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By Title</option><option value="a-author">A-Z By Author</option><option value="z-author">Z-A By Author</option><option value="asc">Date Ascending</option><option value="desc">Date Descending</option></select></div></div><input type="hidden" name="start" form="facetForm" value="0"/></div><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/82v3r3f6"><div class="c-clientmarkup">2019 AIAA Design/Build/Fly</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AYeung%2C%20Nathan">Yeung, Nathan</a>; </li><li><a href="/search/?q=author%3ASevilla%2C%20Marlon">Sevilla, Marlon</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Brian">Chen, Brian</a>; </li><li><a href="/search/?q=author%3ADao%2C%20Adrienne">Dao, Adrienne</a>; </li><li><a href="/search/?q=author%3AHernandez%2C%20Erick">Hernandez, Erick</a>; </li><li><a href="/search/?q=author%3AReuter%2C%20Andrew">Reuter, Andrew</a>; </li><li><a href="/search/?q=author%3ABechler%2C%20James">Bechler, James</a>; </li><li><a href="/search/?q=author%3AHince%2C%20Sam">Hince, Sam</a>; </li><li><a href="/search/?q=author%3APatel%2C%20Aakash">Patel, Aakash</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ANguyen%2C%20Tina">Nguyen, Tina</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/uci_eng_rsda">SSOE Research Symposium Dean's Awards</a> (2019)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><p>Design / Build / Fly (DBF) is an annual and international remote controlled aircraft design competition that provides engineering students an opportunity to develop an aircraft that meets the competition requirements set by AIAA. This year’s competition requires teams to develop a short takeoff, carrier based aircraft with remotely folding wings and capable of carrying and releasing cargo. After analyzing the score analysis, our team determined that the highest scoring potential is to maximize the amount of stores carried while completing an equal number of laps within a 10 minute window. The team explored a wide range of options and finalized on an aircraft design that meets the given constraints while also excelling in mission performance. Our aircraft consists of a 75 in wingspan, an aspect ratio of 6.25, a maximum takeoff weight of 16 lbs, and a cargo capacity of 12 stores. Faculty Advisors: Professor Robert H. Liebeck; Advisors: Colin Sledge, Joseph Hsieh, Paul ParcelContact DBF Team • Nathan Yeung nhyeung@uci.edu • Marlon Sevilla marlonps@uci.edu • Brian Chen brianlc1@uci.eduEmail: dbf.uci.sdp@gmail.com Facebook: <a href="https://www.facebook.com/dbfuci/">https://www.facebook.com/dbfuci/</a> </p><p>For more information, visit: http://<a href="http://www.aiaadbf.org/">www.aiaadbf.org/</a> </p></div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/82v3r3f6"><img src="/cms-assets/d06f8eac640304ec53ea81db87ec4065bdb47fb61366a566c4cf270916112e65" alt="Cover page: 2019 AIAA Design/Build/Fly"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/5dp6j10g"><div class="c-clientmarkup">Vitamin B12 status and hyperhomocysteinemia in patients with Rheumatoid arthritis treated with methotrexate and folic acid</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3APatel%2C%20Aakash%20V">Patel, Aakash V</a>; </li><li><a href="/search/?q=author%3AMorgan%2C%20Sarah%20L">Morgan, Sarah L</a>; </li><li><a href="/search/?q=author%3AGreen%2C%20Ralph">Green, Ralph</a>; </li><li><a href="/search/?q=author%3ADanila%2C%20Maria%20I">Danila, Maria I</a>; </li><li><a href="/search/?q=author%3AMerriman%2C%20Tony%20R">Merriman, Tony R</a>; </li><li><a href="/search/?q=author%3AWanzeck%2C%20Keith">Wanzeck, Keith</a>; </li><li><a href="/search/?q=author%3AAhmed%2C%20Hamdy">Ahmed, Hamdy</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AGaffo%2C%20Angelo%20L">Gaffo, Angelo L</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucd_postprints">UC Davis Previously Published Works</a> (2024)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Background</h3>Rheumatoid arthritis (RA) is an inflammatory arthritis in which the immune system targets synovial joints. Methotrexate serves as the mainstay of treatment for RA due to its efficacy. However, patients treated with methotrexate are uniquely at risk for vitamin B12 deficiency and hyperhomocysteinemia due to coincident disease risk factors and the fact that methotrexate use is associated with malabsorption. The objective of this study was to assess for vitamin B12 deficiency among patients with RA treated with methotrexate and folic acid.<h3>Methods</h3>This cross-sectional study included 50 patients with RA treated with methotrexate and folic acid and 49 patients with RA treated with other therapies. Patients were matched by age, sex, race, renal function, and disease activity. We compared plasma vitamin B12, methylmalonic acid, and homocysteine levels between these two groups utilizing quantitative and categorical analyses.<h3>Results</h3>Thirty-seven (74%) RA patients on methotrexate and folic acid had elevated plasma homocysteine levels compared with only 27 (55%) RA patients receiving other therapies (P < 0.05). The proportion of patients with low vitamin B12 and high methylmalonic acid levels did not differ between the two groups.<h3>Conclusions</h3>Our data show high plasma homocysteine levels among RA patients treated with methotrexate and folic acid. While plasma vitamin B12 levels were similar between the two groups, high plasma homocysteine is also a sensitive marker of vitamin B12 deficiency. Additional studies should evaluate for the presence of clinical features of vitamin B12 deficiency and hyperhomocysteinemia among RA patients treated with methotrexate and folic acid.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/5dp6j10g"><img src="/cms-assets/6981e8b2bfb2cde208f4a0f17ecefc5975f7fb25c6cbe7b0171133a8715f61fb" alt="Cover page: Vitamin B12 status and hyperhomocysteinemia in patients with Rheumatoid arthritis treated with methotrexate and folic acid"/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/992849kp"><div class="c-clientmarkup">Risk of meningomyelocele mediated by the common 22q11.2 deletion.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AVong%2C%20Keng">Vong, Keng</a>; </li><li><a href="/search/?q=author%3ALee%2C%20Sangmoon">Lee, Sangmoon</a>; </li><li><a href="/search/?q=author%3AAu%2C%20Kit">Au, Kit</a>; </li><li><a href="/search/?q=author%3ACrowley%2C%20T">Crowley, T</a>; </li><li><a href="/search/?q=author%3ACapra%2C%20Valeria">Capra, Valeria</a>; </li><li><a href="/search/?q=author%3AMartino%2C%20Jeremiah">Martino, Jeremiah</a>; </li><li><a href="/search/?q=author%3AHaller%2C%20Meade">Haller, Meade</a>; </li><li><a href="/search/?q=author%3AAra%C3%BAjo%2C%20Camila">Araújo, Camila</a>; </li><li><a href="/search/?q=author%3AMachado%2C%20H%C3%A9lio">Machado, Hélio</a>; </li><li><a href="/search/?q=author%3AGeorge%2C%20Renee">George, Renee</a>; </li><li><a href="/search/?q=author%3AGerding%2C%20Bryn">Gerding, Bryn</a>; </li><li><a href="/search/?q=author%3AJames%2C%20Kiely">James, Kiely</a>; </li><li><a href="/search/?q=author%3AStanley%2C%20Valentina">Stanley, Valentina</a>; </li><li><a href="/search/?q=author%3AJiang%2C%20Nan">Jiang, Nan</a>; </li><li><a href="/search/?q=author%3AAlu%2C%20Kameron">Alu, Kameron</a>; </li><li><a href="/search/?q=author%3AMeave%2C%20Naomi">Meave, Naomi</a>; </li><li><a href="/search/?q=author%3ANidhiry%2C%20Anna">Nidhiry, Anna</a>; </li><li><a href="/search/?q=author%3AJiwani%2C%20Fiza">Jiwani, Fiza</a>; </li><li><a href="/search/?q=author%3ATang%2C%20Isaac">Tang, Isaac</a>; </li><li><a href="/search/?q=author%3ANisal%2C%20Ashna">Nisal, Ashna</a>; </li><li><a href="/search/?q=author%3AJhamb%2C%20Ishani">Jhamb, Ishani</a>; </li><li><a href="/search/?q=author%3APatel%2C%20Arzoo">Patel, Arzoo</a>; </li><li><a href="/search/?q=author%3APatel%2C%20Aakash">Patel, Aakash</a>; </li><li><a href="/search/?q=author%3AMcEvoy-Venneri%2C%20Jennifer">McEvoy-Venneri, Jennifer</a>; </li><li><a href="/search/?q=author%3ABarrows%2C%20Chelsea">Barrows, Chelsea</a>; </li><li><a href="/search/?q=author%3AShen%2C%20Celina">Shen, Celina</a>; </li><li><a href="/search/?q=author%3AHa%2C%20Yoo-Jin">Ha, Yoo-Jin</a>; </li><li><a href="/search/?q=author%3AHowarth%2C%20Robyn">Howarth, Robyn</a>; </li><li><a href="/search/?q=author%3AStrain%2C%20Madison">Strain, Madison</a>; </li><li><a href="/search/?q=author%3AAshley-Koch%2C%20Allison">Ashley-Koch, Allison</a>; </li><li><a href="/search/?q=author%3AAzam%2C%20Matloob">Azam, Matloob</a>; </li><li><a href="/search/?q=author%3AMumtaz%2C%20Sara">Mumtaz, Sara</a>; </li><li><a href="/search/?q=author%3ABot%2C%20Gyang">Bot, Gyang</a>; </li><li><a href="/search/?q=author%3AFinnell%2C%20Richard">Finnell, Richard</a>; </li><li><a href="/search/?q=author%3AKibar%2C%20Zoha">Kibar, Zoha</a>; </li><li><a href="/search/?q=author%3AMarwan%2C%20Ahmed">Marwan, Ahmed</a>; </li><li><a href="/search/?q=author%3AMelikishvili%2C%20Gia">Melikishvili, Gia</a>; </li><li><a href="/search/?q=author%3AMeltzer%2C%20Hal">Meltzer, Hal</a>; </li><li><a href="/search/?q=author%3AMutchinick%2C%20Osvaldo">Mutchinick, Osvaldo</a>; </li><li><a href="/search/?q=author%3AStevenson%2C%20David">Stevenson, David</a>; </li><li><a href="/search/?q=author%3AMroczkowski%2C%20Henry">Mroczkowski, Henry</a>; </li><li><a href="/search/?q=author%3AOstrander%2C%20Betsy">Ostrander, Betsy</a>; </li><li><a href="/search/?q=author%3ASchindewolf%2C%20Erica">Schindewolf, Erica</a>; </li><li><a href="/search/?q=author%3AMoldenhauer%2C%20Julie">Moldenhauer, Julie</a>; </li><li><a href="/search/?q=author%3AZackai%2C%20Elaine">Zackai, Elaine</a>; </li><li><a href="/search/?q=author%3AEmanuel%2C%20Beverly">Emanuel, Beverly</a>; </li><li><a href="/search/?q=author%3AGarcia-Minaur%2C%20Sixto">Garcia-Minaur, Sixto</a>; </li><li><a href="/search/?q=author%3ANowakowska%2C%20Beata">Nowakowska, Beata</a>; </li><li><a href="/search/?q=author%3AStevenson%2C%20Roger">Stevenson, Roger</a>; </li><li><a href="/search/?q=author%3AZaki%2C%20Maha">Zaki, Maha</a>; </li><li><a href="/search/?q=author%3ANorthrup%2C%20Hope">Northrup, Hope</a>; </li><li><a href="/search/?q=author%3AMcNamara%2C%20Hanna">McNamara, Hanna</a>; </li><li><a href="/search/?q=author%3AAldinger%2C%20Kimberly">Aldinger, Kimberly</a>; </li><li><a href="/search/?q=author%3APhelps%2C%20Ian">Phelps, Ian</a>; </li><li><a href="/search/?q=author%3ADeng%2C%20Mei">Deng, Mei</a>; </li><li><a href="/search/?q=author%3AGlass%2C%20Ian">Glass, Ian</a>; </li><li><a href="/search/?q=author%3AMorrow%2C%20Bernice">Morrow, Bernice</a>; </li><li><a href="/search/?q=author%3AMcDonald-McGinn%2C%20Donna">McDonald-McGinn, Donna</a>; </li><li><a href="/search/?q=author%3ASanna-Cherchi%2C%20Simone">Sanna-Cherchi, Simone</a>; </li><li><a href="/search/?q=author%3ALamb%2C%20Dolores">Lamb, Dolores</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AGleeson%2C%20Joseph">Gleeson, Joseph</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsd_postprints">UC San Diego Previously Published Works</a> (2024)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">Meningomyelocele is one of the most severe forms of neural tube defects (NTDs) and the most frequent structural birth defect of the central nervous system. We assembled the Spina Bifida Sequencing Consortium to identify causes. Exome and genome sequencing of 715 parent-offspring trios identified six patients with chromosomal 22q11.2 deletions, suggesting a 23-fold increased risk compared with the general population. Furthermore, analysis of a separate 22q11.2 deletion cohort suggested a 12- to 15-fold increased NTD risk of meningomyelocele. The loss of Crkl, one of several neural tube-expressed genes within the minimal deletion interval, was sufficient to replicate NTDs in mice, where both penetrance and expressivity were exacerbated by maternal folate deficiency. Thus, the common 22q11.2 deletion confers substantial meningomyelocele risk, which is partially alleviated by folate supplementation.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/992849kp"><img src="/cms-assets/c5b60df27ecbeb95db96ff1ad601be9cd0c96e248fc5a18ee1170fabae1bcbdc" alt="Cover page: Risk of meningomyelocele mediated by the common 22q11.2 deletion."/></a></div></section></section></main></form></div><div><div class="c-toplink"><a href="javascript:window.scrollTo(0, 0)">Top</a></div><footer class="c-footer"><nav class="c-footer__nav"><ul><li><a href="/">Home</a></li><li><a href="/aboutEschol">About eScholarship</a></li><li><a href="/campuses">Campus Sites</a></li><li><a href="/ucoapolicies">UC Open Access Policy</a></li><li><a href="/publishing">eScholarship Publishing</a></li><li><a href="https://www.cdlib.org/about/accessibility.html">Accessibility</a></li><li><a href="/privacypolicy">Privacy Statement</a></li><li><a href="/policies">Site Policies</a></li><li><a href="/terms">Terms of Use</a></li><li><a href="/login"><strong>Admin Login</strong></a></li><li><a href="https://help.escholarship.org"><strong>Help</strong></a></li></ul></nav><div class="c-footer__logo"><a href="/"><img class="c-lazyimage" data-src="/images/logo_footer-eschol.svg" alt="eScholarship, University of California"/></a></div><div class="c-footer__copyright">Powered by the<br/><a href="http://www.cdlib.org">California Digital Library</a><br/>Copyright © 2017<br/>The Regents of the University of California</div></footer></div></div></div></div> <script src="/js/vendors~app-bundle-2aefc956e545366a5d4e.js"></script> <script src="/js/app-bundle-3c8ebc2ec05dcc3202fd.js"></script> </body> </html>