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However, the recurrent event process is often interrupted by a dependent terminal event, such as death. In this article, we propose a joint modeling approach for analyzing marker data with informative recurrent and terminal events. This approach introduces a shared frailty to specify the explicit dependence structure among the markers, the recurrent, and terminal events. Estimation procedures are developed for the model parameters and the degree of dependence, and a prediction of the covariate-specific cumulative markers is provided. The finite sample performance of the proposed estimators is examined through simulation studies. An application to a medical cost study of chronic heart failure patients from the University of Virginia Health System is illustrated.<br class="zbmathjax-paragraph">{&copy; 2020 The International Biometric Society}</div> <div class="clear"></div> <div class="classification"> <h3>MSC:</h3> <table><tr> <td> <a class="mono" href="/classification/?q=cc%3A62P10" title="MSC2020">62P10</a> </td> <td class="space"> Applications of statistics to biology and medical sciences; meta analysis </td> </tr></table> </div><div class="keywords"> <h3>Keywords:</h3><a href="/?q=ut%3Ajoint+modeling">joint modeling</a>; <a href="/?q=ut%3Alongitudinal+data+analysis">longitudinal data analysis</a>; <a href="/?q=ut%3Amarker+process">marker process</a>; <a href="/?q=ut%3Amedical+costs">medical costs</a>; <a href="/?q=ut%3Arecurrent+events">recurrent events</a>; <a href="/?q=ut%3Aterminal+event">terminal event</a></div> <!-- Modal used to show zbmath metadata in different output formats--> <div class="modal fade" id="metadataModal" tabindex="-1" role="dialog" aria-labelledby="myModalLabel"> <div class="modal-dialog" role="document"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">&times;</span></button> <h4 class="modal-title" id="myModalLabel">Cite</h4> </div> <div class="modal-body"> <div class="form-group"> <label for="select-output" class="control-label">Format</label> <select id="select-output" class="form-control" aria-label="Select Metadata format"></select> </div> <div class="form-group"> <label for="metadataText" class="control-label">Result</label> <textarea class="form-control" id="metadataText" rows="10" style="min-width: 100%;max-width: 100%"></textarea> </div> <div id="metadata-alert" class="alert alert-danger" role="alert" style="display: none;"> <!-- alert for connection errors etc --> </div> </div> <div class="modal-footer"> <button type="button" class="btn btn-primary" onclick="copyMetadata()">Copy to clipboard</button> <button type="button" class="btn btn-default" data-dismiss="modal">Close</button> </div> </div> </div> </div> <div class="functions clearfix"> <div class="function"> <!-- Button trigger metadata modal --> <a type="button" class="btn btn-default btn-xs pdf" data-toggle="modal" data-target="#metadataModal" data-itemtype="Zbl" data-itemname="Zbl 1520.62415" data-ciurl="/ci/07747560" data-biburl="/bibtex/07747560.bib" data-amsurl="/amsrefs/07747560.bib" data-xmlurl="/xml/07747560.xml" > Cite </a> <a class="btn btn-default btn-xs pdf" data-container="body" type="button" href="/pdf/07747560.pdf" title="Zbl 1520.62415 as PDF">Review PDF</a> </div> <div class="fulltexts"> <span class="fulltext">Full Text:</span> <a class="btn btn-default btn-xs" type="button" href="https://doi.org/10.1111/biom.13260" aria-label="DOI for “A joint modeling approach for analyzing marker data in the presence of a terminal event”" title="10.1111/biom.13260">DOI</a> </div> <div class="sfx" style="float: right;"> </div> </div> <div class="references"> <h3>References:</h3> <table><tr> <td>[1]</td> <td class="space">Bang, H.; Tsiatis, A. A., Median regression with censored cost data, Biometrics, 58, 643-649, 2002 &middot; <a href="/1210.62041" class="nowrap">Zbl 1210.62041</a></td> </tr><tr> <td>[2]</td> <td class="space">Cai, J.; Zeng, D.; Pan, W., Semiparametric proportional means model for marker data contingent on recurrent event, Lifetime Data Analysis, 16, 250-270, 2010 &middot; <a href="/1322.62305" class="nowrap">Zbl 1322.62305</a></td> </tr><tr> <td>[3]</td> <td class="space">Cai, Q.; Wang, M.‐C.; Chan, K. C.G., Joint modeling of longitudinal, recurrent events and failure time data for survivor&rsquo;s population, Biometrics, 73, 1150-1160, 2017 &middot; <a href="/1405.62161" class="nowrap">Zbl 1405.62161</a></td> </tr><tr> <td>[4]</td> <td class="space">Chan, K. 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L., Estimating the mean of an increasing stochastic process at a censored stopping time, Journal of the American Statistical Association, 95, 1192-1208, 2000 &middot; <a href="/1008.62098" class="nowrap">Zbl 1008.62098</a></td> </tr><tr> <td>[19]</td> <td class="space">Sun, L.; Song, X.; Zhou, J.; Liu, L., Joint analysis of longitudinal data with informative observation times and a dependent terminal event, Journal of the American Statistical Association, 107, 688-700, 2012 &middot; <a href="/1261.62090" class="nowrap">Zbl 1261.62090</a></td> </tr><tr> <td>[20]</td> <td class="space">Sun, Y.; Gilbert, P. B.; McKeague, I. W., Proportional hazards models with continuous marks, The Annals of Statistics, 37, 394-426, 2009 &middot; <a href="/1155.62075" class="nowrap">Zbl 1155.62075</a></td> </tr><tr> <td>[21]</td> <td class="space">Sun, Y.; Huang, C.‐Y.; Wang, M.‐C., Nonparametric benefit-risk assessment using marker process in the presence of a terminal event, Journal of the American Statistical Association, 112, 826-836, 2017</td> </tr><tr> <td>[22]</td> <td class="space">Sun, Y.; Wang, M.‐C., Evaluating utility measurement from recurrent marker processes in the presence of competing terminal events, Journal of the American Statistical Association, 112, 745-756, 2017</td> </tr></table> <div class="reference_disclaimer"> This reference list is based on information provided by the publisher or from digital mathematics libraries. Its items are heuristically matched to zbMATH identifiers and may contain data conversion errors. In some cases that data have been complemented/enhanced by data from zbMATH&nbsp;Open. This attempts to reflect the references listed in the original paper as accurately as possible without claiming completeness or a perfect matching. </div> </div></article> </div></div> </div> </div> <div class="clearfix"></div> </div> </div> <div id="foot"><div class="copyright"> &copy; 2025 <a target="fiz" href="https://www.fiz-karlsruhe.de/en">FIZ Karlsruhe GmbH</a> <a href="/privacy-policy/">Privacy Policy</a> <a href="/legal-notices/">Legal Notices</a> <a href="/terms-conditions/">Terms &amp; Conditions</a> <div class="info"> <ul class="nav"> <li class="mastodon"> <a href="https://mathstodon.xyz/@zbMATH" target="_blank" class="no-new-tab-icon"> <img src="/static/mastodon.png" title="zbMATH at Mathstodon (opens in new tab)" alt="Mastodon logo"> </a> </li> </ul> </div> </div> <div class="clearfix" style="height: 0px;"></div> </div> </div> <script src="https://static.zbmath.org/contrib/jquery/1.9.1/jquery.min.js"></script> <script src="https://static.zbmath.org/contrib/jquery-caret/1.5.2/jquery.caret.min.js"></script> <script src="/static/js/jquery-ui-1.10.1.custom.min.js"></script> <script src="https://static.zbmath.org/contrib/bootstrap/v3.3.7zb1/js/bootstrap.min.js"></script> <script src="https://static.zbmath.org/contrib/bootstrap-lightbox/v0.7.0/bootstrap-lightbox.min.js"></script> <script src="https://static.zbmath.org/contrib/retina/unknown/retina.js"></script> <script src="https://static.zbmath.org/contrib/bootstrap-select/v1.13.14/js/bootstrap-select.min.js"></script> <script> var SCRIPT_ROOT = ""; </script> <script src="/static/scripts.js?v=20240926"> </script> <script src="https://static.zbmath.org/contrib/mathjax/2.7.1/MathJax.js?config=TeX-AMS-MML_HTMLorMML"></script> <script type="text/x-mathjax-config"> MathJax.Hub.Config({ "HTML-CSS": { preferredFont: "TeX", availableFonts: [ "STIX", "TeX" ], linebreaks: { automatic: true }, EqnChunk: (MathJax.Hub.Browser.isMobile ? 10 : 50) }, tex2jax: { processEscapes: true, ignoreClass: "tex2jax_ignore|dno" }, TeX: { Macros: { Aut: "\\operatorname{Aut}", Hom: "\\operatorname{Hom}" }, noUndefined: { attributes: { mathcolor: "#039", //"red", mathbackground: "white", //"#FFEEEE", mathsize: "90%" } } }, messageStyle: "none" }); </script> <script type="text/javascript"> $(document).ready(function() { $("#MathInput").stop(true, true).keyup(function() { $.ajax({ url: "/mwsq/", type: "POST", data: { query : $("#MathInput").val() }, dataType: "text" }) .done(function(xml) { $("#MathPreview").html(xml); $(window).resize(); }); }); var press = jQuery.Event("keyup"); press.ctrlKey = false; press.which = 40; $("#MathInput").trigger(press); }); </script> <div id="new_tab_icon" style="display: none">&nbsp;<span class="glyphicon glyphicon-new-window" aria-hidden="true"></span><span class="sr-only">(opens in new tab)</span></div> </body> </html>

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