MetaCyc

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style='flex:5'> <SCRIPT type='text/javascript'>  </SCRIPT> <center class='header pageTitle' role='heading' aria-level='1'><a href="/META/organism-summary" class="ORGANISM-ORGKB"><i>MetaCyc</i> </a> EC 2.7.1.171 -- protein-fructosamine 3-kinase</center> </div> </div> <p class=ecoparagraph> <table role=presentation><tr><td style="text-align:left;vertical-align:top;border:0">Parent Class: </td><td style="text-align:left;vertical-align:top;border:0"><a href="/META/NEW-IMAGE?type=EC-NUMBER&object=EC-Numbers" class="EC-NUMBER">EC-Numbers</a> → <a href="/META/NEW-IMAGE?type=EC-NUMBER&object=EC-2" class="EC-NUMBER">2 -- Transferases</a> → <a href="/META/NEW-IMAGE?type=EC-NUMBER&object=EC-2.7" class="EC-NUMBER">2.7 -- Transferring phosphorous-containing groups</a> → <a href="/META/NEW-IMAGE?type=EC-NUMBER&object=EC-2.7.1" class="EC-NUMBER">2.7.1 -- Phosphotransferases with an alcohol group as acceptor</a></td></tr></table> </p> <p class=ecoparagraph> Synonyms: FN3K, fructosamine 3-kinase </p> <p class=ecoparagraph> Systematic Name: ATP:[protein]-<em>N</em><small><sup>6</sup></small>-<small>D</small>-fructosyl-<small>L</small>-lysine 3-phosphotransferase </p> <p class=ecoparagraph> Unification Links: <a href="http://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.171" class="LINK">BRENDA:2.7.1.171</a>, <a href="https://enzyme.expasy.org/EC/2.7.1.171" class="LINK">ENZYME:2.7.1.171</a>, <a href="http://www.enzyme-database.org/query.php?ec=2.7.1.171" class="LINK">IUBMB-ExplorEnz:2.7.1.171</a> </p> <p class=ecoparagraph> Reaction: <br> <a href="/reaction?orgid=META&id=RXN-12005" class="REACTION" data-tippy-content='<b>Reaction:</b> EC 2.7.1.171 <b>ID:</b> RXN-12005<br>a [protein]-<i>N</i><sup>6</sup>-(1-deoxy-D-fructos-1-yl)-L-lysine + ATP → a [protein]-<i>N</i><sup>6</sup>-(1-deoxy-3-<i>O</i>-phospho-D-fructos-1-yl)-L-lysine + ADP + H<SUP>+</SUP><br> <b>Enzyme:</b> fructosamine-3-kinase FN3K'>a [protein]-<i>N</i><sup>6</sup>-(1-deoxy-D-fructos-1-yl)-L-lysine + ATP → a [protein]-<i>N</i><sup>6</sup>-(1-deoxy-3-<i>O</i>-phospho-D-fructos-1-yl)-L-lysine + ADP + H<SUP>+</SUP></a> </p> <p class=ecoparagraph> Enzymes and Genes: <br> <a href="/gene?orgid=META&id=ENSG00000167363-MONOMER" class="ENZYME" data-tippy-content=' <b>Enzyme:</b> fructosamine-3-kinase<br><b>ID:</b> ENSG00000167363-MONOMER<br> <b>Species:</b> <i>Homo sapiens</i><br> <b>Evidence:</b> Assay of protein purified to homogeneity from its native host [Szwergold01]'>fructosamine-3-kinase</a>: <a href="/gene?orgid=META&id=HS09549" class="GENE" data-tippy-content=' <b>Gene:</b> FN3K HS09549<br> <b>Location:</b> 83,669,366 -> 83,684,564 <br> <b>Product:</b> fructosamine-3-kinase<br> <b>Species:</b> <i>Homo sapiens</i>'>FN3K</a> ( <a href="/META/NEW-IMAGE?object=TAX-9606" class="ORGANISM" data-tippy-content='<b><i>Homo sapiens</i></b><br>NCBI Taxonomy ID: <b>9606</b><br>Rank: <b>species</b><br>Lineage:<br> cellular organisms<br> Eukaryota<br> Opisthokonta<br> Metazoa<br> Eumetazoa<br> Bilateria<br> Deuterostomia<br> Chordata<br> Craniata <chordates><br> Vertebrata <vertebrates><br> Gnathostomata <vertebrates><br> Teleostomi<br> Euteleostomi<br> Sarcopterygii<br> Dipnotetrapodomorpha<br> Tetrapoda<br> Amniota<br> Mammalia<br> Theria <mammals><br> Eutheria<br> Boreoeutheria<br> Euarchontoglires<br> Primates<br> Haplorrhini<br> Simiiformes<br> Catarrhini<br> Hominoidea<br> Hominidae<br> Homininae<br> Homo'>Homo sapiens </a>) </p> <p class=ecoparagraph> Summary: <br> Nonenzymatic glycation is an important factor in the pathogenesis of diabetic complications. Key early intermediates in this process are fructosamines, such as [protein]-N6-D-fructosyl-L-lysine. Fructosamine-3-kinase is part of an ATP-dependent system for removing carbohydrates from nonenzymatically glycated proteins. The phosphorylation destablilizes the [protein]-N6-D-fructosyl-L-lysine adduct and leads to its spontaneous decomposition. </p> <p class=ecoparagraph> Citations: [<a href="http://www.ncbi.nlm.nih.gov/pubmed/11016445" class="CITATION-REFERENCE" data-tippy-content=' Delpierre G, Rider MH, Collard F, Stroobant V, Vanstapel F, Santos H, Van Schaftingen E (2000). <strong>"Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase."</strong> Diabetes 49(10);1627-34. PMID: 11016445'>Delpierre00</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/11522682" class="CITATION-REFERENCE" data-tippy-content=' Szwergold BS, Howell S, Beisswenger PJ (2001). <strong>"Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo."</strong> Diabetes 50(9);2139-47. PMID: 11522682'>Szwergold01</a>] </p> <hr> <p class=ecoparagraph> <h3>References </h3> </p> <p class='ecoparagraph reference'> <a href="http://www.ncbi.nlm.nih.gov/pubmed/11016445" class="CITATION-FRAME" data-tippy-content='PubMed: 11016445'> <span class='key'>Delpierre00</span>: Delpierre G, Rider MH, Collard F, Stroobant V, Vanstapel F, Santos H, Van Schaftingen E (2000). <strong>"Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase."</strong> Diabetes 49(10);1627-34. PMID: 11016445</a><p class='ecoparagraph reference'> <a href="http://www.ncbi.nlm.nih.gov/pubmed/11522682" class="CITATION-FRAME" data-tippy-content='PubMed: 11522682'> <span class='key'>Szwergold01</span>: Szwergold BS, Howell S, Beisswenger PJ (2001). <strong>"Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo."</strong> Diabetes 50(9);2139-47. 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for constraint 1'> <option value=false selected>Select Property</option> </select> <select id="mmdConstraint0" onChange='updateMetadataSlot(0, "m")' aria-label='Operator for constraint 1'> <option value="c" selected>is</option> <option value="nc">is not</option> <option value="a">has any value</option> <option value="n">has no value</option> </select> <div id="mkeywordInput0" style="display:none" class="flexRow"> <select id="mmdKeywordOp0" onchange="updateForOp(0, 'mmdKeywordOp0', 'mmdSubstringAC0', 'm')" aria-label='Operator for constraint 1'> <option value="enum" selected>Exact Match</option> <option value="substr">Substring Match</option> </select> <div class = "mdSubstringInput" id="mmdSubstringAC0"> <input id="mmdKeyword0" type="text" aria-label='Value for constraint 1'> <div id="mmdKWContainer0"></div> </div> </div> <div id="mnumericInput0" style="display:none" class="flexRow"> <select id="mmdNumOp0" onchange="updateForOp(0, 'mmdNumOp0', 'mmdNum0', 'm')" aria-label='Numeric operator for constraint 1'> <option value="e" selected>= (approx.)</option> <option value="lt"><</option> <option value="lte">≤</option> <option value="gt">></option> <option value="gte">≥</option> <option value="enum">Select Values</option> </select> <input id="mmdNum0" type="text" aria-label='Value for constraint 1'> </div> <div id="mmdEnumContainer0" style="display:none"> <select id="mmdEnum0" multiple aria-label='Value for constraint 1'> </select> </div> </div> <div id="mclause1" style="display:none"> <select id="mconnector1" aria-label='Connector for constraint 2'> <option value='AND' selected>AND</option> <option value='OR'>OR</option> </select> <input id="mmdDelete1" type="button" value ="Remove Constraint" onclick='mdRemoveClause(1, "m")' aria-label='Remove Constraint 2'> <br> <div class="flexRowWrap"> <select id="mmdSlot1" onChange='updateMetadataSlot(1, "m")' aria-label='Property for constraint 2'> <option value=false selected>Select Property</option> </select> <select id="mmdConstraint1" onChange='updateMetadataSlot(1, "m")' aria-label='Operator for constraint 2'> <option value="c" selected>is</option> <option value="nc">is not</option> <option value="a">has any value</option> <option value="n">has no value</option> </select> <div id="mkeywordInput1" style="display:none" class="flexRow"> <select id="mmdKeywordOp1" onchange="updateForOp(1, 'mmdKeywordOp1', 'mmdSubstringAC1', 'm')" aria-label='Operator for constraint 2'> <option value="enum" selected>Exact Match</option> <option value="substr">Substring Match</option> </select> <div class = "mdSubstringInput" id="mmdSubstringAC1"> <input id="mmdKeyword1" type="text" aria-label='Value for constraint 2'> <div id="mmdKWContainer1"></div> </div> </div> <div id="mnumericInput1" style="display:none" class="flexRow"> <select id="mmdNumOp1" onchange="updateForOp(1, 'mmdNumOp1', 'mmdNum1', 'm')" aria-label='Numeric operator for constraint 2'> <option value="e" selected>= (approx.)</option> <option 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constraint 3'> <option value="c" selected>is</option> <option value="nc">is not</option> <option value="a">has any value</option> <option value="n">has no value</option> </select> <div id="mkeywordInput2" style="display:none" class="flexRow"> <select id="mmdKeywordOp2" onchange="updateForOp(2, 'mmdKeywordOp2', 'mmdSubstringAC', 'm')" aria-label='Operator for constraint 3'> <option value="enum" selected>Exact Match</option> <option value="substr">Substring Match</option> </select> <div class = "mdSubstringInput" id="mmdSubstringAC2"> <input id="mmdKeyword2" type="text" aria-label='Value for constraint 3'> <div id="mmdKWContainer2"></div> </div> </div> <div id="mnumericInput2" style="display:none" class="flexRow"> <select id="mmdNumOp2" onchange="updateForOp(2, 'mmdNumOp2', 'mmdNum2', 'm')" aria-label='Numeric operator for constraint 3'> <option value="e" selected>= (approx.)</option> <option value="lt"><</option> <option value="lte">≤</option> <option value="gt">></option> <option 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<option value="a">has any value</option> <option value="n">has no value</option> </select> <div id="mkeywordInput3" style="display:none" class="flexRow"> <select id="mmdKeywordOp3" onchange="updateForOp(3, 'mmdKeywordOp3', 'mmdSubstringAC3', 'm')" aria-label='Operator for constraint 4'> <option value="enum" selected>Exact Match</option> <option value="substr">Substring Match</option> </select> <div class = "mdSubstringInput" id="mmdSubstringAC3"> <input id="mmdKeyword3" type="text" aria-label='Value for constraint 4'> <div id="mmdKWContainer3"></div> </div> </div> <div id="mnumericInput3" style="display:none" class="flexRow"> <select id="mmdNumOp3" onchange="updateForOp(3, 'mmdNumOp3', 'mmdNum3', 'm')" aria-label='Numeric operator for constraint 4'> <option value="e" selected>= (approx.)</option> <option value="lt"><</option> <option value="lte">≤</option> <option value="gt">></option> <option value="gte">≥</option> <option value="enum">Select Values</option> </select> <input id="mmdNum3" type="text" aria-label='Value for constraint 4'> </div> <div id="mmdEnumContainer3" style="display:none"> <select id="mmdEnum3" multiple aria-label='Value for constraint 4'> </select> </div> </div> </div> <div id="mclause4" style="display:none"> <select id="mconnector4" aria-label='Connector for constraint 5'> <option value='and' selected>AND</option> <option value='or'>OR</option> </select> <input id="mmdDelete4" type="button" value = "Remove Constraint" onclick='mdRemoveClause(4, "m")' aria-label='Remove Constraint 5'> <br> <div class="flexRowWrap"> <select id="mmdSlot4" onChange='updateMetadataSlot(4, "m")' aria-label='Property for constraint 5'> <option value=false selected>Select Property</option> </select> <select id="mmdConstraint4" onChange='updateMetadataSlot(4, "m")' aria-label='Operator for constraint 5'> <option value="c" selected>is</option> <option value="nc">is not</option> <option value="a">has any value</option> <option value="n">has no value</option> </select> <div id="mkeywordInput4" style="display:none" class="flexRow"> <select id="mmdKeywordOp4" onchange="updateForOp(4, 'mmdKeywordOp4', 'mmdSubstringAC4', 'm')" aria-label='Operator for constraint 5'> <option value="enum" selected>Exact Match</option> <option value="substr">Substring Match</option> </select> <div class = "mdSubstringInput" id="mmdSubstringAC4"> <input id="mmdKeyword4" type="text" aria-label='Value for constraint 5'> <div id="mmdKWContainer4"></div> </div> </div> <div id="mnumericInput4" style="display:none"> <select id="mmdNumOp4" onchange="updateForOp(4, 'mmdNumOp4', 'mmdNum4', 'm')" aria-label='Numeric operator for constraint 5'> <option value="e" selected>= (approx.)</option> <option value="lt"><</option> <option value="lte">≤</option> <option value="gt">></option> <option value="gte">≥</option> <option value="enum">Select Values</option> </select> <input id="mmdNum4" type="text" aria-label='Value for constraint 5'> </div> <div id="mmdEnumContainer4" style="display:none"> <select id="mmdEnum4" multiple aria-label='Value for constraint 5'> </select> </div> </div> </div> <div id="mclause5" style="display:none"> <select id="mconnector5" aria-label='Connector for constraint 6'> <option value='and' selected>AND</option> <option value='or'>OR</option> </select> <input id="mmdDelete5" type="button" value="Remove Constraint" onclick='mdRemoveClause(5, "m")' aria-label='Remove Constraint 6'> <br> <div class="flexRowWrap"> <select id="mmdSlot5" onChange='updateMetadataSlot(5, "m")' aria-label='Property for constraint 6'> <option value=false selected>Select Property</option> </select> <select id="mmdConstraint5" onChange='updateMetadataSlot(5, "m")' aria-label='Operator for constraint 6'> <option value="c" selected>is</option> <option value="nc">is not</option> <option value="a">has any value</option> <option value="n">has no value</option> </select> <div id="mkeywordInput5" style="display:none" class="flexRow"> <select id="mmdKeywordOp5" onchange="updateForOp(5, 'mmdKeywordOp5', 'mmdSubstringAC5', 'm')" aria-label='Operator for constraint 6'> <option value="enum" selected>Exact Match</option> <option value="substr">Substring Match</option> </select> <div class = "mdSubstringInput" id="mmdSubstringAC5"> <input id="mmdKeyword5" type="text" aria-label='Value for constraint 6'> <div id="mmdKWContainer5"></div> </div> </div> <div id="mnumericInput5" style="display:none" class="flexRow"> <select id="mmdNumOp5" onchange="updateForOp(5, 'mmdNumOp5', 'mmdNum5', 'm')" aria-label='Numeric operator for constraint 6'> <option value="e" selected>= (approx.)</option> <option value="lt"><</option> <option value="lte">≤</option> <option value="gt">></option> <option value="gte">≥</option> <option value="enum">Select Values</option> </select> <input id="mmdNum5" type="text" aria-label='Value for constraint 6'> </div> <div id="mmdEnumContainer5" style="display:none"> <select id="mmdEnum5" multiple aria-label='Value for constraint 6'> </select> </div> </div> </div> <br> <div class="flexRow"> <input id="maddClause" type="button" value = "Add Constraint" onclick='mdAddClause("m")' style="display:none"> <input id="mmdSearch" type="button" value = "Find Organisms" onclick = 'processMdQuery(true, "m")'> </div> <div id="mmdResults" class='yui3-skin-sam'></div> </div> <div id="multiorgSavedTab" class='multiorgselectorTab' style="overflow-y:auto"> <div style="padding-bottom:20px"> <span>Database lists include both predefined lists and lists that are saved as SmartTables that you can edit from your <a href="/smarttables" target="new.window">My SmartTables</a> page. To add all organisms from a saved list, check the box next to the list name and then click the "Add" button. </span> </div> <div id="multiorgSavedTree" class="ygtv-checkbox"></div> <div class="requiresLogin" style="padding-top:50px"> <span class="requiresNoSavedOrglist requiresLogin"> You have no saved database lists </span> </div> <div class="requiresNotLoggedIn" style="padding-top:50px"> Log in and reload this page to access your saved database lists. </div> </div> </div> <div id="tierKey" style="padding-top:3px"> <span class="tier1">Tier 1</span> and <span class="tier2">Tier 2</span> databases are displayed with orange and blue backgrounds, respectively. </div> </div> <div class='buttons flexCol' style="gap:4px;margin:3px;"> <div id="multiorgSelectAllRow"> <input type="button" id="multiorgSelectAllBtn" class="disableWhenAllSelected" value="Select All" onclick="multiorgSelectAll()"> </div> <input type="button" id="multiorgAddToList" class="disableWhenAllSelected" value="Add →" onclick="addNewSelections()"> <input type="button" id="multiorgDeleteFromList" class="disableWhenAllSelected" value="Remove ←" onclick="deleteMultiorgOptions(false)"> <input type="button" id="multiorgClearAll" value="Clear All" onclick="deleteMultiorgOptions(true)"> </div> <div> <label for="multiorgSelection"><h3>Current Selection</h3></label> <span id="multiNumSelected">0</span> databases or taxa currently selected. <p> <div id='multiorgSelectionDiv'> <select multiple id="multiorgSelection"> </select> </div> <div class="requiresLogin" id="rememberAsST"> <fieldset style="border:none;padding:0"> <legend style="padding-top:3px"> Remember Selection as SmartTable:</legend> <label> <input type="radio" name="stSave" value="new" checked> Create New </label> <label> <input type="radio" name="stSave" value="old"> Update Existing </label> <div style="padding-top:3px"> <input type="text" id="orglistname" style="width:200px" placeholder="Enter SmartTable Name"> <select id="savedOrglistUpdate" class="savedOrglistSelectEl" aria-label="Select an organism SmartTable to update" style="display:none"> </select> <input type="button" value="Save" title="Clicking this button will save or update the specified organism SmartTable to refer to the currently selected databases. It will not close this dialog or submit your choices. If no databases are currently selected, clicking this button will cause the named SmartTable to be deleted. SmartTables saved here can be accessed from the My Lists tab."> </div> </fieldset> </div> <div class="requiresNotLoggedIn" style="padding-top:3px"> Note: if you create a user account and log in, you can save your database lists for next time. </div> </div> </div> </form> </div> </div> <script type="text/javascript"> multiorg_maxOrgs = 70 </script>  <script type="text/javascript"> if (forceOrgID && forceOrgID != "DEFAULT") setOrganism(forceOrgID); </script> <script src="https://unpkg.com/@popperjs/core@2"></script> <script src="https://unpkg.com/tippy.js@6"></script> <script> /* following relates to tooltips for template-top-menubar */ var subTipContent; subTipContent = "You are not connected to a paid subscription, which limits your access to BioCyc. The EcoCyc database is free."; var accelTipContent = "Create a free account to access SmartTables, run metabolic models, customize appearance, and more." if (subTipContent) { tippy('#subscribe', { content: subTipContent, theme: 'biocyc', placement: 'bottom', plugins: [hideOnEsc] }); } tippy('#account', { content: accelTipContent, theme: 'biocyc', placement: 'bottom', plugins: [hideOnEsc] }); /* following relates to tooltip for MetaCyc */ tippy('#metacycRef', { theme: 'biocyc', content: "MetaCyc is a curated database of metabolic enzymes and pathways from all domains of life.", placement: 'right', plugins: [hideOnEsc] }); </script> </BODY> </HTML>

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