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class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="33146506" href="https://www.academia.edu/Documents/in/Pathology"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/KarmelaSentija","location":"/KarmelaSentija","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/KarmelaSentija","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Pathology"]}" data-trace="false" data-dom-id="Pill-react-component-9c8fedc9-0581-480a-aef1-9730ead0e303"></div> <div id="Pill-react-component-9c8fedc9-0581-480a-aef1-9730ead0e303"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="33146506" href="https://www.academia.edu/Documents/in/Neurology"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Neurology"]}" data-trace="false" data-dom-id="Pill-react-component-67723762-e7f3-454e-b71b-71506ee8b948"></div> <div id="Pill-react-component-67723762-e7f3-454e-b71b-71506ee8b948"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Karmela Sentija</h3></div><div class="js-work-strip profile--work_container" data-work-id="115862138"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115862138/Incidencija_klamidijalne_i_HPV_infekcije_u_abnormalnim_cervikalnim_razmazima_kod_postmenopausalnih_%C5%BEena_sa_i_bez_hormonalne_nadomjesne_terapije"><img alt="Research paper thumbnail of Incidencija klamidijalne i HPV infekcije u abnormalnim cervikalnim razmazima kod postmenopausalnih žena sa i bez hormonalne nadomjesne terapije" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115862138/Incidencija_klamidijalne_i_HPV_infekcije_u_abnormalnim_cervikalnim_razmazima_kod_postmenopausalnih_%C5%BEena_sa_i_bez_hormonalne_nadomjesne_terapije">Incidencija klamidijalne i HPV infekcije u abnormalnim cervikalnim razmazima kod postmenopausalnih žena sa i bez hormonalne nadomjesne terapije</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115862138"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115862138"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115862138; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115862138]").text(description); $(".js-view-count[data-work-id=115862138]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115862138; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115862138']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115862138, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115862138]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115862138,"title":"Incidencija klamidijalne i HPV infekcije u abnormalnim cervikalnim razmazima kod postmenopausalnih žena sa i bez hormonalne nadomjesne terapije","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2002,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/115862138/Incidencija_klamidijalne_i_HPV_infekcije_u_abnormalnim_cervikalnim_razmazima_kod_postmenopausalnih_%C5%BEena_sa_i_bez_hormonalne_nadomjesne_terapije","translated_internal_url":"","created_at":"2024-03-06T02:41:20.467-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33146506,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Incidencija_klamidijalne_i_HPV_infekcije_u_abnormalnim_cervikalnim_razmazima_kod_postmenopausalnih_žena_sa_i_bez_hormonalne_nadomjesne_terapije","translated_slug":"","page_count":null,"language":"hr","content_type":"Work","owner":{"id":33146506,"first_name":"Karmela","middle_initials":null,"last_name":"Sentija","page_name":"KarmelaSentija","domain_name":"independent","created_at":"2015-07-17T14:09:02.472-07:00","display_name":"Karmela Sentija","url":"https://independent.academia.edu/KarmelaSentija"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94819823"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94819823/Acute_Myeloid_Leukemia_with_t_6_9_P23_Q34_Case_Report"><img alt="Research paper thumbnail of Acute Myeloid Leukemia with t(6 ; 9)(P23 ; Q34): Case Report" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94819823/Acute_Myeloid_Leukemia_with_t_6_9_P23_Q34_Case_Report">Acute Myeloid Leukemia with t(6 ; 9)(P23 ; Q34): Case Report</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aim: The translocation (6 ; 9)(p23 ; q34) is a rare cytogenetic aberration found in patients with...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aim: The translocation (6 ; 9)(p23 ; q34) is a rare cytogenetic aberration found in patients with acute myeloid leukemia (AML) (about 1% of all AML), and correlates with poor clinical outcome. Most patients with this disease are diagnosed with AML according to the FAB classification of M2 or M4, and many show evidence of underlying or preceding myelodysplasia. Methods: Diagnostic bone marrow samples were diagnosed by morphological, immunophenotypical criteria, and reverse transcriptase polymerase chain reaction. Chromosome studies were performed on GTG-banded chromosomes obtained from bone marrow after direct preparation or short-time cultures (24 hour). At least 20 methaphases for each sample were analyzed. FISH studies were done using BCR/ABL1 dual-color/dual_fusion probes (Kreatech, Vysys), 200 interphase nuclei (I-FISH) and on all available methaphases were analysed. Karyotypes and FISH results were described to ISCN (2009). Results: Here we describe a case of AML with t(6 ; 9)(...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94819823"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94819823"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94819823; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94819823]").text(description); $(".js-view-count[data-work-id=94819823]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94819823; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94819823']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94819823, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=94819823]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94819823,"title":"Acute Myeloid Leukemia with t(6 ; 9)(P23 ; Q34): Case Report","translated_title":"","metadata":{"abstract":"Aim: The translocation (6 ; 9)(p23 ; q34) is a rare cytogenetic aberration found in patients with acute myeloid leukemia (AML) (about 1% of all AML), and correlates with poor clinical outcome. 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That increase may serve as a marker for dysplastic and neoplastic cells of the uterine cervical epithelium. The aim of this study is to assess the p16INK4a protein expression in different stages of cytological abnormality in correlation with the proven high oncogenic risk human papillomavirus infection in order to demonstrate its value as the diagnostic marker. The study included cervical smear samples of 371 patient in whom the viral typization was done. In 171 patient, during their regular gynaecological examination, along with conventional Pap smear sampling an additional smear was taken. Two hundred cervix brush (Rovers Medical DevicesOss, the Netherlands) samples were obtained and analyzed by the LBC method and the ThinPrep2000 machine. All samples were analyzed cytologically, classified according to the Bethesda system, and immunostained wi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94819822"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94819822"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94819822; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94819822]").text(description); $(".js-view-count[data-work-id=94819822]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94819822; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94819822']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94819822, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=94819822]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94819822,"title":"[P16NIK4a expression in premalignant cervical lesions]","translated_title":"","metadata":{"abstract":"Increased expression of viral E6 and E7 oncoproteins within the host cells results in an increase in cellular protein p16INK4a expression. 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All samples were analyzed cytologically, classified according to the Bethesda system, and immunostained wi...","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti"},"translated_abstract":"Increased expression of viral E6 and E7 oncoproteins within the host cells results in an increase in cellular protein p16INK4a expression. That increase may serve as a marker for dysplastic and neoplastic cells of the uterine cervical epithelium. The aim of this study is to assess the p16INK4a protein expression in different stages of cytological abnormality in correlation with the proven high oncogenic risk human papillomavirus infection in order to demonstrate its value as the diagnostic marker. The study included cervical smear samples of 371 patient in whom the viral typization was done. In 171 patient, during their regular gynaecological examination, along with conventional Pap smear sampling an additional smear was taken. Two hundred cervix brush (Rovers Medical DevicesOss, the Netherlands) samples were obtained and analyzed by the LBC method and the ThinPrep2000 machine. 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It accounts for less t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. It accounts for less than 1% of all vulvar neoplasia and usually appears in postmenopausal women. Histologically it is analogous to Paget&#39;s disease of the breast. The most common clinical symptom is pruritus. The lesion appears as an erythematous or as an eczematous lesion with islands of hyperkeratosis. Occasionally, single anaplastic Paget&#39;s cells can be found on the vulvar smears which make cytological diagnosis of the disease possible. However, the disease can be diagnosed only by biopsy. We present a case of 49-year old woman with vulvar symptoms of pruritus, who had liver and kidney transplantation two years ago. During the standard gynecological examination the vulvar smear was taken for cytological evaluation. The smear was scanty, with inflammatory background, overloaded with squamae. There were two types of cells: dysplastic squamous cells from lower layer of the epithelium and the single, a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dac1f265e068b500c175db40ecb8c5dc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97173228,"asset_id":94819821,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97173228/download_file?st=MTczMjg0MjI2Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94819821"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94819821"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94819821; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94819821]").text(description); $(".js-view-count[data-work-id=94819821]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94819821; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94819821']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94819821, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dac1f265e068b500c175db40ecb8c5dc" } } $('.js-work-strip[data-work-id=94819821]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94819821,"title":"Vulvar Paget's disease--a case report","translated_title":"","metadata":{"abstract":"Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. It accounts for less than 1% of all vulvar neoplasia and usually appears in postmenopausal women. Histologically it is analogous to Paget\u0026#39;s disease of the breast. The most common clinical symptom is pruritus. The lesion appears as an erythematous or as an eczematous lesion with islands of hyperkeratosis. Occasionally, single anaplastic Paget\u0026#39;s cells can be found on the vulvar smears which make cytological diagnosis of the disease possible. However, the disease can be diagnosed only by biopsy. We present a case of 49-year old woman with vulvar symptoms of pruritus, who had liver and kidney transplantation two years ago. During the standard gynecological examination the vulvar smear was taken for cytological evaluation. The smear was scanty, with inflammatory background, overloaded with squamae. There were two types of cells: dysplastic squamous cells from lower layer of the epithelium and the single, a...","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Collegium antropologicum"},"translated_abstract":"Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. It accounts for less than 1% of all vulvar neoplasia and usually appears in postmenopausal women. Histologically it is analogous to Paget\u0026#39;s disease of the breast. The most common clinical symptom is pruritus. The lesion appears as an erythematous or as an eczematous lesion with islands of hyperkeratosis. Occasionally, single anaplastic Paget\u0026#39;s cells can be found on the vulvar smears which make cytological diagnosis of the disease possible. However, the disease can be diagnosed only by biopsy. We present a case of 49-year old woman with vulvar symptoms of pruritus, who had liver and kidney transplantation two years ago. During the standard gynecological examination the vulvar smear was taken for cytological evaluation. The smear was scanty, with inflammatory background, overloaded with squamae. There were two types of cells: dysplastic squamous cells from lower layer of the epithelium and the single, a...","internal_url":"https://www.academia.edu/94819821/Vulvar_Pagets_disease_a_case_report","translated_internal_url":"","created_at":"2023-01-11T22:09:00.660-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33146506,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97173228,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97173228/thumbnails/1.jpg","file_name":"85792.pdf","download_url":"https://www.academia.edu/attachments/97173228/download_file?st=MTczMjg0MjI2Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Vulvar_Pagets_disease_a_case_report.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97173228/85792-libre.pdf?1673504722=\u0026response-content-disposition=attachment%3B+filename%3DVulvar_Pagets_disease_a_case_report.pdf\u0026Expires=1732845863\u0026Signature=KGFUzAoTpzX0ICInJUzDJTYqvrvJe4RLTwv7xZoFfTxSjeVjUfchfCDwcL~JMWRaTsJ2bnhFtyCZKAXMPS2GP0Hf1Yz6NT3zRuYHegRJ46714HerlFLpvusEo5JvH2fc7TKyXauq0~uN5YRbmvkRfQoP6ueXpC4nb5qjJ~nNKyiqEroEKSXrFVf05moJoSQciCE5bO09ZICenWjVYV8orN0petuHALZeEw0TeLChYzxzhocCNF-9I1SUYwdKafxklgRH3AXMFdHNppWMwI9sQus~JOhXT9iuW3x7aedhdtHLipaw-szR5SjgReAS7EF0TLB8A14~G1c0Cpno8pXlyA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Vulvar_Pagets_disease_a_case_report","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":33146506,"first_name":"Karmela","middle_initials":null,"last_name":"Sentija","page_name":"KarmelaSentija","domain_name":"independent","created_at":"2015-07-17T14:09:02.472-07:00","display_name":"Karmela Sentija","url":"https://independent.academia.edu/KarmelaSentija"},"attachments":[{"id":97173228,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97173228/thumbnails/1.jpg","file_name":"85792.pdf","download_url":"https://www.academia.edu/attachments/97173228/download_file?st=MTczMjg0MjI2Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Vulvar_Pagets_disease_a_case_report.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97173228/85792-libre.pdf?1673504722=\u0026response-content-disposition=attachment%3B+filename%3DVulvar_Pagets_disease_a_case_report.pdf\u0026Expires=1732845863\u0026Signature=KGFUzAoTpzX0ICInJUzDJTYqvrvJe4RLTwv7xZoFfTxSjeVjUfchfCDwcL~JMWRaTsJ2bnhFtyCZKAXMPS2GP0Hf1Yz6NT3zRuYHegRJ46714HerlFLpvusEo5JvH2fc7TKyXauq0~uN5YRbmvkRfQoP6ueXpC4nb5qjJ~nNKyiqEroEKSXrFVf05moJoSQciCE5bO09ZICenWjVYV8orN0petuHALZeEw0TeLChYzxzhocCNF-9I1SUYwdKafxklgRH3AXMFdHNppWMwI9sQus~JOhXT9iuW3x7aedhdtHLipaw-szR5SjgReAS7EF0TLB8A14~G1c0Cpno8pXlyA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":165,"name":"Pathology","url":"https://www.academia.edu/Documents/in/Pathology"},{"id":767,"name":"Anthropology","url":"https://www.academia.edu/Documents/in/Anthropology"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":162159,"name":"Differential Diagnosis","url":"https://www.academia.edu/Documents/in/Differential_Diagnosis"},{"id":162554,"name":"Keratin","url":"https://www.academia.edu/Documents/in/Keratin"},{"id":3916351,"name":" Vaginal smears","url":"https://www.academia.edu/Documents/in/Vaginal_smears"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94819820"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94819820/Alcohol_sclerosing_ovarian_cystic_lesions_20_years_experience"><img alt="Research paper thumbnail of Alcohol sclerosing ovarian cystic lesions, 20 years experience" class="work-thumbnail" src="https://attachments.academia-assets.com/97173241/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94819820/Alcohol_sclerosing_ovarian_cystic_lesions_20_years_experience">Alcohol sclerosing ovarian cystic lesions, 20 years experience</a></div><div class="wp-workCard_item"><span>Collegium antropologicum</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The purpose of the study is to present technique of punction and conservative treatment of cystic...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The purpose of the study is to present technique of punction and conservative treatment of cystic ovarian lesions. The following criteria were included: 1) Cyst should be unilocular, sonolucent, with a smooth inner wall of capsule, without septa and without neovasculariation on transvaginal color and power Doppler. 2) Serum CA-125 levels must be lower than 35 U/mL. The capsule of the cyst was punctured with a 18 gauge needle under the control of 5 MHz transvaginal probe. Cyst fluid was sent for cytologic examination. After complete emptying of the cyst, we injected sterile 95% ethanol in the 50-75% of the evacuated liquor amount. The alcohol remain in the cyst from 5 to 20 minutes and was then aspirated completely. We punctured cysts in 366 patients aged from 18 to 65 years, volume of cyst being between 40 and 300 mL. Patients were monitored for 24 hours and follow-up examinations were 3, 6 and 12 months after the procedure. Three cysts were ruptured (0.8%) and alcohol split in the ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c6ef1a846af444e49a3a0b58b882c189" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97173241,"asset_id":94819820,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97173241/download_file?st=MTczMjg0MjI2Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94819820"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94819820"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94819820; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94819820]").text(description); $(".js-view-count[data-work-id=94819820]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94819820; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94819820']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94819820, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c6ef1a846af444e49a3a0b58b882c189" } } $('.js-work-strip[data-work-id=94819820]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94819820,"title":"Alcohol sclerosing ovarian cystic lesions, 20 years experience","translated_title":"","metadata":{"abstract":"The purpose of the study is to present technique of punction and conservative treatment of cystic ovarian lesions. The following criteria were included: 1) Cyst should be unilocular, sonolucent, with a smooth inner wall of capsule, without septa and without neovasculariation on transvaginal color and power Doppler. 2) Serum CA-125 levels must be lower than 35 U/mL. The capsule of the cyst was punctured with a 18 gauge needle under the control of 5 MHz transvaginal probe. Cyst fluid was sent for cytologic examination. After complete emptying of the cyst, we injected sterile 95% ethanol in the 50-75% of the evacuated liquor amount. The alcohol remain in the cyst from 5 to 20 minutes and was then aspirated completely. We punctured cysts in 366 patients aged from 18 to 65 years, volume of cyst being between 40 and 300 mL. Patients were monitored for 24 hours and follow-up examinations were 3, 6 and 12 months after the procedure. Three cysts were ruptured (0.8%) and alcohol split in the ...","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Collegium antropologicum"},"translated_abstract":"The purpose of the study is to present technique of punction and conservative treatment of cystic ovarian lesions. The following criteria were included: 1) Cyst should be unilocular, sonolucent, with a smooth inner wall of capsule, without septa and without neovasculariation on transvaginal color and power Doppler. 2) Serum CA-125 levels must be lower than 35 U/mL. The capsule of the cyst was punctured with a 18 gauge needle under the control of 5 MHz transvaginal probe. Cyst fluid was sent for cytologic examination. After complete emptying of the cyst, we injected sterile 95% ethanol in the 50-75% of the evacuated liquor amount. The alcohol remain in the cyst from 5 to 20 minutes and was then aspirated completely. We punctured cysts in 366 patients aged from 18 to 65 years, volume of cyst being between 40 and 300 mL. Patients were monitored for 24 hours and follow-up examinations were 3, 6 and 12 months after the procedure. Three cysts were ruptured (0.8%) and alcohol split in the ...","internal_url":"https://www.academia.edu/94819820/Alcohol_sclerosing_ovarian_cystic_lesions_20_years_experience","translated_internal_url":"","created_at":"2023-01-11T22:09:00.585-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33146506,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97173241,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97173241/thumbnails/1.jpg","file_name":"78491.pdf","download_url":"https://www.academia.edu/attachments/97173241/download_file?st=MTczMjg0MjI2Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Alcohol_sclerosing_ovarian_cystic_lesion.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97173241/78491-libre.pdf?1673504724=\u0026response-content-disposition=attachment%3B+filename%3DAlcohol_sclerosing_ovarian_cystic_lesion.pdf\u0026Expires=1732845863\u0026Signature=e1Ee4FmnABc~0LWG8OymP9ERPyhDxfAwx~hXhweel5CI-HRH366XvPMdwl-6HESz3TjxGJUemTn132x3G174pQuFP8oQ0f0a5JWedlXMgUn4AnLf75fZXHpxTbLg12rUxr12K27C~bf~lcDHaHch1rx8OAvo17~Em8SzSqeNm6xJqjCpxEuf6Y~wFbv~Fi5IMQNZ9gzx3BXHpdqQ7ANWnlxmNSJ3x5KBR71-G0O0OhnSbo1GcLoWDtwuro2PPiJ4Gzy71qwlxmyI~krx1YemfrwL1CvLm9u6JJjeWR2K5gRo0Idj6Nm7OSB-LSoProe41UJ0c3iwp5iiAvjoyEg9~g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Alcohol_sclerosing_ovarian_cystic_lesions_20_years_experience","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":33146506,"first_name":"Karmela","middle_initials":null,"last_name":"Sentija","page_name":"KarmelaSentija","domain_name":"independent","created_at":"2015-07-17T14:09:02.472-07:00","display_name":"Karmela Sentija","url":"https://independent.academia.edu/KarmelaSentija"},"attachments":[{"id":97173241,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97173241/thumbnails/1.jpg","file_name":"78491.pdf","download_url":"https://www.academia.edu/attachments/97173241/download_file?st=MTczMjg0MjI2Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Alcohol_sclerosing_ovarian_cystic_lesion.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97173241/78491-libre.pdf?1673504724=\u0026response-content-disposition=attachment%3B+filename%3DAlcohol_sclerosing_ovarian_cystic_lesion.pdf\u0026Expires=1732845863\u0026Signature=e1Ee4FmnABc~0LWG8OymP9ERPyhDxfAwx~hXhweel5CI-HRH366XvPMdwl-6HESz3TjxGJUemTn132x3G174pQuFP8oQ0f0a5JWedlXMgUn4AnLf75fZXHpxTbLg12rUxr12K27C~bf~lcDHaHch1rx8OAvo17~Em8SzSqeNm6xJqjCpxEuf6Y~wFbv~Fi5IMQNZ9gzx3BXHpdqQ7ANWnlxmNSJ3x5KBR71-G0O0OhnSbo1GcLoWDtwuro2PPiJ4Gzy71qwlxmyI~krx1YemfrwL1CvLm9u6JJjeWR2K5gRo0Idj6Nm7OSB-LSoProe41UJ0c3iwp5iiAvjoyEg9~g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":767,"name":"Anthropology","url":"https://www.academia.edu/Documents/in/Anthropology"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":121705,"name":"Ethanol","url":"https://www.academia.edu/Documents/in/Ethanol"},{"id":176892,"name":"Cyst","url":"https://www.academia.edu/Documents/in/Cyst"},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence"},{"id":239165,"name":"Rupture","url":"https://www.academia.edu/Documents/in/Rupture"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":379416,"name":"Epithelial cells","url":"https://www.academia.edu/Documents/in/Epithelial_cells"},{"id":612887,"name":"Capsule","url":"https://www.academia.edu/Documents/in/Capsule"},{"id":734798,"name":"Ovarian cysts","url":"https://www.academia.edu/Documents/in/Ovarian_cysts"},{"id":862505,"name":"Suction","url":"https://www.academia.edu/Documents/in/Suction"},{"id":1229542,"name":"Laparoscopy","url":"https://www.academia.edu/Documents/in/Laparoscopy"},{"id":1386611,"name":"Ovarian Cyst","url":"https://www.academia.edu/Documents/in/Ovarian_Cyst"},{"id":1450141,"name":"Needles","url":"https://www.academia.edu/Documents/in/Needles"},{"id":2416686,"name":"Laparotomy","url":"https://www.academia.edu/Documents/in/Laparotomy"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94819819"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94819819/Estimating_clinical_outcome_of_HPV_induced_cervical_lesions_by_combination_of_capsid_protein_L1_and_p16INK4a_protein_detection"><img alt="Research paper thumbnail of Estimating clinical outcome of HPV induced cervical lesions by combination of capsid protein L1 and p16INK4a protein detection" class="work-thumbnail" src="https://attachments.academia-assets.com/97173186/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94819819/Estimating_clinical_outcome_of_HPV_induced_cervical_lesions_by_combination_of_capsid_protein_L1_and_p16INK4a_protein_detection">Estimating clinical outcome of HPV induced cervical lesions by combination of capsid protein L1 and p16INK4a protein detection</a></div><div class="wp-workCard_item"><span>Collegium antropologicum</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to investigate whether is possible to predict clinical outcome of cervi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to investigate whether is possible to predict clinical outcome of cervical lesion by immunoassaying performed on cervical smears. During the two year study period the cervical smears of 81 patients were collected. All patients were tested for human papillomavirus (HPV) infections using Amplycor HPV test. Sixty-six of them were tested as positive for high risk types (hrHPV) and squamous intraepithelial lesion, and in those patients repeated cervical smears were taken every six months. The rest were hrHPV negative patients with normal smears which were used as a negative control in immunoassays with HPV L1 and p16INK4a antibodies. The results of p16INK4a staining in 66 hrHPV positive patients showed impairment of the cervical lesion in 22 (33.3%) and unchanged cytological finding in 21 (31.9%) p16INK4a positive patients, respectively, while improving of cytological finding was seen only in three (4.5%) p16LNK4a positive patients. On the contrary, impairment o...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="62c547a96fb883feda66e424412d2e97" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97173186,"asset_id":94819819,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97173186/download_file?st=MTczMjg0MjI2Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94819819"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94819819"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94819819; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94819819]").text(description); $(".js-view-count[data-work-id=94819819]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94819819; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94819819']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94819819, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "62c547a96fb883feda66e424412d2e97" } } $('.js-work-strip[data-work-id=94819819]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94819819,"title":"Estimating clinical outcome of HPV induced cervical lesions by combination of capsid protein L1 and p16INK4a protein detection","translated_title":"","metadata":{"abstract":"The aim of this study was to investigate whether is possible to predict clinical outcome of cervical lesion by immunoassaying performed on cervical smears. During the two year study period the cervical smears of 81 patients were collected. All patients were tested for human papillomavirus (HPV) infections using Amplycor HPV test. Sixty-six of them were tested as positive for high risk types (hrHPV) and squamous intraepithelial lesion, and in those patients repeated cervical smears were taken every six months. The rest were hrHPV negative patients with normal smears which were used as a negative control in immunoassays with HPV L1 and p16INK4a antibodies. The results of p16INK4a staining in 66 hrHPV positive patients showed impairment of the cervical lesion in 22 (33.3%) and unchanged cytological finding in 21 (31.9%) p16INK4a positive patients, respectively, while improving of cytological finding was seen only in three (4.5%) p16LNK4a positive patients. On the contrary, impairment o...","ai_title_tag":"Predicting Clinical Outcomes of HPV Cervical Lesions via L1 and p16","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Collegium antropologicum"},"translated_abstract":"The aim of this study was to investigate whether is possible to predict clinical outcome of cervical lesion by immunoassaying performed on cervical smears. During the two year study period the cervical smears of 81 patients were collected. All patients were tested for human papillomavirus (HPV) infections using Amplycor HPV test. Sixty-six of them were tested as positive for high risk types (hrHPV) and squamous intraepithelial lesion, and in those patients repeated cervical smears were taken every six months. The rest were hrHPV negative patients with normal smears which were used as a negative control in immunoassays with HPV L1 and p16INK4a antibodies. The results of p16INK4a staining in 66 hrHPV positive patients showed impairment of the cervical lesion in 22 (33.3%) and unchanged cytological finding in 21 (31.9%) p16INK4a positive patients, respectively, while improving of cytological finding was seen only in three (4.5%) p16LNK4a positive patients. On the contrary, impairment o...","internal_url":"https://www.academia.edu/94819819/Estimating_clinical_outcome_of_HPV_induced_cervical_lesions_by_combination_of_capsid_protein_L1_and_p16INK4a_protein_detection","translated_internal_url":"","created_at":"2023-01-11T22:09:00.507-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33146506,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97173186,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97173186/thumbnails/1.jpg","file_name":"14422397.pdf","download_url":"https://www.academia.edu/attachments/97173186/download_file?st=MTczMjg0MjI2Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Estimating_clinical_outcome_of_HPV_induc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97173186/14422397-libre.pdf?1673504729=\u0026response-content-disposition=attachment%3B+filename%3DEstimating_clinical_outcome_of_HPV_induc.pdf\u0026Expires=1732845863\u0026Signature=T2BIUofX7Yg4uP0wGDEeUAksWdl4zr7R4zNyESQoOUUoquW-aHaJa3BDznGAZtEwAC66d2Wf7iKDXVYCKJSxgfAyTcdi5O~3v2Wa5zkpomQyr8VR7KHNTqqq8WKQxHs8hYIpt7XqefnjF4D8CoqTrVF~wWPtvbKCwFxxjOU9-j-v4i9cESZib0BB6Ll3tG2IlmhtDqJuOEjq~WxGYUBB1izzCgC-z67YdTuXEXYueSMjBwb7HI5JPUbLxCShIAzHAA8xVVgoMVhlMBznNZH~P5WhfWq7~Eb6q0016jV7g5xU8Te1CxEdrw3WhasU66Q1A-D-zU4WvGENnPrGdHKHPw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Estimating_clinical_outcome_of_HPV_induced_cervical_lesions_by_combination_of_capsid_protein_L1_and_p16INK4a_protein_detection","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":33146506,"first_name":"Karmela","middle_initials":null,"last_name":"Sentija","page_name":"KarmelaSentija","domain_name":"independent","created_at":"2015-07-17T14:09:02.472-07:00","display_name":"Karmela Sentija","url":"https://independent.academia.edu/KarmelaSentija"},"attachments":[{"id":97173186,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97173186/thumbnails/1.jpg","file_name":"14422397.pdf","download_url":"https://www.academia.edu/attachments/97173186/download_file?st=MTczMjg0MjI2Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Estimating_clinical_outcome_of_HPV_induc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97173186/14422397-libre.pdf?1673504729=\u0026response-content-disposition=attachment%3B+filename%3DEstimating_clinical_outcome_of_HPV_induc.pdf\u0026Expires=1732845863\u0026Signature=T2BIUofX7Yg4uP0wGDEeUAksWdl4zr7R4zNyESQoOUUoquW-aHaJa3BDznGAZtEwAC66d2Wf7iKDXVYCKJSxgfAyTcdi5O~3v2Wa5zkpomQyr8VR7KHNTqqq8WKQxHs8hYIpt7XqefnjF4D8CoqTrVF~wWPtvbKCwFxxjOU9-j-v4i9cESZib0BB6Ll3tG2IlmhtDqJuOEjq~WxGYUBB1izzCgC-z67YdTuXEXYueSMjBwb7HI5JPUbLxCShIAzHAA8xVVgoMVhlMBznNZH~P5WhfWq7~Eb6q0016jV7g5xU8Te1CxEdrw3WhasU66Q1A-D-zU4WvGENnPrGdHKHPw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":767,"name":"Anthropology","url":"https://www.academia.edu/Documents/in/Anthropology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":50351,"name":"HUMAN PAPILLOMAVIRUS","url":"https://www.academia.edu/Documents/in/HUMAN_PAPILLOMAVIRUS"},{"id":97422,"name":"Cytology","url":"https://www.academia.edu/Documents/in/Cytology"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors"},{"id":203512,"name":"Cervical Cancer","url":"https://www.academia.edu/Documents/in/Cervical_Cancer"},{"id":315194,"name":"Oral Squamous Cell Carcinoma (OSCC)","url":"https://www.academia.edu/Documents/in/Oral_Squamous_Cell_Carcinoma_OSCC_"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis"},{"id":516411,"name":"Lesion","url":"https://www.academia.edu/Documents/in/Lesion"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1"},{"id":1199592,"name":"Cervical Intraepithelial Neoplasia","url":"https://www.academia.edu/Documents/in/Cervical_Intraepithelial_Neoplasia"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests"},{"id":3250242,"name":"Papillomavirus Infections","url":"https://www.academia.edu/Documents/in/Papillomavirus_Infections"},{"id":3658881,"name":"Uterine Cervical Neoplasms","url":"https://www.academia.edu/Documents/in/Uterine_Cervical_Neoplasms"},{"id":3916351,"name":" Vaginal smears","url":"https://www.academia.edu/Documents/in/Vaginal_smears"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94819802"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94819802/Cytogenetic_and_Morphometric_Analysis_of_Placental_Cells_in_Prenatal_Diagnostic"><img alt="Research paper thumbnail of Cytogenetic and Morphometric Analysis of Placental Cells in Prenatal Diagnostic" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94819802/Cytogenetic_and_Morphometric_Analysis_of_Placental_Cells_in_Prenatal_Diagnostic">Cytogenetic and Morphometric Analysis of Placental Cells in Prenatal Diagnostic</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: In prenatal diagnostic, placental chorionic villi biopsy (chorionic villi sampling – ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: In prenatal diagnostic, placental chorionic villi biopsy (chorionic villi sampling – CVS) is used as an invasive method for cytogenetic analysis of fetal chromosomal abnormalities. The success of cytogenetic analysis depends on the amount of villi obtained by biopsy, cultivation process, and the number of metaphases suitable for cytogenetic analysis and reliable experience of the analyzer. The procedure carries a risk of miscarriage, bleeding and other complications. Despite the high sensitivity and specificity of detection of chromosomal aberrations after chorionic villus biopsy, it is not possible in all cases to implement a reliable cytogenetic analysis, and there is a need to introduce additional methods for assessment of fetal aneuploidy. Several analyses of morphometric features of euploid and aneuploid chorionic villi have been performed in experimental models on histological samples. Due to the high incidence of chromosomal aberrations and the availability of sam...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94819802"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94819802"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94819802; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94819802]").text(description); $(".js-view-count[data-work-id=94819802]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94819802; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94819802']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94819802, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=94819802]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94819802,"title":"Cytogenetic and Morphometric Analysis of Placental Cells in Prenatal Diagnostic","translated_title":"","metadata":{"abstract":"Background: In prenatal diagnostic, placental chorionic villi biopsy (chorionic villi sampling – CVS) is used as an invasive method for cytogenetic analysis of fetal chromosomal abnormalities. The success of cytogenetic analysis depends on the amount of villi obtained by biopsy, cultivation process, and the number of metaphases suitable for cytogenetic analysis and reliable experience of the analyzer. The procedure carries a risk of miscarriage, bleeding and other complications. Despite the high sensitivity and specificity of detection of chromosomal aberrations after chorionic villus biopsy, it is not possible in all cases to implement a reliable cytogenetic analysis, and there is a need to introduce additional methods for assessment of fetal aneuploidy. Several analyses of morphometric features of euploid and aneuploid chorionic villi have been performed in experimental models on histological samples. Due to the high incidence of chromosomal aberrations and the availability of sam...","publication_date":{"day":null,"month":null,"year":2012,"errors":{}}},"translated_abstract":"Background: In prenatal diagnostic, placental chorionic villi biopsy (chorionic villi sampling – CVS) is used as an invasive method for cytogenetic analysis of fetal chromosomal abnormalities. The success of cytogenetic analysis depends on the amount of villi obtained by biopsy, cultivation process, and the number of metaphases suitable for cytogenetic analysis and reliable experience of the analyzer. The procedure carries a risk of miscarriage, bleeding and other complications. Despite the high sensitivity and specificity of detection of chromosomal aberrations after chorionic villus biopsy, it is not possible in all cases to implement a reliable cytogenetic analysis, and there is a need to introduce additional methods for assessment of fetal aneuploidy. Several analyses of morphometric features of euploid and aneuploid chorionic villi have been performed in experimental models on histological samples. Due to the high incidence of chromosomal aberrations and the availability of sam...","internal_url":"https://www.academia.edu/94819802/Cytogenetic_and_Morphometric_Analysis_of_Placental_Cells_in_Prenatal_Diagnostic","translated_internal_url":"","created_at":"2023-01-11T22:08:23.365-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33146506,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Cytogenetic_and_Morphometric_Analysis_of_Placental_Cells_in_Prenatal_Diagnostic","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33146506,"first_name":"Karmela","middle_initials":null,"last_name":"Sentija","page_name":"KarmelaSentija","domain_name":"independent","created_at":"2015-07-17T14:09:02.472-07:00","display_name":"Karmela Sentija","url":"https://independent.academia.edu/KarmelaSentija"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy"},{"id":138959,"name":"Aneuploidy","url":"https://www.academia.edu/Documents/in/Aneuploidy"},{"id":1217276,"name":"Miscarriage","url":"https://www.academia.edu/Documents/in/Miscarriage"},{"id":3544618,"name":"Chorionic villus sampling","url":"https://www.academia.edu/Documents/in/Chorionic_villus_sampling"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69205566"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/69205566/_Primary_ovarian_malignant_mixed_mesodermal_tumor_MMMT_as_a_second_primary_tumor_in_a_patient_with_invasive_breast_carcinoma_case_report_"><img alt="Research paper thumbnail of [Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/69205566/_Primary_ovarian_malignant_mixed_mesodermal_tumor_MMMT_as_a_second_primary_tumor_in_a_patient_with_invasive_breast_carcinoma_case_report_">[Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of an epithelial (carcinoma) and a stromal (sarcoma) component. MMMT accounts for less than 2% of ovarian cancers and has a very poor prognosis. We present a case and difficulties of diagnosing an ovarian MMMT in a postmenopausal woman with a history of invasive breast carcinoma treated postoperatively with radiotherapy and tamoxifen. A 52-year-old patient presented with unilateral ovarian tumor and moderately elevated CA125 (107 U/mL) and underwent laparotomy. Fine needle aspiration of the ovary and ascites for cytologic analysis, and tumor biopsy for histopathology were performed intraoperatively. Intraoperative cytologic sample showed necrotic background with rare single malignant cells with pale, abundant cytoplasm and conspicuous nucleoli suggesting clear cell carcinoma. Ascites sample showed inflammatory and reactive background with suspected papillary formations mimicking adenocarcin...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69205566"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69205566"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69205566; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69205566]").text(description); $(".js-view-count[data-work-id=69205566]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69205566; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='69205566']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 69205566, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=69205566]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":69205566,"title":"[Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]","translated_title":"","metadata":{"abstract":"Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of an epithelial (carcinoma) and a stromal (sarcoma) component. MMMT accounts for less than 2% of ovarian cancers and has a very poor prognosis. We present a case and difficulties of diagnosing an ovarian MMMT in a postmenopausal woman with a history of invasive breast carcinoma treated postoperatively with radiotherapy and tamoxifen. A 52-year-old patient presented with unilateral ovarian tumor and moderately elevated CA125 (107 U/mL) and underwent laparotomy. Fine needle aspiration of the ovary and ascites for cytologic analysis, and tumor biopsy for histopathology were performed intraoperatively. Intraoperative cytologic sample showed necrotic background with rare single malignant cells with pale, abundant cytoplasm and conspicuous nucleoli suggesting clear cell carcinoma. Ascites sample showed inflammatory and reactive background with suspected papillary formations mimicking adenocarcin...","publisher":"Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti","publication_date":{"day":null,"month":null,"year":2011,"errors":{}}},"translated_abstract":"Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of an epithelial (carcinoma) and a stromal (sarcoma) component. MMMT accounts for less than 2% of ovarian cancers and has a very poor prognosis. We present a case and difficulties of diagnosing an ovarian MMMT in a postmenopausal woman with a history of invasive breast carcinoma treated postoperatively with radiotherapy and tamoxifen. A 52-year-old patient presented with unilateral ovarian tumor and moderately elevated CA125 (107 U/mL) and underwent laparotomy. Fine needle aspiration of the ovary and ascites for cytologic analysis, and tumor biopsy for histopathology were performed intraoperatively. Intraoperative cytologic sample showed necrotic background with rare single malignant cells with pale, abundant cytoplasm and conspicuous nucleoli suggesting clear cell carcinoma. Ascites sample showed inflammatory and reactive background with suspected papillary formations mimicking adenocarcin...","internal_url":"https://www.academia.edu/69205566/_Primary_ovarian_malignant_mixed_mesodermal_tumor_MMMT_as_a_second_primary_tumor_in_a_patient_with_invasive_breast_carcinoma_case_report_","translated_internal_url":"","created_at":"2022-01-22T16:55:18.791-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33146506,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_Primary_ovarian_malignant_mixed_mesodermal_tumor_MMMT_as_a_second_primary_tumor_in_a_patient_with_invasive_breast_carcinoma_case_report_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33146506,"first_name":"Karmela","middle_initials":null,"last_name":"Sentija","page_name":"KarmelaSentija","domain_name":"independent","created_at":"2015-07-17T14:09:02.472-07:00","display_name":"Karmela Sentija","url":"https://independent.academia.edu/KarmelaSentija"},"attachments":[],"research_interests":[{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3793278,"name":"Colonic Neoplasms","url":"https://www.academia.edu/Documents/in/Colonic_Neoplasms"},{"id":3881525,"name":"Ovarian Neoplasms","url":"https://www.academia.edu/Documents/in/Ovarian_Neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="62819456"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/62819456/_Clear_cell_carcinoma_of_the_endometrium_confined_to_atrophic_endometrial_polyp_case_report_"><img alt="Research paper thumbnail of [Clear cell carcinoma of the endometrium confined to atrophic endometrial polyp--case report]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/62819456/_Clear_cell_carcinoma_of_the_endometrium_confined_to_atrophic_endometrial_polyp_case_report_">[Clear cell carcinoma of the endometrium confined to atrophic endometrial polyp--case report]</a></div><div class="wp-workCard_item"><span>Acta Medica Croatica C̆asopis Hravatske Akademije Medicinskih Znanosti</span><span>, Sep 1, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Clear cell carcinoma is a rare form of endometrial carcinoma inline type II estrogen-independent....</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Clear cell carcinoma is a rare form of endometrial carcinoma inline type II estrogen-independent. It accounts for only 1% to 5.5% of all endometrial carcinomas. It is usually detected in postmenopausal women, who are older than those with endometrioid carcinoma. Clear cell carcinoma may exhibit solid, papillary, tubular and cystic patterns. The malignant cells are characterized by a moderate amount of clear or foamy cytoplasm; however, its recognition as a clear cell type of cancer cytologically is not often possible. The tumor is usually poorly differentiated, tends to be high grade, with deep myometrial invasion, lymphovascular space invasion, and metastasis in pelvic lymph node. That is why this tumor has a poor prognosis, as in our case of a 72-year-old woman with symptoms of deficient uterine bleeding. In a period of two months, two suction endometrial curettages were performed. The material obtained by endometrial curettage for histopathologic verification was very scanty. The assessment described an inactive endometrium with degenerative epithelial cells in scanty necrotic background. Direct endometrial samples with uterobrush yielded a finding of atypical epithelial cells of open etiology with dense chromatin and prominent nucleoli, also with foam cell histiocytes and old blood in the background. Cytologic diagnosis of intraepithelial lesion, possible adenocarcinoma was made. Ultrasonography of the uterus was suspect of neoplasm. After surgery, the pathologic diagnosis of endometrial clear cell carcinoma was made. It was a rare case of aggressive type of endometrial carcinoma confined to an atrophic endometrial polyp. In conclusion, we might say that direct endometrial sample can provide accurate diagnosis of endometrial tumor, especially when the endometrial tumor is a small one, thus saving time for diagnostic testing. This is based on the potential of cytology to make malignant diagnosis possible even with a few tumor cells on the slide.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="62819456"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="62819456"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 62819456; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=62819456]").text(description); $(".js-view-count[data-work-id=62819456]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 62819456; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='62819456']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 62819456, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=62819456]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":62819456,"title":"[Clear cell carcinoma of the endometrium confined to atrophic endometrial polyp--case report]","translated_title":"","metadata":{"abstract":"Clear cell carcinoma is a rare form of endometrial carcinoma inline type II estrogen-independent. It accounts for only 1% to 5.5% of all endometrial carcinomas. It is usually detected in postmenopausal women, who are older than those with endometrioid carcinoma. Clear cell carcinoma may exhibit solid, papillary, tubular and cystic patterns. The malignant cells are characterized by a moderate amount of clear or foamy cytoplasm; however, its recognition as a clear cell type of cancer cytologically is not often possible. The tumor is usually poorly differentiated, tends to be high grade, with deep myometrial invasion, lymphovascular space invasion, and metastasis in pelvic lymph node. That is why this tumor has a poor prognosis, as in our case of a 72-year-old woman with symptoms of deficient uterine bleeding. In a period of two months, two suction endometrial curettages were performed. The material obtained by endometrial curettage for histopathologic verification was very scanty. The assessment described an inactive endometrium with degenerative epithelial cells in scanty necrotic background. Direct endometrial samples with uterobrush yielded a finding of atypical epithelial cells of open etiology with dense chromatin and prominent nucleoli, also with foam cell histiocytes and old blood in the background. Cytologic diagnosis of intraepithelial lesion, possible adenocarcinoma was made. Ultrasonography of the uterus was suspect of neoplasm. After surgery, the pathologic diagnosis of endometrial clear cell carcinoma was made. It was a rare case of aggressive type of endometrial carcinoma confined to an atrophic endometrial polyp. In conclusion, we might say that direct endometrial sample can provide accurate diagnosis of endometrial tumor, especially when the endometrial tumor is a small one, thus saving time for diagnostic testing. This is based on the potential of cytology to make malignant diagnosis possible even with a few tumor cells on the slide.","publication_date":{"day":1,"month":9,"year":2011,"errors":{}},"publication_name":"Acta Medica Croatica C̆asopis Hravatske Akademije Medicinskih Znanosti"},"translated_abstract":"Clear cell carcinoma is a rare form of endometrial carcinoma inline type II estrogen-independent. It accounts for only 1% to 5.5% of all endometrial carcinomas. It is usually detected in postmenopausal women, who are older than those with endometrioid carcinoma. Clear cell carcinoma may exhibit solid, papillary, tubular and cystic patterns. The malignant cells are characterized by a moderate amount of clear or foamy cytoplasm; however, its recognition as a clear cell type of cancer cytologically is not often possible. The tumor is usually poorly differentiated, tends to be high grade, with deep myometrial invasion, lymphovascular space invasion, and metastasis in pelvic lymph node. That is why this tumor has a poor prognosis, as in our case of a 72-year-old woman with symptoms of deficient uterine bleeding. In a period of two months, two suction endometrial curettages were performed. The material obtained by endometrial curettage for histopathologic verification was very scanty. The assessment described an inactive endometrium with degenerative epithelial cells in scanty necrotic background. Direct endometrial samples with uterobrush yielded a finding of atypical epithelial cells of open etiology with dense chromatin and prominent nucleoli, also with foam cell histiocytes and old blood in the background. Cytologic diagnosis of intraepithelial lesion, possible adenocarcinoma was made. Ultrasonography of the uterus was suspect of neoplasm. After surgery, the pathologic diagnosis of endometrial clear cell carcinoma was made. It was a rare case of aggressive type of endometrial carcinoma confined to an atrophic endometrial polyp. In conclusion, we might say that direct endometrial sample can provide accurate diagnosis of endometrial tumor, especially when the endometrial tumor is a small one, thus saving time for diagnostic testing. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="62819455"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/62819455/Pra%C4%87enje_kromosomskih_aberacija_u_medicinskog_osoblja_profesionalno_izlo%C5%BEenog_djelovanju_rendgenskih_zrka"><img alt="Research paper thumbnail of Praćenje kromosomskih aberacija u medicinskog osoblja profesionalno izloženog djelovanju rendgenskih zrka" class="work-thumbnail" src="https://attachments.academia-assets.com/75465323/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/62819455/Pra%C4%87enje_kromosomskih_aberacija_u_medicinskog_osoblja_profesionalno_izlo%C5%BEenog_djelovanju_rendgenskih_zrka">Praćenje kromosomskih aberacija u medicinskog osoblja profesionalno izloženog djelovanju rendgenskih zrka</a></div><div class="wp-workCard_item"><span>Arhiv Za Higijenu Rada I Toksikologiju</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="63df8227a5a14fc0d2a36c674994ff3c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":75465323,"asset_id":62819455,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/75465323/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="62819455"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="62819455"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 62819455; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="62819454"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/62819454/Chromosome_aberrations_in_peripheral_blood_lymphocytes_from_control_individuals"><img alt="Research paper thumbnail of Chromosome aberrations in peripheral blood lymphocytes from control individuals" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/62819454/Chromosome_aberrations_in_peripheral_blood_lymphocytes_from_control_individuals">Chromosome aberrations in peripheral blood lymphocytes from control individuals</a></div><div class="wp-workCard_item"><span>Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis</span><span>, Apr 30, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Bender et al., 1989. MA Bender, RJ Preston, RC Leonard, BE Pyatt and PC Gooch , Chromosomal a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Bender et al., 1989. MA Bender, RJ Preston, RC Leonard, BE Pyatt and PC Gooch , Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human populatiion sample. In: II. ... 149154. Abstract | PDF (455 K). Evan, 1979. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="62819454"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="62819454"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 62819454; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=62819454]").text(description); $(".js-view-count[data-work-id=62819454]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 62819454; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='62819454']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 62819454, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=62819454]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":62819454,"title":"Chromosome aberrations in peripheral blood lymphocytes from control individuals","translated_title":"","metadata":{"abstract":"... 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="62819354"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/62819354/Cytogenetic_changes_in_subjects_occupationally_exposed_to_benzene"><img alt="Research paper thumbnail of Cytogenetic changes in subjects occupationally exposed to benzene" class="work-thumbnail" src="https://attachments.academia-assets.com/75465370/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/62819354/Cytogenetic_changes_in_subjects_occupationally_exposed_to_benzene">Cytogenetic changes in subjects occupationally exposed to benzene</a></div><div class="wp-workCard_item"><span>Chemosphere</span><span>, 2000</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bbc2d120ceea6a2c0cad05db0140e264" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":75465370,"asset_id":62819354,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/75465370/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="62819354"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="62819354"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 62819354; 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The genotoxic eects of benzene were assessed in peripheral blood lymphocytes of 36 workers employed in the shoe industry for a period extending from seven months to over 30 years. Chromosomal aberrations and sister chromatide exchanges were used as indicators of genotoxic eects. The incidence of dicentric chromosomes in the exposed group was signi®cantly higher than in the control group (P \u003c 0.05). No signi®cant increase was detected between the working period in the exposed group and chromosomal aberrations. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14023750"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14023750/_Primary_ovarian_malignant_mixed_mesodermal_tumor_MMMT_as_a_second_primary_tumor_in_a_patient_with_invasive_breast_carcinoma_case_report_"><img alt="Research paper thumbnail of [Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14023750/_Primary_ovarian_malignant_mixed_mesodermal_tumor_MMMT_as_a_second_primary_tumor_in_a_patient_with_invasive_breast_carcinoma_case_report_">[Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/KarmelaSentija">Karmela Sentija</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://mef.academia.edu/VlastimirKukura">Vlastimir Kukura</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://mef.academia.edu/SlavkoGasparov">Slavko Gasparov</a></span></div><div class="wp-workCard_item"><span>Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of an epithelial (carcinoma) and a stromal (sarcoma) component. MMMT accounts for less than 2% of ovarian cancers and has a very poor prognosis. We present a case and difficulties of diagnosing an ovarian MMMT in a postmenopausal woman with a history of invasive breast carcinoma treated postoperatively with radiotherapy and tamoxifen. A 52-year-old patient presented with unilateral ovarian tumor and moderately elevated CA125 (107 U/mL) and underwent laparotomy. Fine needle aspiration of the ovary and ascites for cytologic analysis, and tumor biopsy for histopathology were performed intraoperatively. Intraoperative cytologic sample showed necrotic background with rare single malignant cells with pale, abundant cytoplasm and conspicuous nucleoli suggesting clear cell carcinoma. Ascites sample showed inflammatory and reactive background with suspected papillary formations mimicking adenocarcin...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14023750"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14023750"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14023750; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14023750]").text(description); $(".js-view-count[data-work-id=14023750]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14023750; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14023750']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 14023750, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14023750]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14023750,"title":"[Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]","translated_title":"","metadata":{"abstract":"Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of an epithelial (carcinoma) and a stromal (sarcoma) component. MMMT accounts for less than 2% of ovarian cancers and has a very poor prognosis. We present a case and difficulties of diagnosing an ovarian MMMT in a postmenopausal woman with a history of invasive breast carcinoma treated postoperatively with radiotherapy and tamoxifen. A 52-year-old patient presented with unilateral ovarian tumor and moderately elevated CA125 (107 U/mL) and underwent laparotomy. Fine needle aspiration of the ovary and ascites for cytologic analysis, and tumor biopsy for histopathology were performed intraoperatively. Intraoperative cytologic sample showed necrotic background with rare single malignant cells with pale, abundant cytoplasm and conspicuous nucleoli suggesting clear cell carcinoma. Ascites sample showed inflammatory and reactive background with suspected papillary formations mimicking adenocarcin...","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti"},"translated_abstract":"Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of an epithelial (carcinoma) and a stromal (sarcoma) component. MMMT accounts for less than 2% of ovarian cancers and has a very poor prognosis. We present a case and difficulties of diagnosing an ovarian MMMT in a postmenopausal woman with a history of invasive breast carcinoma treated postoperatively with radiotherapy and tamoxifen. A 52-year-old patient presented with unilateral ovarian tumor and moderately elevated CA125 (107 U/mL) and underwent laparotomy. Fine needle aspiration of the ovary and ascites for cytologic analysis, and tumor biopsy for histopathology were performed intraoperatively. Intraoperative cytologic sample showed necrotic background with rare single malignant cells with pale, abundant cytoplasm and conspicuous nucleoli suggesting clear cell carcinoma. Ascites sample showed inflammatory and reactive background with suspected papillary formations mimicking adenocarcin...","internal_url":"https://www.academia.edu/14023750/_Primary_ovarian_malignant_mixed_mesodermal_tumor_MMMT_as_a_second_primary_tumor_in_a_patient_with_invasive_breast_carcinoma_case_report_","translated_internal_url":"","created_at":"2015-07-14T02:49:15.179-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33053887,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":3101117,"work_id":14023750,"tagging_user_id":33053887,"tagged_user_id":33146506,"co_author_invite_id":784437,"email":"k***a@yahoo.com","display_order":0,"name":"Karmela Sentija","title":"[Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]"},{"id":3101124,"work_id":14023750,"tagging_user_id":33053887,"tagged_user_id":null,"co_author_invite_id":784439,"email":"s***a@centrum.cz","display_order":4194304,"name":"Suzana Simon","title":"[Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]"},{"id":3101128,"work_id":14023750,"tagging_user_id":33053887,"tagged_user_id":33137034,"co_author_invite_id":784440,"email":"g***o@gmail.com","affiliation":"University of medicine Zagreb","display_order":6291456,"name":"Slavko Gasparov","title":"[Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]"}],"downloadable_attachments":[],"slug":"_Primary_ovarian_malignant_mixed_mesodermal_tumor_MMMT_as_a_second_primary_tumor_in_a_patient_with_invasive_breast_carcinoma_case_report_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33053887,"first_name":"Vlastimir","middle_initials":null,"last_name":"Kukura","page_name":"VlastimirKukura","domain_name":"mef","created_at":"2015-07-14T02:44:43.319-07:00","display_name":"Vlastimir Kukura","url":"https://mef.academia.edu/VlastimirKukura"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14023749"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14023749/_P16NIK4a_expression_in_premalignant_cervical_lesions_"><img alt="Research paper thumbnail of [P16NIK4a expression in premalignant cervical lesions]" class="work-thumbnail" src="https://attachments.academia-assets.com/44695056/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14023749/_P16NIK4a_expression_in_premalignant_cervical_lesions_">[P16NIK4a expression in premalignant cervical lesions]</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/KarmelaSentija">Karmela Sentija</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://mef.academia.edu/VlastimirKukura">Vlastimir Kukura</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unizg.academia.edu/JasminaVranes">Jasmina Vranes</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MarinaPa%C5%BEur">Marina Pažur</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/KatalenicSuzana">Katalenic Suzana</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ZeljkoDui%C4%87">Zeljko Duić</a></span></div><div class="wp-workCard_item"><span>Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Increased expression of viral E6 and E7 oncoproteins within the host cells results in an increase...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Increased expression of viral E6 and E7 oncoproteins within the host cells results in an increase in cellular protein p16INK4a expression. That increase may serve as a marker for dysplastic and neoplastic cells of the uterine cervical epithelium. The aim of this study is to assess the p16INK4a protein expression in different stages of cytological abnormality in correlation with the proven high oncogenic risk human papillomavirus infection in order to demonstrate its value as the diagnostic marker. The study included cervical smear samples of 371 patient in whom the viral typization was done. In 171 patient, during their regular gynaecological examination, along with conventional Pap smear sampling an additional smear was taken. Two hundred cervix brush (Rovers Medical DevicesOss, the Netherlands) samples were obtained and analyzed by the LBC method and the ThinPrep2000 machine. All samples were analyzed cytologically, classified according to the Bethesda system, and immunostained wi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="28540d75730a2a1af71ac246d7f74877" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44695056,"asset_id":14023749,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44695056/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14023749"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14023749"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14023749; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14023749]").text(description); $(".js-view-count[data-work-id=14023749]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14023749; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14023749']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 14023749, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "28540d75730a2a1af71ac246d7f74877" } } $('.js-work-strip[data-work-id=14023749]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14023749,"title":"[P16NIK4a expression in premalignant cervical lesions]","translated_title":"","metadata":{"abstract":"Increased expression of viral E6 and E7 oncoproteins within the host cells results in an increase in cellular protein p16INK4a expression. 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All samples were analyzed cytologically, classified according to the Bethesda system, and immunostained wi...","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti"},"translated_abstract":"Increased expression of viral E6 and E7 oncoproteins within the host cells results in an increase in cellular protein p16INK4a expression. That increase may serve as a marker for dysplastic and neoplastic cells of the uterine cervical epithelium. The aim of this study is to assess the p16INK4a protein expression in different stages of cytological abnormality in correlation with the proven high oncogenic risk human papillomavirus infection in order to demonstrate its value as the diagnostic marker. The study included cervical smear samples of 371 patient in whom the viral typization was done. 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text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14023748/Vulvar_Pagets_disease_a_case_report">Vulvar Paget's disease--a case report</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/KarmelaSentija">Karmela Sentija</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://mef.academia.edu/VlastimirKukura">Vlastimir Kukura</a></span></div><div class="wp-workCard_item"><span>Collegium antropologicum</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. It accounts for less t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. It accounts for less than 1% of all vulvar neoplasia and usually appears in postmenopausal women. Histologically it is analogous to Paget&#39;s disease of the breast. The most common clinical symptom is pruritus. The lesion appears as an erythematous or as an eczematous lesion with islands of hyperkeratosis. Occasionally, single anaplastic Paget&#39;s cells can be found on the vulvar smears which make cytological diagnosis of the disease possible. However, the disease can be diagnosed only by biopsy. We present a case of 49-year old woman with vulvar symptoms of pruritus, who had liver and kidney transplantation two years ago. During the standard gynecological examination the vulvar smear was taken for cytological evaluation. The smear was scanty, with inflammatory background, overloaded with squamae. There were two types of cells: dysplastic squamous cells from lower layer of the epithelium and the single, a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="590c258c364281e8a5a82000997bd2c5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44695026,"asset_id":14023748,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44695026/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14023748"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14023748"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14023748; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14023748]").text(description); $(".js-view-count[data-work-id=14023748]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14023748; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14023748']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 14023748, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "590c258c364281e8a5a82000997bd2c5" } } $('.js-work-strip[data-work-id=14023748]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14023748,"title":"Vulvar Paget's disease--a case report","translated_title":"","metadata":{"abstract":"Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. 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There were two types of cells: dysplastic squamous cells from lower layer of the epithelium and the single, a...","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Collegium antropologicum"},"translated_abstract":"Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. It accounts for less than 1% of all vulvar neoplasia and usually appears in postmenopausal women. Histologically it is analogous to Paget\u0026#39;s disease of the breast. The most common clinical symptom is pruritus. The lesion appears as an erythematous or as an eczematous lesion with islands of hyperkeratosis. Occasionally, single anaplastic Paget\u0026#39;s cells can be found on the vulvar smears which make cytological diagnosis of the disease possible. However, the disease can be diagnosed only by biopsy. We present a case of 49-year old woman with vulvar symptoms of pruritus, who had liver and kidney transplantation two years ago. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14023747"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14023747/Alcohol_sclerosing_ovarian_cystic_lesions_20_years_experience"><img alt="Research paper thumbnail of Alcohol sclerosing ovarian cystic lesions, 20 years experience" class="work-thumbnail" src="https://attachments.academia-assets.com/44695035/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14023747/Alcohol_sclerosing_ovarian_cystic_lesions_20_years_experience">Alcohol sclerosing ovarian cystic lesions, 20 years experience</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/KarmelaSentija">Karmela Sentija</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://mef.academia.edu/VlastimirKukura">Vlastimir Kukura</a></span></div><div class="wp-workCard_item"><span>Collegium antropologicum</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The purpose of the study is to present technique of punction and conservative treatment of cystic...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The purpose of the study is to present technique of punction and conservative treatment of cystic ovarian lesions. The following criteria were included: 1) Cyst should be unilocular, sonolucent, with a smooth inner wall of capsule, without septa and without neovasculariation on transvaginal color and power Doppler. 2) Serum CA-125 levels must be lower than 35 U/mL. The capsule of the cyst was punctured with a 18 gauge needle under the control of 5 MHz transvaginal probe. Cyst fluid was sent for cytologic examination. After complete emptying of the cyst, we injected sterile 95% ethanol in the 50-75% of the evacuated liquor amount. The alcohol remain in the cyst from 5 to 20 minutes and was then aspirated completely. We punctured cysts in 366 patients aged from 18 to 65 years, volume of cyst being between 40 and 300 mL. Patients were monitored for 24 hours and follow-up examinations were 3, 6 and 12 months after the procedure. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14160331"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14160331/Radiation_induced_chromosomal_aberrations_and_haematological_alterations_in_hospital_workers"><img alt="Research paper thumbnail of Radiation-induced chromosomal aberrations and haematological alterations in hospital workers" class="work-thumbnail" src="https://attachments.academia-assets.com/44553144/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14160331/Radiation_induced_chromosomal_aberrations_and_haematological_alterations_in_hospital_workers">Radiation-induced chromosomal aberrations and haematological alterations in hospital workers</a></div><div class="wp-workCard_item"><span>Occupational Medicine</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0c564c7d0c93a57804c37bfb57715d07" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44553144,"asset_id":14160331,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44553144/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14160331"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14160331"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14160331; 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wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14023746/Estimating_clinical_outcome_of_HPV_induced_cervical_lesions_by_combination_of_capsid_protein_L1_and_p16INK4a_protein_detection">Estimating clinical outcome of HPV induced cervical lesions by combination of capsid protein L1 and p16INK4a protein detection</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/KarmelaSentija">Karmela Sentija</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://mef.academia.edu/VlastimirKukura">Vlastimir Kukura</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unizg.academia.edu/JasminaVranes">Jasmina Vranes</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/InesBolanca">Ines Bolanča</a></span></div><div class="wp-workCard_item"><span>Collegium antropologicum</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to investigate whether is possible to predict clinical outcome of cervi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to investigate whether is possible to predict clinical outcome of cervical lesion by immunoassaying performed on cervical smears. During the two year study period the cervical smears of 81 patients were collected. All patients were tested for human papillomavirus (HPV) infections using Amplycor HPV test. Sixty-six of them were tested as positive for high risk types (hrHPV) and squamous intraepithelial lesion, and in those patients repeated cervical smears were taken every six months. The rest were hrHPV negative patients with normal smears which were used as a negative control in immunoassays with HPV L1 and p16INK4a antibodies. The results of p16INK4a staining in 66 hrHPV positive patients showed impairment of the cervical lesion in 22 (33.3%) and unchanged cytological finding in 21 (31.9%) p16INK4a positive patients, respectively, while improving of cytological finding was seen only in three (4.5%) p16LNK4a positive patients. On the contrary, impairment o...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="937b4b901ea4c00149c8db81d05f74fa" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44695032,"asset_id":14023746,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44695032/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14023746"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14023746"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14023746; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14023746]").text(description); $(".js-view-count[data-work-id=14023746]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14023746; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14023746']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 14023746, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "937b4b901ea4c00149c8db81d05f74fa" } } $('.js-work-strip[data-work-id=14023746]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14023746,"title":"Estimating clinical outcome of HPV induced cervical lesions by combination of capsid protein L1 and p16INK4a protein detection","translated_title":"","metadata":{"abstract":"The aim of this study was to investigate whether is possible to predict clinical outcome of cervical lesion by immunoassaying performed on cervical smears. 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data-section-id="3239727" id="papers"><div class="js-work-strip profile--work_container" data-work-id="115862138"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115862138/Incidencija_klamidijalne_i_HPV_infekcije_u_abnormalnim_cervikalnim_razmazima_kod_postmenopausalnih_%C5%BEena_sa_i_bez_hormonalne_nadomjesne_terapije"><img alt="Research paper thumbnail of Incidencija klamidijalne i HPV infekcije u abnormalnim cervikalnim razmazima kod postmenopausalnih žena sa i bez hormonalne nadomjesne terapije" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115862138/Incidencija_klamidijalne_i_HPV_infekcije_u_abnormalnim_cervikalnim_razmazima_kod_postmenopausalnih_%C5%BEena_sa_i_bez_hormonalne_nadomjesne_terapije">Incidencija klamidijalne i HPV infekcije u abnormalnim cervikalnim razmazima kod postmenopausalnih žena sa i bez hormonalne nadomjesne terapije</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115862138"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115862138"><i 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text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94819823/Acute_Myeloid_Leukemia_with_t_6_9_P23_Q34_Case_Report">Acute Myeloid Leukemia with t(6 ; 9)(P23 ; Q34): Case Report</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aim: The translocation (6 ; 9)(p23 ; q34) is a rare cytogenetic aberration found in patients with...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aim: The translocation (6 ; 9)(p23 ; q34) is a rare cytogenetic aberration found in patients with acute myeloid leukemia (AML) (about 1% of all AML), and correlates with poor clinical outcome. Most patients with this disease are diagnosed with AML according to the FAB classification of M2 or M4, and many show evidence of underlying or preceding myelodysplasia. Methods: Diagnostic bone marrow samples were diagnosed by morphological, immunophenotypical criteria, and reverse transcriptase polymerase chain reaction. Chromosome studies were performed on GTG-banded chromosomes obtained from bone marrow after direct preparation or short-time cultures (24 hour). At least 20 methaphases for each sample were analyzed. FISH studies were done using BCR/ABL1 dual-color/dual_fusion probes (Kreatech, Vysys), 200 interphase nuclei (I-FISH) and on all available methaphases were analysed. Karyotypes and FISH results were described to ISCN (2009). Results: Here we describe a case of AML with t(6 ; 9)(...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94819823"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94819823"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94819823; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94819823]").text(description); $(".js-view-count[data-work-id=94819823]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94819823; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94819823']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94819823, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=94819823]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94819823,"title":"Acute Myeloid Leukemia with t(6 ; 9)(P23 ; Q34): Case Report","translated_title":"","metadata":{"abstract":"Aim: The translocation (6 ; 9)(p23 ; q34) is a rare cytogenetic aberration found in patients with acute myeloid leukemia (AML) (about 1% of all AML), and correlates with poor clinical outcome. 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That increase may serve as a marker for dysplastic and neoplastic cells of the uterine cervical epithelium. The aim of this study is to assess the p16INK4a protein expression in different stages of cytological abnormality in correlation with the proven high oncogenic risk human papillomavirus infection in order to demonstrate its value as the diagnostic marker. The study included cervical smear samples of 371 patient in whom the viral typization was done. In 171 patient, during their regular gynaecological examination, along with conventional Pap smear sampling an additional smear was taken. Two hundred cervix brush (Rovers Medical DevicesOss, the Netherlands) samples were obtained and analyzed by the LBC method and the ThinPrep2000 machine. All samples were analyzed cytologically, classified according to the Bethesda system, and immunostained wi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94819822"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94819822"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94819822; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94819822]").text(description); $(".js-view-count[data-work-id=94819822]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94819822; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94819822']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94819822, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=94819822]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94819822,"title":"[P16NIK4a expression in premalignant cervical lesions]","translated_title":"","metadata":{"abstract":"Increased expression of viral E6 and E7 oncoproteins within the host cells results in an increase in cellular protein p16INK4a expression. That increase may serve as a marker for dysplastic and neoplastic cells of the uterine cervical epithelium. The aim of this study is to assess the p16INK4a protein expression in different stages of cytological abnormality in correlation with the proven high oncogenic risk human papillomavirus infection in order to demonstrate its value as the diagnostic marker. The study included cervical smear samples of 371 patient in whom the viral typization was done. In 171 patient, during their regular gynaecological examination, along with conventional Pap smear sampling an additional smear was taken. Two hundred cervix brush (Rovers Medical DevicesOss, the Netherlands) samples were obtained and analyzed by the LBC method and the ThinPrep2000 machine. All samples were analyzed cytologically, classified according to the Bethesda system, and immunostained wi...","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti"},"translated_abstract":"Increased expression of viral E6 and E7 oncoproteins within the host cells results in an increase in cellular protein p16INK4a expression. That increase may serve as a marker for dysplastic and neoplastic cells of the uterine cervical epithelium. The aim of this study is to assess the p16INK4a protein expression in different stages of cytological abnormality in correlation with the proven high oncogenic risk human papillomavirus infection in order to demonstrate its value as the diagnostic marker. The study included cervical smear samples of 371 patient in whom the viral typization was done. In 171 patient, during their regular gynaecological examination, along with conventional Pap smear sampling an additional smear was taken. Two hundred cervix brush (Rovers Medical DevicesOss, the Netherlands) samples were obtained and analyzed by the LBC method and the ThinPrep2000 machine. All samples were analyzed cytologically, classified according to the Bethesda system, and immunostained wi...","internal_url":"https://www.academia.edu/94819822/_P16NIK4a_expression_in_premalignant_cervical_lesions_","translated_internal_url":"","created_at":"2023-01-11T22:09:00.739-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33146506,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_P16NIK4a_expression_in_premalignant_cervical_lesions_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33146506,"first_name":"Karmela","middle_initials":null,"last_name":"Sentija","page_name":"KarmelaSentija","domain_name":"independent","created_at":"2015-07-17T14:09:02.472-07:00","display_name":"Karmela Sentija","url":"https://independent.academia.edu/KarmelaSentija"},"attachments":[],"research_interests":[{"id":165,"name":"Pathology","url":"https://www.academia.edu/Documents/in/Pathology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":50351,"name":"HUMAN PAPILLOMAVIRUS","url":"https://www.academia.edu/Documents/in/HUMAN_PAPILLOMAVIRUS"},{"id":372616,"name":"Dysplasia","url":"https://www.academia.edu/Documents/in/Dysplasia"},{"id":375142,"name":"Precancerous Conditions","url":"https://www.academia.edu/Documents/in/Precancerous_Conditions"},{"id":1199592,"name":"Cervical Intraepithelial Neoplasia","url":"https://www.academia.edu/Documents/in/Cervical_Intraepithelial_Neoplasia"},{"id":1509043,"name":"HPV Infection","url":"https://www.academia.edu/Documents/in/HPV_Infection"},{"id":3250242,"name":"Papillomavirus Infections","url":"https://www.academia.edu/Documents/in/Papillomavirus_Infections"},{"id":3658881,"name":"Uterine Cervical Neoplasms","url":"https://www.academia.edu/Documents/in/Uterine_Cervical_Neoplasms"},{"id":3746613,"name":"Papanicolaou test","url":"https://www.academia.edu/Documents/in/Papanicolaou_test"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3916351,"name":" Vaginal smears","url":"https://www.academia.edu/Documents/in/Vaginal_smears"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94819821"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94819821/Vulvar_Pagets_disease_a_case_report"><img alt="Research paper thumbnail of Vulvar Paget's disease--a case report" class="work-thumbnail" src="https://attachments.academia-assets.com/97173228/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94819821/Vulvar_Pagets_disease_a_case_report">Vulvar Paget's disease--a case report</a></div><div class="wp-workCard_item"><span>Collegium antropologicum</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. It accounts for less t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. It accounts for less than 1% of all vulvar neoplasia and usually appears in postmenopausal women. Histologically it is analogous to Paget&#39;s disease of the breast. The most common clinical symptom is pruritus. The lesion appears as an erythematous or as an eczematous lesion with islands of hyperkeratosis. Occasionally, single anaplastic Paget&#39;s cells can be found on the vulvar smears which make cytological diagnosis of the disease possible. However, the disease can be diagnosed only by biopsy. We present a case of 49-year old woman with vulvar symptoms of pruritus, who had liver and kidney transplantation two years ago. During the standard gynecological examination the vulvar smear was taken for cytological evaluation. The smear was scanty, with inflammatory background, overloaded with squamae. There were two types of cells: dysplastic squamous cells from lower layer of the epithelium and the single, a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dac1f265e068b500c175db40ecb8c5dc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97173228,"asset_id":94819821,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97173228/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&st=MTczMjg0MjI2Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94819821"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94819821"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94819821; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94819821]").text(description); $(".js-view-count[data-work-id=94819821]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94819821; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94819821']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94819821, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dac1f265e068b500c175db40ecb8c5dc" } } $('.js-work-strip[data-work-id=94819821]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94819821,"title":"Vulvar Paget's disease--a case report","translated_title":"","metadata":{"abstract":"Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. It accounts for less than 1% of all vulvar neoplasia and usually appears in postmenopausal women. Histologically it is analogous to Paget\u0026#39;s disease of the breast. The most common clinical symptom is pruritus. The lesion appears as an erythematous or as an eczematous lesion with islands of hyperkeratosis. Occasionally, single anaplastic Paget\u0026#39;s cells can be found on the vulvar smears which make cytological diagnosis of the disease possible. However, the disease can be diagnosed only by biopsy. We present a case of 49-year old woman with vulvar symptoms of pruritus, who had liver and kidney transplantation two years ago. During the standard gynecological examination the vulvar smear was taken for cytological evaluation. The smear was scanty, with inflammatory background, overloaded with squamae. There were two types of cells: dysplastic squamous cells from lower layer of the epithelium and the single, a...","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Collegium antropologicum"},"translated_abstract":"Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. It accounts for less than 1% of all vulvar neoplasia and usually appears in postmenopausal women. Histologically it is analogous to Paget\u0026#39;s disease of the breast. The most common clinical symptom is pruritus. The lesion appears as an erythematous or as an eczematous lesion with islands of hyperkeratosis. Occasionally, single anaplastic Paget\u0026#39;s cells can be found on the vulvar smears which make cytological diagnosis of the disease possible. However, the disease can be diagnosed only by biopsy. We present a case of 49-year old woman with vulvar symptoms of pruritus, who had liver and kidney transplantation two years ago. During the standard gynecological examination the vulvar smear was taken for cytological evaluation. The smear was scanty, with inflammatory background, overloaded with squamae. There were two types of cells: dysplastic squamous cells from lower layer of the epithelium and the single, a...","internal_url":"https://www.academia.edu/94819821/Vulvar_Pagets_disease_a_case_report","translated_internal_url":"","created_at":"2023-01-11T22:09:00.660-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33146506,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97173228,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97173228/thumbnails/1.jpg","file_name":"85792.pdf","download_url":"https://www.academia.edu/attachments/97173228/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&st=MTczMjg0MjI2Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Vulvar_Pagets_disease_a_case_report.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97173228/85792-libre.pdf?1673504722=\u0026response-content-disposition=attachment%3B+filename%3DVulvar_Pagets_disease_a_case_report.pdf\u0026Expires=1732845863\u0026Signature=KGFUzAoTpzX0ICInJUzDJTYqvrvJe4RLTwv7xZoFfTxSjeVjUfchfCDwcL~JMWRaTsJ2bnhFtyCZKAXMPS2GP0Hf1Yz6NT3zRuYHegRJ46714HerlFLpvusEo5JvH2fc7TKyXauq0~uN5YRbmvkRfQoP6ueXpC4nb5qjJ~nNKyiqEroEKSXrFVf05moJoSQciCE5bO09ZICenWjVYV8orN0petuHALZeEw0TeLChYzxzhocCNF-9I1SUYwdKafxklgRH3AXMFdHNppWMwI9sQus~JOhXT9iuW3x7aedhdtHLipaw-szR5SjgReAS7EF0TLB8A14~G1c0Cpno8pXlyA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Vulvar_Pagets_disease_a_case_report","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":33146506,"first_name":"Karmela","middle_initials":null,"last_name":"Sentija","page_name":"KarmelaSentija","domain_name":"independent","created_at":"2015-07-17T14:09:02.472-07:00","display_name":"Karmela Sentija","url":"https://independent.academia.edu/KarmelaSentija"},"attachments":[{"id":97173228,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97173228/thumbnails/1.jpg","file_name":"85792.pdf","download_url":"https://www.academia.edu/attachments/97173228/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&st=MTczMjg0MjI2Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Vulvar_Pagets_disease_a_case_report.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97173228/85792-libre.pdf?1673504722=\u0026response-content-disposition=attachment%3B+filename%3DVulvar_Pagets_disease_a_case_report.pdf\u0026Expires=1732845863\u0026Signature=KGFUzAoTpzX0ICInJUzDJTYqvrvJe4RLTwv7xZoFfTxSjeVjUfchfCDwcL~JMWRaTsJ2bnhFtyCZKAXMPS2GP0Hf1Yz6NT3zRuYHegRJ46714HerlFLpvusEo5JvH2fc7TKyXauq0~uN5YRbmvkRfQoP6ueXpC4nb5qjJ~nNKyiqEroEKSXrFVf05moJoSQciCE5bO09ZICenWjVYV8orN0petuHALZeEw0TeLChYzxzhocCNF-9I1SUYwdKafxklgRH3AXMFdHNppWMwI9sQus~JOhXT9iuW3x7aedhdtHLipaw-szR5SjgReAS7EF0TLB8A14~G1c0Cpno8pXlyA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":165,"name":"Pathology","url":"https://www.academia.edu/Documents/in/Pathology"},{"id":767,"name":"Anthropology","url":"https://www.academia.edu/Documents/in/Anthropology"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":162159,"name":"Differential Diagnosis","url":"https://www.academia.edu/Documents/in/Differential_Diagnosis"},{"id":162554,"name":"Keratin","url":"https://www.academia.edu/Documents/in/Keratin"},{"id":3916351,"name":" Vaginal smears","url":"https://www.academia.edu/Documents/in/Vaginal_smears"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94819820"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94819820/Alcohol_sclerosing_ovarian_cystic_lesions_20_years_experience"><img alt="Research paper thumbnail of Alcohol sclerosing ovarian cystic lesions, 20 years experience" class="work-thumbnail" src="https://attachments.academia-assets.com/97173241/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94819820/Alcohol_sclerosing_ovarian_cystic_lesions_20_years_experience">Alcohol sclerosing ovarian cystic lesions, 20 years experience</a></div><div class="wp-workCard_item"><span>Collegium antropologicum</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The purpose of the study is to present technique of punction and conservative treatment of cystic...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The purpose of the study is to present technique of punction and conservative treatment of cystic ovarian lesions. The following criteria were included: 1) Cyst should be unilocular, sonolucent, with a smooth inner wall of capsule, without septa and without neovasculariation on transvaginal color and power Doppler. 2) Serum CA-125 levels must be lower than 35 U/mL. The capsule of the cyst was punctured with a 18 gauge needle under the control of 5 MHz transvaginal probe. Cyst fluid was sent for cytologic examination. After complete emptying of the cyst, we injected sterile 95% ethanol in the 50-75% of the evacuated liquor amount. The alcohol remain in the cyst from 5 to 20 minutes and was then aspirated completely. We punctured cysts in 366 patients aged from 18 to 65 years, volume of cyst being between 40 and 300 mL. Patients were monitored for 24 hours and follow-up examinations were 3, 6 and 12 months after the procedure. Three cysts were ruptured (0.8%) and alcohol split in the ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c6ef1a846af444e49a3a0b58b882c189" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97173241,"asset_id":94819820,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97173241/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&st=MTczMjg0MjI2Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94819820"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94819820"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94819820; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94819820]").text(description); $(".js-view-count[data-work-id=94819820]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94819820; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94819820']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94819820, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c6ef1a846af444e49a3a0b58b882c189" } } $('.js-work-strip[data-work-id=94819820]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94819820,"title":"Alcohol sclerosing ovarian cystic lesions, 20 years experience","translated_title":"","metadata":{"abstract":"The purpose of the study is to present technique of punction and conservative treatment of cystic ovarian lesions. The following criteria were included: 1) Cyst should be unilocular, sonolucent, with a smooth inner wall of capsule, without septa and without neovasculariation on transvaginal color and power Doppler. 2) Serum CA-125 levels must be lower than 35 U/mL. The capsule of the cyst was punctured with a 18 gauge needle under the control of 5 MHz transvaginal probe. Cyst fluid was sent for cytologic examination. After complete emptying of the cyst, we injected sterile 95% ethanol in the 50-75% of the evacuated liquor amount. The alcohol remain in the cyst from 5 to 20 minutes and was then aspirated completely. We punctured cysts in 366 patients aged from 18 to 65 years, volume of cyst being between 40 and 300 mL. Patients were monitored for 24 hours and follow-up examinations were 3, 6 and 12 months after the procedure. 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We punctured cysts in 366 patients aged from 18 to 65 years, volume of cyst being between 40 and 300 mL. Patients were monitored for 24 hours and follow-up examinations were 3, 6 and 12 months after the procedure. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94819819"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94819819/Estimating_clinical_outcome_of_HPV_induced_cervical_lesions_by_combination_of_capsid_protein_L1_and_p16INK4a_protein_detection"><img alt="Research paper thumbnail of Estimating clinical outcome of HPV induced cervical lesions by combination of capsid protein L1 and p16INK4a protein detection" class="work-thumbnail" src="https://attachments.academia-assets.com/97173186/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94819819/Estimating_clinical_outcome_of_HPV_induced_cervical_lesions_by_combination_of_capsid_protein_L1_and_p16INK4a_protein_detection">Estimating clinical outcome of HPV induced cervical lesions by combination of capsid protein L1 and p16INK4a protein detection</a></div><div class="wp-workCard_item"><span>Collegium antropologicum</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to investigate whether is possible to predict clinical outcome of cervi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to investigate whether is possible to predict clinical outcome of cervical lesion by immunoassaying performed on cervical smears. During the two year study period the cervical smears of 81 patients were collected. All patients were tested for human papillomavirus (HPV) infections using Amplycor HPV test. Sixty-six of them were tested as positive for high risk types (hrHPV) and squamous intraepithelial lesion, and in those patients repeated cervical smears were taken every six months. The rest were hrHPV negative patients with normal smears which were used as a negative control in immunoassays with HPV L1 and p16INK4a antibodies. The results of p16INK4a staining in 66 hrHPV positive patients showed impairment of the cervical lesion in 22 (33.3%) and unchanged cytological finding in 21 (31.9%) p16INK4a positive patients, respectively, while improving of cytological finding was seen only in three (4.5%) p16LNK4a positive patients. On the contrary, impairment o...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="62c547a96fb883feda66e424412d2e97" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97173186,"asset_id":94819819,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97173186/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&st=MTczMjg0MjI2Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94819819"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94819819"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94819819; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94819819]").text(description); $(".js-view-count[data-work-id=94819819]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94819819; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94819819']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94819819, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "62c547a96fb883feda66e424412d2e97" } } $('.js-work-strip[data-work-id=94819819]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94819819,"title":"Estimating clinical outcome of HPV induced cervical lesions by combination of capsid protein L1 and p16INK4a protein detection","translated_title":"","metadata":{"abstract":"The aim of this study was to investigate whether is possible to predict clinical outcome of cervical lesion by immunoassaying performed on cervical smears. During the two year study period the cervical smears of 81 patients were collected. All patients were tested for human papillomavirus (HPV) infections using Amplycor HPV test. Sixty-six of them were tested as positive for high risk types (hrHPV) and squamous intraepithelial lesion, and in those patients repeated cervical smears were taken every six months. The rest were hrHPV negative patients with normal smears which were used as a negative control in immunoassays with HPV L1 and p16INK4a antibodies. The results of p16INK4a staining in 66 hrHPV positive patients showed impairment of the cervical lesion in 22 (33.3%) and unchanged cytological finding in 21 (31.9%) p16INK4a positive patients, respectively, while improving of cytological finding was seen only in three (4.5%) p16LNK4a positive patients. On the contrary, impairment o...","ai_title_tag":"Predicting Clinical Outcomes of HPV Cervical Lesions via L1 and p16","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Collegium antropologicum"},"translated_abstract":"The aim of this study was to investigate whether is possible to predict clinical outcome of cervical lesion by immunoassaying performed on cervical smears. During the two year study period the cervical smears of 81 patients were collected. All patients were tested for human papillomavirus (HPV) infections using Amplycor HPV test. Sixty-six of them were tested as positive for high risk types (hrHPV) and squamous intraepithelial lesion, and in those patients repeated cervical smears were taken every six months. The rest were hrHPV negative patients with normal smears which were used as a negative control in immunoassays with HPV L1 and p16INK4a antibodies. The results of p16INK4a staining in 66 hrHPV positive patients showed impairment of the cervical lesion in 22 (33.3%) and unchanged cytological finding in 21 (31.9%) p16INK4a positive patients, respectively, while improving of cytological finding was seen only in three (4.5%) p16LNK4a positive patients. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94819802"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94819802/Cytogenetic_and_Morphometric_Analysis_of_Placental_Cells_in_Prenatal_Diagnostic"><img alt="Research paper thumbnail of Cytogenetic and Morphometric Analysis of Placental Cells in Prenatal Diagnostic" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94819802/Cytogenetic_and_Morphometric_Analysis_of_Placental_Cells_in_Prenatal_Diagnostic">Cytogenetic and Morphometric Analysis of Placental Cells in Prenatal Diagnostic</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: In prenatal diagnostic, placental chorionic villi biopsy (chorionic villi sampling – ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: In prenatal diagnostic, placental chorionic villi biopsy (chorionic villi sampling – CVS) is used as an invasive method for cytogenetic analysis of fetal chromosomal abnormalities. The success of cytogenetic analysis depends on the amount of villi obtained by biopsy, cultivation process, and the number of metaphases suitable for cytogenetic analysis and reliable experience of the analyzer. The procedure carries a risk of miscarriage, bleeding and other complications. Despite the high sensitivity and specificity of detection of chromosomal aberrations after chorionic villus biopsy, it is not possible in all cases to implement a reliable cytogenetic analysis, and there is a need to introduce additional methods for assessment of fetal aneuploidy. Several analyses of morphometric features of euploid and aneuploid chorionic villi have been performed in experimental models on histological samples. Due to the high incidence of chromosomal aberrations and the availability of sam...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94819802"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94819802"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94819802; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94819802]").text(description); $(".js-view-count[data-work-id=94819802]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94819802; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94819802']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94819802, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=94819802]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94819802,"title":"Cytogenetic and Morphometric Analysis of Placental Cells in Prenatal Diagnostic","translated_title":"","metadata":{"abstract":"Background: In prenatal diagnostic, placental chorionic villi biopsy (chorionic villi sampling – CVS) is used as an invasive method for cytogenetic analysis of fetal chromosomal abnormalities. The success of cytogenetic analysis depends on the amount of villi obtained by biopsy, cultivation process, and the number of metaphases suitable for cytogenetic analysis and reliable experience of the analyzer. The procedure carries a risk of miscarriage, bleeding and other complications. Despite the high sensitivity and specificity of detection of chromosomal aberrations after chorionic villus biopsy, it is not possible in all cases to implement a reliable cytogenetic analysis, and there is a need to introduce additional methods for assessment of fetal aneuploidy. Several analyses of morphometric features of euploid and aneuploid chorionic villi have been performed in experimental models on histological samples. Due to the high incidence of chromosomal aberrations and the availability of sam...","publication_date":{"day":null,"month":null,"year":2012,"errors":{}}},"translated_abstract":"Background: In prenatal diagnostic, placental chorionic villi biopsy (chorionic villi sampling – CVS) is used as an invasive method for cytogenetic analysis of fetal chromosomal abnormalities. The success of cytogenetic analysis depends on the amount of villi obtained by biopsy, cultivation process, and the number of metaphases suitable for cytogenetic analysis and reliable experience of the analyzer. The procedure carries a risk of miscarriage, bleeding and other complications. Despite the high sensitivity and specificity of detection of chromosomal aberrations after chorionic villus biopsy, it is not possible in all cases to implement a reliable cytogenetic analysis, and there is a need to introduce additional methods for assessment of fetal aneuploidy. Several analyses of morphometric features of euploid and aneuploid chorionic villi have been performed in experimental models on histological samples. Due to the high incidence of chromosomal aberrations and the availability of sam...","internal_url":"https://www.academia.edu/94819802/Cytogenetic_and_Morphometric_Analysis_of_Placental_Cells_in_Prenatal_Diagnostic","translated_internal_url":"","created_at":"2023-01-11T22:08:23.365-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33146506,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Cytogenetic_and_Morphometric_Analysis_of_Placental_Cells_in_Prenatal_Diagnostic","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33146506,"first_name":"Karmela","middle_initials":null,"last_name":"Sentija","page_name":"KarmelaSentija","domain_name":"independent","created_at":"2015-07-17T14:09:02.472-07:00","display_name":"Karmela Sentija","url":"https://independent.academia.edu/KarmelaSentija"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy"},{"id":138959,"name":"Aneuploidy","url":"https://www.academia.edu/Documents/in/Aneuploidy"},{"id":1217276,"name":"Miscarriage","url":"https://www.academia.edu/Documents/in/Miscarriage"},{"id":3544618,"name":"Chorionic villus sampling","url":"https://www.academia.edu/Documents/in/Chorionic_villus_sampling"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69205566"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/69205566/_Primary_ovarian_malignant_mixed_mesodermal_tumor_MMMT_as_a_second_primary_tumor_in_a_patient_with_invasive_breast_carcinoma_case_report_"><img alt="Research paper thumbnail of [Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/69205566/_Primary_ovarian_malignant_mixed_mesodermal_tumor_MMMT_as_a_second_primary_tumor_in_a_patient_with_invasive_breast_carcinoma_case_report_">[Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of an epithelial (carcinoma) and a stromal (sarcoma) component. MMMT accounts for less than 2% of ovarian cancers and has a very poor prognosis. We present a case and difficulties of diagnosing an ovarian MMMT in a postmenopausal woman with a history of invasive breast carcinoma treated postoperatively with radiotherapy and tamoxifen. A 52-year-old patient presented with unilateral ovarian tumor and moderately elevated CA125 (107 U/mL) and underwent laparotomy. Fine needle aspiration of the ovary and ascites for cytologic analysis, and tumor biopsy for histopathology were performed intraoperatively. Intraoperative cytologic sample showed necrotic background with rare single malignant cells with pale, abundant cytoplasm and conspicuous nucleoli suggesting clear cell carcinoma. Ascites sample showed inflammatory and reactive background with suspected papillary formations mimicking adenocarcin...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69205566"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69205566"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69205566; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69205566]").text(description); $(".js-view-count[data-work-id=69205566]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69205566; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='69205566']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 69205566, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=69205566]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":69205566,"title":"[Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]","translated_title":"","metadata":{"abstract":"Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of an epithelial (carcinoma) and a stromal (sarcoma) component. MMMT accounts for less than 2% of ovarian cancers and has a very poor prognosis. We present a case and difficulties of diagnosing an ovarian MMMT in a postmenopausal woman with a history of invasive breast carcinoma treated postoperatively with radiotherapy and tamoxifen. A 52-year-old patient presented with unilateral ovarian tumor and moderately elevated CA125 (107 U/mL) and underwent laparotomy. Fine needle aspiration of the ovary and ascites for cytologic analysis, and tumor biopsy for histopathology were performed intraoperatively. Intraoperative cytologic sample showed necrotic background with rare single malignant cells with pale, abundant cytoplasm and conspicuous nucleoli suggesting clear cell carcinoma. Ascites sample showed inflammatory and reactive background with suspected papillary formations mimicking adenocarcin...","publisher":"Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti","publication_date":{"day":null,"month":null,"year":2011,"errors":{}}},"translated_abstract":"Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of an epithelial (carcinoma) and a stromal (sarcoma) component. MMMT accounts for less than 2% of ovarian cancers and has a very poor prognosis. We present a case and difficulties of diagnosing an ovarian MMMT in a postmenopausal woman with a history of invasive breast carcinoma treated postoperatively with radiotherapy and tamoxifen. A 52-year-old patient presented with unilateral ovarian tumor and moderately elevated CA125 (107 U/mL) and underwent laparotomy. Fine needle aspiration of the ovary and ascites for cytologic analysis, and tumor biopsy for histopathology were performed intraoperatively. Intraoperative cytologic sample showed necrotic background with rare single malignant cells with pale, abundant cytoplasm and conspicuous nucleoli suggesting clear cell carcinoma. Ascites sample showed inflammatory and reactive background with suspected papillary formations mimicking adenocarcin...","internal_url":"https://www.academia.edu/69205566/_Primary_ovarian_malignant_mixed_mesodermal_tumor_MMMT_as_a_second_primary_tumor_in_a_patient_with_invasive_breast_carcinoma_case_report_","translated_internal_url":"","created_at":"2022-01-22T16:55:18.791-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33146506,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_Primary_ovarian_malignant_mixed_mesodermal_tumor_MMMT_as_a_second_primary_tumor_in_a_patient_with_invasive_breast_carcinoma_case_report_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33146506,"first_name":"Karmela","middle_initials":null,"last_name":"Sentija","page_name":"KarmelaSentija","domain_name":"independent","created_at":"2015-07-17T14:09:02.472-07:00","display_name":"Karmela Sentija","url":"https://independent.academia.edu/KarmelaSentija"},"attachments":[],"research_interests":[{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3793278,"name":"Colonic Neoplasms","url":"https://www.academia.edu/Documents/in/Colonic_Neoplasms"},{"id":3881525,"name":"Ovarian Neoplasms","url":"https://www.academia.edu/Documents/in/Ovarian_Neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="62819456"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/62819456/_Clear_cell_carcinoma_of_the_endometrium_confined_to_atrophic_endometrial_polyp_case_report_"><img alt="Research paper thumbnail of [Clear cell carcinoma of the endometrium confined to atrophic endometrial polyp--case report]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/62819456/_Clear_cell_carcinoma_of_the_endometrium_confined_to_atrophic_endometrial_polyp_case_report_">[Clear cell carcinoma of the endometrium confined to atrophic endometrial polyp--case report]</a></div><div class="wp-workCard_item"><span>Acta Medica Croatica C̆asopis Hravatske Akademije Medicinskih Znanosti</span><span>, Sep 1, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Clear cell carcinoma is a rare form of endometrial carcinoma inline type II estrogen-independent....</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Clear cell carcinoma is a rare form of endometrial carcinoma inline type II estrogen-independent. It accounts for only 1% to 5.5% of all endometrial carcinomas. It is usually detected in postmenopausal women, who are older than those with endometrioid carcinoma. Clear cell carcinoma may exhibit solid, papillary, tubular and cystic patterns. The malignant cells are characterized by a moderate amount of clear or foamy cytoplasm; however, its recognition as a clear cell type of cancer cytologically is not often possible. The tumor is usually poorly differentiated, tends to be high grade, with deep myometrial invasion, lymphovascular space invasion, and metastasis in pelvic lymph node. That is why this tumor has a poor prognosis, as in our case of a 72-year-old woman with symptoms of deficient uterine bleeding. In a period of two months, two suction endometrial curettages were performed. The material obtained by endometrial curettage for histopathologic verification was very scanty. The assessment described an inactive endometrium with degenerative epithelial cells in scanty necrotic background. Direct endometrial samples with uterobrush yielded a finding of atypical epithelial cells of open etiology with dense chromatin and prominent nucleoli, also with foam cell histiocytes and old blood in the background. Cytologic diagnosis of intraepithelial lesion, possible adenocarcinoma was made. Ultrasonography of the uterus was suspect of neoplasm. After surgery, the pathologic diagnosis of endometrial clear cell carcinoma was made. It was a rare case of aggressive type of endometrial carcinoma confined to an atrophic endometrial polyp. In conclusion, we might say that direct endometrial sample can provide accurate diagnosis of endometrial tumor, especially when the endometrial tumor is a small one, thus saving time for diagnostic testing. This is based on the potential of cytology to make malignant diagnosis possible even with a few tumor cells on the slide.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="62819456"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="62819456"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 62819456; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=62819456]").text(description); $(".js-view-count[data-work-id=62819456]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 62819456; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='62819456']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 62819456, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=62819456]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":62819456,"title":"[Clear cell carcinoma of the endometrium confined to atrophic endometrial polyp--case report]","translated_title":"","metadata":{"abstract":"Clear cell carcinoma is a rare form of endometrial carcinoma inline type II estrogen-independent. It accounts for only 1% to 5.5% of all endometrial carcinomas. It is usually detected in postmenopausal women, who are older than those with endometrioid carcinoma. Clear cell carcinoma may exhibit solid, papillary, tubular and cystic patterns. The malignant cells are characterized by a moderate amount of clear or foamy cytoplasm; however, its recognition as a clear cell type of cancer cytologically is not often possible. The tumor is usually poorly differentiated, tends to be high grade, with deep myometrial invasion, lymphovascular space invasion, and metastasis in pelvic lymph node. That is why this tumor has a poor prognosis, as in our case of a 72-year-old woman with symptoms of deficient uterine bleeding. In a period of two months, two suction endometrial curettages were performed. The material obtained by endometrial curettage for histopathologic verification was very scanty. The assessment described an inactive endometrium with degenerative epithelial cells in scanty necrotic background. Direct endometrial samples with uterobrush yielded a finding of atypical epithelial cells of open etiology with dense chromatin and prominent nucleoli, also with foam cell histiocytes and old blood in the background. Cytologic diagnosis of intraepithelial lesion, possible adenocarcinoma was made. Ultrasonography of the uterus was suspect of neoplasm. After surgery, the pathologic diagnosis of endometrial clear cell carcinoma was made. It was a rare case of aggressive type of endometrial carcinoma confined to an atrophic endometrial polyp. In conclusion, we might say that direct endometrial sample can provide accurate diagnosis of endometrial tumor, especially when the endometrial tumor is a small one, thus saving time for diagnostic testing. This is based on the potential of cytology to make malignant diagnosis possible even with a few tumor cells on the slide.","publication_date":{"day":1,"month":9,"year":2011,"errors":{}},"publication_name":"Acta Medica Croatica C̆asopis Hravatske Akademije Medicinskih Znanosti"},"translated_abstract":"Clear cell carcinoma is a rare form of endometrial carcinoma inline type II estrogen-independent. It accounts for only 1% to 5.5% of all endometrial carcinomas. It is usually detected in postmenopausal women, who are older than those with endometrioid carcinoma. Clear cell carcinoma may exhibit solid, papillary, tubular and cystic patterns. The malignant cells are characterized by a moderate amount of clear or foamy cytoplasm; however, its recognition as a clear cell type of cancer cytologically is not often possible. The tumor is usually poorly differentiated, tends to be high grade, with deep myometrial invasion, lymphovascular space invasion, and metastasis in pelvic lymph node. That is why this tumor has a poor prognosis, as in our case of a 72-year-old woman with symptoms of deficient uterine bleeding. In a period of two months, two suction endometrial curettages were performed. The material obtained by endometrial curettage for histopathologic verification was very scanty. The assessment described an inactive endometrium with degenerative epithelial cells in scanty necrotic background. Direct endometrial samples with uterobrush yielded a finding of atypical epithelial cells of open etiology with dense chromatin and prominent nucleoli, also with foam cell histiocytes and old blood in the background. Cytologic diagnosis of intraepithelial lesion, possible adenocarcinoma was made. Ultrasonography of the uterus was suspect of neoplasm. After surgery, the pathologic diagnosis of endometrial clear cell carcinoma was made. It was a rare case of aggressive type of endometrial carcinoma confined to an atrophic endometrial polyp. In conclusion, we might say that direct endometrial sample can provide accurate diagnosis of endometrial tumor, especially when the endometrial tumor is a small one, thus saving time for diagnostic testing. This is based on the potential of cytology to make malignant diagnosis possible even with a few tumor cells on the slide.","internal_url":"https://www.academia.edu/62819456/_Clear_cell_carcinoma_of_the_endometrium_confined_to_atrophic_endometrial_polyp_case_report_","translated_internal_url":"","created_at":"2021-12-01T01:12:17.847-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33146506,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_Clear_cell_carcinoma_of_the_endometrium_confined_to_atrophic_endometrial_polyp_case_report_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33146506,"first_name":"Karmela","middle_initials":null,"last_name":"Sentija","page_name":"KarmelaSentija","domain_name":"independent","created_at":"2015-07-17T14:09:02.472-07:00","display_name":"Karmela Sentija","url":"https://independent.academia.edu/KarmelaSentija"},"attachments":[],"research_interests":[{"id":110562,"name":"Polyps","url":"https://www.academia.edu/Documents/in/Polyps"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":1246876,"name":"Endometrium","url":"https://www.academia.edu/Documents/in/Endometrium"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":14642691,"url":"http://www.ncbi.nlm.nih.gov/pubmed/23126043"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="62819455"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/62819455/Pra%C4%87enje_kromosomskih_aberacija_u_medicinskog_osoblja_profesionalno_izlo%C5%BEenog_djelovanju_rendgenskih_zrka"><img alt="Research paper thumbnail of Praćenje kromosomskih aberacija u medicinskog osoblja profesionalno izloženog djelovanju rendgenskih zrka" class="work-thumbnail" src="https://attachments.academia-assets.com/75465323/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/62819455/Pra%C4%87enje_kromosomskih_aberacija_u_medicinskog_osoblja_profesionalno_izlo%C5%BEenog_djelovanju_rendgenskih_zrka">Praćenje kromosomskih aberacija u medicinskog osoblja profesionalno izloženog djelovanju rendgenskih zrka</a></div><div class="wp-workCard_item"><span>Arhiv Za Higijenu Rada I Toksikologiju</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="63df8227a5a14fc0d2a36c674994ff3c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":75465323,"asset_id":62819455,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/75465323/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="62819455"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="62819455"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 62819455; 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The study comprised 100 subjects, all medical staff occupationally exposed to X-rays, who were reexamined for unstable chromosomal aberrations after 3 months (12 subjects), 6 months (31 subjects), 9 months (13 subjects), 12 months (21 subjects), over 24 months (14 subjects), and over 36 months (9 subjects) controls were 60 subjects who were not exposed to ionizing radiation or chemical mutagens at their workplaces. The results did not show timedependent recovery from chromosomal aberrations in all cases.","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Arhiv Za Higijenu Rada I Toksikologiju","grobid_abstract_attachment_id":75465323},"translated_abstract":null,"internal_url":"https://www.academia.edu/62819455/Pra%C4%87enje_kromosomskih_aberacija_u_medicinskog_osoblja_profesionalno_izlo%C5%BEenog_djelovanju_rendgenskih_zrka","translated_internal_url":"","created_at":"2021-12-01T01:12:17.675-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33146506,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":75465323,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75465323/thumbnails/1.jpg","file_name":"5578.pdf","download_url":"https://www.academia.edu/attachments/75465323/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Pracenje_kromosomskih_aberacija_u_medici.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75465323/5578-libre.pdf?1638350115=\u0026response-content-disposition=attachment%3B+filename%3DPracenje_kromosomskih_aberacija_u_medici.pdf\u0026Expires=1732845864\u0026Signature=G~j7dreDRZ3XVG8DPRc8V5wzk1jnWHbt6NfpSS6Prtz0b5HDzhblPf3jop89ZMK7uJH3abgmSVM0Z5j02cvsQQZfY-4YbXtY4oDelbOt8qjG99yIlnJGj8U2DPLeBhepnTjMMgYkEuvuLgxm4fq2zIIPk7KgitZzrSml4Y5BOI8oQjGZWg0qabVcquY2dS3mQ4TMFQEx6-LObXcUdAA~bLZLyq~gbb8e7jTjMbiWOEyYvWNqD4EUJPuxd1-HedWrrEwSHVjUNK8N1pNEja-2RxOW4FpvHKSfJRGVTjRZyoKMR-q7sMXr~5bcwDKPbFsDh-DfIJymRihFV0fvBFrEuA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Praćenje_kromosomskih_aberacija_u_medicinskog_osoblja_profesionalno_izloženog_djelovanju_rendgenskih_zrka","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":33146506,"first_name":"Karmela","middle_initials":null,"last_name":"Sentija","page_name":"KarmelaSentija","domain_name":"independent","created_at":"2015-07-17T14:09:02.472-07:00","display_name":"Karmela Sentija","url":"https://independent.academia.edu/KarmelaSentija"},"attachments":[{"id":75465323,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75465323/thumbnails/1.jpg","file_name":"5578.pdf","download_url":"https://www.academia.edu/attachments/75465323/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Pracenje_kromosomskih_aberacija_u_medici.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75465323/5578-libre.pdf?1638350115=\u0026response-content-disposition=attachment%3B+filename%3DPracenje_kromosomskih_aberacija_u_medici.pdf\u0026Expires=1732845864\u0026Signature=G~j7dreDRZ3XVG8DPRc8V5wzk1jnWHbt6NfpSS6Prtz0b5HDzhblPf3jop89ZMK7uJH3abgmSVM0Z5j02cvsQQZfY-4YbXtY4oDelbOt8qjG99yIlnJGj8U2DPLeBhepnTjMMgYkEuvuLgxm4fq2zIIPk7KgitZzrSml4Y5BOI8oQjGZWg0qabVcquY2dS3mQ4TMFQEx6-LObXcUdAA~bLZLyq~gbb8e7jTjMbiWOEyYvWNqD4EUJPuxd1-HedWrrEwSHVjUNK8N1pNEja-2RxOW4FpvHKSfJRGVTjRZyoKMR-q7sMXr~5bcwDKPbFsDh-DfIJymRihFV0fvBFrEuA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":75465322,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/75465322/thumbnails/1.jpg","file_name":"5578.pdf","download_url":"https://www.academia.edu/attachments/75465322/download_file","bulk_download_file_name":"Pracenje_kromosomskih_aberacija_u_medici.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/75465322/5578-libre.pdf?1638350114=\u0026response-content-disposition=attachment%3B+filename%3DPracenje_kromosomskih_aberacija_u_medici.pdf\u0026Expires=1732845864\u0026Signature=TdGKDVCkBPm-YfFyvPpxZdTTCrtAKIGwxpFjzRt~H8gHUchB~Zcel100r3zq-PkL8JpTdq5MLPqD-xms50A7HcmDAAssSepEju6i8574XTWs-OvYHJZKvWVtMkg7Io95TVpb2IWNeAN0EnDOJarrmVmUQ2EWgfKH7iEtlJYPsnqZk3Frf19V9N1Nk~7TWIGsTkBIr2LNTHXjQ1dTd0cMveLzNUZ~xgAwchjZYaG0ML6zlYypbV6F0xQrd31lySxWDU1583COPjlMSYeEWhrE6aw7iuo6fxqRfLOg9WuU0jaW1zk1pHHpsq0B8ERDJIieBD354DvNrIG4FYXtSX1qEA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":14642690,"url":"http://hrcak.srce.hr/file/5578"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="62819454"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/62819454/Chromosome_aberrations_in_peripheral_blood_lymphocytes_from_control_individuals"><img alt="Research paper thumbnail of Chromosome aberrations in peripheral blood lymphocytes from control individuals" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/62819454/Chromosome_aberrations_in_peripheral_blood_lymphocytes_from_control_individuals">Chromosome aberrations in peripheral blood lymphocytes from control individuals</a></div><div class="wp-workCard_item"><span>Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis</span><span>, Apr 30, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Bender et al., 1989. MA Bender, RJ Preston, RC Leonard, BE Pyatt and PC Gooch , Chromosomal a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Bender et al., 1989. MA Bender, RJ Preston, RC Leonard, BE Pyatt and PC Gooch , Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human populatiion sample. In: II. ... 149154. Abstract | PDF (455 K). Evan, 1979. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="62819454"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="62819454"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 62819454; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=62819454]").text(description); $(".js-view-count[data-work-id=62819454]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 62819454; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='62819454']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 62819454, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=62819454]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":62819454,"title":"Chromosome aberrations in peripheral blood lymphocytes from control individuals","translated_title":"","metadata":{"abstract":"... Bender et al., 1989. MA Bender, RJ Preston, RC Leonard, BE Pyatt and PC Gooch , Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human populatiion sample. In: II. ... 149154. Abstract | PDF (455 K). Evan, 1979. ...","publication_date":{"day":30,"month":4,"year":1995,"errors":{}},"publication_name":"Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis"},"translated_abstract":"... Bender et al., 1989. MA Bender, RJ Preston, RC Leonard, BE Pyatt and PC Gooch , Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human populatiion sample. In: II. ... 149154. Abstract | PDF (455 K). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="62819354"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/62819354/Cytogenetic_changes_in_subjects_occupationally_exposed_to_benzene"><img alt="Research paper thumbnail of Cytogenetic changes in subjects occupationally exposed to benzene" class="work-thumbnail" src="https://attachments.academia-assets.com/75465370/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/62819354/Cytogenetic_changes_in_subjects_occupationally_exposed_to_benzene">Cytogenetic changes in subjects occupationally exposed to benzene</a></div><div class="wp-workCard_item"><span>Chemosphere</span><span>, 2000</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bbc2d120ceea6a2c0cad05db0140e264" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":75465370,"asset_id":62819354,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/75465370/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="62819354"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="62819354"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 62819354; 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The genotoxic eects of benzene were assessed in peripheral blood lymphocytes of 36 workers employed in the shoe industry for a period extending from seven months to over 30 years. Chromosomal aberrations and sister chromatide exchanges were used as indicators of genotoxic eects. The incidence of dicentric chromosomes in the exposed group was signi®cantly higher than in the control group (P \u003c 0.05). No signi®cant increase was detected between the working period in the exposed group and chromosomal aberrations. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14023750"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14023750/_Primary_ovarian_malignant_mixed_mesodermal_tumor_MMMT_as_a_second_primary_tumor_in_a_patient_with_invasive_breast_carcinoma_case_report_"><img alt="Research paper thumbnail of [Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14023750/_Primary_ovarian_malignant_mixed_mesodermal_tumor_MMMT_as_a_second_primary_tumor_in_a_patient_with_invasive_breast_carcinoma_case_report_">[Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/KarmelaSentija">Karmela Sentija</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://mef.academia.edu/VlastimirKukura">Vlastimir Kukura</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://mef.academia.edu/SlavkoGasparov">Slavko Gasparov</a></span></div><div class="wp-workCard_item"><span>Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of an epithelial (carcinoma) and a stromal (sarcoma) component. MMMT accounts for less than 2% of ovarian cancers and has a very poor prognosis. We present a case and difficulties of diagnosing an ovarian MMMT in a postmenopausal woman with a history of invasive breast carcinoma treated postoperatively with radiotherapy and tamoxifen. A 52-year-old patient presented with unilateral ovarian tumor and moderately elevated CA125 (107 U/mL) and underwent laparotomy. Fine needle aspiration of the ovary and ascites for cytologic analysis, and tumor biopsy for histopathology were performed intraoperatively. Intraoperative cytologic sample showed necrotic background with rare single malignant cells with pale, abundant cytoplasm and conspicuous nucleoli suggesting clear cell carcinoma. Ascites sample showed inflammatory and reactive background with suspected papillary formations mimicking adenocarcin...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14023750"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14023750"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14023750; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14023750]").text(description); $(".js-view-count[data-work-id=14023750]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14023750; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14023750']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 14023750, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14023750]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14023750,"title":"[Primary ovarian malignant mixed mesodermal tumor (MMMT) as a second primary tumor in a patient with invasive breast carcinoma--case report]","translated_title":"","metadata":{"abstract":"Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of an epithelial (carcinoma) and a stromal (sarcoma) component. MMMT accounts for less than 2% of ovarian cancers and has a very poor prognosis. We present a case and difficulties of diagnosing an ovarian MMMT in a postmenopausal woman with a history of invasive breast carcinoma treated postoperatively with radiotherapy and tamoxifen. A 52-year-old patient presented with unilateral ovarian tumor and moderately elevated CA125 (107 U/mL) and underwent laparotomy. Fine needle aspiration of the ovary and ascites for cytologic analysis, and tumor biopsy for histopathology were performed intraoperatively. Intraoperative cytologic sample showed necrotic background with rare single malignant cells with pale, abundant cytoplasm and conspicuous nucleoli suggesting clear cell carcinoma. Ascites sample showed inflammatory and reactive background with suspected papillary formations mimicking adenocarcin...","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti"},"translated_abstract":"Malignant mixed mesodermal tumor (MMMT) of the ovary is a rare aggressive tumor that consists of an epithelial (carcinoma) and a stromal (sarcoma) component. MMMT accounts for less than 2% of ovarian cancers and has a very poor prognosis. We present a case and difficulties of diagnosing an ovarian MMMT in a postmenopausal woman with a history of invasive breast carcinoma treated postoperatively with radiotherapy and tamoxifen. A 52-year-old patient presented with unilateral ovarian tumor and moderately elevated CA125 (107 U/mL) and underwent laparotomy. Fine needle aspiration of the ovary and ascites for cytologic analysis, and tumor biopsy for histopathology were performed intraoperatively. Intraoperative cytologic sample showed necrotic background with rare single malignant cells with pale, abundant cytoplasm and conspicuous nucleoli suggesting clear cell carcinoma. 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That increase may serve as a marker for dysplastic and neoplastic cells of the uterine cervical epithelium. The aim of this study is to assess the p16INK4a protein expression in different stages of cytological abnormality in correlation with the proven high oncogenic risk human papillomavirus infection in order to demonstrate its value as the diagnostic marker. The study included cervical smear samples of 371 patient in whom the viral typization was done. In 171 patient, during their regular gynaecological examination, along with conventional Pap smear sampling an additional smear was taken. Two hundred cervix brush (Rovers Medical DevicesOss, the Netherlands) samples were obtained and analyzed by the LBC method and the ThinPrep2000 machine. All samples were analyzed cytologically, classified according to the Bethesda system, and immunostained wi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="28540d75730a2a1af71ac246d7f74877" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44695056,"asset_id":14023749,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44695056/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14023749"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14023749"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14023749; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14023749]").text(description); $(".js-view-count[data-work-id=14023749]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14023749; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14023749']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 14023749, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "28540d75730a2a1af71ac246d7f74877" } } $('.js-work-strip[data-work-id=14023749]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14023749,"title":"[P16NIK4a expression in premalignant cervical lesions]","translated_title":"","metadata":{"abstract":"Increased expression of viral E6 and E7 oncoproteins within the host cells results in an increase in cellular protein p16INK4a expression. That increase may serve as a marker for dysplastic and neoplastic cells of the uterine cervical epithelium. The aim of this study is to assess the p16INK4a protein expression in different stages of cytological abnormality in correlation with the proven high oncogenic risk human papillomavirus infection in order to demonstrate its value as the diagnostic marker. The study included cervical smear samples of 371 patient in whom the viral typization was done. In 171 patient, during their regular gynaecological examination, along with conventional Pap smear sampling an additional smear was taken. Two hundred cervix brush (Rovers Medical DevicesOss, the Netherlands) samples were obtained and analyzed by the LBC method and the ThinPrep2000 machine. All samples were analyzed cytologically, classified according to the Bethesda system, and immunostained wi...","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti"},"translated_abstract":"Increased expression of viral E6 and E7 oncoproteins within the host cells results in an increase in cellular protein p16INK4a expression. That increase may serve as a marker for dysplastic and neoplastic cells of the uterine cervical epithelium. The aim of this study is to assess the p16INK4a protein expression in different stages of cytological abnormality in correlation with the proven high oncogenic risk human papillomavirus infection in order to demonstrate its value as the diagnostic marker. The study included cervical smear samples of 371 patient in whom the viral typization was done. 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Conditions","url":"https://www.academia.edu/Documents/in/Precancerous_Conditions"},{"id":1199592,"name":"Cervical Intraepithelial Neoplasia","url":"https://www.academia.edu/Documents/in/Cervical_Intraepithelial_Neoplasia"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14023748"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14023748/Vulvar_Pagets_disease_a_case_report"><img alt="Research paper thumbnail of Vulvar Paget's disease--a case report" class="work-thumbnail" src="https://attachments.academia-assets.com/44695026/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14023748/Vulvar_Pagets_disease_a_case_report">Vulvar Paget's disease--a case report</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/KarmelaSentija">Karmela Sentija</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://mef.academia.edu/VlastimirKukura">Vlastimir Kukura</a></span></div><div class="wp-workCard_item"><span>Collegium antropologicum</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. It accounts for less t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. It accounts for less than 1% of all vulvar neoplasia and usually appears in postmenopausal women. Histologically it is analogous to Paget&#39;s disease of the breast. The most common clinical symptom is pruritus. The lesion appears as an erythematous or as an eczematous lesion with islands of hyperkeratosis. Occasionally, single anaplastic Paget&#39;s cells can be found on the vulvar smears which make cytological diagnosis of the disease possible. However, the disease can be diagnosed only by biopsy. We present a case of 49-year old woman with vulvar symptoms of pruritus, who had liver and kidney transplantation two years ago. During the standard gynecological examination the vulvar smear was taken for cytological evaluation. The smear was scanty, with inflammatory background, overloaded with squamae. There were two types of cells: dysplastic squamous cells from lower layer of the epithelium and the single, a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="590c258c364281e8a5a82000997bd2c5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44695026,"asset_id":14023748,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44695026/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14023748"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14023748"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14023748; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14023748]").text(description); $(".js-view-count[data-work-id=14023748]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14023748; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14023748']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 14023748, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "590c258c364281e8a5a82000997bd2c5" } } $('.js-work-strip[data-work-id=14023748]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14023748,"title":"Vulvar Paget's disease--a case report","translated_title":"","metadata":{"abstract":"Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. It accounts for less than 1% of all vulvar neoplasia and usually appears in postmenopausal women. Histologically it is analogous to Paget\u0026#39;s disease of the breast. The most common clinical symptom is pruritus. The lesion appears as an erythematous or as an eczematous lesion with islands of hyperkeratosis. Occasionally, single anaplastic Paget\u0026#39;s cells can be found on the vulvar smears which make cytological diagnosis of the disease possible. However, the disease can be diagnosed only by biopsy. We present a case of 49-year old woman with vulvar symptoms of pruritus, who had liver and kidney transplantation two years ago. During the standard gynecological examination the vulvar smear was taken for cytological evaluation. The smear was scanty, with inflammatory background, overloaded with squamae. There were two types of cells: dysplastic squamous cells from lower layer of the epithelium and the single, a...","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Collegium antropologicum"},"translated_abstract":"Vulvar Morbus Paget (MP) represents a rare intraepithelial adenocarcinoma. It accounts for less than 1% of all vulvar neoplasia and usually appears in postmenopausal women. Histologically it is analogous to Paget\u0026#39;s disease of the breast. The most common clinical symptom is pruritus. The lesion appears as an erythematous or as an eczematous lesion with islands of hyperkeratosis. Occasionally, single anaplastic Paget\u0026#39;s cells can be found on the vulvar smears which make cytological diagnosis of the disease possible. However, the disease can be diagnosed only by biopsy. We present a case of 49-year old woman with vulvar symptoms of pruritus, who had liver and kidney transplantation two years ago. During the standard gynecological examination the vulvar smear was taken for cytological evaluation. The smear was scanty, with inflammatory background, overloaded with squamae. There were two types of cells: dysplastic squamous cells from lower layer of the epithelium and the single, a...","internal_url":"https://www.academia.edu/14023748/Vulvar_Pagets_disease_a_case_report","translated_internal_url":"","created_at":"2015-07-14T02:49:14.982-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33053887,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":3101119,"work_id":14023748,"tagging_user_id":33053887,"tagged_user_id":33146506,"co_author_invite_id":784437,"email":"k***a@yahoo.com","display_order":0,"name":"Karmela Sentija","title":"Vulvar Paget's disease--a case report"},{"id":3101126,"work_id":14023748,"tagging_user_id":33053887,"tagged_user_id":null,"co_author_invite_id":784439,"email":"s***a@centrum.cz","display_order":4194304,"name":"Suzana Simon","title":"Vulvar Paget's disease--a case report"}],"downloadable_attachments":[{"id":44695026,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44695026/thumbnails/1.jpg","file_name":"Vulvar_Pagets_disease--a_case_report20160413-2631-15tyoxa.pdf","download_url":"https://www.academia.edu/attachments/44695026/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Vulvar_Pagets_disease_a_case_report.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44695026/Vulvar_Pagets_disease--a_case_report20160413-2631-15tyoxa-libre.pdf?1460552323=\u0026response-content-disposition=attachment%3B+filename%3DVulvar_Pagets_disease_a_case_report.pdf\u0026Expires=1732839806\u0026Signature=b3LQ4YELAg4EhypU8jW0Z8G2HlGmGQ5oUWvfUhGILt-Ir29V~cTiZMyKtOF1oOY2g7qMKlFJKvNiMilX6PpngXsk7Qnl8KXWO9Cs~HUjFt7FiZFCyXblhKPx2iTumyBFlRvdLCp8Tx7tCDtZWjpbcc8yXQ4P~394Dha8K5LrYEyyNxGDhKTBGPdJtBOabeSgmMSiTvsLjvlNUL3TqA8O~h-zOiSlun2t9EFu1EPljtIH7YfSn851vtj0ub9lxWyglyN-WOkrv6l-dIbMhtpweQmWx-fATPf0hG5wcEuOwDdP7NMIMKHUWlFReG-Kvt73NyB-j6Ip3T5nWKAdcGa80w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Vulvar_Pagets_disease_a_case_report","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":33053887,"first_name":"Vlastimir","middle_initials":null,"last_name":"Kukura","page_name":"VlastimirKukura","domain_name":"mef","created_at":"2015-07-14T02:44:43.319-07:00","display_name":"Vlastimir Kukura","url":"https://mef.academia.edu/VlastimirKukura"},"attachments":[{"id":44695026,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44695026/thumbnails/1.jpg","file_name":"Vulvar_Pagets_disease--a_case_report20160413-2631-15tyoxa.pdf","download_url":"https://www.academia.edu/attachments/44695026/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Vulvar_Pagets_disease_a_case_report.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44695026/Vulvar_Pagets_disease--a_case_report20160413-2631-15tyoxa-libre.pdf?1460552323=\u0026response-content-disposition=attachment%3B+filename%3DVulvar_Pagets_disease_a_case_report.pdf\u0026Expires=1732839806\u0026Signature=b3LQ4YELAg4EhypU8jW0Z8G2HlGmGQ5oUWvfUhGILt-Ir29V~cTiZMyKtOF1oOY2g7qMKlFJKvNiMilX6PpngXsk7Qnl8KXWO9Cs~HUjFt7FiZFCyXblhKPx2iTumyBFlRvdLCp8Tx7tCDtZWjpbcc8yXQ4P~394Dha8K5LrYEyyNxGDhKTBGPdJtBOabeSgmMSiTvsLjvlNUL3TqA8O~h-zOiSlun2t9EFu1EPljtIH7YfSn851vtj0ub9lxWyglyN-WOkrv6l-dIbMhtpweQmWx-fATPf0hG5wcEuOwDdP7NMIMKHUWlFReG-Kvt73NyB-j6Ip3T5nWKAdcGa80w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":767,"name":"Anthropology","url":"https://www.academia.edu/Documents/in/Anthropology"},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation"},{"id":155901,"name":"Liver Transplantation","url":"https://www.academia.edu/Documents/in/Liver_Transplantation"},{"id":162554,"name":"Keratin","url":"https://www.academia.edu/Documents/in/Keratin"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14023747"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14023747/Alcohol_sclerosing_ovarian_cystic_lesions_20_years_experience"><img alt="Research paper thumbnail of Alcohol sclerosing ovarian cystic lesions, 20 years experience" class="work-thumbnail" src="https://attachments.academia-assets.com/44695035/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14023747/Alcohol_sclerosing_ovarian_cystic_lesions_20_years_experience">Alcohol sclerosing ovarian cystic lesions, 20 years experience</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/KarmelaSentija">Karmela Sentija</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://mef.academia.edu/VlastimirKukura">Vlastimir Kukura</a></span></div><div class="wp-workCard_item"><span>Collegium antropologicum</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The purpose of the study is to present technique of punction and conservative treatment of cystic...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The purpose of the study is to present technique of punction and conservative treatment of cystic ovarian lesions. The following criteria were included: 1) Cyst should be unilocular, sonolucent, with a smooth inner wall of capsule, without septa and without neovasculariation on transvaginal color and power Doppler. 2) Serum CA-125 levels must be lower than 35 U/mL. The capsule of the cyst was punctured with a 18 gauge needle under the control of 5 MHz transvaginal probe. Cyst fluid was sent for cytologic examination. After complete emptying of the cyst, we injected sterile 95% ethanol in the 50-75% of the evacuated liquor amount. The alcohol remain in the cyst from 5 to 20 minutes and was then aspirated completely. We punctured cysts in 366 patients aged from 18 to 65 years, volume of cyst being between 40 and 300 mL. Patients were monitored for 24 hours and follow-up examinations were 3, 6 and 12 months after the procedure. Three cysts were ruptured (0.8%) and alcohol split in the ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="376d0cfb1f7c5fdd355d559acfb3987b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44695035,"asset_id":14023747,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44695035/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14023747"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14023747"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14023747; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14023747]").text(description); $(".js-view-count[data-work-id=14023747]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14023747; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14023747']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 14023747, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "376d0cfb1f7c5fdd355d559acfb3987b" } } $('.js-work-strip[data-work-id=14023747]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14023747,"title":"Alcohol sclerosing ovarian cystic lesions, 20 years experience","translated_title":"","metadata":{"abstract":"The purpose of the study is to present technique of punction and conservative treatment of cystic ovarian lesions. The following criteria were included: 1) Cyst should be unilocular, sonolucent, with a smooth inner wall of capsule, without septa and without neovasculariation on transvaginal color and power Doppler. 2) Serum CA-125 levels must be lower than 35 U/mL. The capsule of the cyst was punctured with a 18 gauge needle under the control of 5 MHz transvaginal probe. Cyst fluid was sent for cytologic examination. After complete emptying of the cyst, we injected sterile 95% ethanol in the 50-75% of the evacuated liquor amount. The alcohol remain in the cyst from 5 to 20 minutes and was then aspirated completely. We punctured cysts in 366 patients aged from 18 to 65 years, volume of cyst being between 40 and 300 mL. Patients were monitored for 24 hours and follow-up examinations were 3, 6 and 12 months after the procedure. Three cysts were ruptured (0.8%) and alcohol split in the ...","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Collegium antropologicum"},"translated_abstract":"The purpose of the study is to present technique of punction and conservative treatment of cystic ovarian lesions. The following criteria were included: 1) Cyst should be unilocular, sonolucent, with a smooth inner wall of capsule, without septa and without neovasculariation on transvaginal color and power Doppler. 2) Serum CA-125 levels must be lower than 35 U/mL. The capsule of the cyst was punctured with a 18 gauge needle under the control of 5 MHz transvaginal probe. Cyst fluid was sent for cytologic examination. After complete emptying of the cyst, we injected sterile 95% ethanol in the 50-75% of the evacuated liquor amount. The alcohol remain in the cyst from 5 to 20 minutes and was then aspirated completely. We punctured cysts in 366 patients aged from 18 to 65 years, volume of cyst being between 40 and 300 mL. Patients were monitored for 24 hours and follow-up examinations were 3, 6 and 12 months after the procedure. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14160331"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14160331/Radiation_induced_chromosomal_aberrations_and_haematological_alterations_in_hospital_workers"><img alt="Research paper thumbnail of Radiation-induced chromosomal aberrations and haematological alterations in hospital workers" class="work-thumbnail" src="https://attachments.academia-assets.com/44553144/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14160331/Radiation_induced_chromosomal_aberrations_and_haematological_alterations_in_hospital_workers">Radiation-induced chromosomal aberrations and haematological alterations in hospital workers</a></div><div class="wp-workCard_item"><span>Occupational Medicine</span><span>, 1999</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0c564c7d0c93a57804c37bfb57715d07" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44553144,"asset_id":14160331,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44553144/download_file?st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&st=MTczMjg0MjI2NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14160331"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14160331"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14160331; 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wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14023746/Estimating_clinical_outcome_of_HPV_induced_cervical_lesions_by_combination_of_capsid_protein_L1_and_p16INK4a_protein_detection">Estimating clinical outcome of HPV induced cervical lesions by combination of capsid protein L1 and p16INK4a protein detection</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/KarmelaSentija">Karmela Sentija</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://mef.academia.edu/VlastimirKukura">Vlastimir Kukura</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://unizg.academia.edu/JasminaVranes">Jasmina Vranes</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/InesBolanca">Ines Bolanča</a></span></div><div class="wp-workCard_item"><span>Collegium antropologicum</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to investigate whether is possible to predict clinical outcome of cervi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to investigate whether is possible to predict clinical outcome of cervical lesion by immunoassaying performed on cervical smears. During the two year study period the cervical smears of 81 patients were collected. All patients were tested for human papillomavirus (HPV) infections using Amplycor HPV test. Sixty-six of them were tested as positive for high risk types (hrHPV) and squamous intraepithelial lesion, and in those patients repeated cervical smears were taken every six months. The rest were hrHPV negative patients with normal smears which were used as a negative control in immunoassays with HPV L1 and p16INK4a antibodies. The results of p16INK4a staining in 66 hrHPV positive patients showed impairment of the cervical lesion in 22 (33.3%) and unchanged cytological finding in 21 (31.9%) p16INK4a positive patients, respectively, while improving of cytological finding was seen only in three (4.5%) p16LNK4a positive patients. 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