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Available in 13 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-13" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">13 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-az mw-list-item"><a href="https://az.wikipedia.org/wiki/Betriksaban" title="Betriksaban – Azerbaijani" lang="az" hreflang="az" data-title="Betriksaban" data-language-autonym="Azərbaycanca" data-language-local-name="Azerbaijani" class="interlanguage-link-target"><span>Azərbaycanca</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Betrixaban" title="Betrixaban – Spanish" lang="es" hreflang="es" data-title="Betrixaban" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A8%D8%AA%D8%B1%DB%8C%DA%A9%D8%B3%D8%A7%D8%A8%D8%A7%D9%86" title="بتریکسابان – Persian" lang="fa" hreflang="fa" data-title="بتریکسابان" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/B%C3%A9trixaban" title="Bétrixaban – French" lang="fr" hreflang="fr" data-title="Bétrixaban" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Betrixaban" title="Betrixaban – Italian" lang="it" hreflang="it" data-title="Betrixaban" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-sw mw-list-item"><a href="https://sw.wikipedia.org/wiki/Betriksabani" title="Betriksabani – Swahili" lang="sw" hreflang="sw" data-title="Betriksabani" data-language-autonym="Kiswahili" data-language-local-name="Swahili" class="interlanguage-link-target"><span>Kiswahili</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%AC%E0%AD%87%E0%AC%9F%E0%AD%8D%E0%AC%B0%E0%AC%BF%E0%AC%95%E0%AD%8D%E0%AC%B8%E0%AC%BE%E0%AC%AC%E0%AC%BE%E0%AC%A8" title="ବେଟ୍ରିକ୍ସାବାନ – Odia" lang="or" hreflang="or" data-title="ବେଟ୍ରିକ୍ସାବାନ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Betrixabano" title="Betrixabano – Portuguese" lang="pt" hreflang="pt" data-title="Betrixabano" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Betrixaban" title="Betrixaban – Romanian" lang="ro" hreflang="ro" data-title="Betrixaban" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%91%D0%B5%D1%82%D1%80%D0%B8%D0%BA%D1%81%D0%B0%D0%B1%D0%B0%D0%BD" title="Бетриксабан – Russian" lang="ru" hreflang="ru" data-title="Бетриксабан" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Betriksaban" title="Betriksaban – Serbian" lang="sr" hreflang="sr" data-title="Betriksaban" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Betriksaban" title="Betriksaban – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Betriksaban" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-te mw-list-item"><a href="https://te.wikipedia.org/wiki/%E0%B0%AC%E0%B1%86%E0%B0%9F%E0%B1%8D%E0%B0%B0%E0%B0%BF%E0%B0%95%E0%B1%8D%E0%B0%B8%E0%B0%BE%E0%B0%AC%E0%B0%BE%E0%B0%A8%E0%B1%8D" title="బెట్రిక్సాబాన్ – Telugu" lang="te" hreflang="te" data-title="బెట్రిక్సాబాన్" data-language-autonym="తెలుగు" data-language-local-name="Telugu" class="interlanguage-link-target"><span>తెలుగు</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q4898219#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li 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.mbox-image-div{width:52px}@media(min-width:720px){.mw-parser-output .ambox{margin:0 10%}}@media print{body.ns-0 .mw-parser-output .ambox{display:none!important}}</style><table class="box-Medical_citations_needed plainlinks metadata ambox ambox-content" role="presentation"><tbody><tr><td class="mbox-image"><div class="mbox-image-div"><span typeof="mw:File"><span><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/b/b4/Ambox_important.svg/40px-Ambox_important.svg.png" decoding="async" width="40" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/b/b4/Ambox_important.svg/60px-Ambox_important.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/b/b4/Ambox_important.svg/80px-Ambox_important.svg.png 2x" data-file-width="40" data-file-height="40" /></span></span></div></td><td class="mbox-text"><div class="mbox-text-span">This article <b>needs more <a href="/wiki/Wikipedia:Identifying_reliable_sources_(medicine)" title="Wikipedia:Identifying reliable sources (medicine)">reliable medical references</a> for <a href="/wiki/Wikipedia:Verifiability" title="Wikipedia:Verifiability">verification</a> or relies too heavily on <a href="/wiki/Wikipedia:Primary_sources" class="mw-redirect" title="Wikipedia:Primary sources">primary sources</a></b>.<span class="hide-when-compact"> Please review the contents of the article and <a class="external text" href="https://en.wikipedia.org/w/index.php?title=Betrixaban&action=edit">add the appropriate references</a> if you can. Unsourced or poorly sourced material may be challenged and <a href="/wiki/Wikipedia:Verifiability#Burden_of_evidence" title="Wikipedia:Verifiability">removed</a>. <small><span class="plainlinks"><i>Find sources:</i> <a rel="nofollow" class="external text" href="https://www.google.com/search?as_eq=wikipedia&q=%22Betrixaban%22">"Betrixaban"</a> – <a rel="nofollow" class="external text" href="https://www.google.com/search?tbm=nws&q=%22Betrixaban%22+-wikipedia&tbs=ar:1">news</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.google.com/search?&q=%22Betrixaban%22&tbs=bkt:s&tbm=bks">newspapers</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.google.com/search?tbs=bks:1&q=%22Betrixaban%22+-wikipedia">books</a> <b>·</b> <a rel="nofollow" class="external text" href="https://scholar.google.com/scholar?q=%22Betrixaban%22">scholar</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.jstor.org/action/doBasicSearch?Query=%22Betrixaban%22&acc=on&wc=on">JSTOR</a></span></small></span> <span class="date-container"><i>(<span class="date">November 2018</span>)</i></span></div></td><td class="mbox-imageright"><div class="mbox-image-div"><span typeof="mw:File"><span><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Star_of_life.svg/52px-Star_of_life.svg.png" decoding="async" width="52" height="50" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Star_of_life.svg/77px-Star_of_life.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Star_of_life.svg/103px-Star_of_life.svg.png 2x" data-file-width="198" data-file-height="192" /></span></span></div></td></tr></tbody></table> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Betrixaban">Betrixaban</span></caption><tbody><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span typeof="mw:File"><a href="/wiki/File:Betrixaban.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Betrixaban.svg/220px-Betrixaban.svg.png" decoding="async" width="220" height="186" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Betrixaban.svg/330px-Betrixaban.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Betrixaban.svg/440px-Betrixaban.svg.png 2x" data-file-width="512" data-file-height="433" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Bevyxxa</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">PRT054021, PRT064445</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/bevyxxa.html">bevyxxa</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Oral_administration" title="Oral administration">By mouth</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"><ul><li><a href="/wiki/ATC_code_B01" title="ATC code B01">B01AF04</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=B01AF04">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">℞-only</a></li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd"><a href="/wiki/Pharmacokinetics" title="Pharmacokinetics">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Plasma_protein_binding" title="Plasma protein binding">Protein binding</a></th><td class="infobox-data">60%</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Biological_half-life" title="Biological half-life">Elimination <span class="nowrap">half-life</span></a></th><td class="infobox-data">19–27 hrs</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pharmacodynamics#Duration_of_action" title="Pharmacodynamics">Duration of action</a></th><td class="infobox-data">≥72 hrs</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Excretion" title="Excretion">Excretion</a></th><td class="infobox-data">85% feces, 11% urine</td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;"><i>N</i>-(5-Chloropyridin-2-yl)-2-([4-(<i>N</i>,<i>N</i>-dimethylcarbamimidoyl)benzoyl]amino)-5-methoxybenzamide</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=330942-05-7">330942-05-7</a></span><sup> <span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/10275777">10275777</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB12364">DB12364</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.18981107.html">18981107</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/74RWP7W0J9">74RWP7W0J9</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D08873">D08873</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:140421">CHEBI:140421</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/ChEMBL512351">ChEMBL512351</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID10954727">DTXSID10954727</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q4898219#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ECHA_InfoCard" class="mw-redirect" title="ECHA InfoCard"><span title="echa.europa.eu">ECHA InfoCard</span></a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.207.746">100.207.746</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q4898219#P2566" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>23</sub><span title="Hydrogen">H</span><sub>22</sub><span title="Chlorine">Cl</span><span title="Nitrogen">N</span><sub>5</sub><span title="Oxygen">O</span><sub>3</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7002451910000000000♠"></span>451.91</span> g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=CN%28C%29C%28%3DN%29C1%3DCC%3DC%28C%3DC1%29C%28%3DO%29NC2%3DC%28C%3DC%28C%3DC2%29OC%29C%28%3DO%29NC3%3DNC%3DC%28C%3DC3%29Cl">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">CN(C)C(=N)C1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)OC)C(=O)NC3=NC=C(C=C3)Cl</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C23H22ClN5O3/c1-29(2)21(25)14-4-6-15(7-5-14)22(30)27-19-10-9-17(32-3)12-18(19)23(31)28-20-11-8-16(24)13-26-20/h4-13,25H,1-3H3,(H,27,30)(H,26,28,31)<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:XHOLNRLADUSQLD-UHFFFAOYSA-N<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-below"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style><span class="nobold"> <sup><span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span><span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup> <a href="/wiki/Wikipedia:WikiProject_Chemicals/Chembox_validation" title="Wikipedia:WikiProject Chemicals/Chembox validation">(what is this?)</a></span><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488"><span class="nobold">  <span class="reflink plainlinks nourlexpansion"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Special:ComparePages&rev1=461744356&page2=Betrixaban">(verify)</a></span></span></td></tr></tbody></table> <p><b>Betrixaban</b> (trade name <b>Bevyxxa</b>) is an oral <a href="/wiki/Anticoagulant" title="Anticoagulant">anticoagulant</a> drug which acts as a <a href="/wiki/Direct_factor_Xa_inhibitor" class="mw-redirect" title="Direct factor Xa inhibitor">direct factor Xa inhibitor</a>.<sup id="cite_ref-pmid19071881_1-0" class="reference"><a href="#cite_note-pmid19071881-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Betrixaban is <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">FDA</a> approved for <a href="/wiki/Venous_thrombosis" title="Venous thrombosis">venous thrombosis</a> prevention in adults hospitalized for an <a href="/wiki/Acute_(medicine)" title="Acute (medicine)">acute</a> illness who are at risk for thromboembolic complications.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Compared to other <a href="/wiki/Directly_acting_oral_anticoagulants" class="mw-redirect" title="Directly acting oral anticoagulants">directly acting oral anticoagulants</a> betrixaban has relatively low <a href="/wiki/Clearance_(pharmacology)" title="Clearance (pharmacology)">renal excretion</a> and is not metabolized by <a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a>.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Betrixaban&action=edit&section=1" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Betrixaban was originally developed by <a href="/wiki/Millennium_Pharmaceuticals" class="mw-redirect" title="Millennium Pharmaceuticals">Millennium Pharmaceuticals</a>. <a href="/wiki/Portola_Pharmaceuticals" title="Portola Pharmaceuticals">Portola Pharmaceuticals</a> acquired rights for betrixaban in 2004 and co-developed it with <a href="/wiki/Merck_%26_Co." title="Merck & Co.">Merck</a>. In 2011 Merck discontinued joint development.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p>The drug has undergone <a href="/wiki/Clinical_trials" class="mw-redirect" title="Clinical trials">clinical trials</a> for prevention of embolism after <a href="/wiki/Knee" title="Knee">knee</a> surgery<sup id="cite_ref-pmid19132191_5-0" class="reference"><a href="#cite_note-pmid19132191-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> and for prevention of <a href="/wiki/Stroke" title="Stroke">stroke</a> following non-valvular <a href="/wiki/Atrial_fibrillation" title="Atrial fibrillation">atrial fibrillation</a>.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Betrixaban was also studied in a large phase III clinical trial for extended duration <a href="/wiki/Thromboprophylaxis" class="mw-redirect" title="Thromboprophylaxis">thromboprophylaxis</a> in acute ill patients.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Previously <a href="/wiki/Apixaban" title="Apixaban">apixaban</a> and <a href="/wiki/Rivaroxaban" title="Rivaroxaban">rivaroxaban</a> have failed to show positive risk/benefit ratio in this indication compared to <a href="/wiki/Enoxaparin_sodium" title="Enoxaparin sodium">enoxaparin</a>.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup class="noprint Inline-Template noprint Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:No_original_research#Primary,_secondary_and_tertiary_sources" title="Wikipedia:No original research"><span title="This claim needs references to reliable secondary sources. (November 2020)">non-primary source needed</span></a></i>]</sup> APEX trial compared betrixaban with <a href="/wiki/Enoxaparin_sodium" title="Enoxaparin sodium">enoxaparin</a> and included 7513 patients. Lower rate of VTE events was found in betrixaban arm with no increase in major bleedings compared to enoxaparin.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Based on these results betrixaban was approved by FDA on June 23, 2017, becoming the first DOAC approved for extended prophylaxis in hospitalized patients.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p><p>Betrixaban has been also reviewed by <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">EMA</a> but didn't receive marketing approval in <a href="/wiki/European_Union" title="European Union">EU</a> mainly due to concerns of increased bleeding risk and absence of reversal agent.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Betrixaban&action=edit&section=2" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Edoxaban" title="Edoxaban">Edoxaban</a></li> <li><a href="/wiki/Enoxaparin" class="mw-redirect" title="Enoxaparin">Enoxaparin</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Betrixaban&action=edit&section=3" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-pmid19071881-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid19071881_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFErikssonQuinlanWeitz2009" class="citation journal cs1">Eriksson BI, Quinlan DJ, Weitz JI (2009). "Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development". <i>Clinical Pharmacokinetics</i>. <b>48</b> (1): 1–22. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2165%2F0003088-200948010-00001">10.2165/0003088-200948010-00001</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19071881">19071881</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:35948814">35948814</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Clinical+Pharmacokinetics&rft.atitle=Comparative+pharmacodynamics+and+pharmacokinetics+of+oral+direct+thrombin+and+factor+xa+inhibitors+in+development&rft.volume=48&rft.issue=1&rft.pages=1-22&rft.date=2009&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A35948814%23id-name%3DS2CID&rft_id=info%3Apmid%2F19071881&rft_id=info%3Adoi%2F10.2165%2F0003088-200948010-00001&rft.aulast=Eriksson&rft.aufirst=BI&rft.au=Quinlan%2C+DJ&rft.au=Weitz%2C+JI&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABetrixaban" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/drugs/informationondrugs/approveddrugs/ucm564422.htm">"Approved Drugs - FDA approved betrixaban (BEVYXXA, Portola) for the prophylaxis of venous thromboembolism (VTE) in adult patients"</a>. <i>Center for Drug Evaluation and Research (CDER)</i>. U.S. Food and Drug Administration<span class="reference-accessdate">. Retrieved <span class="nowrap">2018-10-29</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Center+for+Drug+Evaluation+and+Research+%28CDER%29&rft.atitle=Approved+Drugs+-+FDA+approved+betrixaban+%28BEVYXXA%2C+Portola%29+for+the+prophylaxis+of+venous+thromboembolism+%28VTE%29+in+adult+patients&rft_id=https%3A%2F%2Fwww.fda.gov%2Fdrugs%2Finformationondrugs%2Fapproveddrugs%2Fucm564422.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABetrixaban" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHuismanKlok2018" class="citation journal cs1">Huisman MV, Klok FA (May 2018). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016700">"Pharmacological properties of betrixaban"</a>. <i>European Heart Journal Supplements</i>. <b>20</b> (Suppl E): E12–E15. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Feurheartj%2Fsuy016">10.1093/eurheartj/suy016</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016700">6016700</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/29977164">29977164</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=European+Heart+Journal+Supplements&rft.atitle=Pharmacological+properties+of+betrixaban&rft.volume=20&rft.issue=Suppl+E&rft.pages=E12-E15&rft.date=2018-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6016700%23id-name%3DPMC&rft_id=info%3Apmid%2F29977164&rft_id=info%3Adoi%2F10.1093%2Feurheartj%2Fsuy016&rft.aulast=Huisman&rft.aufirst=MV&rft.au=Klok%2C+FA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6016700&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABetrixaban" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHusten2011" class="citation web cs1">Husten H (24 March 2011). <a rel="nofollow" class="external text" href="http://cardiobrief.org/2011/03/24/merck-abandons-development-of-factor-xa-inhibitor-betrixaban/">"Merck Abandons Development of Factor Xa Inhibitor Betrixaban"</a>. CardioBrief<span class="reference-accessdate">. Retrieved <span class="nowrap">11 April</span> 2014</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Merck+Abandons+Development+of+Factor+Xa+Inhibitor+Betrixaban&rft.pub=CardioBrief&rft.date=2011-03-24&rft.aulast=Husten&rft.aufirst=H&rft_id=http%3A%2F%2Fcardiobrief.org%2F2011%2F03%2F24%2Fmerck-abandons-development-of-factor-xa-inhibitor-betrixaban%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABetrixaban" class="Z3988"></span></span> </li> <li id="cite_note-pmid19132191-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid19132191_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTurpieBauerDavidsonFisher2009" class="citation journal cs1">Turpie AG, Bauer KA, Davidson BL, Fisher WD, Gent M, Huo MH, et al. (January 2009). "A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT)". <i>Thrombosis and Haemostasis</i>. <b>101</b> (1): 68–76. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1160%2Fth08-07-0460">10.1160/th08-07-0460</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19132191">19132191</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:21670373">21670373</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Thrombosis+and+Haemostasis&rft.atitle=A+randomized+evaluation+of+betrixaban%2C+an+oral+factor+Xa+inhibitor%2C+for+prevention+of+thromboembolic+events+after+total+knee+replacement+%28EXPERT%29&rft.volume=101&rft.issue=1&rft.pages=68-76&rft.date=2009-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A21670373%23id-name%3DS2CID&rft_id=info%3Apmid%2F19132191&rft_id=info%3Adoi%2F10.1160%2Fth08-07-0460&rft.aulast=Turpie&rft.aufirst=AG&rft.au=Bauer%2C+KA&rft.au=Davidson%2C+BL&rft.au=Fisher%2C+WD&rft.au=Gent%2C+M&rft.au=Huo%2C+MH&rft.au=Sinha%2C+U&rft.au=Gretler%2C+DD&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABetrixaban" class="Z3988"></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPicciniLopesMahaffey2010" class="citation journal cs1">Piccini JP, Lopes RD, Mahaffey KW (July 2010). "Oral factor Xa inhibitors for the prevention of stroke in atrial fibrillation". <i>Current Opinion in Cardiology</i>. <b>25</b> (4): 312–320. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FHCO.0b013e32833a524f">10.1097/HCO.0b013e32833a524f</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20520539">20520539</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:25718628">25718628</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Opinion+in+Cardiology&rft.atitle=Oral+factor+Xa+inhibitors+for+the+prevention+of+stroke+in+atrial+fibrillation&rft.volume=25&rft.issue=4&rft.pages=312-320&rft.date=2010-07&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A25718628%23id-name%3DS2CID&rft_id=info%3Apmid%2F20520539&rft_id=info%3Adoi%2F10.1097%2FHCO.0b013e32833a524f&rft.aulast=Piccini&rft.aufirst=JP&rft.au=Lopes%2C+RD&rft.au=Mahaffey%2C+KW&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABetrixaban" class="Z3988"></span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSobieraj-TeagueO'DonnellEikelboom2009" class="citation journal cs1">Sobieraj-Teague M, O'Donnell M, Eikelboom J (July 2009). <a rel="nofollow" class="external text" href="https://doi.org/10.1055%2Fs-0029-1234147">"New anticoagulants for atrial fibrillation"</a>. <i>Seminars in Thrombosis and Hemostasis</i>. <b>35</b> (5): 515–524. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1055%2Fs-0029-1234147">10.1055/s-0029-1234147</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19739042">19739042</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Seminars+in+Thrombosis+and+Hemostasis&rft.atitle=New+anticoagulants+for+atrial+fibrillation&rft.volume=35&rft.issue=5&rft.pages=515-524&rft.date=2009-07&rft_id=info%3Adoi%2F10.1055%2Fs-0029-1234147&rft_id=info%3Apmid%2F19739042&rft.aulast=Sobieraj-Teague&rft.aufirst=M&rft.au=O%27Donnell%2C+M&rft.au=Eikelboom%2C+J&rft_id=https%3A%2F%2Fdoi.org%2F10.1055%252Fs-0029-1234147&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABetrixaban" class="Z3988"></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-8">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCohenHarringtonGoldhaberHull2014" class="citation journal cs1">Cohen AT, Harrington R, Goldhaber SZ, Hull R, Gibson CM, Hernandez AF, et al. (March 2014). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.ahj.2013.11.006">"The design and rationale for the Acute Medically Ill Venous Thromboembolism Prevention with Extended Duration Betrixaban (APEX) study"</a>. <i>American Heart Journal</i>. <b>167</b> (3): 335–341. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.ahj.2013.11.006">10.1016/j.ahj.2013.11.006</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24576517">24576517</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=American+Heart+Journal&rft.atitle=The+design+and+rationale+for+the+Acute+Medically+Ill+Venous+Thromboembolism+Prevention+with+Extended+Duration+Betrixaban+%28APEX%29+study&rft.volume=167&rft.issue=3&rft.pages=335-341&rft.date=2014-03&rft_id=info%3Adoi%2F10.1016%2Fj.ahj.2013.11.006&rft_id=info%3Apmid%2F24576517&rft.aulast=Cohen&rft.aufirst=AT&rft.au=Harrington%2C+R&rft.au=Goldhaber%2C+SZ&rft.au=Hull%2C+R&rft.au=Gibson%2C+CM&rft.au=Hernandez%2C+AF&rft.au=Kitt%2C+MM&rft.au=Lorenz%2C+TJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.ahj.2013.11.006&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABetrixaban" class="Z3988"></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCohenSpiroBüllerHaskell2013" class="citation journal cs1">Cohen AT, Spiro TE, Büller HR, Haskell L, Hu D, Hull R, et al. (February 2013). "Rivaroxaban for thromboprophylaxis in acutely ill medical patients". <i>The New England Journal of Medicine</i>. <b>368</b> (6): 513–523. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1056%2Fnejmoa1111096">10.1056/nejmoa1111096</a>. <a href="/wiki/Hdl_(identifier)" class="mw-redirect" title="Hdl (identifier)">hdl</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://hdl.handle.net/10447%2F96593">10447/96593</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23388003">23388003</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=Rivaroxaban+for+thromboprophylaxis+in+acutely+ill+medical+patients&rft.volume=368&rft.issue=6&rft.pages=513-523&rft.date=2013-02&rft_id=info%3Ahdl%2F10447%2F96593&rft_id=info%3Apmid%2F23388003&rft_id=info%3Adoi%2F10.1056%2Fnejmoa1111096&rft.aulast=Cohen&rft.aufirst=AT&rft.au=Spiro%2C+TE&rft.au=B%C3%BCller%2C+HR&rft.au=Haskell%2C+L&rft.au=Hu%2C+D&rft.au=Hull%2C+R&rft.au=Mebazaa%2C+A&rft.au=Merli%2C+G&rft.au=Schellong%2C+S&rft.au=Spyropoulos%2C+AC&rft.au=Tapson%2C+V&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABetrixaban" class="Z3988"></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGoldhaberLeizoroviczKakkarHaas2011" class="citation journal cs1">Goldhaber SZ, Leizorovicz A, Kakkar AK, Haas SK, Merli G, Knabb RM, Weitz JI (December 2011). "Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients". <i>The New England Journal of Medicine</i>. <b>365</b> (23): 2167–2177. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1056%2Fnejmoa1110899">10.1056/nejmoa1110899</a>. <a href="/wiki/Hdl_(identifier)" class="mw-redirect" title="Hdl (identifier)">hdl</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://hdl.handle.net/2437%2F127244">2437/127244</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22077144">22077144</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=Apixaban+versus+enoxaparin+for+thromboprophylaxis+in+medically+ill+patients&rft.volume=365&rft.issue=23&rft.pages=2167-2177&rft.date=2011-12&rft_id=info%3Ahdl%2F2437%2F127244&rft_id=info%3Apmid%2F22077144&rft_id=info%3Adoi%2F10.1056%2Fnejmoa1110899&rft.aulast=Goldhaber&rft.aufirst=SZ&rft.au=Leizorovicz%2C+A&rft.au=Kakkar%2C+AK&rft.au=Haas%2C+SK&rft.au=Merli%2C+G&rft.au=Knabb%2C+RM&rft.au=Weitz%2C+JI&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABetrixaban" class="Z3988"></span></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-11">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCohenHarringtonGoldhaberHull2016" class="citation journal cs1">Cohen AT, Harrington RA, Goldhaber SZ, Hull RD, Wiens BL, Gold A, et al. (August 2016). <a rel="nofollow" class="external text" href="https://doi.org/10.1056%2Fnejmoa1601747">"Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients"</a>. <i>The New England Journal of Medicine</i>. <b>375</b> (6): 534–544. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1056%2Fnejmoa1601747">10.1056/nejmoa1601747</a></span>. <a href="/wiki/Hdl_(identifier)" class="mw-redirect" title="Hdl (identifier)">hdl</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://hdl.handle.net/11573%2F884978">11573/884978</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27232649">27232649</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=Extended+Thromboprophylaxis+with+Betrixaban+in+Acutely+Ill+Medical+Patients&rft.volume=375&rft.issue=6&rft.pages=534-544&rft.date=2016-08&rft_id=info%3Ahdl%2F11573%2F884978&rft_id=info%3Apmid%2F27232649&rft_id=info%3Adoi%2F10.1056%2Fnejmoa1601747&rft.aulast=Cohen&rft.aufirst=AT&rft.au=Harrington%2C+RA&rft.au=Goldhaber%2C+SZ&rft.au=Hull%2C+RD&rft.au=Wiens%2C+BL&rft.au=Gold%2C+A&rft.au=Hernandez%2C+AF&rft.au=Gibson%2C+CM&rft_id=https%3A%2F%2Fdoi.org%2F10.1056%252Fnejmoa1601747&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABetrixaban" class="Z3988"></span></span> </li> <li id="cite_note-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-12">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm564422.htm">"FDA approved betrixaban (BEVYXXA, Portola) for the prophylaxis of venous thromboembolism (VTE) in adult patients"</a>. <i><a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a></i><span class="reference-accessdate">. Retrieved <span class="nowrap">28 June</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Food+and+Drug+Administration&rft.atitle=FDA+approved+betrixaban+%28BEVYXXA%2C+Portola%29+for+the+prophylaxis+of+venous+thromboembolism+%28VTE%29+in+adult+patients&rft_id=https%3A%2F%2Fwww.fda.gov%2FDrugs%2FInformationOnDrugs%2FApprovedDrugs%2Fucm564422.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABetrixaban" class="Z3988"></span></span> </li> <li id="cite_note-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-13">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/documents/smop-initial/questions-answers-refusal-marketing-authorisation-dexxience-betrixaban_en.pdf">"Refusal of the marketing authorisation for Dexxience (betrixaban): Outcome of re-examination"</a> <span class="cs1-format">(PDF)</span>. <i>Committee for Medicinal Products for Human Use (CHMP)</i>. European Medicines Agency. 27 July 2018.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Committee+for+Medicinal+Products+for+Human+Use+%28CHMP%29&rft.atitle=Refusal+of+the+marketing+authorisation+for+Dexxience+%28betrixaban%29%3A+Outcome+of+re-examination&rft.date=2018-07-27&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fdocuments%2Fsmop-initial%2Fquestions-answers-refusal-marketing-authorisation-dexxience-betrixaban_en.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABetrixaban" class="Z3988"></span></span> </li> </ol></div></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline 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.navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Antithrombotics" title="Template:Antithrombotics"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Antithrombotics" title="Template talk:Antithrombotics"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Antithrombotics" title="Special:EditPage/Template:Antithrombotics"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Antithrombotics_(thrombolytics,_anticoagulants_and_antiplatelet_drugs)_(B01)" style="font-size:114%;margin:0 4em"><a href="/wiki/Antithrombotic" title="Antithrombotic">Antithrombotics</a> (<a href="/wiki/Thrombolytic_drug" class="mw-redirect" title="Thrombolytic drug">thrombolytics</a>, <a href="/wiki/Anticoagulant" title="Anticoagulant">anticoagulants</a> and <a href="/wiki/Antiplatelet_drug" title="Antiplatelet drug">antiplatelet drugs</a>) (<a href="/wiki/ATC_code_B01" title="ATC code B01">B01</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Antiplatelet_drug" title="Antiplatelet drug">Antiplatelet drugs</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Glycoprotein_IIb/IIIa_inhibitors" title="Glycoprotein IIb/IIIa inhibitors">Glycoprotein IIb/IIIa inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Abciximab" title="Abciximab">Abciximab</a></li> <li><a href="/wiki/Eptifibatide" title="Eptifibatide">Eptifibatide</a></li> <li><a href="/w/index.php?title=Orbofiban&action=edit&redlink=1" class="new" title="Orbofiban (page does not exist)">Orbofiban</a></li> <li><a href="/w/index.php?title=Roxifiban&action=edit&redlink=1" class="new" title="Roxifiban (page does not exist)">Roxifiban</a></li> <li><a href="/wiki/Sibrafiban" title="Sibrafiban">Sibrafiban</a><sup>§</sup></li> <li><a href="/wiki/Tirofiban" title="Tirofiban">Tirofiban</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/P2Y12" title="P2Y12">ADP receptor/P2Y<sub>12</sub></a> <a href="/wiki/Adenosine_diphosphate_receptor_inhibitor" title="Adenosine diphosphate receptor inhibitor">inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Thienopyridine" title="Thienopyridine">Thienopyridines</a> <ul><li><a href="/wiki/Clopidogrel" title="Clopidogrel">Clopidogrel</a></li> <li><a href="/wiki/Prasugrel" title="Prasugrel">Prasugrel</a></li> <li><a href="/wiki/Ticlopidine" title="Ticlopidine">Ticlopidine</a></li></ul></li> <li><a href="/wiki/Nucleotide" title="Nucleotide">Nucleotide</a>/<a href="/wiki/Nucleoside" title="Nucleoside">nucleoside</a> analogs <ul><li><a href="/wiki/Cangrelor" title="Cangrelor">Cangrelor</a></li> <li><a href="/wiki/Elinogrel" title="Elinogrel">Elinogrel</a></li> <li><a href="/wiki/Ticagrelor" title="Ticagrelor">Ticagrelor</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Prostaglandin_analogue" title="Prostaglandin analogue">Prostaglandin analogue</a> (<a href="/wiki/Prostacyclin" title="Prostacyclin">PGI2</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Beraprost" title="Beraprost">Beraprost</a></li> <li><a href="/wiki/Iloprost" title="Iloprost">Iloprost</a></li> <li><a href="/wiki/Prostacyclin" title="Prostacyclin">Prostacyclin</a></li> <li><a href="/wiki/Treprostinil" title="Treprostinil">Treprostinil</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mechanism_of_action_of_aspirin" title="Mechanism of action of aspirin">COX inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aspirin" title="Aspirin">Acetylsalicylic acid/Aspirin</a><sup>#</sup></li> <li><a href="/wiki/Aloxiprin" title="Aloxiprin">Aloxiprin</a></li> <li><a href="/wiki/Carbasalate_calcium" title="Carbasalate calcium">Carbasalate calcium</a></li> <li><a href="/wiki/Indobufen" title="Indobufen">Indobufen</a></li> <li><a href="/wiki/Triflusal" title="Triflusal">Triflusal</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Thromboxane_inhibitors" class="mw-redirect" title="Thromboxane inhibitors">Thromboxane inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Thromboxane_synthase_inhibitors" class="mw-redirect" title="Thromboxane synthase inhibitors">Thromboxane synthase inhibitors</a> <ul><li><a href="/wiki/Dipyridamole" title="Dipyridamole">Dipyridamole</a> (<a href="/wiki/Acetylsalicylic_acid/dipyridamole" title="Acetylsalicylic acid/dipyridamole">+ aspirin</a>)</li> <li><a href="/wiki/Picotamide" title="Picotamide">Picotamide</a></li> <li><a href="/wiki/Terbogrel" title="Terbogrel">Terbogrel</a></li></ul></li> <li><a href="/wiki/Thromboxane_receptor_antagonist" class="mw-redirect" title="Thromboxane receptor antagonist">Receptor antagonists</a> <ul><li><a href="/wiki/Terbogrel" title="Terbogrel">Terbogrel</a></li> <li><a href="/wiki/Terutroban" title="Terutroban">Terutroban</a><sup>§</sup></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Phosphodiesterase_inhibitor" title="Phosphodiesterase inhibitor">Phosphodiesterase inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cilostazol" title="Cilostazol">Cilostazol</a></li> <li><a href="/wiki/Dipyridamole" title="Dipyridamole">Dipyridamole</a></li> <li><a href="/wiki/Triflusal" title="Triflusal">Triflusal</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cloricromen" title="Cloricromen">Cloricromen</a></li> <li><a href="/wiki/Ditazole" title="Ditazole">Ditazole</a></li> <li><a href="/wiki/Vorapaxar" title="Vorapaxar">Vorapaxar</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Anticoagulant" title="Anticoagulant">Anticoagulants</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Vitamin_K_antagonist" title="Vitamin K antagonist">Vitamin K antagonists</a><br />(inhibit <a href="/wiki/Thrombin" title="Thrombin">II</a>, <a href="/wiki/Factor_VII" title="Factor VII">VII</a>, <a href="/wiki/Factor_IX" title="Factor IX">IX</a>, <a href="/wiki/Factor_X" title="Factor X">X</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Coumarin" title="Coumarin">Coumarins</a>: <a href="/wiki/Acenocoumarol" title="Acenocoumarol">Acenocoumarol</a></li> <li><a href="/wiki/Coumatetralyl" title="Coumatetralyl">Coumatetralyl</a></li> <li><a href="/wiki/Dicoumarol" title="Dicoumarol">Dicoumarol</a></li> <li><a href="/wiki/Ethyl_biscoumacetate" title="Ethyl biscoumacetate">Ethyl biscoumacetate</a></li> <li><a href="/wiki/Phenprocoumon" title="Phenprocoumon">Phenprocoumon</a></li> <li><a href="/wiki/Warfarin" title="Warfarin">Warfarin</a><sup>#</sup></li> <li><a href="/wiki/1,3-Indandione" title="1,3-Indandione">1,3-Indandiones</a>: <a href="/wiki/Clorindione" title="Clorindione">Clorindione</a></li> <li><a href="/wiki/Diphenadione" title="Diphenadione">Diphenadione</a></li> <li><a href="/wiki/Phenindione" title="Phenindione">Phenindione</a></li> <li>Other: <a href="/wiki/Tioclomarol" title="Tioclomarol">Tioclomarol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Factor_Xa" class="mw-redirect" title="Factor Xa">Factor Xa</a> inhibitors<br />(with some II inhibition)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Heparin" title="Heparin">Heparin</a> group/<br /><a href="/wiki/Glycosaminoglycan" title="Glycosaminoglycan">glycosaminoglycans</a>/<br />(bind <a href="/wiki/Antithrombin" title="Antithrombin">antithrombin</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Low-molecular-weight_heparin" title="Low-molecular-weight heparin">Low-molecular-weight heparin</a> <ul><li><a href="/wiki/Bemiparin_sodium" title="Bemiparin sodium">Bemiparin</a></li> <li><a href="/wiki/Certoparin_sodium" title="Certoparin sodium">Certoparin</a></li> <li><a href="/wiki/Dalteparin_sodium" title="Dalteparin sodium">Dalteparin</a></li> <li><a href="/wiki/Enoxaparin_sodium" title="Enoxaparin sodium">Enoxaparin</a></li> <li><a href="/wiki/Nadroparin_calcium" title="Nadroparin calcium">Nadroparin</a></li> <li><a href="/wiki/Parnaparin_sodium" title="Parnaparin sodium">Parnaparin</a></li> <li><a href="/wiki/Reviparin_sodium" title="Reviparin sodium">Reviparin</a></li> <li><a href="/wiki/Tinzaparin_sodium" title="Tinzaparin sodium">Tinzaparin</a></li></ul></li> <li><a href="/wiki/Oligosaccharide" title="Oligosaccharide">Oligosaccharides</a> <ul><li><a href="/wiki/Fondaparinux" title="Fondaparinux">Fondaparinux</a></li> <li><a href="/wiki/Idraparinux" title="Idraparinux">Idraparinux</a><sup>§</sup></li></ul></li> <li><a href="/wiki/Heparinoid" title="Heparinoid">Heparinoids</a> <ul><li><a href="/wiki/Danaparoid" title="Danaparoid">Danaparoid</a></li> <li><a href="/wiki/Dermatan_sulfate" title="Dermatan sulfate">Dermatan sulfate</a></li> <li><a href="/wiki/Sulodexide" title="Sulodexide">Sulodexide</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Direct_factor_Xa_inhibitors" title="Direct factor Xa inhibitors">Direct Xa inhibitors</a> ("xabans")</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Apixaban" title="Apixaban">Apixaban</a></li> <li><a class="mw-selflink selflink">Betrixaban</a></li> <li><a href="/wiki/Darexaban" title="Darexaban">Darexaban</a><sup>§</sup></li> <li><a href="/wiki/Edoxaban" title="Edoxaban">Edoxaban</a></li> <li><a href="/wiki/Otamixaban" title="Otamixaban">Otamixaban</a><sup>§</sup></li> <li><a href="/wiki/Rivaroxaban" title="Rivaroxaban">Rivaroxaban</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Direct_thrombin_inhibitor" title="Direct thrombin inhibitor">Direct thrombin (IIa) inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Direct_thrombin_inhibitor#Bivalent" title="Direct thrombin inhibitor">Bivalent</a>: <a href="/wiki/Hirudin" title="Hirudin">Hirudin</a> <ul><li><a href="/wiki/Bivalirudin" title="Bivalirudin">Bivalirudin</a></li> <li><a href="/wiki/Desirudin" class="mw-redirect" title="Desirudin">Desirudin</a></li> <li><a href="/wiki/Lepirudin" title="Lepirudin">Lepirudin</a><sup>‡</sup></li></ul></li> <li><a href="/wiki/Direct_thrombin_inhibitor#Univalent" title="Direct thrombin inhibitor">Univalent</a>: <a href="/wiki/Argatroban" title="Argatroban">Argatroban</a></li> <li><a href="/wiki/Dabigatran" title="Dabigatran">Dabigatran</a></li> <li><a href="/w/index.php?title=Efegatran&action=edit&redlink=1" class="new" title="Efegatran (page does not exist)">Efegatran</a></li> <li><a href="/wiki/Inogatran" title="Inogatran">Inogatran</a><sup>§</sup></li> <li><a href="/wiki/Melagatran" class="mw-redirect" title="Melagatran">Melagatran</a><sup>‡</sup></li> <li><a href="/wiki/Ximelagatran" title="Ximelagatran">Ximelagatran</a><sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Abelacimab" title="Abelacimab">Abelacimab</a></li> <li><a href="/wiki/Antithrombin" title="Antithrombin">Antithrombin III</a></li> <li><a href="/wiki/Defibrotide" title="Defibrotide">Defibrotide</a></li> <li><a href="/wiki/Nafamostat" title="Nafamostat">Nafamostat</a></li> <li><a href="/wiki/Protein_C" title="Protein C">Protein C</a> <ul><li><a href="/wiki/Drotrecogin_alfa" title="Drotrecogin alfa">Drotrecogin alfa</a><sup>‡</sup></li></ul></li> <li><a href="/wiki/Ramatroban" title="Ramatroban">Ramatroban</a></li> <li><a href="/wiki/REG1" title="REG1">REG1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Thrombolytic_drug" class="mw-redirect" title="Thrombolytic drug">Thrombolytic drugs</a>/<br /><a href="/wiki/Fibrinolytic" class="mw-redirect" title="Fibrinolytic">fibrinolytics</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Plasminogen_activator" title="Plasminogen activator">Plasminogen activators</a>: <a href="/wiki/Recombinant_tissue_plasminogen_activators" class="mw-redirect" title="Recombinant tissue plasminogen activators">r-tPA</a> <ul><li><a href="/wiki/Alteplase" title="Alteplase">Alteplase</a><sup>#</sup></li> <li><a href="/wiki/Reteplase" title="Reteplase">Reteplase</a></li> <li><a href="/wiki/Tenecteplase" title="Tenecteplase">Tenecteplase</a></li> <li><a href="/wiki/Desmoteplase" title="Desmoteplase">Desmoteplase</a><sup>†</sup></li></ul></li> <li>UPA <ul><li><a href="/wiki/Saruplase" title="Saruplase">Saruplase</a></li> <li><a href="/wiki/Urokinase" title="Urokinase">Urokinase</a></li></ul></li> <li><a href="/wiki/Anistreplase" title="Anistreplase">Anistreplase</a></li> <li><a href="/wiki/Monteplase" title="Monteplase">Monteplase</a></li> <li><a href="/wiki/Streptokinase" title="Streptokinase">Streptokinase</a><sup>#</sup></li> <li>Other <a href="/wiki/Serine_endopeptidase" class="mw-redirect" title="Serine endopeptidase">serine endopeptidases</a>: <a href="/wiki/Ancrod" title="Ancrod">Ancrod</a><sup>‡</sup></li> <li><a href="/wiki/Brinase" title="Brinase">Brinase</a></li> <li><a href="/wiki/Fibrinolysin" title="Fibrinolysin">Fibrinolysin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Anticoagulant" title="Anticoagulant">Non-medicinal</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Citrate" class="mw-redirect" title="Citrate">Citrate</a></li> <li><a href="/wiki/Ethylenediaminetetraacetic_acid" title="Ethylenediaminetetraacetic acid">EDTA</a></li> <li><a href="/wiki/Oxalate" title="Oxalate">Oxalate</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background: transparent; padding: 0px;"><div><div class="hlist"> <ul><li><sup>#</sup><a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li> <li><sup>‡</sup><a href="/wiki/List_of_withdrawn_drugs" title="List of withdrawn drugs">Withdrawn</a> from market</li> <li><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a>: <ul><li><sup>†</sup><a href="/wiki/Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li> <li><sup>§</sup>Never to phase III</li></ul></li></ul> </div></div></td></tr></tbody></table></div> <p><br /> </p> <style data-mw-deduplicate="TemplateStyles:r1012311289">.mw-parser-output .asbox{position:relative;overflow:hidden}.mw-parser-output .asbox table{background:transparent}.mw-parser-output .asbox p{margin:0}.mw-parser-output .asbox p+p{margin-top:0.25em}.mw-parser-output .asbox-body{font-style:italic}.mw-parser-output .asbox-note{font-size:smaller}.mw-parser-output .asbox .navbar{position:absolute;top:-0.75em;right:1em;display:none}</style><div role="note" class="metadata plainlinks asbox stub"><table role="presentation"><tbody><tr class="noresize"><td><span typeof="mw:File"><a href="/wiki/File:Warfarin-from-xtal-3D-vdW.png" class="mw-file-description"><img alt="Stub icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/cd/Warfarin-from-xtal-3D-vdW.png/40px-Warfarin-from-xtal-3D-vdW.png" decoding="async" width="40" height="30" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/cd/Warfarin-from-xtal-3D-vdW.png/60px-Warfarin-from-xtal-3D-vdW.png 1.5x, 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