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data-dom-id="Pill-react-component-7b6a532b-cccc-4c14-a0f9-aa04efee695c"></div> <div id="Pill-react-component-7b6a532b-cccc-4c14-a0f9-aa04efee695c"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Corrado Rubino</h3></div><div class="js-work-strip profile--work_container" data-work-id="79879170"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879170/Case_Report_Reconstruction_of_Traumatic_Defect_of_the_Lower_Third_of_the_Leg_Using_a_Combined_Therapy_Negative_Pressure_Wound_Therapy_Acellular_Dermal_Matrix_and_Skin_Graft"><img alt="Research paper thumbnail of Case Report Reconstruction of Traumatic Defect of the Lower Third of the Leg Using a Combined Therapy: Negative Pressure Wound Therapy, Acellular Dermal Matrix, and Skin Graft" class="work-thumbnail" src="https://attachments.academia-assets.com/86445735/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879170/Case_Report_Reconstruction_of_Traumatic_Defect_of_the_Lower_Third_of_the_Leg_Using_a_Combined_Therapy_Negative_Pressure_Wound_Therapy_Acellular_Dermal_Matrix_and_Skin_Graft">Case Report Reconstruction of Traumatic Defect of the Lower Third of the Leg Using a Combined Therapy: Negative Pressure Wound Therapy, Acellular Dermal Matrix, and Skin Graft</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The reconstruction of lower third of the leg is one of the most challenging problems for plastic ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The reconstruction of lower third of the leg is one of the most challenging problems for plastic and reconstructive surgeons and current approaches are still disappointing. We show an easy option to obtain a coverage of traumatic pretibial defects with good aesthetic and functional results: the association of negative pressure wound therapy, acellular dermal matrix, and skin graft. The choice of this combined therapy avoids other surgical procedures such as local perforator flaps and free flaps that require more operating time, special equipment, and adequate training.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f2058b3731f7d140ee6481210bde9244" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445735,"asset_id":79879170,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445735/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879170"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879170"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879170; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879170]").text(description); $(".js-view-count[data-work-id=79879170]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879170; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879170']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879170, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f2058b3731f7d140ee6481210bde9244" } } $('.js-work-strip[data-work-id=79879170]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879170,"title":"Case Report Reconstruction of Traumatic Defect of the Lower Third of the Leg Using a Combined Therapy: Negative Pressure Wound Therapy, Acellular Dermal Matrix, and Skin Graft","translated_title":"","metadata":{"abstract":"The reconstruction of lower third of the leg is one of the most challenging problems for plastic and reconstructive surgeons and current approaches are still disappointing. 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The choice of this combined therapy avoids other surgical procedures such as local perforator flaps and free flaps that require more operating time, special equipment, and adequate training.","internal_url":"https://www.academia.edu/79879170/Case_Report_Reconstruction_of_Traumatic_Defect_of_the_Lower_Third_of_the_Leg_Using_a_Combined_Therapy_Negative_Pressure_Wound_Therapy_Acellular_Dermal_Matrix_and_Skin_Graft","translated_internal_url":"","created_at":"2022-05-25T02:30:42.074-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86445735,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445735/thumbnails/1.jpg","file_name":"783812.pdf","download_url":"https://www.academia.edu/attachments/86445735/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Case_Report_Reconstruction_of_Traumatic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445735/783812-libre.pdf?1653471926=\u0026response-content-disposition=attachment%3B+filename%3DCase_Report_Reconstruction_of_Traumatic.pdf\u0026Expires=1732809418\u0026Signature=hRWvEj478cAyEzJrJu73RSdCYASKem1Xzfwvb5F97KxPAHgCR4QGXJG7b3E29C2S~psQzhnbUznNR6XYor70vxAy30s-gzm47xjBbwSA-RfflK7eKhw0wruV5gSWp4yzs026NDb3oPw0FgMzO0Gu3ONjwLYKGamCogB7h6IMYIjYXqBTDZGsS89OLtm6cqLHepAqCHlguxH52szKB6lA5oJzLOApXQT9khdtigmWNwft9YMWBI2O-Rbjkz~HQJpHk8LNZlGWa4FLFYJRd6NDA6qIlG4papkQ51Klj-rCsaJ8aoAsn3CkfwsRaSBO3bzK7PC17Eo9WCwL6IL567w5dw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Case_Report_Reconstruction_of_Traumatic_Defect_of_the_Lower_Third_of_the_Leg_Using_a_Combined_Therapy_Negative_Pressure_Wound_Therapy_Acellular_Dermal_Matrix_and_Skin_Graft","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[{"id":86445735,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445735/thumbnails/1.jpg","file_name":"783812.pdf","download_url":"https://www.academia.edu/attachments/86445735/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Case_Report_Reconstruction_of_Traumatic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445735/783812-libre.pdf?1653471926=\u0026response-content-disposition=attachment%3B+filename%3DCase_Report_Reconstruction_of_Traumatic.pdf\u0026Expires=1732809418\u0026Signature=hRWvEj478cAyEzJrJu73RSdCYASKem1Xzfwvb5F97KxPAHgCR4QGXJG7b3E29C2S~psQzhnbUznNR6XYor70vxAy30s-gzm47xjBbwSA-RfflK7eKhw0wruV5gSWp4yzs026NDb3oPw0FgMzO0Gu3ONjwLYKGamCogB7h6IMYIjYXqBTDZGsS89OLtm6cqLHepAqCHlguxH52szKB6lA5oJzLOApXQT9khdtigmWNwft9YMWBI2O-Rbjkz~HQJpHk8LNZlGWa4FLFYJRd6NDA6qIlG4papkQ51Klj-rCsaJ8aoAsn3CkfwsRaSBO3bzK7PC17Eo9WCwL6IL567w5dw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":20760591,"url":"http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1077.8419\u0026rep=rep1\u0026type=pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879168"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879168/Complications_after_breast_augmentation_with_hyaluronic_acid_a_case_report"><img alt="Research paper thumbnail of Complications after breast augmentation with hyaluronic acid: a case report" class="work-thumbnail" src="https://attachments.academia-assets.com/86445677/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879168/Complications_after_breast_augmentation_with_hyaluronic_acid_a_case_report">Complications after breast augmentation with hyaluronic acid: a case report</a></div><div class="wp-workCard_item"><span>Gland Surgery</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8797d9ad8bc166d3350b0183b990e5ef" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445677,"asset_id":79879168,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445677/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879168"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879168"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879168; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879168]").text(description); $(".js-view-count[data-work-id=79879168]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879168; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879168']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879168, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Over time, various techniques of breast augmentation have been described, both through the use of alloplastic materials and autologous tissues: implants, fat grafting, flap surgery, and injectable fillers. According to the international current trend to perform minimally invasive procedure, injectable fillers have progressively increased their uses and notoriety in aesthetic medicine. Among the various available products, hyaluronic acid is likely to be the most popular synthetic filler all over the world. Nowadays many brands are on the market and this paper focuses on Macrolane which is a NASHA-based (stabilized hyaluronic acid of non-animal origin) filler. However, although highly biocompatible, as any material, foreign to our body, also hyaluronic acid fillers undergo a process of degradation and disposal. In our work, we report the first case in literature of migration of Macrolane in an axillary lymph node in a 45-year-old woman three years after injection for breast augmentation and its related management. The aim of the paper is to discuss and underline further complications and their treatment besides the ones already described in literature in order to provide a deeper knowledge concerning the use and the side effects of injectable fillers in aesthetic medicine.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Gland Surgery","grobid_abstract_attachment_id":86445677},"translated_abstract":null,"internal_url":"https://www.academia.edu/79879168/Complications_after_breast_augmentation_with_hyaluronic_acid_a_case_report","translated_internal_url":"","created_at":"2022-05-25T02:30:41.854-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86445677,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445677/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/86445677/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Complications_after_breast_augmentation.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445677/pdf-libre.pdf?1653471938=\u0026response-content-disposition=attachment%3B+filename%3DComplications_after_breast_augmentation.pdf\u0026Expires=1732809418\u0026Signature=JEpl2Sy5gTZXtnQgiURMzT30ri3Rh1YXEIvL0YmW8TRUl41jnOt~HhRkq2FkNxskpeHRl~J~ApI0c-6BnwTyR3oJssj8YzfiQ7vft~C8AjiOSQ0gUAC-hg9EZZueORx5FwshW5GGuNEIF7HplbR4hx42X8n6a3KJyQata-NRnS6VfLgHbq3S~mtb4bDBicPVSZiMaD8lxtZXsE6I0qqFvDqIN~b-pcfjY3MfdzZt1AyeI3rL6g1MCQwlhjP4tBMCuKlqa7g78ludeVuA7mlB5mt~3oJWeixs7xcK72HNpnpRy7256X1Jq31QT067OWom34Vamync1kMe4Cck3MHDKA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Complications_after_breast_augmentation_with_hyaluronic_acid_a_case_report","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[{"id":86445677,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445677/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/86445677/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Complications_after_breast_augmentation.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445677/pdf-libre.pdf?1653471938=\u0026response-content-disposition=attachment%3B+filename%3DComplications_after_breast_augmentation.pdf\u0026Expires=1732809418\u0026Signature=JEpl2Sy5gTZXtnQgiURMzT30ri3Rh1YXEIvL0YmW8TRUl41jnOt~HhRkq2FkNxskpeHRl~J~ApI0c-6BnwTyR3oJssj8YzfiQ7vft~C8AjiOSQ0gUAC-hg9EZZueORx5FwshW5GGuNEIF7HplbR4hx42X8n6a3KJyQata-NRnS6VfLgHbq3S~mtb4bDBicPVSZiMaD8lxtZXsE6I0qqFvDqIN~b-pcfjY3MfdzZt1AyeI3rL6g1MCQwlhjP4tBMCuKlqa7g78ludeVuA7mlB5mt~3oJWeixs7xcK72HNpnpRy7256X1Jq31QT067OWom34Vamync1kMe4Cck3MHDKA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":86445676,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445676/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/86445676/download_file","bulk_download_file_name":"Complications_after_breast_augmentation.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445676/pdf-libre.pdf?1653471943=\u0026response-content-disposition=attachment%3B+filename%3DComplications_after_breast_augmentation.pdf\u0026Expires=1732809418\u0026Signature=XT8mTXwsPUhoM9a1jSfwTXisOERU0nvJGLxFizfVwaku7R26BLHzaK9D67i7w-I9E1o6t0YIBE0IpTzPk4mS1ndO5scokHITiCLed-AiBK7RuMXOAOD8LiVRYfslGT3bjJc-9X5HeCgq0IZdbralN69~0dSnlRPtq0vT-tybKq5GOM5GSCRVMrIv9M5lL0Hvly2vPxjkMc6WRYzHKthS6CzpGn6R~LD5iDjaX6EjZ7z0JVoWkHPiksCHcwdGl6E86g0ccQ9wLR9cGkenwjU5RPdTxc12fGneAWt-MkKU42oUdcNkgGeG3KVNQhm9eJcRIfZVJ29WwlntgiFaROPNIw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"}],"urls":[{"id":20760590,"url":"http://gs.amegroups.com/article/download/54727/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879166"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879166/Low_Versus_High_Vacuum_Suction_Drainage_of_the_Submuscular_Pocket_in_Primary_Breast_Reconstruction_A_Retrospective_Study"><img alt="Research paper thumbnail of Low Versus High Vacuum Suction Drainage of the Submuscular Pocket in Primary Breast Reconstruction: A Retrospective Study" class="work-thumbnail" src="https://attachments.academia-assets.com/86445736/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879166/Low_Versus_High_Vacuum_Suction_Drainage_of_the_Submuscular_Pocket_in_Primary_Breast_Reconstruction_A_Retrospective_Study">Low Versus High Vacuum Suction Drainage of the Submuscular Pocket in Primary Breast Reconstruction: A Retrospective Study</a></div><div class="wp-workCard_item"><span>Annals of plastic surgery</span><span>, Jan 31, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Placement of suction drainage in submuscular pockets is routinely performed in breast reconstruct...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Placement of suction drainage in submuscular pockets is routinely performed in breast reconstruction. Days of drain permanence (DDP) are associated with hospital stay and related health care costs. The aims of this study are to retrospectively compare data related to DDP and total drainage volume between high and low vacuum suction drainage groups and to identify correlations with patient or surgery-related factors. We retrospectively analyzed data of 100 patients undergoing immediate or delayed breast reconstruction with expanders and implants. We considered 2 groups depending on suction pressure applied by 2 different surgical teams: group A (number, 50 patients) with high vacuum suction and group B (number, 50 patients) with low vacuum suction. Days of drain permanence was not significantly different between group A and group B (P = 0.451). The same was found for total drainage volume (P = 0.183). The distribution of DDP was statistically different only between patients with or w...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="349d2889ebb76b946a0c1fcec163f1fa" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445736,"asset_id":79879166,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445736/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879166"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879166"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879166; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879166]").text(description); $(".js-view-count[data-work-id=79879166]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879166; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879166']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879166, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "349d2889ebb76b946a0c1fcec163f1fa" } } $('.js-work-strip[data-work-id=79879166]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879166,"title":"Low Versus High Vacuum Suction Drainage of the Submuscular Pocket in Primary Breast Reconstruction: A Retrospective Study","translated_title":"","metadata":{"abstract":"Placement of suction drainage in submuscular pockets is routinely performed in breast reconstruction. Days of drain permanence (DDP) are associated with hospital stay and related health care costs. The aims of this study are to retrospectively compare data related to DDP and total drainage volume between high and low vacuum suction drainage groups and to identify correlations with patient or surgery-related factors. We retrospectively analyzed data of 100 patients undergoing immediate or delayed breast reconstruction with expanders and implants. We considered 2 groups depending on suction pressure applied by 2 different surgical teams: group A (number, 50 patients) with high vacuum suction and group B (number, 50 patients) with low vacuum suction. Days of drain permanence was not significantly different between group A and group B (P = 0.451). The same was found for total drainage volume (P = 0.183). The distribution of DDP was statistically different only between patients with or w...","ai_title_tag":"High vs Low Vacuum Drainage in Breast Reconstruction Outcomes","publication_date":{"day":31,"month":1,"year":2017,"errors":{}},"publication_name":"Annals of plastic surgery"},"translated_abstract":"Placement of suction drainage in submuscular pockets is routinely performed in breast reconstruction. Days of drain permanence (DDP) are associated with hospital stay and related health care costs. The aims of this study are to retrospectively compare data related to DDP and total drainage volume between high and low vacuum suction drainage groups and to identify correlations with patient or surgery-related factors. We retrospectively analyzed data of 100 patients undergoing immediate or delayed breast reconstruction with expanders and implants. We considered 2 groups depending on suction pressure applied by 2 different surgical teams: group A (number, 50 patients) with high vacuum suction and group B (number, 50 patients) with low vacuum suction. Days of drain permanence was not significantly different between group A and group B (P = 0.451). The same was found for total drainage volume (P = 0.183). The distribution of DDP was statistically different only between patients with or w...","internal_url":"https://www.academia.edu/79879166/Low_Versus_High_Vacuum_Suction_Drainage_of_the_Submuscular_Pocket_in_Primary_Breast_Reconstruction_A_Retrospective_Study","translated_internal_url":"","created_at":"2022-05-25T02:30:41.687-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86445736,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445736/thumbnails/1.jpg","file_name":"SAP.000000000000124620220525-1-16e6in3.pdf","download_url":"https://www.academia.edu/attachments/86445736/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Low_Versus_High_Vacuum_Suction_Drainage.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445736/SAP.000000000000124620220525-1-16e6in3-libre.pdf?1653471926=\u0026response-content-disposition=attachment%3B+filename%3DLow_Versus_High_Vacuum_Suction_Drainage.pdf\u0026Expires=1732809418\u0026Signature=S8cQzo1kmF2Uqw2unFuospG46uNBWKTU2n5ciy5v6DPSe1dYQZbT0DDNGdxtMXPzxYVmZGCTayrOGDD95Xr4R8DNiKbAtKwWboDO5H-Z3E~5NHN669HrvfzEb5QgT8MCh5PqqDkJ6qY95RTbIxScMEb6vpQeCApwglouZG3u8XDXMkPr8LC2byZgIWzPi5ClUaYIqDgxSj4Fcdywcf45Tw96UpajZK3Uq0nfve7zBT13QqBvs8GB64z1WvS-0GFCyowj6BWUCMuwKBd7Fjvfjzwdlb7vG~UniDDtrxYOWKwEnwvhBveGHueXLt94dhLksVN3YN6jAnrmat3buEqr0w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Low_Versus_High_Vacuum_Suction_Drainage_of_the_Submuscular_Pocket_in_Primary_Breast_Reconstruction_A_Retrospective_Study","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[{"id":86445736,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445736/thumbnails/1.jpg","file_name":"SAP.000000000000124620220525-1-16e6in3.pdf","download_url":"https://www.academia.edu/attachments/86445736/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Low_Versus_High_Vacuum_Suction_Drainage.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445736/SAP.000000000000124620220525-1-16e6in3-libre.pdf?1653471926=\u0026response-content-disposition=attachment%3B+filename%3DLow_Versus_High_Vacuum_Suction_Drainage.pdf\u0026Expires=1732809418\u0026Signature=S8cQzo1kmF2Uqw2unFuospG46uNBWKTU2n5ciy5v6DPSe1dYQZbT0DDNGdxtMXPzxYVmZGCTayrOGDD95Xr4R8DNiKbAtKwWboDO5H-Z3E~5NHN669HrvfzEb5QgT8MCh5PqqDkJ6qY95RTbIxScMEb6vpQeCApwglouZG3u8XDXMkPr8LC2byZgIWzPi5ClUaYIqDgxSj4Fcdywcf45Tw96UpajZK3Uq0nfve7zBT13QqBvs8GB64z1WvS-0GFCyowj6BWUCMuwKBd7Fjvfjzwdlb7vG~UniDDtrxYOWKwEnwvhBveGHueXLt94dhLksVN3YN6jAnrmat3buEqr0w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":1185895,"name":"Breast Reconstruction","url":"https://www.academia.edu/Documents/in/Breast_Reconstruction"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879164"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879164/Expression_of_the_anti_apoptotic_BAG3_protein_in_leg_venous_ulcerative_tissues"><img alt="Research paper thumbnail of Expression of the anti-apoptotic BAG3 protein in leg venous ulcerative tissues" class="work-thumbnail" src="https://attachments.academia-assets.com/86445733/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879164/Expression_of_the_anti_apoptotic_BAG3_protein_in_leg_venous_ulcerative_tissues">Expression of the anti-apoptotic BAG3 protein in leg venous ulcerative tissues</a></div><div class="wp-workCard_item"><span>Cell Death Discovery</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="273d9ad2a1683a08eab475af96eabb1b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445733,"asset_id":79879164,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445733/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879164"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879164"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879164; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879161"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879161/The_localization_of_the_distal_perforators_of_posterior_tibial_artery_a_cadaveric_study_for_the_correct_planning_of_medial_adipofascial_flaps"><img alt="Research paper thumbnail of The localization of the distal perforators of posterior tibial artery: a cadaveric study for the correct planning of medial adipofascial flaps" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879161/The_localization_of_the_distal_perforators_of_posterior_tibial_artery_a_cadaveric_study_for_the_correct_planning_of_medial_adipofascial_flaps">The localization of the distal perforators of posterior tibial artery: a cadaveric study for the correct planning of medial adipofascial flaps</a></div><div class="wp-workCard_item"><span>Surgical and Radiologic Anatomy</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The adipofascial flap, introduced by Lin in 1994, has many advantages compared to fasciocutaneous...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The adipofascial flap, introduced by Lin in 1994, has many advantages compared to fasciocutaneous or free flaps. Its dissection is relatively easy and fast with low donor-site morbidity, and it does not alter the shape of the leg. The aim of this dissection study is to evaluate the anatomic localization of the most distal perforator of the posterior tibial vessels to provide an anatomical rationale for the safe harvesting of distally based medial adipofascial flaps of the leg. 30 Lower limbs from 15 cadavers were used for this study. The most distal perforator from posterior tibial perforator artery, accompanied by at least one vein, was identified and its distance from the medial malleolus was noted. A distal perforator was found in all specimens; the mean caliber was 0.77 mm. In all cases, the perforator artery passed in the septum between flexor hallucis longus m. and flexor digitorum longus m. and was accompanied by two veins. In our series, the distance between the lowest perforator and the medial malleolus ranged from 3.5 to 8.2 cm. The median was 6.75 cm, the 5th percentile 4 cm and the 95th percentile 8.1 cm. The mean distance of the perforator from the medial tibial border was 1.23 cm. The mean ratio between the distance of perforator from the medial malleolus and the total leg length was 21%. Compared to all previous researches, our study has found more distal perforators from posterior tibial perforator artery. This fact may have important clinical consequences, because the anteromedial adipofascial flap would cover more distal soft tissue defects. Moreover, our data suggest some safety parameters to make the rising of a medial adipofascial leg flap safer in surgical practice.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879161"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879161"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879161; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879161]").text(description); $(".js-view-count[data-work-id=79879161]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879161; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879161']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879161, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=79879161]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879161,"title":"The localization of the distal perforators of posterior tibial artery: a cadaveric study for the correct planning of medial adipofascial flaps","translated_title":"","metadata":{"abstract":"The adipofascial flap, introduced by Lin in 1994, has many advantages compared to fasciocutaneous or free flaps. Its dissection is relatively easy and fast with low donor-site morbidity, and it does not alter the shape of the leg. The aim of this dissection study is to evaluate the anatomic localization of the most distal perforator of the posterior tibial vessels to provide an anatomical rationale for the safe harvesting of distally based medial adipofascial flaps of the leg. 30 Lower limbs from 15 cadavers were used for this study. The most distal perforator from posterior tibial perforator artery, accompanied by at least one vein, was identified and its distance from the medial malleolus was noted. A distal perforator was found in all specimens; the mean caliber was 0.77 mm. In all cases, the perforator artery passed in the septum between flexor hallucis longus m. and flexor digitorum longus m. and was accompanied by two veins. In our series, the distance between the lowest perforator and the medial malleolus ranged from 3.5 to 8.2 cm. The median was 6.75 cm, the 5th percentile 4 cm and the 95th percentile 8.1 cm. The mean distance of the perforator from the medial tibial border was 1.23 cm. The mean ratio between the distance of perforator from the medial malleolus and the total leg length was 21%. Compared to all previous researches, our study has found more distal perforators from posterior tibial perforator artery. This fact may have important clinical consequences, because the anteromedial adipofascial flap would cover more distal soft tissue defects. Moreover, our data suggest some safety parameters to make the rising of a medial adipofascial leg flap safer in surgical practice.","publisher":"Springer Science and Business Media LLC","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Surgical and Radiologic Anatomy"},"translated_abstract":"The adipofascial flap, introduced by Lin in 1994, has many advantages compared to fasciocutaneous or free flaps. Its dissection is relatively easy and fast with low donor-site morbidity, and it does not alter the shape of the leg. The aim of this dissection study is to evaluate the anatomic localization of the most distal perforator of the posterior tibial vessels to provide an anatomical rationale for the safe harvesting of distally based medial adipofascial flaps of the leg. 30 Lower limbs from 15 cadavers were used for this study. The most distal perforator from posterior tibial perforator artery, accompanied by at least one vein, was identified and its distance from the medial malleolus was noted. A distal perforator was found in all specimens; the mean caliber was 0.77 mm. In all cases, the perforator artery passed in the septum between flexor hallucis longus m. and flexor digitorum longus m. and was accompanied by two veins. In our series, the distance between the lowest perforator and the medial malleolus ranged from 3.5 to 8.2 cm. The median was 6.75 cm, the 5th percentile 4 cm and the 95th percentile 8.1 cm. The mean distance of the perforator from the medial tibial border was 1.23 cm. The mean ratio between the distance of perforator from the medial malleolus and the total leg length was 21%. Compared to all previous researches, our study has found more distal perforators from posterior tibial perforator artery. This fact may have important clinical consequences, because the anteromedial adipofascial flap would cover more distal soft tissue defects. Moreover, our data suggest some safety parameters to make the rising of a medial adipofascial leg flap safer in surgical practice.","internal_url":"https://www.academia.edu/79879161/The_localization_of_the_distal_perforators_of_posterior_tibial_artery_a_cadaveric_study_for_the_correct_planning_of_medial_adipofascial_flaps","translated_internal_url":"","created_at":"2022-05-25T02:30:41.340-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_localization_of_the_distal_perforators_of_posterior_tibial_artery_a_cadaveric_study_for_the_correct_planning_of_medial_adipofascial_flaps","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":1000427,"name":"Reference Values","url":"https://www.academia.edu/Documents/in/Reference_Values"}],"urls":[{"id":20760588,"url":"http://link.springer.com/content/pdf/10.1007/s00276-014-1275-9.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879159"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879159/Transverse_Upper_Gracilis_Flap_with_Implant_In_Postmastectomy_Breast_Reconstruction_a_Case_Report"><img alt="Research paper thumbnail of Transverse Upper Gracilis Flap with Implant In Postmastectomy Breast Reconstruction: a Case Report" class="work-thumbnail" src="https://attachments.academia-assets.com/86445737/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879159/Transverse_Upper_Gracilis_Flap_with_Implant_In_Postmastectomy_Breast_Reconstruction_a_Case_Report">Transverse Upper Gracilis Flap with Implant In Postmastectomy Breast Reconstruction: a Case Report</a></div><div class="wp-workCard_item"><span>Microsurgery</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9cd080893f3f30bb0d9e8c5e1b19f0fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445737,"asset_id":79879159,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445737/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879159"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879159"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879159; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879159]").text(description); $(".js-view-count[data-work-id=79879159]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879159; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879159']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879159, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9cd080893f3f30bb0d9e8c5e1b19f0fe" } } $('.js-work-strip[data-work-id=79879159]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879159,"title":"Transverse Upper Gracilis Flap with Implant In Postmastectomy Breast Reconstruction: a Case Report","translated_title":"","metadata":{"publisher":"Wiley","grobid_abstract":"Autologous flaps can be used in combination with prosthesis in postmastectomy breast reconstruction. The deep inferior epigastric perforator (DIEP) flap is considered the preferred choice among autologous tissue transfer techniques. However, in patients with a peculiar figure (moderately large breasts and large thighs with flat stomach), who cannot use their abdominal tissue, the transverse upper gracilis (TUG) flap with implant is investigated as a further option for breast reconstruction. This report presents a patient who underwent the TUG flap plus implant reconstruction. A bilateral skin-sparing mastectomy was performed removing 340 g for each breast. The volume of the TUG flaps was 225 g (left) and 250 g (right). Preoperative volumes were restored by placing under the TUG muscle a round textured implant. No complications occurred during the postoperative period both in the recipient and donor site and the outcomes of the procedure were good. In cases where the use of the DIEP flap is not possible because of past laparotomies or inadequate abdominal volume, the TUG flap plus implant may be considered as a valid alternative.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Microsurgery","grobid_abstract_attachment_id":86445737},"translated_abstract":null,"internal_url":"https://www.academia.edu/79879159/Transverse_Upper_Gracilis_Flap_with_Implant_In_Postmastectomy_Breast_Reconstruction_a_Case_Report","translated_internal_url":"","created_at":"2022-05-25T02:30:41.179-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86445737,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445737/thumbnails/1.jpg","file_name":"micr.2216520220525-1-1sde0by.pdf","download_url":"https://www.academia.edu/attachments/86445737/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Transverse_Upper_Gracilis_Flap_with_Impl.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445737/micr.2216520220525-1-1sde0by-libre.pdf?1653471923=\u0026response-content-disposition=attachment%3B+filename%3DTransverse_Upper_Gracilis_Flap_with_Impl.pdf\u0026Expires=1732809418\u0026Signature=IU8HKyBBgdPy0jIQh5pkSi6DTBEQCkISSIWoh~jnAnkqBXcmKnWr-uCPPzlIkkb8Kj1NUWhx-8oBIbdRf-ns6UHCJEWiEFbRCYAENrnuPu9ZbBmd8G4cq7UNy77N1EGEoiTK8p5LPhWsqyxOeK8ehIBXc92~WVAfsj0jIFZDDkc2JC4B~A4VMyvk-N24UotQ8x1g9hHWkFmfBpBXA-DUIFS7jFxAjsJsAZs-F0DCQfYL6xMiZLLtUZDAiaF15Q-CoI3SEGFFs6dfktiXqkZS0rtxag2By8d8Fv0lJe87tAOJnIPjnwoESC0vvXz6D06jx3hxaysZPloZCWiAVyuTrw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Transverse_Upper_Gracilis_Flap_with_Implant_In_Postmastectomy_Breast_Reconstruction_a_Case_Report","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[{"id":86445737,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445737/thumbnails/1.jpg","file_name":"micr.2216520220525-1-1sde0by.pdf","download_url":"https://www.academia.edu/attachments/86445737/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Transverse_Upper_Gracilis_Flap_with_Impl.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445737/micr.2216520220525-1-1sde0by-libre.pdf?1653471923=\u0026response-content-disposition=attachment%3B+filename%3DTransverse_Upper_Gracilis_Flap_with_Impl.pdf\u0026Expires=1732809418\u0026Signature=IU8HKyBBgdPy0jIQh5pkSi6DTBEQCkISSIWoh~jnAnkqBXcmKnWr-uCPPzlIkkb8Kj1NUWhx-8oBIbdRf-ns6UHCJEWiEFbRCYAENrnuPu9ZbBmd8G4cq7UNy77N1EGEoiTK8p5LPhWsqyxOeK8ehIBXc92~WVAfsj0jIFZDDkc2JC4B~A4VMyvk-N24UotQ8x1g9hHWkFmfBpBXA-DUIFS7jFxAjsJsAZs-F0DCQfYL6xMiZLLtUZDAiaF15Q-CoI3SEGFFs6dfktiXqkZS0rtxag2By8d8Fv0lJe87tAOJnIPjnwoESC0vvXz6D06jx3hxaysZPloZCWiAVyuTrw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4228,"name":"Skeletal muscle biology","url":"https://www.academia.edu/Documents/in/Skeletal_muscle_biology"},{"id":10126,"name":"Microsurgery","url":"https://www.academia.edu/Documents/in/Microsurgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":231720,"name":"Mastectomy","url":"https://www.academia.edu/Documents/in/Mastectomy"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":1146774,"name":"Thigh","url":"https://www.academia.edu/Documents/in/Thigh"},{"id":3724721,"name":"Surgical Flaps","url":"https://www.academia.edu/Documents/in/Surgical_Flaps"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879158"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879158/Secondary_shaping_of_the_free_TRAM_an_inferior_pedicle_reduction_mammaplasty"><img alt="Research paper thumbnail of Secondary shaping of the free TRAM: an inferior pedicle reduction mammaplasty" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879158/Secondary_shaping_of_the_free_TRAM_an_inferior_pedicle_reduction_mammaplasty">Secondary shaping of the free TRAM: an inferior pedicle reduction mammaplasty</a></div><div class="wp-workCard_item"><span>Journal of Plastic, Reconstructive & Aesthetic Surgery</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Secondary shaping of the transverse rectus abdominis myocutaneous (TRAM) flap is a routine treatm...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Secondary shaping of the transverse rectus abdominis myocutaneous (TRAM) flap is a routine treatment, and includes liposuction, skin excision, inframammary fold replacement, dermal fat grafts or lipofilling. Major flap revision may include an augmentation procedure with implants or expanders. We present an inferior pedicle breast reduction in a woman who underwent breast reconstruction using a free TRAM flap. To our knowledge, there are no reports about reduction mammaplasty or mastopexy in Free TRAM flap breast reconstruction. Reduction mammaplasty should be regarded as a valuable option in free TRAM or deep inferior epigastric perforator secondary reshaping.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879158"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879158"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879158; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879158]").text(description); $(".js-view-count[data-work-id=79879158]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879158; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879158']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879158, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=79879158]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879158,"title":"Secondary shaping of the free TRAM: an inferior pedicle reduction mammaplasty","translated_title":"","metadata":{"abstract":"Secondary shaping of the transverse rectus abdominis myocutaneous (TRAM) flap is a routine treatment, and includes liposuction, skin excision, inframammary fold replacement, dermal fat grafts or lipofilling. Major flap revision may include an augmentation procedure with implants or expanders. We present an inferior pedicle breast reduction in a woman who underwent breast reconstruction using a free TRAM flap. To our knowledge, there are no reports about reduction mammaplasty or mastopexy in Free TRAM flap breast reconstruction. Reduction mammaplasty should be regarded as a valuable option in free TRAM or deep inferior epigastric perforator secondary reshaping.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Journal of Plastic, Reconstructive \u0026 Aesthetic Surgery"},"translated_abstract":"Secondary shaping of the transverse rectus abdominis myocutaneous (TRAM) flap is a routine treatment, and includes liposuction, skin excision, inframammary fold replacement, dermal fat grafts or lipofilling. Major flap revision may include an augmentation procedure with implants or expanders. We present an inferior pedicle breast reduction in a woman who underwent breast reconstruction using a free TRAM flap. To our knowledge, there are no reports about reduction mammaplasty or mastopexy in Free TRAM flap breast reconstruction. Reduction mammaplasty should be regarded as a valuable option in free TRAM or deep inferior epigastric perforator secondary reshaping.","internal_url":"https://www.academia.edu/79879158/Secondary_shaping_of_the_free_TRAM_an_inferior_pedicle_reduction_mammaplasty","translated_internal_url":"","created_at":"2022-05-25T02:30:41.014-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Secondary_shaping_of_the_free_TRAM_an_inferior_pedicle_reduction_mammaplasty","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":100533,"name":"Breast Reduction","url":"https://www.academia.edu/Documents/in/Breast_Reduction"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies"},{"id":231720,"name":"Mastectomy","url":"https://www.academia.edu/Documents/in/Mastectomy"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":2482067,"name":"Reoperation","url":"https://www.academia.edu/Documents/in/Reoperation"},{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms"},{"id":3724721,"name":"Surgical Flaps","url":"https://www.academia.edu/Documents/in/Surgical_Flaps"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879157"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879157/Is_mammary_reconstruction_with_the_anatomical_Becker_expander_a_simple_procedure_Complications_and_hidden_problems_leading_to_secondary_surgical_procedures_A_follow_up_study"><img alt="Research paper thumbnail of Is mammary reconstruction with the anatomical Becker expander a simple procedure? Complications and hidden problems leading to secondary surgical procedures: A follow-up study" class="work-thumbnail" src="https://attachments.academia-assets.com/86445741/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879157/Is_mammary_reconstruction_with_the_anatomical_Becker_expander_a_simple_procedure_Complications_and_hidden_problems_leading_to_secondary_surgical_procedures_A_follow_up_study">Is mammary reconstruction with the anatomical Becker expander a simple procedure? Complications and hidden problems leading to secondary surgical procedures: A follow-up study</a></div><div class="wp-workCard_item"><span>Journal of Plastic, Reconstructive & Aesthetic Surgery</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a599d0bd1062ee35bdb970a47a635439" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445741,"asset_id":79879157,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445741/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879157"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879157"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879157; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879157]").text(description); $(".js-view-count[data-work-id=79879157]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879157; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879157']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879157, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a599d0bd1062ee35bdb970a47a635439" } } $('.js-work-strip[data-work-id=79879157]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879157,"title":"Is mammary reconstruction with the anatomical Becker expander a simple procedure? Complications and hidden problems leading to secondary surgical procedures: A follow-up study","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Debate over the role of Becker expander implants (BEIs) in breast reconstruction is still ongoing. There are no clear indications for BEI use. The main indications for BEI use are one-stage breast reconstruction procedure and congenital breast deformities correction, due to the postoperative ability to vary BEI volume. Recent studies showed that BEIs were removed 5 years after mammary reconstruction in 68% of operated patients. This entails a further surgical procedure. BEIs should not, therefore, be regarded as one-stage prostheses. We performed a case-series study of breast reconstructions with anatomically shaped Becker-35盲 implants, in order to highlight complications and to flag unseen problems, which might entail a second surgical procedure. A total of 229 patients, reconstructed from 2005 to 2010, were enrolled in this study. Data relating to implant type, volume, mean operative time and complications were recorded. All the patients underwent the same surgical procedure. The minimum follow-up period was 18 months. During a 5-year follow-up, 99 patients required secondary surgery to correct their complications or sequelae; 46 of them underwent BEI removal within 2 years of implantation, 56 within 3 years, 65 within 4 years and 74 within 5 years. Our findings show that two different sorts of complications can arise with these devices, leading to premature implant removal, one common to any breast implant and one peculiar to BEIs. The Becker implant is a permanent expander. Surgeons must, therefore, be aware that, once positioned, the Becker expander cannot be adjusted at a later date, as in two-stage expander/prosthesis reconstructions for instance. Surgeons must have a clear understanding","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Journal of Plastic, Reconstructive \u0026 Aesthetic Surgery","grobid_abstract_attachment_id":86445741},"translated_abstract":null,"internal_url":"https://www.academia.edu/79879157/Is_mammary_reconstruction_with_the_anatomical_Becker_expander_a_simple_procedure_Complications_and_hidden_problems_leading_to_secondary_surgical_procedures_A_follow_up_study","translated_internal_url":"","created_at":"2022-05-25T02:30:40.864-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86445741,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445741/thumbnails/1.jpg","file_name":"j.bjps.2013.02.00420220525-1-m43ckz.pdf","download_url":"https://www.academia.edu/attachments/86445741/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Is_mammary_reconstruction_with_the_anato.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445741/j.bjps.2013.02.00420220525-1-m43ckz-libre.pdf?1653471925=\u0026response-content-disposition=attachment%3B+filename%3DIs_mammary_reconstruction_with_the_anato.pdf\u0026Expires=1732809418\u0026Signature=PDRS3h70itliNQzgAK7P7NwR5lKv6iAr~5kWJudVUIEFBpM082aLZXGZ1bTol-HYoIhONemInxcq1eN9b0LBGRMpw4jl6mxGqWuitD2QCN0oJ3NgHSn1K0sg3exjuo9VHhR57CH22n5Igb6HqKJlNpbgIcyWJ0wGTG6dBrAotSW0D14D~~2BiLDANZXCy4EoIjltRYwoukibx4ti5EAZ~APvhI63~HKf8JBS2qtN9IZpZNZaQMNlF7ixNu4VDzIltAqxoOMWDqbru88sSb38VeOYjxF1Bc6cuH66fOCj1nzeAkQ6UwFCJsVrPfGF1ZIEc10Fer~kKmSjOSNULkiGdg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Is_mammary_reconstruction_with_the_anatomical_Becker_expander_a_simple_procedure_Complications_and_hidden_problems_leading_to_secondary_surgical_procedures_A_follow_up_study","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[{"id":86445741,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445741/thumbnails/1.jpg","file_name":"j.bjps.2013.02.00420220525-1-m43ckz.pdf","download_url":"https://www.academia.edu/attachments/86445741/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Is_mammary_reconstruction_with_the_anato.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445741/j.bjps.2013.02.00420220525-1-m43ckz-libre.pdf?1653471925=\u0026response-content-disposition=attachment%3B+filename%3DIs_mammary_reconstruction_with_the_anato.pdf\u0026Expires=1732809418\u0026Signature=PDRS3h70itliNQzgAK7P7NwR5lKv6iAr~5kWJudVUIEFBpM082aLZXGZ1bTol-HYoIhONemInxcq1eN9b0LBGRMpw4jl6mxGqWuitD2QCN0oJ3NgHSn1K0sg3exjuo9VHhR57CH22n5Igb6HqKJlNpbgIcyWJ0wGTG6dBrAotSW0D14D~~2BiLDANZXCy4EoIjltRYwoukibx4ti5EAZ~APvhI63~HKf8JBS2qtN9IZpZNZaQMNlF7ixNu4VDzIltAqxoOMWDqbru88sSb38VeOYjxF1Bc6cuH66fOCj1nzeAkQ6UwFCJsVrPfGF1ZIEc10Fer~kKmSjOSNULkiGdg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":39516,"name":"Breast Implants","url":"https://www.academia.edu/Documents/in/Breast_Implants"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":715808,"name":"prosthesis Design","url":"https://www.academia.edu/Documents/in/prosthesis_Design"},{"id":2463621,"name":"Postoperative Complications","url":"https://www.academia.edu/Documents/in/Postoperative_Complications"},{"id":2482067,"name":"Reoperation","url":"https://www.academia.edu/Documents/in/Reoperation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879156"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879156/Toxic_epidermal_necrolysis_Lyells_disease_"><img alt="Research paper thumbnail of Toxic epidermal necrolysis (Lyell's disease)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879156/Toxic_epidermal_necrolysis_Lyells_disease_">Toxic epidermal necrolysis (Lyell's disease)</a></div><div class="wp-workCard_item"><span>Burns</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse drug react...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse drug reactions, characterized by a low incidence but high mortality, initially described as separate entities, but today considered variants of the same pathologic process and differing only for severity. The majority of cases appear to be related to idiosyncratic drug reactions. The drugs most commonly involved are: antibiotics such as sulfonamides, beta-lactam, tetracyclines and quinolones; anticonvulsants such as phenytoin, phenobarbital and carbamazapine; antiretroviral drugs; nonsteroidal anti-inflammatory drugs, allopurinol. There is common agreement to consider TEN as the manifestation of a disregulated immune reaction against epithelial cells. During the first stages of TEN, apoptosis mediates keratinocyte death and the pivotal role of Fas-FasL pathway activation during TEN is undoubted. T cell cytotoxicity, demonstrated during TEN, has been shown to be mediated by the perforin-granzyme pathway. It seems, also, clear that a peculiar cytokine pattern plays an important role in TEN pathogenesis. The cutaneous findings result in an acute macular erythematous rash with bullae. These lesions rapidly exhibit Nikolsky&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s sign and a separation of large sheets of epidermis from the dermis and a subsequent localised shedding develops rapidly, which can become very extensive. When feasible, admission in burn or intensive care unit, positioning the patients in air-fluidised beds, is universally considered crucial in TEN treatment. The prompt withdrawal of the suspected drug, fluid and electrolyte replacement and topical wound care are the first line of therapy. The use of corticosteroids has been abandoned and the role of immunosuppressants, despite some success, is not well defined and is not considered as a standard. A trial comparing thalidomide versus placebo in TEN patients was suspended because mortality rate increased in the treated group. Infliximab, a chimeric monoclonal antibody to TNF-alpha, has been administered to a patient, in single infusion, with a favourable outcome. Plasmapheresis is reported to lead to some success in TEN treatment, with improvement of clinical conditions and high percentage of survival. Different authors reported good results in terms of decreasing mortality and morbidity or improving clinical conditions of the use of human intravenous immunoglobulins (IVIGs). Regardless, the true utility of this treatment remains controversial. In 2005, the authors (ML and RC), dealing with a number of severe TEN cases, proposed a new protocol based on the combination of these last two techniques reporting their preliminary results in the treatment of severe TEN patients.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879156"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879156"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879156; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879156]").text(description); $(".js-view-count[data-work-id=79879156]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879156; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879156']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879156, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=79879156]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879156,"title":"Toxic epidermal necrolysis (Lyell's disease)","translated_title":"","metadata":{"abstract":"Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse drug reactions, characterized by a low incidence but high mortality, initially described as separate entities, but today considered variants of the same pathologic process and differing only for severity. The majority of cases appear to be related to idiosyncratic drug reactions. The drugs most commonly involved are: antibiotics such as sulfonamides, beta-lactam, tetracyclines and quinolones; anticonvulsants such as phenytoin, phenobarbital and carbamazapine; antiretroviral drugs; nonsteroidal anti-inflammatory drugs, allopurinol. There is common agreement to consider TEN as the manifestation of a disregulated immune reaction against epithelial cells. During the first stages of TEN, apoptosis mediates keratinocyte death and the pivotal role of Fas-FasL pathway activation during TEN is undoubted. T cell cytotoxicity, demonstrated during TEN, has been shown to be mediated by the perforin-granzyme pathway. It seems, also, clear that a peculiar cytokine pattern plays an important role in TEN pathogenesis. The cutaneous findings result in an acute macular erythematous rash with bullae. These lesions rapidly exhibit Nikolsky\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s sign and a separation of large sheets of epidermis from the dermis and a subsequent localised shedding develops rapidly, which can become very extensive. When feasible, admission in burn or intensive care unit, positioning the patients in air-fluidised beds, is universally considered crucial in TEN treatment. The prompt withdrawal of the suspected drug, fluid and electrolyte replacement and topical wound care are the first line of therapy. The use of corticosteroids has been abandoned and the role of immunosuppressants, despite some success, is not well defined and is not considered as a standard. A trial comparing thalidomide versus placebo in TEN patients was suspended because mortality rate increased in the treated group. Infliximab, a chimeric monoclonal antibody to TNF-alpha, has been administered to a patient, in single infusion, with a favourable outcome. Plasmapheresis is reported to lead to some success in TEN treatment, with improvement of clinical conditions and high percentage of survival. Different authors reported good results in terms of decreasing mortality and morbidity or improving clinical conditions of the use of human intravenous immunoglobulins (IVIGs). Regardless, the true utility of this treatment remains controversial. In 2005, the authors (ML and RC), dealing with a number of severe TEN cases, proposed a new protocol based on the combination of these last two techniques reporting their preliminary results in the treatment of severe TEN patients.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Burns"},"translated_abstract":"Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse drug reactions, characterized by a low incidence but high mortality, initially described as separate entities, but today considered variants of the same pathologic process and differing only for severity. The majority of cases appear to be related to idiosyncratic drug reactions. The drugs most commonly involved are: antibiotics such as sulfonamides, beta-lactam, tetracyclines and quinolones; anticonvulsants such as phenytoin, phenobarbital and carbamazapine; antiretroviral drugs; nonsteroidal anti-inflammatory drugs, allopurinol. There is common agreement to consider TEN as the manifestation of a disregulated immune reaction against epithelial cells. During the first stages of TEN, apoptosis mediates keratinocyte death and the pivotal role of Fas-FasL pathway activation during TEN is undoubted. T cell cytotoxicity, demonstrated during TEN, has been shown to be mediated by the perforin-granzyme pathway. It seems, also, clear that a peculiar cytokine pattern plays an important role in TEN pathogenesis. The cutaneous findings result in an acute macular erythematous rash with bullae. These lesions rapidly exhibit Nikolsky\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s sign and a separation of large sheets of epidermis from the dermis and a subsequent localised shedding develops rapidly, which can become very extensive. When feasible, admission in burn or intensive care unit, positioning the patients in air-fluidised beds, is universally considered crucial in TEN treatment. The prompt withdrawal of the suspected drug, fluid and electrolyte replacement and topical wound care are the first line of therapy. The use of corticosteroids has been abandoned and the role of immunosuppressants, despite some success, is not well defined and is not considered as a standard. A trial comparing thalidomide versus placebo in TEN patients was suspended because mortality rate increased in the treated group. Infliximab, a chimeric monoclonal antibody to TNF-alpha, has been administered to a patient, in single infusion, with a favourable outcome. Plasmapheresis is reported to lead to some success in TEN treatment, with improvement of clinical conditions and high percentage of survival. Different authors reported good results in terms of decreasing mortality and morbidity or improving clinical conditions of the use of human intravenous immunoglobulins (IVIGs). Regardless, the true utility of this treatment remains controversial. In 2005, the authors (ML and RC), dealing with a number of severe TEN cases, proposed a new protocol based on the combination of these last two techniques reporting their preliminary results in the treatment of severe TEN patients.","internal_url":"https://www.academia.edu/79879156/Toxic_epidermal_necrolysis_Lyells_disease_","translated_internal_url":"","created_at":"2022-05-25T02:30:40.701-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Toxic_epidermal_necrolysis_Lyells_disease_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":162553,"name":"Skin","url":"https://www.academia.edu/Documents/in/Skin"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":263029,"name":"Intensive Care Unit","url":"https://www.academia.edu/Documents/in/Intensive_Care_Unit"},{"id":284338,"name":"Stevens Johnson Syndrome","url":"https://www.academia.edu/Documents/in/Stevens_Johnson_Syndrome"},{"id":295466,"name":"Plasmapheresis","url":"https://www.academia.edu/Documents/in/Plasmapheresis"},{"id":367190,"name":"Burns","url":"https://www.academia.edu/Documents/in/Burns"},{"id":441679,"name":"Adverse Drug Reaction","url":"https://www.academia.edu/Documents/in/Adverse_Drug_Reaction"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":1177144,"name":"Epithelial Cell Biology","url":"https://www.academia.edu/Documents/in/Epithelial_Cell_Biology"},{"id":1436363,"name":"Toxic Epidermal Necrolysis","url":"https://www.academia.edu/Documents/in/Toxic_Epidermal_Necrolysis"},{"id":1489223,"name":"Intravenous Immunoglobulin","url":"https://www.academia.edu/Documents/in/Intravenous_Immunoglobulin"},{"id":1680434,"name":"Mortality rate","url":"https://www.academia.edu/Documents/in/Mortality_rate"},{"id":2562571,"name":"Immunosuppressive Agents","url":"https://www.academia.edu/Documents/in/Immunosuppressive_Agents"},{"id":3785460,"name":"Nonsteroidal Anti-inflammatory Drug","url":"https://www.academia.edu/Documents/in/Nonsteroidal_Anti_inflammatory_Drug"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879155"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879155/Ultrastructural_Anatomy_of_Contracted_Capsules_Around_Textured_Implants_in_Augmented_Breasts"><img alt="Research paper thumbnail of Ultrastructural Anatomy of Contracted Capsules Around Textured Implants in Augmented Breasts" class="work-thumbnail" src="https://attachments.academia-assets.com/86445781/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879155/Ultrastructural_Anatomy_of_Contracted_Capsules_Around_Textured_Implants_in_Augmented_Breasts">Ultrastructural Anatomy of Contracted Capsules Around Textured Implants in Augmented Breasts</a></div><div class="wp-workCard_item"><span>Annals of Plastic Surgery</span><span>, 2001</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="29c18cb0572c9c54d7fa585e35ed5c38" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445781,"asset_id":79879155,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445781/download_file?st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879155"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879155"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879155; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879155]").text(description); $(".js-view-count[data-work-id=79879155]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879155; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879155']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879155, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "29c18cb0572c9c54d7fa585e35ed5c38" } } $('.js-work-strip[data-work-id=79879155]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879155,"title":"Ultrastructural Anatomy of Contracted Capsules Around Textured Implants in Augmented Breasts","translated_title":"","metadata":{"publisher":"Ovid Technologies (Wolters Kluwer Health)","grobid_abstract":"The development of a capsule around an implant is part of the physiological response to a foreign body. Capsular contracture is the most specific and frustrating complication of augmentation mammaplasty, and a lot of studies have been devoted to it. The aim of the current study is to examine the fine architecture of the contracted capsule around textured implants in humans. Eight capsules from augmented and contracted breasts with gel-filled, textured-surface silicone implants were studied after standard preparation for light and scanning electron microscopy, and after partial digestion in sodium hydroxide. Two capsules from contracted breasts around smooth implants and two noncontracted capsules around textured implants were prepared and studied in the same fashion as controls. A multilayer structure of the contracted capsule was seen, and the architecture of the various layers is described. The inner surface presents irregular craterlike depressions. The arrangement of collagen fibers varies in capsule layers. The effect of a textured-surface implant on the mechanism of capsule contraction based on the observed capsular architecture is that only part of the capsule is effective mechanically in producing a contracting force. 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In the literature, this tumor has sometimes been described in proximity of breast implants (60 implant-related ALCL reported). In 2010, a patient who had undergone a right mastectomy and tissue expander/implant reconstruction for a ''ductal'' carcinoma 10 years before was referred to our unit for evaluation. On examination, an enlarged reconstructed right breast was found. The reconstructed breast did not show tenderness or signs of infection, ulceration, or breakdown. Mammograms and ultrasound scan did not suggest the presence of recurrent cancer, infection, deflation of the implant, or severe capsule contracture. The patient underwent mammary implant replacement. About 3 weeks after surgery, the patient came back to our unit for a new mild enlargement of the operated breast and the implant was removed. Three months later, the patient returned with a skin lesion in the right parasternal region. A radical excisional biopsy was performed under local anesthesia and the diagnosis of ALK-1-negative ALCL was finally made. The clinical and histological diagnosis of this disease is difficult","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Aesthetic Plastic 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permanence in breast reconstruction with Becker implant</a></div><div class="wp-workCard_item"><span>Journal of Plastic, Reconstructive & Aesthetic Surgery</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ea3249d11dec8c363179b392380fe791" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445664,"asset_id":79878979,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445664/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79878979"><a class="js-profile-work-strip-edit-button" 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href="https://www.academia.edu/73940909/CT_3D_reconstruction_of_the_arterial_network_of_anatomic_specimens_development_of_a_new_contrast_medium"><img alt="Research paper thumbnail of CT 3D reconstruction of the arterial network of anatomic specimens: development of a new contrast medium" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73940909/CT_3D_reconstruction_of_the_arterial_network_of_anatomic_specimens_development_of_a_new_contrast_medium">CT 3D reconstruction of the arterial network of anatomic specimens: development of a new contrast medium</a></div><div class="wp-workCard_item"><span>Italian Journal of Anatomy and Embryology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: The development of autologous tissue transfer techniques in plastic surgery has enc...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: The development of autologous tissue transfer techniques in plastic surgery has encouraged the research into cutaneous vascularization. This has resulted in the revival of interest in ancient techniques and in the development of new and more effective techniques. Riolano was the first to carry out studies of vascular injection [1]. Various substances have been used to fill blood vessels to facilitate dissection. The discovery of X rays revolutionized the field of vascular anatomy [2]. Barium sulfate was soon replaced by lead oxide as the standard contrast agent for injection studies. However, the toxicity of lead oxide limits the application of these techniques and exposes the operator to risks and raises the issue of its disposal. [3]. Two-dimensional contrast radiography has been the standard for investigating the vascular anatomy of surgical flaps. Today, new imaging techniques are available. Static CT angiography enables to evaluate vascular anatomy in 3D and high detail. The aim of this study is to propose a new contrast formula to visualize the vessels in TC 3D studies [4]. Materials and methods: A new contrast agent for CT injection studies has been developed. First the substance must be evaluated with standard radiography to confirm the X-ray blocking properties. Then, various anatomical, human and animal, specimens have been injected, and subjected to CT scan. The data have been processed with Osirix software for 3D reconstruction. Results: the radiopacity was confirmed. CT scan 3D reconstruction showed a good level of detail. Conclusion: our new formula appears to be effective. The radiopacity of the medium can be adapted to tissue characteristics. Our formula allows an easier dissection and a detailed reconstruction of the vessels. Moreover the final polymer is non-toxic.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73940909"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73940909"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73940909; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73940909]").text(description); $(".js-view-count[data-work-id=73940909]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73940909; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73940909']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73940909, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73940909]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73940909,"title":"CT 3D reconstruction of the arterial network of anatomic specimens: development of a new contrast medium","translated_title":"","metadata":{"abstract":"Introduction: The development of autologous tissue transfer techniques in plastic surgery has encouraged the research into cutaneous vascularization. This has resulted in the revival of interest in ancient techniques and in the development of new and more effective techniques. Riolano was the first to carry out studies of vascular injection [1]. Various substances have been used to fill blood vessels to facilitate dissection. The discovery of X rays revolutionized the field of vascular anatomy [2]. Barium sulfate was soon replaced by lead oxide as the standard contrast agent for injection studies. However, the toxicity of lead oxide limits the application of these techniques and exposes the operator to risks and raises the issue of its disposal. [3]. Two-dimensional contrast radiography has been the standard for investigating the vascular anatomy of surgical flaps. Today, new imaging techniques are available. Static CT angiography enables to evaluate vascular anatomy in 3D and high detail. The aim of this study is to propose a new contrast formula to visualize the vessels in TC 3D studies [4]. Materials and methods: A new contrast agent for CT injection studies has been developed. First the substance must be evaluated with standard radiography to confirm the X-ray blocking properties. Then, various anatomical, human and animal, specimens have been injected, and subjected to CT scan. The data have been processed with Osirix software for 3D reconstruction. Results: the radiopacity was confirmed. CT scan 3D reconstruction showed a good level of detail. Conclusion: our new formula appears to be effective. The radiopacity of the medium can be adapted to tissue characteristics. Our formula allows an easier dissection and a detailed reconstruction of the vessels. 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Two-dimensional contrast radiography has been the standard for investigating the vascular anatomy of surgical flaps. Today, new imaging techniques are available. Static CT angiography enables to evaluate vascular anatomy in 3D and high detail. The aim of this study is to propose a new contrast formula to visualize the vessels in TC 3D studies [4]. Materials and methods: A new contrast agent for CT injection studies has been developed. First the substance must be evaluated with standard radiography to confirm the X-ray blocking properties. Then, various anatomical, human and animal, specimens have been injected, and subjected to CT scan. The data have been processed with Osirix software for 3D reconstruction. Results: the radiopacity was confirmed. CT scan 3D reconstruction showed a good level of detail. Conclusion: our new formula appears to be effective. The radiopacity of the medium can be adapted to tissue characteristics. Our formula allows an easier dissection and a detailed reconstruction of the vessels. Moreover the final polymer is non-toxic.","internal_url":"https://www.academia.edu/73940909/CT_3D_reconstruction_of_the_arterial_network_of_anatomic_specimens_development_of_a_new_contrast_medium","translated_internal_url":"","created_at":"2022-03-17T04:19:34.311-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"CT_3D_reconstruction_of_the_arterial_network_of_anatomic_specimens_development_of_a_new_contrast_medium","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":171327,"name":"3-D Reconstruction","url":"https://www.academia.edu/Documents/in/3-D_Reconstruction"}],"urls":[{"id":18574558,"url":"http://www.fupress.net/index.php/ijae/article/download/11859/11271"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="67225795"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/67225795/I_carcinomi_in_situ_della_mammella_inquadramento_clinico_ed_attualit%C3%A0_terapeutiche_Commentary"><img alt="Research paper thumbnail of I carcinomi in situ della mammella : inquadramento clinico ed attualit脿 terapeutiche. Commentary" class="work-thumbnail" src="https://attachments.academia-assets.com/78122098/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/67225795/I_carcinomi_in_situ_della_mammella_inquadramento_clinico_ed_attualit%C3%A0_terapeutiche_Commentary">I carcinomi in situ della mammella : inquadramento clinico ed attualit脿 terapeutiche. Commentary</a></div><div class="wp-workCard_item"><span>Annali Italiani Di Chirurgia</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c19b013cd42c09a78c0f4eb6c37fd516" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":78122098,"asset_id":67225795,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/78122098/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="67225795"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="67225795"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 67225795; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=67225795]").text(description); $(".js-view-count[data-work-id=67225795]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 67225795; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='67225795']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 67225795, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c19b013cd42c09a78c0f4eb6c37fd516" } } $('.js-work-strip[data-work-id=67225795]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":67225795,"title":"I carcinomi in situ della mammella : inquadramento clinico ed attualit脿 terapeutiche. Commentary","translated_title":"","metadata":{"grobid_abstract":"In situ carcinomas of the breast: Clinic features and therapeutic strategies INTRODUCTION: Lobular and ductal carcinomas in situ of the breast (LCIS and DCIS) origin from the ductal-lobular unit of mammary gland, but they are characterized for different morphologic patterns and evolution. In 1980 they represent 1.4% of diagnosis in breast biopsy, less of 5% of carcinomas of the breast. Actually in 7.5% of breast biopsy an in situ carcinoma is recognized (approximating 40% of breast cancers). Our purpose is to evaluate the different available strategies in the clinic management of DCIS and LCIS and, in case of surgical treatment, which reconstructive approach obtains satisfactory breast conformation. MATERIALS AND METHODS: The study enclose 125 patients: 40 of them presented LCIS (32%) and 85 DCIS (68%). In 40 patients (32%) underposed to mastectomy was performed a reconstruction in cooperation with aesthetic surgeons. 35 of 40 women with LCIS are included in a follow-up programme, 5 of them had a bilateral mastectomy and reconstruction. RESULTS: No recurrences were observed in patients affected by LCIS. Six patients underposed to wide excision for DCIS developed local recurrence, treated by mastectomy. No recurrences were observed in patients treated initially with mastectomy. Some complications correlated to reconstruction were detected. CONCLUSIONS: One of most controversial sights in breast pathology is the understanding of biological meaning of CLIS: in facts CDIS can be considered a pre-invasive cancer, CLIS is reasonably considerable only a risk indicator for developing breast cancer but it isn't a pre-neoplastic lesion. Very important is the reconstruction of the breast to improve the quality life of patients.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Annali Italiani Di Chirurgia","grobid_abstract_attachment_id":78122098},"translated_abstract":null,"internal_url":"https://www.academia.edu/67225795/I_carcinomi_in_situ_della_mammella_inquadramento_clinico_ed_attualit%C3%A0_terapeutiche_Commentary","translated_internal_url":"","created_at":"2022-01-05T06:04:35.005-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":78122098,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/78122098/thumbnails/1.jpg","file_name":"003-012-min.pdf","download_url":"https://www.academia.edu/attachments/78122098/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"I_carcinomi_in_situ_della_mammella_inqua.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/78122098/003-012-min-libre.pdf?1641392155=\u0026response-content-disposition=attachment%3B+filename%3DI_carcinomi_in_situ_della_mammella_inqua.pdf\u0026Expires=1732809419\u0026Signature=LRPlbn1qSllXbACrSubKXzTRNZJFjN4paKY9jzeG8nAdXNtv1IGDniL-aY~B3fqOPe2wxmClDz1f91CuZSrdZaalgOXE2BbYgl9trw9~oh81WVP1AoDnSD6OKLjXUlQsm5JeTGpXHtkqCrnh~N6Bx9CFcOEVrvHZ5-PwS9JXybHca9YM6y3ZX~WIuDPOq8NlWBE-4HXUxhtDlozbItKB4B9ityy6zsueI9UTBoHuE5~nF9-Ak5LxPO1odn3ItivhrEkHSPYICkY65cMayUg65Oe6nuv5ruZwU~9E65eqKkrr1LPgx8e~nB-Grv0yoTzdNJOAIxBQfytUvQXyzuL3kQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"I_carcinomi_in_situ_della_mammella_inquadramento_clinico_ed_attualit脿_terapeutiche_Commentary","translated_slug":"","page_count":10,"language":"it","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[{"id":78122098,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/78122098/thumbnails/1.jpg","file_name":"003-012-min.pdf","download_url":"https://www.academia.edu/attachments/78122098/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"I_carcinomi_in_situ_della_mammella_inqua.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/78122098/003-012-min-libre.pdf?1641392155=\u0026response-content-disposition=attachment%3B+filename%3DI_carcinomi_in_situ_della_mammella_inqua.pdf\u0026Expires=1732809419\u0026Signature=LRPlbn1qSllXbACrSubKXzTRNZJFjN4paKY9jzeG8nAdXNtv1IGDniL-aY~B3fqOPe2wxmClDz1f91CuZSrdZaalgOXE2BbYgl9trw9~oh81WVP1AoDnSD6OKLjXUlQsm5JeTGpXHtkqCrnh~N6Bx9CFcOEVrvHZ5-PwS9JXybHca9YM6y3ZX~WIuDPOq8NlWBE-4HXUxhtDlozbItKB4B9ityy6zsueI9UTBoHuE5~nF9-Ak5LxPO1odn3ItivhrEkHSPYICkY65cMayUg65Oe6nuv5ruZwU~9E65eqKkrr1LPgx8e~nB-Grv0yoTzdNJOAIxBQfytUvQXyzuL3kQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[{"id":16108944,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=17964435"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="67225794"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/67225794/A_theoretical_model_describing_arterial_flow_in_the_DIEP_flap_related_to_number_and_size_of_perforator_vessels"><img alt="Research paper thumbnail of A theoretical model describing arterial flow in the DIEP flap related to number and size of perforator vessels" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/67225794/A_theoretical_model_describing_arterial_flow_in_the_DIEP_flap_related_to_number_and_size_of_perforator_vessels">A theoretical model describing arterial flow in the DIEP flap related to number and size of perforator vessels</a></div><div class="wp-workCard_item"><span>Journal of Plastic, Reconstructive & Aesthetic Surgery</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The deep inferior epigastric perforator flap is rapidly becoming a more widely employed method of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The deep inferior epigastric perforator flap is rapidly becoming a more widely employed method of autologous breast reconstruction. The technical considerations involved in the execution of the flap are many and include the selection of perforators to be incorporated in the flap. We attempt to give a mathematical explanation, based on the physics of flow through vessels and the properties of circuits with multiple resistances in parallel, for the clinical observations which have been arrived at through clinical experience. We compare the system of perforators to a circuit with multiple resistances in parallel. Each of these resistances represents a perforator vessel. In the event that there is only one perforator vessel, this simplifies to a single resistance in series with the capillary bed perfusing the flap. The flow through the flap is optimized by incorporation of the largest diameter perforator. Inclusion of other smaller perforators in addition to the largest diameter perforator will reduce the overall resistance, but this reduction in resistance is dependent on the diameter of the additional perforator and may not be worth the additional trauma of dissection and increased operative time. Incorporating several smaller perforators at the expense of excluding the largest diameter perforator appears to increase the overall resistance, unless the smaller perforators are only slightly smaller. We conclude that the best perfused flap involves use of the largest diameter vessel, that although adding additional perforators will decrease the resistance and increase flow, the magnitude of the benefit depends largely on the calibre of the additional perforator, and that this benefit needs to be weighed against the downside of increased muscle and facial trauma.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="67225794"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="67225794"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 67225794; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=67225794]").text(description); $(".js-view-count[data-work-id=67225794]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 67225794; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='67225794']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 67225794, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=67225794]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":67225794,"title":"A theoretical model describing arterial flow in the DIEP flap related to number and size of perforator vessels","translated_title":"","metadata":{"abstract":"The deep inferior epigastric perforator flap is rapidly becoming a more widely employed method of autologous breast reconstruction. The technical considerations involved in the execution of the flap are many and include the selection of perforators to be incorporated in the flap. We attempt to give a mathematical explanation, based on the physics of flow through vessels and the properties of circuits with multiple resistances in parallel, for the clinical observations which have been arrived at through clinical experience. We compare the system of perforators to a circuit with multiple resistances in parallel. Each of these resistances represents a perforator vessel. In the event that there is only one perforator vessel, this simplifies to a single resistance in series with the capillary bed perfusing the flap. The flow through the flap is optimized by incorporation of the largest diameter perforator. Inclusion of other smaller perforators in addition to the largest diameter perforator will reduce the overall resistance, but this reduction in resistance is dependent on the diameter of the additional perforator and may not be worth the additional trauma of dissection and increased operative time. Incorporating several smaller perforators at the expense of excluding the largest diameter perforator appears to increase the overall resistance, unless the smaller perforators are only slightly smaller. We conclude that the best perfused flap involves use of the largest diameter vessel, that although adding additional perforators will decrease the resistance and increase flow, the magnitude of the benefit depends largely on the calibre of the additional perforator, and that this benefit needs to be weighed against the downside of increased muscle and facial trauma.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Journal of Plastic, Reconstructive \u0026 Aesthetic Surgery"},"translated_abstract":"The deep inferior epigastric perforator flap is rapidly becoming a more widely employed method of autologous breast reconstruction. The technical considerations involved in the execution of the flap are many and include the selection of perforators to be incorporated in the flap. We attempt to give a mathematical explanation, based on the physics of flow through vessels and the properties of circuits with multiple resistances in parallel, for the clinical observations which have been arrived at through clinical experience. We compare the system of perforators to a circuit with multiple resistances in parallel. Each of these resistances represents a perforator vessel. In the event that there is only one perforator vessel, this simplifies to a single resistance in series with the capillary bed perfusing the flap. The flow through the flap is optimized by incorporation of the largest diameter perforator. Inclusion of other smaller perforators in addition to the largest diameter perforator will reduce the overall resistance, but this reduction in resistance is dependent on the diameter of the additional perforator and may not be worth the additional trauma of dissection and increased operative time. Incorporating several smaller perforators at the expense of excluding the largest diameter perforator appears to increase the overall resistance, unless the smaller perforators are only slightly smaller. We conclude that the best perfused flap involves use of the largest diameter vessel, that although adding additional perforators will decrease the resistance and increase flow, the magnitude of the benefit depends largely on the calibre of the additional perforator, and that this benefit needs to be weighed against the downside of increased muscle and facial trauma.","internal_url":"https://www.academia.edu/67225794/A_theoretical_model_describing_arterial_flow_in_the_DIEP_flap_related_to_number_and_size_of_perforator_vessels","translated_internal_url":"","created_at":"2022-01-05T06:04:34.800-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"A_theoretical_model_describing_arterial_flow_in_the_DIEP_flap_related_to_number_and_size_of_perforator_vessels","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":8017,"name":"Microcirculation","url":"https://www.academia.edu/Documents/in/Microcirculation"},{"id":8942,"name":"Treatment","url":"https://www.academia.edu/Documents/in/Treatment"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":413301,"name":"Perforation","url":"https://www.academia.edu/Documents/in/Perforation"},{"id":426588,"name":"Blood Flow","url":"https://www.academia.edu/Documents/in/Blood_Flow"},{"id":492043,"name":"Size","url":"https://www.academia.edu/Documents/in/Size"},{"id":1154248,"name":"Theoretical Model","url":"https://www.academia.edu/Documents/in/Theoretical_Model"},{"id":1969879,"name":"Vascular Resistance","url":"https://www.academia.edu/Documents/in/Vascular_Resistance"},{"id":3724721,"name":"Surgical Flaps","url":"https://www.academia.edu/Documents/in/Surgical_Flaps"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="67225793"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/67225793/A_Theoretical_Model_Describing_Arterial_Flow_In_the_DIEP_Flap_Related_to_Number_and_Size_of_Perforator_Vessels"><img alt="Research paper thumbnail of A Theoretical Model Describing Arterial Flow In the DIEP Flap Related to Number and Size of Perforator Vessels" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/67225793/A_Theoretical_Model_Describing_Arterial_Flow_In_the_DIEP_Flap_Related_to_Number_and_Size_of_Perforator_Vessels">A Theoretical Model Describing Arterial Flow In the DIEP Flap Related to Number and Size of Perforator Vessels</a></div><div class="wp-workCard_item"><span>J Plast Reconstr Aesthet Surg</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The deep inferior epigastric perforator flap is rapidly becoming a more widely employed method of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The deep inferior epigastric perforator flap is rapidly becoming a more widely employed method of autologous breast reconstruction. The technical considerations involved in the execution of the flap are many and include the selection of perforators to be incorporated in the flap. We attempt to give a mathematical explanation, based on the physics of flow through vessels and the properties of circuits with multiple resistances in parallel, for the clinical observations which have been arrived at through clinical experience. We compare the system of perforators to a circuit with multiple resistances in parallel. Each of these resistances represents a perforator vessel. In the event that there is only one perforator vessel, this simplifies to a single resistance in series with the capillary bed perfusing the flap. The flow through the flap is optimized by incorporation of the largest diameter perforator. Inclusion of other smaller perforators in addition to the largest diameter perforator will reduce the overall resistance, but this reduction in resistance is dependent on the diameter of the additional perforator and may not be worth the additional trauma of dissection and increased operative time. Incorporating several smaller perforators at the expense of excluding the largest diameter perforator appears to increase the overall resistance, unless the smaller perforators are only slightly smaller. We conclude that the best perfused flap involves use of the largest diameter vessel, that although adding additional perforators will decrease the resistance and increase flow, the magnitude of the benefit depends largely on the calibre of the additional perforator, and that this benefit needs to be weighed against the downside of increased muscle and facial trauma.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="67225793"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="67225793"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 67225793; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=67225793]").text(description); $(".js-view-count[data-work-id=67225793]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 67225793; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='67225793']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 67225793, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=67225793]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":67225793,"title":"A Theoretical Model Describing Arterial Flow In the DIEP Flap Related to Number and Size of Perforator Vessels","translated_title":"","metadata":{"abstract":"The deep inferior epigastric perforator flap is rapidly becoming a more widely employed method of autologous breast reconstruction. 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Inclusion of other smaller perforators in addition to the largest diameter perforator will reduce the overall resistance, but this reduction in resistance is dependent on the diameter of the additional perforator and may not be worth the additional trauma of dissection and increased operative time. Incorporating several smaller perforators at the expense of excluding the largest diameter perforator appears to increase the overall resistance, unless the smaller perforators are only slightly smaller. 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We attempt to give a mathematical explanation, based on the physics of flow through vessels and the properties of circuits with multiple resistances in parallel, for the clinical observations which have been arrived at through clinical experience. We compare the system of perforators to a circuit with multiple resistances in parallel. Each of these resistances represents a perforator vessel. In the event that there is only one perforator vessel, this simplifies to a single resistance in series with the capillary bed perfusing the flap. The flow through the flap is optimized by incorporation of the largest diameter perforator. Inclusion of other smaller perforators in addition to the largest diameter perforator will reduce the overall resistance, but this reduction in resistance is dependent on the diameter of the additional perforator and may not be worth the additional trauma of dissection and increased operative time. Incorporating several smaller perforators at the expense of excluding the largest diameter perforator appears to increase the overall resistance, unless the smaller perforators are only slightly smaller. 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Personal experience on eleven years","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1999,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/67225543/Failures_in_microsurgery_complications_or_faults_Personal_experience_on_eleven_years","translated_internal_url":"","created_at":"2022-01-05T06:02:48.397-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Failures_in_microsurgery_complications_or_faults_Personal_experience_on_eleven_years","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="5551641" id="papers"><div class="js-work-strip profile--work_container" data-work-id="79879170"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879170/Case_Report_Reconstruction_of_Traumatic_Defect_of_the_Lower_Third_of_the_Leg_Using_a_Combined_Therapy_Negative_Pressure_Wound_Therapy_Acellular_Dermal_Matrix_and_Skin_Graft"><img alt="Research paper thumbnail of Case Report Reconstruction of Traumatic Defect of the Lower Third of the Leg Using a Combined Therapy: Negative Pressure Wound Therapy, Acellular Dermal Matrix, and Skin Graft" class="work-thumbnail" src="https://attachments.academia-assets.com/86445735/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879170/Case_Report_Reconstruction_of_Traumatic_Defect_of_the_Lower_Third_of_the_Leg_Using_a_Combined_Therapy_Negative_Pressure_Wound_Therapy_Acellular_Dermal_Matrix_and_Skin_Graft">Case Report Reconstruction of Traumatic Defect of the Lower Third of the Leg Using a Combined Therapy: Negative Pressure Wound Therapy, Acellular Dermal Matrix, and Skin Graft</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The reconstruction of lower third of the leg is one of the most challenging problems for plastic ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The reconstruction of lower third of the leg is one of the most challenging problems for plastic and reconstructive surgeons and current approaches are still disappointing. We show an easy option to obtain a coverage of traumatic pretibial defects with good aesthetic and functional results: the association of negative pressure wound therapy, acellular dermal matrix, and skin graft. The choice of this combined therapy avoids other surgical procedures such as local perforator flaps and free flaps that require more operating time, special equipment, and adequate training.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f2058b3731f7d140ee6481210bde9244" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445735,"asset_id":79879170,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445735/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879170"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879170"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879170; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879170]").text(description); $(".js-view-count[data-work-id=79879170]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879170; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879170']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879170, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f2058b3731f7d140ee6481210bde9244" } } $('.js-work-strip[data-work-id=79879170]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879170,"title":"Case Report Reconstruction of Traumatic Defect of the Lower Third of the Leg Using a Combined Therapy: Negative Pressure Wound Therapy, Acellular Dermal Matrix, and Skin Graft","translated_title":"","metadata":{"abstract":"The reconstruction of lower third of the leg is one of the most challenging problems for plastic and reconstructive surgeons and current approaches are still disappointing. 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The choice of this combined therapy avoids other surgical procedures such as local perforator flaps and free flaps that require more operating time, special equipment, and adequate training.","internal_url":"https://www.academia.edu/79879170/Case_Report_Reconstruction_of_Traumatic_Defect_of_the_Lower_Third_of_the_Leg_Using_a_Combined_Therapy_Negative_Pressure_Wound_Therapy_Acellular_Dermal_Matrix_and_Skin_Graft","translated_internal_url":"","created_at":"2022-05-25T02:30:42.074-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86445735,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445735/thumbnails/1.jpg","file_name":"783812.pdf","download_url":"https://www.academia.edu/attachments/86445735/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Case_Report_Reconstruction_of_Traumatic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445735/783812-libre.pdf?1653471926=\u0026response-content-disposition=attachment%3B+filename%3DCase_Report_Reconstruction_of_Traumatic.pdf\u0026Expires=1732809418\u0026Signature=hRWvEj478cAyEzJrJu73RSdCYASKem1Xzfwvb5F97KxPAHgCR4QGXJG7b3E29C2S~psQzhnbUznNR6XYor70vxAy30s-gzm47xjBbwSA-RfflK7eKhw0wruV5gSWp4yzs026NDb3oPw0FgMzO0Gu3ONjwLYKGamCogB7h6IMYIjYXqBTDZGsS89OLtm6cqLHepAqCHlguxH52szKB6lA5oJzLOApXQT9khdtigmWNwft9YMWBI2O-Rbjkz~HQJpHk8LNZlGWa4FLFYJRd6NDA6qIlG4papkQ51Klj-rCsaJ8aoAsn3CkfwsRaSBO3bzK7PC17Eo9WCwL6IL567w5dw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Case_Report_Reconstruction_of_Traumatic_Defect_of_the_Lower_Third_of_the_Leg_Using_a_Combined_Therapy_Negative_Pressure_Wound_Therapy_Acellular_Dermal_Matrix_and_Skin_Graft","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[{"id":86445735,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445735/thumbnails/1.jpg","file_name":"783812.pdf","download_url":"https://www.academia.edu/attachments/86445735/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Case_Report_Reconstruction_of_Traumatic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445735/783812-libre.pdf?1653471926=\u0026response-content-disposition=attachment%3B+filename%3DCase_Report_Reconstruction_of_Traumatic.pdf\u0026Expires=1732809418\u0026Signature=hRWvEj478cAyEzJrJu73RSdCYASKem1Xzfwvb5F97KxPAHgCR4QGXJG7b3E29C2S~psQzhnbUznNR6XYor70vxAy30s-gzm47xjBbwSA-RfflK7eKhw0wruV5gSWp4yzs026NDb3oPw0FgMzO0Gu3ONjwLYKGamCogB7h6IMYIjYXqBTDZGsS89OLtm6cqLHepAqCHlguxH52szKB6lA5oJzLOApXQT9khdtigmWNwft9YMWBI2O-Rbjkz~HQJpHk8LNZlGWa4FLFYJRd6NDA6qIlG4papkQ51Klj-rCsaJ8aoAsn3CkfwsRaSBO3bzK7PC17Eo9WCwL6IL567w5dw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":20760591,"url":"http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1077.8419\u0026rep=rep1\u0026type=pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879168"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879168/Complications_after_breast_augmentation_with_hyaluronic_acid_a_case_report"><img alt="Research paper thumbnail of Complications after breast augmentation with hyaluronic acid: a case report" class="work-thumbnail" src="https://attachments.academia-assets.com/86445677/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879168/Complications_after_breast_augmentation_with_hyaluronic_acid_a_case_report">Complications after breast augmentation with hyaluronic acid: a case report</a></div><div class="wp-workCard_item"><span>Gland Surgery</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8797d9ad8bc166d3350b0183b990e5ef" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445677,"asset_id":79879168,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445677/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879168"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879168"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879168; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879168]").text(description); $(".js-view-count[data-work-id=79879168]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879168; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879168']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879168, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Over time, various techniques of breast augmentation have been described, both through the use of alloplastic materials and autologous tissues: implants, fat grafting, flap surgery, and injectable fillers. According to the international current trend to perform minimally invasive procedure, injectable fillers have progressively increased their uses and notoriety in aesthetic medicine. Among the various available products, hyaluronic acid is likely to be the most popular synthetic filler all over the world. Nowadays many brands are on the market and this paper focuses on Macrolane which is a NASHA-based (stabilized hyaluronic acid of non-animal origin) filler. However, although highly biocompatible, as any material, foreign to our body, also hyaluronic acid fillers undergo a process of degradation and disposal. In our work, we report the first case in literature of migration of Macrolane in an axillary lymph node in a 45-year-old woman three years after injection for breast augmentation and its related management. The aim of the paper is to discuss and underline further complications and their treatment besides the ones already described in literature in order to provide a deeper knowledge concerning the use and the side effects of injectable fillers in aesthetic medicine.","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Gland Surgery","grobid_abstract_attachment_id":86445677},"translated_abstract":null,"internal_url":"https://www.academia.edu/79879168/Complications_after_breast_augmentation_with_hyaluronic_acid_a_case_report","translated_internal_url":"","created_at":"2022-05-25T02:30:41.854-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86445677,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445677/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/86445677/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Complications_after_breast_augmentation.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445677/pdf-libre.pdf?1653471938=\u0026response-content-disposition=attachment%3B+filename%3DComplications_after_breast_augmentation.pdf\u0026Expires=1732809418\u0026Signature=JEpl2Sy5gTZXtnQgiURMzT30ri3Rh1YXEIvL0YmW8TRUl41jnOt~HhRkq2FkNxskpeHRl~J~ApI0c-6BnwTyR3oJssj8YzfiQ7vft~C8AjiOSQ0gUAC-hg9EZZueORx5FwshW5GGuNEIF7HplbR4hx42X8n6a3KJyQata-NRnS6VfLgHbq3S~mtb4bDBicPVSZiMaD8lxtZXsE6I0qqFvDqIN~b-pcfjY3MfdzZt1AyeI3rL6g1MCQwlhjP4tBMCuKlqa7g78ludeVuA7mlB5mt~3oJWeixs7xcK72HNpnpRy7256X1Jq31QT067OWom34Vamync1kMe4Cck3MHDKA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Complications_after_breast_augmentation_with_hyaluronic_acid_a_case_report","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[{"id":86445677,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445677/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/86445677/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Complications_after_breast_augmentation.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445677/pdf-libre.pdf?1653471938=\u0026response-content-disposition=attachment%3B+filename%3DComplications_after_breast_augmentation.pdf\u0026Expires=1732809418\u0026Signature=JEpl2Sy5gTZXtnQgiURMzT30ri3Rh1YXEIvL0YmW8TRUl41jnOt~HhRkq2FkNxskpeHRl~J~ApI0c-6BnwTyR3oJssj8YzfiQ7vft~C8AjiOSQ0gUAC-hg9EZZueORx5FwshW5GGuNEIF7HplbR4hx42X8n6a3KJyQata-NRnS6VfLgHbq3S~mtb4bDBicPVSZiMaD8lxtZXsE6I0qqFvDqIN~b-pcfjY3MfdzZt1AyeI3rL6g1MCQwlhjP4tBMCuKlqa7g78ludeVuA7mlB5mt~3oJWeixs7xcK72HNpnpRy7256X1Jq31QT067OWom34Vamync1kMe4Cck3MHDKA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":86445676,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445676/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/86445676/download_file","bulk_download_file_name":"Complications_after_breast_augmentation.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445676/pdf-libre.pdf?1653471943=\u0026response-content-disposition=attachment%3B+filename%3DComplications_after_breast_augmentation.pdf\u0026Expires=1732809418\u0026Signature=XT8mTXwsPUhoM9a1jSfwTXisOERU0nvJGLxFizfVwaku7R26BLHzaK9D67i7w-I9E1o6t0YIBE0IpTzPk4mS1ndO5scokHITiCLed-AiBK7RuMXOAOD8LiVRYfslGT3bjJc-9X5HeCgq0IZdbralN69~0dSnlRPtq0vT-tybKq5GOM5GSCRVMrIv9M5lL0Hvly2vPxjkMc6WRYzHKthS6CzpGn6R~LD5iDjaX6EjZ7z0JVoWkHPiksCHcwdGl6E86g0ccQ9wLR9cGkenwjU5RPdTxc12fGneAWt-MkKU42oUdcNkgGeG3KVNQhm9eJcRIfZVJ29WwlntgiFaROPNIw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"}],"urls":[{"id":20760590,"url":"http://gs.amegroups.com/article/download/54727/pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879166"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879166/Low_Versus_High_Vacuum_Suction_Drainage_of_the_Submuscular_Pocket_in_Primary_Breast_Reconstruction_A_Retrospective_Study"><img alt="Research paper thumbnail of Low Versus High Vacuum Suction Drainage of the Submuscular Pocket in Primary Breast Reconstruction: A Retrospective Study" class="work-thumbnail" src="https://attachments.academia-assets.com/86445736/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879166/Low_Versus_High_Vacuum_Suction_Drainage_of_the_Submuscular_Pocket_in_Primary_Breast_Reconstruction_A_Retrospective_Study">Low Versus High Vacuum Suction Drainage of the Submuscular Pocket in Primary Breast Reconstruction: A Retrospective Study</a></div><div class="wp-workCard_item"><span>Annals of plastic surgery</span><span>, Jan 31, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Placement of suction drainage in submuscular pockets is routinely performed in breast reconstruct...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Placement of suction drainage in submuscular pockets is routinely performed in breast reconstruction. Days of drain permanence (DDP) are associated with hospital stay and related health care costs. The aims of this study are to retrospectively compare data related to DDP and total drainage volume between high and low vacuum suction drainage groups and to identify correlations with patient or surgery-related factors. We retrospectively analyzed data of 100 patients undergoing immediate or delayed breast reconstruction with expanders and implants. We considered 2 groups depending on suction pressure applied by 2 different surgical teams: group A (number, 50 patients) with high vacuum suction and group B (number, 50 patients) with low vacuum suction. Days of drain permanence was not significantly different between group A and group B (P = 0.451). The same was found for total drainage volume (P = 0.183). The distribution of DDP was statistically different only between patients with or w...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="349d2889ebb76b946a0c1fcec163f1fa" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445736,"asset_id":79879166,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445736/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879166"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879166"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879166; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879166]").text(description); $(".js-view-count[data-work-id=79879166]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879166; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879166']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879166, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "349d2889ebb76b946a0c1fcec163f1fa" } } $('.js-work-strip[data-work-id=79879166]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879166,"title":"Low Versus High Vacuum Suction Drainage of the Submuscular Pocket in Primary Breast Reconstruction: A Retrospective Study","translated_title":"","metadata":{"abstract":"Placement of suction drainage in submuscular pockets is routinely performed in breast reconstruction. Days of drain permanence (DDP) are associated with hospital stay and related health care costs. The aims of this study are to retrospectively compare data related to DDP and total drainage volume between high and low vacuum suction drainage groups and to identify correlations with patient or surgery-related factors. We retrospectively analyzed data of 100 patients undergoing immediate or delayed breast reconstruction with expanders and implants. We considered 2 groups depending on suction pressure applied by 2 different surgical teams: group A (number, 50 patients) with high vacuum suction and group B (number, 50 patients) with low vacuum suction. Days of drain permanence was not significantly different between group A and group B (P = 0.451). The same was found for total drainage volume (P = 0.183). The distribution of DDP was statistically different only between patients with or w...","ai_title_tag":"High vs Low Vacuum Drainage in Breast Reconstruction Outcomes","publication_date":{"day":31,"month":1,"year":2017,"errors":{}},"publication_name":"Annals of plastic surgery"},"translated_abstract":"Placement of suction drainage in submuscular pockets is routinely performed in breast reconstruction. Days of drain permanence (DDP) are associated with hospital stay and related health care costs. The aims of this study are to retrospectively compare data related to DDP and total drainage volume between high and low vacuum suction drainage groups and to identify correlations with patient or surgery-related factors. We retrospectively analyzed data of 100 patients undergoing immediate or delayed breast reconstruction with expanders and implants. We considered 2 groups depending on suction pressure applied by 2 different surgical teams: group A (number, 50 patients) with high vacuum suction and group B (number, 50 patients) with low vacuum suction. Days of drain permanence was not significantly different between group A and group B (P = 0.451). The same was found for total drainage volume (P = 0.183). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879164"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879164/Expression_of_the_anti_apoptotic_BAG3_protein_in_leg_venous_ulcerative_tissues"><img alt="Research paper thumbnail of Expression of the anti-apoptotic BAG3 protein in leg venous ulcerative tissues" class="work-thumbnail" src="https://attachments.academia-assets.com/86445733/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879164/Expression_of_the_anti_apoptotic_BAG3_protein_in_leg_venous_ulcerative_tissues">Expression of the anti-apoptotic BAG3 protein in leg venous ulcerative tissues</a></div><div class="wp-workCard_item"><span>Cell Death Discovery</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="273d9ad2a1683a08eab475af96eabb1b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445733,"asset_id":79879164,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445733/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879164"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879164"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879164; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879161"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879161/The_localization_of_the_distal_perforators_of_posterior_tibial_artery_a_cadaveric_study_for_the_correct_planning_of_medial_adipofascial_flaps"><img alt="Research paper thumbnail of The localization of the distal perforators of posterior tibial artery: a cadaveric study for the correct planning of medial adipofascial flaps" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879161/The_localization_of_the_distal_perforators_of_posterior_tibial_artery_a_cadaveric_study_for_the_correct_planning_of_medial_adipofascial_flaps">The localization of the distal perforators of posterior tibial artery: a cadaveric study for the correct planning of medial adipofascial flaps</a></div><div class="wp-workCard_item"><span>Surgical and Radiologic Anatomy</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The adipofascial flap, introduced by Lin in 1994, has many advantages compared to fasciocutaneous...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The adipofascial flap, introduced by Lin in 1994, has many advantages compared to fasciocutaneous or free flaps. Its dissection is relatively easy and fast with low donor-site morbidity, and it does not alter the shape of the leg. The aim of this dissection study is to evaluate the anatomic localization of the most distal perforator of the posterior tibial vessels to provide an anatomical rationale for the safe harvesting of distally based medial adipofascial flaps of the leg. 30 Lower limbs from 15 cadavers were used for this study. The most distal perforator from posterior tibial perforator artery, accompanied by at least one vein, was identified and its distance from the medial malleolus was noted. A distal perforator was found in all specimens; the mean caliber was 0.77 mm. In all cases, the perforator artery passed in the septum between flexor hallucis longus m. and flexor digitorum longus m. and was accompanied by two veins. In our series, the distance between the lowest perforator and the medial malleolus ranged from 3.5 to 8.2 cm. The median was 6.75 cm, the 5th percentile 4 cm and the 95th percentile 8.1 cm. The mean distance of the perforator from the medial tibial border was 1.23 cm. The mean ratio between the distance of perforator from the medial malleolus and the total leg length was 21%. Compared to all previous researches, our study has found more distal perforators from posterior tibial perforator artery. This fact may have important clinical consequences, because the anteromedial adipofascial flap would cover more distal soft tissue defects. Moreover, our data suggest some safety parameters to make the rising of a medial adipofascial leg flap safer in surgical practice.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879161"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879161"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879161; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879161]").text(description); $(".js-view-count[data-work-id=79879161]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879161; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879161']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879161, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=79879161]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879161,"title":"The localization of the distal perforators of posterior tibial artery: a cadaveric study for the correct planning of medial adipofascial flaps","translated_title":"","metadata":{"abstract":"The adipofascial flap, introduced by Lin in 1994, has many advantages compared to fasciocutaneous or free flaps. Its dissection is relatively easy and fast with low donor-site morbidity, and it does not alter the shape of the leg. The aim of this dissection study is to evaluate the anatomic localization of the most distal perforator of the posterior tibial vessels to provide an anatomical rationale for the safe harvesting of distally based medial adipofascial flaps of the leg. 30 Lower limbs from 15 cadavers were used for this study. The most distal perforator from posterior tibial perforator artery, accompanied by at least one vein, was identified and its distance from the medial malleolus was noted. A distal perforator was found in all specimens; the mean caliber was 0.77 mm. In all cases, the perforator artery passed in the septum between flexor hallucis longus m. and flexor digitorum longus m. and was accompanied by two veins. In our series, the distance between the lowest perforator and the medial malleolus ranged from 3.5 to 8.2 cm. The median was 6.75 cm, the 5th percentile 4 cm and the 95th percentile 8.1 cm. The mean distance of the perforator from the medial tibial border was 1.23 cm. The mean ratio between the distance of perforator from the medial malleolus and the total leg length was 21%. Compared to all previous researches, our study has found more distal perforators from posterior tibial perforator artery. This fact may have important clinical consequences, because the anteromedial adipofascial flap would cover more distal soft tissue defects. Moreover, our data suggest some safety parameters to make the rising of a medial adipofascial leg flap safer in surgical practice.","publisher":"Springer Science and Business Media LLC","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Surgical and Radiologic Anatomy"},"translated_abstract":"The adipofascial flap, introduced by Lin in 1994, has many advantages compared to fasciocutaneous or free flaps. Its dissection is relatively easy and fast with low donor-site morbidity, and it does not alter the shape of the leg. The aim of this dissection study is to evaluate the anatomic localization of the most distal perforator of the posterior tibial vessels to provide an anatomical rationale for the safe harvesting of distally based medial adipofascial flaps of the leg. 30 Lower limbs from 15 cadavers were used for this study. The most distal perforator from posterior tibial perforator artery, accompanied by at least one vein, was identified and its distance from the medial malleolus was noted. A distal perforator was found in all specimens; the mean caliber was 0.77 mm. In all cases, the perforator artery passed in the septum between flexor hallucis longus m. and flexor digitorum longus m. and was accompanied by two veins. In our series, the distance between the lowest perforator and the medial malleolus ranged from 3.5 to 8.2 cm. The median was 6.75 cm, the 5th percentile 4 cm and the 95th percentile 8.1 cm. The mean distance of the perforator from the medial tibial border was 1.23 cm. The mean ratio between the distance of perforator from the medial malleolus and the total leg length was 21%. Compared to all previous researches, our study has found more distal perforators from posterior tibial perforator artery. This fact may have important clinical consequences, because the anteromedial adipofascial flap would cover more distal soft tissue defects. Moreover, our data suggest some safety parameters to make the rising of a medial adipofascial leg flap safer in surgical practice.","internal_url":"https://www.academia.edu/79879161/The_localization_of_the_distal_perforators_of_posterior_tibial_artery_a_cadaveric_study_for_the_correct_planning_of_medial_adipofascial_flaps","translated_internal_url":"","created_at":"2022-05-25T02:30:41.340-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_localization_of_the_distal_perforators_of_posterior_tibial_artery_a_cadaveric_study_for_the_correct_planning_of_medial_adipofascial_flaps","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":1000427,"name":"Reference Values","url":"https://www.academia.edu/Documents/in/Reference_Values"}],"urls":[{"id":20760588,"url":"http://link.springer.com/content/pdf/10.1007/s00276-014-1275-9.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879159"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879159/Transverse_Upper_Gracilis_Flap_with_Implant_In_Postmastectomy_Breast_Reconstruction_a_Case_Report"><img alt="Research paper thumbnail of Transverse Upper Gracilis Flap with Implant In Postmastectomy Breast Reconstruction: a Case Report" class="work-thumbnail" src="https://attachments.academia-assets.com/86445737/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879159/Transverse_Upper_Gracilis_Flap_with_Implant_In_Postmastectomy_Breast_Reconstruction_a_Case_Report">Transverse Upper Gracilis Flap with Implant In Postmastectomy Breast Reconstruction: a Case Report</a></div><div class="wp-workCard_item"><span>Microsurgery</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9cd080893f3f30bb0d9e8c5e1b19f0fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445737,"asset_id":79879159,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445737/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879159"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879159"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879159; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879159]").text(description); $(".js-view-count[data-work-id=79879159]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879159; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879159']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879159, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9cd080893f3f30bb0d9e8c5e1b19f0fe" } } $('.js-work-strip[data-work-id=79879159]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879159,"title":"Transverse Upper Gracilis Flap with Implant In Postmastectomy Breast Reconstruction: a Case Report","translated_title":"","metadata":{"publisher":"Wiley","grobid_abstract":"Autologous flaps can be used in combination with prosthesis in postmastectomy breast reconstruction. The deep inferior epigastric perforator (DIEP) flap is considered the preferred choice among autologous tissue transfer techniques. However, in patients with a peculiar figure (moderately large breasts and large thighs with flat stomach), who cannot use their abdominal tissue, the transverse upper gracilis (TUG) flap with implant is investigated as a further option for breast reconstruction. This report presents a patient who underwent the TUG flap plus implant reconstruction. A bilateral skin-sparing mastectomy was performed removing 340 g for each breast. The volume of the TUG flaps was 225 g (left) and 250 g (right). Preoperative volumes were restored by placing under the TUG muscle a round textured implant. No complications occurred during the postoperative period both in the recipient and donor site and the outcomes of the procedure were good. In cases where the use of the DIEP flap is not possible because of past laparotomies or inadequate abdominal volume, the TUG flap plus implant may be considered as a valid alternative.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Microsurgery","grobid_abstract_attachment_id":86445737},"translated_abstract":null,"internal_url":"https://www.academia.edu/79879159/Transverse_Upper_Gracilis_Flap_with_Implant_In_Postmastectomy_Breast_Reconstruction_a_Case_Report","translated_internal_url":"","created_at":"2022-05-25T02:30:41.179-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86445737,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445737/thumbnails/1.jpg","file_name":"micr.2216520220525-1-1sde0by.pdf","download_url":"https://www.academia.edu/attachments/86445737/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Transverse_Upper_Gracilis_Flap_with_Impl.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445737/micr.2216520220525-1-1sde0by-libre.pdf?1653471923=\u0026response-content-disposition=attachment%3B+filename%3DTransverse_Upper_Gracilis_Flap_with_Impl.pdf\u0026Expires=1732809418\u0026Signature=IU8HKyBBgdPy0jIQh5pkSi6DTBEQCkISSIWoh~jnAnkqBXcmKnWr-uCPPzlIkkb8Kj1NUWhx-8oBIbdRf-ns6UHCJEWiEFbRCYAENrnuPu9ZbBmd8G4cq7UNy77N1EGEoiTK8p5LPhWsqyxOeK8ehIBXc92~WVAfsj0jIFZDDkc2JC4B~A4VMyvk-N24UotQ8x1g9hHWkFmfBpBXA-DUIFS7jFxAjsJsAZs-F0DCQfYL6xMiZLLtUZDAiaF15Q-CoI3SEGFFs6dfktiXqkZS0rtxag2By8d8Fv0lJe87tAOJnIPjnwoESC0vvXz6D06jx3hxaysZPloZCWiAVyuTrw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Transverse_Upper_Gracilis_Flap_with_Implant_In_Postmastectomy_Breast_Reconstruction_a_Case_Report","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[{"id":86445737,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445737/thumbnails/1.jpg","file_name":"micr.2216520220525-1-1sde0by.pdf","download_url":"https://www.academia.edu/attachments/86445737/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Transverse_Upper_Gracilis_Flap_with_Impl.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445737/micr.2216520220525-1-1sde0by-libre.pdf?1653471923=\u0026response-content-disposition=attachment%3B+filename%3DTransverse_Upper_Gracilis_Flap_with_Impl.pdf\u0026Expires=1732809418\u0026Signature=IU8HKyBBgdPy0jIQh5pkSi6DTBEQCkISSIWoh~jnAnkqBXcmKnWr-uCPPzlIkkb8Kj1NUWhx-8oBIbdRf-ns6UHCJEWiEFbRCYAENrnuPu9ZbBmd8G4cq7UNy77N1EGEoiTK8p5LPhWsqyxOeK8ehIBXc92~WVAfsj0jIFZDDkc2JC4B~A4VMyvk-N24UotQ8x1g9hHWkFmfBpBXA-DUIFS7jFxAjsJsAZs-F0DCQfYL6xMiZLLtUZDAiaF15Q-CoI3SEGFFs6dfktiXqkZS0rtxag2By8d8Fv0lJe87tAOJnIPjnwoESC0vvXz6D06jx3hxaysZPloZCWiAVyuTrw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4228,"name":"Skeletal muscle biology","url":"https://www.academia.edu/Documents/in/Skeletal_muscle_biology"},{"id":10126,"name":"Microsurgery","url":"https://www.academia.edu/Documents/in/Microsurgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":231720,"name":"Mastectomy","url":"https://www.academia.edu/Documents/in/Mastectomy"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":1146774,"name":"Thigh","url":"https://www.academia.edu/Documents/in/Thigh"},{"id":3724721,"name":"Surgical Flaps","url":"https://www.academia.edu/Documents/in/Surgical_Flaps"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879158"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879158/Secondary_shaping_of_the_free_TRAM_an_inferior_pedicle_reduction_mammaplasty"><img alt="Research paper thumbnail of Secondary shaping of the free TRAM: an inferior pedicle reduction mammaplasty" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879158/Secondary_shaping_of_the_free_TRAM_an_inferior_pedicle_reduction_mammaplasty">Secondary shaping of the free TRAM: an inferior pedicle reduction mammaplasty</a></div><div class="wp-workCard_item"><span>Journal of Plastic, Reconstructive & Aesthetic Surgery</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Secondary shaping of the transverse rectus abdominis myocutaneous (TRAM) flap is a routine treatm...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Secondary shaping of the transverse rectus abdominis myocutaneous (TRAM) flap is a routine treatment, and includes liposuction, skin excision, inframammary fold replacement, dermal fat grafts or lipofilling. Major flap revision may include an augmentation procedure with implants or expanders. We present an inferior pedicle breast reduction in a woman who underwent breast reconstruction using a free TRAM flap. To our knowledge, there are no reports about reduction mammaplasty or mastopexy in Free TRAM flap breast reconstruction. Reduction mammaplasty should be regarded as a valuable option in free TRAM or deep inferior epigastric perforator secondary reshaping.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879158"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879158"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879158; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879158]").text(description); $(".js-view-count[data-work-id=79879158]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879158; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879158']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879158, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=79879158]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879158,"title":"Secondary shaping of the free TRAM: an inferior pedicle reduction mammaplasty","translated_title":"","metadata":{"abstract":"Secondary shaping of the transverse rectus abdominis myocutaneous (TRAM) flap is a routine treatment, and includes liposuction, skin excision, inframammary fold replacement, dermal fat grafts or lipofilling. Major flap revision may include an augmentation procedure with implants or expanders. We present an inferior pedicle breast reduction in a woman who underwent breast reconstruction using a free TRAM flap. To our knowledge, there are no reports about reduction mammaplasty or mastopexy in Free TRAM flap breast reconstruction. Reduction mammaplasty should be regarded as a valuable option in free TRAM or deep inferior epigastric perforator secondary reshaping.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Journal of Plastic, Reconstructive \u0026 Aesthetic Surgery"},"translated_abstract":"Secondary shaping of the transverse rectus abdominis myocutaneous (TRAM) flap is a routine treatment, and includes liposuction, skin excision, inframammary fold replacement, dermal fat grafts or lipofilling. Major flap revision may include an augmentation procedure with implants or expanders. We present an inferior pedicle breast reduction in a woman who underwent breast reconstruction using a free TRAM flap. To our knowledge, there are no reports about reduction mammaplasty or mastopexy in Free TRAM flap breast reconstruction. Reduction mammaplasty should be regarded as a valuable option in free TRAM or deep inferior epigastric perforator secondary reshaping.","internal_url":"https://www.academia.edu/79879158/Secondary_shaping_of_the_free_TRAM_an_inferior_pedicle_reduction_mammaplasty","translated_internal_url":"","created_at":"2022-05-25T02:30:41.014-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Secondary_shaping_of_the_free_TRAM_an_inferior_pedicle_reduction_mammaplasty","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":100533,"name":"Breast Reduction","url":"https://www.academia.edu/Documents/in/Breast_Reduction"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies"},{"id":231720,"name":"Mastectomy","url":"https://www.academia.edu/Documents/in/Mastectomy"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":2482067,"name":"Reoperation","url":"https://www.academia.edu/Documents/in/Reoperation"},{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms"},{"id":3724721,"name":"Surgical Flaps","url":"https://www.academia.edu/Documents/in/Surgical_Flaps"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879157"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879157/Is_mammary_reconstruction_with_the_anatomical_Becker_expander_a_simple_procedure_Complications_and_hidden_problems_leading_to_secondary_surgical_procedures_A_follow_up_study"><img alt="Research paper thumbnail of Is mammary reconstruction with the anatomical Becker expander a simple procedure? Complications and hidden problems leading to secondary surgical procedures: A follow-up study" class="work-thumbnail" src="https://attachments.academia-assets.com/86445741/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879157/Is_mammary_reconstruction_with_the_anatomical_Becker_expander_a_simple_procedure_Complications_and_hidden_problems_leading_to_secondary_surgical_procedures_A_follow_up_study">Is mammary reconstruction with the anatomical Becker expander a simple procedure? Complications and hidden problems leading to secondary surgical procedures: A follow-up study</a></div><div class="wp-workCard_item"><span>Journal of Plastic, Reconstructive & Aesthetic Surgery</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a599d0bd1062ee35bdb970a47a635439" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445741,"asset_id":79879157,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445741/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879157"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879157"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879157; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879157]").text(description); $(".js-view-count[data-work-id=79879157]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879157; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879157']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879157, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a599d0bd1062ee35bdb970a47a635439" } } $('.js-work-strip[data-work-id=79879157]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879157,"title":"Is mammary reconstruction with the anatomical Becker expander a simple procedure? Complications and hidden problems leading to secondary surgical procedures: A follow-up study","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Debate over the role of Becker expander implants (BEIs) in breast reconstruction is still ongoing. There are no clear indications for BEI use. The main indications for BEI use are one-stage breast reconstruction procedure and congenital breast deformities correction, due to the postoperative ability to vary BEI volume. Recent studies showed that BEIs were removed 5 years after mammary reconstruction in 68% of operated patients. This entails a further surgical procedure. BEIs should not, therefore, be regarded as one-stage prostheses. We performed a case-series study of breast reconstructions with anatomically shaped Becker-35盲 implants, in order to highlight complications and to flag unseen problems, which might entail a second surgical procedure. A total of 229 patients, reconstructed from 2005 to 2010, were enrolled in this study. Data relating to implant type, volume, mean operative time and complications were recorded. All the patients underwent the same surgical procedure. The minimum follow-up period was 18 months. During a 5-year follow-up, 99 patients required secondary surgery to correct their complications or sequelae; 46 of them underwent BEI removal within 2 years of implantation, 56 within 3 years, 65 within 4 years and 74 within 5 years. Our findings show that two different sorts of complications can arise with these devices, leading to premature implant removal, one common to any breast implant and one peculiar to BEIs. The Becker implant is a permanent expander. Surgeons must, therefore, be aware that, once positioned, the Becker expander cannot be adjusted at a later date, as in two-stage expander/prosthesis reconstructions for instance. Surgeons must have a clear understanding","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Journal of Plastic, Reconstructive \u0026 Aesthetic Surgery","grobid_abstract_attachment_id":86445741},"translated_abstract":null,"internal_url":"https://www.academia.edu/79879157/Is_mammary_reconstruction_with_the_anatomical_Becker_expander_a_simple_procedure_Complications_and_hidden_problems_leading_to_secondary_surgical_procedures_A_follow_up_study","translated_internal_url":"","created_at":"2022-05-25T02:30:40.864-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86445741,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445741/thumbnails/1.jpg","file_name":"j.bjps.2013.02.00420220525-1-m43ckz.pdf","download_url":"https://www.academia.edu/attachments/86445741/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Is_mammary_reconstruction_with_the_anato.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445741/j.bjps.2013.02.00420220525-1-m43ckz-libre.pdf?1653471925=\u0026response-content-disposition=attachment%3B+filename%3DIs_mammary_reconstruction_with_the_anato.pdf\u0026Expires=1732809418\u0026Signature=PDRS3h70itliNQzgAK7P7NwR5lKv6iAr~5kWJudVUIEFBpM082aLZXGZ1bTol-HYoIhONemInxcq1eN9b0LBGRMpw4jl6mxGqWuitD2QCN0oJ3NgHSn1K0sg3exjuo9VHhR57CH22n5Igb6HqKJlNpbgIcyWJ0wGTG6dBrAotSW0D14D~~2BiLDANZXCy4EoIjltRYwoukibx4ti5EAZ~APvhI63~HKf8JBS2qtN9IZpZNZaQMNlF7ixNu4VDzIltAqxoOMWDqbru88sSb38VeOYjxF1Bc6cuH66fOCj1nzeAkQ6UwFCJsVrPfGF1ZIEc10Fer~kKmSjOSNULkiGdg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Is_mammary_reconstruction_with_the_anatomical_Becker_expander_a_simple_procedure_Complications_and_hidden_problems_leading_to_secondary_surgical_procedures_A_follow_up_study","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[{"id":86445741,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86445741/thumbnails/1.jpg","file_name":"j.bjps.2013.02.00420220525-1-m43ckz.pdf","download_url":"https://www.academia.edu/attachments/86445741/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Is_mammary_reconstruction_with_the_anato.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86445741/j.bjps.2013.02.00420220525-1-m43ckz-libre.pdf?1653471925=\u0026response-content-disposition=attachment%3B+filename%3DIs_mammary_reconstruction_with_the_anato.pdf\u0026Expires=1732809418\u0026Signature=PDRS3h70itliNQzgAK7P7NwR5lKv6iAr~5kWJudVUIEFBpM082aLZXGZ1bTol-HYoIhONemInxcq1eN9b0LBGRMpw4jl6mxGqWuitD2QCN0oJ3NgHSn1K0sg3exjuo9VHhR57CH22n5Igb6HqKJlNpbgIcyWJ0wGTG6dBrAotSW0D14D~~2BiLDANZXCy4EoIjltRYwoukibx4ti5EAZ~APvhI63~HKf8JBS2qtN9IZpZNZaQMNlF7ixNu4VDzIltAqxoOMWDqbru88sSb38VeOYjxF1Bc6cuH66fOCj1nzeAkQ6UwFCJsVrPfGF1ZIEc10Fer~kKmSjOSNULkiGdg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":39516,"name":"Breast Implants","url":"https://www.academia.edu/Documents/in/Breast_Implants"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":715808,"name":"prosthesis Design","url":"https://www.academia.edu/Documents/in/prosthesis_Design"},{"id":2463621,"name":"Postoperative Complications","url":"https://www.academia.edu/Documents/in/Postoperative_Complications"},{"id":2482067,"name":"Reoperation","url":"https://www.academia.edu/Documents/in/Reoperation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879156"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879156/Toxic_epidermal_necrolysis_Lyells_disease_"><img alt="Research paper thumbnail of Toxic epidermal necrolysis (Lyell's disease)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879156/Toxic_epidermal_necrolysis_Lyells_disease_">Toxic epidermal necrolysis (Lyell's disease)</a></div><div class="wp-workCard_item"><span>Burns</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse drug react...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse drug reactions, characterized by a low incidence but high mortality, initially described as separate entities, but today considered variants of the same pathologic process and differing only for severity. The majority of cases appear to be related to idiosyncratic drug reactions. The drugs most commonly involved are: antibiotics such as sulfonamides, beta-lactam, tetracyclines and quinolones; anticonvulsants such as phenytoin, phenobarbital and carbamazapine; antiretroviral drugs; nonsteroidal anti-inflammatory drugs, allopurinol. There is common agreement to consider TEN as the manifestation of a disregulated immune reaction against epithelial cells. During the first stages of TEN, apoptosis mediates keratinocyte death and the pivotal role of Fas-FasL pathway activation during TEN is undoubted. T cell cytotoxicity, demonstrated during TEN, has been shown to be mediated by the perforin-granzyme pathway. It seems, also, clear that a peculiar cytokine pattern plays an important role in TEN pathogenesis. The cutaneous findings result in an acute macular erythematous rash with bullae. These lesions rapidly exhibit Nikolsky&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s sign and a separation of large sheets of epidermis from the dermis and a subsequent localised shedding develops rapidly, which can become very extensive. When feasible, admission in burn or intensive care unit, positioning the patients in air-fluidised beds, is universally considered crucial in TEN treatment. The prompt withdrawal of the suspected drug, fluid and electrolyte replacement and topical wound care are the first line of therapy. The use of corticosteroids has been abandoned and the role of immunosuppressants, despite some success, is not well defined and is not considered as a standard. A trial comparing thalidomide versus placebo in TEN patients was suspended because mortality rate increased in the treated group. Infliximab, a chimeric monoclonal antibody to TNF-alpha, has been administered to a patient, in single infusion, with a favourable outcome. Plasmapheresis is reported to lead to some success in TEN treatment, with improvement of clinical conditions and high percentage of survival. Different authors reported good results in terms of decreasing mortality and morbidity or improving clinical conditions of the use of human intravenous immunoglobulins (IVIGs). Regardless, the true utility of this treatment remains controversial. In 2005, the authors (ML and RC), dealing with a number of severe TEN cases, proposed a new protocol based on the combination of these last two techniques reporting their preliminary results in the treatment of severe TEN patients.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879156"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879156"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879156; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879156]").text(description); $(".js-view-count[data-work-id=79879156]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879156; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879156']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879156, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=79879156]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879156,"title":"Toxic epidermal necrolysis (Lyell's disease)","translated_title":"","metadata":{"abstract":"Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse drug reactions, characterized by a low incidence but high mortality, initially described as separate entities, but today considered variants of the same pathologic process and differing only for severity. The majority of cases appear to be related to idiosyncratic drug reactions. The drugs most commonly involved are: antibiotics such as sulfonamides, beta-lactam, tetracyclines and quinolones; anticonvulsants such as phenytoin, phenobarbital and carbamazapine; antiretroviral drugs; nonsteroidal anti-inflammatory drugs, allopurinol. There is common agreement to consider TEN as the manifestation of a disregulated immune reaction against epithelial cells. During the first stages of TEN, apoptosis mediates keratinocyte death and the pivotal role of Fas-FasL pathway activation during TEN is undoubted. T cell cytotoxicity, demonstrated during TEN, has been shown to be mediated by the perforin-granzyme pathway. It seems, also, clear that a peculiar cytokine pattern plays an important role in TEN pathogenesis. The cutaneous findings result in an acute macular erythematous rash with bullae. These lesions rapidly exhibit Nikolsky\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s sign and a separation of large sheets of epidermis from the dermis and a subsequent localised shedding develops rapidly, which can become very extensive. When feasible, admission in burn or intensive care unit, positioning the patients in air-fluidised beds, is universally considered crucial in TEN treatment. The prompt withdrawal of the suspected drug, fluid and electrolyte replacement and topical wound care are the first line of therapy. The use of corticosteroids has been abandoned and the role of immunosuppressants, despite some success, is not well defined and is not considered as a standard. A trial comparing thalidomide versus placebo in TEN patients was suspended because mortality rate increased in the treated group. Infliximab, a chimeric monoclonal antibody to TNF-alpha, has been administered to a patient, in single infusion, with a favourable outcome. Plasmapheresis is reported to lead to some success in TEN treatment, with improvement of clinical conditions and high percentage of survival. Different authors reported good results in terms of decreasing mortality and morbidity or improving clinical conditions of the use of human intravenous immunoglobulins (IVIGs). Regardless, the true utility of this treatment remains controversial. In 2005, the authors (ML and RC), dealing with a number of severe TEN cases, proposed a new protocol based on the combination of these last two techniques reporting their preliminary results in the treatment of severe TEN patients.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Burns"},"translated_abstract":"Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse drug reactions, characterized by a low incidence but high mortality, initially described as separate entities, but today considered variants of the same pathologic process and differing only for severity. The majority of cases appear to be related to idiosyncratic drug reactions. The drugs most commonly involved are: antibiotics such as sulfonamides, beta-lactam, tetracyclines and quinolones; anticonvulsants such as phenytoin, phenobarbital and carbamazapine; antiretroviral drugs; nonsteroidal anti-inflammatory drugs, allopurinol. There is common agreement to consider TEN as the manifestation of a disregulated immune reaction against epithelial cells. During the first stages of TEN, apoptosis mediates keratinocyte death and the pivotal role of Fas-FasL pathway activation during TEN is undoubted. T cell cytotoxicity, demonstrated during TEN, has been shown to be mediated by the perforin-granzyme pathway. It seems, also, clear that a peculiar cytokine pattern plays an important role in TEN pathogenesis. The cutaneous findings result in an acute macular erythematous rash with bullae. These lesions rapidly exhibit Nikolsky\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s sign and a separation of large sheets of epidermis from the dermis and a subsequent localised shedding develops rapidly, which can become very extensive. When feasible, admission in burn or intensive care unit, positioning the patients in air-fluidised beds, is universally considered crucial in TEN treatment. The prompt withdrawal of the suspected drug, fluid and electrolyte replacement and topical wound care are the first line of therapy. The use of corticosteroids has been abandoned and the role of immunosuppressants, despite some success, is not well defined and is not considered as a standard. A trial comparing thalidomide versus placebo in TEN patients was suspended because mortality rate increased in the treated group. Infliximab, a chimeric monoclonal antibody to TNF-alpha, has been administered to a patient, in single infusion, with a favourable outcome. Plasmapheresis is reported to lead to some success in TEN treatment, with improvement of clinical conditions and high percentage of survival. Different authors reported good results in terms of decreasing mortality and morbidity or improving clinical conditions of the use of human intravenous immunoglobulins (IVIGs). Regardless, the true utility of this treatment remains controversial. In 2005, the authors (ML and RC), dealing with a number of severe TEN cases, proposed a new protocol based on the combination of these last two techniques reporting their preliminary results in the treatment of severe TEN patients.","internal_url":"https://www.academia.edu/79879156/Toxic_epidermal_necrolysis_Lyells_disease_","translated_internal_url":"","created_at":"2022-05-25T02:30:40.701-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Toxic_epidermal_necrolysis_Lyells_disease_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":162553,"name":"Skin","url":"https://www.academia.edu/Documents/in/Skin"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":263029,"name":"Intensive Care Unit","url":"https://www.academia.edu/Documents/in/Intensive_Care_Unit"},{"id":284338,"name":"Stevens Johnson Syndrome","url":"https://www.academia.edu/Documents/in/Stevens_Johnson_Syndrome"},{"id":295466,"name":"Plasmapheresis","url":"https://www.academia.edu/Documents/in/Plasmapheresis"},{"id":367190,"name":"Burns","url":"https://www.academia.edu/Documents/in/Burns"},{"id":441679,"name":"Adverse Drug Reaction","url":"https://www.academia.edu/Documents/in/Adverse_Drug_Reaction"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":1177144,"name":"Epithelial Cell Biology","url":"https://www.academia.edu/Documents/in/Epithelial_Cell_Biology"},{"id":1436363,"name":"Toxic Epidermal Necrolysis","url":"https://www.academia.edu/Documents/in/Toxic_Epidermal_Necrolysis"},{"id":1489223,"name":"Intravenous Immunoglobulin","url":"https://www.academia.edu/Documents/in/Intravenous_Immunoglobulin"},{"id":1680434,"name":"Mortality rate","url":"https://www.academia.edu/Documents/in/Mortality_rate"},{"id":2562571,"name":"Immunosuppressive Agents","url":"https://www.academia.edu/Documents/in/Immunosuppressive_Agents"},{"id":3785460,"name":"Nonsteroidal Anti-inflammatory Drug","url":"https://www.academia.edu/Documents/in/Nonsteroidal_Anti_inflammatory_Drug"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79879155"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79879155/Ultrastructural_Anatomy_of_Contracted_Capsules_Around_Textured_Implants_in_Augmented_Breasts"><img alt="Research paper thumbnail of Ultrastructural Anatomy of Contracted Capsules Around Textured Implants in Augmented Breasts" class="work-thumbnail" src="https://attachments.academia-assets.com/86445781/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79879155/Ultrastructural_Anatomy_of_Contracted_Capsules_Around_Textured_Implants_in_Augmented_Breasts">Ultrastructural Anatomy of Contracted Capsules Around Textured Implants in Augmented Breasts</a></div><div class="wp-workCard_item"><span>Annals of Plastic Surgery</span><span>, 2001</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="29c18cb0572c9c54d7fa585e35ed5c38" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445781,"asset_id":79879155,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445781/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79879155"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79879155"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79879155; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79879155]").text(description); $(".js-view-count[data-work-id=79879155]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79879155; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79879155']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79879155, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "29c18cb0572c9c54d7fa585e35ed5c38" } } $('.js-work-strip[data-work-id=79879155]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79879155,"title":"Ultrastructural Anatomy of Contracted Capsules Around Textured Implants in Augmented Breasts","translated_title":"","metadata":{"publisher":"Ovid Technologies (Wolters Kluwer Health)","grobid_abstract":"The development of a capsule around an implant is part of the physiological response to a foreign body. Capsular contracture is the most specific and frustrating complication of augmentation mammaplasty, and a lot of studies have been devoted to it. The aim of the current study is to examine the fine architecture of the contracted capsule around textured implants in humans. Eight capsules from augmented and contracted breasts with gel-filled, textured-surface silicone implants were studied after standard preparation for light and scanning electron microscopy, and after partial digestion in sodium hydroxide. Two capsules from contracted breasts around smooth implants and two noncontracted capsules around textured implants were prepared and studied in the same fashion as controls. A multilayer structure of the contracted capsule was seen, and the architecture of the various layers is described. The inner surface presents irregular craterlike depressions. The arrangement of collagen fibers varies in capsule layers. The effect of a textured-surface implant on the mechanism of capsule contraction based on the observed capsular architecture is that only part of the capsule is effective mechanically in producing a contracting force. 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In the literature, this tumor has sometimes been described in proximity of breast implants (60 implant-related ALCL reported). In 2010, a patient who had undergone a right mastectomy and tissue expander/implant reconstruction for a ''ductal'' carcinoma 10 years before was referred to our unit for evaluation. On examination, an enlarged reconstructed right breast was found. The reconstructed breast did not show tenderness or signs of infection, ulceration, or breakdown. Mammograms and ultrasound scan did not suggest the presence of recurrent cancer, infection, deflation of the implant, or severe capsule contracture. The patient underwent mammary implant replacement. About 3 weeks after surgery, the patient came back to our unit for a new mild enlargement of the operated breast and the implant was removed. Three months later, the patient returned with a skin lesion in the right parasternal region. A radical excisional biopsy was performed under local anesthesia and the diagnosis of ALK-1-negative ALCL was finally made. The clinical and histological diagnosis of this disease is difficult","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Aesthetic Plastic 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permanence in breast reconstruction with Becker implant</a></div><div class="wp-workCard_item"><span>Journal of Plastic, Reconstructive & Aesthetic Surgery</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ea3249d11dec8c363179b392380fe791" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86445664,"asset_id":79878979,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86445664/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79878979"><a 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href="https://www.academia.edu/73940909/CT_3D_reconstruction_of_the_arterial_network_of_anatomic_specimens_development_of_a_new_contrast_medium"><img alt="Research paper thumbnail of CT 3D reconstruction of the arterial network of anatomic specimens: development of a new contrast medium" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/73940909/CT_3D_reconstruction_of_the_arterial_network_of_anatomic_specimens_development_of_a_new_contrast_medium">CT 3D reconstruction of the arterial network of anatomic specimens: development of a new contrast medium</a></div><div class="wp-workCard_item"><span>Italian Journal of Anatomy and Embryology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: The development of autologous tissue transfer techniques in plastic surgery has enc...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: The development of autologous tissue transfer techniques in plastic surgery has encouraged the research into cutaneous vascularization. This has resulted in the revival of interest in ancient techniques and in the development of new and more effective techniques. Riolano was the first to carry out studies of vascular injection [1]. Various substances have been used to fill blood vessels to facilitate dissection. The discovery of X rays revolutionized the field of vascular anatomy [2]. Barium sulfate was soon replaced by lead oxide as the standard contrast agent for injection studies. However, the toxicity of lead oxide limits the application of these techniques and exposes the operator to risks and raises the issue of its disposal. [3]. Two-dimensional contrast radiography has been the standard for investigating the vascular anatomy of surgical flaps. Today, new imaging techniques are available. Static CT angiography enables to evaluate vascular anatomy in 3D and high detail. The aim of this study is to propose a new contrast formula to visualize the vessels in TC 3D studies [4]. Materials and methods: A new contrast agent for CT injection studies has been developed. First the substance must be evaluated with standard radiography to confirm the X-ray blocking properties. Then, various anatomical, human and animal, specimens have been injected, and subjected to CT scan. The data have been processed with Osirix software for 3D reconstruction. Results: the radiopacity was confirmed. CT scan 3D reconstruction showed a good level of detail. Conclusion: our new formula appears to be effective. The radiopacity of the medium can be adapted to tissue characteristics. Our formula allows an easier dissection and a detailed reconstruction of the vessels. Moreover the final polymer is non-toxic.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73940909"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73940909"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73940909; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73940909]").text(description); $(".js-view-count[data-work-id=73940909]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73940909; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73940909']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73940909, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73940909]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73940909,"title":"CT 3D reconstruction of the arterial network of anatomic specimens: development of a new contrast medium","translated_title":"","metadata":{"abstract":"Introduction: The development of autologous tissue transfer techniques in plastic surgery has encouraged the research into cutaneous vascularization. This has resulted in the revival of interest in ancient techniques and in the development of new and more effective techniques. Riolano was the first to carry out studies of vascular injection [1]. Various substances have been used to fill blood vessels to facilitate dissection. The discovery of X rays revolutionized the field of vascular anatomy [2]. Barium sulfate was soon replaced by lead oxide as the standard contrast agent for injection studies. However, the toxicity of lead oxide limits the application of these techniques and exposes the operator to risks and raises the issue of its disposal. [3]. Two-dimensional contrast radiography has been the standard for investigating the vascular anatomy of surgical flaps. Today, new imaging techniques are available. Static CT angiography enables to evaluate vascular anatomy in 3D and high detail. The aim of this study is to propose a new contrast formula to visualize the vessels in TC 3D studies [4]. Materials and methods: A new contrast agent for CT injection studies has been developed. First the substance must be evaluated with standard radiography to confirm the X-ray blocking properties. Then, various anatomical, human and animal, specimens have been injected, and subjected to CT scan. The data have been processed with Osirix software for 3D reconstruction. Results: the radiopacity was confirmed. CT scan 3D reconstruction showed a good level of detail. Conclusion: our new formula appears to be effective. The radiopacity of the medium can be adapted to tissue characteristics. Our formula allows an easier dissection and a detailed reconstruction of the vessels. 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Two-dimensional contrast radiography has been the standard for investigating the vascular anatomy of surgical flaps. Today, new imaging techniques are available. Static CT angiography enables to evaluate vascular anatomy in 3D and high detail. The aim of this study is to propose a new contrast formula to visualize the vessels in TC 3D studies [4]. Materials and methods: A new contrast agent for CT injection studies has been developed. First the substance must be evaluated with standard radiography to confirm the X-ray blocking properties. Then, various anatomical, human and animal, specimens have been injected, and subjected to CT scan. The data have been processed with Osirix software for 3D reconstruction. Results: the radiopacity was confirmed. CT scan 3D reconstruction showed a good level of detail. Conclusion: our new formula appears to be effective. The radiopacity of the medium can be adapted to tissue characteristics. Our formula allows an easier dissection and a detailed reconstruction of the vessels. Moreover the final polymer is non-toxic.","internal_url":"https://www.academia.edu/73940909/CT_3D_reconstruction_of_the_arterial_network_of_anatomic_specimens_development_of_a_new_contrast_medium","translated_internal_url":"","created_at":"2022-03-17T04:19:34.311-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"CT_3D_reconstruction_of_the_arterial_network_of_anatomic_specimens_development_of_a_new_contrast_medium","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":171327,"name":"3-D Reconstruction","url":"https://www.academia.edu/Documents/in/3-D_Reconstruction"}],"urls":[{"id":18574558,"url":"http://www.fupress.net/index.php/ijae/article/download/11859/11271"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="67225795"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/67225795/I_carcinomi_in_situ_della_mammella_inquadramento_clinico_ed_attualit%C3%A0_terapeutiche_Commentary"><img alt="Research paper thumbnail of I carcinomi in situ della mammella : inquadramento clinico ed attualit脿 terapeutiche. Commentary" class="work-thumbnail" src="https://attachments.academia-assets.com/78122098/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/67225795/I_carcinomi_in_situ_della_mammella_inquadramento_clinico_ed_attualit%C3%A0_terapeutiche_Commentary">I carcinomi in situ della mammella : inquadramento clinico ed attualit脿 terapeutiche. Commentary</a></div><div class="wp-workCard_item"><span>Annali Italiani Di Chirurgia</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c19b013cd42c09a78c0f4eb6c37fd516" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":78122098,"asset_id":67225795,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/78122098/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="67225795"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="67225795"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 67225795; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=67225795]").text(description); $(".js-view-count[data-work-id=67225795]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 67225795; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='67225795']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 67225795, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c19b013cd42c09a78c0f4eb6c37fd516" } } $('.js-work-strip[data-work-id=67225795]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":67225795,"title":"I carcinomi in situ della mammella : inquadramento clinico ed attualit脿 terapeutiche. Commentary","translated_title":"","metadata":{"grobid_abstract":"In situ carcinomas of the breast: Clinic features and therapeutic strategies INTRODUCTION: Lobular and ductal carcinomas in situ of the breast (LCIS and DCIS) origin from the ductal-lobular unit of mammary gland, but they are characterized for different morphologic patterns and evolution. In 1980 they represent 1.4% of diagnosis in breast biopsy, less of 5% of carcinomas of the breast. Actually in 7.5% of breast biopsy an in situ carcinoma is recognized (approximating 40% of breast cancers). Our purpose is to evaluate the different available strategies in the clinic management of DCIS and LCIS and, in case of surgical treatment, which reconstructive approach obtains satisfactory breast conformation. MATERIALS AND METHODS: The study enclose 125 patients: 40 of them presented LCIS (32%) and 85 DCIS (68%). In 40 patients (32%) underposed to mastectomy was performed a reconstruction in cooperation with aesthetic surgeons. 35 of 40 women with LCIS are included in a follow-up programme, 5 of them had a bilateral mastectomy and reconstruction. RESULTS: No recurrences were observed in patients affected by LCIS. Six patients underposed to wide excision for DCIS developed local recurrence, treated by mastectomy. No recurrences were observed in patients treated initially with mastectomy. Some complications correlated to reconstruction were detected. CONCLUSIONS: One of most controversial sights in breast pathology is the understanding of biological meaning of CLIS: in facts CDIS can be considered a pre-invasive cancer, CLIS is reasonably considerable only a risk indicator for developing breast cancer but it isn't a pre-neoplastic lesion. Very important is the reconstruction of the breast to improve the quality life of patients.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Annali Italiani Di Chirurgia","grobid_abstract_attachment_id":78122098},"translated_abstract":null,"internal_url":"https://www.academia.edu/67225795/I_carcinomi_in_situ_della_mammella_inquadramento_clinico_ed_attualit%C3%A0_terapeutiche_Commentary","translated_internal_url":"","created_at":"2022-01-05T06:04:35.005-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":78122098,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/78122098/thumbnails/1.jpg","file_name":"003-012-min.pdf","download_url":"https://www.academia.edu/attachments/78122098/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"I_carcinomi_in_situ_della_mammella_inqua.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/78122098/003-012-min-libre.pdf?1641392155=\u0026response-content-disposition=attachment%3B+filename%3DI_carcinomi_in_situ_della_mammella_inqua.pdf\u0026Expires=1732809419\u0026Signature=LRPlbn1qSllXbACrSubKXzTRNZJFjN4paKY9jzeG8nAdXNtv1IGDniL-aY~B3fqOPe2wxmClDz1f91CuZSrdZaalgOXE2BbYgl9trw9~oh81WVP1AoDnSD6OKLjXUlQsm5JeTGpXHtkqCrnh~N6Bx9CFcOEVrvHZ5-PwS9JXybHca9YM6y3ZX~WIuDPOq8NlWBE-4HXUxhtDlozbItKB4B9ityy6zsueI9UTBoHuE5~nF9-Ak5LxPO1odn3ItivhrEkHSPYICkY65cMayUg65Oe6nuv5ruZwU~9E65eqKkrr1LPgx8e~nB-Grv0yoTzdNJOAIxBQfytUvQXyzuL3kQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"I_carcinomi_in_situ_della_mammella_inquadramento_clinico_ed_attualit脿_terapeutiche_Commentary","translated_slug":"","page_count":10,"language":"it","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[{"id":78122098,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/78122098/thumbnails/1.jpg","file_name":"003-012-min.pdf","download_url":"https://www.academia.edu/attachments/78122098/download_file?st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNTgxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"I_carcinomi_in_situ_della_mammella_inqua.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/78122098/003-012-min-libre.pdf?1641392155=\u0026response-content-disposition=attachment%3B+filename%3DI_carcinomi_in_situ_della_mammella_inqua.pdf\u0026Expires=1732809419\u0026Signature=LRPlbn1qSllXbACrSubKXzTRNZJFjN4paKY9jzeG8nAdXNtv1IGDniL-aY~B3fqOPe2wxmClDz1f91CuZSrdZaalgOXE2BbYgl9trw9~oh81WVP1AoDnSD6OKLjXUlQsm5JeTGpXHtkqCrnh~N6Bx9CFcOEVrvHZ5-PwS9JXybHca9YM6y3ZX~WIuDPOq8NlWBE-4HXUxhtDlozbItKB4B9ityy6zsueI9UTBoHuE5~nF9-Ak5LxPO1odn3ItivhrEkHSPYICkY65cMayUg65Oe6nuv5ruZwU~9E65eqKkrr1LPgx8e~nB-Grv0yoTzdNJOAIxBQfytUvQXyzuL3kQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[{"id":16108944,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=17964435"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="67225794"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/67225794/A_theoretical_model_describing_arterial_flow_in_the_DIEP_flap_related_to_number_and_size_of_perforator_vessels"><img alt="Research paper thumbnail of A theoretical model describing arterial flow in the DIEP flap related to number and size of perforator vessels" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/67225794/A_theoretical_model_describing_arterial_flow_in_the_DIEP_flap_related_to_number_and_size_of_perforator_vessels">A theoretical model describing arterial flow in the DIEP flap related to number and size of perforator vessels</a></div><div class="wp-workCard_item"><span>Journal of Plastic, Reconstructive & Aesthetic Surgery</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The deep inferior epigastric perforator flap is rapidly becoming a more widely employed method of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The deep inferior epigastric perforator flap is rapidly becoming a more widely employed method of autologous breast reconstruction. The technical considerations involved in the execution of the flap are many and include the selection of perforators to be incorporated in the flap. We attempt to give a mathematical explanation, based on the physics of flow through vessels and the properties of circuits with multiple resistances in parallel, for the clinical observations which have been arrived at through clinical experience. We compare the system of perforators to a circuit with multiple resistances in parallel. Each of these resistances represents a perforator vessel. In the event that there is only one perforator vessel, this simplifies to a single resistance in series with the capillary bed perfusing the flap. The flow through the flap is optimized by incorporation of the largest diameter perforator. Inclusion of other smaller perforators in addition to the largest diameter perforator will reduce the overall resistance, but this reduction in resistance is dependent on the diameter of the additional perforator and may not be worth the additional trauma of dissection and increased operative time. Incorporating several smaller perforators at the expense of excluding the largest diameter perforator appears to increase the overall resistance, unless the smaller perforators are only slightly smaller. We conclude that the best perfused flap involves use of the largest diameter vessel, that although adding additional perforators will decrease the resistance and increase flow, the magnitude of the benefit depends largely on the calibre of the additional perforator, and that this benefit needs to be weighed against the downside of increased muscle and facial trauma.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="67225794"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="67225794"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 67225794; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=67225794]").text(description); $(".js-view-count[data-work-id=67225794]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 67225794; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='67225794']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 67225794, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=67225794]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":67225794,"title":"A theoretical model describing arterial flow in the DIEP flap related to number and size of perforator vessels","translated_title":"","metadata":{"abstract":"The deep inferior epigastric perforator flap is rapidly becoming a more widely employed method of autologous breast reconstruction. The technical considerations involved in the execution of the flap are many and include the selection of perforators to be incorporated in the flap. We attempt to give a mathematical explanation, based on the physics of flow through vessels and the properties of circuits with multiple resistances in parallel, for the clinical observations which have been arrived at through clinical experience. We compare the system of perforators to a circuit with multiple resistances in parallel. Each of these resistances represents a perforator vessel. In the event that there is only one perforator vessel, this simplifies to a single resistance in series with the capillary bed perfusing the flap. The flow through the flap is optimized by incorporation of the largest diameter perforator. Inclusion of other smaller perforators in addition to the largest diameter perforator will reduce the overall resistance, but this reduction in resistance is dependent on the diameter of the additional perforator and may not be worth the additional trauma of dissection and increased operative time. Incorporating several smaller perforators at the expense of excluding the largest diameter perforator appears to increase the overall resistance, unless the smaller perforators are only slightly smaller. We conclude that the best perfused flap involves use of the largest diameter vessel, that although adding additional perforators will decrease the resistance and increase flow, the magnitude of the benefit depends largely on the calibre of the additional perforator, and that this benefit needs to be weighed against the downside of increased muscle and facial trauma.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Journal of Plastic, Reconstructive \u0026 Aesthetic Surgery"},"translated_abstract":"The deep inferior epigastric perforator flap is rapidly becoming a more widely employed method of autologous breast reconstruction. The technical considerations involved in the execution of the flap are many and include the selection of perforators to be incorporated in the flap. We attempt to give a mathematical explanation, based on the physics of flow through vessels and the properties of circuits with multiple resistances in parallel, for the clinical observations which have been arrived at through clinical experience. We compare the system of perforators to a circuit with multiple resistances in parallel. Each of these resistances represents a perforator vessel. In the event that there is only one perforator vessel, this simplifies to a single resistance in series with the capillary bed perfusing the flap. The flow through the flap is optimized by incorporation of the largest diameter perforator. Inclusion of other smaller perforators in addition to the largest diameter perforator will reduce the overall resistance, but this reduction in resistance is dependent on the diameter of the additional perforator and may not be worth the additional trauma of dissection and increased operative time. Incorporating several smaller perforators at the expense of excluding the largest diameter perforator appears to increase the overall resistance, unless the smaller perforators are only slightly smaller. We conclude that the best perfused flap involves use of the largest diameter vessel, that although adding additional perforators will decrease the resistance and increase flow, the magnitude of the benefit depends largely on the calibre of the additional perforator, and that this benefit needs to be weighed against the downside of increased muscle and facial trauma.","internal_url":"https://www.academia.edu/67225794/A_theoretical_model_describing_arterial_flow_in_the_DIEP_flap_related_to_number_and_size_of_perforator_vessels","translated_internal_url":"","created_at":"2022-01-05T06:04:34.800-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51298174,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"A_theoretical_model_describing_arterial_flow_in_the_DIEP_flap_related_to_number_and_size_of_perforator_vessels","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51298174,"first_name":"Corrado","middle_initials":null,"last_name":"Rubino","page_name":"RubinoCorrado","domain_name":"independent","created_at":"2016-07-24T03:28:42.052-07:00","display_name":"Corrado Rubino","url":"https://independent.academia.edu/RubinoCorrado"},"attachments":[],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":8017,"name":"Microcirculation","url":"https://www.academia.edu/Documents/in/Microcirculation"},{"id":8942,"name":"Treatment","url":"https://www.academia.edu/Documents/in/Treatment"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":413301,"name":"Perforation","url":"https://www.academia.edu/Documents/in/Perforation"},{"id":426588,"name":"Blood Flow","url":"https://www.academia.edu/Documents/in/Blood_Flow"},{"id":492043,"name":"Size","url":"https://www.academia.edu/Documents/in/Size"},{"id":1154248,"name":"Theoretical Model","url":"https://www.academia.edu/Documents/in/Theoretical_Model"},{"id":1969879,"name":"Vascular Resistance","url":"https://www.academia.edu/Documents/in/Vascular_Resistance"},{"id":3724721,"name":"Surgical Flaps","url":"https://www.academia.edu/Documents/in/Surgical_Flaps"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="67225793"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/67225793/A_Theoretical_Model_Describing_Arterial_Flow_In_the_DIEP_Flap_Related_to_Number_and_Size_of_Perforator_Vessels"><img alt="Research paper thumbnail of A Theoretical Model Describing Arterial Flow In the DIEP Flap Related to Number and Size of Perforator Vessels" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/67225793/A_Theoretical_Model_Describing_Arterial_Flow_In_the_DIEP_Flap_Related_to_Number_and_Size_of_Perforator_Vessels">A Theoretical Model Describing Arterial Flow In the DIEP Flap Related to Number and Size of Perforator Vessels</a></div><div class="wp-workCard_item"><span>J Plast Reconstr Aesthet Surg</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The deep inferior epigastric perforator flap is rapidly becoming a more widely employed method of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The deep inferior epigastric perforator flap is rapidly becoming a more widely employed method of autologous breast reconstruction. The technical considerations involved in the execution of the flap are many and include the selection of perforators to be incorporated in the flap. We attempt to give a mathematical explanation, based on the physics of flow through vessels and the properties of circuits with multiple resistances in parallel, for the clinical observations which have been arrived at through clinical experience. We compare the system of perforators to a circuit with multiple resistances in parallel. Each of these resistances represents a perforator vessel. In the event that there is only one perforator vessel, this simplifies to a single resistance in series with the capillary bed perfusing the flap. The flow through the flap is optimized by incorporation of the largest diameter perforator. Inclusion of other smaller perforators in addition to the largest diameter perforator will reduce the overall resistance, but this reduction in resistance is dependent on the diameter of the additional perforator and may not be worth the additional trauma of dissection and increased operative time. Incorporating several smaller perforators at the expense of excluding the largest diameter perforator appears to increase the overall resistance, unless the smaller perforators are only slightly smaller. 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