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<!DOCTYPE html> <html data-head-attrs="" lang="en"> <head> <meta charset="UTF-8"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <meta name="mobile-web-app-capable" content="yes"> <meta name="apple-mobile-web-app-status-bar-style" content="black"> <meta name="theme-color" content="#ffffff"> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/5.0.1/css/bootstrap.min.css" integrity="sha512-Ez0cGzNzHR1tYAv56860NLspgUGuQw16GiOOp/I2LuTmpSK9xDXlgJz3XN4cnpXWDmkNBKXR/VDMTCnAaEooxA==" crossorigin="anonymous" referrerpolicy="no-referrer" /> <link rel="preconnect" href="https://fonts.googleapis.com"> <link rel="preconnect" href="https://fonts.gstatic.com" crossorigin> <script type="module" crossorigin src="https://pbcdn1.podbean.com/fs1/user-site-dist/assets/index.7276e018.js"></script> <link rel="modulepreload" href="https://pbcdn1.podbean.com/fs1/user-site-dist/assets/vendor.926efe0f.js"> <link rel="stylesheet" href="https://pbcdn1.podbean.com/fs1/user-site-dist/assets/index.0a4bb8b8.css"> <link rel="manifest" href="/user-site/manifest.webmanifest" crossorigin="use-credentials"><title>Gene Therapy for Sickle Cell Disease | BREAKING THROUGH with Madeline Bell</title><link rel="icon" href="https://www.podbean.com/favicon.ico"><link rel="apple-touch-icon" href="https://www.podbean.com/favicon.ico"><meta property="og:title" content="Gene Therapy for Sickle Cell Disease | BREAKING THROUGH with Madeline Bell"><meta property="og:image" content="https://d2bwo9zemjwxh5.cloudfront.net/image-logo/2691026/Generic-Podbean-1080x1080-2x_t7wnw6_1200x628.jpg?s=d257b565b4a4efad1c49c47fb2ba0685&e=jpg"><meta property="og:type" content="article"><meta property="og:url" content="https://breakingthrough.podbean.com/e/gene-therapy-for-sickle-cell-disease/"><meta property="og:description" content="Sickle cell disease is an inherited blood disorder that often causes debilitating pain and life-threatening complications. Many patients with the disease make dozens of ER visits a year, and must receive regular blood transfusions. And though recent breakthroughs in gene therapy are giving patients with sickle cell new hope – and new options – accessing these therapies can be challenging. In this episode of Breaking Through, cell and gene therapy expert Dr. Stephan Grupp and pediatric hematologist Dr. Alexis Thompson join Madeline to talk about how gene therapy for sickle cell disease can transform patients’ lives. They also discuss what teams at Children’s Hospital of Philadelphia (CHOP) are doing to ensure that these innovative therapies reach the children who need them most. "><meta name="description" content="Sickle cell disease is an inherited blood disorder that often causes debilitating pain and life-threatening complications. Many patients with the disease make dozens of ER visits a year, and must receive regular blood transfusions. And though recent breakthroughs in gene therapy are giving patients with sickle cell new hope – and new options – accessing these therapies can be challenging. In this episode of Breaking Through, cell and gene therapy expert Dr. Stephan Grupp and pediatric hematologist Dr. Alexis Thompson join Madeline to talk about how gene therapy for sickle cell disease can transform patients’ lives. They also discuss what teams at Children’s Hospital of Philadelphia (CHOP) are doing to ensure that these innovative therapies reach the children who need them most. "><meta name="twitter:card" content="player"><meta name="twitter:site" content="@podbeancom"><meta name="twitter:url" content="https://breakingthrough.podbean.com/e/gene-therapy-for-sickle-cell-disease/"><meta name="twitter:title" content="Gene Therapy for Sickle Cell Disease | BREAKING THROUGH with Madeline Bell"><meta name="twitter:description" content="Sickle cell disease is an inherited blood disorder that often causes debilitating pain and life-threatening complications. Many patients with the disease make dozens of ER visits a year, and must receive regular blood transfusions. And though recent breakthroughs in gene therapy are giving patients with sickle cell new hope – and new options – accessing these therapies can be challenging. In this episode of Breaking Through, cell and gene therapy expert Dr. Stephan Grupp and pediatric hematologist Dr. Alexis Thompson join Madeline to talk about how gene therapy for sickle cell disease can transform patients’ lives. They also discuss what teams at Children’s Hospital of Philadelphia (CHOP) are doing to ensure that these innovative therapies reach the children who need them most. 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Many patients with the disease make dozens of ER visits a year, and must receive regular blood transfusions. And though recent breakthroughs in gene therapy are giving patients with sickle cell new hope – and new options – accessing these therapies can be challenging. In this episode of Breaking Through, cell and gene therapy expert Dr. Stephan Grupp and pediatric hematologist Dr. Alexis Thompson join Madeline to talk about how gene therapy for sickle cell disease can transform patients’ lives. They also discuss what teams at Children’s Hospital of Philadelphia (CHOP) are doing to ensure that these innovative therapies reach the children who need them most. 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844.57q-12.571-130.857-105.429-223.714T142.857 515.43q-14.286-1.143-23.714-11.429t-9.429-24.571v-77.143q0-16.572 12-26.857 9.715-9.715 24.572-9.715h2.857q91.428 7.429 174.857 46T472 515.43q65.143 64.571 103.714 148t46 174.857z m292.572 1.143q1.143 15.428-10.286 26.857-10.286 11.428-26.286 11.428H796q-14.857 0-25.429-10T759.43 843.43Q752.57 720.57 701.714 610T569.43 418t-192-132.286T144 227.43q-14.286-0.572-24.286-11.143t-10-24.857v-81.715q0-16 11.429-26.285 10.286-10.286 25.143-10.286H148q149.714 7.428 286.571 68.571t243.143 168q106.857 106.286 168 243.143t68.572 286.572z" p-id="11611"></path></svg> RSS</a></div></div><p class="podcast-description fs-13 pt-4 pb-lg-5">Madeline Bell, CEO of the renowned Children’s Hospital of Philadelphia, takes you behind the scenes to meet the brilliant minds who are making - and supporting - incredible breakthroughs in pediatric medicine.</p></div></div></div><div class="col-12 col-lg-9 col-xl-10"><div><div class="container list-container"><h2 class="text-center cc-episode-title">Episodes</h2><div class="episode-list-type-list row row-cols-1 row-cols-md-4 pt-4 g-4 mt-0 episode-content cc-episode-list"><div class="col6 mt-0 card bg-transparent border-0 d-md-flex list"><div class="episode-logo position-relative" href="javascript:void(0)"><div class="e-logo"><img class="object-fit-cover" width="300" height="300" alt="Gene Therapy for Sickle Cell Disease" src="https://pbcdn1.podbean.com/imglogo/image-logo/2691026/Generic-Podbean-1080x1080-2x_t7wnw6_300x300.jpg" loading="lazy"></div><p class="e-l-date"><span class="episode-date">Monday Jun 17, 2024</span></p><div class="hover-bg"></div><div class="play-bg position-absolute d-flex align-items-center justify-content-center"><button type="button" class="btn btn-link play-button" title="Play Gene Therapy for Sickle Cell Disease"><span class="play-button-bg"><svg t="1622017593702" class="icon icon-play" fill="currentColor" viewbox="0 0 1024 1024" version="1.1" xmlns="http://www.w3.org/2000/svg" p-id="12170" width="30" height="30"><path d="M844.704269 475.730473L222.284513 116.380385a43.342807 43.342807 0 0 0-65.025048 37.548353v718.692951a43.335582 43.335582 0 0 0 65.025048 37.541128l622.412531-359.342864a43.357257 43.357257 0 0 0 0.007225-75.08948z" fill="" p-id="12171"></path></svg></span></button></div></div><div class="card-body position-relative"><div class="card-body-button-title"><button type="button" class="btn btn-link play-button e-r-play-button" title="Play Gene Therapy for Sickle Cell Disease"><span class="play-button-bg"><svg t="1622017593702" class="icon icon-play" fill="currentColor" viewbox="0 0 1024 1024" version="1.1" xmlns="http://www.w3.org/2000/svg" p-id="12170" width="30" height="30"><path d="M844.704269 475.730473L222.284513 116.380385a43.342807 43.342807 0 0 0-65.025048 37.548353v718.692951a43.335582 43.335582 0 0 0 65.025048 37.541128l622.412531-359.342864a43.357257 43.357257 0 0 0 0.007225-75.08948z" fill="" p-id="12171"></path></svg></span></button><div class="right-title-date"><h2 class="card-title e-title text-truncate"><a aria-current="page" href="/e/gene-therapy-for-sickle-cell-disease/" class="router-link-active router-link-exact-active text-decoration-none text-truncate">Gene Therapy for Sickle Cell Disease</a></h2><p class="r-t-date text-gray"><span class="episode-date">Monday Jun 17, 2024</span></p></div></div><p class="e-date text-gray"><span class="episode-date">Monday Jun 17, 2024</span></p><div class="episode-description"><p class="e-description text-two-line card-text"><p>Sickle cell disease is an inherited blood disorder that often causes debilitating pain and life-threatening complications. Many patients with the disease make dozens of ER visits a year, and must receive regular blood transfusions. And though recent breakthroughs in gene therapy are giving patients with sickle cell new hope – and new options – accessing these therapies can be challenging. In this episode of Breaking Through, cell and gene therapy expert Dr. Stephan Grupp and pediatric hematologist Dr. Alexis Thompson join Madeline to talk about how gene therapy for sickle cell disease can transform patients’ lives. They also discuss what teams at Children’s Hospital of Philadelphia (CHOP) are doing to ensure that these innovative therapies reach the children who need them most. </p></p></div><div class="cc-post-toolbar"><ul class="list-unstyled d-flex mb-0 row gx-5 p-0"><li class="col-auto"><button class="border-0 p-0 bg-transparent row gx-1 align-items-center" title="Likes"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-heart col-auto icon-like" viewbox="0 0 16 16"><path d="m8 2.748-.717-.737C5.6.281 2.514.878 1.4 3.053c-.523 1.023-.641 2.5.314 4.385.92 1.815 2.834 3.989 6.286 6.357 3.452-2.368 5.365-4.542 6.286-6.357.955-1.886.838-3.362.314-4.385C13.486.878 10.4.28 8.717 2.01L8 2.748zM8 15C-7.333 4.868 3.279-3.04 7.824 1.143c.06.055.119.112.176.171a3.12 3.12 0 0 1 .176-.17C12.72-3.042 23.333 4.867 8 15z"></path></svg><span class="text-gray col-auto item-name">Likes</span></button></li><li class="col-auto"><a class="border-0 p-0 bg-transparent row 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