Search results for: neuromyelitis

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class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 2</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: neuromyelitis</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Neuromyelitis Optica area Postrema Syndrome(NMOSD-APS) in a Fifteen-year-old Girl: A Case Report</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Merilin%20Ivanova%20Ivanova">Merilin Ivanova Ivanova</a>, <a href="https://publications.waset.org/abstracts/search?q=Kalin%20Dimitrov%20Atanasov"> Kalin Dimitrov Atanasov</a>, <a href="https://publications.waset.org/abstracts/search?q=Stefan%20Petrov%20Enchev"> Stefan Petrov Enchev</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Backgroud: Neuromyelitis optica spectrum disorder, also known as Devic’s disease, is a relapsing demyelinating autoimmune inflammatory disorder of the central nervous system associated with anti-aquaporin 4 (AQP4) antibodies that can manifest with devastating secondary neurological deficits. Most commonly affected are the optic nerves and the spinal cord-clinically this is often presented with optic neuritis (loss of vision), transverse myelitis(weakness or paralysis of extremities),lack of bladder and bowel control, numbness. APS is a core clinical entity of NMOSD and adds to the clinical representation the following symptoms: intractable nausea, vomiting and hiccup, it usually occurs isolated at onset, and can lead to a significant delay in the diagnosis. The condition may have features similar to multiple sclerosis (MS) but the episodes are worse in NMO and it is treated differently. It could be relapsing or monophasic. Possible complications are visual field defects and motor impairment, with potential blindness and irreversible motor deficits. In severe cases, myogenic respiratory failure ensues. The incidence of reported cases is approximately 0.3–4.4 per 100,000. Paediatric cases of NMOSD are rare but have been reported occasionally, comprising less than 5% of the reported cases. Objective: The case serves to show the difficulty when it comes to the diagnostic processes regarding a rare autoimmune disease with non- specific symptoms, taking large interval of rimes to reveal as complete clinical manifestation of the aforementioned syndrome, as well as the necessity of multidisciplinary approach in the setting of а general paediatric department in аn emergency hospital. Methods: itpatient's history, clinical presentation, and information from the used diagnostic tools(MRI with contrast of the central nervous system) lead us to the conclusion .This was later on confirmed by the positive results from the anti-aquaporin 4 (AQP4) antibody serology test. Conclusion: APS is a common symptom of NMOSD and is considered a challenge in a differential-diagnostic plan. Gaining an increased awareness of this disease/syndrome, obtaining a detailed patient history, and performing thorough physical examinations are essential if we are to reduce and avoid misdiagnosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=neuromyelitis" title="neuromyelitis">neuromyelitis</a>, <a href="https://publications.waset.org/abstracts/search?q=devic%27s%20disease" title=" devic's disease"> devic's disease</a>, <a href="https://publications.waset.org/abstracts/search?q=hiccup" title=" hiccup"> hiccup</a>, <a href="https://publications.waset.org/abstracts/search?q=autoimmune" title=" autoimmune"> autoimmune</a>, <a href="https://publications.waset.org/abstracts/search?q=MRI" title=" MRI"> MRI</a> </p> <a href="https://publications.waset.org/abstracts/182547/neuromyelitis-optica-area-postrema-syndromenmosd-aps-in-a-fifteen-year-old-girl-a-case-report" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/182547.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">48</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Less Common Clinical Phenotypes of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease in Children: A Comprehensive Review of Misdiagnosis and Clinical Features</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ping%20Yuan">Ping Yuan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: The aim of the study is to improve the identification of less common clinical phenotypes of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) in children. Methods: We retrospectively reviewed the medical records of 236 patients diagnosed with MOGAD. The following clinical phenotypes were considered typical for MOGAD: acute disseminated encephalomyelitis (ADEM), optic neuritis (ON), transverse myelitis (TM), and neuromyelitis optica spectrum disorder (NMOSD). Less common onset phenotypes were identified and analyzed, including their clinical presentation, magnetic resonance imaging (MRI) findings, diagnosis, treatment, and prognosis. Results: Sixteen cases (6.8%) presented with cortical encephalitis, characterized by convulsions, headache, and fever as the primary symptoms. Fifteen of these cases were initially misdiagnosed. Thirteen cases (5.5%) exhibited overlapping syndromes of MOGAD and anti-N-methyl-D-aspartate receptor encephalitis (NMOS), with seizures being the most common symptom (92.3%). Of these, 11 cases (84.6%) experienced relapses. Seven cases (3.0%) presented with a cerebral leukodystrophy-like phenotype, with a recurrence rate of 50%. Three cases (1.3%) had isolated seizures without MRI findings, with focal seizures as the only symptom. Three cases (1.3%) had an aseptic meningitis phenotype, presenting with prolonged fever. Conclusion: Among the 236 children with MOGAD, 40 (16.9%) exhibited less common clinical phenotypes. These rare phenotypes are often susceptible to misdiagnosis and warrant increased clinical awareness. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=myelin%20oligodendrocyte%20glycoprotein%20antibody-associated%20disease" title="myelin oligodendrocyte glycoprotein antibody-associated disease">myelin oligodendrocyte glycoprotein antibody-associated disease</a>, <a href="https://publications.waset.org/abstracts/search?q=pediatric%20MOGAD" title=" pediatric MOGAD"> pediatric MOGAD</a>, <a href="https://publications.waset.org/abstracts/search?q=clinical%20misdiagnosis" title=" clinical misdiagnosis"> clinical misdiagnosis</a>, <a href="https://publications.waset.org/abstracts/search?q=rare%20phenotypes" title=" rare phenotypes"> rare phenotypes</a>, <a href="https://publications.waset.org/abstracts/search?q=seizures" title=" seizures"> seizures</a> </p> <a href="https://publications.waset.org/abstracts/199010/less-common-clinical-phenotypes-of-myelin-oligodendrocyte-glycoprotein-antibody-associated-disease-in-children-a-comprehensive-review-of-misdiagnosis-and-clinical-features" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/199010.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" 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Search results for: neuromyelitis