TNF-alpha Products

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<div class="highlighted"> <aside class="container section clearfix" role="complementary"> <div> </div> </aside> </div> <div id="main" class="container-fluid container-wide "> <div class="row"> <div class="col-md-12"> <div> <div id="block-bio-techne-global-breadcrumbs" class="system_breadcrumb_block"> <nav role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> Products </li> <li> TNF-alpha Products </li> </ol> </nav> </div> </div> </div> </div> <div class="row"> <div class="col-md-12"> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <div id="search_results_page"> <div class="d-sm-block d-xs-block d-lg-none d-xl-none"> <div class="d-lg-none"> <h1>TNF-alpha Products</h1> <div class="show-more" data-text="<p>TNF-alpha (Tumor necrosis factor alpha) plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. TNF-alpha was first identified as a cytotoxic factor produced by macrophages capable of killing mouse tumor cells.&nbsp;It is the prototypic ligand and along with Lymphotoxin-alpha, were identified as the first members of the TNF superfamily. Active TNF-alpha and other members of the TNF superfamily exist as a homotrimer with high structural homology. Receptor binding occurs at the interface of two TNF-alpha monomers. And receptor activation occurs when all three monomer interfaces are engaged with a receptor. For TNF-alpha, receptor binding and activation occurs through TNF R1 or TNF RII, and subsequently leads to activation of NF-kB or MAPK signaling pathways. Another pathway that TNF-alpha can activate utilizes the death domain of TNF RI to induce apoptosis. TNF-alpha promotes the inflammatory response largely through NF-kB signaling, and inhibition of TNF-alpha has proven successful in treating many autoimmune disorders. TNF-alpha is also present on the cell surface as membrane-bound TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells. TNF-alpha protein is translated as a type II transmembrane protein containing an N-terminal transmembrane domain. The soluble cytokine is released from its cell-anchoring TM domain by proteolytic processing by metalloproteases.</p>"> <div class="data-display"> <p>TNF-alpha (Tumor necrosis factor alpha) plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. TNF-alpha was first identified as a cytotoxic factor produced by macrophages capable of killing mouse tumor cells. It is the prototypic ligand and along with Lymphotoxin-alpha, were identified as the first members of the TNF superfamily. Active TNF-alpha and other members of the TNF superfamily exist as a homotrimer with high structural homology. Receptor binding occurs at the interface of two TNF-alpha monomers. And receptor activation occurs when all three monomer interfaces are engaged with a receptor. For TNF-alpha, receptor binding and activation occurs through TNF R1 or TNF RII, and subsequently leads to activation of NF-kB or MAPK signaling pathways. Another pathway that TNF-alpha can activate utilizes the death domain of TNF RI to induce apoptosis. TNF-alpha promotes the inflammatory response largely through NF-kB signaling, and inhibition of TNF-alpha has proven successful in treating many autoimmune disorders. TNF-alpha is also present on the cell surface as membrane-bound TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells. TNF-alpha protein is translated as a type II transmembrane protein containing an N-terminal transmembrane domain. 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<span class="searchImage_star4"></span> 4 & up (6) </span> </a> </div> </div> </div> </div> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button class="btn btn-secondary dropdown-toggle more-facet" type="button" id="dropdown-menu-button-gene_symbol" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Gene Symbol </button> <div class="dropdown-menu" aria-labelledby="dropdown-menu-button-gene_symbol"> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?host=Goat&gene_symbol=TNF" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="TNF (20)" data-facet_lower="tnf" class="search_facet_name text-break gene_symbol"> TNF <span class="facet_count">(20)</span> </span> </a> </div> </div> </div> </div> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button 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brand"> Novus Biologicals <span class="facet_count">(1)</span> </span> </a> </div> </div> </div> </div> <div class="text-center mx-2 my-2"> <a href="#" id="show-more-less-facets" class="d-inline font-weight-bold h5">Show More</a> </div> </div> </div> </div> </div> <div class="row"> <div class="col-md-6 d-none d-lg-block"> <p> <span class="search_num_results" data-search_results="20">20 results</span> for "<span class="search_term_text">TNF-alpha</span>" in <strong id="search_category">Products</strong> </p> </div> <div class="col-md-6 text-lg-right"> <label for="sort_by_select">Sort by:</label> <select id="sort_by_select" class="sort_by_select rounded-0 p-0" aria-label="Sort by"> <option value="/t/tnf-alpha?host=Goat&sort=ranking,desc" selected="selected" >Best Match </option> <option value="/t/tnf-alpha?host=Goat&sort=title,asc" >Products (A-Z) </option> <option value="/t/tnf-alpha?host=Goat&sort=product_created_date,desc" >Newest </option> <option value="/t/tnf-alpha?host=Goat&sort=stars,desc" >Rating </option> </select> </div> </div> <div id="search_results" class="row mt-3" data-search_term="TNF-alpha"> <div class="col-lg-12"> <div class="d-none d-lg-block"> <p class="target_h1">TNF-alpha Products</p> <div class="show-more" data-text="<p>TNF-alpha (Tumor necrosis factor alpha) plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. TNF-alpha was first identified as a cytotoxic factor produced by macrophages capable of killing mouse tumor cells.&nbsp;It is the prototypic ligand and along with Lymphotoxin-alpha, were identified as the first members of the TNF superfamily. Active TNF-alpha and other members of the TNF superfamily exist as a homotrimer with high structural homology. Receptor binding occurs at the interface of two TNF-alpha monomers. And receptor activation occurs when all three monomer interfaces are engaged with a receptor. For TNF-alpha, receptor binding and activation occurs through TNF R1 or TNF RII, and subsequently leads to activation of NF-kB or MAPK signaling pathways. Another pathway that TNF-alpha can activate utilizes the death domain of TNF RI to induce apoptosis. TNF-alpha promotes the inflammatory response largely through NF-kB signaling, and inhibition of TNF-alpha has proven successful in treating many autoimmune disorders. TNF-alpha is also present on the cell surface as membrane-bound TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells. TNF-alpha protein is translated as a type II transmembrane protein containing an N-terminal transmembrane domain. The soluble cytokine is released from its cell-anchoring TM domain by proteolytic processing by metalloproteases.</p>"> <div class="data-display"> <p>TNF-alpha (Tumor necrosis factor alpha) plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. TNF-alpha was first identified as a cytotoxic factor produced by macrophages capable of killing mouse tumor cells. It is the prototypic ligand and along with Lymphotoxin-alpha, were identified as the first members of the TNF superfamily. Active TNF-alpha and other members of the TNF superfamily exist as a homotrimer with high structural homology. Receptor binding occurs at the interface of two TNF-alpha monomers. And receptor activation occurs when all three monomer interfaces are engaged with a receptor. For TNF-alpha, receptor binding and activation occurs through TNF R1 or TNF RII, and subsequently leads to activation of NF-kB or MAPK signaling pathways. Another pathway that TNF-alpha can activate utilizes the death domain of TNF RI to induce apoptosis. TNF-alpha promotes the inflammatory response largely through NF-kB signaling, and inhibition of TNF-alpha has proven successful in treating many autoimmune disorders. TNF-alpha is also present on the cell surface as membrane-bound TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells. TNF-alpha protein is translated as a type II transmembrane protein containing an N-terminal transmembrane domain. The soluble cytokine is released from its cell-anchoring TM domain by proteolytic processing by metalloproteases.</p> </div> <a href="#" class="show-more-btn">Show More</a> </div> </div> <div id="search_results_selected_facets" class="my-2"> <div id="search_results_selected_facet_legend" class="d-inline-block"> Filters: </div> <a class="search_results_selected_facet mx-1 py-1 px-2 clear_facet btn btn-default" href="/t/tnf-alpha" rel="nofollow"> Host: Goat </a> <a href="/t/tnf-alpha" id="clear_filters">Clear All <strong>X</strong></a> </div> <div id="search_results_block"> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="AF-410-NA" data-name="Human/Mouse TNF-alpha Antibody" data-position="0"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/human-mouse-tnf-alpha-antibody_af-410-na" title="Human/Mouse TNF-alpha Antibody"> <h4>Human/Mouse TNF-alpha Antibody <span class="rounded align-middle p-1 badge best-seller" title="Best Seller">Best Seller</span> </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/human-mouse-tnf-alpha-antibody_af-410-na" title="Human/Mouse TNF-alpha Antibody"> AF-410-NA </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/human-mouse-tnf-alpha-antibody_af-410-na#reviews" class="searchImage_star4"> (5) </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/human-mouse-tnf-alpha-antibody_af-410-na#citations"><span class="icon-icon-product-citations"></span>Citations (152)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/human-mouse-tnf-alpha-antibody_af-410-na#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (8)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB, IHC, CyTOF-ready, ICC, ICFlow, Neut </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Human, Mouse </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-0" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-0"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Human, Mouse </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB, IHC, CyTOF-ready, ICC, ICFlow, +1 More </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="af-410-na"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/antibody/TNFalpha_AF410NA_Western_Blot_22812.jpg data-srcset=https://resources.bio-techne.com/images/products/antibody/TNFalpha_AF410NA_Western_Blot_22812.jpg alt="Detection of Human TNF-a antibody by Western Blot." title="Detection of Human TNF‑ alpha by Western Blot." data-caption="Western blot shows conditioned media from CHO Chinese hamster ovary cell line either mock transfected or transfected with human TNF- alpha. PVDF membrane was probed with 2 µg/mL of Goat Anti-Human/Mouse TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-410-NA) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). Specific bands were detected for TNF-a at approximately 14 and 17 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." data-badges="" data-application="Western Blot" data-header="Human/Mouse TNF-alpha Antibody, Catalog # AF-410-NA" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> <span class="image-count-text align-middle">(8)</span> </div> </div> </div> <i data-src="https://resources.bio-techne.com/images/products/antibody/TNFalpha_AF410NA_Western_Blot_22813.jpg" data-alt="Detection of Mouse TNF-a antibody by Western Blot." title="Detection of Mouse TNF‑ alpha by Western Blot." data-caption="Western blot shows lysates of RAW 264.7 mouse monocyte/macrophage cell line untreated (-) or treated (+) with 10 µg/mL LPS for 4 hours. PVDF membrane was probed with 2 µg/mL of Goat Anti-Human/Mouse TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-410-NA) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). Specific bands were detected for TNF-a at approximately 14 and 17 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." data-badges="<span class="biological-validation"></span>" data-application="Western Blot" data-header="Human/Mouse TNF-alpha Antibody, Catalog # AF-410-NA" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AF-410-NA_Immunocytochemistry_9636.jpg" data-alt="TNF-a antibody in RAW 264 by Immunocytochemistry (ICC).7 Mouse Cell Line by Immunocytochemistry (ICC)." title="TNF‑ alpha in RAW 264.7 Mouse Cell Line." data-caption="TNF-a was detected in immersion fixed RAW 264.7 mouse monocyte/ macrophage cell line treated with LPS using Human/Mouse TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-410-NA) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips." data-badges="<span class="biological-validation"></span>" data-application="Immunocytochemistry" data-header="Human/Mouse TNF-alpha Antibody, Catalog # AF-410-NA" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AF-410-NA_Immunocytochemistry_7296.jpg" data-alt="TNF-a antibody in Mouse T Cells by Immunocytochemistry (ICC)." title="TNF‑ alpha in Mouse T Cells." data-caption="TNF‑ alpha was detected in immersion fixed activated mouse T Cells using 15 µg/mL Human/Mouse TNF‑ alpha Antigen Affinity-purified Polyclonal Antibody (Catalog # AF‑410‑NA) for 3 hours at room temperature. Cells were stained (red) and counterstained (green). View our protocol for Fluorescent ICC Staining of Non-adherent Cells." data-badges="" data-application="Immunocytochemistry" data-header="Human/Mouse TNF-alpha Antibody, Catalog # AF-410-NA" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/antibody/af-410-na_mouse-tnf-alpha-affinity-purified-polyclonal-ab-immunohistochemistry-3520201707.jpg" data-alt="TNF-alpha antibody in Mouse Spleen Tissue by Immunohistochemistry (IHC-P)." title="TNF-alpha in Mouse Spleen Tissue." data-caption="TNF-alpha was detected in immersion fixed paraffin-embedded sections of mouse spleen tissue using Goat Anti-Human/Mouse TNF-alpha Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-410-NA) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to lymphocytes. Staining was performed using our IHC Staining with VisUCyte HRP Polymer Detection Reagents." data-badges="" data-application="Immunohistochemistry" data-header="Human/Mouse TNF-alpha Antibody, Catalog # AF-410-NA" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AF-410-NA_Block_Neutralize_8706.jpg" data-alt="Cytotoxicity Induced by TNF-alpha and Neutralization by Mouse TNF-alpha Antibody." title="Cytotoxicity Induced by TNF-alpha and Neutralization by Mouse TNF-alpha Antibody." data-caption="Recombinant Mouse TNF-a (410-MT) induces cytotoxicity in the the L-929 mouse fibroblast cell line in a dose-dependent manner (orange line). Cytotoxicity elicited by Recombinant Mouse TNF-a (0.1 ng/mL) is neutralized (green line) by increasing concentrations of Human/Mouse TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-410-NA). The ND<SUB>50</SUB> is typically 1.5-10 ng/mL in the presence of the metabolic inhibitor actinomycin D." data-badges="" data-application="Neutralization" data-header="Human/Mouse TNF-alpha Antibody, Catalog # AF-410-NA" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/antibody/af-410-na_mouse-tnf-alpha-affinity-purified-polyclonal-ab-immunohistochemistry-3152023132230.jpg" data-alt="" title="Detection of TNF-alpha in Human Spleen." data-caption="TNF-alpha was detected in immersion fixed paraffin-embedded sections of Human Spleen using Goat Anti-Human/Mouse TNF-alpha Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-410-NA) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in lymphocytes. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." data-badges="" data-application="Immunohistochemistry" data-header="Human/Mouse TNF-alpha Antibody, Catalog # AF-410-NA" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/af-410-na_mouse-tnf-alpha-affinity-purified-polyclonal-ab-41202410331929.jpg" data-alt="Detection of Mouse TNF-alpha by Western Blot" title="Detection of Mouse TNF-alpha by Western Blot" data-caption="WNT-5A induces a proinflammatory transformation in mouse microglia. (A, B) iNOS, COX-2 and TNF alpha were detected by immunoblotting in lysates from mouse primary microglia after WNT-5A stimulation (ctrl, 300 ng/ml, 6 hours). (B’) shows TNF alpha levels in the supernatant of primary microglia under ctrl conditions and upon WNT-5A stimulation (ctrl, 300 ng/ml, 24 hours; n = 4). At least three experiments are summarized in the bar graphs. Data are normalized to ctrl. Error bars give s.e.m. (C) Microglial proliferation was assessed by an MTT assay monitoring mitochondrial activity, which is proportional to cell number [see Additional file 1: Figure S5]. Stimulation with WNT-5A (300 ng/ml, 24 hours) increased MTT, which was blocked by PTX (100 ng/ml, overnight) or the MEK1/2 (10 μM) inhibitor, SL327. (D). Experiments were done in triplicate and data from three independent experiments are shown. *, P " data-badges="" data-application="Western Blot" data-header="Human/Mouse TNF-alpha Antibody, Catalog # AF-410-NA" data-width="250" data-height="250" class="none"></i> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-AF-410-NA" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="AF-410-NA"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-AF-410-NA" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF-410-NA"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF-410-NA </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF-410-SP"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF-410-SP </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-AF-410-NA-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=AF-410-NA" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="BAF210" data-name="Human TNF-alpha Biotinylated Antibody" data-position="4"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/human-tnf-alpha-biotinylated-antibody_baf210" title="Human TNF-alpha Biotinylated Antibody"> <h4>Human TNF-alpha Biotinylated Antibody <span class="rounded align-middle p-1 badge best-seller" title="Best Seller">Best Seller</span> </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/human-tnf-alpha-biotinylated-antibody_baf210" title="Human TNF-alpha Biotinylated Antibody"> BAF210 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/human-tnf-alpha-biotinylated-antibody_baf210#reviews" class="searchImage_star5"> (1) </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/human-tnf-alpha-biotinylated-antibody_baf210#citations"><span class="icon-icon-product-citations"></span>Citations (69)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/human-tnf-alpha-biotinylated-antibody_baf210#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (1)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB, ICC </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Human </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-4" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-4"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Human </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB, ICC </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="baf210"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/antibody/TNFalpha_BAF210_Immunocytochemistry__Immunofluorescence_19771.jpg data-srcset=https://resources.bio-techne.com/images/products/antibody/TNFalpha_BAF210_Immunocytochemistry__Immunofluorescence_19771.jpg alt="TNF-a antibody in Human PBMCs by Immunocytochemistry (ICC)." title="TNF‑ alpha in Human PBMCs." data-caption="TNF-a was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) using Goat Anti-Human TNF-a Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF210) at 5 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Streptavidin (red; Catalog # NL999) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells." data-badges="" data-application="Immunocytochemistry" data-header="Human TNF-alpha Biotinylated Antibody, Catalog # BAF210" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-BAF210" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="BAF210"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-BAF210" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="BAF210"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> BAF210 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-BAF210-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=BAF210" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="AF-210-NA" data-name="Human TNF-alpha Antibody" data-position="5"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/human-tnf-alpha-antibody_af-210-na" title="Human TNF-alpha Antibody"> <h4>Human TNF-alpha Antibody <span class="rounded align-middle p-1 badge best-seller" title="Best Seller">Best Seller</span> </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/human-tnf-alpha-antibody_af-210-na" title="Human TNF-alpha Antibody"> AF-210-NA </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/human-tnf-alpha-antibody_af-210-na#reviews" class="searchImage_star5"> (3) </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/human-tnf-alpha-antibody_af-210-na#citations"><span class="icon-icon-product-citations"></span>Citations (60)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/human-tnf-alpha-antibody_af-210-na#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (3)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB, ICC, Neut </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Human </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-5" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-5"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Human </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB, ICC, Neut </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="af-210-na"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AF-210-NA_Block_Neutralize_8647.jpg data-srcset=https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AF-210-NA_Block_Neutralize_8647.jpg alt="Cytotoxicity Induced by TNF‑ alpha and Neutralization by Human TNF-alpha Antibody." title="Cytotoxicity Induced by TNF‑ alpha and Neutralization by Human TNF-alpha Antibody." data-caption="Recombinant Human TNF-a (Catalog # 210-TA) induces cytotoxicity in the L-929 mouse fibroblast cell line in a dose-dependent manner (orange line). Cytotoxicity elicited by Recombinant Human TNF-a (1.5 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-210-NA). The ND<SUB>50</SUB> is typically 0.01-0.06 µg/mL." data-badges="" data-application="Neutralization" data-header="Human TNF-alpha Antibody, Catalog # AF-210-NA" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> <span class="image-count-text align-middle">(3)</span> </div> </div> </div> <i data-src="https://resources.bio-techne.com/images/products/antibody/TNFalpha_AF210NA_Immunocytochemistry__Immunofluorescence_19770.jpg" data-alt="TNF-a antibody in Human PBMCs by Immunocytochemistry (ICC)." title="TNF‑ alpha in Human PBMCs." data-caption="TNF-a was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) using Goat Anti-Human TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-210-NA) at 5 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells." data-badges="" data-application="Immunocytochemistry" data-header="Human TNF-alpha Antibody, Catalog # AF-210-NA" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/af-210-na_human-tnf-alpha-affinity-purified-polyclonal-ab-41202410482433.jpg" data-alt="Detection of Human TNF-alpha by Functional" title="Detection of Human TNF-alpha by Functional" data-caption="TPM1 and TPM4 expression in response to TNF alpha.High molecular weight tropomyosin isoform expression in THP1 cells in response to elevated concentrations of TNF alpha. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/27649540), licensed under a CC-BY license. Not internally tested by R&D Systems." data-badges="" data-application="Functional" data-header="Human TNF-alpha Antibody, Catalog # AF-210-NA" data-width="250" data-height="250" class="none"></i> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-AF-210-NA" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="AF-210-NA"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-AF-210-NA" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF-210-NA"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF-210-NA </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF-210-SP"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF-210-SP </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-AF-210-NA-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=AF-210-NA" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="AF-510-NA" data-name="Rat TNF-alpha Antibody" data-position="6"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/rat-tnf-alpha-antibody_af-510-na" title="Rat TNF-alpha Antibody"> <h4>Rat TNF-alpha Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/rat-tnf-alpha-antibody_af-510-na" title="Rat TNF-alpha Antibody"> AF-510-NA </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/rat-tnf-alpha-antibody_af-510-na#citations"><span class="icon-icon-product-citations"></span>Citations (67)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/rat-tnf-alpha-antibody_af-510-na#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (4)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB, ICC, Neut </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Rat </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-6" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-6"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Rat </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB, ICC, Neut </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="af-510-na"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AF-510-NA_Block_Neutralize_8735.jpg data-srcset=https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AF-510-NA_Block_Neutralize_8735.jpg alt="Cytotoxicity Induced by TNF-alpha and Neutralization by Rat TNF-alpha Antibody." title="Cytotoxicity Induced by TNF-alpha and Neutralization by Rat TNF-alpha Antibody." data-caption="Recombinant Rat TNF-a (Catalog # 510-RT) induces cytotoxicity in the the L-929 mouse fibroblast cell line in a dose-dependent manner (orange line), as measured by Resazurin. Cytotoxicity elicited by Recombinant Rat TNF-a (0.25 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Rat TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-510-NA). The ND<SUB>50</SUB> is typically 0.15-0.75 µg/mL in the presence of the metabolic inhibitor actinomycin D (1 µg/mL)." data-badges="" data-application="Neutralization" data-header="Rat TNF-alpha Antibody, Catalog # AF-510-NA" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> <span class="image-count-text align-middle">(4)</span> </div> </div> </div> <i data-src="https://resources.bio-techne.com/images/products/antibody/TNFalpha_AF510NA_Immunocytochemistry__Immunofluorescence_17447.jpg" data-alt="TNF-a antibody in Rat Splenocytes by Immunocytochemistry (ICC)." title="TNF‑ alpha in Rat Splenocytes." data-caption="TNF-a was detected in immersion fixed rat splenocytes using Goat Anti-Rat TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-510-NA) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasmic. View our protocol for Fluorescent ICC Staining of Non-adherent Cells." data-badges="" data-application="Immunocytochemistry" data-header="Rat TNF-alpha Antibody, Catalog # AF-510-NA" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/af-510-na_rat-tnf-alpha-affinity-purified-polyclonal-ab-8220249501924.jpg" data-alt="Detection of Porcine TNF-alpha by Immunocytochemistry/ Immunofluorescence" title="Detection of Porcine TNF-alpha by Immunocytochemistry/ Immunofluorescence" data-caption="Astrocytes activity and GFAP/TNF-alpha double staining in the DG area.Astrocyte activity was measure with GFAP immunofluorescence. Representative photomicrographs show control and LPS-injected rats at different time points up to day 30. (A) Densitometry of GFAP fluorescence intensity was up-regulated from day 1 to day 7. Following LPS injection, astrocytes showed changes in morphology, which was recognized by decreased ramification and hypertrophy of the soma. (B) Double fluorescence staining of GFAP and TNF-alpha in hippocampal astrocytes. The ratio of TNF-alpha positive astrocytes in total astrocytes (GFAP-positive cells) was significantly increased from day 1 and peaking on day 7. Pictures show DG area, data are expressed as mean ± standard error of the mean (n = 4) and compared by 1-way analysis of variance followed with Boferroni post hoc analysis, **p" data-badges="" data-application="Immunocytochemistry/ Immunofluorescence" data-header="Rat TNF-alpha Antibody, Catalog # AF-510-NA" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/af-510-na_rat-tnf-alpha-affinity-purified-polyclonal-ab-44202415425032.jpg" data-alt="Detection of Rat TNF-alpha by Immunocytochemistry/ Immunofluorescence" title="Detection of Rat TNF-alpha by Immunocytochemistry/ Immunofluorescence" data-caption="Astrocytes activity and GFAP/TNF-alpha double staining in the DG area.Astrocyte activity was measure with GFAP immunofluorescence. Representative photomicrographs show control and LPS-injected rats at different time points up to day 30. (A) Densitometry of GFAP fluorescence intensity was up-regulated from day 1 to day 7. Following LPS injection, astrocytes showed changes in morphology, which was recognized by decreased ramification and hypertrophy of the soma. (B) Double fluorescence staining of GFAP and TNF-alpha in hippocampal astrocytes. The ratio of TNF-alpha positive astrocytes in total astrocytes (GFAP-positive cells) was significantly increased from day 1 and peaking on day 7. Pictures show DG area, data are expressed as mean ± standard error of the mean (n = 4) and compared by 1-way analysis of variance followed with Boferroni post hoc analysis, **p" data-badges="" data-application="Immunocytochemistry/ Immunofluorescence" data-header="Rat TNF-alpha Antibody, Catalog # AF-510-NA" data-width="250" data-height="250" class="none"></i> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-AF-510-NA" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="AF-510-NA"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-AF-510-NA" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF-510-NA"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF-510-NA </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF-510-SP"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF-510-SP </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-AF-510-NA-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=AF-510-NA" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="BAF410" data-name="Mouse TNF-alpha Biotinylated Antibody" data-position="10"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/mouse-tnf-alpha-biotinylated-antibody_baf410" title="Mouse TNF-alpha Biotinylated Antibody"> <h4>Mouse TNF-alpha Biotinylated Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/mouse-tnf-alpha-biotinylated-antibody_baf410" title="Mouse TNF-alpha Biotinylated Antibody"> BAF410 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/mouse-tnf-alpha-biotinylated-antibody_baf410#reviews" class="searchImage_star5"> (2) </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/mouse-tnf-alpha-biotinylated-antibody_baf410#citations"><span class="icon-icon-product-citations"></span>Citations (41)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/mouse-tnf-alpha-biotinylated-antibody_baf410#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Mouse </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-10" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-10"> <div class="row"> <div class="search_result_description col-xs-12 col-sm-12"> </div> </div> <div class="row"> <div class="search_result_product_details col-xs-12 col-sm-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Mouse </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="baf410"></div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-BAF410" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="BAF410"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-BAF410" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="BAF410"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> BAF410 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-BAF410-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=BAF410" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="AB-410-NA" data-name="Mouse TNF-alpha Antibody" data-position="14"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/mouse-tnf-alpha-antibody_ab-410-na" title="Mouse TNF-alpha Antibody"> <h4>Mouse TNF-alpha Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/mouse-tnf-alpha-antibody_ab-410-na" title="Mouse TNF-alpha Antibody"> AB-410-NA </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/mouse-tnf-alpha-antibody_ab-410-na#citations"><span class="icon-icon-product-citations"></span>Citations (27)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/mouse-tnf-alpha-antibody_ab-410-na#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (3)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB, Neut </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Mouse </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-14" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-14"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Mouse </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB, Neut </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="ab-410-na"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AB-410-NA_Block_Neutralize_8621.jpg data-srcset=https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AB-410-NA_Block_Neutralize_8621.jpg alt="Cytotoxicity Induced by TNF-alpha and Neutralization by Mouse TNF-alpha Antibody." title="Cytotoxicity Induced by TNF-alpha and Neutralization by Mouse TNF-alpha Antibody." data-caption="Recombinant Mouse TNF-a (Catalog # 410-MT) induces cytotoxicity in the the L-929 mouse fibroblast cell line in a dose-dependent manner (orange line), as measured by crystal violet staining. Cytotoxicity elicited by Recombinant Mouse TNF-a (0.25 ng/mL) is neutralized (green line) by increasing concentrations of Mouse TNF-a Polyclonal Antibody (Catalog # AB-410-NA). The ND<SUB>50</SUB> is typically 0.2-0.6 µg/mL in the presence of the metabolic inhibitor actinomycin D (1 µg/mL)." data-badges="" data-application="Neutralization" data-header="Mouse TNF-alpha Antibody, Catalog # AB-410-NA" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> <span class="image-count-text align-middle">(3)</span> </div> </div> </div> <i data-src="https://resources.bio-techne.com/images/products/ab-410-na_mouse-tnf-alpha-polyclonal-ab-22820241721170.jpg" data-alt="Detection of Mouse Mouse TNF-alpha Antibody by Western Blot" title="Detection of Mouse Mouse TNF-alpha Antibody by Western Blot" data-caption="Effect of a TNF-alpha -neutralizing antibody on LPS-induced perturbation of muscle differentiation.(A) C2C12 myoblasts were cultured for 48 h in DM alone, LPS (1 μg/mL), or LPS (1 μg/mL) plus TNF-alpha -neutralizing antibody (5 μg/mL). A representative western blot probed with antibodies to myogenin, MyoD, or beta-tubulin (internal standard) is shown. (B and C) Quantification of the data presented in (A). Data are the mean ± SEM of 7–15 independent experiments. (D) C2C12 myoblasts were cultured for 144 h as described in (A). A representative western blot probed with antibodies to MyHC II, myostatin, or beta-tubulin (internal standard) is shown. (E and F) Quantification of the data presented in (D). Data are the mean ± SEM of 5–21 independent experiments. (G) Cells were treated as described in (A), and NF-kappa B activity was analyzed by ELISA. Data are the mean ± SEM of 7 independent experiments performed in duplicate. ***p < 0.001, **p < 0.01, *p < 0.05, ###p < 0.001, ##p < 0.01, #p < 0.05 by one-way ANOVA followed by Tukey’s honest significant difference test. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28742154), licensed under a CC-BY license. Not internally tested by R&D Systems." data-badges="" data-application="Western Blot" data-header="Mouse TNF-alpha Antibody, Catalog # AB-410-NA" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/ab-410-na_mouse-tnf-alpha-polyclonal-ab-2282024173313.jpg" data-alt="Detection of Mouse Mouse TNF-alpha Antibody by Western Blot" title="Detection of Mouse Mouse TNF-alpha Antibody by Western Blot" data-caption="Effect of a TNF-alpha -neutralizing antibody on LPS-induced perturbation of muscle differentiation.(A) C2C12 myoblasts were cultured for 48 h in DM alone, LPS (1 μg/mL), or LPS (1 μg/mL) plus TNF-alpha -neutralizing antibody (5 μg/mL). A representative western blot probed with antibodies to myogenin, MyoD, or beta-tubulin (internal standard) is shown. (B and C) Quantification of the data presented in (A). Data are the mean ± SEM of 7–15 independent experiments. (D) C2C12 myoblasts were cultured for 144 h as described in (A). A representative western blot probed with antibodies to MyHC II, myostatin, or beta-tubulin (internal standard) is shown. (E and F) Quantification of the data presented in (D). Data are the mean ± SEM of 5–21 independent experiments. (G) Cells were treated as described in (A), and NF-kappa B activity was analyzed by ELISA. Data are the mean ± SEM of 7 independent experiments performed in duplicate. ***p < 0.001, **p < 0.01, *p < 0.05, ###p < 0.001, ##p < 0.01, #p < 0.05 by one-way ANOVA followed by Tukey’s honest significant difference test. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28742154), licensed under a CC-BY license. Not internally tested by R&D Systems." data-badges="" data-application="Western Blot" data-header="Mouse TNF-alpha Antibody, Catalog # AB-410-NA" data-width="250" data-height="250" class="none"></i> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-AB-410-NA" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="AB-410-NA"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-AB-410-NA" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AB-410-NA"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AB-410-NA </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-AB-410-NA-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=AB-410-NA" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="AF690" data-name="Porcine TNF-alpha Antibody" data-position="17"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/porcine-tnf-alpha-antibody_af690" title="Porcine TNF-alpha Antibody"> <h4>Porcine TNF-alpha Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/porcine-tnf-alpha-antibody_af690" title="Porcine TNF-alpha Antibody"> AF690 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/porcine-tnf-alpha-antibody_af690#citations"><span class="icon-icon-product-citations"></span>Citations (6)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/porcine-tnf-alpha-antibody_af690#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (4)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB, ICC, Neut </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Porcine </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-17" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-17"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Porcine </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB, ICC, Neut </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="af690"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AF690_Block_Neutralize_8949.jpg data-srcset=https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AF690_Block_Neutralize_8949.jpg alt="Cytotoxicity Induced by TNF-alpha and Neutralization by Porcine TNF-alpha Antibody." title="Cytotoxicity Induced by TNF-alpha and Neutralization by Porcine TNF-alpha Antibody." data-caption="Recombinant Porcine TNF-a (Catalog # 690-PT) induces cytotoxicity in the the PK-15 porcine kidney epithelial cell line in a dose-dependent manner (orange line), as measured by crystal violet staining. Cytotoxicity elicited by Recombinant Porcine TNF-a (0.05 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Porcine TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF690). The ND<SUB>50</SUB> is typically 0.2-0.8 µg/mL in the presence of the metabolic inhibitor actinomycin D (1 µg/mL)." data-badges="" data-application="Neutralization" data-header="Porcine TNF-alpha Antibody, Catalog # AF690" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> <span class="image-count-text align-middle">(4)</span> </div> </div> </div> <i data-src="https://resources.bio-techne.com/images/products/antibody/TNFalpha_AF690_Immunocytochemistry__Immunofluorescence_19172.jpg" data-alt="TNF-a antibody in Porcine PBMCs by Immunocytochemistry (ICC)." title="TNF‑ alpha in Porcine PBMCs." data-caption="TNF-a was detected in immersion fixed porcine peripheral blood mononuclear cells (PBMCs) treated with calcium ionomycin and PMA using Goat Anti-Porcine TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF690) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells." data-badges="<span class="biological-validation"></span>" data-application="Immunocytochemistry" data-header="Porcine TNF-alpha Antibody, Catalog # AF690" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/af690_porcine-tnf-alpha-affinity-purified-polyclonal-ab-82202410063.jpg" data-alt="Detection of Porcine TNF-alpha by Western Blot" title="Detection of Porcine TNF-alpha by Western Blot" data-caption="Inflammatory response in PAMs induced by PRRSV 5′UTR RNA and LPS. A, B PAMs were transfected with different doses of 5′UTR RNA (1, 2, and 4 μg/well) along with 1 μg/mL LPS. qRT-PCR and Western blot results showed that compared with PAMs in other groups, PAMs in the 4 μg 5′UTR RNA and 1 μg/mL LPS co-stimulation group produced higher levels of IL-1 beta (p < 0.05). C After co-stimulation, the relative expression level of IL-1 beta mRNA obtained was similar at the 12 and 24 h time-points. D 5′UTR RNA and LPS co-stimulation induced IL-1 beta expression in cells and supernatants. E, F 5′UTR RNA and LPS co-stimulation induced increased levels of IL-6, IL-8 and TNF-alpha mRNA and protein. Expression was normalized to that of GAPDH. Different letters (a, b, c, d, and e) on data indicate significant differences between groups (p < 0.05). Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/31300043), licensed under a CC-BY license. Not internally tested by R&D Systems." data-badges="" data-application="Western Blot" data-header="Porcine TNF-alpha Antibody, Catalog # AF690" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/af690_porcine-tnf-alpha-affinity-purified-polyclonal-ab-44202415425075.jpg" data-alt="Detection of Porcine TNF-alpha by Western Blot" title="Detection of Porcine TNF-alpha by Western Blot" data-caption="Inflammatory response in PAMs induced by PRRSV 5′UTR RNA and LPS. A, B PAMs were transfected with different doses of 5′UTR RNA (1, 2, and 4 μg/well) along with 1 μg/mL LPS. qRT-PCR and Western blot results showed that compared with PAMs in other groups, PAMs in the 4 μg 5′UTR RNA and 1 μg/mL LPS co-stimulation group produced higher levels of IL-1 beta (p " data-badges="" data-application="Western Blot" data-header="Porcine TNF-alpha Antibody, Catalog # AF690" data-width="250" data-height="250" class="none"></i> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-AF690" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="AF690"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-AF690" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF690"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF690 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF690-SP"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF690-SP </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-AF690-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=AF690" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="AB-210-NA" data-name="Human TNF-alpha Antibody" data-position="18"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/human-tnf-alpha-antibody_ab-210-na" title="Human TNF-alpha Antibody"> <h4>Human TNF-alpha Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/human-tnf-alpha-antibody_ab-210-na" title="Human TNF-alpha Antibody"> AB-210-NA </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/human-tnf-alpha-antibody_ab-210-na#citations"><span class="icon-icon-product-citations"></span>Citations (20)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/human-tnf-alpha-antibody_ab-210-na#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (1)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB, Neut </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Human </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-18" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-18"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Human </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB, Neut </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="ab-210-na"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AB-210-NA_Block_Neutralize_8568.jpg data-srcset=https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AB-210-NA_Block_Neutralize_8568.jpg alt="Cytotoxicity Induced by TNF-alpha and Neutralization by Human TNF-alpha Antibody." title="Cytotoxicity Induced by TNF-alpha and Neutralization by Human TNF-alpha Antibody." data-caption="Recombinant Human TNF-a (Catalog # 210-TA) induces cytotoxicity in the the L-929 mouse fibroblast cell line in a dose-dependent manner (orange line). Cytotoxicity elicited by Recombinant Human TNF-a (0.25 ng/mL) is neutralized (green line) by increasing concentrations of Human TNF-a Polyclonal Antibody (Catalog # AB-210-NA). The ND<SUB>50</SUB> is typically 0.05-0.25 µg/mL in the presence of the metabolic inhibitor actinomycin D (1 µg/mL)." data-badges="" data-application="Neutralization" data-header="Human TNF-alpha Antibody, Catalog # AB-210-NA" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-AB-210-NA" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="AB-210-NA"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-AB-210-NA" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AB-210-NA"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AB-210-NA </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-AB-210-NA-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=AB-210-NA" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="BAF690" data-name="Porcine TNF-alpha Biotinylated Antibody" data-position="8"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/porcine-tnf-alpha-biotinylated-antibody_baf690" title="Porcine TNF-alpha Biotinylated Antibody"> <h4>Porcine TNF-alpha Biotinylated Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/porcine-tnf-alpha-biotinylated-antibody_baf690" title="Porcine TNF-alpha Biotinylated Antibody"> BAF690 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/porcine-tnf-alpha-biotinylated-antibody_baf690#citations"><span class="icon-icon-product-citations"></span>Citations (5)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/porcine-tnf-alpha-biotinylated-antibody_baf690#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Porcine </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-8" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-8"> <div class="row"> <div class="search_result_description col-xs-12 col-sm-12"> </div> </div> <div class="row"> <div class="search_result_product_details col-xs-12 col-sm-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Porcine </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="baf690"></div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-BAF690" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="BAF690"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-BAF690" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="BAF690"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> BAF690 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-BAF690-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=BAF690" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="BAF510" data-name="Rat TNF-alpha Biotinylated Antibody" data-position="9"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/rat-tnf-alpha-biotinylated-antibody_baf510" title="Rat TNF-alpha Biotinylated Antibody"> <h4>Rat TNF-alpha Biotinylated Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/rat-tnf-alpha-biotinylated-antibody_baf510" title="Rat TNF-alpha Biotinylated Antibody"> BAF510 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/rat-tnf-alpha-biotinylated-antibody_baf510#reviews" class="searchImage_star5"> (1) </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/rat-tnf-alpha-biotinylated-antibody_baf510#citations"><span class="icon-icon-product-citations"></span>Citations (6)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/rat-tnf-alpha-biotinylated-antibody_baf510#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Rat </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-9" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-9"> <div class="row"> <div class="search_result_description col-xs-12 col-sm-12"> </div> </div> <div class="row"> <div class="search_result_product_details col-xs-12 col-sm-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Rat </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="baf510"></div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-BAF510" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="BAF510"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-BAF510" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="BAF510"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> BAF510 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-BAF510-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=BAF510" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="AF1814" data-name="Equine TNF-alpha Antibody" data-position="10"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/equine-tnf-alpha-antibody_af1814" title="Equine TNF-alpha Antibody"> <h4>Equine TNF-alpha Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/equine-tnf-alpha-antibody_af1814" title="Equine TNF-alpha Antibody"> AF1814 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/equine-tnf-alpha-antibody_af1814#citations"><span class="icon-icon-product-citations"></span>Citations (1)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/equine-tnf-alpha-antibody_af1814#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (2)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB, ICC, Neut </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Equine </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-10" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-10"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Equine </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB, ICC, Neut </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="af1814"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/antibody/TNFalpha_AF1814_Immunocytochemistry__Immunofluorescence_19124.jpg data-srcset=https://resources.bio-techne.com/images/products/antibody/TNFalpha_AF1814_Immunocytochemistry__Immunofluorescence_19124.jpg alt="TNF-a antibody in Equine PBMCs by Immunocytochemistry (ICC)." title="TNF‑ alpha in Equine PBMCs." data-caption="TNF-a was detected in immersion fixed equine peripheral blood mononuclear cells (PBMCs) using Goat Anti-Equine TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1814) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells." data-badges="" data-application="Immunocytochemistry" data-header="Equine TNF-alpha Antibody, Catalog # AF1814" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> <span class="image-count-text align-middle">(2)</span> </div> </div> </div> <i data-src="https://resources.bio-techne.com/images/products/antibody/TNFalpha_AF1814_Block_Neutralize_15938.jpg" data-alt="Cytotoxicity Induced by TNF‑ alpha and Neutralization by Equine TNF‑ alpha Antibody." title="Cytotoxicity Induced by TNF‑ alpha and Neutralization by Equine TNF‑ alpha Antibody." data-caption="Recombinant Equine TNF-a (Catalog # 1814-ET) induces cytotoxicity in the the L-929 mouse fibroblast cell line in a dose-dependent manner (orange line), as measured by Resazurin (Catalog # AR002). Cytotoxicity elicited by Recombinant Equine TNF-a (1 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Equine TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1814). The ND<SUB>50</SUB> is typically 0.01-0.03 µg/mL in the presence of the metabolic inhibitor actinomycin D (1 µg/mL)." data-badges="" data-application="Neutralization" data-header="Equine TNF-alpha Antibody, Catalog # AF1814" data-width="250" data-height="250" class="none"></i> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-AF1814" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="AF1814"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-AF1814" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF1814"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF1814 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF1814-SP"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF1814-SP </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-AF1814-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=AF1814" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="AF2279" data-name="Bovine TNF-alpha Antibody" data-position="11"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/bovine-tnf-alpha-antibody_af2279" title="Bovine TNF-alpha Antibody"> <h4>Bovine TNF-alpha Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/bovine-tnf-alpha-antibody_af2279" title="Bovine TNF-alpha Antibody"> AF2279 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/bovine-tnf-alpha-antibody_af2279#reviews" class="searchImage_star5"> (1) </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/bovine-tnf-alpha-antibody_af2279#citations"><span class="icon-icon-product-citations"></span>Citations (1)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/bovine-tnf-alpha-antibody_af2279#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (1)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB, ICC </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Bovine </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-11" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-11"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Bovine </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB, ICC </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="af2279"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/antibody/TNFalpha_AF2279_Immunocytochemistry__Immunofluorescence_17425.jpg data-srcset=https://resources.bio-techne.com/images/products/antibody/TNFalpha_AF2279_Immunocytochemistry__Immunofluorescence_17425.jpg alt="TNF-a antibody in Bovine PBMCs by Immunocytochemistry (ICC)." title="TNF‑ alpha in Bovine PBMCs." data-caption="TNF-a was detected in immersion fixed bovine peripheral blood mononuclear cells (PBMCs) using Goat Anti-Bovine TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2279) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells." data-badges="" data-application="Immunocytochemistry" data-header="Bovine TNF-alpha Antibody, Catalog # AF2279" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-AF2279" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="AF2279"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-AF2279" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF2279"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF2279 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF2279-SP"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF2279-SP </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-AF2279-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=AF2279" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="AF1507" data-name="Canine TNF-alpha Antibody" data-position="12"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/canine-tnf-alpha-antibody_af1507" title="Canine TNF-alpha Antibody"> <h4>Canine TNF-alpha Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/canine-tnf-alpha-antibody_af1507" title="Canine TNF-alpha Antibody"> AF1507 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/canine-tnf-alpha-antibody_af1507#citations"><span class="icon-icon-product-citations"></span>Citations (1)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/canine-tnf-alpha-antibody_af1507#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (2)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB, ICC, Neut </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Canine </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-12" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-12"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Canine </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB, ICC, Neut </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="af1507"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/antibody/TNFalpha_AF1507_Immunocytochemistry__Immunofluorescence_19408.jpg data-srcset=https://resources.bio-techne.com/images/products/antibody/TNFalpha_AF1507_Immunocytochemistry__Immunofluorescence_19408.jpg alt="TNF-a antibody in Canine PBMCs by Immunocytochemistry (ICC)." title="TNF‑ alpha in Canine PBMCs." data-caption="TNF-a was detected in immersion fixed canine peripheral blood mononuclear cells (PBMCs) stimulated with PMA and calcium ionomycin using Goat Anti-Canine TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1507) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells." data-badges="" data-application="Immunocytochemistry" data-header="Canine TNF-alpha Antibody, Catalog # AF1507" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> <span class="image-count-text align-middle">(2)</span> </div> </div> </div> <i data-src="https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AF1507_Block_Neutralize_8782.jpg" data-alt="Cytotoxicity Induced by TNF-alpha and Neutralization by Canine TNF-alpha Antibody." title="Cytotoxicity Induced by TNF-alpha and Neutralization by Canine TNF-alpha Antibody." data-caption="Recombinant Canine TNF-a (1507-CT) induces cytotoxicity in the the L-929 mouse fibroblast cell line in a dose-dependent manner (orange line), as measured by crystal violet staining. Cytotoxicity elicited by Recombinant Canine TNF-a (100 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Canine TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1507). The ND<SUB>50</SUB> is typically 0.4-1.6 µg/mL in the presence of the metabolic inhibitor actinomycin D (1 µg/mL)." data-badges="" data-application="Neutralization" data-header="Canine TNF-alpha Antibody, Catalog # AF1507" data-width="250" data-height="250" class="none"></i> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-AF1507" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="AF1507"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-AF1507" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF1507"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF1507 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF1507-SP"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF1507-SP </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-AF1507-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=AF1507" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="BAF2279" data-name="Bovine TNF-alpha Biotinylated Antibody" data-position="15"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/bovine-tnf-alpha-biotinylated-antibody_baf2279" title="Bovine TNF-alpha Biotinylated Antibody"> <h4>Bovine TNF-alpha Biotinylated Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/bovine-tnf-alpha-biotinylated-antibody_baf2279" title="Bovine TNF-alpha Biotinylated Antibody"> BAF2279 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/bovine-tnf-alpha-biotinylated-antibody_baf2279#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (1)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB, ICC </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Bovine </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-15" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-15"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Bovine </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB, ICC </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="baf2279"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/antibody/TNFalpha_BAF2279_Immunocytochemistry__Immunofluorescence_17426.jpg data-srcset=https://resources.bio-techne.com/images/products/antibody/TNFalpha_BAF2279_Immunocytochemistry__Immunofluorescence_17426.jpg alt="TNF-a antibody in Bovine PBMCs by Immunocytochemistry (ICC)." title="TNF‑ alpha in Bovine PBMCs." data-caption="TNF-a was detected in immersion fixed bovine peripheral blood mononuclear cells (PBMCs) using Goat Anti-Bovine TNF-a Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF2279) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Streptavidin (red; Catalog # NL999) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells." data-badges="" data-application="Immunocytochemistry" data-header="Bovine TNF-alpha Biotinylated Antibody, Catalog # BAF2279" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-BAF2279" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="BAF2279"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-BAF2279" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="BAF2279"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> BAF2279 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-BAF2279-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=BAF2279" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="BAF1507" data-name="Canine TNF-alpha Biotinylated Antibody" data-position="16"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/canine-tnf-alpha-biotinylated-antibody_baf1507" title="Canine TNF-alpha Biotinylated Antibody"> <h4>Canine TNF-alpha Biotinylated Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/canine-tnf-alpha-biotinylated-antibody_baf1507" title="Canine TNF-alpha Biotinylated Antibody"> BAF1507 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/canine-tnf-alpha-biotinylated-antibody_baf1507#citations"><span class="icon-icon-product-citations"></span>Citations (1)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/canine-tnf-alpha-biotinylated-antibody_baf1507#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (1)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB, ICC </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Canine </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-16" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-16"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Canine </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB, ICC </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="baf1507"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/antibody/TNFalpha_BAF1507_Immunocytochemistry__Immunofluorescence_19411.jpg data-srcset=https://resources.bio-techne.com/images/products/antibody/TNFalpha_BAF1507_Immunocytochemistry__Immunofluorescence_19411.jpg alt="TNF-a antibody in Canine PBMCs by Immunocytochemistry (ICC)." title="TNF‑ alpha in Canine PBMCs." data-caption="TNF-a was detected in immersion fixed canine peripheral blood mononuclear cells (PBMCs) stimulated with PMA and calcium ionomycin using Goat Anti-Canine TNF-a Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF1507) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Streptavidin (red; Catalog # NL999) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells." data-badges="" data-application="Immunocytochemistry" data-header="Canine TNF-alpha Biotinylated Antibody, Catalog # BAF1507" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-BAF1507" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="BAF1507"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-BAF1507" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="BAF1507"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> BAF1507 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-BAF1507-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=BAF1507" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="BAF1011" data-name="Cotton Rat TNF-alpha Biotinylated Antibody" data-position="15"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/cotton-rat-tnf-alpha-biotinylated-antibody_baf1011" title="Cotton Rat TNF-alpha Biotinylated Antibody"> <h4>Cotton Rat TNF-alpha Biotinylated Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/cotton-rat-tnf-alpha-biotinylated-antibody_baf1011" title="Cotton Rat TNF-alpha Biotinylated Antibody"> BAF1011 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/cotton-rat-tnf-alpha-biotinylated-antibody_baf1011#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Cotton Rat </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-15" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-15"> <div class="row"> <div class="search_result_description col-xs-12 col-sm-12"> </div> </div> <div class="row"> <div class="search_result_product_details col-xs-12 col-sm-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Cotton Rat </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="baf1011"></div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-BAF1011" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="BAF1011"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-BAF1011" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="BAF1011"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> BAF1011 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-BAF1011-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=BAF1011" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="BAF1070" data-name="Rhesus Macaque TNF‑ alpha Biotinylated&nbsp;Antibody" data-position="16"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/rhesus-macaque-tnf-alpha-biotinylated-antibody_baf1070" title="Rhesus Macaque TNF‑ alpha Biotinylated&nbsp;Antibody"> <h4>Rhesus Macaque TNF‑ alpha Biotinylated Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/rhesus-macaque-tnf-alpha-biotinylated-antibody_baf1070" title="Rhesus Macaque TNF‑ alpha Biotinylated&nbsp;Antibody"> BAF1070 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/rhesus-macaque-tnf-alpha-biotinylated-antibody_baf1070#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Rhesus Macaque </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-16" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-16"> <div class="row"> <div class="search_result_description col-xs-12 col-sm-12"> </div> </div> <div class="row"> <div class="search_result_product_details col-xs-12 col-sm-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Rhesus Macaque </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="baf1070"></div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-BAF1070" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="BAF1070"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-BAF1070" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="BAF1070"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> BAF1070 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-BAF1070-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=BAF1070" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="AF1070" data-name="Rhesus Macaque TNF-alpha Antibody" data-position="17"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/rhesus-macaque-tnf-alpha-antibody_af1070" title="Rhesus Macaque TNF-alpha Antibody"> <h4>Rhesus Macaque TNF-alpha Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/rhesus-macaque-tnf-alpha-antibody_af1070" title="Rhesus Macaque TNF-alpha Antibody"> AF1070 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/rhesus-macaque-tnf-alpha-antibody_af1070#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Rhesus Macaque </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-17" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-17"> <div class="row"> <div class="search_result_description col-xs-12 col-sm-12"> </div> </div> <div class="row"> <div class="search_result_product_details col-xs-12 col-sm-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Rhesus Macaque </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="af1070"></div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-AF1070" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="AF1070"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-AF1070" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF1070"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF1070 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF1070-SP"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF1070-SP </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-AF1070-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=AF1070" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Primary Antibodies" data-id="AF1011" data-name="Cotton Rat TNF-alpha Antibody" data-position="18"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/cotton-rat-tnf-alpha-antibody_af1011" title="Cotton Rat TNF-alpha Antibody"> <h4>Cotton Rat TNF-alpha Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/cotton-rat-tnf-alpha-antibody_af1011" title="Cotton Rat TNF-alpha Antibody"> AF1011 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/cotton-rat-tnf-alpha-antibody_af1011#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (1)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB, Neut </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Cotton Rat </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-18" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-18"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Cotton Rat </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB, Neut </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="af1011"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AF1011_Block_Neutralize_8743.jpg data-srcset=https://resources.bio-techne.com/images/products/antibody/TNF-alpha_AF1011_Block_Neutralize_8743.jpg alt="Cytotoxicity Induced by TNF-alpha and Neutralization by Cotton Rat TNF-alpha Antibody." title="Cytotoxicity Induced by TNF-alpha and Neutralization by Cotton Rat TNF-alpha Antibody." data-caption="Recombinant Cotton Rat TNF-a (Catalog # 1011-CR) induces cytotoxicity in the the L-929 mouse fibroblast cell line in a dose-dependent manner (orange line), as measured by crystal violet staining. Cytotoxicity elicited by Recombinant Cotton Rat TNF-a (1 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Cotton Rat TNF-a Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1011). The ND<SUB>50</SUB> is typically 0.01-0.05 µg/mL in the presence of the metabolic inhibitor actinomycin D (1 µg/mL)." data-badges="" data-application="Neutralization" data-header="Cotton Rat TNF-alpha Antibody, Catalog # AF1011" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-AF1011" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="AF1011"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-AF1011" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF1011"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF1011 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="AF1011-SP"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> AF1011-SP </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-AF1011-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=AF1011" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="novus" data-category="Primary Antibodies" data-id="NBP3-11332" data-name="TNF-alpha Antibody" data-position="19"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/tnf-alpha-antibody_nbp3-11332" title="TNF-alpha Antibody"> <h4>TNF-alpha Antibody </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="Novus Biologicals, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-novus-biologicals.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/tnf-alpha-antibody_nbp3-11332" title="TNF-alpha Antibody"> NBP3-11332 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/tnf-alpha-antibody_nbp3-11332#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (1)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> WB, ELISA </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Guinea Pig </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-19" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-19"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Guinea Pig </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Goat IgG Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> WB, ELISA </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="nbp3-11332"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="novus"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/TNF-alpha-Antibody-ELISA-NBP3-11332-img0001.jpg data-srcset=https://resources.bio-techne.com/images/products/TNF-alpha-Antibody-ELISA-NBP3-11332-img0001.jpg alt="ELISA: TNF-alpha Antibody [NBP3-11332]" title="ELISA: TNF-alpha Antibody [NBP3-11332]" data-caption="ELISA: TNF-alpha Antibody [NBP3-11332] - Recombinant Guinea PigTFN alpha detected using Goat anti Guinea Pig TFN alpha as the capture reagent and Goat anti Guinea Pig TFN alpha:Biotin as the detection reagent followed by Streptavidin:HRP." data-badges="" data-application="ELISA" data-header="TNF-alpha Antibody, Catalog # NBP3-11332" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-NBP3-11332" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="NBP3-11332"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-NBP3-11332" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="NBP3-11332"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> NBP3-11332 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="NBP3-11332-0.025mg"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> NBP3-11332-0.025mg </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-NBP3-11332-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=NBP3-11332" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> </div> <div id="search_results_bottom" class="row py-2 mb-5"> <div id="search_results_per_page" class="col-lg-9 col-sm-8 col-8"> <div class="d-inline-flex pt-1"> <div id="search_results_per_page_legend">Results Per Page</div> <a class="search_results_per_page_link px-2" rel="nofollow" href="/t/tnf-alpha?host=Goat&page=1&num_results=5">5</a> <a class="search_results_per_page_link px-2" rel="nofollow" href="/t/tnf-alpha?host=Goat&page=1&num_results=10">10</a> <span class="search_results_per_page_selected px-2">25</span> <a class="search_results_per_page_link px-2" rel="nofollow" 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