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Among 550 women reporting a lump as the first sign of breast cancer, those with this sign for 6-29 months compared to those with 1-6 months, had bigger tumors and more frequent axillary node involvement. Overall survival, however, was not significantly different in these two groups. Background. The relationship of delay in diagnosis of breast cancer to survival is uncertain. Methods. We evaluated the relationship of patient-reported duration of signs of breast cancer to survival in participants in a clinical trial of adjuvant hormonal therapy in Vietnam and China. Results. Among 550 women reporting a lump as the first sign of breast cancer and information on when this appeared, the median duration of this sign before diagnosis was 6 months. Comparing two groups of patients with durations of lumps 1-6 months and 6-29 months, the group with longer duration of lumps had larger tumors clinically and pathologically (p ¼ 0.0006, and p ¼ 0.004), more frequent axillary node involvement (p ¼ 0.008), and shorter but not statistically different disease-free and overall survival from the time of diagnosis (p ¼ 0.09 and 0.35, respectively). Conclusions. Breast cancer evolves slowly in the detectable period of its natural history. The impact of delays in diagnosis of less than 6 months is likely to be very limited; delays more than 6 months appear to have some, but marginal impact on survival.","publication_date":"2004,,","publication_name":"Breast Cancer Research and Treatment","grobid_abstract_attachment_id":"86416304"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"low","language":"en","title":"Duration of Signs and Survival in Premenopausal Women with Breast Cancer","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [216395122]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":86416304,"attachmentType":"pdf"}"><img alt="First page of “Duration of Signs and Survival in Premenopausal Women with Breast Cancer”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/86416304/mini_magick20220524-9784-rq1fbx.png?1653408459" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Duration of Signs and Survival in Premenopausal Women with Breast Cancer</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="216395122" href="https://independent.academia.edu/NguyenDuc400"><img alt="Profile image of Nguyen Duc" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/216395122/74821447/63323547/s65_nguyen.duc.png" />Nguyen Duc</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2004, Breast Cancer Research and Treatment</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">2 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 79835308; 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This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: We identified factors associated with delayed first consultation for breast symptoms (patient delay), delayed diagnosis after first consultation (doctor delay), and advanced pathologic stage at presentation among 180 women with breast cancer in Thailand. Methods: In this cross-sectional study 180 patients with invasive breast cancer were interviewed about potential risk factors and markers of delayed presentation. Patient delay was defined as time from onset of symptoms to first consultation with a health care provider, and doctor delay was defined as time from first consultation with a health care provider to diagnosis of breast cancer. 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The tumor's growth is uncontrolled by the body, expanding chaotically throughout the gland. The study aims to explore the epidemiological, clinical, and pathological aspects of breast cancer. We conducted a retrospective study at the Khmer-Soviet Friendship Hospital on 286 confirmed cases of breast cancer in women over a two-year period, from January 1, 2017, to December 31, 2018. Invasive ductal carcinoma was the predominant type, representing 263 cases (91.96%) of all malignant breast tumors. The majority of affected individuals were postmenopausal women aged 56-65, accounting for 107 cases (37.41%). Advancedstage tumors were identified in 222 cases (77.62%), with 38 cases (13.29%) exhibiting metastases to the lungs, liver, multiple organs, or brain. Mammographic anomalies, predominantly masses or asymmetry of density, along with suspicious microcalcifications, were detected in 98.57% of cases. Ultrasound findings included solid masses (100%) and axillary lymphadenopathy (74.48%). Pathological analysis revealed invasive ductal carcinomas with high Scarff-Bloom-Richardson prognostic factors (SBR II and III) in 89.51% and negative hormonal status in 9 of 32 cases. Awareness of breast selfexamination in detecting anomalies is crucial for women.. 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This study compared the presentation and results of screen-detected breast cancers with symptomatic breast cancers in two affiliated high-volume institutions, one of which was an assessment centre for BSS. The medical records of patients diagnosed with primary breast cancer at the Department of General Surgery, Singapore General Hospital and the Department of Surgical Oncology, National Cancer Centre, Singapore, during the period January 2002 to December 2003 were reviewed. Clinical and pathological comparisons were made between screen-detected lesions and symptomatic lesions. Of a total of 767 cases, 640 (83.4%) were invasive carcinomas and 127 (16.6%) were ductal carcinoma in-situ (DCIS) lesions. Only 13.4% of them were screen-detected. Compared to symptomatic cancers, screen-detected lesions were of smaller size (median size 18 versus 23 mm), a lower stage (stages 0-2, 95 versus 83.2%) and histologic grade (grade 1-2, 71 versus 60%), with a higher incidence of DCIS (31.0 versus 14.3%) and had higher rates of breast conservation (45.6 versus 28.2%) (all p-values &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05). By multivariate analysis, tumor palpability, tumor size &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;20 mm, nodal involvement, cerbB2 overexpression, and advanced disease stage were independent poor prognostic factors for disease-free survival, whereas nodal involvement, advanced disease, and recurrence predicted poor cancer-specific survival. However, there was no statistically significant difference in disease-free survival or cancer-specific survival between the two groups at a median follow-up of 38 months. Screening mammography has allowed the detection of smaller and hence oncologically more favorable lesions in Asian women. Although no significant survival benefit was demonstrated in our study, a longer period of follow-up is essential before the benefit of mortality reduction, as a result of mammography screening becomes evident in our population.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Early Detection of Breast Cancer through Population-Based Mammographic Screening in Asian Women: A Comparison Study between Screen-Detected and Symptomatic Breast Cancers","attachmentId":42131309,"attachmentType":"pdf","work_url":"https://www.academia.edu/18862747/Early_Detection_of_Breast_Cancer_through_Population_Based_Mammographic_Screening_in_Asian_Women_A_Comparison_Study_between_Screen_Detected_and_Symptomatic_Breast_Cancers","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/18862747/Early_Detection_of_Breast_Cancer_through_Population_Based_Mammographic_Screening_in_Asian_Women_A_Comparison_Study_between_Screen_Detected_and_Symptomatic_Breast_Cancers"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="25477180" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/25477180/Factors_influencing_the_stages_of_breast_cancer_at_the_time_of_diagnosis_in_Thai_women">Factors influencing the stages of breast cancer at the time of diagnosis in Thai women</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="48994413" href="https://independent.academia.edu/SiriornSindhu">Siriorn Sindhu</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Collegian, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Factors influencing the stages of breast cancer at the time of diagnosis in Thai women","attachmentId":45795175,"attachmentType":"pdf","work_url":"https://www.academia.edu/25477180/Factors_influencing_the_stages_of_breast_cancer_at_the_time_of_diagnosis_in_Thai_women","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/25477180/Factors_influencing_the_stages_of_breast_cancer_at_the_time_of_diagnosis_in_Thai_women"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="55175724" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/55175724/Factors_associated_with_delayed_diagnosis_of_breast_cancer_a_study_in_North_West_of_Iran">Factors associated with delayed diagnosis of breast cancer; a study in North-West of Iran</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47993092" href="https://independent.academia.edu/FirouzAmani">Firouz Amani</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Immunopathologia Persa</p><p class="ds-related-work--abstract ds2-5-body-sm">Introduction: Delayed diagnosis and treatment of breast cancer leads to the presentation of the disease in advanced stages necessitating more invasive surgical interventions, increasing health care costs and mortality rate, and finally reduced patients’ survival. Objectives: This study aimed to investigate the factors associated with delayed diagnosis of breast cancer in the north-west of Iran. Patients and Methods: This retrospective cross-sectional study was conducted on 70 breast cancer patients referred to the cancer registry of Ardabil city, north-west of Iran. The time from the presentation of clinical symptoms to the initiation of treatment was determined by interviews to identify the system and patients’ delays. The data was analyzed in SPSS 19 with the level of significance as P&lt;0.05. Results: The mean age of the patients was 43.3 ± 13.2 years. The means of total, patient, and system related delays were 9.4±1.6 weeks, 6.3 ± 9.9 weeks, and 3.1 ± 2.8 weeks respectively. Re...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Factors associated with delayed diagnosis of breast cancer; a study in North-West of Iran","attachmentId":71171957,"attachmentType":"pdf","work_url":"https://www.academia.edu/55175724/Factors_associated_with_delayed_diagnosis_of_breast_cancer_a_study_in_North_West_of_Iran","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/55175724/Factors_associated_with_delayed_diagnosis_of_breast_cancer_a_study_in_North_West_of_Iran"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="90480069" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/90480069/Predictive_Factors_for_Diagnosis_and_Treatment_Delay_in_Iranian_Women_with_Breast_Cancer">Predictive Factors for Diagnosis and Treatment Delay in Iranian Women with Breast Cancer</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="20561430" href="https://independent.academia.edu/nastaranmirfarhadi">nastaran mirfarhadi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Nursing and Midwifery Studies, 2017</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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data-collection-position="9" data-entity-id="61964344" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/61964344/Factors_Affecting_Delayed_Presentation_and_Diagnosis_of_Breast_Cancer_in_Asian_Developing_Countries_Women_A_Systematic_Review">Factors Affecting Delayed Presentation and Diagnosis of Breast Cancer in Asian Developing Countries Women: A Systematic Review</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="164330235" href="https://independent.academia.edu/FaridaSobri">Farida Sobri</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Asian Pacific Journal of Cancer Prevention</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Factors Affecting Delayed Presentation 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