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class="vector-toc-link" href="#Chimie"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Chimie</span> </div> </a> <ul id="toc-Chimie-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Pharmacologie" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Pharmacologie"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Pharmacologie</span> </div> </a> <button aria-controls="toc-Pharmacologie-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Afficher / masquer la sous-section Pharmacologie</span> </button> <ul id="toc-Pharmacologie-sublist" class="vector-toc-list"> <li id="toc-Mécanisme_d’action" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Mécanisme_d’action"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Mécanisme d’action</span> </div> </a> <ul id="toc-Mécanisme_d’action-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Contre_indication" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Contre_indication"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Contre indication</span> </div> </a> <ul id="toc-Contre_indication-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Effets_secondaires" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Effets_secondaires"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Effets secondaires</span> </div> </a> <button aria-controls="toc-Effets_secondaires-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Afficher / masquer la sous-section Effets secondaires</span> </button> <ul id="toc-Effets_secondaires-sublist" class="vector-toc-list"> <li id="toc-Effets_secondaires_fréquents" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Effets_secondaires_fréquents"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>Effets secondaires fréquents</span> </div> </a> <ul id="toc-Effets_secondaires_fréquents-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Effets_secondaires_rares" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Effets_secondaires_rares"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2</span> <span>Effets secondaires rares</span> </div> </a> <ul id="toc-Effets_secondaires_rares-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Effets_secondaires_possible_et_éventuels" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Effets_secondaires_possible_et_éventuels"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.3</span> <span>Effets secondaires possible et éventuels</span> </div> </a> <ul id="toc-Effets_secondaires_possible_et_éventuels-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Accoutumance_-_Tolérance_-_Dépendance" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Accoutumance_-_Tolérance_-_Dépendance"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Accoutumance - Tolérance - Dépendance</span> </div> </a> <ul id="toc-Accoutumance_-_Tolérance_-_Dépendance-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Pharmacocinétique_et_devenir_dans_l’organisme" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Pharmacocinétique_et_devenir_dans_l’organisme"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Pharmacocinétique et devenir dans l’organisme</span> </div> </a> <ul id="toc-Pharmacocinétique_et_devenir_dans_l’organisme-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Voir_aussi" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Voir_aussi"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Voir aussi</span> </div> </a> <button aria-controls="toc-Voir_aussi-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Afficher / masquer la sous-section Voir aussi</span> </button> <ul id="toc-Voir_aussi-sublist" class="vector-toc-list"> <li id="toc-Articles_connexes" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Articles_connexes"> <div class="vector-toc-text"> <span class="vector-toc-numb">8.1</span> <span>Articles connexes</span> </div> </a> <ul id="toc-Articles_connexes-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Liens_externes" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Liens_externes"> <div class="vector-toc-text"> <span class="vector-toc-numb">8.2</span> <span>Liens externes</span> </div> </a> <ul id="toc-Liens_externes-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Notes_et_références" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Notes_et_références"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>Notes et références</span> </div> </a> <ul id="toc-Notes_et_références-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sommaire" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Basculer la table des matières" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Basculer la table des matières</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Témazépam</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Aller à un article dans une autre langue. Disponible en 24 langues." > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-24" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">24 langues</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%AA%D9%8A%D9%85%D8%A7%D8%B2%D9%8A%D8%A8%D8%A7%D9%85" title="تيمازيبام – arabe" lang="ar" hreflang="ar" data-title="تيمازيبام" data-language-autonym="العربية" data-language-local-name="arabe" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D8%AA%D9%85%D8%A7%D8%B2%D9%BE%D8%A7%D9%85" title="تمازپام – South Azerbaijani" lang="azb" hreflang="azb" data-title="تمازپام" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%A4%E0%A7%87%E0%A6%AE%E0%A6%BE%E0%A6%9C%E0%A6%BF%E0%A6%AA%E0%A6%BE%E0%A6%AE" title="তেমাজিপাম – bengali" lang="bn" hreflang="bn" data-title="তেমাজিপাম" data-language-autonym="বাংলা" data-language-local-name="bengali" class="interlanguage-link-target"><span>বাংলা</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Temazepam" title="Temazepam – tchèque" lang="cs" hreflang="cs" data-title="Temazepam" data-language-autonym="Čeština" data-language-local-name="tchèque" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Temasepam" title="Temasepam – gallois" lang="cy" hreflang="cy" data-title="Temasepam" data-language-autonym="Cymraeg" data-language-local-name="gallois" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Temazepam" title="Temazepam – allemand" lang="de" hreflang="de" data-title="Temazepam" data-language-autonym="Deutsch" data-language-local-name="allemand" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Temazepam" title="Temazepam – anglais" lang="en" hreflang="en" data-title="Temazepam" data-language-autonym="English" data-language-local-name="anglais" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Temazepam" title="Temazepam – espagnol" lang="es" hreflang="es" data-title="Temazepam" data-language-autonym="Español" data-language-local-name="espagnol" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%AA%D9%85%D8%A7%D8%B2%D9%BE%D8%A7%D9%85" title="تمازپام – persan" lang="fa" hreflang="fa" data-title="تمازپام" data-language-autonym="فارسی" data-language-local-name="persan" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Tematsepaami" title="Tematsepaami – finnois" lang="fi" hreflang="fi" data-title="Tematsepaami" data-language-autonym="Suomi" data-language-local-name="finnois" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Temacepam" title="Temacepam – galicien" lang="gl" hreflang="gl" data-title="Temacepam" data-language-autonym="Galego" data-language-local-name="galicien" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Temazepam" title="Temazepam – croate" lang="hr" hreflang="hr" data-title="Temazepam" data-language-autonym="Hrvatski" data-language-local-name="croate" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Temazepam" title="Temazepam – italien" lang="it" hreflang="it" data-title="Temazepam" data-language-autonym="Italiano" data-language-local-name="italien" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%86%E3%83%9E%E3%82%BC%E3%83%91%E3%83%A0" title="テマゼパム – japonais" lang="ja" hreflang="ja" data-title="テマゼパム" data-language-autonym="日本語" data-language-local-name="japonais" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Temazepam" title="Temazepam – néerlandais" lang="nl" hreflang="nl" data-title="Temazepam" data-language-autonym="Nederlands" data-language-local-name="néerlandais" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Temazepam" title="Temazepam – norvégien bokmål" lang="nb" hreflang="nb" data-title="Temazepam" data-language-autonym="Norsk bokmål" data-language-local-name="norvégien bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%9F%E0%AD%87%E0%AC%AE%E0%AC%BE%E0%AC%9C%E0%AD%87%E0%AC%AA%E0%AC%BE%E0%AC%AE" title="ଟେମାଜେପାମ – odia" lang="or" hreflang="or" data-title="ଟେମାଜେପାମ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Temazepam" title="Temazepam – polonais" lang="pl" hreflang="pl" data-title="Temazepam" data-language-autonym="Polski" data-language-local-name="polonais" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Temazepam" title="Temazepam – portugais" lang="pt" hreflang="pt" data-title="Temazepam" data-language-autonym="Português" data-language-local-name="portugais" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Temazepam" title="Temazepam – roumain" lang="ro" hreflang="ro" data-title="Temazepam" data-language-autonym="Română" data-language-local-name="roumain" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A2%D0%B5%D0%BC%D0%B0%D0%B7%D0%B5%D0%BF%D0%B0%D0%BC" title="Темазепам – russe" lang="ru" hreflang="ru" data-title="Темазепам" data-language-autonym="Русский" data-language-local-name="russe" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Temazepam" title="Temazepam – serbo-croate" lang="sh" hreflang="sh" data-title="Temazepam" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croate" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Temazepam" title="Temazepam – serbe" lang="sr" hreflang="sr" data-title="Temazepam" data-language-autonym="Српски / srpski" data-language-local-name="serbe" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Temazepam" title="Temazepam – suédois" lang="sv" hreflang="sv" data-title="Temazepam" data-language-autonym="Svenska" data-language-local-name="suédois" class="interlanguage-link-target"><span>Svenska</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q414796#sitelinks-wikipedia" title="Modifier les liens interlangues" class="wbc-editpage">Modifier les liens</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div 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style="background-color:#FFDEAD;color:black;">Témazépam </td></tr> <tr><td colspan="2" style="text-align:center; line-height: 1.5em;"><span typeof="mw:File/Frameless"><a href="/w/index.php?title=Fichier:Temazepam.svg&lang=fr" class="mw-file-description"><img alt="Image illustrative de l’article Témazépam" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/63/Temazepam.svg/langfr-200px-Temazepam.svg.png" decoding="async" width="200" height="184" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/63/Temazepam.svg/langfr-300px-Temazepam.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/63/Temazepam.svg/langfr-400px-Temazepam.svg.png 2x" data-file-width="512" data-file-height="471" /></a></span> </td></tr> <tr> <td colspan="3" style="text-align:center; line-height: 1.5em;"><span typeof="mw:File/Frameless"><a href="/wiki/Fichier:Temazepam-3D-ball-model.png" class="mw-file-description"><img alt="Image illustrative de l’article Témazépam" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/63/Temazepam-3D-ball-model.png/160px-Temazepam-3D-ball-model.png" decoding="async" width="160" height="183" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/63/Temazepam-3D-ball-model.png/240px-Temazepam-3D-ball-model.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/63/Temazepam-3D-ball-model.png/320px-Temazepam-3D-ball-model.png 2x" data-file-width="1095" data-file-height="1250" /></a></span> </td></tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#FFDEAD; color:#000000">Identification</th></tr> <tr> <th scope="row"><a href="/wiki/D%C3%A9nomination_commune_internationale" title="Dénomination commune internationale">DCI</a> </th> <td>Témazépam </td> </tr> <tr> <th scope="row"><a href="/wiki/Nomenclature_de_l%27UICPA" title="Nomenclature de l'UICPA">Nom UICPA</a> </th> <td><small>7-chloro-3-hydroxy-1-méthyl-5-phényl-2,3-dihydro-1H-benzo[f]-1,4-diazépin-2-one</small> </td> </tr> <tr> <th scope="row"><a href="/wiki/Num%C3%A9ro_CAS" title="Numéro CAS">N<sup>o</sup> CAS</a> </th> <td><span class="reflink plainlinksneverexpand"><span class="noarchive"><a class="external text" href="//tools.wmflabs.org/magnustools/cas.php?cas=846-50-4&language=fr&title=Témazépam">846-50-4</a></span></span> </td> </tr> <tr> <th scope="row"> N<sup>o</sup> <a href="/wiki/Agence_europ%C3%A9enne_des_produits_chimiques" title="Agence européenne des produits chimiques">ECHA</a> </th> <td><span class="plainlinks"><span class="noarchive"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.011.535">100.011.535</a></span></span></td> </tr> <tr> <th scope="row"><a href="/wiki/Num%C3%A9ro_CE" title="Numéro CE">N<sup>o</sup> CE</a> </th> <td>212-688-1 </td> </tr> <tr> <th scope="row"><a href="/wiki/Classification_ATC" title="Classification ATC">Code ATC</a> </th> <td><a href="/wiki/Classe_ATC_N05" title="Classe ATC N05"><span title="NERVOUS SYSTEM, PSYCHOLEPTICS, HYPNOTICS AND SEDATIVES, Benzodiazepine derivatives, temazepam">N05</span></a><span class="reflink plainlinksneverexpand"><span class="noarchive"><a rel="nofollow" class="external text" href="http://www.whocc.no/atc_ddd_index/?code=N05CD07">CD07</a></span></span> </td> </tr> <tr> <th scope="row"><a href="/wiki/Simplified_Molecular_Input_Line_Entry_System" title="Simplified Molecular Input Line Entry System">SMILES</a> </th> <td><div class="NavFrame" title="[Afficher]/[Masquer]" style="border: none; padding: 0;"><div class="NavContent" style="display: none; text-align: left;">c12C(c3ccccc3)=N[C@@H](O)C(N(c1ccc(c2)Cl)C)=O <br /><span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://pubchem.ncbi.nlm.nih.gov/search/?smarts=c12C%28c3ccccc3%29%3DN%5BC%40%40H%5D%28O%29C%28N%28c1ccc%28c2%29Cl%29C%29%3DO">PubChem</a></span>, <span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://chemapps.stolaf.edu/jmol/jmol.php?title=T%C3%A9maz%C3%A9pam&model=c12C%28c3ccccc3%29%3DN%5BC%40%40H%5D%28O%29C%28N%28c1ccc%28c2%29Cl%29C%29%3DO">vue 3D</a></span></div></div> </td> </tr> <tr> <th scope="row"><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a> </th> <td><div class="NavFrame" title="[Afficher]/[Masquer]" style="border: none; padding: 0;"><div class="NavContent" style="display: none; text-align: left;"><b>InChI :</b> <span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://chemapps.stolaf.edu/jmol/jmol.php?title=T%C3%A9maz%C3%A9pam&model=InChI%3D1%2FC16H13ClN2O2%2Fc1-19-13-8-7-11%2817%299-12%2813%2914%2818-15%2820%2916%2819%2921%2910-5-3-2-4-6-10%2Fh2-9%2C15%2C20H%2C1H3">vue 3D</a></span> <br />InChI=1/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3 <br /><b>Std. InChIKey :</b> <br />Æ</div></div> </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#FFDEAD; color:#000000">Propriétés chimiques</th></tr> <tr> <th scope="row"><a href="/wiki/Formule_chimique" title="Formule chimique">Formule</a> </th> <td><a href="/wiki/Carbone" title="Carbone">C</a><sub>16</sub><a href="/wiki/Hydrog%C3%A8ne" title="Hydrogène">H</a><sub>13</sub><a href="/wiki/Chlore" title="Chlore">Cl</a><a href="/wiki/Azote" title="Azote">N</a><sub>2</sub><a href="/wiki/Oxyg%C3%A8ne" title="Oxygène">O</a><sub>2</sub>  <span class="page_h"><a href="/wiki/C16H13ClN2O2" class="mw-disambig" title="C16H13ClN2O2"><small>[Isomères]</small></a></span><br /> </td> </tr> <tr> <th scope="row"><a href="/wiki/Masse_molaire" title="Masse molaire">Masse molaire</a><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite_crochet">[</span>1<span class="cite_crochet">]</span></a></sup> </th> <td>300,74 ± 0,017 <a href="/wiki/Gramme" title="Gramme">g</a>/<a href="/wiki/Mole_(unit%C3%A9)" title="Mole (unité)">mol</a> <br /><small>C 63,9 %,  H 4,36 %,  Cl 11,79 %,  N 9,31 %,  O 10,64 %,  </small> </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#f7efa8; color:#000000">Propriétés physiques</th></tr> <tr> <th scope="row"><a href="/wiki/Point_de_fusion" title="Point de fusion"><abbr class="abbr" title="Température">T°</abbr> fusion</a> </th> <td><span title="246,2 °F ou 392,2 K">119</span> à <span title="249,8 °F ou 394,2 K">121 </span><abbr class="abbr" title="degré Celsius">°C</abbr> </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#ffb4b4; color:#000000">Précautions</th></tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#eeeeee; color:#000000">Classification du <a href="/wiki/Centre_international_de_recherche_sur_le_cancer" title="Centre international de recherche sur le cancer">CIRC</a></th></tr> <tr> <td colspan="2" style="text-align:left;">Groupe 3 : Inclassable quant à sa cancérogénicité pour l'Homme<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite_crochet">[</span>2<span class="cite_crochet">]</span></a></sup></td> </tr><tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#DDFFDD; color:#000000">Données pharmacocinétiques</th></tr> <tr> <th scope="row"><a href="/wiki/Biodisponibilit%C3%A9_(m%C3%A9decine)" title="Biodisponibilité (médecine)">Biodisponibilité</a> </th> <td>80 % </td> </tr> <tr> <th scope="row">Liaison protéique </th> <td>95 % </td> </tr> <tr> <th scope="row"><a href="/wiki/Demi-vie" title="Demi-vie">Demi-vie d’<abbr class="abbr" title="élimination">élim.</abbr></a> </th> <td>heures 8-9 h </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#DDFFDD; color:#000000">Considérations thérapeutiques</th></tr> <tr> <th scope="row">Classe thérapeutique </th> <td><a href="/wiki/Benzodiaz%C3%A9pine" title="Benzodiazépine">Benzodiazépine</a> </td> </tr> <tr> <th scope="row"><a href="/wiki/Pr%C3%A9vention_et_s%C3%A9curit%C3%A9_routi%C3%A8res" title="Prévention et sécurité routières">Conduite automobile</a> </th> <td>Proscrite </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#f2f2aa; color:#000000">Caractère psychotrope</th></tr> <tr> <th scope="row"><a href="/wiki/Classification_des_psychotropes" title="Classification des psychotropes">Catégorie</a> </th> <td><a href="/wiki/Hypnotique" title="Hypnotique">hypnotique</a> </td> </tr> <tr> <th scope="row">Mode de consommation </th> <td> <p>orale </p> </td> </tr> <tr> <th scope="row">Risque de dépendance </th> <td>Élevé </td> </tr> <tr> <td colspan="2"><hr style="height:2px; background-color:#FFDEAD;" /></td></tr> <tr> <td colspan="2" style="text-align:center;">Unités du <a href="/wiki/Syst%C3%A8me_international_d%27unit%C3%A9s" title="Système international d'unités">SI</a> et <a href="/wiki/Conditions_normales_de_temp%C3%A9rature_et_de_pression" title="Conditions normales de température et de pression"><abbr title="conditions normales de température et de pression">CNTP</abbr></a>, sauf indication contraire.</td> </tr><tr> <td class="navigation-only" colspan="2" style="border-top: 2px #FFDEAD solid; font-size: 80%; background:inherit; color: inherit; text-align: right;"><span class="plainlinks" style="float:left;"><a class="external text" href="https://fr.wikipedia.org/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=0"><span class="infodoc">modifier</span></a></span> <span typeof="mw:File"><a href="/wiki/Mod%C3%A8le:Infobox_Chimie" title="Consultez la documentation du modèle"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/12px-Info_Simple.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/18px-Info_Simple.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/24px-Info_Simple.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span></td> </tr> </tbody></table> <p>Le <b>témazépam</b> est une substance chimique de la famille des <a href="/wiki/Benzodiaz%C3%A9pine" title="Benzodiazépine">benzodiazépines</a> commercialisée notamment sous le nom de <i>Normison</i> en France (d'autres spécialités existent comme <i>Euhypnos</i>, <i>Levanxol</i>, <i>Planum</i>, <i>Restoril</i>). Comme toutes les substances de cette famille, elle possède des propriétés <a href="/wiki/Anxiolytique" title="Anxiolytique">anxiolytiques</a>, <a href="/wiki/Hypnotique" title="Hypnotique">hypnotiques</a> ou <a href="/wiki/S%C3%A9datif" title="Sédatif">sédatives</a>, <a href="/wiki/Anticonvulsant" class="mw-redirect" title="Anticonvulsant">anticonvulsantes</a>, et <a href="/wiki/Myorelaxant" title="Myorelaxant">myorelaxantes</a>, mais elle est surtout prescrite comme <a href="/wiki/Hypnotique" title="Hypnotique">hypnotique</a> dans le traitement à court terme d'<a href="/wiki/Insomnie" title="Insomnie">insomnie</a> sévère (difficultés d'endormissement) lorsque d'autres traitements, notamment des règles hygiéno-diététiques, ont échoué. </p><p>En France, le <b>Normison</b> a connu un arrêt de commercialisation depuis 2013 à la suite de la fermeture du laboratoire le fabriquant (Alkopharm/Génopharm). Aucun générique n’était disponible, cependant la société Primius Lab Limited avait récupéré les droits de commercialisation du Normison. Il a par la suite été une nouvelle fois retiré du marché<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite_crochet">[</span>3<span class="cite_crochet">]</span></a></sup>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Historique">Historique</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=1" title="Modifier la section : Historique" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=1" title="Modifier le code source de la section : Historique"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Le témazépam a été d'abord synthétisé en 1964, mais il a été utilisé en 1969 pour sa capacité à traiter l'insomnie<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite_crochet">[</span>4<span class="cite_crochet">]</span></a></sup>. À la fin des années 1980, le témazépam était un des <a href="/wiki/Somnif%C3%A8re" class="mw-redirect" title="Somnifère">somnifères</a> les plus vendus et largement disponible sur le marché : c'est devenu un des médicaments les plus largement prescrits. </p> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/Fichier:Boite_de_Normison_(T%C3%A9maz%C3%A9pam).jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7d/Boite_de_Normison_%28T%C3%A9maz%C3%A9pam%29.jpg/220px-Boite_de_Normison_%28T%C3%A9maz%C3%A9pam%29.jpg" decoding="async" width="220" height="258" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7d/Boite_de_Normison_%28T%C3%A9maz%C3%A9pam%29.jpg/330px-Boite_de_Normison_%28T%C3%A9maz%C3%A9pam%29.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7d/Boite_de_Normison_%28T%C3%A9maz%C3%A9pam%29.jpg/440px-Boite_de_Normison_%28T%C3%A9maz%C3%A9pam%29.jpg 2x" data-file-width="1066" data-file-height="1249" /></a><figcaption>Boite de Normison (Témazépam)</figcaption></figure> <div class="mw-heading mw-heading2"><h2 id="Chimie">Chimie</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=2" title="Modifier la section : Chimie" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=2" title="Modifier le code source de la section : Chimie"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading2"><h2 id="Pharmacologie">Pharmacologie</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=3" title="Modifier la section : Pharmacologie" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=3" title="Modifier le code source de la section : Pharmacologie"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Mécanisme_d’action"><span id="M.C3.A9canisme_d.E2.80.99action"></span>Mécanisme d’action</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=4" title="Modifier la section : Mécanisme d’action" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=4" title="Modifier le code source de la section : Mécanisme d’action"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Il agit d'une manière similaire aux autres molécules de la classe des <a href="/wiki/Benzodiaz%C3%A9pine" title="Benzodiazépine">benzodiazépines</a>, à savoir sur les <a href="/wiki/R%C3%A9cepteur_GABAA" title="Récepteur GABAA">récepteurs GABA</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Contre_indication">Contre indication</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=5" title="Modifier la section : Contre indication" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=5" title="Modifier le code source de la section : Contre indication"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Comme toutes les benzodiazépines, le témazépam ne doit pas être utilisé en cas d'hypersensibilité aux benzodiazépines : </p> <ul><li><a href="/wiki/Insuffisance_respiratoire" title="Insuffisance respiratoire">insuffisance respiratoire</a> sévère</li> <li><a href="/wiki/Myasth%C3%A9nie" title="Myasthénie">myasthénie</a></li> <li>association à l'<a href="/wiki/Boisson_alcoolis%C3%A9e" title="Boisson alcoolisée">alcool</a>  : risque de potentialisation et de cumul pouvant causer des problèmes graves</li> <li>grossesse (trois premiers mois) : risque tératogène non évalué.</li> <li>grossesse (dernier trimestre) : risque d'intoxication ou de syndrome de sevrage du nouveau-né.</li> <li>allaitement</li> <li><span class="page_h"><a href="/wiki/Insuffisance_r%C3%A9nale" class="mw-disambig" title="Insuffisance rénale">insuffisance rénale</a></span> sévère (notamment patients en dialyse)</li> <li><a href="/wiki/Insuffisance_h%C3%A9patique" class="mw-redirect" title="Insuffisance hépatique">insuffisance hépatique</a> sévère</li></ul> <p>On devrait éviter l'utilisation du témazépam, en cas de : </p> <ul><li><a href="/wiki/Ataxie" title="Ataxie">Ataxie</a></li> <li><a href="/wiki/Hypoventilation" title="Hypoventilation">Hypoventilation</a> sévère</li> <li><a href="/wiki/Glaucome" title="Glaucome">Glaucome</a> de l'angle étroit aigu</li> <li><a href="/wiki/D%C3%A9pression_nerveuse" class="mw-redirect" title="Dépression nerveuse">dépression</a> grave, particulièrement lorsqu'elle s'accompagne de tendances <a href="/wiki/Suicide" title="Suicide">suicidaires</a></li> <li>chez les enfants de moins de 15 ans</li></ul> <p>En outre l'usage de boissons alcoolisées est fortement déconseillé, comme avec d'autres substances psychoactives. </p> <div class="mw-heading mw-heading2"><h2 id="Effets_secondaires">Effets secondaires</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=6" title="Modifier la section : Effets secondaires" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=6" title="Modifier le code source de la section : Effets secondaires"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Les effets secondaires de la témazépam sont ceux des benzodiazépines et sont en relation avec le <a href="/wiki/Syst%C3%A8me_nerveux_central" title="Système nerveux central">système nerveux central</a> </p> <div class="mw-heading mw-heading3"><h3 id="Effets_secondaires_fréquents"><span id="Effets_secondaires_fr.C3.A9quents"></span>Effets secondaires fréquents</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=7" title="Modifier la section : Effets secondaires fréquents" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=7" title="Modifier le code source de la section : Effets secondaires fréquents"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>L'effet le plus important est la <a href="/wiki/Somnolence" class="mw-redirect" title="Somnolence">somnolence</a> </p> <div class="mw-heading mw-heading3"><h3 id="Effets_secondaires_rares">Effets secondaires rares</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=8" title="Modifier la section : Effets secondaires rares" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=8" title="Modifier le code source de la section : Effets secondaires rares"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Les effets secondaires peuvent inclure<sup id="cite_ref-pmid38627_5-0" class="reference"><a href="#cite_note-pmid38627-5"><span class="cite_crochet">[</span>5<span class="cite_crochet">]</span></a></sup> : </p> <ul><li><a href="/wiki/Asth%C3%A9nie" title="Asthénie">asthénie</a> (fatigue)</li> <li><a href="/wiki/Ataxie" title="Ataxie">ataxie</a></li> <li><a href="/wiki/Prurit" title="Prurit">prurit</a></li> <li>confusion mentale</li> <li><a href="/wiki/Vertige" title="Vertige">vertige</a>,</li> <li>difficultés de <a href="/wiki/M%C3%A9moire_(psychologie)" title="Mémoire (psychologie)">mémorisation</a>,</li> <li>l'excitation paradoxale,</li> <li>l'<a href="/wiki/Amn%C3%A9sie_ant%C3%A9rograde" title="Amnésie antérograde">amnésie antérograde</a></li> <li>lenteur des réactions, rendant la conduite automobile ou l'utilisation de machine impossible et dangereuse</li></ul> <p>D'autres effets secondaires peuvent subvenir comme : </p> <ul><li>des <a href="/wiki/C%C3%A9phal%C3%A9e" title="Céphalée">céphalées</a></li> <li>une <a href="/wiki/Diarrh%C3%A9e" title="Diarrhée">diarrhée</a></li></ul> <p>Une dose plus importante peut induire une <a href="/wiki/D%C3%A9pression_respiratoire" title="Dépression respiratoire">dépression respiratoire</a> </p><p>D'autre part, comme beaucoup de <a href="/wiki/M%C3%A9dicament_psychotrope" title="Médicament psychotrope">médicaments psychotropes</a> le témazépam induit une <a href="/wiki/Accoutumance" title="Accoutumance">accoutumance</a> et une <a href="/wiki/Addiction" title="Addiction">dépendance</a> qui peuvent poser un problème en cas de <b> <a href="/wiki/Sevrage_(toxicologie)" title="Sevrage (toxicologie)">sevrage</a></b>, surtout <b>brutal</b> qui peuvent se traduire par des crampes musculaires et abdominales, des convulsions, une dépression, une <a href="/wiki/Insomnie" title="Insomnie">insomnie</a> dite de rebond, une transpiration excessive, des tremblements, des vomissements. </p> <div class="mw-heading mw-heading3"><h3 id="Effets_secondaires_possible_et_éventuels"><span id="Effets_secondaires_possible_et_.C3.A9ventuels"></span>Effets secondaires possible et éventuels</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=9" title="Modifier la section : Effets secondaires possible et éventuels" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=9" title="Modifier le code source de la section : Effets secondaires possible et éventuels"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>D'autres effets plus rares ont été rapportés (moins de 0.5 %): </p> <ul><li><a href="/wiki/Hyperhidrose" title="Hyperhidrose">hyperhidrose</a>,</li> <li>modification de la <a href="/wiki/D%C3%A9sir_sexuel" title="Désir sexuel">libido</a></li> <li>des hallucinations</li> <li>un <a href="/wiki/Nystagmus" title="Nystagmus">nystagmus</a></li> <li>des vomissements</li> <li>des troubles gastro-intestinaux</li> <li>des cauchemars,</li> <li>des réactions paradoxales  : agitation, agressivité voire violence, excitation ,</li></ul> <p>Cette molécule a une action rapide et est dosée le plus souvent dans des médicaments <a href="/wiki/Somnif%C3%A8re" class="mw-redirect" title="Somnifère">somnifères</a>. De fait, après la prise de celle-ci, il peut résulter un état d'hébétude, de somnolence, une diminution des fonctions psychomotrices et cognitives peuvent persister le jour suivant, qui peut augmenter le risque d'accidents de la circulation ou de chutes<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite_crochet">[</span>6<span class="cite_crochet">]</span></a></sup>. C'est pourquoi les spécialités pharmaceutiques portent un pictogramme (danger de risque 3 : ne pas conduire après la prise) sur les boîtes. </p><p>La prise de boissons alcoolisées en même temps que le traitement est dangereuse et peut provoquer la mort. </p> <div class="mw-heading mw-heading2"><h2 id="Accoutumance_-_Tolérance_-_Dépendance"><span id="Accoutumance_-_Tol.C3.A9rance_-_D.C3.A9pendance"></span>Accoutumance - Tolérance - Dépendance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=10" title="Modifier la section : Accoutumance - Tolérance - Dépendance" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=10" title="Modifier le code source de la section : Accoutumance - Tolérance - Dépendance"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Tout comme les autres produits de sa classe, il présente un potentiel addictif important si consommé quotidiennement. </p> <div class="mw-heading mw-heading2"><h2 id="Pharmacocinétique_et_devenir_dans_l’organisme"><span id="Pharmacocin.C3.A9tique_et_devenir_dans_l.E2.80.99organisme"></span>Pharmacocinétique et devenir dans l’organisme</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=11" title="Modifier la section : Pharmacocinétique et devenir dans l’organisme" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=11" title="Modifier le code source de la section : Pharmacocinétique et devenir dans l’organisme"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>L'administration orale de 15 à <span class="nowrap"><span title="">45</span> <span title="milligramme">mg</span></span> de témazépam est rapidement absorbée en moins de 30 minutes ; le <a href="/w/index.php?title=Pic_plasmatique&action=edit&redlink=1" class="new" title="Pic plasmatique (page inexistante)">pic plasmatique</a> est atteint en un peu plus d'une heure et demie. Il n'y a aucun <a href="/wiki/Catabolite" class="mw-redirect" title="Catabolite">catabolite</a> actif formé (le seul catabolite significatif dans le sang était l'O-conjugate). La dégradation dans le corps humain du médicament indique une demi-vie courte d'environ 8,8 heures<sup id="cite_ref-pmid2891534_7-0" class="reference"><a href="#cite_note-pmid2891534-7"><span class="cite_crochet">[</span>7<span class="cite_crochet">]</span></a></sup> La <a href="/wiki/Biodisponibilit%C3%A9_(m%C3%A9decine)" title="Biodisponibilité (médecine)">biodisponibilité</a> du témazépam est de presque 100 % par l'intestin. La substance est transformée par métabolisme par la conjugaison et déméthylation avant l'excrétion. La plupart de la molécule est excrétée dans l'urine et 20 % par les fèces. Le catabolite important était l'O-conjugate de témazépam (90 %) ; l'O-conjugate de N-desméthyl témazepam était un métabolite mineur (7 %)<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite_crochet">[</span>8<span class="cite_crochet">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Voir_aussi">Voir aussi</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=12" title="Modifier la section : Voir aussi" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=12" title="Modifier le code source de la section : Voir aussi"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Articles_connexes">Articles connexes</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=13" title="Modifier la section : Articles connexes" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=13" title="Modifier le code source de la section : Articles connexes"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Benzodiaz%C3%A9pine" title="Benzodiazépine">Benzodiazépines</a> et <a href="/wiki/D%C3%A9presseur" title="Dépresseur">dépresseur</a></li> <li><a href="/wiki/Insomnie" title="Insomnie">Insomnie</a></li> <li><a href="/wiki/Sommeil" title="Sommeil">Sommeil</a></li> <li><a href="/wiki/M%C3%A9dicament_psychotrope" title="Médicament psychotrope">Médicament psychotrope</a></li> <li><a href="/wiki/Hypnotique" title="Hypnotique">hypnotique</a> et <a href="/wiki/S%C3%A9datif" title="Sédatif">sédatif</a></li> <li><a href="/wiki/Addiction" title="Addiction">Addiction</a> et <a href="/wiki/Sevrage_(toxicologie)" title="Sevrage (toxicologie)">sevrage (toxicologie)</a></li></ul> <div class="mw-heading mw-heading3"><h3 id="Liens_externes">Liens externes</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=14" title="Modifier la section : Liens externes" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=14" title="Modifier le code source de la section : Liens externes"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Compendium suisse des médicaments : spécialités contenant <a rel="nofollow" class="external text" href="http://compendium.ch/search/all/temazepam/startwith/fr">Témazépam</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Notes_et_références"><span id="Notes_et_r.C3.A9f.C3.A9rences"></span>Notes et références</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&veaction=edit&section=15" title="Modifier la section : Notes et références" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=T%C3%A9maz%C3%A9pam&action=edit&section=15" title="Modifier le code source de la section : Notes et références"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink noprint"><a href="#cite_ref-1">↑</a> </span><span class="reference-text">Masse molaire calculée d’après <span class="ouvrage">« <a rel="nofollow" class="external text" href="http://www.chem.qmul.ac.uk/iupac/AtWt/"><cite style="font-style:normal;"><span class="lang-en" lang="en">Atomic weights of the elements 2007</span></cite></a> », sur <span class="italique">www.chem.qmul.ac.uk</span></span>.</span> </li> <li id="cite_note-2"><span class="mw-cite-backlink noprint"><a href="#cite_ref-2">↑</a> </span><span class="reference-text"><span class="ouvrage" id="Working_Group_on_the_Evaluation_of_Carcinogenic_Risks_to_Humans2009"><span class="ouvrage" id="IARC_Working_Group_on_the_Evaluation_of_Carcinogenic_Risks_to_Humans2009">IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, <span class="noarchive">« <a rel="nofollow" class="external text" href="http://monographs.iarc.fr/FR/Classification/crthgr03list.php"><cite style="font-style:normal; color:var(--color-link-red, #d73333);">Evaluations Globales de la Cancérogénicité pour l'Homme, Groupe 3 : Inclassables quant à leur cancérogénicité pour l'Homme</cite></a> »<sup class="plainlinks">(<a rel="nofollow" class="external text" href="https://web.archive.org/web/*/http://monographs.iarc.fr/FR/Classification/crthgr03list.php">Archive.org</a> • <a rel="nofollow" class="external text" href="https://archive.wikiwix.com/cache/?url=http://monographs.iarc.fr/FR/Classification/crthgr03list.php">Wikiwix</a> • <a rel="nofollow" class="external text" href="https://archive.is/http://monographs.iarc.fr/FR/Classification/crthgr03list.php">Archive.is</a> • <a rel="nofollow" class="external text" href="https://webcache.googleusercontent.com/search?hl=fr&q=cache:http://monographs.iarc.fr/FR/Classification/crthgr03list.php">Google</a> • <a href="/wiki/Projet:Correction_des_liens_externes#J'ai_trouvé_un_lien_mort,_que_faire_?" title="Projet:Correction des liens externes">Que faire ?</a>)</sup></span>, sur <span class="italique"><a rel="nofollow" class="external free" href="http://monographs.iarc.fr">http://monographs.iarc.fr</a></span>, CIRC, <time class="nowrap" datetime="2009-01-16" data-sort-value="2009-01-16">16 janvier 2009</time> <small style="line-height:1em;">(consulté le <time class="nowrap" datetime="2009-08-22" data-sort-value="2009-08-22">22 août 2009</time>)</small></span></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink noprint"><a href="#cite_ref-3">↑</a> </span><span class="reference-text"><span class="ouvrage">« <a rel="nofollow" class="external text" href="http://sante.lefigaro.fr/medicaments/3608587-normison-20mg-cpr-7"><cite style="font-style:normal;">Normison 20 mg, comprimé, pilulier de 7</cite></a> », sur <span class="italique">sante.lefigaro.fr</span> <small style="line-height:1em;">(consulté le <time class="nowrap" datetime="2020-01-24" data-sort-value="2020-01-24">24 janvier 2020</time>)</small></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink noprint"><a href="#cite_ref-4">↑</a> </span><span class="reference-text"><span class="ouvrage" id="C1969"><span class="ouvrage" id="Maggini_C1969"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Maggini C, « <cite style="font-style:normal" lang="en">Evaluation of the effectiveness of temazepam on the insomnia of patients with neurosis and endogenous depression</cite> », <i><span class="lang-en" lang="en">Arzneimittelforschung</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 19, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 10,‎ <time class="nowrap" datetime="1969-10" data-sort-value="1969-10">octobre 1969</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">1647–52</span> <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/4311716">4311716</a></span>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evaluation+of+the+effectiveness+of+temazepam+on+the+insomnia+of+patients+with+neurosis+and+endogenous+depression&rft.jtitle=Arzneimittelforschung&rft.issue=10&rft.aulast=C&rft.aufirst=Maggini&rft.date=1969-10&rft.volume=19&rft.pages=1647%E2%80%9352&rft_id=info%3Apmid%2F4311716&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AT%C3%A9maz%C3%A9pam"></span></span></span></span> </li> <li id="cite_note-pmid38627-5"><span class="mw-cite-backlink noprint"><a href="#cite_ref-pmid38627_5-0">↑</a> </span><span class="reference-text"><span class="ouvrage" id="R1979"><span class="ouvrage" id="Liljequist_R1979"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Liljequist R, « <cite style="font-style:normal" lang="en">Acute effects of temazepam and nitrazepam on psychomotor skills and memory</cite> », <i><span class="lang-en" lang="en">Acta Pharmacol Toxicol (Copenh)</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 44, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 5,‎ <time class="nowrap" datetime="1979-05" data-sort-value="1979-05">mai 1979</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">364–9</span> <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/38627">38627</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1111/j.1600-0773.1979.tb02346.x">10.1111/j.1600-0773.1979.tb02346.x</a></span>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Acute+effects+of+temazepam+and+nitrazepam+on+psychomotor+skills+and+memory&rft.jtitle=Acta+Pharmacol+Toxicol+%28Copenh%29&rft.issue=5&rft.aulast=R&rft.aufirst=Liljequist&rft.date=1979-05&rft.volume=44&rft.pages=364%E2%80%939&rft_id=info%3Adoi%2F10.1111%2Fj.1600-0773.1979.tb02346.x&rft_id=info%3Apmid%2F38627&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AT%C3%A9maz%C3%A9pam"></span></span></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink noprint"><a href="#cite_ref-6">↑</a> </span><span class="reference-text"><span class="ouvrage" id="A2004"><span class="ouvrage" id="Vermeeren_A2004"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Vermeeren A, « <cite style="font-style:normal" lang="en">Residual effects of hypnotics: epidemiology and clinical implications</cite> », <i><span class="lang-en" lang="en">CNS Drugs</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 18, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 5,‎ <time>2004</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">297–328</span> <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/15089115">15089115</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.2165/00023210-200418050-00003">10.2165/00023210-200418050-00003</a></span>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Residual+effects+of+hypnotics%3A+epidemiology+and+clinical+implications&rft.jtitle=CNS+Drugs&rft.issue=5&rft.aulast=A&rft.aufirst=Vermeeren&rft.date=2004&rft.volume=18&rft.pages=297%E2%80%93328&rft_id=info%3Adoi%2F10.2165%2F00023210-200418050-00003&rft_id=info%3Apmid%2F15089115&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AT%C3%A9maz%C3%A9pam"></span></span></span></span> </li> <li id="cite_note-pmid2891534-7"><span class="mw-cite-backlink noprint"><a href="#cite_ref-pmid2891534_7-0">↑</a> </span><span class="reference-text"><span class="ouvrage" id="FO,_Van_Dyk_M,_Hundt_HK,_et_al.1987"><span class="ouvrage" id="Müller_FO,_Van_Dyk_M,_Hundt_HK,_et_al.1987"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Müller FO, Van Dyk M, Hundt HK, <i>et al.</i>, « <cite style="font-style:normal" lang="en">Pharmacokinetics of temazepam after day-time and night-time oral administration</cite> », <i><span class="lang-en" lang="en">Eur. J. Clin. Pharmacol</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 33, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 2,‎ <time>1987</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">211–4</span> <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/2891534">2891534</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1007/BF00544571">10.1007/BF00544571</a></span>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pharmacokinetics+of+temazepam+after+day-time+and+night-time+oral+administration&rft.jtitle=Eur.+J.+Clin.+Pharmacol&rft.issue=2&rft.au=M%C3%BCller+FO%2C+Van+Dyk+M%2C+Hundt+HK%2C+%27%27et+al.%27%27&rft.date=1987&rft.volume=33&rft.pages=211%E2%80%934&rft_id=info%3Adoi%2F10.1007%2FBF00544571&rft_id=info%3Apmid%2F2891534&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AT%C3%A9maz%C3%A9pam"></span></span></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink noprint"><a href="#cite_ref-8">↑</a> </span><span class="reference-text"><span class="ouvrage" id="HJ1979"><span class="ouvrage" id="Schwarz_HJ1979"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Schwarz HJ, « <cite style="font-style:normal" lang="en">Pharmacokinetics and metabolism of temazepam in man and several animal species</cite> », <i><span class="lang-en" lang="en">British journal of clinical pharmacology</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 23, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 29,‎ <time class="nowrap" datetime="1979-08-01" data-sort-value="1979-08-01"><abbr class="abbr" title="premier">1<sup>er</sup></abbr> août 1979</time>, <abbr class="abbr" title="page(s)">p.</abbr> 23S–29S <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/41539">41539</a></span>, <a href="/wiki/PubMed_Central" title="PubMed Central">PMCID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/1429628">1429628</a></span>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pharmacokinetics+and+metabolism+of+temazepam+in+man+and+several+animal+species&rft.jtitle=British+journal+of+clinical+pharmacology&rft.issue=29&rft.aulast=HJ&rft.aufirst=Schwarz&rft.date=1979-08-01&rft.volume=23&rft.pages=23S%E2%80%9329S&rft_id=info%3Apmid%2F41539&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AT%C3%A9maz%C3%A9pam"></span></span></span></span> </li> </ol></div> <p><br /> </p> <ul><li><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Cet article est partiellement ou en totalité issu de l’article de Wikipédia en anglais intitulé <span class="plainlinks">« <a class="external text" href="https://en.wikipedia.org/wiki/Temazepam?oldid=413771922">Temazepam</a> » <small>(<a class="external text" href="https://en.wikipedia.org/wiki/Temazepam?action=history">voir la liste des auteurs</a>)</small></span>.</li></ul> <table class="navbox collapsible noprint autocollapse" style=""> <tbody><tr><th class="navbox-title" colspan="2" style=""><div style="float:left; width:6em; text-align:left"><div class="noprint plainlinks nowrap tnavbar" style="padding:0; font-size:xx-small; color:var(--color-emphasized, #000000);"><a href="/wiki/Mod%C3%A8le:Palette_S%C3%A9datif" title="Modèle:Palette Sédatif"><abbr class="abbr" title="Voir ce modèle.">v</abbr></a> · <a class="external text" href="https://fr.wikipedia.org/w/index.php?title=Mod%C3%A8le:Palette_S%C3%A9datif&action=edit"><abbr class="abbr" title="Modifier ce modèle. Merci de prévisualiser avant de sauvegarder.">m</abbr></a></div></div><div style="font-size:110%"><a href="/wiki/Psycholeptique" title="Psycholeptique">Psycholeptiques</a> : <a href="/wiki/Hypnotique" title="Hypnotique">hypnotiques</a> et <a href="/wiki/S%C3%A9datif" title="Sédatif">sédatifs</a> (<a href="/wiki/ATC_code_N05#N05C_Hypnotics_and_sedatives" class="mw-redirect" title="ATC code N05">N05C</a>)</div></th> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/R%C3%A9cepteurs_GABAA" class="mw-redirect" title="Récepteurs GABAA">Récepteurs GABA<sub>A</sub></a></th> <td class="navbox-list" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Barbiturique" title="Barbiturique">Barbiturique</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale">action ultra-courte : <ul><li><a href="/wiki/M%C3%A9thohexital" title="Méthohexital">Méthohexital</a></li> <li><a href="/wiki/Thiamylal" title="Thiamylal">Thiamylal</a></li> <li><a href="/wiki/Thiopental" title="Thiopental">Thiopental</a></li></ul> </div> <div class="liste-horizontale">action courte et intermédiaire : <ul><li><a href="/w/index.php?title=Allobarbital&action=edit&redlink=1" class="new" title="Allobarbital (page inexistante)">Allobarbital</a></li> <li><a href="/wiki/Amobarbital" title="Amobarbital">Amobarbital</a></li> <li><a href="/w/index.php?title=Butabarbital&action=edit&redlink=1" class="new" title="Butabarbital (page inexistante)">Butabarbital</a></li> <li><a href="/wiki/Butobarbital" title="Butobarbital">Butobarbital</a></li> <li><a href="/wiki/Pentobarbital" title="Pentobarbital">Pentobarbital</a></li> <li><a href="/wiki/S%C3%A9cobarbital" title="Sécobarbital">Sécobarbital</a></li> <li><a href="/w/index.php?title=Talbutal&action=edit&redlink=1" class="new" title="Talbutal (page inexistante)">Talbutal</a></li></ul> </div> <div class="liste-horizontale">action longue : <ul><li><a href="/wiki/Barbiturique" title="Barbiturique">Barbital</a></li> <li><a href="/w/index.php?title=M%C3%A9phobarbital&action=edit&redlink=1" class="new" title="Méphobarbital (page inexistante)">Méphobarbital</a></li> <li><a href="/wiki/Ph%C3%A9nobarbital" title="Phénobarbital">Phénobarbital</a></li></ul> </div> <div class="liste-horizontale">non regroupés : <ul><li><a href="/w/index.php?title=Cyclobarbital&action=edit&redlink=1" class="new" title="Cyclobarbital (page inexistante)">Cyclobarbital</a></li> <li><a href="/w/index.php?title=%C3%89thallobarbital&action=edit&redlink=1" class="new" title="Éthallobarbital (page inexistante)">Éthallobarbital</a></li> <li><a href="/w/index.php?title=Heptabarbital&action=edit&redlink=1" class="new" title="Heptabarbital (page inexistante)">Heptabarbital</a></li> <li><a href="/w/index.php?title=Hexobarbital&action=edit&redlink=1" class="new" title="Hexobarbital (page inexistante)">Hexobarbital</a></li> <li><a href="/w/index.php?title=Proxibarbal&action=edit&redlink=1" class="new" title="Proxibarbal (page inexistante)">Proxibarbal</a></li> <li><a href="/w/index.php?title=Reposal&action=edit&redlink=1" class="new" title="Reposal (page inexistante)">Reposal</a></li> <li><a href="/w/index.php?title=Vinylbital&action=edit&redlink=1" class="new" title="Vinylbital (page inexistante)">Vinylbital</a></li> <li><a href="/w/index.php?title=Vinbarbital&action=edit&redlink=1" class="new" title="Vinbarbital (page inexistante)">Vinbarbital</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Benzodiaz%C3%A9pine" title="Benzodiazépine">Benzodiazépines</a></th> <td class="navbox-list navbox-even" style="text-align:left;"><div class="liste-horizontale">action courte : <ul><li><a href="/wiki/Brotizolam" title="Brotizolam">Brotizolam</a></li> <li><a href="/wiki/Cinolaz%C3%A9pam" title="Cinolazépam">Cinolazépam</a></li> <li><a href="/w/index.php?title=Doxefaz%C3%A9pam&action=edit&redlink=1" class="new" title="Doxefazépam (page inexistante)">Doxefazépam</a></li> <li><a href="/wiki/Loprazolam" title="Loprazolam">Loprazolam</a></li> <li><a href="/wiki/Midazolam" title="Midazolam">Midazolam</a></li> <li><a href="/wiki/Triazolam" title="Triazolam">Triazolam</a></li></ul> </div> <div class="liste-horizontale">action intermédiaire : <ul><li><a href="/wiki/Estazolam" title="Estazolam">Estazolam</a></li> <li><a href="/wiki/Flunitraz%C3%A9pam" title="Flunitrazépam">Flunitrazépam</a></li> <li><a href="/wiki/Lorm%C3%A9taz%C3%A9pam" title="Lormétazépam">Lormétazépam</a></li> <li><a href="/w/index.php?title=Nimetaz%C3%A9pam&action=edit&redlink=1" class="new" title="Nimetazépam (page inexistante)">Nimetazépam</a></li> <li><a class="mw-selflink selflink">Témazépam</a></li></ul> </div> <div class="liste-horizontale">action longue : <ul><li><a href="/wiki/Fluraz%C3%A9pam" title="Flurazépam">Flurazépam</a></li> <li><a href="/w/index.php?title=Flutopraz%C3%A9pam&action=edit&redlink=1" class="new" title="Flutoprazépam (page inexistante)">Flutoprazépam</a></li> <li><a href="/wiki/Nitraz%C3%A9pam" title="Nitrazépam">Nitrazépam</a></li> <li><a href="/w/index.php?title=Quazepam&action=edit&redlink=1" class="new" title="Quazepam (page inexistante)">Quazepam</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon">Dialkylphénols</th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=Fospropofol&action=edit&redlink=1" class="new" title="Fospropofol (page inexistante)">Fospropofol</a></li> <li><a href="/wiki/Propofol" title="Propofol">Propofol</a></li> <li><a href="/wiki/Thymol" title="Thymol">Thymol</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon">Non-benzodiazépines</th> <td class="navbox-list navbox-even" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=CL-218,872&action=edit&redlink=1" class="new" title="CL-218,872 (page inexistante)">CL-218,872</a></li> <li><a href="/wiki/Eszopiclone" title="Eszopiclone">Eszopiclone</a></li> <li><a href="/w/index.php?title=Indiplon&action=edit&redlink=1" class="new" title="Indiplon (page inexistante)">Indiplon</a></li> <li><a href="/w/index.php?title=Lirequinil&action=edit&redlink=1" class="new" title="Lirequinil (page inexistante)">Lirequinil</a></li> <li><a href="/w/index.php?title=N%C3%A9copidem&action=edit&redlink=1" class="new" title="Nécopidem (page inexistante)">Nécopidem</a></li> <li><a href="/w/index.php?title=Pazinaclone&action=edit&redlink=1" class="new" title="Pazinaclone (page inexistante)">Pazinaclone</a></li> <li><a href="/w/index.php?title=ROD-188&action=edit&redlink=1" class="new" title="ROD-188 (page inexistante)">ROD-188</a></li> <li><a href="/w/index.php?title=Saripidem&action=edit&redlink=1" class="new" title="Saripidem (page inexistante)">Saripidem</a></li> <li><a href="/wiki/Suproclone" title="Suproclone">Suproclone</a></li> <li><a href="/w/index.php?title=Suriclone&action=edit&redlink=1" class="new" title="Suriclone (page inexistante)">Suriclone</a></li> <li><a href="/w/index.php?title=SX-3228&action=edit&redlink=1" class="new" title="SX-3228 (page inexistante)">SX-3228</a></li> <li><a href="/w/index.php?title=U-89843A&action=edit&redlink=1" class="new" title="U-89843A (page inexistante)">U-89843A</a></li> <li><a href="/w/index.php?title=U-90042&action=edit&redlink=1" class="new" title="U-90042 (page inexistante)">U-90042</a></li> <li><a href="/wiki/Zaleplon" title="Zaleplon">Zaleplon</a></li> <li><a href="/wiki/Zolpidem" title="Zolpidem">Zolpidem</a></li> <li><a href="/wiki/Zopiclone" title="Zopiclone">Zopiclone</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/w/index.php?title=Pip%C3%A9ridinedione&action=edit&redlink=1" class="new" title="Pipéridinedione (page inexistante)">Pipéridinediones</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=Glut%C3%A9thimide&action=edit&redlink=1" class="new" title="Glutéthimide (page inexistante)">Glutéthimide</a></li> <li><a href="/w/index.php?title=M%C3%A9thyprylon&action=edit&redlink=1" class="new" title="Méthyprylon (page inexistante)">Méthyprylon</a></li> <li><a href="/w/index.php?title=Pyrithyldione&action=edit&redlink=1" class="new" title="Pyrithyldione (page inexistante)">Pyrithyldione</a></li> <li><a href="/w/index.php?title=Pip%C3%A9ridione&action=edit&redlink=1" class="new" title="Pipéridione (page inexistante)">Pipéridione</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Quinazolinone" title="Quinazolinone">Quinazolinones</a></th> <td class="navbox-list navbox-even" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=Afloqualone&action=edit&redlink=1" class="new" title="Afloqualone (page inexistante)">Afloqualone</a></li> <li><a href="/w/index.php?title=Cloroqualone&action=edit&redlink=1" class="new" title="Cloroqualone (page inexistante)">Cloroqualone</a></li> <li><a href="/w/index.php?title=Diproqualone&action=edit&redlink=1" class="new" title="Diproqualone (page inexistante)">Diproqualone</a></li> <li><a href="/w/index.php?title=%C3%89taqualone&action=edit&redlink=1" class="new" title="Étaqualone (page inexistante)">Étaqualone</a></li> <li><a href="/w/index.php?title=M%C3%A9broqualone&action=edit&redlink=1" class="new" title="Mébroqualone (page inexistante)">Mébroqualone</a></li> <li><a href="/w/index.php?title=M%C3%A9cloqualone&action=edit&redlink=1" class="new" title="Mécloqualone (page inexistante)">Mécloqualone</a></li> <li><a href="/wiki/M%C3%A9thaqualone" title="Méthaqualone">Méthaqualone</a></li> <li><a href="/w/index.php?title=M%C3%A9thylmethaqualone&action=edit&redlink=1" class="new" title="Méthylmethaqualone (page inexistante)">Méthylmethaqualone</a></li> <li><a href="/w/index.php?title=Nitrom%C3%A9thaqualone&action=edit&redlink=1" class="new" title="Nitrométhaqualone (page inexistante)">Nitrométhaqualone</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/St%C3%A9ro%C3%AFde_neuroactif" title="Stéroïde neuroactif">Stéroïde neuroactif</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=Ac%C3%A9brochol&action=edit&redlink=1" class="new" title="Acébrochol (page inexistante)">Acébrochol</a></li> <li><a href="/wiki/Allopr%C3%A9gnanolone" title="Alloprégnanolone">Alloprégnanolone</a></li> <li><a href="/w/index.php?title=Alfadolone&action=edit&redlink=1" class="new" title="Alfadolone (page inexistante)">Alfadolone</a></li> <li><a href="/w/index.php?title=Alphaxolone&action=edit&redlink=1" class="new" title="Alphaxolone (page inexistante)">Alphaxolone</a></li> <li><a href="/w/index.php?title=Eltanolone&action=edit&redlink=1" class="new" title="Eltanolone (page inexistante)">Eltanolone</a></li> <li><a href="/wiki/Ganaxolone" title="Ganaxolone">Ganaxolone</a></li> <li><a href="/w/index.php?title=Hydroxydione&action=edit&redlink=1" class="new" title="Hydroxydione (page inexistante)">Hydroxydione</a></li> <li><a href="/w/index.php?title=Minaxolone&action=edit&redlink=1" class="new" title="Minaxolone (page inexistante)">Minaxolone</a></li> <li><a href="/w/index.php?title=Org_20599&action=edit&redlink=1" class="new" title="Org 20599 (page inexistante)">Org 20599</a></li> <li><a href="/w/index.php?title=Org_21465&action=edit&redlink=1" class="new" title="Org 21465 (page inexistante)">Org 21465</a></li> <li><a href="/w/index.php?title=T%C3%A9trahydrod%C3%A9oxycorticost%C3%A9rone&action=edit&redlink=1" class="new" title="Tétrahydrodéoxycorticostérone (page inexistante)">Tétrahydrodéoxycorticostérone</a></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/R%C3%A9cepteur_adr%C3%A9nergique#Récepteurs_Alpha-1" title="Récepteur adrénergique">Récepteurs adrénergiques alpha-2</a></th> <td class="navbox-list navbox-even" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/w/index.php?title=Agoniste_alpha-adr%C3%A9nergique&action=edit&redlink=1" class="new" title="Agoniste alpha-adrénergique (page inexistante)">Agoniste alpha-adrénergique</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=4-NEMD&action=edit&redlink=1" class="new" title="4-NEMD (page inexistante)">4-NEMD</a></li> <li><a href="/wiki/Clonidine" title="Clonidine">Clonidine</a></li> <li><a href="/wiki/Dexm%C3%A9d%C3%A9tomidine" title="Dexmédétomidine">Dexmédétomidine</a></li> <li><a href="/w/index.php?title=Lofexidine&action=edit&redlink=1" class="new" title="Lofexidine (page inexistante)">Lofexidine</a></li> <li><a href="/wiki/M%C3%A9d%C3%A9tomidine" title="Médétomidine">Médétomidine</a></li> <li><a href="/wiki/Romifidine" title="Romifidine">Romifidine</a></li> <li><a href="/wiki/Tizanidine" title="Tizanidine">Tizanidine</a></li> <li><a href="/wiki/Xylazine" title="Xylazine">Xylazine</a></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/M%C3%A9latonine" title="Mélatonine">Récepteur de mélatonine</a></th> <td class="navbox-list" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/M%C3%A9latonine" title="Mélatonine">Mélatonine</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/wiki/Agom%C3%A9latine" title="Agomélatine">Agomélatine</a></li> <li><a href="/wiki/M%C3%A9latonine" title="Mélatonine">Mélatonine</a></li> <li><a href="/wiki/Ramelt%C3%A9on" class="mw-redirect" title="Rameltéon">Rameltéon</a></li> <li><a href="/wiki/Tasimelt%C3%A9on" title="Tasimeltéon">Tasimeltéon</a></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Histamine" title="Histamine">Récepteur d'histamine</a> et <a href="/wiki/Ac%C3%A9tylcholine" title="Acétylcholine">récepteur d'acétylcholine</a></th> <td class="navbox-list navbox-even" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Antihistaminique" title="Antihistaminique">Antihistaminiques</a> et <a href="/wiki/Anticholinergique" title="Anticholinergique">anticholinergiques</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/wiki/Doxylamine" title="Doxylamine">Doxylamine</a></li> <li><a href="/wiki/Hydroxyzine" title="Hydroxyzine">Hydroxyzine</a></li> <li><a href="/wiki/Diph%C3%A9nhydramine" title="Diphénhydramine">Diphénhydramine</a></li> <li><a href="/w/index.php?title=Bromodiph%C3%A9nhydramine&action=edit&redlink=1" class="new" title="Bromodiphénhydramine (page inexistante)">Bromodiphénhydramine</a></li> <li><a href="/w/index.php?title=Carbinoxamine&action=edit&redlink=1" class="new" title="Carbinoxamine (page inexistante)">Carbinoxamine</a></li> <li><a href="/wiki/Orph%C3%A9nadrine" title="Orphénadrine">Orphénadrine</a></li> <li><a href="/wiki/Niaprazine" title="Niaprazine">Niaprazine</a></li> <li><a href="/w/index.php?title=Ph%C3%A9nyltoloxamine&action=edit&redlink=1" class="new" title="Phényltoloxamine (page inexistante)">Phényltoloxamine</a></li> <li><a href="/w/index.php?title=Propiomazine&action=edit&redlink=1" class="new" title="Propiomazine (page inexistante)">Propiomazine</a></li> <li><a href="/w/index.php?title=Pyrilamine&action=edit&redlink=1" class="new" title="Pyrilamine (page inexistante)">Pyrilamine</a></li> <li><a href="/wiki/Scopolamine" title="Scopolamine">Scopolamine</a></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/R%C3%A9cepteurs_GABAB" class="mw-redirect" title="Récepteurs GABAB">Récepteur GABA<sub>B</sub></a> et <a href="/wiki/Acide_gamma-hydroxybutyrique" title="Acide gamma-hydroxybutyrique">récepteurs GHB</a></th> <td class="navbox-list" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="background: LemonChiffon">Type <a href="/wiki/Acide_gamma-hydroxybutyrique" title="Acide gamma-hydroxybutyrique">GHB</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/wiki/1,4-butanediol" class="mw-redirect" title="1,4-butanediol">1,4-butanediol</a></li> <li><a href="/wiki/Acide_ac%C3%A9burique" title="Acide acéburique">Acide acéburique</a></li> <li><a href="/w/index.php?title=GABOB&action=edit&redlink=1" class="new" title="GABOB (page inexistante)">GABOB</a></li> <li><a href="/wiki/Acide_gamma-hydroxybutyrique" title="Acide gamma-hydroxybutyrique">GHB (Oxybate de sodium)</a></li> <li><a href="/wiki/Gamma-butyrolactone" class="mw-redirect" title="Gamma-butyrolactone">GBL</a></li> <li><a href="/wiki/Gamma-val%C3%A9rolactone" class="mw-redirect" title="Gamma-valérolactone">Gamma-valérolactone</a></li> <li><a href="/w/index.php?title=N-m%C3%A9thyl-GABA&action=edit&redlink=1" class="new" title="N-méthyl-GABA (page inexistante)">N-méthyl-GABA</a></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon">Autres récepteurs</th> <td class="navbox-list navbox-even" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Ald%C3%A9hyde" title="Aldéhyde">Aldéhydes</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=Hydrate_d%27ac%C3%A9tylglycinamide_chloral&action=edit&redlink=1" class="new" title="Hydrate d'acétylglycinamide chloral (page inexistante)">Hydrate d'acétylglycinamide chloral</a></li> <li><a href="/wiki/Hydrate_de_chloral" title="Hydrate de chloral">Hydrate de chloral</a></li> <li><a href="/w/index.php?title=Chloralodol&action=edit&redlink=1" class="new" title="Chloralodol (page inexistante)">Chloralodol</a></li> <li><a href="/w/index.php?title=Dichloralph%C3%A9nazone&action=edit&redlink=1" class="new" title="Dichloralphénazone (page inexistante)">Dichloralphénazone</a></li> <li><a href="/wiki/Parald%C3%A9hyde" title="Paraldéhyde">Paraldéhyde</a></li> <li><a href="/w/index.php?title=P%C3%A9trichloral&action=edit&redlink=1" class="new" title="Pétrichloral (page inexistante)">Pétrichloral</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Alcyne" title="Alcyne">Alcynes</a></th> <td class="navbox-list navbox-even" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=Centalun&action=edit&redlink=1" class="new" title="Centalun (page inexistante)">Centalun</a></li> <li><a href="/w/index.php?title=Ethchlorvynol&action=edit&redlink=1" class="new" title="Ethchlorvynol (page inexistante)">Ethchlorvynol</a></li> <li><a href="/w/index.php?title=%C3%89thinamate&action=edit&redlink=1" class="new" title="Éthinamate (page inexistante)">Éthinamate</a></li> <li><a href="/w/index.php?title=Hexapropymate&action=edit&redlink=1" class="new" title="Hexapropymate (page inexistante)">Hexapropymate</a></li> <li><a href="/w/index.php?title=M%C3%A9thylpentynol&action=edit&redlink=1" class="new" title="Méthylpentynol (page inexistante)">Méthylpentynol</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon"><a href="/wiki/Carbamate" title="Carbamate">Carbamates</a></th> <td class="navbox-list" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/wiki/M%C3%A9probamate" title="Méprobamate">Méprobamate</a></li> <li><a href="/wiki/Carisoprodol" title="Carisoprodol">Carisoprodol</a></li> <li><a href="/w/index.php?title=Tybamate&action=edit&redlink=1" class="new" title="Tybamate (page inexistante)">Tybamate</a></li> <li><a href="/wiki/M%C3%A9thocarbamol" title="Méthocarbamol">Méthocarbamol</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="background: LemonChiffon">Autre</th> <td class="navbox-list navbox-even" style="text-align:left;"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=2-m%C3%A9thyl-2-butanol&action=edit&redlink=1" class="new" title="2-méthyl-2-butanol (page inexistante)">2-méthyl-2-butanol</a></li> <li><a href="/w/index.php?title=Ac%C3%A9carbromal&action=edit&redlink=1" class="new" title="Acécarbromal (page inexistante)">Acécarbromal</a></li> <li><a href="/wiki/Apronal" title="Apronal">Apronal</a></li> <li><a href="/wiki/Bromure" title="Bromure">Bromures</a></li> <li><a href="/wiki/Bromisoval" title="Bromisoval">Bromisoval</a></li> <li><a href="/w/index.php?title=Carbromal&action=edit&redlink=1" class="new" title="Carbromal (page inexistante)">Carbromal</a></li> <li><a href="/wiki/Chloralose" title="Chloralose">Chloralose</a></li> <li><a href="/wiki/Clom%C3%A9thiazole" title="Clométhiazole">Clométhiazole</a></li> <li><a href="/wiki/Embutramide" title="Embutramide">Embutramide</a></li> <li><a href="/wiki/%C3%89tomidate" title="Étomidate">Étomidate</a></li> <li><a href="/wiki/%C3%89voxine" title="Évoxine">Évoxine</a></li> <li><a href="/w/index.php?title=Gaboxadol&action=edit&redlink=1" class="new" title="Gaboxadol (page inexistante)">Gaboxadol</a></li> <li><a href="/w/index.php?title=Lor%C3%A9cl%C3%A9zole&action=edit&redlink=1" class="new" title="Loréclézole (page inexistante)">Loréclézole</a></li> <li><a href="/w/index.php?title=Mephenoxalone&action=edit&redlink=1" class="new" title="Mephenoxalone (page inexistante)">Mephenoxalone</a></li> <li><a href="/w/index.php?title=Sulfonem%C3%A9thane&action=edit&redlink=1" class="new" title="Sulfoneméthane (page inexistante)">Sulfoneméthane</a></li> <li><a href="/w/index.php?title=2,2,2-trichloro%C3%A9thanol&action=edit&redlink=1" class="new" title="2,2,2-trichloroéthanol (page inexistante)">Trichloroéthanol</a></li> <li><a href="/wiki/Triclofos" title="Triclofos">Triclofos</a></li> <li><a href="/wiki/Val%C3%A9riane" title="Valériane">Valériane</a></li> <li><a href="/wiki/Valnoctamide" title="Valnoctamide">Valnoctamide</a></li> <li><a href="/wiki/Trazodone" title="Trazodone">Trazodone</a></li></ul> </div></td> </tr> </tbody></table></td> </tr> </tbody></table> <ul id="bandeau-portail" class="bandeau-portail"><li><span class="bandeau-portail-element"><span class="bandeau-portail-icone"><span class="noviewer" typeof="mw:File"><a href="/wiki/Portail:Chimie" title="Portail de la chimie"><img alt="icône décorative" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/Nuvola_apps_edu_science.svg/24px-Nuvola_apps_edu_science.svg.png" decoding="async" width="24" height="24" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/Nuvola_apps_edu_science.svg/36px-Nuvola_apps_edu_science.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/59/Nuvola_apps_edu_science.svg/48px-Nuvola_apps_edu_science.svg.png 2x" data-file-width="128" data-file-height="128" /></a></span></span> <span class="bandeau-portail-texte"><a href="/wiki/Portail:Chimie" title="Portail:Chimie">Portail de la chimie</a></span> </span></li> <li><span class="bandeau-portail-element"><span class="bandeau-portail-icone"><span class="noviewer" typeof="mw:File"><a href="/wiki/Portail:Pharmacie" title="Portail de la pharmacie"><img alt="icône décorative" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1a/Coupe_d%27Hygie.svg/20px-Coupe_d%27Hygie.svg.png" decoding="async" width="20" height="24" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1a/Coupe_d%27Hygie.svg/30px-Coupe_d%27Hygie.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1a/Coupe_d%27Hygie.svg/40px-Coupe_d%27Hygie.svg.png 2x" data-file-width="354" data-file-height="427" /></a></span></span> <span class="bandeau-portail-texte"><a href="/wiki/Portail:Pharmacie" title="Portail:Pharmacie">Portail de la pharmacie</a></span> </span></li> <li><span class="bandeau-portail-element"><span class="bandeau-portail-icone"><span class="noviewer skin-invert-image" typeof="mw:File"><a href="/wiki/Portail:Sommeil_et_R%C3%AAve" 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