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<div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">HMG14 and HMG17</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">HMG14_17</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Pfam" title="Pfam">Pfam</a></th><td class="infobox-data pfam" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/pfam/PF01101">PF01101</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/InterPro" title="InterPro">InterPro</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR000079">IPR000079</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/PROSITE" title="PROSITE">PROSITE</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://prosite.expasy.org/PDOC00307">PDOC00307</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Available protein structures:</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Pfam" title="Pfam">Pfam</a>  </th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="http://pfam.xfam.org/family/PF01101?tab=pdbBlock">structures</a> / <a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/search?kw=PF01101">ECOD</a>  </td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_annotation.annotation_id:PF01101%20AND%20rcsb_polymer_entity_annotation.type:Pfam">RCSB PDB</a>; <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?pfam_accession:PF01101">PDBe</a>; <a rel="nofollow" class="external text" href="https://pdbj.org/search/pdb?other_db_select=PFam&other_db_field=PF01101">PDBj</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PDBsum" title="PDBsum">PDBsum</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=PF01101">structure summary</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>High mobility group protein HMG14 and HMG17</b> also known as <b>nucleosomal binding domain</b> is a <a href="/wiki/Protein_family" title="Protein family">family of evolutionarily related proteins</a>. </p><p>High mobility group (HMG) proteins constitute a family of relatively low molecular weight non-<a href="/wiki/Histone" title="Histone">histone</a> components in <a href="/wiki/Chromatin" title="Chromatin">chromatin</a>. <a href="/wiki/HMGN1" title="HMGN1">HMG14</a> and <a href="/wiki/HMGN2" title="HMGN2">HMG17</a> are highly-similar proteins of about 100 amino acid residues; the sequence of chicken HMG14 is almost as similar to chicken HMG17 as it is to mammalian HMG14 polypeptides.<sup id="cite_ref-PUB00001764_1-0" class="reference"><a href="#cite_note-PUB00001764-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> The proteins bind to the inner side of the nucleosomal DNA, altering the interaction between the DNA and the <a href="/wiki/Histone_octamer" title="Histone octamer">histone octamer</a>. It is thought that they may be involved in the process that confers specific chromatin conformations to transcribable regions in the genome.<sup id="cite_ref-PUB00002433_2-0" class="reference"><a href="#cite_note-PUB00002433-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p><p>The SMART signature describes a nucleosomal binding domain, which facilitates binding of proteins to nucleosomes in chromatin. The domain is most commonly found in the high mobility group (HMG) proteins, HMG14 and HMG17, however, it is also found in other proteins which bind to nucleosomes, e.g. NBP-45. NBP-45 is a nucleosomal binding protein, first identified in mice,<sup id="cite_ref-PUB00009423_3-0" class="reference"><a href="#cite_note-PUB00009423-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> which is related to HMG14 and HMG17. NBP-45 binds specifically to nucleosome core particles, and can function as a transcriptional activator. These findings led to the suggestion that this domain, common to NBP-45, HMG14 and HMG17 is responsible for binding of the proteins to nucleosomes in chromatin. </p> <div class="mw-heading mw-heading2"><h2 id="Examples">Examples</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=High_mobility_group_protein_HMG14_and_HMG17&action=edit&section=1" title="Edit section: Examples"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Human proteins containing this domain include: </p> <ul><li><a href="/wiki/HMGN1" title="HMGN1">HMGN1</a>; <a href="/wiki/HMGN2" title="HMGN2">HMGN2</a>; <a href="/wiki/HMGN3" title="HMGN3">HMGN3</a>; <a href="/wiki/HMGN4" title="HMGN4">HMGN4</a>; <a href="/w/index.php?title=HMGN5&action=edit&redlink=1" class="new" title="HMGN5 (page does not exist)">HMGN5</a>;</li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=High_mobility_group_protein_HMG14_and_HMG17&action=edit&section=2" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-PUB00001764-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-PUB00001764_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFDodgsonBrowneBlack1988" class="citation journal cs1">Dodgson JB, Browne DL, Black AJ (1988). "Chicken chromosomal protein HMG-14 and HMG-17 cDNA clones: isolation, characterization and sequence comparison". <i>Gene</i>. <b>63</b> (2): 287–295. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0378-1119%2888%2990532-X">10.1016/0378-1119(88)90532-X</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3384337">3384337</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Chicken+chromosomal+protein+HMG-14+and+HMG-17+cDNA+clones%3A+isolation%2C+characterization+and+sequence+comparison&rft.volume=63&rft.issue=2&rft.pages=287-295&rft.date=1988&rft_id=info%3Adoi%2F10.1016%2F0378-1119%2888%2990532-X&rft_id=info%3Apmid%2F3384337&rft.aulast=Dodgson&rft.aufirst=JB&rft.au=Browne%2C+DL&rft.au=Black%2C+AJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHigh+mobility+group+protein+HMG14+and+HMG17" class="Z3988"></span></span> </li> <li id="cite_note-PUB00002433-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-PUB00002433_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGonzalezBustinLandsmanSoares1986" class="citation journal cs1">Gonzalez FJ, Bustin M, Landsman D, Soares N (1986). "Chromosomal protein HMG-17. Complete human cDNA sequence and evidence for a multigene family". <i>J. Biol. Chem</i>. <b>261</b> (16): 7479–7484. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3754870">3754870</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Chromosomal+protein+HMG-17.+Complete+human+cDNA+sequence+and+evidence+for+a+multigene+family&rft.volume=261&rft.issue=16&rft.pages=7479-7484&rft.date=1986&rft_id=info%3Apmid%2F3754870&rft.aulast=Gonzalez&rft.aufirst=FJ&rft.au=Bustin%2C+M&rft.au=Landsman%2C+D&rft.au=Soares%2C+N&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHigh+mobility+group+protein+HMG14+and+HMG17" class="Z3988"></span></span> </li> <li id="cite_note-PUB00009423-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-PUB00009423_3-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBustinLandsmanShirakawaPostnikov2000" class="citation journal cs1">Bustin M, Landsman D, Shirakawa H, Postnikov YV (2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.275.9.6368">"NBP-45, a novel nucleosomal binding protein with a tissue-specific and developmentally regulated expression"</a>. <i>J. Biol. Chem</i>. <b>275</b> (9): 6368–6374. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.275.9.6368">10.1074/jbc.275.9.6368</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10692437">10692437</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=NBP-45%2C+a+novel+nucleosomal+binding+protein+with+a+tissue-specific+and+developmentally+regulated+expression&rft.volume=275&rft.issue=9&rft.pages=6368-6374&rft.date=2000&rft_id=info%3Adoi%2F10.1074%2Fjbc.275.9.6368&rft_id=info%3Apmid%2F10692437&rft.aulast=Bustin&rft.aufirst=M&rft.au=Landsman%2C+D&rft.au=Shirakawa%2C+H&rft.au=Postnikov%2C+YV&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.275.9.6368&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHigh+mobility+group+protein+HMG14+and+HMG17" class="Z3988"></span></span> </li> </ol></div></div> <div role="note" style="font-style: italic;">This article incorporates text from the public domain <a href="/wiki/Pfam" title="Pfam">Pfam</a> and <a href="/wiki/InterPro" title="InterPro">InterPro</a>: <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR000079">IPR000079</a></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1&useformat=desktop" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=High_mobility_group_protein_HMG14_and_HMG17&oldid=1248803333">https://en.wikipedia.org/w/index.php?title=High_mobility_group_protein_HMG14_and_HMG17&oldid=1248803333</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Category</a>: <ul><li><a href="/wiki/Category:Protein_domains" title="Category:Protein domains">Protein domains</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden category: <ul><li><a href="/wiki/Category:Protein_pages_needing_a_picture" title="Category:Protein pages needing a picture">Protein pages needing a picture</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> This page was last edited on 1 October 2024, at 15:18<span class="anonymous-show"> (UTC)</span>.</li> <li id="footer-info-copyright">Text is available under the <a href="/wiki/Wikipedia:Text_of_the_Creative_Commons_Attribution-ShareAlike_4.0_International_License" title="Wikipedia:Text of the Creative Commons Attribution-ShareAlike 4.0 International License">Creative Commons Attribution-ShareAlike 4.0 License</a>; additional terms may apply. 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