Journal of Personalized Medicine | An Open Access Journal from MDPI

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value="civileng" > CivilEng </option> <option value="cleantechnol" > Clean Technologies (Clean Technol.) </option> <option value="climate" > Climate </option> <option value="ctn" > Clinical and Translational Neuroscience (CTN) </option> <option value="clinbioenerg" > Clinical Bioenergetics </option> <option value="clinpract" > Clinics and Practice </option> <option value="clockssleep" > Clocks & Sleep </option> <option value="coasts" > Coasts </option> <option value="coatings" > Coatings </option> <option value="colloids" > Colloids and Interfaces </option> <option value="colorants" > Colorants </option> <option value="commodities" > Commodities </option> <option value="complications" > Complications </option> <option value="compounds" > Compounds </option> <option value="computation" > Computation </option> <option value="csmf" > Computer Sciences & Mathematics Forum </option> <option value="computers" > Computers </option> <option value="condensedmatter" > Condensed Matter </option> 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Medicine </option> <option value="encyclopedia" > Encyclopedia </option> <option value="endocrines" > Endocrines </option> <option value="energies" > Energies </option> <option value="esa" > Energy Storage and Applications (ESA) </option> <option value="eng" > Eng </option> <option value="engproc" > Engineering Proceedings </option> <option value="entropy" > Entropy </option> <option value="eesp" > Environmental and Earth Sciences Proceedings </option> <option value="environments" > Environments </option> <option value="epidemiologia" > Epidemiologia </option> <option value="epigenomes" > Epigenomes </option> <option value="ebj" > European Burn Journal (EBJ) </option> <option value="ejihpe" > European Journal of Investigation in Health, Psychology and Education (EJIHPE) </option> <option value="fermentation" > Fermentation </option> <option value="fibers" > Fibers </option> <option value="fintech" > FinTech </option> <option value="fire" > Fire </option> <option value="fishes" > Fishes 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Research and Public Health (IJERPH) </option> <option value="ijfs" > International Journal of Financial Studies (IJFS) </option> <option value="ijms" > International Journal of Molecular Sciences (IJMS) </option> <option value="IJNS" > International Journal of Neonatal Screening (IJNS) </option> <option value="ijom" > International Journal of Orofacial Myology and Myofunctional Therapy (IJOM) </option> <option value="ijpb" > International Journal of Plant Biology (IJPB) </option> <option value="ijt" > International Journal of Topology </option> <option value="ijtm" > International Journal of Translational Medicine (IJTM) </option> <option value="ijtpp" > International Journal of Turbomachinery, Propulsion and Power (IJTPP) </option> <option value="ime" > International Medical Education (IME) </option> <option value="inventions" > Inventions </option> <option value="IoT" > IoT </option> <option value="ijgi" > ISPRS International Journal of Geo-Information (IJGI) </option> <option value="J" > J </option> <option value="jal" > Journal of Ageing and Longevity (JAL) </option> <option value="jcdd" > Journal of Cardiovascular Development and Disease (JCDD) </option> <option value="jcto" > Journal of Clinical & Translational Ophthalmology (JCTO) </option> <option value="jcm" > Journal of Clinical Medicine (JCM) </option> <option value="jcs" > Journal of Composites Science (J. Compos. Sci.) </option> <option value="jcp" > Journal of Cybersecurity and Privacy (JCP) </option> <option value="jdad" > Journal of Dementia and Alzheimer's Disease (JDAD) </option> <option value="jdb" > Journal of Developmental Biology (JDB) </option> <option value="jeta" > Journal of Experimental and Theoretical Analyses (JETA) </option> <option value="jemr" > Journal of Eye Movement Research (JEMR) </option> <option value="jfb" > Journal of Functional Biomaterials (JFB) </option> <option value="jfmk" > Journal of Functional Morphology and Kinesiology (JFMK) </option> <option value="jof" > Journal of Fungi (JoF) </option> <option value="jimaging" > Journal of Imaging (J. Imaging) </option> <option value="jintelligence" > Journal of Intelligence (J. Intell.) </option> <option value="jlpea" > Journal of Low Power Electronics and Applications (JLPEA) </option> <option value="jmmp" > Journal of Manufacturing and Materials Processing (JMMP) </option> <option value="jmse" > Journal of Marine Science and Engineering (JMSE) </option> <option value="jmahp" > Journal of Market Access & Health Policy (JMAHP) </option> <option value="jmms" > Journal of Mind and Medical Sciences (JMMS) </option> <option value="jmp" > Journal of Molecular Pathology (JMP) </option> <option value="jnt" > Journal of Nanotheranostics (JNT) </option> <option value="jne" > Journal of Nuclear Engineering (JNE) </option> <option value="ohbm" > Journal of Otorhinolaryngology, Hearing and Balance Medicine (JOHBM) </option> <option value="jop" > Journal of Parks </option> <option value="jpm" selected='selected'> Journal of Personalized Medicine (JPM) </option> <option value="jpbi" > Journal of Pharmaceutical and BioTech Industry (JPBI) </option> <option value="jor" > Journal of Respiration (JoR) </option> <option value="jrfm" > Journal of Risk and Financial Management (JRFM) </option> <option value="jsan" > Journal of Sensor and Actuator Networks (JSAN) </option> <option value="joma" > Journal of the Oman Medical Association (JOMA) </option> <option value="jtaer" > Journal of Theoretical and Applied Electronic Commerce Research (JTAER) </option> <option value="jvd" > Journal of Vascular Diseases (JVD) </option> <option value="jox" > Journal of Xenobiotics (JoX) </option> <option value="jzbg" > Journal of Zoological and Botanical Gardens (JZBG) </option> <option value="journalmedia" > Journalism and Media </option> <option value="kidneydial" > Kidney and Dialysis </option> <option value="kinasesphosphatases" > Kinases and Phosphatases </option> <option value="knowledge" > Knowledge </option> <option value="labmed" > LabMed </option> <option value="laboratories" > Laboratories </option> <option value="land" > Land </option> <option value="languages" > Languages </option> <option value="laws" > Laws </option> <option value="life" > Life </option> <option value="limnolrev" > Limnological Review </option> <option value="lipidology" > Lipidology </option> <option value="liquids" > Liquids </option> <option value="literature" > Literature </option> <option value="livers" > Livers </option> <option value="logics" > Logics </option> <option value="logistics" > Logistics </option> <option value="lubricants" > Lubricants </option> <option value="lymphatics" > Lymphatics </option> <option value="make" > Machine Learning and Knowledge Extraction (MAKE) </option> <option value="machines" > Machines </option> <option value="macromol" > Macromol </option> <option value="magnetism" > Magnetism </option> <option value="magnetochemistry" > Magnetochemistry </option> <option value="marinedrugs" > Marine Drugs </option> <option value="materials" > Materials </option> <option value="materproc" > Materials Proceedings </option> <option value="mca" > Mathematical and Computational Applications (MCA) </option> <option value="mathematics" > Mathematics </option> <option value="medsci" > Medical Sciences </option> <option value="msf" > Medical Sciences Forum </option> <option value="medicina" > Medicina </option> <option value="medicines" > Medicines </option> <option value="membranes" > Membranes </option> <option value="merits" > Merits </option> <option value="metabolites" > Metabolites </option> <option value="metals" > Metals </option> <option value="meteorology" > Meteorology </option> <option value="methane" > Methane </option> <option value="mps" > Methods and Protocols (MPs) </option> <option value="metrics" > Metrics </option> <option value="metrology" > Metrology </option> <option value="micro" > Micro </option> <option value="microbiolres" > Microbiology Research </option> <option value="micromachines" > Micromachines </option> <option value="microorganisms" > Microorganisms </option> <option value="microplastics" > Microplastics </option> <option value="microwave" > Microwave </option> <option value="minerals" > Minerals </option> <option value="mining" > Mining </option> <option value="modelling" > Modelling </option> <option value="mmphys" > Modern Mathematical Physics </option> <option value="molbank" > Molbank </option> <option value="molecules" > Molecules </option> <option value="mti" > Multimodal Technologies and Interaction (MTI) </option> <option value="muscles" > Muscles </option> <option value="nanoenergyadv" > Nanoenergy Advances </option> <option value="nanomanufacturing" > Nanomanufacturing </option> <option value="nanomaterials" > Nanomaterials </option> <option value="ndt" > NDT </option> <option value="network" > Network </option> <option value="neuroglia" > Neuroglia </option> <option value="neurolint" > Neurology International </option> <option value="neurosci" > NeuroSci </option> <option value="nitrogen" > Nitrogen </option> <option value="ncrna" > Non-Coding RNA (ncRNA) </option> <option value="nursrep" > Nursing Reports </option> <option value="nutraceuticals" > Nutraceuticals </option> <option value="nutrients" > Nutrients </option> <option value="obesities" > Obesities </option> <option value="oceans" > Oceans </option> <option value="onco" > Onco </option> <option value="optics" > Optics </option> <option value="oral" > Oral </option> <option value="organics" > Organics </option> <option value="organoids" > Organoids </option> <option value="osteology" > Osteology </option> <option value="oxygen" > Oxygen </option> <option value="parasitologia" > Parasitologia </option> <option value="particles" > Particles </option> <option value="pathogens" > Pathogens </option> <option value="pathophysiology" > Pathophysiology </option> <option value="pediatrrep" > Pediatric Reports </option> <option value="pets" > Pets </option> <option value="pharmaceuticals" > Pharmaceuticals </option> <option value="pharmaceutics" > Pharmaceutics </option> <option value="pharmacoepidemiology" > Pharmacoepidemiology </option> <option value="pharmacy" > Pharmacy </option> <option value="philosophies" > Philosophies </option> <option value="photochem" > Photochem </option> <option value="photonics" > Photonics </option> <option value="phycology" > Phycology </option> <option value="physchem" > Physchem </option> <option value="psf" > Physical Sciences Forum </option> <option value="physics" > Physics </option> <option value="physiologia" > Physiologia </option> <option value="plants" > Plants </option> <option value="plasma" > Plasma </option> <option value="platforms" > Platforms </option> <option value="pollutants" > Pollutants </option> <option value="polymers" > Polymers </option> <option value="polysaccharides" > Polysaccharides </option> <option value="populations" > Populations </option> <option value="poultry" > Poultry </option> <option value="powders" > Powders </option> <option value="proceedings" > Proceedings </option> <option 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value="remotesensing" > Remote Sensing </option> <option value="reports" > Reports </option> <option value="reprodmed" > Reproductive Medicine (Reprod. Med.) </option> <option value="resources" > Resources </option> <option value="rheumato" > Rheumato </option> <option value="risks" > Risks </option> <option value="robotics" > Robotics </option> <option value="ruminants" > Ruminants </option> <option value="safety" > Safety </option> <option value="sci" > Sci </option> <option value="scipharm" > Scientia Pharmaceutica (Sci. Pharm.) </option> <option value="sclerosis" > Sclerosis </option> <option value="seeds" > Seeds </option> <option value="sensors" > Sensors </option> <option value="separations" > Separations </option> <option value="sexes" > Sexes </option> <option value="signals" > Signals </option> <option value="sinusitis" > Sinusitis </option> <option value="smartcities" > Smart Cities </option> <option value="socsci" > Social Sciences </option> <option value="siuj" > Société Internationale d’Urologie Journal (SIUJ) </option> <option value="societies" > Societies </option> <option value="software" > Software </option> <option value="soilsystems" > Soil Systems </option> <option value="solar" > Solar </option> <option value="solids" > Solids </option> <option value="spectroscj" > Spectroscopy Journal </option> <option value="sports" > Sports </option> <option value="standards" > Standards </option> <option value="stats" > Stats </option> <option value="stresses" > Stresses </option> <option value="surfaces" > Surfaces </option> <option value="surgeries" > Surgeries </option> <option value="std" > Surgical Techniques Development </option> <option value="sustainability" > Sustainability </option> <option value="suschem" > Sustainable Chemistry </option> <option value="symmetry" > Symmetry </option> <option value="synbio" > SynBio </option> <option value="systems" > Systems </option> <option value="targets" > Targets </option> <option value="taxonomy" > Taxonomy </option> <option value="technologies" > Technologies </option> <option value="telecom" > Telecom </option> <option value="textiles" > Textiles </option> <option value="thalassrep" > Thalassemia Reports </option> <option value="therapeutics" > Therapeutics </option> <option value="thermo" > Thermo </option> <option value="timespace" > Time and Space </option> <option value="tomography" > Tomography </option> <option value="tourismhosp" > Tourism and Hospitality </option> <option value="toxics" > Toxics </option> 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content__container--overflow-initial"> <div class="custom-accordion-for-small-screen-link active"> <h2 class="no-padding-left">Latest Articles</h2> </div> <div class="custom-accordion-for-small-screen-content"> <div class="expanding-div collapsed"> <div class="generic-item article-item no-border"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1599124" aria-controls="drop-supplementary-1599124" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1599124" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2075-4426/15/3/83/s1?version=1740476754"> Supplementary File 1 (ZIP, 846 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 14 pages, 1102 KiB   </span> <a href="/2075-4426/15/3/83/pdf?version=1740476753" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Sex-Specific Associations Between Dynapenia and Risk of Atherosclerotic Cardiovascular Disease: A Machine-Learning-Based Approach" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2075-4426/15/3/83">Sex-Specific Associations Between Dynapenia and Risk of Atherosclerotic Cardiovascular Disease: A Machine-Learning-Based Approach</a> <div class="authors"> by <span class="inlineblock "><strong>Gyumin Lee</strong>, </span><span class="inlineblock "><strong>Hye-Jin Kim</strong>, </span><span class="inlineblock "><strong>Heeji Choi</strong>, </span><span class="inlineblock "><strong>Seung-Ho Shin</strong>, </span><span class="inlineblock "><strong>Chulho Kim</strong>, </span><span class="inlineblock "><strong>Sang-Hwa Lee</strong>, </span><span class="inlineblock "><strong>Jong-Hee Sohn</strong> and </span><span class="inlineblock "><strong>Jae Jun Lee</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(3), 83; https://doi.org/10.3390/jpm15030083 (registering DOI) - 25 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives</b>: Dynapenia, age-associated loss in muscle strength, is an emerging risk factor for atherosclerotic cardiovascular disease (ASCVD), which may have different effects depending on sex. This study aims to investigate the association between dynapenia and ASCVD risk, evaluate its predictive significance among <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/3/83/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives</b>: Dynapenia, age-associated loss in muscle strength, is an emerging risk factor for atherosclerotic cardiovascular disease (ASCVD), which may have different effects depending on sex. This study aims to investigate the association between dynapenia and ASCVD risk, evaluate its predictive significance among traditional factors, and explore sex-specific patterns through machine learning models. <b>Methods</b>: This retrospective case–control study uses data from 19,582 participants aged 40–79 from the Korean National Health and Nutrition Examination Survey (KNHANES). ASCVD risk is assessed using the American College of Cardiology/American Heart Association 10-year risk algorithm, with dynapenia defined based on hand grip strength. Multivariable logistic regression and ML algorithms, including light gradient boosting (LGB) and XGBoost (XGB), are applied to examine predictive factors. Model performance is evaluated via the area under the receiver operating characteristic curve (AUROC), and Shapley additive explanation (SHAP) analysis highlights variable importance. <b>Results</b>: Dynapenia prevalence is higher in women (33.4%) than men (13.9%) at high ASCVD risk. Logistic regression shows dynapenia is significantly associated with high ASCVD risk in women (odds ratio, 1.47; 95% confidence interval, 1.20–1.81) but not in men. Machine learning models demonstrate excellent predictive performance, with XGB achieving the highest AUROC (0.950 in men and 0.963 in women). The SHAP analysis identifies dynapenia as a critical risk factor in women, while body mass index, educational status, and household income are influential in both sexes. <b>Conclusions</b>: Dynapenia is a significant ASCVD risk factor in women, emphasizing sex-specific prevention strategies. Machine learning enhances risk assessment precision, underscoring muscle health’s role in cardiovascular care. <a href="/2075-4426/15/3/83">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jpm/sections/sex_gender_hormone_based_medicine">Sex, Gender and Hormone Based Medicine</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2075-4426/15/3/83/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1599124"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1599124"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1599124" data-cycle-prev="#prev1599124" data-cycle-progressive="#images1599124" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1599124-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jpm/jpm-15-00083/article_deploy/html/images/jpm-15-00083-g001-550.jpg?1740476903" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1599124" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1599124-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00083/article_deploy/html/images/jpm-15-00083-g002-550.jpg?1740476904'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1599124-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00083/article_deploy/html/images/jpm-15-00083-g003-550.jpg?1740476904'><p>Figure 3</p></div></script></div></div><div id="article-1599124-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jpm/jpm-15-00083/article_deploy/html/images/jpm-15-00083-g001-550.jpg?1740476903" title=" <strong>Figure 1</strong><br/> <p>Flow chart of study participants. KNHANES, Korean National Health and Nutrition Examination Survey; CVD, cardiovascular disease; ASCVD, atherosclerotic cardiovascular disease.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/83'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00083/article_deploy/html/images/jpm-15-00083-g002-550.jpg?1740476904" title=" <strong>Figure 2</strong><br/> <p>Model performance in predicting high atherosclerotic cardiovascular disease risk in men (<b>a</b>) and women (<b>b</b>) presented as area under the receiver operating characteristic curve. LR, logistic regression; SVM, support vector machine; RF, random forest; XGB, extreme gradient boosting; LGB, light gradient boosting.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/83'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00083/article_deploy/html/images/jpm-15-00083-g003-550.jpg?1740476904" title=" <strong>Figure 3</strong><br/> <p>Shapley additive explanation (SHAP) values in ML models for high atherosclerotic cardiovascular disease risk prediction according to sex. Feature importance plot in men (<b>a</b>) and in women (<b>c</b>). SHAP summary plot of extreme gradient boosting model in men (<b>b</b>) and women (<b>d</b>).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/83'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="extending-content content-ready"> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 11 pages, 214 KiB   </span> <a href="/2075-4426/15/3/82/pdf?version=1740476064" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="The Influence of a Specialized Dementia Ward on the Treatment of Alzheimer’s Disease Patients" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2075-4426/15/3/82">The Influence of a Specialized Dementia Ward on the Treatment of Alzheimer’s Disease Patients</a> <div class="authors"> by <span class="inlineblock "><strong>Youngsoon Yang</strong>, </span><span class="inlineblock "><strong>Kyoon Huh</strong> and </span><span class="inlineblock "><strong>Yong Tae Kwak</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(3), 82; https://doi.org/10.3390/jpm15030082 (registering DOI) - 25 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Hospitalization for severe neuropsychiatric symptoms in Alzheimer’s disease (AD) presents challenges, often requiring environments that ensure safety while addressing therapeutic needs. Traditional closed wards, originally designed for psychiatric conditions like schizophrenia, may not fully address the unique needs of AD patients. This <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/3/82/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Hospitalization for severe neuropsychiatric symptoms in Alzheimer’s disease (AD) presents challenges, often requiring environments that ensure safety while addressing therapeutic needs. Traditional closed wards, originally designed for psychiatric conditions like schizophrenia, may not fully address the unique needs of AD patients. This study evaluates the effectiveness of a Specialized Dementia Ward (SDW) tailored for AD patients compared to a General Ward (GW). <b>Methods:</b> A retrospective study compared 51 AD patients in an SDW (February 2018–January 2019) and 40 AD patients in a GW (December 2017–January 2018). Patients met NINCDS-ADRDA criteria, with a Clinical Dementia Rating (CDR) ≤ 2 and a Korean Mini-Mental State Examination (K-MMSE) ≤ 20. Clinical assessments at admission and four weeks included K-MMSE, Resident Assessment Instrument Minimum Data Set Version 2.0 (RAI-MDS), and Neuropsychiatric Inventory Questionnaire (NPI-Q). Psychotropic medication use, length of stay, and discharge destination were also analyzed. <b>Results:</b> No statistically significant differences emerged between SDW and GW groups regarding baseline demographics, cognitive function, ADL, or neuropsychiatric symptoms. At four weeks, both groups exhibited trends toward improved K-MMSE, RAI-MDS, and NPI-Q scores and reduced psychotropic usage, but these did not reach statistical significance. Although mean length of stay was shorter for SDW patients (3.2 vs. 4.9 months; <i>p</i> = 0.078), the difference was not significant. Notably, a significantly higher proportion of SDW patients were discharged home (58.8% vs. 37.5%; <i>p</i> = 0.049). <b>Conclusions:</b> Although clinical outcomes were comparable, the SDW demonstrated advantages in facilitating discharge to home, suggesting that tailored ward environments may better support AD patients. These findings underscore the importance of therapeutic environments in dementia care and highlight the need for further research on specialized dementia ward designs to improve outcomes and patient satisfaction. <a href="/2075-4426/15/3/82">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jpm/sections/clinical_medicine_cell_organism_physiology">Clinical Medicine, Cell, and Organism Physiology</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 13 pages, 11218 KiB   </span> <a href="/2075-4426/15/3/81/pdf?version=1740474752" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Minimally Invasive Lapidus Arthrodesis Associated with Distal Osteotomy of M1: A Combined Procedure for Hallux Valgus Correction" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2075-4426/15/3/81">Minimally Invasive Lapidus Arthrodesis Associated with Distal Osteotomy of M1: A Combined Procedure for Hallux Valgus Correction</a> <div class="authors"> by <span class="inlineblock "><strong>Fabrizio De Marchi</strong>, </span><span class="inlineblock "><strong>Ilaria Alice Crippa</strong>, </span><span class="inlineblock "><strong>Andrea Bobba</strong>, </span><span class="inlineblock "><strong>Alessandro Pudda</strong>, </span><span class="inlineblock "><strong>Filippo Maria Anghilieri</strong>, </span><span class="inlineblock "><strong>Francesco Verde</strong>, </span><span class="inlineblock "><strong>Filippo Familiari</strong> and </span><span class="inlineblock "><strong>Lorenzo Monti</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(3), 81; https://doi.org/10.3390/jpm15030081 (registering DOI) - 25 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background</b>: Hallux valgus is a common painful condition with tri-planar deformity of the first ray. Surgical correction consists of distal osteotomy of the first metatarsal and its lateral translation. However, in the case of hypermobility of the first cuneo-metatarsal joint (TMTJ), the <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/3/81/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background</b>: Hallux valgus is a common painful condition with tri-planar deformity of the first ray. Surgical correction consists of distal osteotomy of the first metatarsal and its lateral translation. However, in the case of hypermobility of the first cuneo-metatarsal joint (TMTJ), the associated Lapidus procedure is indicated to correct deformities along all three anatomical planes. Lapidus procedure is reported to have several contraindications and complications; for this reason, many surgeons proposed technical modification to the original procedure. We present the results of a novel surgical technique for hallux valgus correction with minimally invasive arthrodesis of first TMTJ without proximal correction of deformity, combined with a distal Austin-Chevron procedure. Materials and <b>Methods</b>: We retrospectively evaluated patients who underwent surgical correction of hallux valgus with our technique between January 2010 and January 2020. We collected data on demographics, anesthesiologic technique, associated surgical procedures, post-operative functional results, and complications. Dorso-plantar and lateral radiographs were performed at 6, 12, and 24 weeks after surgery or until fusion was documented. Clinical assessment considered gait analysis, pain or other disturbance, type of shoes worn, and use of orthosis. <b>Results</b>: A total of 240 patients were enrolled. AOFAS score, hallux valgus angle, and inter-metatarsal angle showed a significant improvement. Complications consisted of distal osteotomy non-union (1%), pain or protrusion of the screw (13%), and recurrence of deformity (2%). Overall, patients were very satisfied with the surgery in 192/278 (69%) cases, moderately satisfied in 67/278 (24%) cases, satisfied in 8/278 (3%) cases, and dissatisfied in 11/278 (4%) cases. <b>Conclusions</b>: Our novel surgical technique which combines in situ arthrodesis of the first tarso-metatarsal joint (TMTJ) with a distal Austin-Chevron procedure offers an effective alternative for correcting hallux valgus with first-ray hypermobility, minimizing complications associated with traditional methods. <a href="/2075-4426/15/3/81">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jpm/special_issues/G0676Y85YM ">Novel Challenges and Advances in Orthopaedic and Trauma Surgery</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2075-4426/15/3/81/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1599050"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1599050"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1599050" data-cycle-prev="#prev1599050" data-cycle-progressive="#images1599050" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1599050-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g001-550.jpg?1740474863" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1599050" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1599050-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g002-550.jpg?1740474865'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1599050-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g003-550.jpg?1740474867'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1599050-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g004-550.jpg?1740474869'><p>Figure 4</p></div> --- <div class='openpopupgallery' data-imgindex='4' data-target='article-1599050-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g005-550.jpg?1740474871'><p>Figure 5</p></div> --- <div class='openpopupgallery' data-imgindex='5' data-target='article-1599050-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g006-550.jpg?1740474872'><p>Figure 6</p></div> --- <div class='openpopupgallery' data-imgindex='6' data-target='article-1599050-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g007-550.jpg?1740474874'><p>Figure 7</p></div> --- <div class='openpopupgallery' data-imgindex='7' data-target='article-1599050-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g008-550.jpg?1740474876'><p>Figure 8</p></div> --- <div class='openpopupgallery' data-imgindex='8' data-target='article-1599050-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g009-550.jpg?1740474878'><p>Figure 9</p></div> --- <div class='openpopupgallery' data-imgindex='9' data-target='article-1599050-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g010-550.jpg?1740474880'><p>Figure 10</p></div> --- <div class='openpopupgallery' data-imgindex='10' data-target='article-1599050-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g011-550.jpg?1740474881'><p>Figure 11</p></div></script></div></div><div id="article-1599050-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g001-550.jpg?1740474863" title=" <strong>Figure 1</strong><br/> <p>Approach to the 1st TMTJ with 3 cm skin incision.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/81'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g002-550.jpg?1740474865" title=" <strong>Figure 2</strong><br/> <p>Removal of articular cartilage through sawing.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/81'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g003-550.jpg?1740474867" title=" <strong>Figure 3</strong><br/> <p>Removal of articular cartilage through sawing.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/81'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g004-550.jpg?1740474869" title=" <strong>Figure 4</strong><br/> <p>Fusion of the 1st TMTJ and temporary fixation through k-wires.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/81'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g005-550.jpg?1740474871" title=" <strong>Figure 5</strong><br/> <p>Fusion of the 1st TMTJ and temporary fixation through k-wires.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/81'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g006-550.jpg?1740474872" title=" <strong>Figure 6</strong><br/> <p>Intraoperative fluoroscopic check of wires positioning for 1st TMTJ fusion.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/81'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g007-550.jpg?1740474874" title=" <strong>Figure 7</strong><br/> <p>Intraoperative fluoroscopic check of wires positioning for 1st TMTJ fusion.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/81'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g008-550.jpg?1740474876" title=" <strong>Figure 8</strong><br/> <p>Screws positioning for 1st TMTJ fusion.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/81'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g009-550.jpg?1740474878" title=" <strong>Figure 9</strong><br/> <p>Intraoperative fluoroscopic check of screws positioning.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/81'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g010-550.jpg?1740474880" title=" <strong>Figure 10</strong><br/> <p>Post-operative weight-bearing X-rays of the foot: lateral view (<b>left</b>) and dorsoplantar view (<b>right</b>).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/81'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00081/article_deploy/html/images/jpm-15-00081-g011-550.jpg?1740474881" title=" <strong>Figure 11</strong><br/> <p>Three-month post-operative weight-bearing X-rays of the foot: dorsoplantar view (<b>left</b>) and lateral view (<b>right</b>).</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/81'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1598705" aria-controls="drop-supplementary-1598705" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1598705" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2075-4426/15/3/80/s1?version=1740411076"> Supplementary File 1 (ZIP, 324 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 13 pages, 651 KiB   </span> <a href="/2075-4426/15/3/80/pdf?version=1740473254" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="The Public Knowledge of Precision Medicine and Genomic Research: A Survey in the Aosta Valley" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2075-4426/15/3/80">The Public Knowledge of Precision Medicine and Genomic Research: A Survey in the Aosta Valley</a> <div class="authors"> by <span class="inlineblock "><strong>Matteo Mongelli</strong>, </span><span class="inlineblock "><strong>Biagio De Angelis</strong>, </span><span class="inlineblock "><strong>Valeria delle Cave</strong>, </span><span class="inlineblock "><strong>Giuliano Greco</strong>, </span><span class="inlineblock "><strong>Arianna De Arcangelis</strong>, </span><span class="inlineblock "><strong>Andrea Bernagozzi</strong>, </span><span class="inlineblock "><strong>Chiara Salvemini</strong>, </span><span class="inlineblock "><strong>Matteo Calabrese</strong>, </span><span class="inlineblock "><strong>Jean Marc Christille</strong>, </span><span class="inlineblock "><strong>Andrea Cavalli</strong>, </span><span class="inlineblock "><strong>Stefano Gustincich</strong> and </span><span class="inlineblock "><strong>Maria Grazia Monaci</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(3), 80; https://doi.org/10.3390/jpm15030080 (registering DOI) - 24 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background</b>: Precision medicine (PM) considers the genetic variability of individuals to identify tailored diagnosis and treatments. It relies on the possibility of gathering the widest possible health data and genetic information from individuals to obtain a broad pool of comparative data. To <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/3/80/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background</b>: Precision medicine (PM) considers the genetic variability of individuals to identify tailored diagnosis and treatments. It relies on the possibility of gathering the widest possible health data and genetic information from individuals to obtain a broad pool of comparative data. To achieve this goal, the Region of Valle d’Aosta, since 2019, has co-financed the research center CMP<sup>3</sup>VdA, aiming to sequence 5000 genomes of patients with neurodevelopmental, neurodegenerative, oncological, and organ transplantation diseases, and to investigate the genetic variability of the resident population. <b>Methods:</b> This paper presents the results of an online survey of 472 (328F) respondents regarding willingness to participate in the genomic project and awareness, attitudes, and concerns about PM. <b>Results</b>: The main results show that the vast majority (92.6%) would be willing to participate—a higher percentage than in previous studies. Age, education, and prior experience in the healthcare sector are significant factors influencing the awareness of PM. Additionally, subgroups organized by age, gender, and religiosity show significant differences with respect to participants’ reasons for participating in research and which types of biological samples they would be willing to donate. <b>Conclusions</b>: Our findings can serve as a guide for stakeholders—particularly policymakers—to target institutional communication and achieve maximum participation in genomic research projects. <a href="/2075-4426/15/3/80">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jpm/sections/omics">Omics/Informatics</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2075-4426/15/3/80/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1598705"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1598705"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1598705" data-cycle-prev="#prev1598705" data-cycle-progressive="#images1598705" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1598705-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jpm/jpm-15-00080/article_deploy/html/images/jpm-15-00080-g001-550.jpg?1740473376" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1598705" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1598705-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00080/article_deploy/html/images/jpm-15-00080-g002-550.jpg?1740473378'><p>Figure 2</p></div></script></div></div><div id="article-1598705-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jpm/jpm-15-00080/article_deploy/html/images/jpm-15-00080-g001-550.jpg?1740473376" title=" <strong>Figure 1</strong><br/> <p>Results that respondents would like to receive.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/80'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00080/article_deploy/html/images/jpm-15-00080-g002-550.jpg?1740473378" title=" <strong>Figure 2</strong><br/> <p>Minimum likelihood of developing a disease for which the respondent would like to be notified.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/80'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 14 pages, 888 KiB   </span> <a href="/2075-4426/15/3/79/pdf?version=1740119400" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Obeticholic Acid Improves Cholestasis, Liver Fibrosis, and Liver Function in Patients with Primary Biliary Cholangitis with Inadequate Response to Ursodeoxycholic Acid" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2075-4426/15/3/79">Obeticholic Acid Improves Cholestasis, Liver Fibrosis, and Liver Function in Patients with Primary Biliary Cholangitis with Inadequate Response to Ursodeoxycholic Acid</a> <div class="authors"> by <span class="inlineblock "><strong>Matthias Buechter</strong>, </span><span class="inlineblock "><strong>Paul Manka</strong>, </span><span class="inlineblock "><strong>Kerem Bulut</strong>, </span><span class="inlineblock "><strong>Guido Gerken</strong> and </span><span class="inlineblock "><strong>Alisan Kahraman</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(3), 79; <a href="https://doi.org/10.3390/jpm15030079">https://doi.org/10.3390/jpm15030079</a> - 21 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background and Aims:</b> Primary biliary cholangitis (PBC) leads to the slow, progressive destruction of the small bile ducts with consecutive cholestasis and intrahepatic cholangitis. If this disease remains untreated, liver parenchyma will be damaged resulting in fibrosis and end-stage liver disease with the <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/3/79/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background and Aims:</b> Primary biliary cholangitis (PBC) leads to the slow, progressive destruction of the small bile ducts with consecutive cholestasis and intrahepatic cholangitis. If this disease remains untreated, liver parenchyma will be damaged resulting in fibrosis and end-stage liver disease with the need for transplantation. The approval of the Farnesoid X receptor agonist obeticholic acid (Ocaliva; OCA) in early 2017 expanded the drug therapy options of PBC, which previously consisted primarily of the administration of ursodeoxycholic acid (UDCA). <b>Patients and Methods:</b> Included in our prospective pilot study were 16 patients with a confirmed diagnosis of PBC who were treated with an add-on therapy with OCA (5 mg/d). None of the patients had an overlap to autoimmune hepatitis. Patients were investigated between 09/2022 and 09/2023. <b>Results:</b> The majority of patients was female (15/16, 93.75%), and the mean age was 57.63 ± 9.59 (43–77) years. OCA treatment led to a statistically significant decrease in aspartate aminotransferase (AST; AST baseline: 38.50 [26.25; 50.00] IU/L vs. AST 6-month follow-up: 23.50 [21.50; 44.25] IU/L, <i>p</i> = 0.0012), alanine aminotransferase (ALT; ALT baseline: 55.50 [28.75; 97.00] IU/L vs. ALT 6-month follow-up: 36.50 [28.00; 57.25] IU/L, <i>p</i> = 0.0035), and gamma-glutamyl transferase (GGT; GGT baseline: 168.00 [100.30; 328.50] IU/L vs. GGT 6-month follow-up: 88.00 [44.50; 259.80] IU/L, <i>p</i> = 0.0063), while the decrease in alkaline phosphatase (AP) was not statistically significant (AP baseline: 197.00 [170.00; 253.30] IU/L vs. AP 6-month follow-up: 196.00 [134.00; 227.00] IU/L, <i>p</i> = 0.0915). In addition, liver stiffness measurement (LSM) showed a statistically significant decrease after six months of treatment with OCA (LSM baseline: 7.85 [5.55; 10.13] kPa vs. LSM 6-month follow-up: 5.95 [4.55; 8.225] kPa, <i>p</i> = 0.0001). However, the increase in enzymatic liver function measured by LiMAx failed to reach statistical significance, but showed a positive trend (LiMAx baseline: 402.50 [341.50; 469.80] μg/kg/h vs. LiMAx 6-month follow-up: 452.50 [412.50; 562.00] μg/kg/h, <i>p</i> = 0.0625). In none of our patients did therapy with obeticholic acid have to be stopped due to pruritus or poor tolerability. <b>Conclusions:</b> In patients with PBC without adequate response to UDCA, OCA is a promising alternative, which in our group of 16 patients led to a significant improvement of liver enzymes, the amelioration of liver fibrosis, and an increase in liver function capacity in a short-term clinical course. <a href="/2075-4426/15/3/79">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jpm/sections/personalized_therapy_drug_delivery">Personalized Therapy and Drug Delivery</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2075-4426/15/3/79/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1596213"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1596213"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1596213" data-cycle-prev="#prev1596213" data-cycle-progressive="#images1596213" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1596213-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jpm/jpm-15-00079/article_deploy/html/images/jpm-15-00079-g001-550.jpg?1740119472" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1596213" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1596213-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00079/article_deploy/html/images/jpm-15-00079-g002-550.jpg?1740119476'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1596213-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00079/article_deploy/html/images/jpm-15-00079-g003-550.jpg?1740119479'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1596213-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00079/article_deploy/html/images/jpm-15-00079-g004-550.jpg?1740119483'><p>Figure 4</p></div> --- <div class='openpopupgallery' data-imgindex='4' data-target='article-1596213-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00079/article_deploy/html/images/jpm-15-00079-g005-550.jpg?1740119484'><p>Figure 5</p></div> --- <div class='openpopupgallery' data-imgindex='5' data-target='article-1596213-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00079/article_deploy/html/images/jpm-15-00079-g006-550.jpg?1740119485'><p>Figure 6</p></div></script></div></div><div id="article-1596213-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jpm/jpm-15-00079/article_deploy/html/images/jpm-15-00079-g001-550.jpg?1740119472" title=" <strong>Figure 1</strong><br/> <p>Course of individual aspartate aminotransferase (AST) values during OCA treatment (<span class="html-italic">p</span> = 0.0012). ** <span class="html-italic">p</span> &lt; 0.01.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/79'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00079/article_deploy/html/images/jpm-15-00079-g002-550.jpg?1740119476" title=" <strong>Figure 2</strong><br/> <p>Course of individual alanine aminotransferase (ALT) values during OCA treatment (<span class="html-italic">p</span> = 0.0035). ** <span class="html-italic">p</span> &lt; 0.01.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/79'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00079/article_deploy/html/images/jpm-15-00079-g003-550.jpg?1740119479" title=" <strong>Figure 3</strong><br/> <p>Course of individual gamma-glutamyl transferase (GGT) values during OCA treatment (<span class="html-italic">p</span> = 0.0063). ** <span class="html-italic">p</span> &lt; 0.01.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/79'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00079/article_deploy/html/images/jpm-15-00079-g004-550.jpg?1740119483" title=" <strong>Figure 4</strong><br/> <p>Course of individual alkaline phosphatase (AP) values during OCA treatment (<span class="html-italic">p</span> = 0.0915). ns = not significant.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/79'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00079/article_deploy/html/images/jpm-15-00079-g005-550.jpg?1740119484" title=" <strong>Figure 5</strong><br/> <p>Course of individual liver stiffness measurement (LSM) values during OCA treatment (<span class="html-italic">p</span> = 0.0001). *** <span class="html-italic">p</span> &lt; 0.001.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/79'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00079/article_deploy/html/images/jpm-15-00079-g006-550.jpg?1740119485" title=" <strong>Figure 6</strong><br/> <p>Course of individual LiMAx values during OCA treatment (<span class="html-italic">p</span> = 0.0625). ns = not significant.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/79'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 13 pages, 238 KiB   </span> <a href="/2075-4426/15/3/78/pdf?version=1740069440" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Metabolic Syndrome Indicators and Cardiovascular/Endocrine Risks in Rural Ecuador: A Cross-Sectional Study" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2075-4426/15/3/78">Metabolic Syndrome Indicators and Cardiovascular/Endocrine Risks in Rural Ecuador: A Cross-Sectional Study</a> <div class="authors"> by <span class="inlineblock "><strong>Guillermo Fernando León-Samaniego</strong>, </span><span class="inlineblock "><strong>Holguer Estuardo Romero Urréa</strong>, </span><span class="inlineblock "><strong>Freddy Espinoza-Carrasco</strong>, </span><span class="inlineblock "><strong>Mariana de Jesús Llimaico Noriega</strong>, </span><span class="inlineblock "><strong>Grecia Elizabeth Encalada Campos</strong>, </span><span class="inlineblock "><strong>Pedro Herrera</strong>, </span><span class="inlineblock "><strong>Angela Chavez-Cembellin</strong> and </span><span class="inlineblock "><strong>Marco Faytong-Haro</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(3), 78; <a href="https://doi.org/10.3390/jpm15030078">https://doi.org/10.3390/jpm15030078</a> - 20 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives:</b> This study assessed the prevalence of metabolic syndrome (MetS) and its association with cardiovascular and endocrine diseases in a rural Ecuadorian parish population. <b>Methods:</b> This cross-sectional study included 200 participants. Descriptive statistics were computed for glucose, total cholesterol, and triglyceride levels. Logistic <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/3/78/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives:</b> This study assessed the prevalence of metabolic syndrome (MetS) and its association with cardiovascular and endocrine diseases in a rural Ecuadorian parish population. <b>Methods:</b> This cross-sectional study included 200 participants. Descriptive statistics were computed for glucose, total cholesterol, and triglyceride levels. Logistic regression estimated the odds ratios (ORs) for the likelihood of cardiovascular (hypertension, coronary artery disease, stroke) and endocrine diseases (diabetes and other metabolic disorders) in relation to MetS biomarkers. <b>Results:</b> The study included 200 participants, with average glucose (123.09 mg/dL), cholesterol (229.58 mg/dL), and triglycerides (188.75 mg/dL) levels exceeding standard thresholds. Logistic regression analysis showed that glucose was the strongest predictor, increasing cardiovascular disease odds by 6.9% (OR = 1.069, <i>p</i> < 0.001) and endocrine disease odds by 11.8% (OR = 1.118, <i>p</i> < 0.001) after adjustment. Cholesterol and triglycerides also significantly contributed to the risk of both diseases. The models demonstrated a high predictive performance (AUC: 0.933 for cardiovascular disease and 0.993 for endocrine diseases). <b>Conclusions:</b> MetS was significantly associated with cardiovascular and endocrine disease risks in the rural population. Integrating personalized healthcare, such as tailored dietary counseling, culturally adapted interventions, and mobile health technologies, is crucial for improving the early detection and management of MetS in underserved communities. <a href="/2075-4426/15/3/78">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jpm/sections/epidemiology">Epidemiology</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 17 pages, 363 KiB   </span> <a href="/2075-4426/15/3/77/pdf?version=1740381403" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Trachelectomy and Cerclage Placement as Fertility-Sparing Surgery for Cervical Cancer—An Expert Survey" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2075-4426/15/3/77">Trachelectomy and Cerclage Placement as Fertility-Sparing Surgery for Cervical Cancer—An Expert Survey</a> <div class="authors"> by <span class="inlineblock "><strong>Anke Smits</strong>, </span><span class="inlineblock "><strong>Janneke T. Wolswinkel</strong>, </span><span class="inlineblock "><strong>Mieke L. G. ten Eikelder</strong>, </span><span class="inlineblock "><strong>Nadeem R. Abu-Rustum</strong>, </span><span class="inlineblock "><strong>Glauco Baiocchi</strong>, </span><span class="inlineblock "><strong>Jogchum J. Beltman</strong>, </span><span class="inlineblock "><strong>Allan Covens</strong>, </span><span class="inlineblock "><strong>Karlijn M. C. Cornel</strong>, </span><span class="inlineblock "><strong>Henrik Falconer</strong>, </span><span class="inlineblock "><strong>Christina Fotopoulou</strong>, </span><span class="inlineblock "><strong>Cornelis G. Gerestein</strong>, </span><span class="inlineblock "><strong>Blanca Gil-Ibanez</strong>, </span><span class="inlineblock "><strong>Peter Hillemanns</strong>, </span><span class="inlineblock "><strong>Christhardt Köhler</strong>, </span><span class="inlineblock "><strong>Ali Kucukmetin</strong>, </span><span class="inlineblock "><strong>Luc R. C. W. van Lonkhuijzen</strong>, </span><span class="inlineblock "><strong>Philippe Morice</strong>, </span><span class="inlineblock "><strong>Joo Hyun Nam</strong>, </span><span class="inlineblock "><strong>Myriam B. Perrotta</strong>, </span><span class="inlineblock "><strong>Jan Persson</strong>, </span><span class="inlineblock author-item-hidden js-author-item-hidden"><strong>Marie Plante</strong>, </span><span class="inlineblock author-item-hidden js-author-item-hidden"><strong>Denis Querleu</strong>, </span><span class="inlineblock author-item-hidden js-author-item-hidden"><strong>Reitan Ribeiro</strong>, </span><span class="inlineblock author-item-hidden js-author-item-hidden"><strong>Laszlo Ungár</strong>, </span><span class="inlineblock author-item-hidden js-author-item-hidden"><strong>Maaike A. P. C. van Ham</strong> and </span><span class="inlineblock author-item-hidden js-author-item-hidden"><strong>Petra L. M. Zusterzeel</strong></span><a href="#" class="show-full-author-list"><i class="material-icons">add</i> Show full author list </a><a href="#" class="hide-full-author-list"><i class="material-icons">remove</i> Hide full author list </a> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(3), 77; https://doi.org/10.3390/jpm15030077 (registering DOI) - 20 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives</b>: Fertility-sparing surgery (FSS) is a standard practice for managing early stage cervical cancer, yet significant variation exists in clinical approaches worldwide. Our objective was to ascertain current practices and preferences for cerclage use among expert centers globally regarding FSS in patients <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/3/77/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives</b>: Fertility-sparing surgery (FSS) is a standard practice for managing early stage cervical cancer, yet significant variation exists in clinical approaches worldwide. Our objective was to ascertain current practices and preferences for cerclage use among expert centers globally regarding FSS in patients with early stage cervical cancer. <b>Methods</b>: We conducted a cross-sectional survey from May to July 2023 involving expert centers identified through their scientific contributions and participation in international workgroups and conferences.. The survey, comprising 27 questions, evaluated existing practices in FSS. <b>Results</b>: Out of the centers surveyed, 21 (36.2%) gynecologic oncologists responded. For tumors <2 cm, 86% of centers preferred radical trachelectomy, primarily via the vaginal approach, while 13.6% favored a simple trachelectomy. Three experts preferred simple trachelectomy (13.6%). For tumors >2 cm, 47.6% utilized neoadjuvant chemotherapy before trachelectomy. Others did not offer FSS or performed an abdominal radical trachelectomy. Over time, there has been a shift towards less radical surgeries for tumors <2 cm and increased use of neoadjuvant chemotherapy for larger tumors. Some abandoned the minimally invasive surgical approach. Nearly all experts (90.5%) placed a cerclage immediately following trachelectomy. <b>Conclusions</b>: The majority of experts opt for radical trachelectomy in early stage cervical cancer, with immediate cerclage placement being a common practice. However, considerable international variations highlight the urgent need for standardized guidelines and further research to optimize treatment strategies, balancing oncological safety with fertility outcomes. <a href="/2075-4426/15/3/77">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jpm/special_issues/5IJIESO3FA ">Gynecological Oncology: Personalized Diagnosis and Therapy</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2075-4426/15/3/77/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="absgraph cycle-slideshow"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1595218-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jpm/jpm-15-00077/article_deploy/html/images/jpm-15-00077-g001-550.jpg?1740381487" alt="" style="border: 0;"><p>Figure 1</p></div></div></div><div id="article-1595218-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jpm/jpm-15-00077/article_deploy/html/images/jpm-15-00077-g001-550.jpg?1740381487" title=" <strong>Figure 1</strong><br/> <p>Location of cerclage placement.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/3/77'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1594930" aria-controls="drop-supplementary-1594930" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1594930" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2075-4426/15/2/76/s1?version=1739974406"> Supplementary File 1 (ZIP, 33438 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 28 pages, 5098 KiB   </span> <a href="/2075-4426/15/2/76/pdf?version=1740028807" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="A Methodological Framework for AI-Assisted Diagnosis of Ovarian Masses Using CT and MR Imaging" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2075-4426/15/2/76">A Methodological Framework for AI-Assisted Diagnosis of Ovarian Masses Using CT and MR Imaging</a> <div class="authors"> by <span class="inlineblock "><strong>Pratik Adusumilli</strong>, </span><span class="inlineblock "><strong>Nishant Ravikumar</strong>, </span><span class="inlineblock "><strong>Geoff Hall</strong> and </span><span class="inlineblock "><strong>Andrew F. Scarsbrook</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(2), 76; <a href="https://doi.org/10.3390/jpm15020076">https://doi.org/10.3390/jpm15020076</a> - 19 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Ovarian cancer encompasses a diverse range of neoplasms originating in the ovaries, fallopian tubes, and peritoneum. Despite being one of the commonest gynaecological malignancies, there are no validated screening strategies for early detection. A diagnosis typically relies on imaging, biomarkers, and multidisciplinary <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/76/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Ovarian cancer encompasses a diverse range of neoplasms originating in the ovaries, fallopian tubes, and peritoneum. Despite being one of the commonest gynaecological malignancies, there are no validated screening strategies for early detection. A diagnosis typically relies on imaging, biomarkers, and multidisciplinary team discussions. The accurate interpretation of CTs and MRIs may be challenging, especially in borderline cases. This study proposes a methodological pipeline to develop and evaluate deep learning (DL) models that can assist in classifying ovarian masses from CT and MRI data, potentially improving diagnostic confidence and patient outcomes. <b>Methods:</b> A multi-institutional retrospective dataset was compiled, supplemented by external data from the Cancer Genome Atlas. Two classification workflows were examined: (1) whole-volume input and (2) lesion-focused region of interest. Multiple DL architectures, including ResNet, DenseNet, transformer-based UNeST, and Attention Multiple-Instance Learning (MIL), were implemented within the PyTorch-based MONAI framework. The class imbalance was mitigated using focal loss, oversampling, and dynamic class weighting. The hyperparameters were optimised with Optuna, and balanced accuracy was the primary metric. <b>Results:</b> For a preliminary dataset, the proposed framework demonstrated feasibility for the multi-class classification of ovarian masses. The initial experiments highlighted the potential of transformers and MIL for identifying the relevant imaging features. <b>Conclusions:</b> A reproducible methodological pipeline for DL-based ovarian mass classification using CT and MRI scans has been established. Future work will leverage a multi-institutional dataset to refine these models, aiming to enhance clinical workflows and improve patient outcomes. <a href="/2075-4426/15/2/76">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jpm/special_issues/K0MKOWMF51 ">Artificial Intelligence Applications in Precision Oncology</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/76/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1594930"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1594930"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1594930" data-cycle-prev="#prev1594930" data-cycle-progressive="#images1594930" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1594930-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-ag-550.jpg?1740046203" alt="" style="border: 0;"><p>Graphical abstract</p></div><script id="images1594930" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1594930-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g001-550.jpg?1740046177'><p>Figure 1</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1594930-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g002-550.jpg?1740046178'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1594930-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g003-550.jpg?1740046182'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='4' data-target='article-1594930-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g004-550.jpg?1740046184'><p>Figure 4</p></div> --- <div class='openpopupgallery' data-imgindex='5' data-target='article-1594930-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g005-550.jpg?1740046185'><p>Figure 5</p></div> --- <div class='openpopupgallery' data-imgindex='6' data-target='article-1594930-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g006-550.jpg?1740046187'><p>Figure 6</p></div> --- <div class='openpopupgallery' data-imgindex='7' data-target='article-1594930-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g007-550.jpg?1740046189'><p>Figure 7</p></div> --- <div class='openpopupgallery' data-imgindex='8' data-target='article-1594930-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g008-550.jpg?1740046189'><p>Figure 8</p></div> --- <div class='openpopupgallery' data-imgindex='9' data-target='article-1594930-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g009-550.jpg?1740046193'><p>Figure 9</p></div></script></div></div><div id="article-1594930-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-ag-550.jpg?1740046203" title=" <strong>Graphical abstract</strong><br/><strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/76'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g001-550.jpg?1740046177" title=" <strong>Figure 1</strong><br/> <p>Patient selection flow diagram.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/76'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g002-550.jpg?1740046178" title=" <strong>Figure 2</strong><br/> <p>Model development process.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/76'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g003-550.jpg?1740046182" title=" <strong>Figure 3</strong><br/> <p>Matplotlib visualisation of input data.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/76'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g004-550.jpg?1740046184" title=" <strong>Figure 4</strong><br/> <p>TensorBoard visualisation of the model training process, illustrating real-time monitoring of metrics and performance.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/76'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g005-550.jpg?1740046185" title=" <strong>Figure 5</strong><br/> <p>Schematic of the 3D ResNet architecture. The pipeline begins with a Conv 7 × 7 and a 3D MaxPool operation to reduce the spatial resolution, followed by multiple ResBlocks (each comprising 1 × 1 and 3 × 3 × 3 convolutions, batch normalisation, ReLU activations, and skip connections). A global AvgPool layer then condenses the volumetric features into a single vector, which is passed to an FC layer for final classification. The inset illustrates the typical ResBlock layout with Conv–BN–ReLU sequences, skip connections, and a final post-addition ReLU. Conv: convolution; BN: batch normalisation; ReLU: Rectified Linear Unit; AvgPool: global average pooling; FC: fully connected.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/76'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g006-550.jpg?1740046187" title=" <strong>Figure 6</strong><br/> <p>Schematic of 3D DenseNet architecture. The pipeline begins with a Conv 7 × 7 for initial feature extraction, followed by a 3D MaxPool to reduce spatial resolution. A series of dense blocks (purple) and transition blocks (orange) then iteratively expand and reduce the feature dimensions. Each dense block comprises successive Conv–BN–ReLU operations, concatenating outputs from all preceding layers, while each transition block (Conv 1 × 1 + AvgPool) reduces feature map size and channels. A global AvgPool layer aggregates the final volumetric features into a single vector, which is passed to a fully connected (FC) layer for classification. The insets illustrate the typical internal layout of a dense block and transition block.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/76'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g007-550.jpg?1740046189" title=" <strong>Figure 7</strong><br/> <p>Schematic of 3D UNesT architecture. The 3D input volume is passed through a 3-level NesT to produce multi-scale feature maps {x1,x2,x3,x4}{x1,x2,x3,x4}, as well as a final feature map, xx. Each intermediate NesT output is fed into a corresponding encoder block (encoder1–encoder4encoder1–encoder4), comprising 3D convolutions (with BN/ReLU) and/or upsampling, yielding encoded features enc0–enc3enc0–enc3. The final NesT output, xx, is further processed by an additional encoder (e.g., encoder10) to expand feature depth. In the decoder phase, skip connections fuse the encoder outputs with transposed convolution layers (decoder5–decoder1) to reconstruct intermediate 3D representations. A classification head (global average pooling followed by a dense layer and softmax) aggregates the final 3D representation to produce class probabilities. NesT: nested transformer; BN: batch normalisation; dec: decoder; enc: encoder; ReLU: Rectified Linear Unit; AvgPool: global average pooling.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/76'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g008-550.jpg?1740046189" title=" <strong>Figure 8</strong><br/> <p>Schematic of the 3D attention-based Multiple-Instance Learning (MIL) pipeline. The pipeline starts with a 3D input volume (CT or MRI) split into multiple patches (forming a “bag”). Each patch is processed by a 3D ResNet3D ResNet-50 (Residual Network) to extract the patch-level feature embedding, which is then flattened spatially. These embeddings are passed through an attention block comprising an MLP (Multi-Layer Perceptron) and a softmax over NN patches to yield the attention weights. The weighted sum of the patch embeddings is computed according to these attention weights, producing a single aggregated feature vector. Finally, this aggregated representation is fed into an FC (fully connected) layer for the final classification. 3D: three-Dimensional; ResNet: Residual Network; MLP: Multi-Layer Perceptron; FC: fully connected.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/76'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00076/article_deploy/html/images/jpm-15-00076-g009-550.jpg?1740046193" title=" <strong>Figure 9</strong><br/> <p>Grad-Cam visualisation: the upper image demonstrates a “hot” (red) malignant lesion and the lower image demonstrates “hot” (red) regions of omental disease.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/76'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 17 pages, 1065 KiB   </span> <a href="/2075-4426/15/2/75/pdf?version=1739956024" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Multimodality Imaging in the Diagnosis of Coronary Microvascular Disease: An Update" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Review</span></div> <a class="title-link" href="/2075-4426/15/2/75">Multimodality Imaging in the Diagnosis of Coronary Microvascular Disease: An Update</a> <div class="authors"> by <span class="inlineblock "><strong>Ana Margarida Martins</strong>, </span><span class="inlineblock "><strong>Miguel Nobre Menezes</strong>, </span><span class="inlineblock "><strong>Pedro Alves da Silva</strong> and </span><span class="inlineblock "><strong>Ana G. Almeida</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(2), 75; <a href="https://doi.org/10.3390/jpm15020075">https://doi.org/10.3390/jpm15020075</a> - 19 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> Coronary microvascular dysfunction (CMD) is characterized by structural and functional abnormalities in the coronary microvasculature which can lead to ischaemia and angina and is increasingly recognized as a major contributor to adverse cardiovascular outcomes. Despite its clinical importance, the diagnosis of CMD remains <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/75/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> Coronary microvascular dysfunction (CMD) is characterized by structural and functional abnormalities in the coronary microvasculature which can lead to ischaemia and angina and is increasingly recognized as a major contributor to adverse cardiovascular outcomes. Despite its clinical importance, the diagnosis of CMD remains limited compared with traditional atherosclerotic coronary artery disease. Furthermore, the historical lack of non-invasive methods for detecting and quantifying CMD has hindered progress in understanding its pathophysiology and clinical implications. This review explores advancements in non-invasive cardiac imaging that have enabled the detection and quantification of CMD. It evaluates the clinical utility, strengths and limitation of these imaging modalities in diagnosing and managing CMD. Having improved our understanding of CMD pathophysiology, cardiac imaging can provide insights into its prognosis and enhance diagnostic accuracy. Continued innovation in imaging technologies is essential for advancing knowledge about CMD, leading to improved cardiovascular outcomes and patient care. <a href="/2075-4426/15/2/75">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jpm/sections/clinical_medicine_cell_organism_physiology">Clinical Medicine, Cell, and Organism Physiology</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/75/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1594480"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1594480"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1594480" data-cycle-prev="#prev1594480" data-cycle-progressive="#images1594480" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1594480-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jpm/jpm-15-00075/article_deploy/html/images/jpm-15-00075-g001-550.jpg?1739956095" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1594480" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1594480-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00075/article_deploy/html/images/jpm-15-00075-g002-550.jpg?1739956096'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1594480-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00075/article_deploy/html/images/jpm-15-00075-g003-550.jpg?1739956098'><p>Figure 3</p></div></script></div></div><div id="article-1594480-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jpm/jpm-15-00075/article_deploy/html/images/jpm-15-00075-g001-550.jpg?1739956095" title=" <strong>Figure 1</strong><br/> <p>Diagram of Coronary Macro- and Micro-Arterial Systems: Anatomy and Function.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/75'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00075/article_deploy/html/images/jpm-15-00075-g002-550.jpg?1739956096" title=" <strong>Figure 2</strong><br/> <p>Echocardiography-Derived Coronary Flow Volume Reserve. Using transthoracic Doppler echocardiography with a pulsed-wave sample placed on the anterior descending artery, mean diastolic velocities are measured at rest and during stress to calculate coronary flow velocity reserve.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/75'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00075/article_deploy/html/images/jpm-15-00075-g003-550.jpg?1739956098" title=" <strong>Figure 3</strong><br/> <p>Stress CMR (Cardiovascular Magnetic Resonance) perfusion in a 57-year-old men with hypertension, a history of chest pain, and exertional syncope. The coronary CTA (computer tomography angiography) showed a small calcific plaque with less than 10% stenosis in the proximal left anterior descending artery. On stress first-pass perfusion there was no inducible myocardial perfusion defect. On perfusion mapping (quantitative perfusion) there is an almost circumferential myocardial perfusion defect, with a globally myocardial perfusion reserve (MPR = 1.1) suggestive of microvascular dysfunction. Image kindly provided by the CMR services of Royal Brompton and Harefield Hospitals.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/75'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 1 pages, 138 KiB   </span> <a href="/2075-4426/15/2/74/pdf?version=1739932621" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Correction: Choi et al. Prognostic Value of Radiomic Analysis Using Pre- and Post-Treatment 18F-FDG-PET/CT in Patients with Laryngeal Cancer and Hypopharyngeal Cancer. J. Pers. Med. 2024, 14, 71" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Correction</span></div> <a class="title-link" href="/2075-4426/15/2/74">Correction: Choi et al. Prognostic Value of Radiomic Analysis Using Pre- and Post-Treatment <sup>18</sup>F-FDG-PET/CT in Patients with Laryngeal Cancer and Hypopharyngeal Cancer. <i>J. Pers. Med.</i> 2024, <i>14</i>, 71</a> <div class="authors"> by <span class="inlineblock "><strong>Joon Ho Choi</strong>, </span><span class="inlineblock "><strong>Joon Young Choi</strong>, </span><span class="inlineblock "><strong>Sang-Keun Woo</strong>, </span><span class="inlineblock "><strong>Ji Eun Moon</strong>, </span><span class="inlineblock "><strong>Chae Hong Lim</strong>, </span><span class="inlineblock "><strong>Soo Bin Park</strong>, </span><span class="inlineblock "><strong>Seongho Seo</strong>, </span><span class="inlineblock "><strong>Yong Chan Ahn</strong>, </span><span class="inlineblock "><strong>Myung-Ju Ahn</strong>, </span><span class="inlineblock "><strong>Seung Hwan Moon</strong> and </span><span class="inlineblock "><strong>Jung Mi Park</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(2), 74; <a href="https://doi.org/10.3390/jpm15020074">https://doi.org/10.3390/jpm15020074</a> - 19 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-full inline"> In the original publication [...] <a href="/2075-4426/15/2/74">Full article</a> </div> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 4 pages, 162 KiB   </span> <a href="/2075-4426/15/2/73/pdf?version=1739879055" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Pioneering Respiratory and Emergency Medicine Research During the COVID-19 Era" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Editorial</span></div> <a class="title-link" href="/2075-4426/15/2/73">Pioneering Respiratory and Emergency Medicine Research During the COVID-19 Era</a> <div class="authors"> by <span class="inlineblock "><strong>Ioannis Pantazopoulos</strong>, </span><span class="inlineblock "><strong>Georgios Mavrovounis</strong> and </span><span class="inlineblock "><strong>Konstantinos Gourgoulianis</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(2), 73; <a href="https://doi.org/10.3390/jpm15020073">https://doi.org/10.3390/jpm15020073</a> - 18 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-full inline"> Respiratory and emergency medicine have undergone significant transformations in recent years, shaped by advancements in critical care, the integration of artificial intelligence (AI), and the evolving understanding of post-infectious sequelae [...] <a href="/2075-4426/15/2/73">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jpm/special_issues/841FY634M9 ">Respiratory and Emergency Medicine</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 1 pages, 137 KiB   </span> <a href="/2075-4426/15/2/72/pdf?version=1739875601" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="RETRACTED: Yen et al. Brevilin A Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis and Reduces Th17 Differentiation in Psoriasis Patients. J. Pers. Med. 2022, 12, 1888" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Retraction</span></div> <a class="title-link" href="/2075-4426/15/2/72">RETRACTED: Yen et al. Brevilin A Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis and Reduces Th17 Differentiation in Psoriasis Patients. <i>J. Pers. Med.</i> 2022, <i>12</i>, 1888</a> <div class="authors"> by <span class="inlineblock "><strong>Ling-Jung Yen</strong>, </span><span class="inlineblock "><strong>Chung-Yang Yen</strong>, </span><span class="inlineblock "><strong>Chia-Ling Li</strong>, </span><span class="inlineblock "><strong>En-Chih Liao</strong>, </span><span class="inlineblock "><strong>Kai-Chun Wang</strong>, </span><span class="inlineblock "><strong>Meng-Chieh Shih</strong>, </span><span class="inlineblock "><strong>Hung-Sen Huang</strong>, </span><span class="inlineblock "><strong>Ying-Chin Chen</strong>, </span><span class="inlineblock "><strong>Ling-Ying Lu</strong> and </span><span class="inlineblock "><strong>Sheng-Jie Yu</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(2), 72; <a href="https://doi.org/10.3390/jpm15020072">https://doi.org/10.3390/jpm15020072</a> - 18 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-full inline"> The journal retracts the article “Brevilin A Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis and Reduces Th17 Differentiation in Psoriasis Patients” [...] <a href="/2075-4426/15/2/72">Full article</a> </div> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 12 pages, 2225 KiB   </span> <a href="/2075-4426/15/2/71/pdf?version=1739874619" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Real Index of Refraction of Normal and Cancerous Axillary Lymph Nodes in Breast Cancer Patients: Results from an Experimental Study" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2075-4426/15/2/71">Real Index of Refraction of Normal and Cancerous Axillary Lymph Nodes in Breast Cancer Patients: Results from an Experimental Study</a> <div class="authors"> by <span class="inlineblock "><strong>Maria Papadoliopoulou</strong>, </span><span class="inlineblock "><strong>Spyridon Koutsoumpos</strong>, </span><span class="inlineblock "><strong>Ioannis Margaris</strong>, </span><span class="inlineblock "><strong>Maria Matiatou</strong>, </span><span class="inlineblock "><strong>Panagiotis Giannios</strong>, </span><span class="inlineblock "><strong>Nikolaos Arkadopoulos</strong>, </span><span class="inlineblock "><strong>Konstantinos Moutzouris</strong> and </span><span class="inlineblock "><strong>Nikolaos V. Michalopoulos</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(2), 71; <a href="https://doi.org/10.3390/jpm15020071">https://doi.org/10.3390/jpm15020071</a> - 18 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Breast malignancy is the most common cancer type and the second leading cause of cancer-related death for women all ages. Axillary surgery provides prognostic and predictive information, but carries significant morbidity. Imaging techniques are a promising field, providing the characterization of biological <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/71/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Breast malignancy is the most common cancer type and the second leading cause of cancer-related death for women all ages. Axillary surgery provides prognostic and predictive information, but carries significant morbidity. Imaging techniques are a promising field, providing the characterization of biological tissues using the interaction between the light and a medium, and may offer an accurate cancerous diagnosis without the need for formal histopathological examination. <b>Methods:</b> In this study, using a prism couple refractometer, we sought to determine tissues’ reflection profiles in freshly excised human lymph nodes from female patients with breast cancer, in whom axillary lymph node dissection was performed. <b>Results:</b> Thirty-four patients were included, contributing a total number of 90 lymph nodes and, according to our results, the median refractive indices were significantly higher in cancerous lymph nodes compared to normal lymph nodes in 450 nm, 964 nm, and 1551 nm wavelengths (<i>p</i> < 0.05). <b>Conclusions:</b> Results from this small experimental study imply that the use of a prism couple refractometer may aid in the discrimination between benign and malignant axillary lymph nodes in female patients with breast cancer. <a href="/2075-4426/15/2/71">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jpm/special_issues/3109FY0Q37 ">Breast Cancer: Molecular Mechanisms, Diagnosis Techniques and Therapeutic Targets</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/71/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1593768"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1593768"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1593768" data-cycle-prev="#prev1593768" data-cycle-progressive="#images1593768" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1593768-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jpm/jpm-15-00071/article_deploy/html/images/jpm-15-00071-g001-550.jpg?1739874732" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1593768" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1593768-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00071/article_deploy/html/images/jpm-15-00071-g002-550.jpg?1739874733'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1593768-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00071/article_deploy/html/images/jpm-15-00071-g003-550.jpg?1739874733'><p>Figure 3</p></div> --- <div class='openpopupgallery' data-imgindex='3' data-target='article-1593768-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00071/article_deploy/html/images/jpm-15-00071-g004-550.jpg?1739874735'><p>Figure 4</p></div> --- <div class='openpopupgallery' data-imgindex='4' data-target='article-1593768-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00071/article_deploy/html/images/jpm-15-00071-g005-550.jpg?1739874736'><p>Figure 5</p></div></script></div></div><div id="article-1593768-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jpm/jpm-15-00071/article_deploy/html/images/jpm-15-00071-g001-550.jpg?1739874732" title=" <strong>Figure 1</strong><br/> <p>Tissue preparation. Retrieval included macroscopically positive as well as tumor-free lymph nodes from each patient. For experimental purposes and formal histopathological cross-examination, sampled lymph nodes were divided in half.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/71'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00071/article_deploy/html/images/jpm-15-00071-g002-550.jpg?1739874733" title=" <strong>Figure 2</strong><br/> <p>Experimental set-up. Prism coupling refractometer, inhere depicted at normal incidence with respect to the prism’s entrance facet. Five independent and interchangeable laser sources are used sequentially. A polarizer ensures the s-polarization of the input beam. A photodiode detects the reflected light from the prism/tissue interface. The prism and the detector stand on a computer-driven rotary table.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/71'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00071/article_deploy/html/images/jpm-15-00071-g003-550.jpg?1739874733" title=" <strong>Figure 3</strong><br/> <p>Wavelength scaling of the median refractive index values for the cancerous and non-cancerous tissue groups. Open circles are data shown in <a href="#jpm-15-00071-t002" class="html-table">Table 2</a>. Solid lines are corresponding Cauchi fits.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/71'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00071/article_deploy/html/images/jpm-15-00071-g004-550.jpg?1739874735" title=" <strong>Figure 4</strong><br/> <p>Wavelength scaling of the index contrast.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/71'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00071/article_deploy/html/images/jpm-15-00071-g005-550.jpg?1739874736" title=" <strong>Figure 5</strong><br/> <p>Wavelength scaling of GVD for cancerous and non-cancerous tissue types. Zero-crossing points in the near-infrared are observed.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/71'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 9 pages, 200 KiB   </span> <a href="/2075-4426/15/2/70/pdf?version=1739593649" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Serum Sortilin Levels as a Biomarker for Metabolic and Hormonal Dysregulation in Polycystic Ovary Syndrome" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2075-4426/15/2/70">Serum Sortilin Levels as a Biomarker for Metabolic and Hormonal Dysregulation in Polycystic Ovary Syndrome</a> <div class="authors"> by <span class="inlineblock "><strong>Pinar Alarslan</strong> and </span><span class="inlineblock "><strong>Mehmet Doruk</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(2), 70; <a href="https://doi.org/10.3390/jpm15020070">https://doi.org/10.3390/jpm15020070</a> - 15 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background/Objectives</b>: Polycystic ovarian syndrome (PCOS) is a complex endocrine disorder affecting up to 15% of reproductive-age women, characterized by hyperandrogenism, chronic oligo-ovulation, and metabolic dysfunction. This study aims to evaluate serum sortilin levels in women with PCOS for the first time and <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/70/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background/Objectives</b>: Polycystic ovarian syndrome (PCOS) is a complex endocrine disorder affecting up to 15% of reproductive-age women, characterized by hyperandrogenism, chronic oligo-ovulation, and metabolic dysfunction. This study aims to evaluate serum sortilin levels in women with PCOS for the first time and investigate their potential associations with metabolic and hormonal alterations. <b>Material and Methods:</b> Eighty PCOS patients and 80 healthy controls were included; serum sortilin levels were measured using ELISA kits, with documented intra-assay and inter-assay variations below 6% and 8%, respectively, ensuring high specificity and sensitivity. <b>Results:</b> Serum sortilin levels were significantly elevated in PCOS patients (69.51 ± 27.75 pg/mL) versus controls (48.60 ± 21.20 pg/mL) (<i>p</i> < 0.001). PCOS patients exhibited higher mean HOMA-IR, free androgen index values, serum glucose, insulin, triglycerides, high-sensitivity C-reactive protein, luteinizing hormone, total testosterone, and DHEA-S levels, alongside reduced high-density lipoprotein cholesterol and sex hormone-binding globulin levels (all, <i>p</i> < 0.05). Notably, inverse correlations were observed between sortilin and low-density lipoprotein cholesterol levels in both groups (<i>p</i> = 0.028 and 0.033). <b>Conclusions:</b> This pioneering study indicates that serum sortilin may be implicated in PCOS pathogenesis and serves as a potential biomarker for metabolic dysfunction in PCOS. Larger, diverse studies with longitudinal designs are needed for further validation. <a href="/2075-4426/15/2/70">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jpm/sections/disease_biomarker">Disease Biomarker</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 10 pages, 240 KiB   </span> <a href="/2075-4426/15/2/69/pdf?version=1739522473" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Attitudes of Neurologists Toward Serum Neurofilament Light-Chain Testing in the Management of Relapsing–Remitting Multiple Sclerosis with Cognitive Impairment" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Brief Report</span></div> <a class="title-link" href="/2075-4426/15/2/69">Attitudes of Neurologists Toward Serum Neurofilament Light-Chain Testing in the Management of Relapsing–Remitting Multiple Sclerosis with Cognitive Impairment</a> <div class="authors"> by <span class="inlineblock "><strong>José M. García-Domínguez</strong>, </span><span class="inlineblock "><strong>Jorge Maurino</strong>, </span><span class="inlineblock "><strong>José E. Meca-Lallana</strong>, </span><span class="inlineblock "><strong>Lamberto Landete</strong>, </span><span class="inlineblock "><strong>Virginia Meca-Lallana</strong>, </span><span class="inlineblock "><strong>Elena García-Arcelay</strong>, </span><span class="inlineblock "><strong>Eduardo Agüera-Morales</strong>, </span><span class="inlineblock "><strong>Ana B. Caminero</strong>, </span><span class="inlineblock "><strong>Sergio Martínez-Yélamos</strong>, </span><span class="inlineblock "><strong>Luis Querol</strong>, </span><span class="inlineblock "><strong>Nicolas Medrano</strong>, </span><span class="inlineblock "><strong>Rocío Gómez-Ballesteros</strong>, </span><span class="inlineblock "><strong>Luisa M. Villar</strong>, </span><span class="inlineblock "><strong>Enric Monreal</strong> and </span><span class="inlineblock "><strong>Gustavo Saposnik</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(2), 69; <a href="https://doi.org/10.3390/jpm15020069">https://doi.org/10.3390/jpm15020069</a> - 14 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Cognitive impairment has an impact upon the function and quality of life of patients with multiple sclerosis (MS). High-serum neurofilament light-chain (sNfL) levels predict disease progression and are also associated with impaired cognitive performance. This study aimed to assess the attitudes of <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/69/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Cognitive impairment has an impact upon the function and quality of life of patients with multiple sclerosis (MS). High-serum neurofilament light-chain (sNfL) levels predict disease progression and are also associated with impaired cognitive performance. This study aimed to assess the attitudes of neurologists toward sNfL testing as regards making therapeutic decisions in clinically and radiologically stable patients experiencing cognitive decline. <b>Methods:</b> A web-based observational study was conducted among neurologists caring for patients with MS. The role of sNfL in therapeutic decisions was assessed through a simulated case scenario describing a 31-year-old woman with relapsing–remitting MS for four years on glatiramer acetate. Her partner reported increased distractibility and difficulties in organizing daily activities over the past 18 months. There was no history of new relapses, and a follow-up brain MRI scan showed no new lesions. Her performance in the Symbol Digit Modalities Test decreased by 8 points from the previous year, with 46 correct answers. The patient had an sNfL level of 21 pg/mL, with no other identified factors that could have altered this value. The participants were tasked with deciding to either escalate treatment or to continue the current treatment and schedule the patient for reassessment in 6–12 months (defined as decisions misaligned with emerging evidence [DMEE]). Multivariate regression analysis was conducted to determine factors associated with DMEE. <b>Results:</b> One hundred and sixteen neurologists participated in the study. Almost 50% of the participants (<i>n</i> = 57) opted not to escalate treatment despite high sNfL levels. This was more common among neurologists not fully dedicated to MS care (60.5% vs. 43.6%). The multivariate analysis showed that being a neurologist not fully dedicated to MS (odds ratio [OR] = 2.35, 95% confidence interval [CI] 1.01–5.50; <i>p</i> = 0.04) and having a poor perception of sNfL benefits (OR = 1.02, 95% CI 1.00–1.04; <i>p</i> = 0.01) were associated with DMEE. <b>Conclusions:</b> Neurologists’ lack of full dedication to MS care and limited perception of sNfL’s clinical utility were key factors associated with suboptimal therapeutic decisions in a simulated case of cognitive decline with elevated sNfL. These findings underscore the need for increased education on the role of sNfL to improve evidence-based decision-making in MS management. <a href="/2075-4426/15/2/69">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jpm/sections/personalized_therapy_drug_delivery">Personalized Therapy and Drug Delivery</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1589546" aria-controls="drop-supplementary-1589546" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1589546" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2075-4426/15/2/68/s1?version=1739361087"> Supplementary File 1 (ZIP, 3853 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 11 pages, 862 KiB   </span> <a href="/2075-4426/15/2/68/pdf?version=1739361086" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="A Personalized Approach to Adhesion Prevention in Single-Port Access Laparoscopic Surgery: A Randomized Prospective Study Evaluating the Efficacy of Adhesion Barriers and Patient-Specific Risk Factors" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2075-4426/15/2/68">A Personalized Approach to Adhesion Prevention in Single-Port Access Laparoscopic Surgery: A Randomized Prospective Study Evaluating the Efficacy of Adhesion Barriers and Patient-Specific Risk Factors</a> <div class="authors"> by <span class="inlineblock "><strong>Seongyun Lim</strong>, </span><span class="inlineblock "><strong>Joseph Noh</strong>, </span><span class="inlineblock "><strong>Junhyeong Seo</strong>, </span><span class="inlineblock "><strong>Youngeun Chung</strong> and </span><span class="inlineblock "><strong>Taejoong Kim</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(2), 68; <a href="https://doi.org/10.3390/jpm15020068">https://doi.org/10.3390/jpm15020068</a> - 12 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>A</b><b>bstract: Background/Objectives</b>: Single-port access (SPA) laparoscopic surgery has gained popularity due to its cosmetic benefits and reduced postoperative pain. However, concerns persist regarding the increased risk of adhesions due to the larger umbilical incision. This study aims to contribute to personalized <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/68/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>A</b><b>bstract: Background/Objectives</b>: Single-port access (SPA) laparoscopic surgery has gained popularity due to its cosmetic benefits and reduced postoperative pain. However, concerns persist regarding the increased risk of adhesions due to the larger umbilical incision. This study aims to contribute to personalized medicine by evaluating the effectiveness of applying an anti-adhesive agent (Guardix SG<sup>®</sup>, HanmiPharmaceutical Co., Ltd., Seoul, Korea) at the umbilical incision and identifying patient-specific risk factors for adhesion formation in SPA laparoscopic surgeries. <b>Methods</b>: In this randomized prospective study, 55 female patients with benign gynecological conditions were enrolled. Participants were randomly assigned to either an intervention group, which received the anti-adhesive agent at both the surgical and umbilical sites, or a control group, which received it only at the surgical site. Participants returned for outpatient visits 1–3 months post-surgery to assess incision site complications, including adhesions. <b>Results</b>: The overall adhesion rate was 10.9%, with 13.3% in the control group and 8% in the intervention group, though the difference was not statistically significant (<i>p</i> = 0.678). Infection rates were 6.7% in the control group and 4% in the intervention group; however, there was no significant difference in complications. Logistic regression identified pre-existing adhesions as a significant risk factor (<i>p</i> = 0.0379; OR = 6.909). <b>Conclusions</b>: Although the adhesion barrier showed a trend toward reducing umbilical adhesions, the difference was not statistically significant. The application of the adhesion barrier did not influence incision site complications, confirming its safety. Our findings highlight the need for personalized approaches to adhesion prevention, considering individual patient characteristics and risk factors. Further larger studies are necessary to explore adhesion prevention in a more personalized manner for individual patients in this context. <a href="/2075-4426/15/2/68">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jpm/sections/Methodology_drug_device_discovery">Methodology, Drug and Device Discovery</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/68/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1589546"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1589546"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1589546" data-cycle-prev="#prev1589546" data-cycle-progressive="#images1589546" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1589546-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jpm/jpm-15-00068/article_deploy/html/images/jpm-15-00068-g001a-550.jpg?1739361176" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1589546" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1589546-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00068/article_deploy/html/images/jpm-15-00068-g001b-550.jpg?1739361178'><p>Figure 1 Cont.</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1589546-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00068/article_deploy/html/images/jpm-15-00068-g002-550.jpg?1739361180'><p>Figure 2</p></div></script></div></div><div id="article-1589546-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jpm/jpm-15-00068/article_deploy/html/images/jpm-15-00068-g001a-550.jpg?1739361176" title=" <strong>Figure 1</strong><br/> <p>Visceral sliding technique via trans-abdominal ultrasound. Visceral sliding distances during tidal and maximal respiration are relatively shorter in cases with adhesions. (<b>a</b>) Visceral sliding during tidal and maximal respiration in a patient without adhesions; (<b>b</b>) visceral sliding during tidal and maximal respiration in a patient with adhesions. (*) Rectus abdominis muscle, (Δ) visceral peritoneum; <a href="#app1-jpm-15-00068" class="html-app">Supplementary Video S1</a>.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/68'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00068/article_deploy/html/images/jpm-15-00068-g001b-550.jpg?1739361178" title=" <strong>Figure 1 Cont.</strong><br/> <p>Visceral sliding technique via trans-abdominal ultrasound. Visceral sliding distances during tidal and maximal respiration are relatively shorter in cases with adhesions. (<b>a</b>) Visceral sliding during tidal and maximal respiration in a patient without adhesions; (<b>b</b>) visceral sliding during tidal and maximal respiration in a patient with adhesions. (*) Rectus abdominis muscle, (Δ) visceral peritoneum; <a href="#app1-jpm-15-00068" class="html-app">Supplementary Video S1</a>.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/68'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00068/article_deploy/html/images/jpm-15-00068-g002-550.jpg?1739361180" title=" <strong>Figure 2</strong><br/> <p>Study flow chart. * Postoperative outcomes include postoperative adhesion, surgical site infection, and dehiscence.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/68'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 12 pages, 1035 KiB   </span> <a href="/2075-4426/15/2/67/pdf?version=1739349110" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Is CK7 a Prognostic Marker in Pulmonary LCNEC? Evidence from a Limited Cohort Study" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2075-4426/15/2/67">Is CK7 a Prognostic Marker in Pulmonary LCNEC? Evidence from a Limited Cohort Study</a> <div class="authors"> by <span class="inlineblock "><strong>Hruy Menghesha</strong>, </span><span class="inlineblock "><strong>Donatas Zalepugas</strong>, </span><span class="inlineblock "><strong>Amina Camo</strong>, </span><span class="inlineblock "><strong>Georg Schlachtenberger</strong>, </span><span class="inlineblock "><strong>Konstantinos Grapatsas</strong>, </span><span class="inlineblock "><strong>Andres Amorin Estremadoyro</strong>, </span><span class="inlineblock "><strong>Fabian Doerr</strong>, </span><span class="inlineblock "><strong>Matthias Heldwein</strong>, </span><span class="inlineblock "><strong>Alexander Quaas</strong>, </span><span class="inlineblock "><strong>Servet Bölükbas</strong>, </span><span class="inlineblock "><strong>Gerardus Bennink</strong>, </span><span class="inlineblock "><strong>Joachim Schmidt</strong> and </span><span class="inlineblock "><strong>Khosro Hekmat</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(2), 67; <a href="https://doi.org/10.3390/jpm15020067">https://doi.org/10.3390/jpm15020067</a> - 12 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Objectives:</b> While the treatment of non-small-cell lung carcinoma has improved rapidly, the treatment of pulmonary large-cell neuroendocrine carcinoma (LCNEC) remains underdeveloped. The use of immunohistochemistry allows for accurate risk stratification. With our study, we investigated the outcome of patients with pulmonary LCNEC and <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/67/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Objectives:</b> While the treatment of non-small-cell lung carcinoma has improved rapidly, the treatment of pulmonary large-cell neuroendocrine carcinoma (LCNEC) remains underdeveloped. The use of immunohistochemistry allows for accurate risk stratification. With our study, we investigated the outcome of patients with pulmonary LCNEC and analyzed whether CK7 correlates with long-term survival. <b>Methods:</b> We retrospectively collected the monocentric data of patients which underwent anatomical resection for lung cancer between January 2012 and December 2020. Patients that did not show pulmonary LCNEC or adenocarcinoma, had a positive resection margin, or underwent neoadjuvant therapy were excluded. The long-term survival rate of the LCNEC and adenocarcinoma groups were compared before and after propensity score matching. Furthermore, we performed survival analyses for a subgroup of LCNEC distinguished by CK7 expression, followed by Cox regression analyses. <b>Results:</b> A total of 466 patients were integrated for further analysis. The mean age was 65.3 ± 9.6 years. There were no significant differences between both groups regarding age, gender, or comorbidities. In terms of the UICC stage, the groups were equally distributed. Mean survival in the LCNEC group was significantly worse than in the adenocarcinoma group (LCENC: 36.4 ± 7.5 months; adenocarcinoma: 80.7 ± 8.1 months; <i>p</i>-value = 0.001). The mean survival rate was 19.23 ± 4.8 months in the CK7 expression group and 57.01 ± 8.5 months in the group without expression, which reached statistical significance (<i>p</i>-value = 0.019). <b>Conclusions:</b> Our study suggests that pulmonary LCNEC has a significantly worse prognosis than pulmonary adenocarcinoma. CK7 expression seems to be correlated with a worse outcome for the long-term survival rate of patients suffering from highly malignant pulmonary LCNEC. <a href="/2075-4426/15/2/67">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jpm/special_issues/43G6CUM027 ">Personalized Treatments in Thoracic Oncology Surgery</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/67/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="arrow left-arrow" id="prev1589226"><i class="fa fa-caret-left"></i></div><div class="arrow right-arrow" id="next1589226"><i class="fa fa-caret-right"></i></div><div class="absgraph cycle-slideshow manual" data-cycle-fx="scrollHorz" data-cycle-timeout="0" data-cycle-next="#next1589226" data-cycle-prev="#prev1589226" data-cycle-progressive="#images1589226" data-cycle-slides=">div" data-cycle-log="false"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1589226-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jpm/jpm-15-00067/article_deploy/html/images/jpm-15-00067-g001-550.jpg?1739349208" alt="" style="border: 0;"><p>Figure 1</p></div><script id="images1589226" type="text/cycle" data-cycle-split="---"><div class='openpopupgallery' data-imgindex='1' data-target='article-1589226-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00067/article_deploy/html/images/jpm-15-00067-g002-550.jpg?1739349209'><p>Figure 2</p></div> --- <div class='openpopupgallery' data-imgindex='2' data-target='article-1589226-popup'><span class="helper"></span><img src='https://pub.mdpi-res.com/jpm/jpm-15-00067/article_deploy/html/images/jpm-15-00067-g003-550.jpg?1739349210'><p>Figure 3</p></div></script></div></div><div id="article-1589226-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jpm/jpm-15-00067/article_deploy/html/images/jpm-15-00067-g001-550.jpg?1739349208" title=" <strong>Figure 1</strong><br/> <p>Overall survival before PSM.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/67'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00067/article_deploy/html/images/jpm-15-00067-g002-550.jpg?1739349209" title=" <strong>Figure 2</strong><br/> <p>Overall survival after PSM.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/67'>Full article</a></strong> "></a><a href="https://pub.mdpi-res.com/jpm/jpm-15-00067/article_deploy/html/images/jpm-15-00067-g003-550.jpg?1739349210" title=" <strong>Figure 3</strong><br/> <p>Subgroup analysis of LCNEC distinguished by CK7 status.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/67'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <a data-dropdown="drop-supplementary-1588429" aria-controls="drop-supplementary-1588429" aria-expanded="false" title="Supplementary Material"> <i class="material-icons">attachment</i> </a> <div id="drop-supplementary-1588429" class="f-dropdown label__btn__dropdown label__btn__dropdown--wide" data-dropdown-content aria-hidden="true" tabindex="-1"> Supplementary material: <br/> <a href="/2075-4426/15/2/66/s1?version=1739265994"> Supplementary File 1 (ZIP, 154 KiB) </a><br/> </div> </div> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 13 pages, 535 KiB   </span> <a href="/2075-4426/15/2/66/pdf?version=1739265993" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Treatments of Interest in Male Breast Cancer: An Umbrella Review" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Systematic Review</span></div> <a class="title-link" href="/2075-4426/15/2/66">Treatments of Interest in Male Breast Cancer: An Umbrella Review</a> <div class="authors"> by <span class="inlineblock "><strong>Stefano Spinaci</strong>, </span><span class="inlineblock "><strong>Luca Arecco</strong>, </span><span class="inlineblock "><strong>Agnese Anedda</strong>, </span><span class="inlineblock "><strong>Lucia Martino</strong>, </span><span class="inlineblock "><strong>Emma Firpo</strong>, </span><span class="inlineblock "><strong>Matteo Ghilli</strong>, </span><span class="inlineblock "><strong>Matteo Lambertini</strong> and </span><span class="inlineblock "><strong>Giulia Ferrarazzo</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(2), 66; <a href="https://doi.org/10.3390/jpm15020066">https://doi.org/10.3390/jpm15020066</a> - 11 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Male breast cancer (MaBC) is a rare disease and due to its rarity and the lack of specific protocols for its management, treatment algorithms are extrapolated from female breast cancer (FBC). To optimize MaBC treatment, we conceived an umbrella review with the <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/66/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Male breast cancer (MaBC) is a rare disease and due to its rarity and the lack of specific protocols for its management, treatment algorithms are extrapolated from female breast cancer (FBC). To optimize MaBC treatment, we conceived an umbrella review with the aim of supplying an evidence-based summary of systematic reviews published about this topic in the last twenty years. <b>Methods:</b> This umbrella review was performed according to a predefined protocol (PROSPERO number CRD42024574299). We performed a literature search of the PubMed and Cochrane Libraries databases and we considered systematic reviews on MaBC treatment published from 2004 to 2024. We evaluated relevant treatments in the management of MaBC, including surgery, radiotherapy, and systemic treatments. We conducted the quality assessment according to A MeaSurement Tool to Assess systematic Reviews version 2 (AMSTAR-2), and the description of the main findings of eligible articles. <b>Results:</b> Seven systematic reviews were selected and the main findings were compiled. Breast-conserving surgery is a reasonable treatment approach and, in selected cases, equivalent in terms of safety and survival outcomes compared to mastectomy. Sentinel lymph node biopsy represents a successful surgical practice with similar accuracy compared to female cases. Adjuvant radiotherapy improves overall survival in MaBC patients following partial mastectomy and after radical mastectomy, in case of involved nodes. Finally, Tamoxifen is associated with an improvement of survival outcomes; aromatase inhibitor and gonadotrophin-releasing hormone should be used only in case of contraindications to tamoxifen. <b>Conclusions:</b> Further research and improved guidelines for MaBC treatment should consider these evidence-based data. <a href="/2075-4426/15/2/66">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jpm/special_issues/K83659OLEQ ">Breast Cancer: Current Trends and Future Challenges in Evaluation and Treatment</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/66/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="absgraph cycle-slideshow"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1588429-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jpm/jpm-15-00066/article_deploy/html/images/jpm-15-00066-g001-550.jpg?1739266216" alt="" style="border: 0;"><p>Figure 1</p></div></div></div><div id="article-1588429-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jpm/jpm-15-00066/article_deploy/html/images/jpm-15-00066-g001-550.jpg?1739266216" title=" <strong>Figure 1</strong><br/> <p>Flow of records searched according to the present systematic review.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/66'>Full article</a></strong> "></a></div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 19 pages, 330 KiB   </span> <a href="/2075-4426/15/2/65/pdf?version=1739179179" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Occlusion and Biomechanical Risk Factors in Implant-Supported Full-Arch Fixed Dental Prostheses—Narrative Review" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Review</span></div> <a class="title-link" href="/2075-4426/15/2/65">Occlusion and Biomechanical Risk Factors in Implant-Supported Full-Arch Fixed Dental Prostheses—Narrative Review</a> <div class="authors"> by <span class="inlineblock "><strong>Andrea Berzaghi</strong>, </span><span class="inlineblock "><strong>Tiziano Testori</strong>, </span><span class="inlineblock "><strong>Riccardo Scaini</strong> and </span><span class="inlineblock "><strong>Sergio Bortolini</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(2), 65; <a href="https://doi.org/10.3390/jpm15020065">https://doi.org/10.3390/jpm15020065</a> - 7 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> The biophysiological differences between teeth and dental implants and the issue of occlusal overload, although controversial, form the basis for the management of occlusion in implant-supported full-arch fixed dental prostheses (ISFAFDPs). Although there is currently a lack of scientific evidence on occlusal management, <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/65/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> The biophysiological differences between teeth and dental implants and the issue of occlusal overload, although controversial, form the basis for the management of occlusion in implant-supported full-arch fixed dental prostheses (ISFAFDPs). Although there is currently a lack of scientific evidence on occlusal management, it is clear that the favorable prognosis of ISFAFDPs is linked to a correct understanding of the biomechanical principles involved. In the design of ISFAFDPs, the lack of proprioceptive feedback requires special attention to biomechanical factors: minimizing overloading complications and providing biomechanical stability are among the main goals of the occlusion. In ISFAFDPs, the occlusion must be decided on the basis of several factors that influence the loads on prosthesis and implants: each case must be evaluated individually and requires a personalized occlusion. The main aim of this narrative review is to provide an overview of the occlusal principles and materials that can be used in ISFAFDPs based on the data currently available in the literature. Practical clinical recommendations for the occlusion management of ISFAFDPs and a biomechanical risk score index to personalize implant-prosthetic treatment are proposed. <a href="/2075-4426/15/2/65">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Special Issue <a href=" /journal/jpm/special_issues/HR5RE92782 ">Personalized Medicine in Dental and Oral Health</a>)<br/> </div> </div> </div> </div> <div class="expanding-div collapsed"> <div class="generic-item article-item"> <div class="article-content"> <div class="label right label__btn"> <span style="font-size: 12px; color: #1a1a1a;"> 10 pages, 333 KiB   </span> <a href="/2075-4426/15/2/64/pdf?version=1738935791" class="UD_Listings_ArticlePDF" title="Article PDF" data-name="Efficacy and Safety of Omalizumab and Dupilumab in Pediatric Patients with Skin Diseases: An Observational Study" data-journal="jpm"> <i class="material-icons custom-download"></i> </a> </div> <div class="article-icons"><span class="label openaccess" data-dropdown="drop-article-label-openaccess" aria-expanded="false">Open Access</span><span class="label articletype">Article</span></div> <a class="title-link" href="/2075-4426/15/2/64">Efficacy and Safety of Omalizumab and Dupilumab in Pediatric Patients with Skin Diseases: An Observational Study</a> <div class="authors"> by <span class="inlineblock "><strong>Francesca Galletta</strong>, </span><span class="inlineblock "><strong>Ludovica Rizzuti</strong>, </span><span class="inlineblock "><strong>Stefano Passanisi</strong>, </span><span class="inlineblock "><strong>Emanuela Rosa</strong>, </span><span class="inlineblock "><strong>Lucia Caminiti</strong> and </span><span class="inlineblock "><strong>Sara Manti</strong></span> </div> <div class="color-grey-dark"> <em>J. Pers. Med.</em> <b>2025</b>, <em>15</em>(2), 64; <a href="https://doi.org/10.3390/jpm15020064">https://doi.org/10.3390/jpm15020064</a> - 7 Feb 2025 </div> <div class="abstract-div"> <a href="#" onclick="$(this).next('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> <strong>Abstract </strong> </a> <div class="abstract-cropped inline"> <b>Background:</b> Chronic spontaneous urticaria (CSU) and moderate-to-severe atopic dermatitis (AD) are significant challenges in pediatric populations, negatively impacting quality of life (QoL). Biologic therapies, including omalizumab and dupilumab, showed considerable promise for patients unresponsive to conventional treatments. This study evaluated the real-life efficacy <a href="#" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/64/more" onclick="$(this).parents('.abstract-cropped').toggleClass('inline').next('.abstract-full').toggleClass('inline'); return false;"> [...] Read more.</a> </div> <div class="abstract-full "> <b>Background:</b> Chronic spontaneous urticaria (CSU) and moderate-to-severe atopic dermatitis (AD) are significant challenges in pediatric populations, negatively impacting quality of life (QoL). Biologic therapies, including omalizumab and dupilumab, showed considerable promise for patients unresponsive to conventional treatments. This study evaluated the real-life efficacy and safety of these biologics in pediatric CSU and AD patients. <b>Methods:</b> A retrospective, monocentric study was conducted enrolling pediatric patients (aged 6–18 years) followed at the “G. Martino” Hospital, University of Messina. This study included patients with CSU unresponsive to antihistamines and those with moderate-to-severe AD refractory to topical therapies. Disease severity and treatment efficacy were evaluated using the Urticaria Activity Score 7 (UAS7) for CSU, the Eczema Area and Severity Index (EASI) for AD, and QoL metrics, including the Dermatology Life Quality Index (DLQI) and numerical rating scales, for pruritus (p-NRS) and sleep (s-NRS), at baseline, 16 weeks, and 52 weeks. Safety was assessed through the monitoring of reported adverse events (AEs). <b>Results:</b> Omalizumab significantly reduced UAS7 scores by 71.9% at 16 weeks and 75.3% at 52 weeks (<i>p</i> < 0.001), with concurrent improvements in c-DLQI. Dupilumab reduced the EASI score by 75.3%, p-NRS by 40%, and s-NRS by 52.9% over 52 weeks, with c-DLQI improving by 72.6%. No severe AEs were observed; mild reactions included injection-site erythema and respiratory symptoms. <b>Conclusions:</b> Omalizumab and dupilumab demonstrated significant efficacy in reducing disease severity and improving QoL in pediatric patients with CSU and AD. Moreover, their safety profile underscores their potential as essential treatments for these conditions. <a href="/2075-4426/15/2/64">Full article</a> </div> </div> <div class="belongsTo" style="margin-bottom: 10px;"> (This article belongs to the Section <a href="/journal/jpm/sections/clinical_medicine_cell_organism_physiology">Clinical Medicine, Cell, and Organism Physiology</a>)<br/> </div> <a href="#" class="abstract-figures-show" data-counterslink = "https://www.mdpi.com/2075-4426/15/2/64/show" ><span >►</span><span style=" display: none;">▼</span> Show Figures </a><div class="abstract-image-preview "><div class="absgraph cycle-slideshow"><div class='openpopupgallery cycle-slide' data-imgindex='0' data-target='article-1585945-popup'><span class="helper"></span><img src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://pub.mdpi-res.com/jpm/jpm-15-00064/article_deploy/html/images/jpm-15-00064-g001-550.jpg?1738935867" alt="" style="border: 0;"><p>Figure 1</p></div></div></div><div id="article-1585945-popup" class="popupgallery" style="display: inline; line-height: 200%"><a href="https://pub.mdpi-res.com/jpm/jpm-15-00064/article_deploy/html/images/jpm-15-00064-g001-550.jpg?1738935867" title=" <strong>Figure 1</strong><br/> <p>Changes in clinical scores across the study period; <span class="html-italic">p</span>-value &lt; 0.001.</p> <strong style='display: block; margin-top: 10px; font-size: 18px;'><a style='color: #fff' href='/2075-4426/15/2/64'>Full article</a></strong> "></a></div> </div> </div> </div> </div> <div class="generic-item last-item"> <a class="bold" href="/search?q=&journal=jpm&sort=pubdate&page_count=50">More Articles...</a> </div> </div> </div> </div> <div id="left-column" class="content__column large-3 large-pull-6 medium-3 medium-pull-6 small-12 columns"> <div id="js-large-main-top-container"> <div id="js-main-top-container" class="content__container"> <a href="/journal/jpm"> <img 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