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<div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Chemical compound</div> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): CX-516">CX-516</span></caption><tbody><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:CX-516-2D-skeletal.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/99/CX-516-2D-skeletal.svg/220px-CX-516-2D-skeletal.svg.png" decoding="async" width="220" height="112" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/99/CX-516-2D-skeletal.svg/330px-CX-516-2D-skeletal.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/99/CX-516-2D-skeletal.svg/440px-CX-516-2D-skeletal.svg.png 2x" data-file-width="395" data-file-height="201" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Ampalex</td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd"><a href="/wiki/Pharmacokinetics" title="Pharmacokinetics">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Biological_half-life" title="Biological half-life">Elimination <span class="nowrap">half-life</span></a></th><td class="infobox-data">45 minutes</td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">6-(Piperidin-1-ylcarbonyl)quinoxaline</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=154235-83-3">154235-83-3</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/148184">148184</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Guide_to_Pharmacology" title="Guide to Pharmacology">IUPHAR/BPS</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.guidetopharmacology.org"><a rel="nofollow" class="external text" href="https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4165">4165</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.130635.html">130635</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/Z5QU38B4V9">Z5QU38B4V9</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/C13675">C13675</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL136800">ChEMBL136800</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID70165574">DTXSID70165574</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q5014875#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ECHA_InfoCard" class="mw-redirect" title="ECHA InfoCard"><span title="echa.europa.eu">ECHA InfoCard</span></a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.237.047">100.237.047</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q5014875#P2566" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>14</sub><span title="Hydrogen">H</span><sub>15</sub><span title="Nitrogen">N</span><sub>3</sub><span title="Oxygen">O</span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7002241294000000000♠"></span>241.294</span> g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=O%3DC%28c2cc1nccnc1cc2%29N3CCCCC3">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">O=C(c2cc1nccnc1cc2)N3CCCCC3</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:ANDGGVOPIJEHOF-UHFFFAOYSA-N<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-below"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style><span class="nobold">  <span class="reflink plainlinks nourlexpansion"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Special:ComparePages&rev1=443492828&page2=CX-516">(verify)</a></span></span></td></tr></tbody></table> <p><b>CX-516</b> is an <a href="/wiki/Ampakine" title="Ampakine">ampakine</a> and <a href="/wiki/Nootropic" title="Nootropic">nootropic</a> that acts as an <a href="/wiki/AMPA_receptor" title="AMPA receptor">AMPA receptor</a> <a href="/wiki/Positive_allosteric_modulator" class="mw-redirect" title="Positive allosteric modulator">positive allosteric modulator</a> and had been undergoing <a href="/wiki/Drug_development" title="Drug development">development</a> by a collaboration between <a href="/wiki/Cortex_Pharmaceuticals" class="mw-redirect" title="Cortex Pharmaceuticals">Cortex</a>, <a href="/wiki/Shire_(pharmaceutical_company)" title="Shire (pharmaceutical company)">Shire</a>, and <a href="/wiki/Servier" class="mw-redirect" title="Servier">Servier</a>. It was studied as a potential treatment for <a href="/wiki/Alzheimer%27s_disease" title="Alzheimer's disease">Alzheimer's disease</a> under the brand name <b>Ampalex</b>, and was also being examined as a treatment for <a href="/wiki/ADHD" class="mw-redirect" title="ADHD">ADHD</a>. </p><p>CX-516 was the first ampakine compound developed by Cortex and while it showed good <i>in vitro</i> activity and positive results in animal tests, the human trials proved disappointing due mainly to low potency and short half-life. However, CX-516 is still widely used in animal research into the ampakine drugs and is the standard reference compound that newer, more potent drugs of this class such as <a href="/wiki/Farampator" title="Farampator">farampator</a> and <a href="/wiki/CX-717" class="mw-redirect" title="CX-717">CX-717</a> are compared to. </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CX-516&action=edit&section=1" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/AMPA_receptor_positive_allosteric_modulator" title="AMPA receptor positive allosteric modulator">AMPA receptor positive allosteric modulator</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CX-516&action=edit&section=2" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFDanysz2002" class="citation journal cs1">Danysz W (July 2002). "CX-516 Cortex pharmaceuticals". <i>Current Opinion in Investigational Drugs</i>. <b>3</b> (7): 1081–8. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12186271">12186271</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Opinion+in+Investigational+Drugs&rft.atitle=CX-516+Cortex+pharmaceuticals&rft.volume=3&rft.issue=7&rft.pages=1081-8&rft.date=2002-07&rft_id=info%3Apmid%2F12186271&rft.aulast=Danysz&rft.aufirst=W&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACX-516" class="Z3988"></span></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist 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navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Ionotropic_glutamate_receptor_modulators" title="Template:Ionotropic glutamate receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Ionotropic_glutamate_receptor_modulators" title="Template talk:Ionotropic glutamate receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Ionotropic_glutamate_receptor_modulators" title="Special:EditPage/Template:Ionotropic glutamate receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Ionotropic_glutamate_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Ionotropic_glutamate_receptor" title="Ionotropic glutamate receptor">Ionotropic glutamate receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/%CE%91-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid_receptor" class="mw-redirect" title="Α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor"><abbr title="α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor">AMPAR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <i>Main site agonists:</i> <a href="/wiki/5-Fluorowillardiine" title="5-Fluorowillardiine">5-Fluorowillardiine</a></li> <li><a href="/wiki/Acromelic_acid_A" title="Acromelic acid A">Acromelic acid (acromelate)</a></li> <li><a href="/wiki/AMPA" title="AMPA">AMPA</a></li> <li><a href="/w/index.php?title=%CE%92-N-Oxalylamino-L-Alanine&action=edit&redlink=1" class="new" title="Β-N-Oxalylamino-L-Alanine (page does not exist)">BOAA</a></li> <li><a href="/wiki/Domoic_acid" title="Domoic acid">Domoic acid</a></li> <li><a href="/wiki/Glutamate" class="mw-redirect" title="Glutamate">Glutamate</a></li> <li><a href="/wiki/Ibotenic_acid" title="Ibotenic acid">Ibotenic acid</a></li> <li><a href="/wiki/Proline" title="Proline">Proline</a></li> <li><a href="/wiki/Quisqualic_acid" title="Quisqualic acid">Quisqualic acid</a></li> <li><a href="/wiki/Willardiine" title="Willardiine">Willardiine</a>; <i>Positive allosteric modulators:</i> <a href="/wiki/Aniracetam" title="Aniracetam">Aniracetam</a></li> <li><a href="/wiki/Cyclothiazide" title="Cyclothiazide">Cyclothiazide</a></li> <li><a class="mw-selflink selflink">CX-516</a></li> <li><a href="/wiki/CX-546" title="CX-546">CX-546</a></li> <li><a href="/wiki/CX614" title="CX614">CX-614</a></li> <li><a href="/wiki/Farampator" title="Farampator">Farampator (CX-691, ORG-24448)</a></li> <li><a href="/wiki/CX717" title="CX717">CX-717</a></li> <li><a href="/wiki/CX-1739" class="mw-redirect" title="CX-1739">CX-1739</a></li> <li><a href="/w/index.php?title=CX-1942&action=edit&redlink=1" class="new" title="CX-1942 (page does not exist)">CX-1942</a></li> <li><a href="/wiki/Diazoxide" title="Diazoxide">Diazoxide</a></li> <li><a href="/wiki/Hydrochlorothiazide" title="Hydrochlorothiazide">Hydrochlorothiazide (HCTZ)</a></li> <li><a href="/wiki/IDRA-21" title="IDRA-21">IDRA-21</a></li> <li><a href="/w/index.php?title=LY-392098&action=edit&redlink=1" class="new" title="LY-392098 (page does not exist)">LY-392098</a></li> <li><a href="/w/index.php?title=LY-395153&action=edit&redlink=1" class="new" title="LY-395153 (page does not exist)">LY-395153</a></li> <li><a href="/wiki/LY-404187" title="LY-404187">LY-404187</a></li> <li><a href="/w/index.php?title=LY-451646&action=edit&redlink=1" class="new" title="LY-451646 (page does not exist)">LY-451646</a></li> <li><a href="/wiki/LY-503430" title="LY-503430">LY-503430</a></li> <li><a href="/wiki/Mibampator" title="Mibampator">Mibampator (LY-451395)</a></li> <li><a href="/wiki/Nooglutyl" title="Nooglutyl">Nooglutyl</a></li> <li><a href="/wiki/ORG-26576" title="ORG-26576">ORG-26576</a></li> <li><a href="/wiki/Oxiracetam" title="Oxiracetam">Oxiracetam</a></li> <li><a href="/wiki/PEPA_(drug)" title="PEPA (drug)">PEPA</a></li> <li><a href="/wiki/Pesampator" title="Pesampator">Pesampator (BIIB-104, PF-04958242)</a></li> <li><a href="/wiki/Piracetam" title="Piracetam">Piracetam</a></li> <li><a href="/wiki/Pramiracetam" title="Pramiracetam">Pramiracetam</a></li> <li><a href="/wiki/S-18986" title="S-18986">S-18986</a></li> <li><a href="/wiki/Tulrampator" title="Tulrampator">Tulrampator (S-47445, CX-1632)</a></li></ul> <ul><li><b>Antagonists:</b> <a href="/w/index.php?title=ACEA-1011&action=edit&redlink=1" class="new" title="ACEA-1011 (page does not exist)">ACEA-1011</a></li> <li><a href="/w/index.php?title=ATPO&action=edit&redlink=1" class="new" title="ATPO (page does not exist)">ATPO</a></li> <li><a href="/wiki/Becampanel" title="Becampanel">Becampanel</a></li> <li><a href="/wiki/Caroverine" title="Caroverine">Caroverine</a></li> <li><a href="/wiki/CNQX" title="CNQX">CNQX</a></li> <li><a href="/wiki/Dasolampanel" title="Dasolampanel">Dasolampanel</a></li> <li><a href="/wiki/DNQX" title="DNQX">DNQX</a></li> <li><a href="/wiki/Fanapanel" title="Fanapanel">Fanapanel (MPQX)</a></li> <li><a href="/w/index.php?title=Gamma-D-Glutamylaminomethylsulfonic_acid&action=edit&redlink=1" class="new" title="Gamma-D-Glutamylaminomethylsulfonic acid (page does not exist)">GAMS</a></li> <li><a href="/wiki/Kaitocephalin" title="Kaitocephalin">Kaitocephalin</a></li> <li><a href="/wiki/Kynurenic_acid" title="Kynurenic acid">Kynurenic acid</a></li> <li><a href="/wiki/Kynurenine" title="Kynurenine">Kynurenine</a></li> <li><a href="/wiki/Licostinel" title="Licostinel">Licostinel (ACEA-1021)</a></li> <li><a href="/wiki/NBQX" title="NBQX">NBQX</a></li> <li><a href="/w/index.php?title=PNQX&action=edit&redlink=1" class="new" title="PNQX (page does not exist)">PNQX</a></li> <li><a href="/wiki/Selurampanel" title="Selurampanel">Selurampanel</a></li> <li><a href="/wiki/Tezampanel" title="Tezampanel">Tezampanel</a></li> <li><a href="/wiki/Theanine" title="Theanine">Theanine</a></li> <li><a href="/wiki/Topiramate" title="Topiramate">Topiramate</a></li> <li><a href="/w/index.php?title=YM90K&action=edit&redlink=1" class="new" title="YM90K (page does not exist)">YM90K</a></li> <li><a href="/wiki/Zonampanel" title="Zonampanel">Zonampanel</a>; <i>Negative allosteric modulators:</i> <a href="/wiki/Barbiturates" class="mw-redirect" title="Barbiturates">Barbiturates</a> (e.g., <a href="/wiki/Pentobarbital" title="Pentobarbital">pentobarbital</a>, <a href="/wiki/Sodium_thiopental" title="Sodium thiopental">sodium thiopental</a>)</li> <li><a href="/wiki/Cyclopropane" title="Cyclopropane">Cyclopropane</a></li> <li><a href="/wiki/Enflurane" title="Enflurane">Enflurane</a></li> <li><a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">Ethanol (alcohol)</a></li> <li><a href="/wiki/Evans_blue_(dye)" title="Evans blue (dye)">Evans blue</a></li> <li><a href="/wiki/GYKI_52466" title="GYKI 52466">GYKI-52466</a></li> <li><a href="/w/index.php?title=GYKI-53655&action=edit&redlink=1" class="new" title="GYKI-53655 (page does not exist)">GYKI-53655</a></li> <li><a href="/wiki/Halothane" title="Halothane">Halothane</a></li> <li><a href="/wiki/Irampanel" title="Irampanel">Irampanel</a></li> <li><a href="/wiki/Isoflurane" title="Isoflurane">Isoflurane</a></li> <li><a href="/wiki/Perampanel" title="Perampanel">Perampanel</a></li> <li><a href="/wiki/Pregnenolone_sulfate" title="Pregnenolone sulfate">Pregnenolone sulfate</a></li> <li><a href="/wiki/Sevoflurane" title="Sevoflurane">Sevoflurane</a></li> <li><a href="/wiki/Talampanel" title="Talampanel">Talampanel</a>; <i>Unknown/unsorted antagonists:</i> <a href="/wiki/Minocycline" title="Minocycline">Minocycline</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Kainate_receptor" title="Kainate receptor"><abbr title="Kainate receptor">KAR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Kainate receptor</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <i>Main site agonists:</i> <a href="/w/index.php?title=5-Bromowillardiine&action=edit&redlink=1" class="new" title="5-Bromowillardiine (page does not exist)">5-Bromowillardiine</a></li> <li><a href="/wiki/5-Iodowillardiine" title="5-Iodowillardiine">5-Iodowillardiine</a></li> <li><a href="/w/index.php?title=Acromelic_acid&action=edit&redlink=1" class="new" title="Acromelic acid (page does not exist)">Acromelic acid (acromelate)</a></li> <li><a href="/wiki/AMPA" title="AMPA">AMPA</a></li> <li><a href="/w/index.php?title=ATPA&action=edit&redlink=1" class="new" title="ATPA (page does not exist)">ATPA</a></li> <li><a href="/wiki/Domoic_acid" title="Domoic acid">Domoic acid</a></li> <li><a href="/wiki/Glutamate" class="mw-redirect" title="Glutamate">Glutamate</a></li> <li><a href="/wiki/Ibotenic_acid" title="Ibotenic acid">Ibotenic acid</a></li> <li><a href="/wiki/Kainic_acid" title="Kainic acid">Kainic acid</a></li> <li><a href="/w/index.php?title=LY-339434&action=edit&redlink=1" class="new" title="LY-339434 (page does not exist)">LY-339434</a></li> <li><a href="/wiki/Proline" title="Proline">Proline</a></li> <li><a href="/wiki/Quisqualic_acid" title="Quisqualic acid">Quisqualic acid</a></li> <li><a href="/wiki/SYM-2081" title="SYM-2081">SYM-2081</a>; <i>Positive allosteric modulators:</i> <a href="/wiki/Cyclothiazide" title="Cyclothiazide">Cyclothiazide</a></li> <li><a href="/wiki/Diazoxide" title="Diazoxide">Diazoxide</a></li> <li><a href="/wiki/Enflurane" title="Enflurane">Enflurane</a></li> <li><a href="/wiki/Halothane" title="Halothane">Halothane</a></li> <li><a href="/wiki/Isoflurane" title="Isoflurane">Isoflurane</a></li></ul> <ul><li><b>Antagonists:</b> <a href="/w/index.php?title=ACEA-1011&action=edit&redlink=1" class="new" title="ACEA-1011 (page does not exist)">ACEA-1011</a></li> <li><a href="/wiki/CNQX" title="CNQX">CNQX</a></li> <li><a href="/wiki/Dasolampanel" title="Dasolampanel">Dasolampanel</a></li> <li><a href="/wiki/DNQX" title="DNQX">DNQX</a></li> <li><a href="/w/index.php?title=Gamma-D-Glutamylaminomethylsulfonic_acid&action=edit&redlink=1" class="new" title="Gamma-D-Glutamylaminomethylsulfonic acid (page does not exist)">GAMS</a></li> <li><a href="/wiki/Kaitocephalin" title="Kaitocephalin">Kaitocephalin</a></li> <li><a href="/wiki/Kynurenic_acid" title="Kynurenic acid">Kynurenic acid</a></li> <li><a href="/wiki/Licostinel" title="Licostinel">Licostinel (ACEA-1021)</a></li> <li><a href="/w/index.php?title=LY-382884&action=edit&redlink=1" class="new" title="LY-382884 (page does not exist)">LY-382884</a></li> <li><a href="/wiki/NBQX" title="NBQX">NBQX</a></li> <li><a href="/wiki/NS102" title="NS102">NS102</a></li> <li><a href="/wiki/Selurampanel" title="Selurampanel">Selurampanel</a></li> <li><a href="/wiki/Tezampanel" title="Tezampanel">Tezampanel</a></li> <li><a href="/wiki/Theanine" title="Theanine">Theanine</a></li> <li><a href="/wiki/Topiramate" title="Topiramate">Topiramate</a></li> <li><a href="/wiki/UBP-302" title="UBP-302">UBP-302</a>; <i>Negative allosteric modulators:</i> <a href="/wiki/Barbiturates" class="mw-redirect" title="Barbiturates">Barbiturates</a> (e.g., <a href="/wiki/Pentobarbital" title="Pentobarbital">pentobarbital</a>, <a href="/wiki/Sodium_thiopental" title="Sodium thiopental">sodium thiopental</a>)</li> <li><a href="/wiki/Enflurane" title="Enflurane">Enflurane</a></li> <li><a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">Ethanol (alcohol)</a></li> <li><a href="/wiki/Evans_blue_(dye)" title="Evans blue (dye)">Evans blue</a></li> <li><a href="/w/index.php?title=NS-3763&action=edit&redlink=1" class="new" title="NS-3763 (page does not exist)">NS-3763</a></li> <li><a href="/wiki/Pregnenolone_sulfate" title="Pregnenolone sulfate">Pregnenolone sulfate</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/N-Methyl-D-aspartate_receptor" class="mw-redirect" title="N-Methyl-D-aspartate receptor"><abbr title="N-Methyl-D-aspartate receptor">NMDAR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip N-Methyl-D-aspartate receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>Agonists:</b> <i>Main site agonists:</i> <a href="/w/index.php?title=2-Amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic_acid&action=edit&redlink=1" class="new" title="2-Amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (page does not exist)">AMAA</a></li> <li><a href="/wiki/Aspartate" class="mw-redirect" title="Aspartate">Aspartate</a></li> <li><a href="/wiki/Glutamate" class="mw-redirect" title="Glutamate">Glutamate</a></li> <li><a href="/wiki/Homocysteic_acid" title="Homocysteic acid">Homocysteic acid (<small>L</small>-HCA)</a></li> <li><a href="/wiki/Homoquinolinic_acid" title="Homoquinolinic acid">Homoquinolinic acid</a></li> <li><a href="/wiki/Ibotenic_acid" title="Ibotenic acid">Ibotenic acid</a></li> <li><a href="/wiki/N-Methyl-D-aspartic_acid" title="N-Methyl-D-aspartic acid">NMDA</a></li> <li><a href="/wiki/Proline" title="Proline">Proline</a></li> <li><a href="/wiki/Quinolinic_acid" title="Quinolinic acid">Quinolinic acid</a></li> <li><a href="/wiki/Tetrazolylglycine" title="Tetrazolylglycine">Tetrazolylglycine</a></li> <li><a href="/wiki/Theanine" title="Theanine">Theanine</a>; <i>Glycine site agonists:</i> <a href="/w/index.php?title=%CE%92-Fluoro-D-alanine&action=edit&redlink=1" class="new" title="Β-Fluoro-D-alanine (page does not exist)">β-Fluoro-<small>D</small>-alanine</a></li> <li><a href="/w/index.php?title=ACBD_(drug)&action=edit&redlink=1" class="new" title="ACBD (drug) (page does not exist)">ACBD</a></li> <li><a href="/wiki/1-Aminocyclopropanecarboxylic_acid" class="mw-redirect" title="1-Aminocyclopropanecarboxylic acid">ACC (ACPC)</a></li> <li><a href="/wiki/ACPD" title="ACPD">ACPD</a></li> <li><a href="/w/index.php?title=AK-51_(drug)&action=edit&redlink=1" class="new" title="AK-51 (drug) (page does not exist)">AK-51</a></li> <li><a href="/wiki/Apimostinel" title="Apimostinel">Apimostinel (NRX-1074)</a></li> <li><a href="/wiki/B6B21" class="mw-redirect" title="B6B21">B6B21</a></li> <li><a href="/w/index.php?title=Carboxycyclopropylglycine&action=edit&redlink=1" class="new" title="Carboxycyclopropylglycine (page does not exist)">CCG</a></li> <li><a href="/wiki/Alanine" title="Alanine"><small>D</small>-Alanine</a></li> <li><a href="/wiki/Cycloserine" title="Cycloserine"><small>D</small>-Cycloserine</a></li> <li><a href="/wiki/Serine" title="Serine"><small>D</small>-Serine</a></li> <li><a href="/w/index.php?title=N-(3,3-Diphenylpropyl)glycinamide&action=edit&redlink=1" class="new" title="N-(3,3-Diphenylpropyl)glycinamide (page does not exist)">DHPG</a></li> <li><a href="/wiki/Dimethylglycine" title="Dimethylglycine">Dimethylglycine</a></li> <li><a href="/wiki/Glycine" title="Glycine">Glycine</a></li> <li><a href="/wiki/HA-966" title="HA-966">HA-966</a></li> <li><a href="/w/index.php?title=L-687414&action=edit&redlink=1" class="new" title="L-687414 (page does not exist)">L-687414</a></li> <li><a href="/wiki/Alanine" title="Alanine"><small>L</small>-Alanine</a></li> <li><a href="/wiki/Serine" title="Serine"><small>L</small>-Serine</a></li> <li><a href="/wiki/Milacemide" title="Milacemide">Milacemide</a></li> <li><a href="/wiki/Neboglamine" title="Neboglamine">Neboglamine (nebostinel)</a></li> <li><a href="/wiki/Rapastinel" title="Rapastinel">Rapastinel (GLYX-13)</a></li> <li><a href="/wiki/Sarcosine" title="Sarcosine">Sarcosine</a>; <i>Polyamine site agonists:</i> <a href="/wiki/Neomycin" title="Neomycin">Neomycin</a></li> <li><a href="/wiki/Spermidine" title="Spermidine">Spermidine</a></li> <li><a href="/wiki/Spermine" title="Spermine">Spermine</a>; <i>Other positive allosteric modulators:</i> <a href="/wiki/24S-Hydroxycholesterol" title="24S-Hydroxycholesterol">24<i>S</i>-Hydroxycholesterol</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone"><abbr title="Dehydroepiandrosterone">DHEA</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Dehydroepiandrosterone</span> (<a href="/wiki/Prasterone" title="Prasterone">prasterone</a>)</li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate"><abbr title="Dehydroepiandrosterone">DHEA</abbr> sulfate</a> (<a href="/wiki/Prasterone_sulfate" title="Prasterone sulfate">prasterone sulfate</a>)</li> <li><a href="/w/index.php?title=Epipregnanolone_sulfate&action=edit&redlink=1" class="new" title="Epipregnanolone sulfate (page does not exist)">Epipregnanolone sulfate</a></li> <li><a href="/w/index.php?title=Plazinemdor&action=edit&redlink=1" class="new" title="Plazinemdor (page does not exist)">Plazinemdor</a></li> <li><a href="/wiki/Pregnenolone_sulfate" title="Pregnenolone sulfate">Pregnenolone sulfate</a></li> <li><a href="/w/index.php?title=SAGE-201&action=edit&redlink=1" class="new" title="SAGE-201 (page does not exist)">SAGE-201</a></li> <li><a href="/w/index.php?title=SAGE-301&action=edit&redlink=1" class="new" title="SAGE-301 (page does not exist)">SAGE-301</a></li> <li><a href="/wiki/SAGE-718" class="mw-redirect" title="SAGE-718">SAGE-718</a></li></ul> <ul><li><b>Antagonists:</b> <i>Competitive antagonists:</i> <a href="/wiki/AP5" title="AP5">AP5 (APV)</a></li> <li><a href="/wiki/AP-7_(drug)" title="AP-7 (drug)">AP7</a></li> <li><a href="/wiki/CGP-37849" title="CGP-37849">CGP-37849</a></li> <li><a href="/wiki/CGP-39551" title="CGP-39551">CGP-39551</a></li> <li><a href="/w/index.php?title=CGP-39653&action=edit&redlink=1" class="new" title="CGP-39653 (page does not exist)">CGP-39653</a></li> <li><a href="/w/index.php?title=CGP-40116&action=edit&redlink=1" class="new" title="CGP-40116 (page does not exist)">CGP-40116</a></li> <li><a href="/wiki/CGS-19755" class="mw-redirect" title="CGS-19755">CGS-19755</a></li> <li><a href="/w/index.php?title=3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic_acid&action=edit&redlink=1" class="new" title="3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (page does not exist)">CPP</a></li> <li><a href="/wiki/Kaitocephalin" title="Kaitocephalin">Kaitocephalin</a></li> <li><a href="/w/index.php?title=LY-233053&action=edit&redlink=1" class="new" title="LY-233053 (page does not exist)">LY-233053</a></li> <li><a href="/wiki/LY-235959" title="LY-235959">LY-235959</a></li> <li><a href="/w/index.php?title=LY-274614&action=edit&redlink=1" class="new" title="LY-274614 (page does not exist)">LY-274614</a></li> <li><a href="/w/index.php?title=MDL-100453&action=edit&redlink=1" class="new" title="MDL-100453 (page does not exist)">MDL-100453</a></li> <li><a href="/wiki/Midafotel" title="Midafotel">Midafotel (d-CPPene)</a></li> <li><a href="/w/index.php?title=NPC-12626&action=edit&redlink=1" class="new" title="NPC-12626 (page does not exist)">NPC-12626</a></li> <li><a href="/w/index.php?title=NPC-17742&action=edit&redlink=1" class="new" title="NPC-17742 (page does not exist)">NPC-17742</a></li> <li><a href="/w/index.php?title=PBPD&action=edit&redlink=1" class="new" title="PBPD (page does not exist)">PBPD</a></li> <li><a href="/wiki/PEAQX" title="PEAQX">PEAQX</a></li> <li><a href="/wiki/Perzinfotel" title="Perzinfotel">Perzinfotel</a></li> <li><a href="/w/index.php?title=Cis-1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic_acid&action=edit&redlink=1" class="new" title="Cis-1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid (page does not exist)">PPDA</a></li> <li><a href="/w/index.php?title=SDZ-220581&action=edit&redlink=1" class="new" title="SDZ-220581 (page does not exist)">SDZ-220581</a></li> <li><a href="/wiki/Selfotel" title="Selfotel">Selfotel</a>; <i>Glycine site antagonists:</i> <a href="/wiki/4-Chlorokynurenine" title="4-Chlorokynurenine">4-Cl-KYN (AV-101)</a></li> <li><a href="/wiki/5,7-Dichlorokynurenic_acid" title="5,7-Dichlorokynurenic acid">5,7-DCKA</a></li> <li><a href="/wiki/7-Chlorokynurenic_acid" title="7-Chlorokynurenic acid">7-CKA</a></li> <li><a href="/wiki/1-Aminocyclopropane-1-carboxylic_acid" title="1-Aminocyclopropane-1-carboxylic acid">ACC</a></li> <li><a href="/w/index.php?title=ACEA-1011&action=edit&redlink=1" class="new" title="ACEA-1011 (page does not exist)">ACEA-1011</a></li> <li><a href="/w/index.php?title=ACEA-1328&action=edit&redlink=1" class="new" title="ACEA-1328 (page does not exist)">ACEA-1328</a></li> <li><a href="/wiki/Apimostinel" title="Apimostinel">Apimostinel (NRX-1074)</a></li> <li><a href="/wiki/AV-101" class="mw-redirect" title="AV-101">AV-101</a></li> <li><a href="/wiki/Carisoprodol" title="Carisoprodol">Carisoprodol</a></li> <li><a href="/w/index.php?title=CGP-39653&action=edit&redlink=1" class="new" title="CGP-39653 (page does not exist)">CGP-39653</a></li> <li><a href="/wiki/CNQX" title="CNQX">CNQX</a></li> <li><a href="/wiki/Cycloserine" title="Cycloserine"><small>D</small>-Cycloserine</a></li> <li><a href="/wiki/DNQX" title="DNQX">DNQX</a></li> <li><a href="/wiki/Felbamate" title="Felbamate">Felbamate</a></li> <li><a href="/wiki/Gavestinel" title="Gavestinel">Gavestinel</a></li> <li><a href="/w/index.php?title=GV-196771&action=edit&redlink=1" class="new" title="GV-196771 (page does not exist)">GV-196771</a></li> <li><a href="/w/index.php?title=Harkoseride&action=edit&redlink=1" class="new" title="Harkoseride (page does not exist)">Harkoseride</a></li> <li><a href="/wiki/Kynurenic_acid" title="Kynurenic acid">Kynurenic acid</a></li> <li><a href="/wiki/Kynurenine" title="Kynurenine">Kynurenine</a></li> <li><a href="/w/index.php?title=L-689560&action=edit&redlink=1" class="new" title="L-689560 (page does not exist)">L-689560</a></li> <li><a href="/wiki/L-701324" title="L-701324">L-701324</a></li> <li><a href="/wiki/Licostinel" title="Licostinel">Licostinel (ACEA-1021)</a></li> <li><a href="/w/index.php?title=LU-73068&action=edit&redlink=1" class="new" title="LU-73068 (page does not exist)">LU-73068</a></li> <li><a href="/w/index.php?title=MDL-105519&action=edit&redlink=1" class="new" title="MDL-105519 (page does not exist)">MDL-105519</a></li> <li><a href="/wiki/Meprobamate" title="Meprobamate">Meprobamate</a></li> <li><a href="/w/index.php?title=MRZ_2/576&action=edit&redlink=1" class="new" title="MRZ 2/576 (page does not exist)">MRZ 2/576</a></li> <li><a href="/w/index.php?title=PNQX&action=edit&redlink=1" class="new" title="PNQX (page does not exist)">PNQX</a></li> <li><a href="/wiki/Rapastinel" title="Rapastinel">Rapastinel (GLYX-13)</a></li> <li><a href="/wiki/ZD-9379" title="ZD-9379">ZD-9379</a>; <i>Polyamine site antagonists:</i> <a href="/w/index.php?title=Arcaine&action=edit&redlink=1" class="new" title="Arcaine (page does not exist)">Arcaine</a></li> <li><a href="/w/index.php?title=Co_101676&action=edit&redlink=1" class="new" title="Co 101676 (page does not exist)">Co 101676</a></li> <li><a href="/wiki/1,3-Diaminopropane" title="1,3-Diaminopropane">Diaminopropane</a></li> <li><a href="/wiki/Diethylenetriamine" title="Diethylenetriamine">Diethylenetriamine</a></li> <li><a href="/wiki/Huperzine_A" title="Huperzine A">Huperzine A</a></li> <li><a href="/wiki/Putrescine" title="Putrescine">Putrescine</a>; <i>Uncompetitive pore blockers (mostly dizocilpine site):</i> <a href="/wiki/2-MDP" title="2-MDP">2-MDP</a></li> <li><a href="/wiki/3-HO-PCP" title="3-HO-PCP">3-HO-PCP</a></li> <li><a href="/wiki/3-MeO-PCE" title="3-MeO-PCE">3-MeO-PCE</a></li> <li><a href="/wiki/3-MeO-PCMo" title="3-MeO-PCMo">3-MeO-PCMo</a></li> <li><a href="/wiki/3-MeO-PCP" title="3-MeO-PCP">3-MeO-PCP</a></li> <li><a href="/wiki/4-MeO-PCP" title="4-MeO-PCP">4-MeO-PCP</a></li> <li><a href="/wiki/8a-Phenyldecahydroquinoline" class="mw-redirect" title="8a-Phenyldecahydroquinoline">8A-PDHQ</a></li> <li><a href="/wiki/18-Methoxycoronaridine" title="18-Methoxycoronaridine">18-MC</a></li> <li><a href="/wiki/Alpha-Endopsychosin" class="mw-redirect" title="Alpha-Endopsychosin">α-Endopsychosin</a></li> <li><a href="/wiki/Alaproclate" title="Alaproclate">Alaproclate</a></li> <li><a href="/wiki/Alazocine" title="Alazocine">Alazocine (SKF-10047)</a></li> <li><a href="/wiki/Amantadine" title="Amantadine">Amantadine</a></li> <li><a href="/wiki/Aptiganel" title="Aptiganel">Aptiganel</a></li> <li><a href="/w/index.php?title=Argiotoxin-636&action=edit&redlink=1" class="new" title="Argiotoxin-636 (page does not exist)">Argiotoxin-636</a></li> <li><a href="/wiki/Arketamine" title="Arketamine">Arketamine</a></li> <li><a href="/w/index.php?title=ARL-12495&action=edit&redlink=1" class="new" title="ARL-12495 (page does not exist)">ARL-12495</a></li> <li><a href="/wiki/ARL-15896-AR" class="mw-redirect" title="ARL-15896-AR">ARL-15896-AR</a></li> <li><a href="/wiki/ARL-16247" class="mw-redirect" title="ARL-16247">ARL-16247</a></li> <li><a href="/wiki/Budipine" title="Budipine">Budipine</a></li> <li><a href="/wiki/Coronaridine" title="Coronaridine">Coronaridine</a></li> <li><a href="/wiki/Delucemine" title="Delucemine">Delucemine (NPS-1506)</a></li> <li><a href="/wiki/Dexoxadrol" title="Dexoxadrol">Dexoxadrol</a></li> <li><a href="/wiki/Dextrallorphan" title="Dextrallorphan">Dextrallorphan</a></li> <li><a href="/wiki/Dextromethadone" class="mw-redirect" title="Dextromethadone">Dextromethadone</a></li> <li><a href="/wiki/Dextromethorphan" title="Dextromethorphan">Dextromethorphan</a></li> <li><a href="/wiki/Dextrorphan" title="Dextrorphan">Dextrorphan</a></li> <li><a href="/wiki/Dieticyclidine" title="Dieticyclidine">Dieticyclidine</a></li> <li><a href="/wiki/Diphenidine" title="Diphenidine">Diphenidine</a></li> <li><a href="/wiki/Dizocilpine" title="Dizocilpine">Dizocilpine</a></li> <li><a href="/wiki/Ephenidine" title="Ephenidine">Ephenidine</a></li> <li><a href="/wiki/Esketamine" title="Esketamine">Esketamine</a></li> <li><a href="/wiki/Etoxadrol" title="Etoxadrol">Etoxadrol</a></li> <li><a href="/wiki/Eticyclidine" title="Eticyclidine">Eticyclidine</a></li> <li><a href="/wiki/Fluorolintane" title="Fluorolintane">Fluorolintane</a></li> <li><a href="/wiki/Gacyclidine" title="Gacyclidine">Gacyclidine</a></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/Ibogamine" title="Ibogamine">Ibogamine</a></li> <li><a href="/wiki/Indantadol" title="Indantadol">Indantadol</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/Ketobemidone" title="Ketobemidone">Ketobemidone</a></li> <li><a href="/wiki/Lanicemine" title="Lanicemine">Lanicemine</a></li> <li><a href="/wiki/Levomethadone" title="Levomethadone">Levomethadone</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levomilnacipran" title="Levomilnacipran">Levomilnacipran</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/wiki/Loperamide" title="Loperamide">Loperamide</a></li> <li><a href="/wiki/Memantine" title="Memantine">Memantine</a></li> <li><a href="/wiki/Methadone" title="Methadone">Methadone</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Methorphan</a></li> <li><a href="/wiki/Methoxetamine" title="Methoxetamine">Methoxetamine</a></li> <li><a href="/wiki/Methoxphenidine" title="Methoxphenidine">Methoxphenidine</a></li> <li><a href="/wiki/Milnacipran" title="Milnacipran">Milnacipran</a></li> <li><a href="/wiki/Morphanol" class="mw-redirect" title="Morphanol">Morphanol</a></li> <li><a href="/wiki/NEFA_(drug)" title="NEFA (drug)">NEFA</a></li> <li><a href="/wiki/Neramexane" title="Neramexane">Neramexane</a></li> <li><a href="/wiki/Nitromemantine" title="Nitromemantine">Nitromemantine</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Norketamine" title="Norketamine">Norketamine</a></li> <li><a href="/wiki/Orphenadrine" title="Orphenadrine">Orphenadrine</a></li> <li><a href="/wiki/PCPr" title="PCPr">PCPr</a></li> <li><a href="/wiki/PD-137889" title="PD-137889">PD-137889</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Phencyclamine" class="mw-redirect" title="Phencyclamine">Phencyclamine</a></li> <li><a href="/wiki/Phencyclidine" title="Phencyclidine">Phencyclidine</a></li> <li><a href="/wiki/Propoxyphene" class="mw-redirect" title="Propoxyphene">Propoxyphene</a></li> <li><a href="/wiki/Remacemide" title="Remacemide">Remacemide</a></li> <li><a href="/wiki/Rhynchophylline" title="Rhynchophylline">Rhynchophylline</a></li> <li><a href="/wiki/Rimantadine" title="Rimantadine">Rimantadine</a></li> <li><a href="/wiki/Rolicyclidine" title="Rolicyclidine">Rolicyclidine</a></li> <li><a href="/wiki/Sabeluzole" title="Sabeluzole">Sabeluzole</a></li> <li><a href="/wiki/Tabernanthine" title="Tabernanthine">Tabernanthine</a></li> <li><a href="/wiki/Tenocyclidine" title="Tenocyclidine">Tenocyclidine</a></li> <li><a href="/wiki/Tiletamine" title="Tiletamine">Tiletamine</a></li> <li><a href="/wiki/Tramadol" title="Tramadol">Tramadol</a>; <i>Ifenprodil (NR2B) site antagonists:</i></li> <li><a href="/wiki/Besonprodil" title="Besonprodil">Besonprodil</a></li> <li><a href="/wiki/Buphenine" title="Buphenine">Buphenine (nylidrin)</a></li> <li><a href="/w/index.php?title=CO-101244&action=edit&redlink=1" class="new" title="CO-101244 (page does not exist)">CO-101244 (PD-174494)</a></li> <li><a href="/wiki/Eliprodil" title="Eliprodil">Eliprodil</a></li> <li><a href="/wiki/Haloperidol" title="Haloperidol">Haloperidol</a></li> <li><a href="/wiki/Isoxsuprine" title="Isoxsuprine">Isoxsuprine</a></li> <li><a href="/w/index.php?title=Radiprodil&action=edit&redlink=1" class="new" title="Radiprodil (page does not exist)">Radiprodil (RGH-896)</a></li> <li><a href="/wiki/Rislenemdaz" title="Rislenemdaz">Rislenemdaz (CERC-301, MK-0657)</a></li> <li><a href="/w/index.php?title=Ro_8-4304&action=edit&redlink=1" class="new" title="Ro 8-4304 (page does not exist)">Ro 8-4304</a></li> <li><a href="/w/index.php?title=Ro_25-6981&action=edit&redlink=1" class="new" title="Ro 25-6981 (page does not exist)">Ro 25-6981</a></li> <li><a href="/wiki/Safaprodil" class="mw-redirect" title="Safaprodil">Safaprodil</a></li> <li><a href="/wiki/Traxoprodil" title="Traxoprodil">Traxoprodil (CP-101606)</a>; <i>NR2A-selective antagonists:</i> <a href="/w/index.php?title=MPX-004&action=edit&redlink=1" class="new" title="MPX-004 (page does not exist)">MPX-004</a></li> <li><a href="/w/index.php?title=MPX-007&action=edit&redlink=1" class="new" title="MPX-007 (page does not exist)">MPX-007</a></li> <li><a href="/w/index.php?title=TCN-201&action=edit&redlink=1" class="new" title="TCN-201 (page does not exist)">TCN-201</a></li> <li><a href="/w/index.php?title=TCN-213&action=edit&redlink=1" class="new" title="TCN-213 (page does not exist)">TCN-213</a>; <i>Cations:</i> <a href="/wiki/Hydrogen" title="Hydrogen">Hydrogen</a></li> <li><a href="/wiki/Magnesium" title="Magnesium">Magnesium</a></li> <li><a href="/wiki/Zinc" title="Zinc">Zinc</a>; <i>Alcohols/volatile anesthetics/related:</i> <a href="/wiki/Benzene" title="Benzene">Benzene</a></li> <li><a href="/wiki/Butane" title="Butane">Butane</a></li> <li><a href="/wiki/Chloroform" title="Chloroform">Chloroform</a></li> <li><a href="/wiki/Cyclopropane" title="Cyclopropane">Cyclopropane</a></li> <li><a href="/wiki/Desflurane" title="Desflurane">Desflurane</a></li> <li><a href="/wiki/Diethyl_ether" title="Diethyl ether">Diethyl ether</a></li> <li><a href="/wiki/Enflurane" title="Enflurane">Enflurane</a></li> <li><a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">Ethanol (alcohol)</a></li> <li><a href="/wiki/Halothane" title="Halothane">Halothane</a></li> <li><a href="/wiki/Hexanol" title="Hexanol">Hexanol</a></li> <li><a href="/wiki/Isoflurane" title="Isoflurane">Isoflurane</a></li> <li><a href="/wiki/Methoxyflurane" title="Methoxyflurane">Methoxyflurane</a></li> <li><a href="/wiki/Nitrous_oxide" title="Nitrous oxide">Nitrous oxide</a></li> <li><a href="/wiki/Octanol" title="Octanol">Octanol</a></li> <li><a href="/wiki/Sevoflurane" title="Sevoflurane">Sevoflurane</a></li> <li><a href="/wiki/Toluene" title="Toluene">Toluene</a></li> <li><a href="/wiki/1,1,1-Trichloroethane" title="1,1,1-Trichloroethane">Trichloroethane</a></li> <li><a href="/wiki/2,2,2-Trichloroethanol" title="2,2,2-Trichloroethanol">Trichloroethanol</a></li> <li><a href="/wiki/Trichloroethylene" title="Trichloroethylene">Trichloroethylene</a></li> <li><a href="/wiki/Ethyl_carbamate" title="Ethyl carbamate">Urethane</a></li> <li><a href="/wiki/Xenon" title="Xenon">Xenon</a></li> <li><a href="/wiki/Xylene" title="Xylene">Xylene</a>; <i>Unknown/unsorted antagonists:</i> <a href="/w/index.php?title=ARR-15896&action=edit&redlink=1" class="new" title="ARR-15896 (page does not exist)">ARR-15896</a></li> <li><a href="/wiki/Bumetanide" title="Bumetanide">Bumetanide</a></li> <li><a href="/wiki/Caroverine" title="Caroverine">Caroverine</a></li> <li><a href="/wiki/Conantokin" title="Conantokin">Conantokin</a></li> <li><a href="/wiki/D-%CE%B1-Aminoadipate" class="mw-redirect" title="D-α-Aminoadipate"><small>D</small>-αAA</a></li> <li><a href="/wiki/Dexanabinol" title="Dexanabinol">Dexanabinol</a></li> <li><a href="/wiki/Flufenamic_acid" title="Flufenamic acid">Flufenamic acid</a></li> <li><a href="/wiki/Flupirtine" title="Flupirtine">Flupirtine</a></li> <li><a href="/w/index.php?title=FPL-12495&action=edit&redlink=1" class="new" title="FPL-12495 (page does not exist)">FPL-12495</a></li> <li><a href="/w/index.php?title=FR-115427&action=edit&redlink=1" class="new" title="FR-115427 (page does not exist)">FR-115427</a></li> <li><a href="/wiki/Furosemide" title="Furosemide">Furosemide</a></li> <li><a href="/wiki/Hodgkinsine" title="Hodgkinsine">Hodgkinsine</a></li> <li><a href="/w/index.php?title=Ipenoxazone&action=edit&redlink=1" class="new" title="Ipenoxazone (page does not exist)">Ipenoxazone (MLV-6976)</a></li> <li><a href="/w/index.php?title=MDL-27266&action=edit&redlink=1" class="new" title="MDL-27266 (page does not exist)">MDL-27266</a></li> <li><a href="/wiki/Metaphit" title="Metaphit">Metaphit</a></li> <li><a href="/wiki/Minocycline" title="Minocycline">Minocycline</a></li> <li><a href="/wiki/2-Methyl-6-(phenylethynyl)pyridine" title="2-Methyl-6-(phenylethynyl)pyridine">MPEP</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid</a></li> <li><a href="/wiki/Pentamidine" title="Pentamidine">Pentamidine</a></li> <li><a href="/wiki/Pentamidine_isethionate" class="mw-redirect" title="Pentamidine isethionate">Pentamidine isethionate</a></li> <li><a href="/wiki/Piretanide" title="Piretanide">Piretanide</a></li> <li><a href="/wiki/Psychotridine" title="Psychotridine">Psychotridine</a></li> <li><a href="/wiki/Transcrocetin" class="mw-redirect" title="Transcrocetin">Transcrocetin</a> (<a href="/wiki/Saffron" title="Saffron">saffron</a>)</li></ul> <ul><li><b>Unsorted:</b> <i>Allosteric modulators:</i> <a href="/wiki/AGN-241751" class="mw-redirect" title="AGN-241751">AGN-241751</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <ul><li><i><b>See also:</b> <a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></i></li> <li><i><a href="/wiki/Template:Metabotropic_glutamate_receptor_modulators" title="Template:Metabotropic glutamate receptor modulators">Metabotropic glutamate receptor modulators</a></i></li> <li><i><a href="/wiki/Template:Glutamate_metabolism_and_transport_modulators" title="Template:Glutamate metabolism and transport modulators">Glutamate metabolism/transport modulators</a></i></li></ul> 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