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text-[16px] underline"><span>View All</span></a></div><div style="scroll-snap-type:none" class="jsx-19ede9f0a5a45918 flex items-start overflow-x-auto space-x-4 py-4 relative mx-auto w-[calc(100%-64px)]"><a target="" style="scroll-snap-align:center;text-decoration:none" class="jsx-1215160397 sm:w-[280px] xs:w-[240px] w-[65%] h-auto flex flex-col space-y-3 flex-none select-none no-underline" href="/view/insufficient-data-disparities-plague-lung-cancer-risk-factor-documentation"><div class="jsx-1215160397 w-full h-full flex flex-col overflow-hidden relative bg-white text-center"><div class="jsx-1215160397 relative w-full shadow-md shadow-grey-800 aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" 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style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-cover" loading="lazy"/></noscript></span></div><div class="jsx-1215160397 content-wrap"><span class="jsx-1215160397 py-3 text-sm text-gray-500 text-left"><i class="jsx-1215160397">September 24th 2023</i></span><div class="jsx-1215160397 w-full h-fit mb-4"><p class="jsx-1215160397 text-[18px] font-bold text-[#000000] text-left line-clamp-3 text-hidden">Insufficient Data, Disparities Plague Lung Cancer Risk Factor Documentation </p></div></div></div></a></div></div></div><div class="flex items-center space-x-4 border-0 border-b border-secondary select-none py-1"><h2 class="text-3xl text-primary">More News</h2></div><div class="flex flex-wrap w-full pb-4"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/tarlatamab-receives-accelerated-approval-for-extensive-stage-sclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/db6c88afb196508d8ce41e2f72273ee54168e353-6000x4000.jpg?fit=crop&auto=format" alt="Doctor with health care icons and FDA | Image credit: wladimir1804 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 17th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/tarlatamab-receives-accelerated-approval-for-extensive-stage-sclc">Tarlatamab Receives Accelerated Approval for Extensive-Stage SCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/tarlatamab-receives-accelerated-approval-for-extensive-stage-sclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA has approved tarlatamab (Imdelltra; Amgen), a novel bispecific T-cell engager, to treat patients with extensive-stage small cell lung cancer (SCLC).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/top-5-most-read-lung-cancer-articles-of-2023"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/796347f961045d4dadcbd28a768a698101c153bc-3187x1625.png?fit=crop&auto=format" alt="Top 5 Most-Read Lung Cancer Articles of 2023" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 25th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/top-5-most-read-lung-cancer-articles-of-2023">Top 5 Most-Read Lung Cancer Articles of 2023</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/julia-bonavitacola">Julia Bonavitacola</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/top-5-most-read-lung-cancer-articles-of-2023"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Our most-read content that featured lung cancer included articles on non–small cell lung cancer, how navigation programs can increase screening rates, and a potential link between antidepressants and lung cancer risk.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/tarlatamab-application-for-sclc-granted-priority-review-by-fda"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e6fc92fc0236504a1b3f0c2a303f176b0b279d1c-4500x3000.jpg?fit=crop&auto=format" alt="Lung cancer | Image credit: Dr_Microbe - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 14th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/tarlatamab-application-for-sclc-granted-priority-review-by-fda">Tarlatamab Application for SCLC Granted Priority Review by FDA</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/julia-bonavitacola">Julia Bonavitacola</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/tarlatamab-application-for-sclc-granted-priority-review-by-fda"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The treatment developed by Amgen could be the first therapeutic option approved for third-line treatment of advanced small cell lung cancer (SCLC).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/aerobic-exercise-tai-chi-improved-sleep-in-patients-with-lung-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/62d2a3b079833eb4f32e8ce1d93cdb76ccd8c9b5-4928x3264.jpg?fit=crop&auto=format" alt="Tai chi chuan | Image credit: Markgraf Ave - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 13th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/aerobic-exercise-tai-chi-improved-sleep-in-patients-with-lung-cancer">Aerobic Exercise, Tai Chi Improved Sleep in Patients With Lung Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/julia-bonavitacola">Julia Bonavitacola</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/aerobic-exercise-tai-chi-improved-sleep-in-patients-with-lung-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Improved psychological distress and physical function were among the benefits of doing aerobic exercise and tai chi as a patient with lung cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/prediction-model-identified-risk-factors-for-ed-visits-in-patients-with-lung-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a502d33f191e80c9212d9abe8be1ccb8d782e058-5616x3744.jpg?fit=crop&auto=format" alt="Prediction Model Identified Risk Factors for ED Visits in Patients With Lung Cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 7th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/prediction-model-identified-risk-factors-for-ed-visits-in-patients-with-lung-cancer">Prediction Model Identified Risk Factors for ED Visits in Patients With Lung Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/julia-bonavitacola">Julia Bonavitacola</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/prediction-model-identified-risk-factors-for-ed-visits-in-patients-with-lung-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A risk prediction model that was based on machine learning could help to make resource utilization more efficient by correctly predicting emergency department (ED) visits in patients with lung cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/early-ct-screening-significantly-improves-survival-in-lung-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9f975ae9c2ee542c6552c8d164ca16788f849a8b-5000x3750.jpg?fit=crop&auto=format" alt="Lung cancer illustration | Image credit: SciePro - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 28th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/early-ct-screening-significantly-improves-survival-in-lung-cancer">Early CT Screening Significantly Improves Survival in Lung Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rina-lokaj">Rina Lokaj</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/early-ct-screening-significantly-improves-survival-in-lung-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Early CT screening leads to a 20-year lung cancer survival rate of 81%. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-7"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/trilaciclib-may-reduce-hospitalization-and-improve-survival-in-es-sclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/66c1591b2bef5d67825d9c88b2fdb7bf9429f3d2-4577x2647.jpg?fit=crop&auto=format" alt="Hospital corridor | Image credit: VILevi - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 23rd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/trilaciclib-may-reduce-hospitalization-and-improve-survival-in-es-sclc">Trilaciclib May Reduce Hospitalization and Improve Survival in ES-SCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/russ-conroy">Russ Conroy</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/trilaciclib-may-reduce-hospitalization-and-improve-survival-in-es-sclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with extensive-stage small cell lung cancer (ES-SCLC) who receive trilaciclib appear to experience lower rates of hematologic adverse effects than those who are not treated with the agent.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-medicaid-coverage-errors-gender-disparities-in-health-research-improved-lung-cancer-survival-rates"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/703de894e882d8a6da8c19964dc1ca71b969d30c-2000x1046.png?fit=crop&auto=format" alt="What We’re Reading: Medicaid Coverage Errors; Gender Disparities in Health Research; Improved Lung Cancer Survival Rates" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 14th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-medicaid-coverage-errors-gender-disparities-in-health-research-improved-lung-cancer-survival-rates">What We’re Reading: Medicaid Coverage Errors; Gender Disparities in Health Research; Improved Lung Cancer Survival Rates</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-staff">AJMC Staff</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-medicaid-coverage-errors-gender-disparities-in-health-research-improved-lung-cancer-survival-rates"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Up to 30 million individuals could lose Medicaid coverage; a new initiative demands increased focus on women's health issues; survey reports increased 5-year lung cancer survival rates from 2015 to 2019.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-expanded-lung-cancer-screening-guidelines-expert-health-insurance-advice-patients-uber-to-appointments"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/703de894e882d8a6da8c19964dc1ca71b969d30c-2000x1046.png?fit=crop&auto=format" alt="what we're reading logo" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 2nd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-expanded-lung-cancer-screening-guidelines-expert-health-insurance-advice-patients-uber-to-appointments">What We’re Reading: Expanded Lung Cancer Screening Guidelines; Expert Health Insurance Advice; Patients Uber to Appointments</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-staff">AJMC Staff</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-expanded-lung-cancer-screening-guidelines-expert-health-insurance-advice-patients-uber-to-appointments"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The American Cancer Society expanded eligibility for lung cancer screening; experts advised patients to do their research before choosing a plan from the Affordable Care Act’s insurance marketplaces; Republican-led states partnering with rideshare companies for medical appointment rides.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/osimertinib-combo-lessens-cns-progression-in-egfr-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a56acbbdc6570b29acf1ac2ed733b60a00685cf2-3840x2160.jpg?fit=crop&auto=format" alt="Lung cancer cells | Image credit: David A Litman - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 1st 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/osimertinib-combo-lessens-cns-progression-in-egfr-nsclc">Osimertinib Combo Lessens CNS Progression in EGFR NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/darlene-dobkowski-ma">Darlene Dobkowski, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/osimertinib-combo-lessens-cns-progression-in-egfr-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Central nervous system (CNS) progression was reduced with osimertinib plus chemotherapy for patients with EGFR-mutated non-small cell lung cancer plus CNS metastases.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/adding-adjuvant-nivolumab-builds-on-standard-of-care-for-resectable-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/33930ac2392d0877877bbbad5a8e2c170f33858d-1200x800.jpg?fit=crop&auto=format" alt="design of lungs with green, blue, and yellow colors" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 22nd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/adding-adjuvant-nivolumab-builds-on-standard-of-care-for-resectable-nsclc">Adding Adjuvant Nivolumab Builds on Standard of Care for Resectable NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/adding-adjuvant-nivolumab-builds-on-standard-of-care-for-resectable-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The results of CheckMate 77T showcase the improved event-free survival for patients with resectable non–small cell lung cancer who receive nivolumab in both the neoadjuvant and adjuvant setting and may have practice-changing implications. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-grants-pembrolizumab-sixth-indication-in-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/bf365d9c6f891c03e1fc1d99398a075dea15607e-3508x2480.jpg?fit=crop&auto=format" alt="Red FDA Approved stamp on a white backgroun" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 17th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-grants-pembrolizumab-sixth-indication-in-nsclc">FDA Grants Pembrolizumab Sixth Indication in NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-grants-pembrolizumab-sixth-indication-in-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The anti–PD-1 agent pembrolizumab was granted a new indication to treat patients with resectable non–small cell lung cancer (NSCLC) as a neoadjuvant treatment with chemotherapy and continued as adjuvant treatment after surgery.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-13"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-school-nurse-shortage-keytruda-receives-fda-expansion-menthol-cigarette-flavored-cigar-ban"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/703de894e882d8a6da8c19964dc1ca71b969d30c-2000x1046.png?fit=crop&auto=format" alt="What We’re Reading: School Nurse Shortage; Keytruda Receives FDA Expansion; Menthol Cigarette, Flavored Cigar Ban" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 17th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-school-nurse-shortage-keytruda-receives-fda-expansion-menthol-cigarette-flavored-cigar-ban">What We’re Reading: School Nurse Shortage; Keytruda Receives FDA Expansion; Menthol Cigarette, Flavored Cigar Ban</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-staff">AJMC Staff</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-school-nurse-shortage-keytruda-receives-fda-expansion-menthol-cigarette-flavored-cigar-ban"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">School nurses play an overworked and understaffed role; Merck's immunotherapy Keytruda (pembroilzumab) has been granted approval for pre- and postsurgical treatment in lung cancer; the FDA is helping to curb tobacco-related health disparities.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/patients-with-distant-recurrent-nsclc-had-better-os-vs-those-with-de-novo-disease"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9f975ae9c2ee542c6552c8d164ca16788f849a8b-5000x3750.jpg?fit=crop&auto=format" alt="3rd rendered medically accurate illustration of lung cancer Stock Illustration | © Adobe Stock" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 11th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-distant-recurrent-nsclc-had-better-os-vs-those-with-de-novo-disease">Patients With Distant Recurrent NSCLC Had Better OS vs Those With De Novo Disease</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/justina-petrullo">Justina Petrullo</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-distant-recurrent-nsclc-had-better-os-vs-those-with-de-novo-disease"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with distant recurrent non–small cell lung cancer (NSCLC) had significantly better overall survival (OS) than patients who had de novo disease.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/takeda-to-voluntarily-withdraw-mobocertinib-for-egfr-exon-20-insertion-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/442fb3ee31b1218b821b8ba9b713726bae66abf5-1280x737.jpg?fit=crop&auto=format" alt="Hands holding a paper set of lungs | Image credit: SewcreamStudio - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 4th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/takeda-to-voluntarily-withdraw-mobocertinib-for-egfr-exon-20-insertion-nsclc">Takeda to Voluntarily Withdraw Mobocertinib for EGFR Exon 20 Insertion+ NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kristi-rosa">Kristi Rosa</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/takeda-to-voluntarily-withdraw-mobocertinib-for-egfr-exon-20-insertion-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Following discussions with FDA, Takeda will voluntarily withdraw mobocertinib in the United States for adult patients with EGFR exon 20 insertion mutation–positive, locally advanced or metastatic non–small cell lung cancer (NSCLC) based on the outcomes of the phase 3 EXCLAIM-2 trial.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/adjuvant-therapy-for-early-stage-nsclc-after-surgery-yields-lower-costs"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f2470519bf4a5d739e4ffd6e213ea4c8833a15f8-1698x1131.jpg?fit=crop&auto=format" alt="Health Care Costs Stock Photos and Images - 123RF | © 123RF Stock Photos" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 26th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/adjuvant-therapy-for-early-stage-nsclc-after-surgery-yields-lower-costs">Adjuvant Therapy for Early-Stage NSCLC After Surgery Yields Lower Costs</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/justina-petrullo">Justina Petrullo</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/adjuvant-therapy-for-early-stage-nsclc-after-surgery-yields-lower-costs"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Adjuvant therapy, instead of just surgery alone, for early-stage non-small-cell lung cancer (NSCLC) after surgery incurs lower medical costs than surgery alone.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/hr-nsclc-more-common-in-women-egfr-kras-more-common-in-hr-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/79e063bbbcb49d153f1213e63312b1ab97912027-1200x900.jpg?fit=crop&auto=format" alt="DNA double helix molecules and chromosomes | © Adobe Stock" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 18th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/hr-nsclc-more-common-in-women-egfr-kras-more-common-in-hr-nsclc">HR+ NSCLC More Common in Women; EGFR, KRAS More Common in HR+ NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/justina-petrullo">Justina Petrullo</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/hr-nsclc-more-common-in-women-egfr-kras-more-common-in-hr-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Women have a higher likelihood of having hormone receptor (HR+) non-small cell lung cancer (NSCLC) than men, and mutations of EGFR and KRAS were more common in HR+ NSCLC in a recent study.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/osimertinib-plus-chemotherapy-demonstrated-greater-pfs-benefit-in-patients-with-egfrm-advanced-nsclc-than-osimertinib-alone"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/36c9cc760549a177d5e20e8ce07f6a18ef239a6d-500x700.jpg?fit=crop&auto=format" alt="Dr. Pasi A. Jänne from the Lowe Center for Thoracic Oncology at Dana-Farber Cancer Institute in Boston, Mass." width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 12th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/osimertinib-plus-chemotherapy-demonstrated-greater-pfs-benefit-in-patients-with-egfrm-advanced-nsclc-than-osimertinib-alone">Osimertinib Plus Chemotherapy Demonstrated Greater PFS Benefit in Patients With EGFRm Advanced NSCLC Than Osimertinib Alone</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/justina-petrullo">Justina Petrullo</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/osimertinib-plus-chemotherapy-demonstrated-greater-pfs-benefit-in-patients-with-egfrm-advanced-nsclc-than-osimertinib-alone"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Osimertinib administered in addition to chemotherapy showed more progression-free survival (PFS) benefit than just osimertinib in patients with epidermal growth factor receptor–mutated (EGFRm) advanced non–small cell lung cancer (NSCLC).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-19"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/patients-with-nsclc-describe-experiences-of-symptoms-on-daily-life"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ea88dc7bff8216eb6f09503aa8387c0e4d55cd66-2048x1365.jpg?fit=crop&auto=format" alt="Woman Suffering an Anxiety Attack Alone in the Night Stock Photo | Image Credit iStockPhoto.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 12th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-nsclc-describe-experiences-of-symptoms-on-daily-life">Patients With NSCLC Describe Experiences of Symptoms on Daily Life</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/justina-petrullo">Justina Petrullo</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-nsclc-describe-experiences-of-symptoms-on-daily-life"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with advanced or metastatic non–small cell lung cancer (NSCLC) were able to specify a 1-point threshold when describing meaningful symptom change, for better or worse, that helped illustrate their symptom experience.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/liquid-biopsy-might-be-useful-in-the-detection-of-colorectal-lung-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f1a9a005ba5be94ca7591ebb63388cb164411129-800x400.jpg?fit=crop&auto=format" alt="A graphic of a pair of lungs" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 6th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/liquid-biopsy-might-be-useful-in-the-detection-of-colorectal-lung-cancer">Liquid Biopsy Might Be Useful in the Detection of Colorectal, Lung Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/justina-petrullo">Justina Petrullo</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/liquid-biopsy-might-be-useful-in-the-detection-of-colorectal-lung-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Investigators wanted to analyze the diagnostic performance of methylation-sensitive restriction enzyme digestion followed by sequencing using cell-free DNA and explore the cancer signal origin of the cancer using DNN analyses for colorectal and lung cancers. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/elimination-of-pfts-might-worsen-disparities-for-african-american-patients-with-lung-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/aa4f637fea2cecc69666e40abde1bd8704484ef7-1280x853.jpg?fit=crop&auto=format" alt="A Black couple listens to a health care provider" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 3rd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/elimination-of-pfts-might-worsen-disparities-for-african-american-patients-with-lung-cancer">Elimination of PFTs Might Worsen Disparities for African American Patients With Lung Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/justina-petrullo">Justina Petrullo</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/elimination-of-pfts-might-worsen-disparities-for-african-american-patients-with-lung-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Removal of pulmonary function tests (PFTs) might exacerbate disparities for African American patients with lung cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/certain-immune-cell-types-linked-with-ici-response-in-patients-with-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6efb64967c6fc91328f776ac70d0d8b22b948a42-1000x600.jpg?fit=crop&auto=format" alt="A scientist is adding blood to vials" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 22nd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/certain-immune-cell-types-linked-with-ici-response-in-patients-with-nsclc">Certain Immune Cell Types Linked With ICI Response in Patients With NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/justina-petrullo">Justina Petrullo</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/certain-immune-cell-types-linked-with-ici-response-in-patients-with-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Certain immune cell types are associated with immune checkpoint inhibitor (ICI) response in patients with non–small cell lung cancer (NSCLC).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/perspectives-on-immunotherapy-in-the-treatment-of-advanced-nsclc-a-stakeholder-interchange-report"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/68f6092da49846c69f5cd86e58c93c2de4678fca-3840x2160.jpg?fit=crop&auto=format" alt="skeleton with lungs highlighted" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 21st 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/perspectives-on-immunotherapy-in-the-treatment-of-advanced-nsclc-a-stakeholder-interchange-report">Perspectives on Immunotherapy in the Treatment of Advanced NSCLC: A Stakeholder Interchange Report</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/perspectives-on-immunotherapy-in-the-treatment-of-advanced-nsclc-a-stakeholder-interchange-report"></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/machine-learning-models-may-help-determine-brain-metastasis-risk-in-patients-with-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/5680d327039592c8cb50c440eacb897f171ba52c-1200x801.jpg?fit=crop&auto=format" alt="graphic of a brain" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 19th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/machine-learning-models-may-help-determine-brain-metastasis-risk-in-patients-with-nsclc">Machine-Learning Models May Help Determine Brain Metastasis Risk in Patients With NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/justina-petrullo">Justina Petrullo</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/machine-learning-models-may-help-determine-brain-metastasis-risk-in-patients-with-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with non-small cell lung cancer (NSCLC) with a high risk of brain metastases might feasibly be identified through machine-learning models, according to a recent study.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-25"></div></div></div><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/phase-3-study-of-selpercatinib-meets-primary-pfs-end-point-in-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4c89f36d8308b7d7dc3e2e9d6f651079c20fa008-1200x800.jpg?fit=crop&auto=format" alt="graphic image of a human body showing lungs with cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 17th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/phase-3-study-of-selpercatinib-meets-primary-pfs-end-point-in-nsclc">Phase 3 Study of Selpercatinib Meets Primary PFS End Point in NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jordyn-sava">Jordyn Sava</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/phase-3-study-of-selpercatinib-meets-primary-pfs-end-point-in-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with RET fusion-positive advanced or metastatic non–small cell lung cancer had a survival benefit when treated with selpercatinib in the LIBRETTO-431 study.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/the-process-from-referral-to-lcs-is-a-crucial-point-among-veterans"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/518ddd47ca422abd4fb3a4b9be5d9dbc43fdecc1-300x300.jpg?fit=crop&auto=format" alt="United States flag patch on army clothing" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 7th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/the-process-from-referral-to-lcs-is-a-crucial-point-among-veterans">The Process From Referral to LCS Is a Crucial Point Among Veterans</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/justina-petrullo">Justina Petrullo</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/the-process-from-referral-to-lcs-is-a-crucial-point-among-veterans"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The process from referral to the lung cancer screening (LCS) process is a crucial point for Black veterans and may serve as a point of improvement, according to a study.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/changes-to-the-sclc-treatment-landscape-stirs-up-hope-for-oncologists"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/5d9997f64a640386cddb92f735b96fba5dfb07d9-820x820.png?fit=crop&auto=format" alt="Sagun Shrestha, MD" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 6th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/changes-to-the-sclc-treatment-landscape-stirs-up-hope-for-oncologists">Changes to the SCLC Treatment Landscape Stirs Up Hope for Oncologists</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jordyn-sava">Jordyn Sava</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/changes-to-the-sclc-treatment-landscape-stirs-up-hope-for-oncologists"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In an interview with Targeted Oncology, Sagun Shrestha, MD, evaluated new developments and clinical trials for patients with extensive-stage small cell lung cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/emory-s-ticiana-leal-md-says-rise-in-druggable-targets-boosts-importance-of-biomarker-testing-in-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/44efcc86764be66023a8fcc30795c8d6e1ba2682-213x184.webp?fit=crop&auto=format" alt="IVBM Logo" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 4th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/emory-s-ticiana-leal-md-says-rise-in-druggable-targets-boosts-importance-of-biomarker-testing-in-nsclc">Emory’s Ticiana Leal, MD, Says Rise in Druggable Targets Boosts Importance of Biomarker Testing in NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/emory-s-ticiana-leal-md-says-rise-in-druggable-targets-boosts-importance-of-biomarker-testing-in-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Coverage from the Institute for Value-Based Medicine event in Atlanta, held in partnership with Winship Cancer Institute of Emory University. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/wildfire-smoke-linked-to-worse-survival-for-individuals-with-nsclc-after-surgical-resection"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6bf1c1b01eb992fcd9e8342de09851a03d7a604b-800x534.jpg?fit=crop&auto=format" alt="a wildfire in a forest" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 2nd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/wildfire-smoke-linked-to-worse-survival-for-individuals-with-nsclc-after-surgical-resection">Wildfire Smoke Linked to Worse Survival for Individuals With NSCLC After Surgical Resection</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/justina-petrullo">Justina Petrullo</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/wildfire-smoke-linked-to-worse-survival-for-individuals-with-nsclc-after-surgical-resection"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Wildfire smoke is associated with worse survival for individuals with non–small cell lung cancer (NSCLC) who are recovering from surgical resection treatment.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/subtle-differences-in-nsclc-could-help-guide-treatment-strategies"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/396a9af855fe3590dc9fb5f6535db072c1b09e20-1280x800.jpg?fit=crop&auto=format" alt="radiology x-ray lung cancer: © utah51 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 31st 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/subtle-differences-in-nsclc-could-help-guide-treatment-strategies">Subtle Differences in NSCLC Could Help Guide Treatment Strategies </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/gwen-mergian">Gwen Mergian</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/subtle-differences-in-nsclc-could-help-guide-treatment-strategies"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Analysis suggests tumor histology plays an important role in determining the best first-line approach for patients who have non–small cell lung cancer (NSCLC). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div><div class="w-full text-center flex justify-center pb-24"><a class="px-4 py-2 border-y border-r bg-primary text-white" href="/compendium/lung-cancer?page=1">1</a><a class="px-4 py-2 border-y border-r " href="/compendium/lung-cancer?page=2">2</a><a class="px-4 py-2 border-y border-r " href="/compendium/lung-cancer?page=3">3</a><a class="px-4 py-2 border-y border-r " href="/compendium/lung-cancer?page=4">4</a><a class="px-4 py-2 border-y border-r " href="/compendium/lung-cancer?page=5">5</a><a class="px-4 py-2 border-y border-r " href="/compendium/lung-cancer?page=6">6</a><a class="px-4 py-2 border-y border-r " href="/compendium/lung-cancer?page=7">7</a><a class="px-4 py-2 border-y border-r " href="/compendium/lung-cancer?page=8">8</a><div class="px-4 py-2 border-y border-r">...</div><a class="px-4 py-2 border-y border-r" href="/compendium/lung-cancer?page=9">9</a><a class="px-4 py-2 border-y border-r" href="/compendium/lung-cancer?page=2">></a></div></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" 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Socinski, MD, executive director at AdventHealth Cancer Institute, discussed the emergence of targeted therapies for ","_key":"1401b1f686d60"},{"_key":"5dfc82f2432c","_type":"span","marks":["50dc1a0c305d"],"text":"lung cancer"},{"_type":"span","marks":[],"text":" and their ongoing impact on outcomes for certain patients. Socinski also discussed immune-mediated adverse events seen with immunotherapy and why they may indicate benefits for patients when mild to moderate in nature. ","_key":"bfb83ddd3517"}],"_type":"block","style":"normal","_key":"190e8b481743"},{"_key":"8863d811195f","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"d52b963f4e33"}],"_type":"block","style":"normal"},{"style":"normal","_key":"a026d7462eba","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Can you discuss the emergence of targeted therapies for lung cancer and their indications?","_key":"399aa9c5cbd80"}],"_type":"block"},{"_type":"block","style":"normal","_key":"5c6f96c253e0","markDefs":[],"children":[{"_type":"span","marks":[],"text":"So in 2024, next year, we will be celebrating the 20-year anniversary of the discovery of","_key":"ef68fef36e9f0"},{"_type":"span","marks":["em"],"text":" EGFR ","_key":"89aafcb41242"},{"_type":"span","marks":[],"text":"mutations in non–small cell lung cancer, and this set off a chain of a number of observations looking at specific DNA alterations. In 2007, ","_key":"3fe7dd1fb838"},{"marks":["em"],"text":"ALK","_key":"ca07de4708d3","_type":"span"},{"_type":"span","marks":[],"text":" fusions were described; in 2011, ","_key":"c2d2d7a8b436"},{"_type":"span","marks":["em"],"text":"ROS1","_key":"29da19602b36"},{"text":" fusions; shortly thereafter, ","_key":"45cb21aed40c","_type":"span","marks":[]},{"_type":"span","marks":["em"],"text":"BRAF","_key":"f0e4e48ca508"},{"text":"; shortly thereafter met exon 14 skip mutations—and the list goes on and on. The story has been—again, getting back to the fact that one size does not fit all—is that these specific DNA abnormalities predict for greater benefit from a class that we would call targeted therapies, than the relatively nonspecific chemotherapy, and the fact that these typically tend to be groups of patients that don't realize the same benefit from immunotherapy. ","_key":"34dde3ea52a2","_type":"span","marks":[]}]},{"style":"normal","_key":"e071a765d3b7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"So, the development of targeted therapies has been incredibly impactful on the outcomes of patients. And just in terms of looking to the future, we know that many of these targeted therapies induce a response, and that response may last 1, 2, 3, 4, even 5-plus years. And then one of the biggest challenges now is why do the tumors become resistant to the targeted therapy? Treating resistance to the original treatment is our next big challenge, and there are other targeted agents that are being developed specifically for those patients who develop certain resistance mechanisms to the first line of targeted therapies.","_key":"4b91160446f3"}],"_type":"block"},{"children":[{"_key":"e58e8f6b1e1f","_type":"span","marks":["strong"],"text":"Your past research suggests that low-grade immune-related adverse events may be associated with improved survival in advanced NSCLC treated with immune checkpoint inhibition. Could you discuss this finding?"}],"_type":"block","style":"normal","_key":"3a11f8b29f56","markDefs":[]},{"children":[{"_key":"fd32fd1011c70","_type":"span","marks":[],"text":"The use of immunotherapy is a strategy that tries to reengage the patient's immune system to fight the cancer. We know that can happen, and we also know that there are a long list of immune-related side effects. And what that suggests is that, in addition to targeting the patient's tumor, it is also targeting part of the normal patient. The common things we see are colitis; we see sometimes skin rash or dermatitis; we can see inflammation in the lungs; we commonly see thyroid alterations and these sorts of things, thinking that the immune system has become activated. And there have been small reports suggesting that if you had one of these immune-related adverse events, or side effects, if you will, that patients tended to do better. So the question came up, \"Is it just simply a sign of immune system activation?\""}],"_type":"block","style":"normal","_key":"bbbaea4fbeb7","markDefs":[]},{"_type":"block","style":"normal","_key":"e263955adc8a","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://jamanetwork.com/journals/jamaoncology/fullarticle/2801588","_key":"8922405d50c9"}],"children":[{"text":"The reports initially were relatively small, and we embarked on a ","_key":"e812810b1692","_type":"span","marks":[]},{"text":"large study of 3 large lung cancer trials ","_key":"55c6301bd531","_type":"span","marks":["8922405d50c9"]},{"_type":"span","marks":[],"text":"specifically trying to look at that in lung cancer, and made the observation that those patients that had some mild to moderate side effects that were felt to be immune-related did have better survival, suggesting that the immune system is turned on, and that that resulted in a benefit manifested as patients were living longer. The interesting thing is that if you had a high-grade or serious to life-threatening immune-mediated reaction, your survival was actually shorter, whether it was because you probably had to stop the immunotherapy or the side effect was more on the catastrophic side than if it were mild to moderate. What it taught and what I've said for a long time is we actually want a little bit of immune side effects—it seems to benefit the patient. But it's important for physicians to get the message that identifying the immune-mediated adverse events or side effects are important early on so that you can implement the appropriate supportive care, keep them from becoming life-threatening or serious, thereby allowing the patient to realize the benefit of immunotherapy. So I think that's the message. 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Socinski, MD, executive director at AdventHealth Cancer Institute, discussed the impacts of immunotherapy on outcomes for certain patients with non–small cell ","_key":"c5ed2d22bd660"},{"_type":"span","marks":["0d1a8d2bc38d"],"text":"lung cancer","_key":"507d51983b50"},{"text":". ","_key":"966a4bae00c2","_type":"span","marks":[]}]},{"children":[{"_type":"span","marks":[],"text":"","_key":"3dd3d5b47c23"}],"_type":"block","style":"normal","_key":"9d34ac53d8ca","markDefs":[]},{"_key":"1c65b81520b3","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"4ea737926197"}],"_type":"block","style":"normal"},{"children":[{"marks":["strong"],"text":"How has the growing list of immunotherapy options impacted the lung cancer treatment paradigm?","_key":"e7fa0a4c3d9e0","_type":"span"}],"_type":"block","style":"normal","_key":"b43481f59c0f","markDefs":[]},{"_key":"63c8b5117cc5","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"d6d291b3fd48"}],"_type":"block","style":"normal"},{"style":"normal","_key":"52f4eda842b3","markDefs":[],"children":[{"_type":"span","marks":[],"text":"If you look at cancer survival figures going back to around 2017, so 5 or 6 years ago, we've been seeing an annual reduction in cancer mortality in the United States. And, interestingly, if you look at the cancers that are leading the reduction in cancer mortality, it's principally 2 diseases that 20 or 30 years ago were felt to be diseases that do not get any significant benefit from treatment. It's melanoma and non–small cell lung cancer, the disease we're talking about today. ","_key":"1331b45372430"}],"_type":"block"},{"_type":"block","style":"normal","_key":"7a43ba38453e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"395cf13dd09b"}]},{"_key":"06101a71726d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Part of it is leveraging the immune system to mount an immune response specifically against the patient's tumor. The development of these PD-1/PD-L1 inhibitors as well as the CTLA-4 inhibitors, has really opened up the concept that a significant minority of patients can have very significant and very durable responses, meaning they last a long time—sometimes out to 5 years or so. And then, we're beginning to question, \"Are these patients cured of their cancer because of the immunotherapy?\"","_key":"899faed3462f"}],"_type":"block","style":"normal"},{"_key":"b70e36d95e01","markDefs":[],"children":[{"text":"","_key":"11d72a055193","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"children":[{"_key":"92f20b1183ed","_type":"span","marks":[],"text":"Now, I specifically said this is in a minority of patients, so it's important to think of this as a foot in the door if you will. We understand that our initial targets of PD-1 and CTLA-4 do change the outcome of patients and are leading to a reduction in cancer mortality, and we need to build on that. We need to understand other targets, and there are a number of investigational agents ongoing in this space in the form of clinical trials. 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Socinski, MD, discussed how the understanding of lung cancer has evolved over time, as well as how its heterogeneity impacts treatment strategies. 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Socinski, MD, executive director at AdventHealth Cancer Institute, explained how the understanding of ","_key":"ec5485691cff"},{"_type":"span","marks":["efe8bdc7feed"],"text":"lung cancer","_key":"7ddd0fa40ef5"},{"_type":"span","marks":[],"text":" has evolved in recent years, as well as how the heterogeneity of the disease impacts treatment decisions. ","_key":"8553da79b90f"}],"_type":"block","style":"normal","_key":"101679f26f1f"},{"_type":"block","style":"normal","_key":"d183c5f46b42","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"0d26e04d0668"}]},{"_key":"45499c03f4a6","markDefs":[],"children":[{"_key":"bada83fe6b55","_type":"span","marks":["strong","underline"],"text":"Transcript"}],"_type":"block","style":"normal"},{"_key":"9a2f5e608323","markDefs":[],"children":[{"_key":"57144b7bc21c0","_type":"span","marks":["strong"],"text":"Can you speak to the heterogeneity of lung cancer and why differentiation between subtypes is important?"}],"_type":"block","style":"normal"},{"_key":"59e5bf1b4cd8","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Historically, if you go back 30 years or so ago, we divided lung cancer into 2 major groups: non–small cell and small cell. 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","_key":"b1dbcee28ac9"}]},{"_type":"block","style":"normal","_key":"3b1198c2c86d","markDefs":[],"children":[{"_key":"15ed704b9421","_type":"span","marks":[],"text":""}]},{"_type":"block","style":"normal","_key":"e78d60852899","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Daly co-chaired ","_key":"945fefa3a185"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"11e91cf16c04"},{"_key":"7cf143307b06","_type":"span","marks":["superscript"],"text":"®"},{"_type":"span","marks":[],"text":"’s Institute for Value-Based Medicine","_key":"00f2f158419a"},{"text":"®","_key":"ab5e59259d07","_type":"span","marks":["superscript"]},{"_type":"span","marks":[],"text":" held on November 2 in New York City, where presenters discussed at-home and remote cancer treatments. He is a thoracic oncologist who specializes in lung cancer, as well as a health services researcher interested in innovative cancer care systems.","_key":"ff87f93c1791"}]},{"markDefs":[],"children":[{"text":"","_key":"38689747582c","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"aaabdbfa6ae1"},{"_key":"4523c44c26c4","markDefs":[],"children":[{"_key":"f6cfdc32d367","_type":"span","marks":["strong","underline"],"text":"Transcript"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":["strong"],"text":"Could you explain how at-home or remote treatment methods have affected your delivery of care to patients?","_key":"90ea780440520","_type":"span"}],"_type":"block","style":"normal","_key":"4c3d15782e41"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"1dafcbe75a39"}],"_type":"block","style":"normal","_key":"d39f6fa99881"},{"_type":"block","style":"normal","_key":"2407a6189887","markDefs":[],"children":[{"_type":"span","marks":[],"text":"A prime example of these new treatment methods is a pilot study we have ongoing right now at my institution where we're looking at the adoption of extended dosing of immunotherapy for patients with lung cancer. How we deliver that safely is by scheduling a televisit in between their infusional doses in order to do a toxicity check and ensure that they're tolerating the treatments safely. ","_key":"dc1685319bd80"}]},{"style":"normal","_key":"0fb7f72af80d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"cfb7405a1ea5"}],"_type":"block"},{"_type":"block","style":"normal","_key":"32c19519d2a2","markDefs":[],"children":[{"_type":"span","marks":[],"text":"These visits would otherwise have required those patients to come into the clinic in order to have that done. Now, we're able to do labs at the home and a televisit and provide that same service to ensure that they're getting their care safely. ","_key":"7482d97c36f7"}]},{"_type":"block","style":"normal","_key":"8e9fcdc0a689","markDefs":[],"children":[{"marks":[],"text":"","_key":"94229a3588ee","_type":"span"}]},{"style":"normal","_key":"b7274aafeb26","markDefs":[],"children":[{"_type":"span","marks":[],"text":"So, what does that mean for patients? It means rather than having to come in every 3 weeks, they can now come in every 6 weeks. For patients who are working, for patients who have travel plans, for patients who have dependents that they're taking care of, this has had a huge impact on their quality of life.","_key":"d9d22807421c"}],"_type":"block"},{"children":[{"_key":"e9041eb7de49","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"c335f4f9de74","markDefs":[]},{"style":"normal","_key":"8c8f542539e0","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"In the future, what innovations or changes in lung cancer treatment do you anticipate to have the most significant impact on patient outcomes?","_key":"90c648ba15810"}],"_type":"block"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"411475a0e8ce0","_type":"span"}],"_type":"block","style":"normal","_key":"8537811e5c6a"},{"_type":"block","style":"normal","_key":"121b52d99f73","markDefs":[],"children":[{"_key":"8de80b87a5fb0","_type":"span","marks":[],"text":"Well, one area where I'm really excited, and that ties together well with the virtual care, is subcutaneous immunotherapies. Now, there's the opportunity to potentially provide these lifesaving treatments for patients in the home because the delivery of those treatments now does not require an IV infusion. 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It's called the CALGB 140503 trial, and I have to give a major shoutout to Dr. Altorki, who was really the heart and soul of this trial and helped it to come to fruition. ","_key":"57753075f4a90","_type":"span","marks":[]}],"_type":"block"},{"_type":"block","style":"normal","_key":"ffe2fc19eb15","markDefs":[],"children":[{"text":"","_key":"bc8717c2e0ec","_type":"span","marks":[]}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The inspiration behind this was we're finding cancers that are smaller and smaller, our CT scans are getting better and better, we're finding subsolid lesions. The idea of taking out an entire lobe for something that sometimes comes back as just a couple of millimeters of invasive cancer really didn't feel like we're doing the right thing for patients. The historic precedent was always that we needed to do a lobectomy, and there were actually even trials establishing that as the definitive treatment from the Lung Cancer Study Group back in 1995.","_key":"0169157d8eec"}],"_type":"block","style":"normal","_key":"e7e1ba8e4eeb"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"1329414bed5e0"}],"_type":"block","style":"normal","_key":"821e92223b37"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Dr. Altorki put this really thoughtful trial together. He took tumors that were 2 centimeters or less with pathologically staged mediastinals. We had to actually sample 2 and 2 lymph node stations, and 1 and 1 lymph node station and send that all to pathology while the patient was on the operating table, and they would measure our tumor, they would check to make sure our lymph nodes were negative, and then we'd call them, and the patients were randomized to a lobar or sublobar resection. 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Actually, a little less of a decline than expected for the lobectomy patients, which is actually a good thing because that tells us we can also safely do a lobectomy for the patients who need it.","_key":"8656057ba2520","_type":"span"}],"_type":"block","style":"normal","_key":"d72dc87b31ae","markDefs":[]},{"style":"normal","_key":"ac9f913228af","markDefs":[],"children":[{"text":"","_key":"38c7969e5e540","_type":"span","marks":[]}],"_type":"block"},{"style":"normal","_key":"86936ce269ec","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The other piece to this, so disease-free survival was noninferior, so that's one of our oncologic outcomes, which is really critical. So, our disease-free survival is noninferior, and our overall survival is also noninferior for our sublobar resection group; we can do the surgery safely, and we can have a good oncologic outcome.","_key":"b9cd01ebef180"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"690133c9138b0"}],"_type":"block","style":"normal","_key":"8207787a2f3f"},{"style":"normal","_key":"fa6e4a0cc924","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The disappointing part of this study for all of us is the recurrence rates, and that's something that just disappoints us about lung cancer in general. As I sort of alluded to before, our recurrence rates, even for very small tumors, are about 35%. Gosh, that's a lot.","_key":"1125229844cc0"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"749834cbcf5a0"}],"_type":"block","style":"normal","_key":"0c05ce204610"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"So, a couple take-home messages from this. One, I think we need to continue to have a better understanding of tumor biology and what's driving these recurrences. Are there certain pathologic features? Are there certain pet features? Are there behavioral features that we can use to help guide additional therapy? Especially, which of these therapies do we need to be moving even into the earlier setting? 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I'm a robotic surgeon. I love robotics. I spend a lot of my time actually working with engineers to build new robots, to build new robotic devices, new instruments, and it has been one of the joys of my career to help start up a robotics program.","_key":"bfa1e6302f340"}],"_type":"block"},{"style":"normal","_key":"dacf40fcdc34","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"ac3c096ca23b0"}],"_type":"block"},{"_type":"block","style":"normal","_key":"dad1fd55f76d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Some of the advantages that I think, in general, when I think about minimally invasive—and that can include fats, and that can include robotics—is that we're making smaller incisions on patients. Many studies have helped to establish that patients who have these smaller incisions where we're not having to put retractors in their chest, we're not having to shingle their ribs, have less pain. They're staying in the hospital for shorter periods of time, we're not seeing any difference in other morbidities, so atrial fibrillation rates, things like that, which is great. And we can perform the surgeries really safely. So it’s safe, less painful, and we can get patients home sooner, which to me is a huge win.","_key":"ccbbf86096f40"}]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"a022d3d313630","_type":"span"}],"_type":"block","style":"normal","_key":"7a6a923ec0cf"},{"children":[{"_key":"878da1b9104b0","_type":"span","marks":[],"text":"One of the other huge advantages, in my opinion, when we think about doing minimally invasive procedures, especially when I think about robotics, is I have a 3D viewer, which is incredible. I'm able to zoom in on the anatomy a huge amount to be able to help with the conduct of the surgery, and we have so much mobility and flexibility with the wrists. They basically replicate the movements of human hands in a miniaturized version. This is basically like having a miniaturized version of \"Honey, I Shrunk the Kids\" style in your chest doing your surgery, which is really extraordinary."}],"_type":"block","style":"normal","_key":"1e8a7e7ac15a","markDefs":[]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"78c35f78c8b50","_type":"span"}],"_type":"block","style":"normal","_key":"adf4d430df27"},{"_key":"cd1fd061a622","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The technology has continued to advance over time to allow us to do more and more complex cases. We have seen this huge increase in minimally invasive surgeries, really, in particular, over the last decade, led by a lot of just really extraordinary teachers and master surgeons around the country who have been going around training people, all of our wonderful mentors, including those that I had, who trained me and my training and allowed me to go out and perform all these surgeries.","_key":"6d8880ec861e0"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a86eafe7320a0"}],"_type":"block","style":"normal","_key":"2acacdf0429d"},{"children":[{"text":"We're seeing a huge increase, but we're also seeing an increase in the complexity. We're doing pneumonectomies, sleeve resections, tracheal reconstructions, all sorts of really complex surgery, now minimally invasively, as we've been able to increase our comfort level, our skills, and as the technology has continued to get better.","_key":"49c8a13159570","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"315749043fe4","markDefs":[]},{"_type":"block","style":"normal","_key":"92f4a08cffaa","markDefs":[],"children":[{"marks":[],"text":"","_key":"59f27b30bf840","_type":"span"}]},{"style":"normal","_key":"6b04c8d41857","markDefs":[{"_type":"link","href":"https://www.ajmc.com/view/dr-erin-gillaspie-explains-how-to-discover-best-treatments-for-patients-with-lung-cancer","_key":"05d2468822d0","nofollow":false,"blank":true}],"children":[{"_type":"span","marks":[],"text":"The other big piece to this, and sort of the opposite end where we talked a little bit before about sort of ","_key":"7a93bd4f2a140"},{"_type":"span","marks":["05d2468822d0"],"text":"tissue being a big issue","_key":"268c911adf27"},{"text":", we've seen a huge expansion in some of the tools that our interventional pulmonologists that we as thoracic surgeons also use, and that's in the form of bronchoscopy. 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Gillaspie is a faculty member of VUMC’s Department of Thoracic Surgery and an assistant professor of thoracic surgery.","_key":"6c2daf31a0d4"}],"_type":"block","style":"normal","_key":"58edf074a1fc"},{"markDefs":[],"children":[{"marks":[],"text":"She also presented at ","_key":"0892d5ae4af0","_type":"span"},{"marks":["em"],"text":"The American Journal of Managed Care","_key":"5318f00527dc1","_type":"span"},{"_type":"span","marks":["superscript"],"text":"®","_key":"5318f00527dc2"},{"_type":"span","marks":[],"text":"’s Institute for Value-Based Medicine","_key":"61dba816b2fc"},{"text":"®","_key":"3ba77425824e","_type":"span","marks":["superscript"]},{"text":" held in Nashville, Tennessee, on August 17, 2023.","_key":"09c38ed25162","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"5c05b97fee91"},{"style":"normal","_key":"c352a4fdd19d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e700defcb0990"}],"_type":"block"},{"style":"normal","_key":"48da158d4b91","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"930845c53ec60"}],"_type":"block"},{"_type":"block","style":"normal","_key":"99368cfce112","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"aa32869ca5260"}]},{"_key":"74658c8d9974","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"What testing is needed to identify the best patients for certain treatments?","_key":"1e83cba2b7e20"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"text":"This is actually adding a layer of complexity to how we think about taking care of these patients now. One of the old adages we like to say all the time is \"tissue is the issue,\" but I think I mean that more than ever right now. Because now when we're thinking about making a new lung cancer diagnosis, not only do we want to know the histology—so we want a diagnosis, we want a histology—but we also want the opportunity to do things like PD-L1 (programmed cell death ligand 1) testing, molecular testing, because immunotherapy is not the right answer for everybody. We have other molecular alterations, targetable mutations, that have dedicated therapies for them.","_key":"be7b11346b020","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"f3638f981e93"},{"_key":"8d322272cd94","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"573b2660038c0"}],"_type":"block","style":"normal"},{"_key":"96ff03ca6739","markDefs":[],"children":[{"_type":"span","marks":[],"text":"I think about, in particular, a treatment like osimertinib for our patients who are eGFR (epidermal growth factor receptor) positive. There are 2 primary mutations that we use osimertinib for—that's the L858R mutation and the Exon 19 deletion. We already know that that's very, very efficacious in the adjuvant setting based on the ADAURA trial. We hardly ever have disease-free survival and overall survival curves like we did in that trial. In fact, the trial was stopped early because there was such a benefit in that treatment arm.","_key":"553da252badb0"}],"_type":"block","style":"normal"},{"_key":"2269caf7bcf7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"dfd34fcedac60"}],"_type":"block","style":"normal"},{"children":[{"marks":[],"text":"The NeoADAURA trial is actually ongoing to help establish the efficacy of that treatment in the neoadjuvant space. One of the things that's sort of unique about some of these mutations is some of them tend to be very immunologically cooled. So, what do I mean by that? Well, immunotherapy doesn't work particularly well for them.","_key":"37e76d0937f00","_type":"span"}],"_type":"block","style":"normal","_key":"eb97bc9b1b73","markDefs":[]},{"style":"normal","_key":"8f6c9c0e794d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"8030f628f344"}],"_type":"block"},{"style":"normal","_key":"1bf71974a976","markDefs":[],"children":[{"marks":[],"text":"One of the really common mutations that I think about for that is the Exon 19 deletion. If we're not testing for that ahead of time, if we don't know that ahead of time, and then we're putting this patient on immunotherapy, not only are we giving them potential risks without benefit, but we're also potentially affecting their ability to get the therapy that's really going to give them the best outcome, which is the osimertinib.","_key":"6fc353b82dbe","_type":"span"}],"_type":"block"},{"markDefs":[],"children":[{"_key":"4cb4c29f4a8b0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"2ebf1bd65030"},{"children":[{"_type":"span","marks":[],"text":"It's really important that we do 2 different things. One, we have to get enough tissue to make sure that we understand the right treatment regimens for that patient. If that's not something that we can get ahead of time with just a biopsy, that's where all of us are starting to say, “Okay, so maybe that's a patient we don't think about neoadjuvant therapy for; we get a good resection on them, and then we give them an adjuvant to make sure that we're getting them the right therapy.”","_key":"fde701bac2390"}],"_type":"block","style":"normal","_key":"4ad9d07853b5","markDefs":[]},{"markDefs":[],"children":[{"_key":"f6c41b5449580","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"e6bcdf1bf052"},{"markDefs":[],"children":[{"text":"The other piece to this is making sure we get the testing in a timely fashion. To that end, working within our teams, working with our pathology colleagues to say, “Okay, we need to get this testing back as fast as possible. 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I think, first and foremost, it impacts a huge number of people. Most people are somehow impacted by cancer, and, in particular, lung cancer. So it’s very, very common. We see it as one of our top 3 every single year in both men and women, but the other really important thing to note is it's a particularly lethal cancer.","_key":"9fd8280e37b90"}],"_type":"block","style":"normal"},{"style":"normal","_key":"c27e1adf0919","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a32cbb91a73c0"}],"_type":"block"},{"_type":"block","style":"normal","_key":"17a42df98c42","markDefs":[],"children":[{"_type":"span","marks":[],"text":"When we think about cancers, we think about sort of our mortality and our survival. Lung cancer, unfortunately, historically, has always scored really poorly. Our 5-year survival is nowhere near where any of us wants it to be, and we've seen really big improvements in some of the other cancer types. So, breast and colon, where we've seen a huge amount of wonderful research, and funding for that research help to make massive advances. Lung cancer is a little lagging behind, but we're now starting to get some great momentum in that space as well. It's important to know that lung cancer remains the number 1 cancer killer.","_key":"386d7d16ebb00"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7eac439c1fc30"}],"_type":"block","style":"normal","_key":"a554fba5f8b9"},{"_key":"1afd55039362","markDefs":[{"_type":"link","href":"https://www.cancer.gov/types/lung/research/nlst","_key":"62b591f638f4","nofollow":true,"blank":true}],"children":[{"_type":"span","marks":[],"text":"So, what are some of the big changes that we see that's having a huge impact on that? 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We do mammograms for breast cancer screening, we do colonoscopies for colon cancer screening, we do pap smears, but for a long time, we actually had nothing in lung cancer, because chest x-rays really actually weren't helping us to catch things sooner and faster. This brilliant trial came out looking at the use of low-dose CT scans that's using about the same amount of radiation as a chest X ray but in CT scan format. It allows us to see the lungs much more clearly in much greater detail to try to identify cancers sooner.","_key":"cb9c40bb99210"}]},{"children":[{"_type":"span","marks":[],"text":"","_key":"07f1e308031f0"}],"_type":"block","style":"normal","_key":"8f056453b7b4","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"For people who are higher risk, what category of people is that? So, it’s people 50 to 80 who have at least 20-year pack-year smoking history who are current smokers or who have quit sort of within the last 15 years. For those folks, we’re able to do lung cancer screening. Our primary care doctors are so wonderful about asking patients about it, but we really want our patients as well to be asking, “Do I meet the criteria for this?” It's a great opportunity to define things sooner.","_key":"f259dec4361c0"}],"_type":"block","style":"normal","_key":"dcd173c44054","markDefs":[]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"013af927ff850","_type":"span"}],"_type":"block","style":"normal","_key":"3886b8fe835c"},{"_type":"block","style":"normal","_key":"f81b00b1f2ec","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Since we've started developing lung cancer screening programs around the country, we've started to see a change in when we're diagnosing lung cancer. Most lung cancer is diagnosed in stage IV, and that's because most people don't have any symptoms when they have lung cancer. Usually, a cancer has to get pretty big or be in a particular location before people start having symptoms from it, so this allows us to catch up before those symptoms. We're starting to see a little bit of a shift, we call it a stage shift, so more people getting caught in that stage I, and that has a huge impact on survival.","_key":"3cea56f085800"}]},{"_key":"5e2dada9f140","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"837935dc040c0"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"dcac70c71f61","markDefs":[],"children":[{"_type":"span","marks":[],"text":"We're also living in an immunotherapy and molecular era, and it is so exciting, [that] all of these new therapies are being developed to specifically target some of the mutations in cancer, to help leverage the immune system to attack cancer. 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Socinski","_key":"0ba3e1b84417","_type":"span","marks":["7362957e4d97"]},{"marks":[],"text":", MD, executive director of AdventHealth Cancer Institute, gave insight into treatment resistance and the importance of repeat biomarker testing at the time of disease progression in non–small cell lung cancer (NSCLC). ","_key":"7c0d77535fa7","_type":"span"}],"_type":"block","style":"normal","_key":"452af30c3adc"},{"_key":"e0d4fdb08790","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a8ecf298131c"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"ebaf72bf7f12"}],"_type":"block","style":"normal","_key":"91e635560b34"},{"style":"normal","_key":"a37d31e274c7","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"How do you approach the issue of drug resistance in patients with NSCLC in your clinical practice?","_key":"9e6ea5a76c270"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"We've developed a whole new generation of first-line drugs that are highly effective—but, particularly in the arena of targeted therapies, we know that at some point, acquired resistance is going to happen. Again, there are increasing amounts of information about acquired resistance patterns, some of which do have targetable options with it. The best example is in the ","_key":"f57d3e03262b0"},{"_type":"span","marks":["em"],"text":"EGFR ","_key":"8201fa98f9e1"},{"text":"mutation–positive space. Using osimertinib, one of the more common acquired resistance mechanisms is MET amplification. We do have a couple of MET drugs that are FDA approved; we have a couple of early studies that look at binding the MET inhibitors with osimertinib in patients who have MET amplification. And you do see clinical benefit there. ","_key":"3473c9a61f6a","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"4eba876fea83"},{"children":[{"_type":"span","marks":[],"text":"We also know that there are other bypass tracks that may happen that may have a targeted therapy. So I think the approach to the resistance issue is the concept of retesting at the time of progression, so that you can understand if there is an acquired resistance mechanism that might have a targeted therapy associated with it. Oftentimes, you won't find something like that. But I think the message of dealing with resistance is retesting to see what may be there. Can you identify a mechanism of acquired resistance that may have a different treatment option for the patient? 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