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href="https://de.wikipedia.org/wiki/Wybutosin" title="Wybutosin – allemand" lang="de" hreflang="de" data-title="Wybutosin" data-language-autonym="Deutsch" data-language-local-name="allemand" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Wybutosine" title="Wybutosine – anglais" lang="en" hreflang="en" data-title="Wybutosine" data-language-autonym="English" data-language-local-name="anglais" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%9C%84%EB%B6%80%ED%86%A0%EC%8B%A0" title="위부토신 – coréen" lang="ko" hreflang="ko" data-title="위부토신" data-language-autonym="한국어" data-language-local-name="coréen" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Wibutosina" title="Wibutosina – malais" lang="ms" hreflang="ms" data-title="Wibutosina" data-language-autonym="Bahasa Melayu" data-language-local-name="malais" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Wybutoz%C3%ADn" title="Wybutozín – slovaque" lang="sk" hreflang="sk" data-title="Wybutozín" data-language-autonym="Slovenčina" data-language-local-name="slovaque" class="interlanguage-link-target"><span>Slovenčina</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q1310878#sitelinks-wikipedia" title="Modifier les liens interlangues" class="wbc-editpage">Modifier les liens</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Espaces de noms"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Wybutosine" title="Voir le contenu de la page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Discussion:Wybutosine" rel="discussion" title="Discussion au sujet de cette page de contenu [t]" accesskey="t"><span>Discussion</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Modifier la variante de langue" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">français</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Affichages"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Wybutosine"><span>Lire</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Wybutosine&veaction=edit" title="Modifier cette page [v]" 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cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Outils</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Outils</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">déplacer vers la barre latérale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">masquer</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Plus d’options" > <div class="vector-menu-heading"> Actions </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Wybutosine"><span>Lire</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Wybutosine&veaction=edit" title="Modifier cette page [v]" accesskey="v"><span>Modifier</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Wybutosine&action=edit" title="Modifier le wikicode de cette page [e]" accesskey="e"><span>Modifier le code</span></a></li><li id="ca-more-history" 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href="/w/index.php?title=Sp%C3%A9cial:QrCode&url=https%3A%2F%2Ffr.wikipedia.org%2Fwiki%2FWybutosine"><span>Télécharger le code QR</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Imprimer / exporter </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:Livre&bookcmd=book_creator&referer=Wybutosine"><span>Créer un livre</span></a></li><li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:DownloadAsPdf&page=Wybutosine&action=show-download-screen"><span>Télécharger comme PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Wybutosine&printable=yes" title="Version imprimable de cette page [p]" accesskey="p"><span>Version imprimable</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> Dans d’autres projets </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q1310878" title="Lien vers l’élément dans le dépôt de données connecté [g]" accesskey="g"><span>Élément Wikidata</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Outils de la page"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Apparence"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Apparence</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">déplacer vers la barre latérale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">masquer</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Un article de Wikipédia, l'encyclopédie libre.</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="fr" dir="ltr"><p class="mw-empty-elt"> </p> <table class="infobox_v2 infobox infobox--frwiki noarchive"> <tbody><tr> <td colspan="2" class="entete defaut" style="background-color:#FFDEAD;color:black;">Wybutosine </td></tr> <tr><td colspan="2" style="text-align:center; line-height: 1.5em;"><span typeof="mw:File/Frameless"><a href="/w/index.php?title=Fichier:Wybutosine.svg&lang=fr" class="mw-file-description"><img alt="Image illustrative de l’article Wybutosine" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/cf/Wybutosine.svg/langfr-250px-Wybutosine.svg.png" decoding="async" width="250" height="217" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/cf/Wybutosine.svg/langfr-375px-Wybutosine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/cf/Wybutosine.svg/langfr-500px-Wybutosine.svg.png 2x" data-file-width="620" data-file-height="537" /></a></span> </td></tr> <tr> <td colspan="2" style="text-align:center;">Structure de la wybutosine</td> </tr><tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#FFDEAD; color:#000000">Identification</th></tr> <tr> <th scope="row"><a href="/wiki/Nomenclature_de_l%27UICPA" title="Nomenclature de l'UICPA">Nom UICPA</a> </th> <td><small>7-{(3<i>S</i>)-4-méthoxy-3-[(méthoxycarbonyl)amino]-4-oxobutyl}-4,6-diméthyl-3-(β-<small>D</small>-ribofuranosyl)-3,4-dihydro-9<i>H</i>-imidazo[1,2-<i>a</i>]purin-9-one</small> </td> </tr> <tr> <th scope="row"><a href="/wiki/Synonymie" title="Synonymie">Synonymes</a> </th> <td> <p>yW </p> </td> </tr> <tr> <th scope="row"><a href="/wiki/PubChem" title="PubChem">PubChem</a> </th> <td><span class="plainlinks"><span class="noarchive"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/90658156">90658156</a></span></span> </td> </tr> <tr> <th scope="row">ChEBI </th> <td><span class="plainlinks"><span class="noarchive"><a rel="nofollow" class="external text" href="http://www.ebi.ac.uk/chebi/searchId.do?chebiId=46574">46574</a></span></span> </td> </tr> <tr> <th scope="row"><a href="/wiki/Simplified_Molecular_Input_Line_Entry_System" title="Simplified Molecular Input Line Entry System">SMILES</a> </th> <td><div class="NavFrame" title="[afficher]/[masquer]" style="border: none; padding: 0;"><div class="NavContent" style="display: none; text-align: left;">COC(=O)N[C@@H](CCc1c(C)nc2n(C)c3n(cnc3c(=O)n12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)C(=O)OC <br /><span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://pubchem.ncbi.nlm.nih.gov/search/?smarts=COC%28%3DO%29N%5BC%40%40H%5D%28CCc1c%28C%29nc2n%28C%29c3n%28cnc3c%28%3DO%29n12%29%5BC%40%40H%5D1O%5BC%40H%5D%28CO%29%5BC%40%40H%5D%28O%29%5BC%40H%5D1O%29C%28%3DO%29OC">PubChem</a></span>, <span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://chemapps.stolaf.edu/jmol/jmol.php?title=Wybutosine&model=COC%28%3DO%29N%5BC%40%40H%5D%28CCc1c%28C%29nc2n%28C%29c3n%28cnc3c%28%3DO%29n12%29%5BC%40%40H%5D1O%5BC%40H%5D%28CO%29%5BC%40%40H%5D%28O%29%5BC%40H%5D1O%29C%28%3DO%29OC">vue 3D</a></span></div></div> </td> </tr> <tr> <th scope="row"><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a> </th> <td><div class="NavFrame" title="[afficher]/[masquer]" style="border: none; padding: 0;"><div class="NavContent" style="display: none; text-align: left;"><b>Std. InChI :</b> <span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://chemapps.stolaf.edu/jmol/jmol.php?title=Wybutosine&model=InChI%3D1S%2FC21H28N6O9%2Fc1-9-11%286-5-10%2819%2832%2934-3%2924-21%2833%2935-4%2927-17%2831%2913-16%2825%282%2920%2827%2923-9%2926%288-22-13%2918-15%2830%2914%2829%2912%287-28%2936-18%2Fh8%2C10%2C12%2C14-15%2C18%2C28-30H%2C5-7H2%2C1-4H3%2C%28H%2C24%2C33%29%2Ft10-%2C12%2B%2C14%2B%2C15%2B%2C18%2B%2Fm0%2Fs1">vue 3D</a></span> <br />InChI=1S/C21H28N6O9/c1-9-11(6-5-10(19(32)34-3)24-21(33)35-4)27-17(31)13-16(25(2)20(27)23-9)26(8-22-13)18-15(30)14(29)12(7-28)36-18/h8,10,12,14-15,18,28-30H,5-7H2,1-4H3,(H,24,33)/t10-,12+,14+,15+,18+/m0/s1 <br /><b>Std. InChIKey :</b> <br />QAOHCFGKCWTBGC-QHOAOGIMSA-N</div></div> </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#FFDEAD; color:#000000">Propriétés chimiques</th></tr> <tr> <th scope="row"><a href="/wiki/Formule_chimique" title="Formule chimique">Formule</a> </th> <td><a href="/wiki/Carbone" title="Carbone">C</a><sub>21</sub><a href="/wiki/Hydrog%C3%A8ne" title="Hydrogène">H</a><sub>28</sub><a href="/wiki/Azote" title="Azote">N</a><sub>6</sub><a href="/wiki/Oxyg%C3%A8ne" title="Oxygène">O</a><sub>9</sub>  <span class="page_h"><a href="/wiki/C21H28N6O9" class="mw-redirect" title="C21H28N6O9"><small>[Isomères]</small></a></span><br /> </td> </tr> <tr> <th scope="row"><a href="/wiki/Masse_molaire" title="Masse molaire">Masse molaire</a><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </th> <td>508,481 8 ± 0,022 7 <a href="/wiki/Gramme" title="Gramme">g</a>/<a href="/wiki/Mole_(unit%C3%A9)" title="Mole (unité)">mol</a> <br /><small>C 49,6 %,  H 5,55 %,  N 16,53 %,  O 28,32 %,  </small> </td> </tr> <tr> <td colspan="2"><hr style="height:2px; background-color:#FFDEAD;" /></td></tr> <tr> <td colspan="2" style="text-align:center;">Unités du <a href="/wiki/Syst%C3%A8me_international_d%27unit%C3%A9s" title="Système international d'unités">SI</a> et <a href="/wiki/Conditions_normales_de_temp%C3%A9rature_et_de_pression" title="Conditions normales de température et de pression"><abbr title="conditions normales de température et de pression">CNTP</abbr></a>, sauf indication contraire.</td> </tr><tr> <td class="navigation-only" colspan="2" style="border-top: 2px #FFDEAD solid; font-size: 80%; background:inherit; color: inherit; text-align: right;"><span class="plainlinks" style="float:left;"><a class="external text" href="https://fr.wikipedia.org/w/index.php?title=Wybutosine&action=edit&section=0"><span class="infodoc">modifier</span></a></span> <span typeof="mw:File"><a href="/wiki/Mod%C3%A8le:Infobox_Chimie" title="Consultez la documentation du modèle"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/12px-Info_Simple.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/18px-Info_Simple.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/24px-Info_Simple.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span></td> </tr> </tbody></table> <p>La <b>wybutosine</b> est un <a href="/wiki/Nucl%C3%A9oside" title="Nucléoside">nucléoside</a> fortement modifié contenant de la <a href="/wiki/Wyosine" title="Wyosine">wyosine</a> et dérivé de la <a href="/wiki/Guanosine" title="Guanosine">guanosine</a> qu'on trouve dans certains <a href="/wiki/Acide_ribonucl%C3%A9ique_de_transfert" title="Acide ribonucléique de transfert">ARN de transfert</a> où elle stabilise les interactions entre les <a href="/wiki/Codon" title="Codon">codons</a> et <a href="/wiki/Anticodon" title="Anticodon">anticodons</a> lors de la <a href="/wiki/Biosynth%C3%A8se_des_prot%C3%A9ines" title="Biosynthèse des protéines">biosynthèse des protéines</a> par les <a href="/wiki/Ribosome" title="Ribosome">ribosomes</a><sup id="cite_ref-10.1038/sj.emboj.7601105_2-0" class="reference"><a href="#cite_note-10.1038/sj.emboj.7601105-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>. Chez les <a href="/wiki/Eucaryote" class="mw-redirect" title="Eucaryote">eucaryotes</a>, ce nucléoside n'est présent qu'en position 37 de l'ARNt de <a href="/wiki/Ph%C3%A9nylalanine" title="Phénylalanine">phénylalanine</a>, c'est-à-dire au contact de l'extrémité 3’ de l'anticodon, dont il stabilise l'<a href="/wiki/Paire_de_bases" title="Paire de bases">appariement</a> des <a href="/wiki/Base_nucl%C3%A9ique" class="mw-redirect" title="Base nucléique">bases nucléiques</a> avec le codon sur l'<a href="/wiki/Acide_ribonucl%C3%A9ique_messager" title="Acide ribonucléique messager">ARN messager</a><sup id="cite_ref-10.1016/j.jmb.2007.07.024_3-0" class="reference"><a href="#cite_note-10.1016/j.jmb.2007.07.024-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>. Il est conservé chez les eucaryotes et les <a href="/wiki/Archaea" title="Archaea">archées</a>, mais est absent chez les <a href="/wiki/Bact%C3%A9rie" title="Bactérie">bactéries</a>. </p><p>La grande taille de la base nucléique de ce nucléoside a pour effet d'accroître les interactions d'empilement avec les bases adjacentes, ce qui réduit la flexibilité de l'ARN au niveau de l'anticodon et limite les <a href="/wiki/D%C3%A9calage_du_cadre_de_lecture" title="Décalage du cadre de lecture">décalages de cadre de lecture</a><sup id="cite_ref-10.1016/j.jmb.2003.09.058_4-0" class="reference"><a href="#cite_note-10.1016/j.jmb.2003.09.058-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>. D'une manière générale, les bases en position 34 et 37 des ARN de transfert sont très souvent modifiées, ce qui souligne leur rôle déterminant dans l'exactitude de la <a href="/wiki/Traduction_g%C3%A9n%C3%A9tique" title="Traduction génétique">traduction génétique</a>. </p><p>Il est possible que la présence de wybutosine en position 37 des <a href="/wiki/Acide_ribonucl%C3%A9ique_de_transfert" title="Acide ribonucléique de transfert">ARNt</a><sup><a href="/wiki/Ph%C3%A9nylalanine" title="Phénylalanine">Phe</a></sup> ait un rapport avec la <a href="/wiki/S%C3%A9quence_(acide_nucl%C3%A9ique)" title="Séquence (acide nucléique)">séquence</a> du <a href="/wiki/Codon" title="Codon">codon</a> de la <a href="/wiki/Ph%C3%A9nylalanine" title="Phénylalanine">phénylalanine</a>, qui est UUU ou UUC : la présence de tels codons est susceptible de générer des « <a href="/wiki/S%C3%A9quence_glissante" title="Séquence glissante">séquences glissantes</a> » sur l'<a href="/wiki/Acide_ribonucl%C3%A9ique_messager" title="Acide ribonucléique messager">ARN messager</a>, séquences elles-mêmes susceptibles de décaler le <a href="/wiki/Cadre_de_lecture" title="Cadre de lecture">cadre de lecture</a> des <a href="/wiki/Ribosome" title="Ribosome">ribosomes</a>, d'où l'importance de bases modifiées sur l'ARNt capables de contrôler l'exactitude de la traduction en évitant précisément de tels décalages du cadre de lecture<sup id="cite_ref-10.1016/j.jmb.2010.05.003_5-0" class="reference"><a href="#cite_note-10.1016/j.jmb.2010.05.003-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>. </p> <figure class="mw-default-size mw-halign-center" typeof="mw:File/Thumb"><a href="/wiki/Fichier:TRNA-Phe_yeast_en.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/TRNA-Phe_yeast_en.svg/330px-TRNA-Phe_yeast_en.svg.png" decoding="async" width="330" height="410" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/TRNA-Phe_yeast_en.svg/500px-TRNA-Phe_yeast_en.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/59/TRNA-Phe_yeast_en.svg/660px-TRNA-Phe_yeast_en.svg.png 2x" data-file-width="620" data-file-height="771" /></a><figcaption><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <a href="/wiki/Acide_ribonucl%C3%A9ique_de_transfert" title="Acide ribonucléique de transfert">ARN de transfert</a> de <a href="/wiki/Ph%C3%A9nylalanine" title="Phénylalanine">phénylalanine</a> de <a href="/wiki/Levure" title="Levure">levure</a>, montrant les <a href="/wiki/Base_nucl%C3%A9ique" class="mw-redirect" title="Base nucléique">bases nucléiques</a> modifiées en bleu : <br />   - <b><a href="/wiki/M%C3%A8tre_carr%C3%A9" title="Mètre carré">m<sup>2</sup></a>G</b> : 2-méthylguanosine <br />   - <b>D</b> : <a href="/w/index.php?title=5,6-dihydro-uridine&action=edit&redlink=1" class="new" title="5,6-dihydro-uridine (page inexistante)">5,6-dihydro-uridine</a> <br />   - <b><a href="/wiki/M%C3%A8tre_carr%C3%A9" title="Mètre carré">m<sup>2</sup></a><sub>2</sub>G</b> : N2-diméthylguanosine <br />   - <b>C<sub>m</sub></b> : O2'-méthylcytidine <br />   - <b>G<sub>m</sub></b> : O2'-méthylguanosine <br />   - <b>T</b> : <a href="/wiki/Ribothymidine" title="Ribothymidine">ribothymidine</a> (5-méthyluridine) <br />   - <span style="color:#AD0000"><b>Y</b> : <b>wybutosine</b></span> <br />   - <b>Ψ</b> : <a href="/wiki/Pseudouridine" title="Pseudouridine">pseudo-uridine</a> <br />   - <b>m<sup>5</sup>C</b> : <a href="/wiki/5-M%C3%A9thylcytidine" title="5-Méthylcytidine">5-méthylcytidine</a> <br />   - <b>m<sup>7</sup>G</b> : <a href="/wiki/7-M%C3%A9thylguanosine" title="7-Méthylguanosine">7-méthylguanosine</a> <br />   - <b>m<sup>1</sup>A</b> : 1-méthyladénosine.</figcaption></figure> <div class="mw-heading mw-heading2"><h2 id="Notes_et_références"><span id="Notes_et_r.C3.A9f.C3.A9rences"></span>Notes et références</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Wybutosine&veaction=edit&section=1" title="Modifier la section : Notes et références" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Wybutosine&action=edit&section=1" title="Modifier le code source de la section : Notes et références"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="references-small decimal" style=""><div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a> </span><span class="reference-text">Masse molaire calculée d’après <span class="ouvrage">« <a rel="nofollow" class="external text" href="http://www.chem.qmul.ac.uk/iupac/AtWt/"><cite style="font-style:normal;"><span class="lang-en" lang="en">Atomic weights of the elements 2007</span></cite></a> », sur <span class="italique">www.chem.qmul.ac.uk</span></span>.</span> </li> <li id="cite_note-10.1038/sj.emboj.7601105-2"><span class="mw-cite-backlink"><a href="#cite_ref-10.1038/sj.emboj.7601105_2-0">↑</a> </span><span class="reference-text"> <span class="ouvrage" id="Akiko_Noma,_Yohei_Kirino,_Yoshiho_Ikeuchi_et_Tsutomu_Suzuki2006"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <span class="nom_auteur">Akiko Noma, Yohei Kirino, Yoshiho Ikeuchi et Tsutomu Suzuki</span>, « <cite style="font-style:normal" lang="en">Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA</cite> », <i><span class="lang-en" lang="en">The EMBO Journal</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 25, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 10,‎ <time class="nowrap" datetime="2006-05-17" data-sort-value="2006-05-17">17 mai 2006</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">2142-2154</span> <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/16642040">16642040</a></span>, <a href="/wiki/PubMed_Central" title="PubMed Central">PMCID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/1462984">1462984</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1038/sj.emboj.7601105">10.1038/sj.emboj.7601105</a></span>, <a rel="nofollow" class="external text" href="http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC1462984&blobtype=pdf">lire en ligne</a>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Biosynthesis+of+wybutosine%2C+a+hyper-modified+nucleoside+in+eukaryotic+phenylalanine+tRNA&rft.jtitle=The+EMBO+Journal&rft.issue=10&rft.aulast=Akiko+Noma%2C+Yohei+Kirino%2C+Yoshiho+Ikeuchi+et+Tsutomu+Suzuki&rft.date=2006-05-17&rft.volume=25&rft.pages=2142-2154&rft_id=info%3Adoi%2F10.1038%2Fsj.emboj.7601105&rft_id=info%3Apmid%2F16642040&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AWybutosine"></span></span></span> </li> <li id="cite_note-10.1016/j.jmb.2007.07.024-3"><span class="mw-cite-backlink"><a href="#cite_ref-10.1016/j.jmb.2007.07.024_3-0">↑</a> </span><span class="reference-text"> <span class="ouvrage" id="Yoko_Suzuki,_Akiko_Noma,_Tsutomu_Suzuki,_Miki_Senda,_Toshiya_Senda,_Ryuichiro_Ishitani_et_Osamu_Nureki2007"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <span class="nom_auteur">Yoko Suzuki, Akiko Noma, Tsutomu Suzuki, Miki Senda, Toshiya Senda, Ryuichiro Ishitani et Osamu Nureki</span>, « <cite style="font-style:normal" lang="en">Crystal Structure of the Radical SAM Enzyme Catalyzing Tricyclic Modified Base Formation in tRNA</cite> », <i><span class="lang-en" lang="en">Journal of Molecular Biology</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 372, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 5,‎ <time class="nowrap" datetime="2007-10-05" data-sort-value="2007-10-05">5 octobre 2007</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">1204-1214</span> <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/17727881">17727881</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016/j.jmb.2007.07.024">10.1016/j.jmb.2007.07.024</a></span>, <a rel="nofollow" class="external text" href="http://www.sciencedirect.com/science/article/pii/S0022283607009515">lire en ligne</a>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Crystal+Structure+of+the+Radical+SAM+Enzyme+Catalyzing+Tricyclic+Modified+Base+Formation+in+tRNA&rft.jtitle=Journal+of+Molecular+Biology&rft.issue=5&rft.aulast=Yoko+Suzuki%2C+Akiko+Noma%2C+Tsutomu+Suzuki%2C+Miki+Senda%2C+Toshiya+Senda%2C+Ryuichiro+Ishitani+et+Osamu+Nureki&rft.date=2007-10-05&rft.volume=372&rft.pages=1204-1214&rft_id=info%3Adoi%2F10.1016%2Fj.jmb.2007.07.024&rft_id=info%3Apmid%2F17727881&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AWybutosine"></span></span></span> </li> <li id="cite_note-10.1016/j.jmb.2003.09.058-4"><span class="mw-cite-backlink"><a href="#cite_ref-10.1016/j.jmb.2003.09.058_4-0">↑</a> </span><span class="reference-text"> <span class="ouvrage" id="John_W._Stuart,_Karl_M._Koshlap,_Richard_Guenther_et_Paul_F._Agris2003"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <span class="nom_auteur">John W. Stuart, Karl M. Koshlap, Richard Guenther et Paul F. Agris</span>, « <cite style="font-style:normal" lang="en">Naturally-occurring Modification Restricts the Anticodon Domain Conformational Space of tRNA<sup>Phe</sup></cite> », <i><span class="lang-en" lang="en">Journal of Molecular Biology</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 334, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 5,‎ <time class="nowrap" datetime="2003-12-12" data-sort-value="2003-12-12">12 décembre 2003</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">901-918</span> <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/14643656">14643656</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016/j.jmb.2003.09.058">10.1016/j.jmb.2003.09.058</a></span>, <a rel="nofollow" class="external text" href="http://www.sciencedirect.com/science/article/pii/S0022283603012221">lire en ligne</a>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Naturally-occurring+Modification+Restricts+the+Anticodon+Domain+Conformational+Space+of+tRNAPhe&rft.jtitle=Journal+of+Molecular+Biology&rft.issue=5&rft.aulast=John+W.+Stuart%2C+Karl+M.+Koshlap%2C+Richard+Guenther+et+Paul+F.+Agris&rft.date=2003-12-12&rft.volume=334&rft.pages=901-918&rft_id=info%3Adoi%2F10.1016%2Fj.jmb.2003.09.058&rft_id=info%3Apmid%2F14643656&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AWybutosine"></span></span></span> </li> <li id="cite_note-10.1016/j.jmb.2010.05.003-5"><span class="mw-cite-backlink"><a href="#cite_ref-10.1016/j.jmb.2010.05.003_5-0">↑</a> </span><span class="reference-text"> <span class="ouvrage" id="Thomas_Christian,_Georges_Lahoud,_Cuiping_Liu_et_Ya-Ming_Hou2010"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <span class="nom_auteur">Thomas Christian, Georges Lahoud, Cuiping Liu et Ya-Ming Hou</span>, « <cite style="font-style:normal" lang="en">Control of Catalytic Cycle by a Pair of Analogous tRNA Modification Enzymes</cite> », <i><span class="lang-en" lang="en">Journal of Molecular Biology</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 400, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 2,‎ <time class="nowrap" datetime="2010-07-09" data-sort-value="2010-07-09">9 juillet 2010</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">204-217</span> <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/20452364">20452364</a></span>, <a href="/wiki/PubMed_Central" title="PubMed Central">PMCID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/2892103">2892103</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1016/j.jmb.2010.05.003">10.1016/j.jmb.2010.05.003</a></span>, <a rel="nofollow" class="external text" href="http://www.sciencedirect.com/science/article/pii/S0022283610004699">lire en ligne</a>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Control+of+Catalytic+Cycle+by+a+Pair+of+Analogous+tRNA+Modification+Enzymes&rft.jtitle=Journal+of+Molecular+Biology&rft.issue=2&rft.aulast=Thomas+Christian%2C+Georges+Lahoud%2C+Cuiping+Liu+et+Ya-Ming+Hou&rft.date=2010-07-09&rft.volume=400&rft.pages=204-217&rft_id=info%3Adoi%2F10.1016%2Fj.jmb.2010.05.003&rft_id=info%3Apmid%2F20452364&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AWybutosine"></span></span></span> </li> </ol></div> </div> <ul id="bandeau-portail" class="bandeau-portail"><li><span class="bandeau-portail-element"><span class="bandeau-portail-icone"><span class="noviewer" typeof="mw:File"><a href="/wiki/Portail:Chimie" title="Portail de la chimie"><img alt="icône décorative" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/Nuvola_apps_edu_science.svg/24px-Nuvola_apps_edu_science.svg.png" decoding="async" width="24" height="24" class="mw-file-element" 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