared spectroscopy results indicated the presence of all elements without pollution. The tensile test also stated that by electrospinning, as well as adding chitosan, both maximum strength and maximum elongation increased to 187 N and 10 mm. It means that the microfibrous part of scaffold could affect mechanical properties of nano part of the hybrid scaffold, significantly. It could be concluded that P3HB-chitosan/silk hybrid scaffolds can be a good candidate for cartilage tissue engineering.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Advanced Biomedical Research"},"translated_abstract":"One of the new methods of scaffold fabrication is a nano-micro hybrid structure in which the properties of the scaffold are improved by introducing nanometer and micrometer structures. This method could be suitable for scaffold designing if some features improve. In this study, electrospun nanofibers of 9% weight solution of poly (3-hydroxybutyrate) (P3HB) and a 15% weight of chitosan by trifluoroacetic acid were coated on both the surface of a silk knitted substrate in the optimum condition to improve the mechanical properties of scaffolds for cartilage tissue engineering application. These hybrid nano-micro fibrous scaffolds were characterized by structural and mechanical evaluation methods. Scanning electron microscopy values and porosity analysis showed that average diameter of nanofibers was 584.94 nm in electrospinning part and general porosity was more than 80%. Fourier transform infrared spectroscopy results indicated the presence of all elements without pollution. The tensile test also stated that by electrospinning, as well as adding chitosan, both maximum strength and maximum elongation increased to 187 N and 10 mm. It means that the microfibrous part of scaffold could affect mechanical properties of nano part of the hybrid scaffold, significantly. It could be concluded that P3HB-chitosan/silk hybrid scaffolds can be a good candidate for cartilage tissue engineering.","internal_url":"https://www.academia.edu/34032126/Evaluation_of_structural_and_mechanical_properties_of_electrospun_nano_micro_hybrid_of_poly_hydroxybutyrate_chitosan_silk_scaffold_for_cartilage_tissue_engineering","translated_internal_url":"","created_at":"2017-07-25T08:47:14.719-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Evaluation_of_structural_and_mechanical_properties_of_electrospun_nano_micro_hybrid_of_poly_hydroxybutyrate_chitosan_silk_scaffold_for_cartilage_tissue_engineering","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"One of the new methods of scaffold fabrication is a nano-micro hybrid structure in which the properties of the scaffold are improved by introducing nanometer and micrometer structures. This method could be suitable for scaffold designing if some features improve. In this study, electrospun nanofibers of 9% weight solution of poly (3-hydroxybutyrate) (P3HB) and a 15% weight of chitosan by trifluoroacetic acid were coated on both the surface of a silk knitted substrate in the optimum condition to improve the mechanical properties of scaffolds for cartilage tissue engineering application. These hybrid nano-micro fibrous scaffolds were characterized by structural and mechanical evaluation methods. Scanning electron microscopy values and porosity analysis showed that average diameter of nanofibers was 584.94 nm in electrospinning part and general porosity was more than 80%. Fourier transform infrared spectroscopy results indicated the presence of all elements without pollution. The tensile test also stated that by electrospinning, as well as adding chitosan, both maximum strength and maximum elongation increased to 187 N and 10 mm. It means that the microfibrous part of scaffold could affect mechanical properties of nano part of the hybrid scaffold, significantly. It could be concluded that P3HB-chitosan/silk hybrid scaffolds can be a good candidate for cartilage tissue engineering.","owner":{"id":66499940,"first_name":"Saeed","middle_initials":null,"last_name":"Karbasi","page_name":"SaeedKarbasi","domain_name":"mui","created_at":"2017-07-17T06:31:55.223-07:00","display_name":"Saeed Karbasi","url":"https://mui.academia.edu/SaeedKarbasi"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032126-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032125"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/34032125/Evaluate_the_growth_and_adhesion_of_osteoblast_cells_on_nanocomposite_scaffold_of_hydroxyapatite_titania_coated_with_poly_hydroxybutyrate"><img alt="Research paper thumbnail of Evaluate the growth and adhesion of osteoblast cells on nanocomposite scaffold of hydroxyapatite/titania coated with poly hydroxybutyrate" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Evaluate the growth and adhesion of osteoblast cells on nanocomposite scaffold of hydroxyapatite/titania coated with poly hydroxybutyrate</div><div class="wp-workCard_item"><span>Advanced Biomedical Research</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The generation of bioartificial bone tissues may help to overcome the problems related to donor s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The generation of bioartificial bone tissues may help to overcome the problems related to donor site morbidity and size limitations. In this paper, hydroxyapatite (HA) powder was made out of bovine bone by thermal analysis at 900掳C and first, and then, porous HA (50 weight percentage) was produced by polyurethane sponge replication method. In order to improve the scaffold mechanical properties, they have been coated with poly hydroxybutyrate. In terms of phase studies, morphology, and specifying agent groups, the specific characterization devices such as X-ray diffraction and Fourier transform infrared, were employed. To compare the behavior of cellular scaffolds, they were divided into four groups of scaffolds. The osteoblast cells were cultured. To perform phase studies, analysis of Methylthiazole tetrazolium (MTT) and Trypan blue were carried out for the viability and attachment on the surface of the scaffold, and the specification of Scanning electron microscopy was employed for the morphology of the cells. The results of MTT analysis performed on four groups of scaffolds have shown that Titanium oxide (Tio2) had no effect on cell growth alone and HA was the main factor of growth and cell osteoblast adhesion on the scaffold. Moreover, the results showed that the use of coating with poly-3-hydroxybutyrate saved the factors and placed the osteoblasts within the pore. Since the main part of bone consists of HA, the TiO2 accelerates the formation of apatite crystals at the scaffold surface which is the evidence for bone tissue regeneration. It is likely that the relation between HA and TiO2 leads to an increase in osteoblast adhesion and growth of cells on the scaffold surface.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032125"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032125"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032125; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032125]").text(description); $(".js-view-count[data-work-id=34032125]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032125; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032125']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=34032125]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032125,"title":"Evaluate the growth and adhesion of osteoblast cells on nanocomposite scaffold of hydroxyapatite/titania coated with poly hydroxybutyrate","translated_title":"","metadata":{"abstract":"The generation of bioartificial bone tissues may help to overcome the problems related to donor site morbidity and size limitations. In this paper, hydroxyapatite (HA) powder was made out of bovine bone by thermal analysis at 900掳C and first, and then, porous HA (50 weight percentage) was produced by polyurethane sponge replication method. In order to improve the scaffold mechanical properties, they have been coated with poly hydroxybutyrate. In terms of phase studies, morphology, and specifying agent groups, the specific characterization devices such as X-ray diffraction and Fourier transform infrared, were employed. To compare the behavior of cellular scaffolds, they were divided into four groups of scaffolds. The osteoblast cells were cultured. To perform phase studies, analysis of Methylthiazole tetrazolium (MTT) and Trypan blue were carried out for the viability and attachment on the surface of the scaffold, and the specification of Scanning electron microscopy was employed for the morphology of the cells. The results of MTT analysis performed on four groups of scaffolds have shown that Titanium oxide (Tio2) had no effect on cell growth alone and HA was the main factor of growth and cell osteoblast adhesion on the scaffold. Moreover, the results showed that the use of coating with poly-3-hydroxybutyrate saved the factors and placed the osteoblasts within the pore. Since the main part of bone consists of HA, the TiO2 accelerates the formation of apatite crystals at the scaffold surface which is the evidence for bone tissue regeneration. It is likely that the relation between HA and TiO2 leads to an increase in osteoblast adhesion and growth of cells on the scaffold surface.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Advanced Biomedical Research"},"translated_abstract":"The generation of bioartificial bone tissues may help to overcome the problems related to donor site morbidity and size limitations. In this paper, hydroxyapatite (HA) powder was made out of bovine bone by thermal analysis at 900掳C and first, and then, porous HA (50 weight percentage) was produced by polyurethane sponge replication method. In order to improve the scaffold mechanical properties, they have been coated with poly hydroxybutyrate. In terms of phase studies, morphology, and specifying agent groups, the specific characterization devices such as X-ray diffraction and Fourier transform infrared, were employed. To compare the behavior of cellular scaffolds, they were divided into four groups of scaffolds. The osteoblast cells were cultured. To perform phase studies, analysis of Methylthiazole tetrazolium (MTT) and Trypan blue were carried out for the viability and attachment on the surface of the scaffold, and the specification of Scanning electron microscopy was employed for the morphology of the cells. The results of MTT analysis performed on four groups of scaffolds have shown that Titanium oxide (Tio2) had no effect on cell growth alone and HA was the main factor of growth and cell osteoblast adhesion on the scaffold. Moreover, the results showed that the use of coating with poly-3-hydroxybutyrate saved the factors and placed the osteoblasts within the pore. Since the main part of bone consists of HA, the TiO2 accelerates the formation of apatite crystals at the scaffold surface which is the evidence for bone tissue regeneration. It is likely that the relation between HA and TiO2 leads to an increase in osteoblast adhesion and growth of cells on the scaffold surface.","internal_url":"https://www.academia.edu/34032125/Evaluate_the_growth_and_adhesion_of_osteoblast_cells_on_nanocomposite_scaffold_of_hydroxyapatite_titania_coated_with_poly_hydroxybutyrate","translated_internal_url":"","created_at":"2017-07-25T08:47:14.571-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Evaluate_the_growth_and_adhesion_of_osteoblast_cells_on_nanocomposite_scaffold_of_hydroxyapatite_titania_coated_with_poly_hydroxybutyrate","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The generation of bioartificial bone tissues may help to overcome the problems related to donor site morbidity and size limitations. In this paper, hydroxyapatite (HA) powder was made out of bovine bone by thermal analysis at 900掳C and first, and then, porous HA (50 weight percentage) was produced by polyurethane sponge replication method. In order to improve the scaffold mechanical properties, they have been coated with poly hydroxybutyrate. In terms of phase studies, morphology, and specifying agent groups, the specific characterization devices such as X-ray diffraction and Fourier transform infrared, were employed. To compare the behavior of cellular scaffolds, they were divided into four groups of scaffolds. The osteoblast cells were cultured. To perform phase studies, analysis of Methylthiazole tetrazolium (MTT) and Trypan blue were carried out for the viability and attachment on the surface of the scaffold, and the specification of Scanning electron microscopy was employed for the morphology of the cells. The results of MTT analysis performed on four groups of scaffolds have shown that Titanium oxide (Tio2) had no effect on cell growth alone and HA was the main factor of growth and cell osteoblast adhesion on the scaffold. Moreover, the results showed that the use of coating with poly-3-hydroxybutyrate saved the factors and placed the osteoblasts within the pore. Since the main part of bone consists of HA, the TiO2 accelerates the formation of apatite crystals at the scaffold surface which is the evidence for bone tissue regeneration. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032119-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032118"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/34032118/Influence_of_calcinated_and_non_calcinated_nanobioglass_particles_on_hardness_and_bioactivity_of_sol_gel_derived_TiO_2_SiO_2_nano_composite_coatings_on_stainless_steel_substrates"><img alt="Research paper thumbnail of Influence of calcinated and non calcinated nanobioglass particles on hardness and bioactivity of sol-gel-derived TiO 2 -SiO 2 nano composite coatings on stainless steel substrates" class="work-thumbnail" src="https://attachments.academia-assets.com/53973272/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/34032118/Influence_of_calcinated_and_non_calcinated_nanobioglass_particles_on_hardness_and_bioactivity_of_sol_gel_derived_TiO_2_SiO_2_nano_composite_coatings_on_stainless_steel_substrates">Influence of calcinated and non calcinated nanobioglass particles on hardness and bioactivity of sol-gel-derived TiO 2 -SiO 2 nano composite coatings on stainless steel substrates</a></div><div class="wp-workCard_item"><span>J Mater Sci Mater Med</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Thick films of calcinated and non calcinated nanobioglass (NBG)-titania composite coatings were p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Thick films of calcinated and non calcinated nanobioglass (NBG)-titania composite coatings were prepared on stainless steel substrates by alkoxide sol-gel process. Dip-coating method was used for the films preparation. The morphology, structure and composition of the nano composite films were evaluated using environmental scanning electron microscope, X-ray diffraction and Fourier transform infrared spectroscope. The SEM investigation results showed that prepared thick NBG-titania films are smooth and free of macrocracking, fracture or flaking. The grain size of these films was uniform and nano scale (50-60 nm) which confirmed with TEM. Also FTIR confirmed the presence of Si-O-Si bands on the calcinated NBG-titania films. The hardness of the prepared films (TiO 2 -calcinated NBG and TiO 2 -Non calcinated NBG) was compared by using micro hardness test method. The results verified that the presence of calcinated NBG particles in NBG-titania composite enhanced gradually the mechanical data of the prepared films. The in vitro bioactivity of these films was discussed based on the analysis of the variations of Ca and P concentrations in the simulated body fluid (SBF) and their surface morphologies against immersion time. Surface morphology and Si-O-Si bands were found to be of great importance with respect to the bioactivity of the studied films. The results showed that calcinated NBGtitania films have better bioactivity than non calcinated NBG-titania films.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a461cd2a8a6eea9610322a1981e05de" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53973272,"asset_id":34032118,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53973272/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032118"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032118"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032118; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032118]").text(description); $(".js-view-count[data-work-id=34032118]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032118; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032118']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8a461cd2a8a6eea9610322a1981e05de" } } $('.js-work-strip[data-work-id=34032118]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032118,"title":"Influence of calcinated and non calcinated nanobioglass particles on hardness and bioactivity of sol-gel-derived TiO 2 -SiO 2 nano composite coatings on stainless steel substrates","translated_title":"","metadata":{"grobid_abstract":"Thick films of calcinated and non calcinated nanobioglass (NBG)-titania composite coatings were prepared on stainless steel substrates by alkoxide sol-gel process. 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The in vitro bioactivity of these films was discussed based on the analysis of the variations of Ca and P concentrations in the simulated body fluid (SBF) and their surface morphologies against immersion time. Surface morphology and Si-O-Si bands were found to be of great importance with respect to the bioactivity of the studied films. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032118-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032117"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/34032117/Cell_Attachment_and_Proliferation_of_Human_Adipose_Derived_Stem_Cells_on_PLGA_Chitosan_Electrospun_Nano_Biocomposite"><img alt="Research paper thumbnail of Cell Attachment and Proliferation of Human Adipose-Derived Stem Cells on PLGA/Chitosan Electrospun Nano-Biocomposite" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Cell Attachment and Proliferation of Human Adipose-Derived Stem Cells on PLGA/Chitosan Electrospun Nano-Biocomposite</div><div class="wp-workCard_item"><span>Cell journal</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this study, nano-biocomposite composed of poly (lactide-co-glycolide) (PLGA) and chitosan (CS)...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this study, nano-biocomposite composed of poly (lactide-co-glycolide) (PLGA) and chitosan (CS) were electrospun through a single nozzle by dispersing the CS nano-powders in PLGA solution. The cellular behavior of human adipose derived stem cells (h-ADSCs) on random and aligned scaffolds was then evaluated. In this experimental study, the PLGA/CS scaffolds were prepared at the different ratios of 90/10, 80/20, and 70/30 (w/w) %. Morphology, cell adhesion and prolif- eration rate of h-ADSCs on the scaffolds were assessed using scanning electron microscope (SEM), 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and trypan blue staining respectively. H-ADSCs seeded on the matrices indicated that the PLGA/CS composite matrix with aligned nanofibres and higher content of CS nano-powders gave significantly better performance than others in terms of cell adhesion and proliferation rate (P&lt;0.05). We found that CS enhanced cell adhesion and proliferation rate,...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032117"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032117"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032117; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032117]").text(description); $(".js-view-count[data-work-id=34032117]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032117; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032117']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=34032117]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032117,"title":"Cell Attachment and Proliferation of Human Adipose-Derived Stem Cells on PLGA/Chitosan Electrospun Nano-Biocomposite","translated_title":"","metadata":{"abstract":"In this study, nano-biocomposite composed of poly (lactide-co-glycolide) (PLGA) and chitosan (CS) were electrospun through a single nozzle by dispersing the CS nano-powders in PLGA solution. The cellular behavior of human adipose derived stem cells (h-ADSCs) on random and aligned scaffolds was then evaluated. In this experimental study, the PLGA/CS scaffolds were prepared at the different ratios of 90/10, 80/20, and 70/30 (w/w) %. Morphology, cell adhesion and prolif- eration rate of h-ADSCs on the scaffolds were assessed using scanning electron microscope (SEM), 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and trypan blue staining respectively. H-ADSCs seeded on the matrices indicated that the PLGA/CS composite matrix with aligned nanofibres and higher content of CS nano-powders gave significantly better performance than others in terms of cell adhesion and proliferation rate (P\u0026lt;0.05). We found that CS enhanced cell adhesion and proliferation rate,...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Cell journal"},"translated_abstract":"In this study, nano-biocomposite composed of poly (lactide-co-glycolide) (PLGA) and chitosan (CS) were electrospun through a single nozzle by dispersing the CS nano-powders in PLGA solution. The cellular behavior of human adipose derived stem cells (h-ADSCs) on random and aligned scaffolds was then evaluated. In this experimental study, the PLGA/CS scaffolds were prepared at the different ratios of 90/10, 80/20, and 70/30 (w/w) %. Morphology, cell adhesion and prolif- eration rate of h-ADSCs on the scaffolds were assessed using scanning electron microscope (SEM), 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and trypan blue staining respectively. H-ADSCs seeded on the matrices indicated that the PLGA/CS composite matrix with aligned nanofibres and higher content of CS nano-powders gave significantly better performance than others in terms of cell adhesion and proliferation rate (P\u0026lt;0.05). We found that CS enhanced cell adhesion and proliferation rate,...","internal_url":"https://www.academia.edu/34032117/Cell_Attachment_and_Proliferation_of_Human_Adipose_Derived_Stem_Cells_on_PLGA_Chitosan_Electrospun_Nano_Biocomposite","translated_internal_url":"","created_at":"2017-07-25T08:47:13.180-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Cell_Attachment_and_Proliferation_of_Human_Adipose_Derived_Stem_Cells_on_PLGA_Chitosan_Electrospun_Nano_Biocomposite","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"In this study, nano-biocomposite composed of poly (lactide-co-glycolide) (PLGA) and chitosan (CS) were electrospun through a single nozzle by dispersing the CS nano-powders in PLGA solution. The cellular behavior of human adipose derived stem cells (h-ADSCs) on random and aligned scaffolds was then evaluated. In this experimental study, the PLGA/CS scaffolds were prepared at the different ratios of 90/10, 80/20, and 70/30 (w/w) %. Morphology, cell adhesion and prolif- eration rate of h-ADSCs on the scaffolds were assessed using scanning electron microscope (SEM), 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and trypan blue staining respectively. H-ADSCs seeded on the matrices indicated that the PLGA/CS composite matrix with aligned nanofibres and higher content of CS nano-powders gave significantly better performance than others in terms of cell adhesion and proliferation rate (P\u0026lt;0.05). We found that CS enhanced cell adhesion and proliferation rate,...","owner":{"id":66499940,"first_name":"Saeed","middle_initials":null,"last_name":"Karbasi","page_name":"SaeedKarbasi","domain_name":"mui","created_at":"2017-07-17T06:31:55.223-07:00","display_name":"Saeed Karbasi","url":"https://mui.academia.edu/SaeedKarbasi"},"attachments":[],"research_interests":[{"id":107533,"name":"Cell","url":"https://www.academia.edu/Documents/in/Cell"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032117-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032116"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/34032116/Novel_sol_gel_synthesis_and_characterization_of_nanostructured_hydroxyapatite_powder"><img alt="Research paper thumbnail of Novel sol鈥揼el synthesis and characterization of nanostructured hydroxyapatite powder" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Novel sol鈥揼el synthesis and characterization of nanostructured hydroxyapatite powder</div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Nanocrystalline powders of hydroxyapatite (HA) were prepared from Ca (NO 3) 2路 4H 2 O and P 2 O 5...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Nanocrystalline powders of hydroxyapatite (HA) were prepared from Ca (NO 3) 2路 4H 2 O and P 2 O 5 using a simple sol聳gel approach. The resultant gel precursors obtained based on the concentration of the starting solutions were either transparent or translucent. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032116"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032116"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032116; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032116]").text(description); $(".js-view-count[data-work-id=34032116]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032116; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032116']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=34032116]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032116,"title":"Novel sol鈥揼el synthesis and characterization of nanostructured hydroxyapatite powder","translated_title":"","metadata":{"abstract":"Nanocrystalline powders of hydroxyapatite (HA) were prepared from Ca (NO 3) 2路 4H 2 O and P 2 O 5 using a simple sol聳gel approach. The resultant gel precursors obtained based on the concentration of the starting solutions were either transparent or translucent. ...","publication_date":{"day":null,"month":null,"year":2010,"errors":{}}},"translated_abstract":"Nanocrystalline powders of hydroxyapatite (HA) were prepared from Ca (NO 3) 2路 4H 2 O and P 2 O 5 using a simple sol聳gel approach. The resultant gel precursors obtained based on the concentration of the starting solutions were either transparent or translucent. ...","internal_url":"https://www.academia.edu/34032116/Novel_sol_gel_synthesis_and_characterization_of_nanostructured_hydroxyapatite_powder","translated_internal_url":"","created_at":"2017-07-25T08:47:13.032-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Novel_sol_gel_synthesis_and_characterization_of_nanostructured_hydroxyapatite_powder","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Nanocrystalline powders of hydroxyapatite (HA) were prepared from Ca (NO 3) 2路 4H 2 O and P 2 O 5 using a simple sol聳gel approach. The resultant gel precursors obtained based on the concentration of the starting solutions were either transparent or translucent. ...","owner":{"id":66499940,"first_name":"Saeed","middle_initials":null,"last_name":"Karbasi","page_name":"SaeedKarbasi","domain_name":"mui","created_at":"2017-07-17T06:31:55.223-07:00","display_name":"Saeed Karbasi","url":"https://mui.academia.edu/SaeedKarbasi"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032116-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032115"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/34032115/Physical_and_mechanical_properties_of_a_poly_3_hydroxybutyratecoated_nanocrystalline_Bioglass_45S5_scaffold_for_bone_tissue_engineering"><img alt="Research paper thumbnail of Physical and mechanical properties of a poly-3-hydroxybutyratecoated nanocrystalline Bioglass 45S5 scaffold for bone tissue engineering" class="work-thumbnail" src="https://attachments.academia-assets.com/53973269/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/34032115/Physical_and_mechanical_properties_of_a_poly_3_hydroxybutyratecoated_nanocrystalline_Bioglass_45S5_scaffold_for_bone_tissue_engineering">Physical and mechanical properties of a poly-3-hydroxybutyratecoated nanocrystalline Bioglass 45S5 scaffold for bone tissue engineering</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A major challenge for tissue engineers is the design of scaffolds with appropriate physical and m...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A major challenge for tissue engineers is the design of scaffolds with appropriate physical and mechanical properties. The present research discusses the formation of ceramic scaffolding in tissue engineering. Hydroxyapatite (HAp) powder was made from bovine bone by thermal treatment at 900掳C; 40, 50 and 60%wt porous HAp was then produced using the polyurethane sponge replication method. Scaffolds were coated with poly-3hydroxybutyrate (P3HB) for 30 s and 1 min in order to increase the scaffold's mechanical properties. XRD, SEM and FT-IR were used to study phase structure, morphology and agent groups, respectively. In XRD and FT-IR data, established hydrogen bands between polymer and ceramic matrix confirm that the scaffold is formed as a composite. The scaffold obtained with 50%wt HAp and a 30 s coating was 90% porous, with an average diameter of 100-400 lm, and demonstrated a compressive strength and modulus of 1.46 and 21.27 MPa, respectively. Based on these results, this scaffold is optimised for the aforementioned properties and can be utilised in bone tissue engineering.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6ba86ac54912fd16cb94a3efc5fd2933" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53973269,"asset_id":34032115,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53973269/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032115"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032115"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032115; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032115]").text(description); $(".js-view-count[data-work-id=34032115]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032115; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032115']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6ba86ac54912fd16cb94a3efc5fd2933" } } $('.js-work-strip[data-work-id=34032115]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032115,"title":"Physical and mechanical properties of a poly-3-hydroxybutyratecoated nanocrystalline Bioglass 45S5 scaffold for bone tissue engineering","translated_title":"","metadata":{"grobid_abstract":"A major challenge for tissue engineers is the design of scaffolds with appropriate physical and mechanical properties. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032115-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032114"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/34032114/Optimization_of_silk_yarn_hierarchical_structure_by_genetic_algorithm_to_design_scaffolds"><img alt="Research paper thumbnail of Optimization of silk yarn hierarchical structure by genetic algorithm to design scaffolds" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Optimization of silk yarn hierarchical structure by genetic algorithm to design scaffolds</div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://mui.academia.edu/SaeedKarbasi">Saeed Karbasi</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://iut.academia.edu/DariushSemnani">Dariush Semnani</a></span></div><div class="wp-workCard_item"><span>Indian Journal of Fibre Textile Research</span><span>, Mar 27, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032114"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032114"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032114; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032114-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032113"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/34032113/A_Comparison_between_Cell_Viability_of_Chondrocytes_on_a_Biodegradable_Polyester_Urethane_Scaffold_and_Alginate_Beads_in_Different_Oxygen_Tension_and_pH"><img alt="Research paper thumbnail of A Comparison between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and pH" class="work-thumbnail" src="https://attachments.academia-assets.com/53973282/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/34032113/A_Comparison_between_Cell_Viability_of_Chondrocytes_on_a_Biodegradable_Polyester_Urethane_Scaffold_and_Alginate_Beads_in_Different_Oxygen_Tension_and_pH">A Comparison between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and pH</a></div><div class="wp-workCard_item"><span>Iranian Polymer Journal</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">C artilage is a tissue that has a low potential for self-repair. One of the methods for improveme...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">C artilage is a tissue that has a low potential for self-repair. One of the methods for improvement of regeneration and metabolism in cartilge, is to stimulate physical factors on chondrocytes as cartilage based cells. In this research, two physical factors, oxygen tension and pH, were changed to measure the cell viability of chondrocytes on Degrapol庐, as a biodegradable polyurethane (DBS), and alginate scaffolds and cell viability onto these substrates are compared. The results showed that, physical factors like oxygen and pH could change cell viability. After 3 days cell culture for both types of scaffolds, the cell viability was higher with 5% O 2 and pH=7.4 and it was not dependent on the type of scaffolds. Our results showed that cell viability on alginate beads is more than DBS scaffold for different conditions. chondrocyte; physical environment; Biodegradation; polyester urethane (Degrapol庐); alginate; cell viability.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="58f9470732d7ba3d65b84707973540a8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53973282,"asset_id":34032113,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53973282/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032113"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032113"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032113; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032113]").text(description); $(".js-view-count[data-work-id=34032113]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032113; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032113']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "58f9470732d7ba3d65b84707973540a8" } } $('.js-work-strip[data-work-id=34032113]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032113,"title":"A Comparison between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and pH","translated_title":"","metadata":{"ai_title_tag":"Chondrocyte Viability in Biodegradable Scaffolds","grobid_abstract":"C artilage is a tissue that has a low potential for self-repair. One of the methods for improvement of regeneration and metabolism in cartilge, is to stimulate physical factors on chondrocytes as cartilage based cells. In this research, two physical factors, oxygen tension and pH, were changed to measure the cell viability of chondrocytes on Degrapol庐, as a biodegradable polyurethane (DBS), and alginate scaffolds and cell viability onto these substrates are compared. The results showed that, physical factors like oxygen and pH could change cell viability. After 3 days cell culture for both types of scaffolds, the cell viability was higher with 5% O 2 and pH=7.4 and it was not dependent on the type of scaffolds. Our results showed that cell viability on alginate beads is more than DBS scaffold for different conditions. chondrocyte; physical environment; Biodegradation; polyester urethane (Degrapol庐); alginate; cell viability.","publication_name":"Iranian Polymer Journal","grobid_abstract_attachment_id":53973282},"translated_abstract":null,"internal_url":"https://www.academia.edu/34032113/A_Comparison_between_Cell_Viability_of_Chondrocytes_on_a_Biodegradable_Polyester_Urethane_Scaffold_and_Alginate_Beads_in_Different_Oxygen_Tension_and_pH","translated_internal_url":"","created_at":"2017-07-25T08:47:12.491-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":29854075,"work_id":34032113,"tagging_user_id":66499940,"tagged_user_id":38385151,"co_author_invite_id":null,"email":"j***n@dpag.ox.ac.uk","display_order":0,"name":"J. Urban","title":"A Comparison between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and pH"},{"id":29854076,"work_id":34032113,"tagging_user_id":66499940,"tagged_user_id":260764066,"co_author_invite_id":696639,"email":"m***h@aut.ac.ir","display_order":4194304,"name":"Hamid Mirzadeh","title":"A Comparison between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and pH"},{"id":29854077,"work_id":34032113,"tagging_user_id":66499940,"tagged_user_id":null,"co_author_invite_id":6452192,"email":"s***4@aut.ac.ir","display_order":6291456,"name":"Fariba Orang","title":"A Comparison between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and pH"}],"downloadable_attachments":[{"id":53973282,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973282/thumbnails/1.jpg","file_name":"81320050908.pdf","download_url":"https://www.academia.edu/attachments/53973282/download_file","bulk_download_file_name":"A_Comparison_between_Cell_Viability_of_C.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973282/81320050908-libre.pdf?1500998105=\u0026response-content-disposition=attachment%3B+filename%3DA_Comparison_between_Cell_Viability_of_C.pdf\u0026Expires=1743370487\u0026Signature=SYbIoRSClaxZBI2-rjWL1QKub72kzOHM4rywVbKXYrRCRQ14jIAmTBq4YBAFhOhzlER2TONzzmMMC9KwEq8OBSilawpLF2ao~AkDCpNAURezF-kAkRzJyIgb~0JqF9Kbel70d8PtMrop5PacuhO5MdWvUkp7bHOe3rei8j-nM2QOuRovnEj0CA1G5nfjjx4jn-0HQnC7~-91f6GFGsl-8CzY4aFxAbEvmSL3O80tdrpFZRFlIWCHzlkoCoFx5oTw7Y1s~DnmF0jOiCh4sRWDMEcqGgx8ObxCXOX7o12iBOm351P1Oq7KCQ9FznAxrJc9Tmm-ZrVoj-cxVIyktIKt4Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_Comparison_between_Cell_Viability_of_Chondrocytes_on_a_Biodegradable_Polyester_Urethane_Scaffold_and_Alginate_Beads_in_Different_Oxygen_Tension_and_pH","translated_slug":"","page_count":8,"language":"en","content_type":"Work","summary":"C artilage is a tissue that has a low potential for self-repair. One of the methods for improvement of regeneration and metabolism in cartilge, is to stimulate physical factors on chondrocytes as cartilage based cells. In this research, two physical factors, oxygen tension and pH, were changed to measure the cell viability of chondrocytes on Degrapol庐, as a biodegradable polyurethane (DBS), and alginate scaffolds and cell viability onto these substrates are compared. The results showed that, physical factors like oxygen and pH could change cell viability. After 3 days cell culture for both types of scaffolds, the cell viability was higher with 5% O 2 and pH=7.4 and it was not dependent on the type of scaffolds. Our results showed that cell viability on alginate beads is more than DBS scaffold for different conditions. chondrocyte; physical environment; Biodegradation; polyester urethane (Degrapol庐); alginate; cell viability.","owner":{"id":66499940,"first_name":"Saeed","middle_initials":null,"last_name":"Karbasi","page_name":"SaeedKarbasi","domain_name":"mui","created_at":"2017-07-17T06:31:55.223-07:00","display_name":"Saeed Karbasi","url":"https://mui.academia.edu/SaeedKarbasi"},"attachments":[{"id":53973282,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973282/thumbnails/1.jpg","file_name":"81320050908.pdf","download_url":"https://www.academia.edu/attachments/53973282/download_file","bulk_download_file_name":"A_Comparison_between_Cell_Viability_of_C.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973282/81320050908-libre.pdf?1500998105=\u0026response-content-disposition=attachment%3B+filename%3DA_Comparison_between_Cell_Viability_of_C.pdf\u0026Expires=1743370487\u0026Signature=SYbIoRSClaxZBI2-rjWL1QKub72kzOHM4rywVbKXYrRCRQ14jIAmTBq4YBAFhOhzlER2TONzzmMMC9KwEq8OBSilawpLF2ao~AkDCpNAURezF-kAkRzJyIgb~0JqF9Kbel70d8PtMrop5PacuhO5MdWvUkp7bHOe3rei8j-nM2QOuRovnEj0CA1G5nfjjx4jn-0HQnC7~-91f6GFGsl-8CzY4aFxAbEvmSL3O80tdrpFZRFlIWCHzlkoCoFx5oTw7Y1s~DnmF0jOiCh4sRWDMEcqGgx8ObxCXOX7o12iBOm351P1Oq7KCQ9FznAxrJc9Tmm-ZrVoj-cxVIyktIKt4Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":165002,"name":"Cell Viability","url":"https://www.academia.edu/Documents/in/Cell_Viability"},{"id":575534,"name":"Physical Environment","url":"https://www.academia.edu/Documents/in/Physical_Environment"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032113-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032112"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/34032112/Evaluation_of_the_Effects_of_Hydrostatic_Pressure_on_Metabolism_of_the_Articular_Chondrocytes_Seeded_on_Biodegradable_Polyurethane_as_Tissue_Engineering_Scaffold"><img alt="Research paper thumbnail of Evaluation of the Effects of Hydrostatic Pressure on Metabolism of the Articular Chondrocytes Seeded on Biodegradable Polyurethane as Tissue Engineering Scaffold" class="work-thumbnail" src="https://attachments.academia-assets.com/53973267/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/34032112/Evaluation_of_the_Effects_of_Hydrostatic_Pressure_on_Metabolism_of_the_Articular_Chondrocytes_Seeded_on_Biodegradable_Polyurethane_as_Tissue_Engineering_Scaffold">Evaluation of the Effects of Hydrostatic Pressure on Metabolism of the Articular Chondrocytes Seeded on Biodegradable Polyurethane as Tissue Engineering Scaffold</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">One of the most effective parameters in articular cartilage tissue engineering is cell stimulatio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">One of the most effective parameters in articular cartilage tissue engineering is cell stimulation and growth. Using a reaction system, which incorporates many of the same conditions as an articulating joint such as intermittent loading, long term culture and a suitable 3-D growth environment could stimulate chondrocytes metabolism. It has been demonstrated that hydrostatic pressure, as a physicochemical parameter, also could increase chondrocytes metabolism in tissue constructs. In this research, the effect of hydrostatic pressure was investigated on lactate production and GAG (glycosaminoglycan) content produced by chondrocytes. The isolated chondrocytes from animal joint, were seeded on a biodegradable polyesterurethane scaffold (BPUS) namely DegraPol 庐 and then, 4 MPa was applied to the samples for 4 hours per day as a cyclic (1 HZ, Sinusoidal) load. The results showed that in constant physicochemical conditions, the hydrostatic pressure could increase the amount of lactate (P<0.001), rate of lactate production (P<0.001) and GAG (P<0.01) as a significant cartilage metabolism on BPUS. In comparison to other biodegradable polymers, this research was showed that BPUS has great potential for articular cartilage tissue engineering, in vitro.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="136a89eddb647ea46c8f5cf96d96faac" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53973267,"asset_id":34032112,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53973267/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032112"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032112"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032112; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032112]").text(description); $(".js-view-count[data-work-id=34032112]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032112; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032112']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "136a89eddb647ea46c8f5cf96d96faac" } } $('.js-work-strip[data-work-id=34032112]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032112,"title":"Evaluation of the Effects of Hydrostatic Pressure on Metabolism of the Articular Chondrocytes Seeded on Biodegradable Polyurethane as Tissue Engineering Scaffold","translated_title":"","metadata":{"grobid_abstract":"One of the most effective parameters in articular cartilage tissue engineering is cell stimulation and growth. Using a reaction system, which incorporates many of the same conditions as an articulating joint such as intermittent loading, long term culture and a suitable 3-D growth environment could stimulate chondrocytes metabolism. It has been demonstrated that hydrostatic pressure, as a physicochemical parameter, also could increase chondrocytes metabolism in tissue constructs. In this research, the effect of hydrostatic pressure was investigated on lactate production and GAG (glycosaminoglycan) content produced by chondrocytes. The isolated chondrocytes from animal joint, were seeded on a biodegradable polyesterurethane scaffold (BPUS) namely DegraPol 庐 and then, 4 MPa was applied to the samples for 4 hours per day as a cyclic (1 HZ, Sinusoidal) load. The results showed that in constant physicochemical conditions, the hydrostatic pressure could increase the amount of lactate (P\u003c0.001), rate of lactate production (P\u003c0.001) and GAG (P\u003c0.01) as a significant cartilage metabolism on BPUS. In comparison to other biodegradable polymers, this research was showed that BPUS has great potential for articular cartilage tissue engineering, in vitro.","grobid_abstract_attachment_id":53973267},"translated_abstract":null,"internal_url":"https://www.academia.edu/34032112/Evaluation_of_the_Effects_of_Hydrostatic_Pressure_on_Metabolism_of_the_Articular_Chondrocytes_Seeded_on_Biodegradable_Polyurethane_as_Tissue_Engineering_Scaffold","translated_internal_url":"","created_at":"2017-07-25T08:47:12.328-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":53973267,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973267/thumbnails/1.jpg","file_name":"Evaluation_of_the_Effects_of_Hydrostatic20170725-25623-tdal2r.pdf","download_url":"https://www.academia.edu/attachments/53973267/download_file","bulk_download_file_name":"Evaluation_of_the_Effects_of_Hydrostatic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973267/Evaluation_of_the_Effects_of_Hydrostatic20170725-25623-tdal2r-libre.pdf?1500997983=\u0026response-content-disposition=attachment%3B+filename%3DEvaluation_of_the_Effects_of_Hydrostatic.pdf\u0026Expires=1743370487\u0026Signature=gdyTNDLqSMGyA9tT~v0D4Ft~YFk2twGxVWyITHLPTHO994Gnz7RAsiBuzkx8YUmNJ7cUswqQ0yren1JdYXMDyxIaqdqUic8~eOMYOKanX785AUghnS7FooxsVk7GIJTcziwZyIQTrLhzrfxyTkF0Z0xVrfk6zGUMczkCourc~JTPmurP~MboLhNuxMz6Y~LWzDF5ryKIOFPoze2SmIxC3~dCt-n8Wrwl-jjzFNmsUTHWPPKK5MRJGO4FHnm29QhRtbJkBiC0oQ2m7VnPVsncVVte4NambRmt4IlAkKPWGcyyYJYdQUOjgbnPoOAzO1oAfBC5cIi6hlfgcsUQ52IXPg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Evaluation_of_the_Effects_of_Hydrostatic_Pressure_on_Metabolism_of_the_Articular_Chondrocytes_Seeded_on_Biodegradable_Polyurethane_as_Tissue_Engineering_Scaffold","translated_slug":"","page_count":8,"language":"en","content_type":"Work","summary":"One of the most effective parameters in articular cartilage tissue engineering is cell stimulation and growth. Using a reaction system, which incorporates many of the same conditions as an articulating joint such as intermittent loading, long term culture and a suitable 3-D growth environment could stimulate chondrocytes metabolism. It has been demonstrated that hydrostatic pressure, as a physicochemical parameter, also could increase chondrocytes metabolism in tissue constructs. In this research, the effect of hydrostatic pressure was investigated on lactate production and GAG (glycosaminoglycan) content produced by chondrocytes. The isolated chondrocytes from animal joint, were seeded on a biodegradable polyesterurethane scaffold (BPUS) namely DegraPol 庐 and then, 4 MPa was applied to the samples for 4 hours per day as a cyclic (1 HZ, Sinusoidal) load. The results showed that in constant physicochemical conditions, the hydrostatic pressure could increase the amount of lactate (P\u003c0.001), rate of lactate production (P\u003c0.001) and GAG (P\u003c0.01) as a significant cartilage metabolism on BPUS. In comparison to other biodegradable polymers, this research was showed that BPUS has great potential for articular cartilage tissue engineering, in vitro.","owner":{"id":66499940,"first_name":"Saeed","middle_initials":null,"last_name":"Karbasi","page_name":"SaeedKarbasi","domain_name":"mui","created_at":"2017-07-17T06:31:55.223-07:00","display_name":"Saeed Karbasi","url":"https://mui.academia.edu/SaeedKarbasi"},"attachments":[{"id":53973267,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973267/thumbnails/1.jpg","file_name":"Evaluation_of_the_Effects_of_Hydrostatic20170725-25623-tdal2r.pdf","download_url":"https://www.academia.edu/attachments/53973267/download_file","bulk_download_file_name":"Evaluation_of_the_Effects_of_Hydrostatic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973267/Evaluation_of_the_Effects_of_Hydrostatic20170725-25623-tdal2r-libre.pdf?1500997983=\u0026response-content-disposition=attachment%3B+filename%3DEvaluation_of_the_Effects_of_Hydrostatic.pdf\u0026Expires=1743370487\u0026Signature=gdyTNDLqSMGyA9tT~v0D4Ft~YFk2twGxVWyITHLPTHO994Gnz7RAsiBuzkx8YUmNJ7cUswqQ0yren1JdYXMDyxIaqdqUic8~eOMYOKanX785AUghnS7FooxsVk7GIJTcziwZyIQTrLhzrfxyTkF0Z0xVrfk6zGUMczkCourc~JTPmurP~MboLhNuxMz6Y~LWzDF5ryKIOFPoze2SmIxC3~dCt-n8Wrwl-jjzFNmsUTHWPPKK5MRJGO4FHnm29QhRtbJkBiC0oQ2m7VnPVsncVVte4NambRmt4IlAkKPWGcyyYJYdQUOjgbnPoOAzO1oAfBC5cIi6hlfgcsUQ52IXPg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032112-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032111"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/34032111/Effect_Of_Grafting_N_Vinyl_Pyrollidone_or_Acrylic_Acid_on_Cytotoxicity_Water_Absorption_and_Compression_Modulus_of_Crosslinked_Polyvinyl_Alcohol_as_Artificial_Cartilage"><img alt="Research paper thumbnail of Effect Of Grafting N-Vinyl Pyrollidone or Acrylic Acid on Cytotoxicity, Water Absorption, and Compression Modulus of Crosslinked Polyvinyl Alcohol as Artificial Cartilage" class="work-thumbnail" src="https://attachments.academia-assets.com/53973268/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/34032111/Effect_Of_Grafting_N_Vinyl_Pyrollidone_or_Acrylic_Acid_on_Cytotoxicity_Water_Absorption_and_Compression_Modulus_of_Crosslinked_Polyvinyl_Alcohol_as_Artificial_Cartilage">Effect Of Grafting N-Vinyl Pyrollidone or Acrylic Acid on Cytotoxicity, Water Absorption, and Compression Modulus of Crosslinked Polyvinyl Alcohol as Artificial Cartilage</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Articular cartilage is a thin layer covering the opposed bony faces, which aids in force absorpti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Articular cartilage is a thin layer covering the opposed bony faces, which aids in force absorption and acts as a low friction bearing for the two surfaces of the joint. Osteoarthritis results in a wearing away of this material which results in an increase in friction, stiffness, and pain. fully saturated natural cartilage contains 70-80 percent water. Hydrogels based on polyvinyl alcohol (PVA) have excellent biocompatibility and mechanical properties, however their maximum water absorption capacity is around 40%. The objective of this research was to investigate the effect of gamma radiation grafting of acrylic acid (AA) or N-vinyl pyrollidone (NVP) on water absorption, compression modulus, and biocompatibility of semicrystalline PVA hydrogel as an artificial carthage. PVA hydrogel was prepared as follows. A 10% w/w solution of PVA with greater than 99.4% saponification was prepared in distilled boiling water to allow complete dissolution. The solution was placed in an oven at 100掳C for 2 h in order for water to evaporate. The dried films were annealed in a vacuum oven at 120掳C for 1 h at 30 mmHg pressure to induce maximum crystallization of PVA. Samples were allowed to swell in distilled water for at least 48 h. After reaching equilibrium swelling, different amounts of purified AA or NV? ranging from 5 to 30% based on PVA was added to the aqueous solution, poured in a glass vial, purged with nitrogen, sealed with plastic top, and each vial was exposed to gamma radiation. After irradiation, the samples were washed twice with distilled water to remove uncrosslinked polymer and dried in vaccu at 40掳C for 12 h. The percent grafting was determined by measuring the weight of dry sample before and after irradiation. The percent swelling was determined by measuring the weight of swollen and dry sample in phosphate buffer solution with pH 7. for biocompatibility, Cell culture was performed using the ASTM-F813 standard procedure. Samples were sterilized by UV radiation and subsequent washing with ethanol and placed in sterilized peth dishes containing the culture medium at 37掳C. Antibacterial agents Penicillin G and Streptomycin were added to the petri dish in order to deactivate any remaining bacteria. Fibroblast cells, obtained from fran Pasture Institute, with concentration of 1 .3x105 cell/mi were added to each pen-i dish and placed in a CO, incubator at 37掳C for 24 h. After cell culture, the samples were washed with PBS buffer. The remaining cells on the surface after washing were fixed with gluteraldhyde and stained with trepan blue for microscopic observation. Ungrafted PVA had about 40% by weight water absorption. When PVA was grafted with 10%, 20% and 30% AA, water absorption increased to 45%, 50% and 55%. On the other hand, when PVA was grafted with 10%, 20%, and 30% NVP, water absorption increased to 65%, 72% and 78%. As the PVA was grafted with 10%, 20% and 30% AA, cell toxicity increased significantly such that no cell growth was observed on the sample with 30% grafted AA. On the other hand, as the PVA was grafted with 10%, 20%, and 30% NVP, cell compatibility increased significantly compared with ungrafted PVA. Also, the NVP grafted PVA samples also had higher compression modulus. Therefore, the results indicate that the NV? grafted PVA is more suitable for use as artificial cartilage compared to ungrafted PVA.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4494d1f11c289886a85714bab0477e1c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53973268,"asset_id":34032111,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53973268/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032111"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032111"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032111; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032111]").text(description); $(".js-view-count[data-work-id=34032111]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032111; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032111']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4494d1f11c289886a85714bab0477e1c" } } $('.js-work-strip[data-work-id=34032111]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032111,"title":"Effect Of Grafting N-Vinyl Pyrollidone or Acrylic Acid on Cytotoxicity, Water Absorption, and Compression Modulus of Crosslinked Polyvinyl Alcohol as Artificial Cartilage","translated_title":"","metadata":{"grobid_abstract":"Articular cartilage is a thin layer covering the opposed bony faces, which aids in force absorption and acts as a low friction bearing for the two surfaces of the joint. Osteoarthritis results in a wearing away of this material which results in an increase in friction, stiffness, and pain. fully saturated natural cartilage contains 70-80 percent water. Hydrogels based on polyvinyl alcohol (PVA) have excellent biocompatibility and mechanical properties, however their maximum water absorption capacity is around 40%. The objective of this research was to investigate the effect of gamma radiation grafting of acrylic acid (AA) or N-vinyl pyrollidone (NVP) on water absorption, compression modulus, and biocompatibility of semicrystalline PVA hydrogel as an artificial carthage. PVA hydrogel was prepared as follows. A 10% w/w solution of PVA with greater than 99.4% saponification was prepared in distilled boiling water to allow complete dissolution. The solution was placed in an oven at 100掳C for 2 h in order for water to evaporate. The dried films were annealed in a vacuum oven at 120掳C for 1 h at 30 mmHg pressure to induce maximum crystallization of PVA. Samples were allowed to swell in distilled water for at least 48 h. After reaching equilibrium swelling, different amounts of purified AA or NV? ranging from 5 to 30% based on PVA was added to the aqueous solution, poured in a glass vial, purged with nitrogen, sealed with plastic top, and each vial was exposed to gamma radiation. After irradiation, the samples were washed twice with distilled water to remove uncrosslinked polymer and dried in vaccu at 40掳C for 12 h. The percent grafting was determined by measuring the weight of dry sample before and after irradiation. The percent swelling was determined by measuring the weight of swollen and dry sample in phosphate buffer solution with pH 7. for biocompatibility, Cell culture was performed using the ASTM-F813 standard procedure. Samples were sterilized by UV radiation and subsequent washing with ethanol and placed in sterilized peth dishes containing the culture medium at 37掳C. Antibacterial agents Penicillin G and Streptomycin were added to the petri dish in order to deactivate any remaining bacteria. Fibroblast cells, obtained from fran Pasture Institute, with concentration of 1 .3x105 cell/mi were added to each pen-i dish and placed in a CO, incubator at 37掳C for 24 h. After cell culture, the samples were washed with PBS buffer. The remaining cells on the surface after washing were fixed with gluteraldhyde and stained with trepan blue for microscopic observation. Ungrafted PVA had about 40% by weight water absorption. When PVA was grafted with 10%, 20% and 30% AA, water absorption increased to 45%, 50% and 55%. On the other hand, when PVA was grafted with 10%, 20%, and 30% NVP, water absorption increased to 65%, 72% and 78%. As the PVA was grafted with 10%, 20% and 30% AA, cell toxicity increased significantly such that no cell growth was observed on the sample with 30% grafted AA. On the other hand, as the PVA was grafted with 10%, 20%, and 30% NVP, cell compatibility increased significantly compared with ungrafted PVA. Also, the NVP grafted PVA samples also had higher compression modulus. Therefore, the results indicate that the NV? grafted PVA is more suitable for use as artificial cartilage compared to ungrafted PVA.","grobid_abstract_attachment_id":53973268},"translated_abstract":null,"internal_url":"https://www.academia.edu/34032111/Effect_Of_Grafting_N_Vinyl_Pyrollidone_or_Acrylic_Acid_on_Cytotoxicity_Water_Absorption_and_Compression_Modulus_of_Crosslinked_Polyvinyl_Alcohol_as_Artificial_Cartilage","translated_internal_url":"","created_at":"2017-07-25T08:47:12.104-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":29854087,"work_id":34032111,"tagging_user_id":66499940,"tagged_user_id":32340991,"co_author_invite_id":null,"email":"j***i@engr.sc.edu","affiliation":"University of South Carolina","display_order":0,"name":"Esmaiel Jabbari","title":"Effect Of Grafting N-Vinyl Pyrollidone or Acrylic Acid on Cytotoxicity, Water Absorption, and Compression Modulus of Crosslinked Polyvinyl Alcohol as Artificial Cartilage"}],"downloadable_attachments":[{"id":53973268,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973268/thumbnails/1.jpg","file_name":"Effect_Of_Grafting_N-Vinyl_Pyrollidone_o20170725-25623-nyov1u.pdf","download_url":"https://www.academia.edu/attachments/53973268/download_file","bulk_download_file_name":"Effect_Of_Grafting_N_Vinyl_Pyrollidone_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973268/Effect_Of_Grafting_N-Vinyl_Pyrollidone_o20170725-25623-nyov1u-libre.pdf?1500997978=\u0026response-content-disposition=attachment%3B+filename%3DEffect_Of_Grafting_N_Vinyl_Pyrollidone_o.pdf\u0026Expires=1743370487\u0026Signature=GETe~3Bq8Pu9l3C0m~TsbyJDNqYT~wV4mWFwEZp0i192BRqoL9AR8EI1tus2ie06UghvxB6WTLPZVauoZ4yYbYQswVZYdNAlHsC6E9qh8q0lCdZwjuFrBtMU04NdpbbEmxjMU~23UoZEcIgzaOU99u-XXExrsqFNU8yxs1jpc9eA-h-tyzeFhGwZ2qsFC1uwzXMY3wuRj5LG6XzRcb0KWAH8oUYNyAtMHz-yatDq6EoL5SUQ09PVE5zFJ8mk4hpjTrSsUowNGtGudFwDABZM84qM3FSp0VN5XXcfm2sxKjQdVi8CDfcLDCxCsMa1t26I-wvPHn9nxcEpeS9SHcgfbw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effect_Of_Grafting_N_Vinyl_Pyrollidone_or_Acrylic_Acid_on_Cytotoxicity_Water_Absorption_and_Compression_Modulus_of_Crosslinked_Polyvinyl_Alcohol_as_Artificial_Cartilage","translated_slug":"","page_count":6,"language":"en","content_type":"Work","summary":"Articular cartilage is a thin layer covering the opposed bony faces, which aids in force absorption and acts as a low friction bearing for the two surfaces of the joint. Osteoarthritis results in a wearing away of this material which results in an increase in friction, stiffness, and pain. fully saturated natural cartilage contains 70-80 percent water. Hydrogels based on polyvinyl alcohol (PVA) have excellent biocompatibility and mechanical properties, however their maximum water absorption capacity is around 40%. The objective of this research was to investigate the effect of gamma radiation grafting of acrylic acid (AA) or N-vinyl pyrollidone (NVP) on water absorption, compression modulus, and biocompatibility of semicrystalline PVA hydrogel as an artificial carthage. PVA hydrogel was prepared as follows. A 10% w/w solution of PVA with greater than 99.4% saponification was prepared in distilled boiling water to allow complete dissolution. The solution was placed in an oven at 100掳C for 2 h in order for water to evaporate. The dried films were annealed in a vacuum oven at 120掳C for 1 h at 30 mmHg pressure to induce maximum crystallization of PVA. Samples were allowed to swell in distilled water for at least 48 h. After reaching equilibrium swelling, different amounts of purified AA or NV? ranging from 5 to 30% based on PVA was added to the aqueous solution, poured in a glass vial, purged with nitrogen, sealed with plastic top, and each vial was exposed to gamma radiation. After irradiation, the samples were washed twice with distilled water to remove uncrosslinked polymer and dried in vaccu at 40掳C for 12 h. The percent grafting was determined by measuring the weight of dry sample before and after irradiation. The percent swelling was determined by measuring the weight of swollen and dry sample in phosphate buffer solution with pH 7. for biocompatibility, Cell culture was performed using the ASTM-F813 standard procedure. Samples were sterilized by UV radiation and subsequent washing with ethanol and placed in sterilized peth dishes containing the culture medium at 37掳C. Antibacterial agents Penicillin G and Streptomycin were added to the petri dish in order to deactivate any remaining bacteria. Fibroblast cells, obtained from fran Pasture Institute, with concentration of 1 .3x105 cell/mi were added to each pen-i dish and placed in a CO, incubator at 37掳C for 24 h. After cell culture, the samples were washed with PBS buffer. The remaining cells on the surface after washing were fixed with gluteraldhyde and stained with trepan blue for microscopic observation. Ungrafted PVA had about 40% by weight water absorption. When PVA was grafted with 10%, 20% and 30% AA, water absorption increased to 45%, 50% and 55%. On the other hand, when PVA was grafted with 10%, 20%, and 30% NVP, water absorption increased to 65%, 72% and 78%. As the PVA was grafted with 10%, 20% and 30% AA, cell toxicity increased significantly such that no cell growth was observed on the sample with 30% grafted AA. On the other hand, as the PVA was grafted with 10%, 20%, and 30% NVP, cell compatibility increased significantly compared with ungrafted PVA. Also, the NVP grafted PVA samples also had higher compression modulus. Therefore, the results indicate that the NV? grafted PVA is more suitable for use as artificial cartilage compared to ungrafted PVA.","owner":{"id":66499940,"first_name":"Saeed","middle_initials":null,"last_name":"Karbasi","page_name":"SaeedKarbasi","domain_name":"mui","created_at":"2017-07-17T06:31:55.223-07:00","display_name":"Saeed Karbasi","url":"https://mui.academia.edu/SaeedKarbasi"},"attachments":[{"id":53973268,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973268/thumbnails/1.jpg","file_name":"Effect_Of_Grafting_N-Vinyl_Pyrollidone_o20170725-25623-nyov1u.pdf","download_url":"https://www.academia.edu/attachments/53973268/download_file","bulk_download_file_name":"Effect_Of_Grafting_N_Vinyl_Pyrollidone_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973268/Effect_Of_Grafting_N-Vinyl_Pyrollidone_o20170725-25623-nyov1u-libre.pdf?1500997978=\u0026response-content-disposition=attachment%3B+filename%3DEffect_Of_Grafting_N_Vinyl_Pyrollidone_o.pdf\u0026Expires=1743370487\u0026Signature=GETe~3Bq8Pu9l3C0m~TsbyJDNqYT~wV4mWFwEZp0i192BRqoL9AR8EI1tus2ie06UghvxB6WTLPZVauoZ4yYbYQswVZYdNAlHsC6E9qh8q0lCdZwjuFrBtMU04NdpbbEmxjMU~23UoZEcIgzaOU99u-XXExrsqFNU8yxs1jpc9eA-h-tyzeFhGwZ2qsFC1uwzXMY3wuRj5LG6XzRcb0KWAH8oUYNyAtMHz-yatDq6EoL5SUQ09PVE5zFJ8mk4hpjTrSsUowNGtGudFwDABZM84qM3FSp0VN5XXcfm2sxKjQdVi8CDfcLDCxCsMa1t26I-wvPHn9nxcEpeS9SHcgfbw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-34032111-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="34032110"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/34032110/A_Comparative_Study_of_Articular_Chondrocytes_Metabolism_on_a_Biodegradable_Polyesterurethane_Scaffold_and_Alginate_in_Different_Oxygen_Tension_and_pH"><img alt="Research paper thumbnail of A Comparative Study of Articular Chondrocytes Metabolism on a Biodegradable Polyesterurethane Scaffold and Alginate in Different Oxygen Tension and pH" class="work-thumbnail" src="https://attachments.academia-assets.com/53973270/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/34032110/A_Comparative_Study_of_Articular_Chondrocytes_Metabolism_on_a_Biodegradable_Polyesterurethane_Scaffold_and_Alginate_in_Different_Oxygen_Tension_and_pH">A Comparative Study of Articular Chondrocytes Metabolism on a Biodegradable Polyesterurethane Scaffold and Alginate in Different Oxygen Tension and pH</a></div><div class="wp-workCard_item"><span>IFMBE proceedings</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">There are some different methods in the literatures that used for healing and repairing of cartil...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">There are some different methods in the literatures that used for healing and repairing of cartilage. One of the methods for increasing of regeneration and metabolism in cartilage, is stimulating physicochemical parameters on cellpolymer systems, as cartilage based cells. In this research, two physicochemical parameters, oxygen tension and pH, was changed to measure the lactate production after 1, 2 and 3 days culture and GAG(glycosaminoglycan) production after 3, 7 and 14 days culture of chondrocytes on DegraPol庐, as a biodegradable polyurethane scaffold (BPUS), and alginate scaffolds. The results finally were compared on both scaffolds. The results showed that physicochemical parameters like oxygen tension and pH could change cell metabolism. In fact, the physicochemical parameters could affect lactate production and GAG content of chondrocyte cells and it does not depend on the type of scaffold. The best condition of the articular chondrocytes metabolism was for 5% O2 and pH=7.4(p<0.001). The comparison between BPUS and alginate scaffold is showing that the results are better for alginate beads (p<0.001). In fact, hydrophilicity of alginate causes better cell distribution and nutrition than BPUS; because the cells are able to transfer the ions and the products through the medium easily.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="745a8bf0c6aad45e2af5a36a157091a1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53973270,"asset_id":34032110,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53973270/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="34032110"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="34032110"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34032110; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34032110]").text(description); $(".js-view-count[data-work-id=34032110]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34032110; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='34032110']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "745a8bf0c6aad45e2af5a36a157091a1" } } $('.js-work-strip[data-work-id=34032110]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":34032110,"title":"A Comparative Study of Articular Chondrocytes Metabolism on a Biodegradable Polyesterurethane Scaffold and Alginate in Different Oxygen Tension and pH","translated_title":"","metadata":{"grobid_abstract":"There are some different methods in the literatures that used for healing and repairing of cartilage. One of the methods for increasing of regeneration and metabolism in cartilage, is stimulating physicochemical parameters on cellpolymer systems, as cartilage based cells. In this research, two physicochemical parameters, oxygen tension and pH, was changed to measure the lactate production after 1, 2 and 3 days culture and GAG(glycosaminoglycan) production after 3, 7 and 14 days culture of chondrocytes on DegraPol庐, as a biodegradable polyurethane scaffold (BPUS), and alginate scaffolds. The results finally were compared on both scaffolds. The results showed that physicochemical parameters like oxygen tension and pH could change cell metabolism. In fact, the physicochemical parameters could affect lactate production and GAG content of chondrocyte cells and it does not depend on the type of scaffold. The best condition of the articular chondrocytes metabolism was for 5% O2 and pH=7.4(p\u003c0.001). The comparison between BPUS and alginate scaffold is showing that the results are better for alginate beads (p\u003c0.001). In fact, hydrophilicity of alginate causes better cell distribution and nutrition than BPUS; because the cells are able to transfer the ions and the products through the medium easily.","publication_name":"IFMBE proceedings","grobid_abstract_attachment_id":53973270},"translated_abstract":null,"internal_url":"https://www.academia.edu/34032110/A_Comparative_Study_of_Articular_Chondrocytes_Metabolism_on_a_Biodegradable_Polyesterurethane_Scaffold_and_Alginate_in_Different_Oxygen_Tension_and_pH","translated_internal_url":"","created_at":"2017-07-25T08:47:11.864-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":66499940,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":53973270,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/53973270/thumbnails/1.jpg","file_name":"A_Comparative_Study_of_Articular_Chondro20170725-25620-1e1vlg7.pdf","download_url":"https://www.academia.edu/attachments/53973270/download_file","bulk_download_file_name":"A_Comparative_Study_of_Articular_Chondro.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/53973270/A_Comparative_Study_of_Articular_Chondro20170725-25620-1e1vlg7-libre.pdf?1500997975=\u0026response-content-disposition=attachment%3B+filename%3DA_Comparative_Study_of_Articular_Chondro.pdf\u0026Expires=1743370487\u0026Signature=M1zLWnLNkvIhjFqLG3lQkQCftVx09IOSZ2sQSmpuHQKVcRjXqNvyL2SlibR0KudjkpxWQOjCuB0lQ2VJIQroF96kGOVdtQLyKpDr5RBLmrG5u3D7jgqBe1wHLrz~U0eoLF~Tutpw9RlnCb4vCLmWkuUcbb1ujp7nGoAWBC2FTf58VFN5e2waQT4vuuRJG5qmU95QPWLcDb0t9i7pTv-4U4o5ATTm5nh6Q2yFysPAapcr01SIXTssROe8Si39x71H~lE9zn2CwrpmLqVGUAmZCw~OsOZ1U86QRc4YfJgmgrIicjTVC2yzDugmWUvhfF68OhzIDXJ9KV3HSSlbJQ3wjQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_Comparative_Study_of_Articular_Chondrocytes_Metabolism_on_a_Biodegradable_Polyesterurethane_Scaffold_and_Alginate_in_Different_Oxygen_Tension_and_pH","translated_slug":"","page_count":4,"language":"en","content_type":"Work","summary":"There are some different methods in the literatures that used for healing and repairing of cartilage. One of the methods for increasing of regeneration and metabolism in cartilage, is stimulating physicochemical parameters on cellpolymer systems, as cartilage based cells. In this research, two physicochemical parameters, oxygen tension and pH, was changed to measure the lactate production after 1, 2 and 3 days culture and GAG(glycosaminoglycan) production after 3, 7 and 14 days culture of chondrocytes on DegraPol庐, as a biodegradable polyurethane scaffold (BPUS), and alginate scaffolds. The results finally were compared on both scaffolds. The results showed that physicochemical parameters like oxygen tension and pH could change cell metabolism. In fact, the physicochemical parameters could affect lactate production and GAG content of chondrocyte cells and it does not depend on the type of scaffold. The best condition of the articular chondrocytes metabolism was for 5% O2 and pH=7.4(p\u003c0.001). The comparison between BPUS and alginate scaffold is showing that the results are better for alginate beads (p\u003c0.001). 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