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class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" alt="Luisa Consuelo Rubiano Perea" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/52283790/14202204/19677946/s200_luisa_consuelo.rubiano_perea.jpg" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Luisa Consuelo Rubiano Perea</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://javerianacali.academia.edu/">Pontificia Universidad Javeriana, Cali</a>, <a class="u-tcGrayDarker" href="https://javerianacali.academia.edu/Departments/Salud_P%C3%BAblica_y_Epidemiolog%C3%ADa/Documents">Salud Pública y Epidemiología</a>, <span class="u-tcGrayDarker">Faculty Member</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Luisa Consuelo" data-follow-user-id="52283790" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="52283790"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">19</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">6</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">3</p></div></a><a href="/LRubianoPerea/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data">1</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Luisa Consuelo Rubiano Perea</h3></div><div class="js-work-strip profile--work_container" data-work-id="97485598"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/97485598/Protocolo_para_la_evaluaci%C3%B3n_fisioterap%C3%A9utica_inicial_y_final_de_pacientes_ambulatorios_que_ingresan_a_programas_de_rehabilitaci%C3%B3n_cardiaca_fase_II"><img alt="Research paper thumbnail of Protocolo para la evaluación fisioterapéutica inicial y final de pacientes ambulatorios que ingresan a programas de rehabilitación cardiaca fase II" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/97485598/Protocolo_para_la_evaluaci%C3%B3n_fisioterap%C3%A9utica_inicial_y_final_de_pacientes_ambulatorios_que_ingresan_a_programas_de_rehabilitaci%C3%B3n_cardiaca_fase_II">Protocolo para la evaluación fisioterapéutica inicial y final de pacientes ambulatorios que ingresan a programas de rehabilitación cardiaca fase II</a></div><div class="wp-workCard_item"><span>Universidad Colegio Mayor Nuestra Senora Del Rosario Universidad Del Rosario Edocur Repositorio Institucional Disponible En Http Repository Urosario Edu Co</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action 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Fe2O3 nanoparticles" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94191004/CO_oxidation_at_20_C_over_Au_SBA_15_catalysts_decorated_by_Fe2O3_nanoparticles">CO oxidation at 20 °C over Au/SBA-15 catalysts decorated by Fe2O3 nanoparticles</a></div><div class="wp-workCard_item"><span>Catalysis Communications</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This contribution describes the effect of SBA-15 substrate modification with variable amounts of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This contribution describes the effect of SBA-15 substrate modification with variable amounts of Fe2O3 (5, 10, 15 and 20wt.%) on the catalytic response of supported gold catalysts in CO oxidation at 20°C. Catalytic activity was found to increase with the Fe2O3 loading even though this increase was not linear: the highest catalytic activity was observed for the catalyst loaded with</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94191004"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94191004"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94191004; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94191004]").text(description); $(".js-view-count[data-work-id=94191004]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94191004; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94191004']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94191004, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=94191004]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94191004,"title":"CO oxidation at 20 °C over Au/SBA-15 catalysts decorated by Fe2O3 nanoparticles","translated_title":"","metadata":{"abstract":"This contribution describes the effect of SBA-15 substrate modification with variable amounts of Fe2O3 (5, 10, 15 and 20wt.%) on the catalytic response of supported gold catalysts in CO oxidation at 20°C. 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Colombia busca estandarizar la atención en centros especializados, bajo las recomendaciones de la Guía de Práctica Clínica vigente y con una intervención multidisciplinaria. Objetivo: Determinar el cumplimiento de los indicadores de gestión en un programa para el manejo de pacientes que viven con VIH/SIDA, en una IPS especializada de Cali, Colombia. Métodos: Se hizo un estudio observacional, descriptivo y retrospectivo en pacientes mayores de 18 años que ingresaron al programa e iniciaron tratamiento antirretroviral, entre enero y diciembre de 2016. Se analizó información de 173 registros clínicos y datos reportados en la Cuenta de Alto Costo de pacientes con diagnóstico de VIH/SIDA. Se evaluaron 13 indicadores del área clínica, todos de proceso; tres de evaluación inicial, dos de monitoreo, seis de terapia y dos de prevención especifica.Resultad...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c6f5f75941539423b1735ef4b267e544" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89660796,"asset_id":84743589,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89660796/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="84743589"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="84743589"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 84743589; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=84743589]").text(description); $(".js-view-count[data-work-id=84743589]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 84743589; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='84743589']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 84743589, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c6f5f75941539423b1735ef4b267e544" } } $('.js-work-strip[data-work-id=84743589]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":84743589,"title":"Cumplimiento de los indicadores de proceso en un programa para el manejo de pacientes que viven con VIH/SIDA","translated_title":"","metadata":{"abstract":"Introducción: La infección por VIH/SIDA es un problema de salud pública para el cual se han desarrollado múltiples estrategias de control. Colombia busca estandarizar la atención en centros especializados, bajo las recomendaciones de la Guía de Práctica Clínica vigente y con una intervención multidisciplinaria. Objetivo: Determinar el cumplimiento de los indicadores de gestión en un programa para el manejo de pacientes que viven con VIH/SIDA, en una IPS especializada de Cali, Colombia. Métodos: Se hizo un estudio observacional, descriptivo y retrospectivo en pacientes mayores de 18 años que ingresaron al programa e iniciaron tratamiento antirretroviral, entre enero y diciembre de 2016. Se analizó información de 173 registros clínicos y datos reportados en la Cuenta de Alto Costo de pacientes con diagnóstico de VIH/SIDA. 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Métodos: Se hizo un estudio observacional, descriptivo y retrospectivo en pacientes mayores de 18 años que ingresaron al programa e iniciaron tratamiento antirretroviral, entre enero y diciembre de 2016. Se analizó información de 173 registros clínicos y datos reportados en la Cuenta de Alto Costo de pacientes con diagnóstico de VIH/SIDA. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="84743588"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/84743588/Participatory_Visual_Methods_with_caregivers_of_children_with_Congenital_Zika_Syndrome_in_Colombia_A_case_study"><img alt="Research paper thumbnail of Participatory Visual Methods with caregivers of children with Congenital Zika Syndrome in Colombia: A case study" class="work-thumbnail" src="https://attachments.academia-assets.com/89660794/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/84743588/Participatory_Visual_Methods_with_caregivers_of_children_with_Congenital_Zika_Syndrome_in_Colombia_A_case_study">Participatory Visual Methods with caregivers of children with Congenital Zika Syndrome in Colombia: A case study</a></div><div class="wp-workCard_item"><span>Wellcome Open Research</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: This study explores the acceptability and feasibility of the use of two different Par...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: This study explores the acceptability and feasibility of the use of two different Participatory Visual Methods (Participatory Video and Digital Storytelling) in gathering information on the experiences and perspectives of carers of children with Congenital Zika Syndrome within Colombia. Methods: Participatory Video was used to assess the impact of the Juntos parent-support intervention in the lives of carers, and Digital Storytelling was used to explore the healthcare access for these children. In-depth interviews were conducted to probe participants on their views of these methods. Results: One Participatory Video was produced and four Digital Stories. Of the initial eight caregivers who took part in the Participatory Video process, four completed both the Digital Storytelling process and an in-depth interview about their experiences. The main factors shaping participants’ experiences related to the skills learned in making the videos, the feeling of collectiveness and...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ce35c48a49331d083f01dfb04d0c02cc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89660794,"asset_id":84743588,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89660794/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="84743588"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="84743588"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 84743588; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=84743588]").text(description); $(".js-view-count[data-work-id=84743588]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 84743588; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='84743588']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 84743588, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ce35c48a49331d083f01dfb04d0c02cc" } } $('.js-work-strip[data-work-id=84743588]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":84743588,"title":"Participatory Visual Methods with caregivers of children with Congenital Zika Syndrome in Colombia: A case study","translated_title":"","metadata":{"abstract":"Background: This study explores the acceptability and feasibility of the use of two different Participatory Visual Methods (Participatory Video and Digital Storytelling) in gathering information on the experiences and perspectives of carers of children with Congenital Zika Syndrome within Colombia. Methods: Participatory Video was used to assess the impact of the Juntos parent-support intervention in the lives of carers, and Digital Storytelling was used to explore the healthcare access for these children. In-depth interviews were conducted to probe participants on their views of these methods. Results: One Participatory Video was produced and four Digital Stories. Of the initial eight caregivers who took part in the Participatory Video process, four completed both the Digital Storytelling process and an in-depth interview about their experiences. The main factors shaping participants’ experiences related to the skills learned in making the videos, the feeling of collectiveness and...","publisher":"F1000 Research Ltd","publication_name":"Wellcome Open Research"},"translated_abstract":"Background: This study explores the acceptability and feasibility of the use of two different Participatory Visual Methods (Participatory Video and Digital Storytelling) in gathering information on the experiences and perspectives of carers of children with Congenital Zika Syndrome within Colombia. Methods: Participatory Video was used to assess the impact of the Juntos parent-support intervention in the lives of carers, and Digital Storytelling was used to explore the healthcare access for these children. In-depth interviews were conducted to probe participants on their views of these methods. Results: One Participatory Video was produced and four Digital Stories. Of the initial eight caregivers who took part in the Participatory Video process, four completed both the Digital Storytelling process and an in-depth interview about their experiences. The main factors shaping participants’ experiences related to the skills learned in making the videos, the feeling of collectiveness and...","internal_url":"https://www.academia.edu/84743588/Participatory_Visual_Methods_with_caregivers_of_children_with_Congenital_Zika_Syndrome_in_Colombia_A_case_study","translated_internal_url":"","created_at":"2022-08-14T18:58:48.410-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52283790,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":89660794,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89660794/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/89660794/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Participatory_Visual_Methods_with_caregi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89660794/pdf-libre.pdf?1660529274=\u0026response-content-disposition=attachment%3B+filename%3DParticipatory_Visual_Methods_with_caregi.pdf\u0026Expires=1732779776\u0026Signature=NRYjguCcVIwo8qha5k-o1dYBxD44b1gcK3IqbyOAKWRb0klU1fnWeXTDV-ImX7eMi5gF87eUeZ1Cm20fmj59jeD~yfjvkt0BBcYDAr4dU1lnRWe3BIDvnVDEa~7X-VsZ7pqAAWNQJcu2nsmB7N5L~IJ9oqUMd5UBtki54iOW9tpNKnWMcCs~KqXEYDCYdhrNYEwhe9xqbeggX7SOD3lMsjJ~DUZHSf8UrPop90H2uKKPVMXKgIwl0cXJDTxS-zTx8xeaN~Q-ktKMa4K~l6nVrb4ZFWR-t1cEyZ5KnwK0NdwjZLaN65wMJvjb3ceJcviZPB63YLgJiEq9i588T~ECfw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Participatory_Visual_Methods_with_caregivers_of_children_with_Congenital_Zika_Syndrome_in_Colombia_A_case_study","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":52283790,"first_name":"Luisa Consuelo","middle_initials":"","last_name":"Rubiano Perea","page_name":"LRubianoPerea","domain_name":"javerianacali","created_at":"2016-08-20T06:55:56.486-07:00","display_name":"Luisa Consuelo Rubiano Perea","url":"https://javerianacali.academia.edu/LRubianoPerea"},"attachments":[{"id":89660794,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89660794/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/89660794/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Participatory_Visual_Methods_with_caregi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89660794/pdf-libre.pdf?1660529274=\u0026response-content-disposition=attachment%3B+filename%3DParticipatory_Visual_Methods_with_caregi.pdf\u0026Expires=1732779776\u0026Signature=NRYjguCcVIwo8qha5k-o1dYBxD44b1gcK3IqbyOAKWRb0klU1fnWeXTDV-ImX7eMi5gF87eUeZ1Cm20fmj59jeD~yfjvkt0BBcYDAr4dU1lnRWe3BIDvnVDEa~7X-VsZ7pqAAWNQJcu2nsmB7N5L~IJ9oqUMd5UBtki54iOW9tpNKnWMcCs~KqXEYDCYdhrNYEwhe9xqbeggX7SOD3lMsjJ~DUZHSf8UrPop90H2uKKPVMXKgIwl0cXJDTxS-zTx8xeaN~Q-ktKMa4K~l6nVrb4ZFWR-t1cEyZ5KnwK0NdwjZLaN65wMJvjb3ceJcviZPB63YLgJiEq9i588T~ECfw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":22925563,"url":"https://wellcomeopenresearch.org/articles/7-107/v1/xml"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="84743586"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/84743586/Parasitological_Confirmation_and_Analysis_of_Leishmania_Diversity_in_Asymptomatic_and_Subclinical_Infection_following_Resolution_of_Cutaneous_Leishmaniasis"><img alt="Research paper thumbnail of Parasitological Confirmation and Analysis of Leishmania Diversity in Asymptomatic and Subclinical Infection following Resolution of Cutaneous Leishmaniasis" class="work-thumbnail" src="https://attachments.academia-assets.com/89660808/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/84743586/Parasitological_Confirmation_and_Analysis_of_Leishmania_Diversity_in_Asymptomatic_and_Subclinical_Infection_following_Resolution_of_Cutaneous_Leishmaniasis">Parasitological Confirmation and Analysis of Leishmania Diversity in Asymptomatic and Subclinical Infection following Resolution of Cutaneous Leishmaniasis</a></div><div class="wp-workCard_item"><span>PLoS neglected tropical diseases</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The contribution of individuals with subclinical infection to the transmission and endemicity of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The contribution of individuals with subclinical infection to the transmission and endemicity of cutaneous leishmaniasis (CL) is unknown. Immunological evidence of exposure to Leishmania in residents of endemic areas has been the basis for defining the human population with asymptomatic infection. However, parasitological confirmation of subclinical infection is lacking. We investigated the presence and viability of Leishmania in blood and non-invasive mucosal tissue samples from individuals with immunological evidence of subclinical infection in endemic areas for CL caused by Leishmania (Viannia) in Colombia. Detection of Leishmania kDNA was conducted by PCR-Southern Blot, and parasite viability was confirmed by amplification of parasite 7SLRNA gene transcripts. A molecular tool for genetic diversity analysis of parasite populations causing persistent subclinical infection based on PCR amplification and sequence analysis of an 82bp region between kDNA conserved blocks 1 and 2 was d...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="912c9590dd3393ac442105a19386e4f5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89660808,"asset_id":84743586,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89660808/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="84743586"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="84743586"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 84743586; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=84743586]").text(description); $(".js-view-count[data-work-id=84743586]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 84743586; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='84743586']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 84743586, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "912c9590dd3393ac442105a19386e4f5" } } $('.js-work-strip[data-work-id=84743586]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":84743586,"title":"Parasitological Confirmation and Analysis of Leishmania Diversity in Asymptomatic and Subclinical Infection following Resolution of Cutaneous Leishmaniasis","translated_title":"","metadata":{"abstract":"The contribution of individuals with subclinical infection to the transmission and endemicity of cutaneous leishmaniasis (CL) is unknown. Immunological evidence of exposure to Leishmania in residents of endemic areas has been the basis for defining the human population with asymptomatic infection. However, parasitological confirmation of subclinical infection is lacking. We investigated the presence and viability of Leishmania in blood and non-invasive mucosal tissue samples from individuals with immunological evidence of subclinical infection in endemic areas for CL caused by Leishmania (Viannia) in Colombia. Detection of Leishmania kDNA was conducted by PCR-Southern Blot, and parasite viability was confirmed by amplification of parasite 7SLRNA gene transcripts. A molecular tool for genetic diversity analysis of parasite populations causing persistent subclinical infection based on PCR amplification and sequence analysis of an 82bp region between kDNA conserved blocks 1 and 2 was d...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"PLoS neglected tropical diseases"},"translated_abstract":"The contribution of individuals with subclinical infection to the transmission and endemicity of cutaneous leishmaniasis (CL) is unknown. Immunological evidence of exposure to Leishmania in residents of endemic areas has been the basis for defining the human population with asymptomatic infection. However, parasitological confirmation of subclinical infection is lacking. We investigated the presence and viability of Leishmania in blood and non-invasive mucosal tissue samples from individuals with immunological evidence of subclinical infection in endemic areas for CL caused by Leishmania (Viannia) in Colombia. Detection of Leishmania kDNA was conducted by PCR-Southern Blot, and parasite viability was confirmed by amplification of parasite 7SLRNA gene transcripts. 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data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/84743584/Treatment_Failure_and_Miltefosine_Susceptibility_in_Dermal_Leishmaniasis_Caused_by_Leishmania_Subgenus_Viannia_Species"><img alt="Research paper thumbnail of Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species" class="work-thumbnail" src="https://attachments.academia-assets.com/89660813/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/84743584/Treatment_Failure_and_Miltefosine_Susceptibility_in_Dermal_Leishmaniasis_Caused_by_Leishmania_Subgenus_Viannia_Species">Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species</a></div><div class="wp-workCard_item"><span>Antimicrobial Agents and Chemotherapy</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania (...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania ( Viannia ) species are poorly understood. Prospective evaluation of drug susceptibility of strains isolated from individual patients before drug exposure and at clinical failure allows intrinsic and acquired differences in susceptibility to be discerned and analyzed. To determine whether intrinsic susceptibility or loss of susceptibility to miltefosine contributed to treatment failure, we evaluated the miltefosine susceptibility of intracellular amastigotes and promastigotes of six Leishmania ( Viannia ) braziliensis and six Leishmania ( Viannia ) panamensis strains isolated sequentially, at diagnosis and treatment failure, from two children and four adults ≥55 years old with concurrent conditions. Four patients presented only cutaneous lesions, one had mucosal disease, and one had disseminated mucocutaneous disease. 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Prospective evaluation of drug susceptibility of strains isolated from individual patients before drug exposure and at clinical failure allows intrinsic and acquired differences in susceptibility to be discerned and analyzed. To determine whether intrinsic susceptibility or loss of susceptibility to miltefosine contributed to treatment failure, we evaluated the miltefosine susceptibility of intracellular amastigotes and promastigotes of six Leishmania ( Viannia ) braziliensis and six Leishmania ( Viannia ) panamensis strains isolated sequentially, at diagnosis and treatment failure, from two children and four adults ≥55 years old with concurrent conditions. Four patients presented only cutaneous lesions, one had mucosal disease, and one had disseminated mucocutaneous disease. 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To determine whether intrinsic susceptibility or loss of susceptibility to miltefosine contributed to treatment failure, we evaluated the miltefosine susceptibility of intracellular amastigotes and promastigotes of six Leishmania ( Viannia ) braziliensis and six Leishmania ( Viannia ) panamensis strains isolated sequentially, at diagnosis and treatment failure, from two children and four adults ≥55 years old with concurrent conditions. Four patients presented only cutaneous lesions, one had mucosal disease, and one had disseminated mucocutaneous disease. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="84743552"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/84743552/Noninferiority_of_miltefosine_versus_meglumine_antimoniate_for_cutaneous_leishmaniasis_in_children"><img alt="Research paper thumbnail of Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children" class="work-thumbnail" src="https://attachments.academia-assets.com/89660775/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/84743552/Noninferiority_of_miltefosine_versus_meglumine_antimoniate_for_cutaneous_leishmaniasis_in_children">Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children</a></div><div class="wp-workCard_item"><span>The Journal of infectious diseases</span><span>, Jan 15, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Children have a lower response rate to antimonial drugs and higher elimination rate of antimony (...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Children have a lower response rate to antimonial drugs and higher elimination rate of antimony (Sb) than adults. Oral miltefosine has not been evaluated for pediatric cutaneous leishmaniasis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ae026e22bee04586d1da0244d282058d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89660775,"asset_id":84743552,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89660775/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="84743552"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="84743552"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 84743552; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=84743552]").text(description); $(".js-view-count[data-work-id=84743552]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 84743552; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='84743552']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 84743552, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ae026e22bee04586d1da0244d282058d" } } $('.js-work-strip[data-work-id=84743552]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":84743552,"title":"Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children","translated_title":"","metadata":{"abstract":"Children have a lower response rate to antimonial drugs and higher elimination rate of antimony (Sb) than adults. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="81699188"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81699188/Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine"><img alt="Research paper thumbnail of Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine" class="work-thumbnail" src="https://attachments.academia-assets.com/87653395/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81699188/Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine">Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine</a></div><div class="wp-workCard_item"><span>Expert Review of Vaccines</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="025f41d7a58af3366d4f54095b34d687" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":87653395,"asset_id":81699188,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/87653395/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="81699188"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="81699188"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 81699188; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "025f41d7a58af3366d4f54095b34d687" } } $('.js-work-strip[data-work-id=81699188]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":81699188,"title":"Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine","translated_title":"","metadata":{"publisher":"Informa UK Limited","ai_title_tag":"Immunogenicity and Reactogenicity of DTPw-HB/Hib in Infants","grobid_abstract":"Objective: To evaluate, in an open study, the immunogenicity, safety and reactogenicity of a birth dose of hepatitis B vaccine followed by a three-dose course of diphtheria-tetanus whole-cell pertussis-hepatitis B vaccine, extemporaneously mixed with Haemophilus influenzae b (Hib) vaccine. Methods: At 2, 4 and 6 months of age, a single group of 120 Colombian infants were enrolled in this study to receive a regimen consisting of three doses of the combination vaccine following a dose of hepatitis B vaccine at birth. Results: Seroprotection/vaccine response rates to all vaccine antigens was 98-100% 1 month after completion of the full vaccination course. The vaccine had an acceptable reactogenicity profile and the incidence of reported local and general symptoms decreased with the administration of subsequent vaccine doses. Conclusion: The mixed DTPw-HB/Hib vaccine was safe and well-tolerated, with high immunogenicity against all component antigens. Compared with previous studies, reactogenicity did not increase with the additional dose of hepatitis B vaccine given at birth. The DTPw-HB/Hib combination can be used to provide primary vaccination of infants who have already received a first dose of hepatitis B vaccine at birth.","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Expert Review of Vaccines","grobid_abstract_attachment_id":87653395},"translated_abstract":null,"internal_url":"https://www.academia.edu/81699188/Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine","translated_internal_url":"","created_at":"2022-06-17T06:56:35.615-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52283790,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":87653395,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87653395/thumbnails/1.jpg","file_name":"14760584.1.3.27720220617-1-1c6losp.pdf","download_url":"https://www.academia.edu/attachments/87653395/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Immunogenicity_and_reactogenicity_of_DTP.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87653395/14760584.1.3.27720220617-1-1c6losp-libre.pdf?1655475759=\u0026response-content-disposition=attachment%3B+filename%3DImmunogenicity_and_reactogenicity_of_DTP.pdf\u0026Expires=1732779776\u0026Signature=ISJQn59Lal1BZDPTKcOhYc~kVuUUI4GM61nQT4gdG1UzNZ3ARaMxyr6sXoFam8Cj2OA-VF9Rj01a9qFwJ~fPvEhjNfKe6mFTg6Ff0dSx-CS5f2jG62flfZOPIPnFblZcRbhA1C~qzOu6qvJta6zVeid9qn1VucP1inbmW5D-AmMICSe9W6lbEMkQdHmKP98NJ1qgtRjTjf4z2vYJdm8s-a2LfpepLaNN30IrvgXpW3a0noy-IZgFdcWygc5Mixs3q3ZS1Qwdteg5ONulzIxU8hG0zLTdEV0PTAu3p3O~84J2XUchyS7Dtf0APT251N2ToZmHyQW1Op67GA0XG7e3pA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":52283790,"first_name":"Luisa Consuelo","middle_initials":"","last_name":"Rubiano Perea","page_name":"LRubianoPerea","domain_name":"javerianacali","created_at":"2016-08-20T06:55:56.486-07:00","display_name":"Luisa Consuelo Rubiano Perea","url":"https://javerianacali.academia.edu/LRubianoPerea"},"attachments":[{"id":87653395,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/87653395/thumbnails/1.jpg","file_name":"14760584.1.3.27720220617-1-1c6losp.pdf","download_url":"https://www.academia.edu/attachments/87653395/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Immunogenicity_and_reactogenicity_of_DTP.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/87653395/14760584.1.3.27720220617-1-1c6losp-libre.pdf?1655475759=\u0026response-content-disposition=attachment%3B+filename%3DImmunogenicity_and_reactogenicity_of_DTP.pdf\u0026Expires=1732779776\u0026Signature=ISJQn59Lal1BZDPTKcOhYc~kVuUUI4GM61nQT4gdG1UzNZ3ARaMxyr6sXoFam8Cj2OA-VF9Rj01a9qFwJ~fPvEhjNfKe6mFTg6Ff0dSx-CS5f2jG62flfZOPIPnFblZcRbhA1C~qzOu6qvJta6zVeid9qn1VucP1inbmW5D-AmMICSe9W6lbEMkQdHmKP98NJ1qgtRjTjf4z2vYJdm8s-a2LfpepLaNN30IrvgXpW3a0noy-IZgFdcWygc5Mixs3q3ZS1Qwdteg5ONulzIxU8hG0zLTdEV0PTAu3p3O~84J2XUchyS7Dtf0APT251N2ToZmHyQW1Op67GA0XG7e3pA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3261,"name":"Colombia","url":"https://www.academia.edu/Documents/in/Colombia"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":112817,"name":"Expert","url":"https://www.academia.edu/Documents/in/Expert"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant"},{"id":1334751,"name":"Hepatitis B Vaccine","url":"https://www.academia.edu/Documents/in/Hepatitis_B_Vaccine"},{"id":1529194,"name":"Hepatitis B Vaccines","url":"https://www.academia.edu/Documents/in/Hepatitis_B_Vaccines"}],"urls":[{"id":21521096,"url":"http://www.tandfonline.com/doi/pdf/10.1586/14760584.1.3.277"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="77455625"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/77455625/Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony"><img alt="Research paper thumbnail of Possible Links between Sickle Cell Crisis and Pentavalent Antimony" class="work-thumbnail" src="https://attachments.academia-assets.com/84881971/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/77455625/Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony">Possible Links between Sickle Cell Crisis and Pentavalent Antimony</a></div><div class="wp-workCard_item"><span>American Journal of Tropical Medicine and Hygiene</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5f3ae5479b0a5f5d9a6a067102ad871e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":84881971,"asset_id":77455625,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/84881971/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="77455625"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="77455625"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 77455625; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31550082"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31550082/Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine"><img alt="Research paper thumbnail of Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31550082/Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine">Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PilarRubio5">Pilar Rubio</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://javerianacali.academia.edu/LRubianoPerea">Luisa Consuelo Rubiano Perea</a></span></div><div class="wp-workCard_item"><span>Expert Review of Vaccines</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To evaluate, in an open study, the immunogenicity, safety and reactogenicity of a birth dose of h...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To evaluate, in an open study, the immunogenicity, safety and reactogenicity of a birth dose of hepatitis B vaccine followed by a three-dose course of diphtheria-tetanus whole-cell pertussis-hepatitis B vaccine, extemporaneously mixed with Haemophilus influenzae b (Hib) vaccine. At 2, 4 and 6 months of age, a single group of 120 Colombian infants were enrolled in this study to receive a regimen consisting of three doses of the combination vaccine following a dose of hepatitis B vaccine at birth. Seroprotection/vaccine response rates to all vaccine antigens was 98-100% 1 month after completion of the full vaccination course. The vaccine had an acceptable reactogenicity profile and the incidence of reported local and general symptoms decreased with the administration of subsequent vaccine doses. The mixed DTPw-HB/Hib vaccine was safe and well-tolerated, with high immunogenicity against all component antigens. Compared with previous studies, reactogenicity did not increase with the additional dose of hepatitis B vaccine given at birth. The DTPw-HB/Hib combination can be used to provide primary vaccination of infants who have already received a first dose of hepatitis B vaccine at birth.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31550082"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31550082"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31550082; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31550082]").text(description); $(".js-view-count[data-work-id=31550082]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31550082; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31550082']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31550082, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31550082]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31550082,"title":"Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine","translated_title":"","metadata":{"abstract":"To evaluate, in an open study, the immunogenicity, safety and reactogenicity of a birth dose of hepatitis B vaccine followed by a three-dose course of diphtheria-tetanus whole-cell pertussis-hepatitis B vaccine, extemporaneously mixed with Haemophilus influenzae b (Hib) vaccine. At 2, 4 and 6 months of age, a single group of 120 Colombian infants were enrolled in this study to receive a regimen consisting of three doses of the combination vaccine following a dose of hepatitis B vaccine at birth. Seroprotection/vaccine response rates to all vaccine antigens was 98-100% 1 month after completion of the full vaccination course. The vaccine had an acceptable reactogenicity profile and the incidence of reported local and general symptoms decreased with the administration of subsequent vaccine doses. The mixed DTPw-HB/Hib vaccine was safe and well-tolerated, with high immunogenicity against all component antigens. Compared with previous studies, reactogenicity did not increase with the additional dose of hepatitis B vaccine given at birth. The DTPw-HB/Hib combination can be used to provide primary vaccination of infants who have already received a first dose of hepatitis B vaccine at birth.","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Expert Review of Vaccines"},"translated_abstract":"To evaluate, in an open study, the immunogenicity, safety and reactogenicity of a birth dose of hepatitis B vaccine followed by a three-dose course of diphtheria-tetanus whole-cell pertussis-hepatitis B vaccine, extemporaneously mixed with Haemophilus influenzae b (Hib) vaccine. At 2, 4 and 6 months of age, a single group of 120 Colombian infants were enrolled in this study to receive a regimen consisting of three doses of the combination vaccine following a dose of hepatitis B vaccine at birth. Seroprotection/vaccine response rates to all vaccine antigens was 98-100% 1 month after completion of the full vaccination course. The vaccine had an acceptable reactogenicity profile and the incidence of reported local and general symptoms decreased with the administration of subsequent vaccine doses. The mixed DTPw-HB/Hib vaccine was safe and well-tolerated, with high immunogenicity against all component antigens. Compared with previous studies, reactogenicity did not increase with the additional dose of hepatitis B vaccine given at birth. The DTPw-HB/Hib combination can be used to provide primary vaccination of infants who have already received a first dose of hepatitis B vaccine at birth.","internal_url":"https://www.academia.edu/31550082/Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine","translated_internal_url":"","created_at":"2017-02-21T14:45:07.377-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60446712,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":27731172,"work_id":31550082,"tagging_user_id":60446712,"tagged_user_id":null,"co_author_invite_id":1974469,"email":"p***o@emcali.net.co","display_order":0,"name":"Pío López","title":"Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine"},{"id":27731183,"work_id":31550082,"tagging_user_id":60446712,"tagged_user_id":52283790,"co_author_invite_id":5455927,"email":"l***o@gmail.com","affiliation":"Pontificia Universidad Javeriana, Cali","display_order":4194304,"name":"Luisa Consuelo Rubiano Perea","title":"Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine"},{"id":27731184,"work_id":31550082,"tagging_user_id":60446712,"tagged_user_id":null,"co_author_invite_id":2677833,"email":"m***5@gmail.com","display_order":6291456,"name":"Maria Del Pilar Rubio","title":"Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine"}],"downloadable_attachments":[],"slug":"Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":60446712,"first_name":"Pilar","middle_initials":null,"last_name":"Rubio","page_name":"PilarRubio5","domain_name":"independent","created_at":"2017-02-21T14:40:12.955-08:00","display_name":"Pilar Rubio","url":"https://independent.academia.edu/PilarRubio5"},"attachments":[],"research_interests":[{"id":3261,"name":"Colombia","url":"https://www.academia.edu/Documents/in/Colombia"},{"id":112817,"name":"Expert","url":"https://www.academia.edu/Documents/in/Expert"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant"},{"id":1334751,"name":"Hepatitis B Vaccine","url":"https://www.academia.edu/Documents/in/Hepatitis_B_Vaccine"},{"id":1529194,"name":"Hepatitis B Vaccines","url":"https://www.academia.edu/Documents/in/Hepatitis_B_Vaccines"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28662230"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28662230/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony"><img alt="Research paper thumbnail of Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony" class="work-thumbnail" src="https://attachments.academia-assets.com/49039226/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28662230/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony">Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sb v revealed that a common pathway (glutathione) may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb v , and SCC. Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sb v caused the SCC.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fbaef9cea54dda6c8bb4cd9a3ebfa92c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49039226,"asset_id":28662230,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49039226/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28662230"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28662230"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28662230; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28662230]").text(description); $(".js-view-count[data-work-id=28662230]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28662230; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28662230']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28662230, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fbaef9cea54dda6c8bb4cd9a3ebfa92c" } } $('.js-work-strip[data-work-id=28662230]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28662230,"title":"Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony","translated_title":"","metadata":{"abstract":"For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sb v revealed that a common pathway (glutathione) may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb v , and SCC. Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sb v caused the SCC."},"translated_abstract":"For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sb v revealed that a common pathway (glutathione) may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb v , and SCC. Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sb v caused the SCC.","internal_url":"https://www.academia.edu/28662230/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony","translated_internal_url":"","created_at":"2016-09-22T08:25:56.348-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52283790,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":24689232,"work_id":28662230,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":3140169,"email":"n***t@ucla.edu","display_order":0,"name":"Noah Craft","title":"Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony"},{"id":24689233,"work_id":28662230,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455937,"email":"n***r@email.unc.edu","display_order":4194304,"name":"Nancy Baker","title":"Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony"},{"id":24689236,"work_id":28662230,"tagging_user_id":52283790,"tagged_user_id":42857674,"co_author_invite_id":null,"email":"v***o@ugr.es","display_order":6291456,"name":"Victor Blanco","title":"Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony"},{"id":24689237,"work_id":28662230,"tagging_user_id":52283790,"tagged_user_id":34283737,"co_author_invite_id":null,"email":"j***z@uvigo.es","display_order":7340032,"name":"Javier Martínez","title":"Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony"}],"downloadable_attachments":[{"id":49039226,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49039226/thumbnails/1.jpg","file_name":"Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony.pdf","download_url":"https://www.academia.edu/attachments/49039226/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Case_Report_Possible_Links_between_Sickl.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49039226/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony-libre.pdf?1474558355=\u0026response-content-disposition=attachment%3B+filename%3DCase_Report_Possible_Links_between_Sickl.pdf\u0026Expires=1732779776\u0026Signature=OWGEp1EbAFW6-YCbvxVRXnttbhFrIvEvt3MLSTxhfYCsvQ7B3gq45VF3SM9DoxVv59pYXzHbDbR9lBg1hvmEMKzEeQvZ7ILL6dB1wxDeM1NbuyXuiBnppE9mTWPp6oPJpj7ATMmW-2-rC-pzDgfiD1lH0mia6YQbJgGR8~SDeuypKX7NGrd~W-rMMS~PClcK3wWPxMejhPTDKHz1aVHeJZv7BOCsa021Zz3tPSkdnQhF6TrJEbXMyx96cGxYTTrJSvyqrx1xA36~6~J6EQW-9larePBbk3Toj6hOXE2RKAJ8r0ISHHEIdhqxwfPa~NKQM4woVpo0Ua-m4oTulH1rng__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":52283790,"first_name":"Luisa Consuelo","middle_initials":"","last_name":"Rubiano Perea","page_name":"LRubianoPerea","domain_name":"javerianacali","created_at":"2016-08-20T06:55:56.486-07:00","display_name":"Luisa Consuelo Rubiano Perea","url":"https://javerianacali.academia.edu/LRubianoPerea"},"attachments":[{"id":49039226,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49039226/thumbnails/1.jpg","file_name":"Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony.pdf","download_url":"https://www.academia.edu/attachments/49039226/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Case_Report_Possible_Links_between_Sickl.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49039226/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony-libre.pdf?1474558355=\u0026response-content-disposition=attachment%3B+filename%3DCase_Report_Possible_Links_between_Sickl.pdf\u0026Expires=1732779776\u0026Signature=OWGEp1EbAFW6-YCbvxVRXnttbhFrIvEvt3MLSTxhfYCsvQ7B3gq45VF3SM9DoxVv59pYXzHbDbR9lBg1hvmEMKzEeQvZ7ILL6dB1wxDeM1NbuyXuiBnppE9mTWPp6oPJpj7ATMmW-2-rC-pzDgfiD1lH0mia6YQbJgGR8~SDeuypKX7NGrd~W-rMMS~PClcK3wWPxMejhPTDKHz1aVHeJZv7BOCsa021Zz3tPSkdnQhF6TrJEbXMyx96cGxYTTrJSvyqrx1xA36~6~J6EQW-9larePBbk3Toj6hOXE2RKAJ8r0ISHHEIdhqxwfPa~NKQM4woVpo0Ua-m4oTulH1rng__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28661839"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28661839/Treatment_Failure_and_Miltefosine_Susceptibility_in_Dermal_Leishmaniasis_Caused_by_Leishmania_Subgenus_Viannia_Species"><img alt="Research paper thumbnail of Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species" class="work-thumbnail" src="https://attachments.academia-assets.com/49038713/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28661839/Treatment_Failure_and_Miltefosine_Susceptibility_in_Dermal_Leishmaniasis_Caused_by_Leishmania_Subgenus_Viannia_Species">Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania (...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania (Viannia) species are poorly understood. Prospective evaluation of drug susceptibility of strains isolated from individual patients before drug exposure and at clinical failure allows intrinsic and acquired differences in susceptibility to be discerned and analyzed. To determine whether intrinsic susceptibility or loss of susceptibility to miltefosine contributed to treatment failure, we evaluated the miltefosine susceptibility of intracellular amastigotes and promastigotes of six Leishmania (Viannia) braziliensis and six Leishmania (Viannia) panamensis strains isolated sequentially, at diagnosis and treatment failure, from two children and four adults >55 years old with concurrent conditions. Four patients presented only cutaneous lesions, one had mucosal disease, and one had disseminated mucocutaneous disease. Expression of the Leishmania drug transporter genes abca2, abca3, abcc2, abcc3, abcg4, abcg6, and LbMT was evaluated by quantitative reverse transcription-PCR (qRT-PCR). Intracellular amastigotes (median 50% effective concentration [EC 50 ], 10.7 mol/liter) were more susceptible to miltefosine than promastigotes (median EC 50 , 55.3 mol/liter) (P < 0.0001). Loss of susceptibility at failure, demonstrated by a miltefosine EC 50 of >32 mol/liter (the upper limit of intracel-lular amastigote assay), occurred in L. panamensis infection in a child and in L. braziliensis infection in an adult and was accompanied by decreased expression of the miltefosine transporter LbMT (LbMT/-tubulin, 0.42-to 0.26-fold [P 0.039] and 0.70-to 0.57-fold [P 0.009], respectively). LbMT gene polymorphisms were not associated with susceptibility phenotype. Leishma-nia ABCA3 transporter expression was inversely correlated with miltefosine susceptibility (r 0.605; P 0.037). Loss of susceptibility is one of multiple factors involved in failure of miltefosine treatment in dermal leishmaniasis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7be60831ad74028894be27c84b40fbf0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49038713,"asset_id":28661839,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49038713/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28661839"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28661839"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28661839; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28661839]").text(description); $(".js-view-count[data-work-id=28661839]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28661839; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28661839']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28661839, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7be60831ad74028894be27c84b40fbf0" } } $('.js-work-strip[data-work-id=28661839]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28661839,"title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species","translated_title":"","metadata":{"abstract":"Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania (Viannia) species are poorly understood. Prospective evaluation of drug susceptibility of strains isolated from individual patients before drug exposure and at clinical failure allows intrinsic and acquired differences in susceptibility to be discerned and analyzed. To determine whether intrinsic susceptibility or loss of susceptibility to miltefosine contributed to treatment failure, we evaluated the miltefosine susceptibility of intracellular amastigotes and promastigotes of six Leishmania (Viannia) braziliensis and six Leishmania (Viannia) panamensis strains isolated sequentially, at diagnosis and treatment failure, from two children and four adults \u003e55 years old with concurrent conditions. Four patients presented only cutaneous lesions, one had mucosal disease, and one had disseminated mucocutaneous disease. Expression of the Leishmania drug transporter genes abca2, abca3, abcc2, abcc3, abcg4, abcg6, and LbMT was evaluated by quantitative reverse transcription-PCR (qRT-PCR). Intracellular amastigotes (median 50% effective concentration [EC 50 ], 10.7 mol/liter) were more susceptible to miltefosine than promastigotes (median EC 50 , 55.3 mol/liter) (P \u003c 0.0001). Loss of susceptibility at failure, demonstrated by a miltefosine EC 50 of \u003e32 mol/liter (the upper limit of intracel-lular amastigote assay), occurred in L. panamensis infection in a child and in L. braziliensis infection in an adult and was accompanied by decreased expression of the miltefosine transporter LbMT (LbMT/-tubulin, 0.42-to 0.26-fold [P 0.039] and 0.70-to 0.57-fold [P 0.009], respectively). LbMT gene polymorphisms were not associated with susceptibility phenotype. Leishma-nia ABCA3 transporter expression was inversely correlated with miltefosine susceptibility (r 0.605; P 0.037). Loss of susceptibility is one of multiple factors involved in failure of miltefosine treatment in dermal leishmaniasis."},"translated_abstract":"Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania (Viannia) species are poorly understood. Prospective evaluation of drug susceptibility of strains isolated from individual patients before drug exposure and at clinical failure allows intrinsic and acquired differences in susceptibility to be discerned and analyzed. To determine whether intrinsic susceptibility or loss of susceptibility to miltefosine contributed to treatment failure, we evaluated the miltefosine susceptibility of intracellular amastigotes and promastigotes of six Leishmania (Viannia) braziliensis and six Leishmania (Viannia) panamensis strains isolated sequentially, at diagnosis and treatment failure, from two children and four adults \u003e55 years old with concurrent conditions. Four patients presented only cutaneous lesions, one had mucosal disease, and one had disseminated mucocutaneous disease. Expression of the Leishmania drug transporter genes abca2, abca3, abcc2, abcc3, abcg4, abcg6, and LbMT was evaluated by quantitative reverse transcription-PCR (qRT-PCR). Intracellular amastigotes (median 50% effective concentration [EC 50 ], 10.7 mol/liter) were more susceptible to miltefosine than promastigotes (median EC 50 , 55.3 mol/liter) (P \u003c 0.0001). Loss of susceptibility at failure, demonstrated by a miltefosine EC 50 of \u003e32 mol/liter (the upper limit of intracel-lular amastigote assay), occurred in L. panamensis infection in a child and in L. braziliensis infection in an adult and was accompanied by decreased expression of the miltefosine transporter LbMT (LbMT/-tubulin, 0.42-to 0.26-fold [P 0.039] and 0.70-to 0.57-fold [P 0.009], respectively). LbMT gene polymorphisms were not associated with susceptibility phenotype. Leishma-nia ABCA3 transporter expression was inversely correlated with miltefosine susceptibility (r 0.605; P 0.037). 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Buenaventura, a soc...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Congenital syphilis (CS) is a major global public health<br />problem. Buenaventura, a socioeconomically deprived municipality in the<br />Colombian Pacific Coast, accounts for 6.6% of all CS cases in Colombia.<br />To begin to understand the main reasons for the high rates of the disease in<br />Buenaventura, we conducted a retrospective electronic health record analysis<br />of all infants admitted with CS during the first 7 months of 2011 to the<br />Hospital Departamental de Buenaventura, the city’s main birthing hospital.<br />Methods: The diagnosis of gestational syphilis and CS was based on a<br />predefined Colombian public health service algorithm. Clinical, laboratory,<br />and sociodemographic parameters for all infants studied, including<br />maternal access to prenatal care, syphilis serologic diagnosis, and<br />adequacy of penicillin treatment, were abstracted and analyzed.<br />Results: A total of 89 infants met the case definition for CS. Most<br />mothers (80%) were affiliated with government-regulated or private health<br />care insurance plans. While 64 (70%) of 92 attended at least 1 antenatal<br />care visit and 59 of these 64 (84%) were screened for syphilis, only<br />5 (8%) of 59 received appropriate antibiotic therapy. Although most infants<br />were asymptomatic at birth, prematurity (15/82) was common. Two<br />infants died in the neonatal period, and 5 pregnancies ended in stillbirth.<br />Conclusions: Our findings confirm that Buenaventura has a very high<br />incidence of CS and demonstrate that existing antenatal care gestational<br />syphilis programs are flawed. Prevention strategies should emphasize enhanced<br />early syphilis screening in pregnancy, preferably through the<br />implementation of point-of-care testing in the community and same-day<br />treatment with at least 1 dose of penicillin.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a2e9ccfe390c412fe7a7ccb633bd10b2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49038692,"asset_id":28661807,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49038692/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28661807"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28661807"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28661807; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28661807]").text(description); $(".js-view-count[data-work-id=28661807]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28661807; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28661807']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28661807, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a2e9ccfe390c412fe7a7ccb633bd10b2" } } $('.js-work-strip[data-work-id=28661807]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28661807,"title":"Gestational and Congenital Syphilis Epidemic in the Colombian Pacific Coast","translated_title":"","metadata":{"abstract":"Background: Congenital syphilis (CS) is a major global public health\nproblem. Buenaventura, a socioeconomically deprived municipality in the\nColombian Pacific Coast, accounts for 6.6% of all CS cases in Colombia.\nTo begin to understand the main reasons for the high rates of the disease in\nBuenaventura, we conducted a retrospective electronic health record analysis\nof all infants admitted with CS during the first 7 months of 2011 to the\nHospital Departamental de Buenaventura, the city’s main birthing hospital.\nMethods: The diagnosis of gestational syphilis and CS was based on a\npredefined Colombian public health service algorithm. Clinical, laboratory,\nand sociodemographic parameters for all infants studied, including\nmaternal access to prenatal care, syphilis serologic diagnosis, and\nadequacy of penicillin treatment, were abstracted and analyzed.\nResults: A total of 89 infants met the case definition for CS. Most\nmothers (80%) were affiliated with government-regulated or private health\ncare insurance plans. While 64 (70%) of 92 attended at least 1 antenatal\ncare visit and 59 of these 64 (84%) were screened for syphilis, only\n5 (8%) of 59 received appropriate antibiotic therapy. Although most infants\nwere asymptomatic at birth, prematurity (15/82) was common. Two\ninfants died in the neonatal period, and 5 pregnancies ended in stillbirth.\nConclusions: Our findings confirm that Buenaventura has a very high\nincidence of CS and demonstrate that existing antenatal care gestational\nsyphilis programs are flawed. Prevention strategies should emphasize enhanced\nearly syphilis screening in pregnancy, preferably through the\nimplementation of point-of-care testing in the community and same-day\ntreatment with at least 1 dose of penicillin."},"translated_abstract":"Background: Congenital syphilis (CS) is a major global public health\nproblem. Buenaventura, a socioeconomically deprived municipality in the\nColombian Pacific Coast, accounts for 6.6% of all CS cases in Colombia.\nTo begin to understand the main reasons for the high rates of the disease in\nBuenaventura, we conducted a retrospective electronic health record analysis\nof all infants admitted with CS during the first 7 months of 2011 to the\nHospital Departamental de Buenaventura, the city’s main birthing hospital.\nMethods: The diagnosis of gestational syphilis and CS was based on a\npredefined Colombian public health service algorithm. Clinical, laboratory,\nand sociodemographic parameters for all infants studied, including\nmaternal access to prenatal care, syphilis serologic diagnosis, and\nadequacy of penicillin treatment, were abstracted and analyzed.\nResults: A total of 89 infants met the case definition for CS. Most\nmothers (80%) were affiliated with government-regulated or private health\ncare insurance plans. While 64 (70%) of 92 attended at least 1 antenatal\ncare visit and 59 of these 64 (84%) were screened for syphilis, only\n5 (8%) of 59 received appropriate antibiotic therapy. Although most infants\nwere asymptomatic at birth, prematurity (15/82) was common. Two\ninfants died in the neonatal period, and 5 pregnancies ended in stillbirth.\nConclusions: Our findings confirm that Buenaventura has a very high\nincidence of CS and demonstrate that existing antenatal care gestational\nsyphilis programs are flawed. Prevention strategies should emphasize enhanced\nearly syphilis screening in pregnancy, preferably through the\nimplementation of point-of-care testing in the community and same-day\ntreatment with at least 1 dose of penicillin.","internal_url":"https://www.academia.edu/28661807/Gestational_and_Congenital_Syphilis_Epidemic_in_the_Colombian_Pacific_Coast","translated_internal_url":"","created_at":"2016-09-22T08:03:39.769-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52283790,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":24536803,"work_id":28661807,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455930,"email":"m***n@cideim.org.co","display_order":1,"name":"Maria Castrillón","title":"Gestational and Congenital Syphilis Epidemic in the Colombian Pacific Coast"},{"id":24536805,"work_id":28661807,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455931,"email":"m***o@valledelcauca.gov.co","display_order":3,"name":"Martha Castaño","title":"Gestational and Congenital Syphilis Epidemic in the Colombian Pacific Coast"},{"id":24536806,"work_id":28661807,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455932,"email":"s***n@att.net","display_order":4,"name":"Juan Salazar","title":"Gestational and Congenital Syphilis Epidemic in the Colombian Pacific Coast"},{"id":24537204,"work_id":28661807,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455980,"email":"a***z@cideim.org.co","display_order":4194306,"name":"Adriana Cruz","title":"Gestational and Congenital Syphilis Epidemic in the Colombian Pacific Coast"}],"downloadable_attachments":[{"id":49038692,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49038692/thumbnails/1.jpg","file_name":"Gestational_and_Congenital_Syphilis_Epidemic_in_the.pdf","download_url":"https://www.academia.edu/attachments/49038692/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Gestational_and_Congenital_Syphilis_Epid.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49038692/Gestational_and_Congenital_Syphilis_Epidemic_in_the-libre.pdf?1474556734=\u0026response-content-disposition=attachment%3B+filename%3DGestational_and_Congenital_Syphilis_Epid.pdf\u0026Expires=1732779776\u0026Signature=Cnb9kqSKKDmJLGA5Kf4S87FJRv8ZaMj1rc1mYz-oDPH-GDQGZv0fIj8BqJWmbaptd7JNopweZqLRV61DUBE~e25HSAzH5~52O6GguK5IT5ppuogO~oMfTqZwscod013iCDB4bgW40R1Fs5~B2uHHB7Edv9BUGf9eof6t32rcucQSPhv8Fer-TrQHFDX5n1ZQxUZg1mCycLroBK5lDqcvataOWFuvqh4IesskVs7KS6Nm9nXfTfaW46EvZv0OXtLR9t1nzV5UgywhOOCzzPXYA~ywlmc0xPOEs74XKo9fDFLaYgHRP19FEj66jGhczJ4bxgB0K3twyyrpjwEXrXeJ6A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Gestational_and_Congenital_Syphilis_Epidemic_in_the_Colombian_Pacific_Coast","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":52283790,"first_name":"Luisa Consuelo","middle_initials":"","last_name":"Rubiano Perea","page_name":"LRubianoPerea","domain_name":"javerianacali","created_at":"2016-08-20T06:55:56.486-07:00","display_name":"Luisa Consuelo Rubiano Perea","url":"https://javerianacali.academia.edu/LRubianoPerea"},"attachments":[{"id":49038692,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49038692/thumbnails/1.jpg","file_name":"Gestational_and_Congenital_Syphilis_Epidemic_in_the.pdf","download_url":"https://www.academia.edu/attachments/49038692/download_file?st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Gestational_and_Congenital_Syphilis_Epid.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49038692/Gestational_and_Congenital_Syphilis_Epidemic_in_the-libre.pdf?1474556734=\u0026response-content-disposition=attachment%3B+filename%3DGestational_and_Congenital_Syphilis_Epid.pdf\u0026Expires=1732779776\u0026Signature=Cnb9kqSKKDmJLGA5Kf4S87FJRv8ZaMj1rc1mYz-oDPH-GDQGZv0fIj8BqJWmbaptd7JNopweZqLRV61DUBE~e25HSAzH5~52O6GguK5IT5ppuogO~oMfTqZwscod013iCDB4bgW40R1Fs5~B2uHHB7Edv9BUGf9eof6t32rcucQSPhv8Fer-TrQHFDX5n1ZQxUZg1mCycLroBK5lDqcvataOWFuvqh4IesskVs7KS6Nm9nXfTfaW46EvZv0OXtLR9t1nzV5UgywhOOCzzPXYA~ywlmc0xPOEs74XKo9fDFLaYgHRP19FEj66jGhczJ4bxgB0K3twyyrpjwEXrXeJ6A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1088,"name":"Infectious disease epidemiology","url":"https://www.academia.edu/Documents/in/Infectious_disease_epidemiology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28661789"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28661789/Noninferiority_of_Miltefosine_Versus_Meglumine_Antimoniate_for_Cutaneous_Leishmaniasis_in_Children"><img alt="Research paper thumbnail of Noninferiority of Miltefosine Versus Meglumine Antimoniate for Cutaneous Leishmaniasis in Children" class="work-thumbnail" src="https://attachments.academia-assets.com/49038672/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28661789/Noninferiority_of_Miltefosine_Versus_Meglumine_Antimoniate_for_Cutaneous_Leishmaniasis_in_Children">Noninferiority of Miltefosine Versus Meglumine Antimoniate for Cutaneous Leishmaniasis in Children</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://javerianacali.academia.edu/LRubianoPerea">Luisa Consuelo Rubiano Perea</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/IsabelBarraquer">Isabel Barraquer</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LydaOsorio">Lyda Osorio</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background. Children have a lower response rate to antimonial drugs and higher elimination rate o...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. Children have a lower response rate to antimonial drugs and higher elimination rate of antimony<br />(Sb) than adults. Oral miltefosine has not been evaluated for pediatric cutaneous leishmaniasis.<br />Methods. A randomized, noninferiority clinical trial with masked evaluation was conducted at 3 locations in<br />Colombia where Leishmania panamensis and Leishmania guyanensis predominated. One hundred sixteen children<br />aged 2–12 years with parasitologically confirmed cutaneous leishmaniasis were randomized to directly observed<br />treatment with meglumine antimoniate (20 mg Sb/kg/d for 20 days; intramuscular) (n 5 58) or miltefosine (1.8–<br />2.5 mg/kg/d for 28 days; by mouth) (n 5 58). Primary outcome was treatment failure at or before week 26 after<br />initiation of treatment. Miltefosine was noninferior if the proportion of treatment failures was #15% higher than<br />achieved with meglumine antimoniate (1-sided test, a 5 .05).<br />Results. Ninety-five percent of children (111/116) completed follow-up evaluation. By intention-to-treat analysis,<br />failure rate was 17.2% (98% confidence interval [CI], 5.7%–28.7%) for miltefosine and 31% (98% CI, 16.9%–45.2%)<br />for meglumine antimoniate. The difference between treatment groups was 13.8%, (98% CI, 24.5% to 32%)<br />(P 5 .04). Adverse events were mild for both treatments.<br />Conclusions. Miltefosine is noninferior to meglumine antimoniate for treatment of pediatric cutaneous<br />leishmaniasis caused by Leishmania (Viannia) species. Advantages of oral administration and low toxicity favor<br />use of miltefosine in children.<br />Clinical Trial Registration. NCT00487253.<br />Internal</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eb95ff1f29e5a611ae7bd170c6cf2189" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49038672,"asset_id":28661789,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49038672/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28661789"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28661789"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28661789; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28661789]").text(description); $(".js-view-count[data-work-id=28661789]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28661789; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28661789']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28661789, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "eb95ff1f29e5a611ae7bd170c6cf2189" } } $('.js-work-strip[data-work-id=28661789]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28661789,"title":"Noninferiority of Miltefosine Versus Meglumine Antimoniate for Cutaneous Leishmaniasis in Children","translated_title":"","metadata":{"abstract":"Background. Children have a lower response rate to antimonial drugs and higher elimination rate of antimony\n(Sb) than adults. Oral miltefosine has not been evaluated for pediatric cutaneous leishmaniasis.\nMethods. A randomized, noninferiority clinical trial with masked evaluation was conducted at 3 locations in\nColombia where Leishmania panamensis and Leishmania guyanensis predominated. One hundred sixteen children\naged 2–12 years with parasitologically confirmed cutaneous leishmaniasis were randomized to directly observed\ntreatment with meglumine antimoniate (20 mg Sb/kg/d for 20 days; intramuscular) (n 5 58) or miltefosine (1.8–\n2.5 mg/kg/d for 28 days; by mouth) (n 5 58). Primary outcome was treatment failure at or before week 26 after\ninitiation of treatment. Miltefosine was noninferior if the proportion of treatment failures was #15% higher than\nachieved with meglumine antimoniate (1-sided test, a 5 .05).\nResults. Ninety-five percent of children (111/116) completed follow-up evaluation. By intention-to-treat analysis,\nfailure rate was 17.2% (98% confidence interval [CI], 5.7%–28.7%) for miltefosine and 31% (98% CI, 16.9%–45.2%)\nfor meglumine antimoniate. The difference between treatment groups was 13.8%, (98% CI, 24.5% to 32%)\n(P 5 .04). Adverse events were mild for both treatments.\nConclusions. Miltefosine is noninferior to meglumine antimoniate for treatment of pediatric cutaneous\nleishmaniasis caused by Leishmania (Viannia) species. Advantages of oral administration and low toxicity favor\nuse of miltefosine in children.\nClinical Trial Registration. NCT00487253.\nInternal"},"translated_abstract":"Background. Children have a lower response rate to antimonial drugs and higher elimination rate of antimony\n(Sb) than adults. Oral miltefosine has not been evaluated for pediatric cutaneous leishmaniasis.\nMethods. A randomized, noninferiority clinical trial with masked evaluation was conducted at 3 locations in\nColombia where Leishmania panamensis and Leishmania guyanensis predominated. One hundred sixteen children\naged 2–12 years with parasitologically confirmed cutaneous leishmaniasis were randomized to directly observed\ntreatment with meglumine antimoniate (20 mg Sb/kg/d for 20 days; intramuscular) (n 5 58) or miltefosine (1.8–\n2.5 mg/kg/d for 28 days; by mouth) (n 5 58). Primary outcome was treatment failure at or before week 26 after\ninitiation of treatment. Miltefosine was noninferior if the proportion of treatment failures was #15% higher than\nachieved with meglumine antimoniate (1-sided test, a 5 .05).\nResults. Ninety-five percent of children (111/116) completed follow-up evaluation. By intention-to-treat analysis,\nfailure rate was 17.2% (98% confidence interval [CI], 5.7%–28.7%) for miltefosine and 31% (98% CI, 16.9%–45.2%)\nfor meglumine antimoniate. The difference between treatment groups was 13.8%, (98% CI, 24.5% to 32%)\n(P 5 .04). Adverse events were mild for both treatments.\nConclusions. Miltefosine is noninferior to meglumine antimoniate for treatment of pediatric cutaneous\nleishmaniasis caused by Leishmania (Viannia) species. Advantages of oral administration and low toxicity favor\nuse of miltefosine in children.\nClinical Trial Registration. NCT00487253.\nInternal","internal_url":"https://www.academia.edu/28661789/Noninferiority_of_Miltefosine_Versus_Meglumine_Antimoniate_for_Cutaneous_Leishmaniasis_in_Children","translated_internal_url":"","created_at":"2016-09-22T08:01:19.310-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52283790,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":24536770,"work_id":28661789,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455921,"email":"l***o@emcali.net.co","display_order":1,"name":"Luisa Rubiano","title":"Noninferiority of Miltefosine Versus Meglumine Antimoniate for Cutaneous Leishmaniasis in Children"},{"id":24536771,"work_id":28661789,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5109472,"email":"c***o@cideim.org.co","display_order":2,"name":"María Miranda","title":"Noninferiority of Miltefosine Versus Meglumine Antimoniate for Cutaneous Leishmaniasis in 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94191004"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94191004/CO_oxidation_at_20_C_over_Au_SBA_15_catalysts_decorated_by_Fe2O3_nanoparticles"><img alt="Research paper thumbnail of CO oxidation at 20 °C over Au/SBA-15 catalysts decorated by Fe2O3 nanoparticles" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94191004/CO_oxidation_at_20_C_over_Au_SBA_15_catalysts_decorated_by_Fe2O3_nanoparticles">CO oxidation at 20 °C over Au/SBA-15 catalysts decorated by Fe2O3 nanoparticles</a></div><div class="wp-workCard_item"><span>Catalysis Communications</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This contribution describes the effect of SBA-15 substrate modification with variable amounts of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This contribution describes the effect of SBA-15 substrate modification with variable amounts of Fe2O3 (5, 10, 15 and 20wt.%) on the catalytic response of supported gold catalysts in CO oxidation at 20°C. 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Colombia busca estandarizar la atención en centros especializados, bajo las recomendaciones de la Guía de Práctica Clínica vigente y con una intervención multidisciplinaria. Objetivo: Determinar el cumplimiento de los indicadores de gestión en un programa para el manejo de pacientes que viven con VIH/SIDA, en una IPS especializada de Cali, Colombia. Métodos: Se hizo un estudio observacional, descriptivo y retrospectivo en pacientes mayores de 18 años que ingresaron al programa e iniciaron tratamiento antirretroviral, entre enero y diciembre de 2016. Se analizó información de 173 registros clínicos y datos reportados en la Cuenta de Alto Costo de pacientes con diagnóstico de VIH/SIDA. Se evaluaron 13 indicadores del área clínica, todos de proceso; tres de evaluación inicial, dos de monitoreo, seis de terapia y dos de prevención especifica.Resultad...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c6f5f75941539423b1735ef4b267e544" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89660796,"asset_id":84743589,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89660796/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="84743589"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="84743589"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 84743589; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=84743589]").text(description); $(".js-view-count[data-work-id=84743589]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 84743589; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='84743589']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 84743589, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c6f5f75941539423b1735ef4b267e544" } } $('.js-work-strip[data-work-id=84743589]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":84743589,"title":"Cumplimiento de los indicadores de proceso en un programa para el manejo de pacientes que viven con VIH/SIDA","translated_title":"","metadata":{"abstract":"Introducción: La infección por VIH/SIDA es un problema de salud pública para el cual se han desarrollado múltiples estrategias de control. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="84743588"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/84743588/Participatory_Visual_Methods_with_caregivers_of_children_with_Congenital_Zika_Syndrome_in_Colombia_A_case_study"><img alt="Research paper thumbnail of Participatory Visual Methods with caregivers of children with Congenital Zika Syndrome in Colombia: A case study" class="work-thumbnail" src="https://attachments.academia-assets.com/89660794/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/84743588/Participatory_Visual_Methods_with_caregivers_of_children_with_Congenital_Zika_Syndrome_in_Colombia_A_case_study">Participatory Visual Methods with caregivers of children with Congenital Zika Syndrome in Colombia: A case study</a></div><div class="wp-workCard_item"><span>Wellcome Open Research</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: This study explores the acceptability and feasibility of the use of two different Par...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: This study explores the acceptability and feasibility of the use of two different Participatory Visual Methods (Participatory Video and Digital Storytelling) in gathering information on the experiences and perspectives of carers of children with Congenital Zika Syndrome within Colombia. Methods: Participatory Video was used to assess the impact of the Juntos parent-support intervention in the lives of carers, and Digital Storytelling was used to explore the healthcare access for these children. In-depth interviews were conducted to probe participants on their views of these methods. Results: One Participatory Video was produced and four Digital Stories. Of the initial eight caregivers who took part in the Participatory Video process, four completed both the Digital Storytelling process and an in-depth interview about their experiences. The main factors shaping participants’ experiences related to the skills learned in making the videos, the feeling of collectiveness and...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ce35c48a49331d083f01dfb04d0c02cc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89660794,"asset_id":84743588,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89660794/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="84743588"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="84743588"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 84743588; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=84743588]").text(description); $(".js-view-count[data-work-id=84743588]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 84743588; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='84743588']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 84743588, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ce35c48a49331d083f01dfb04d0c02cc" } } $('.js-work-strip[data-work-id=84743588]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":84743588,"title":"Participatory Visual Methods with caregivers of children with Congenital Zika Syndrome in Colombia: A case study","translated_title":"","metadata":{"abstract":"Background: This study explores the acceptability and feasibility of the use of two different Participatory Visual Methods (Participatory Video and Digital Storytelling) in gathering information on the experiences and perspectives of carers of children with Congenital Zika Syndrome within Colombia. Methods: Participatory Video was used to assess the impact of the Juntos parent-support intervention in the lives of carers, and Digital Storytelling was used to explore the healthcare access for these children. In-depth interviews were conducted to probe participants on their views of these methods. Results: One Participatory Video was produced and four Digital Stories. Of the initial eight caregivers who took part in the Participatory Video process, four completed both the Digital Storytelling process and an in-depth interview about their experiences. The main factors shaping participants’ experiences related to the skills learned in making the videos, the feeling of collectiveness and...","publisher":"F1000 Research Ltd","publication_name":"Wellcome Open Research"},"translated_abstract":"Background: This study explores the acceptability and feasibility of the use of two different Participatory Visual Methods (Participatory Video and Digital Storytelling) in gathering information on the experiences and perspectives of carers of children with Congenital Zika Syndrome within Colombia. Methods: Participatory Video was used to assess the impact of the Juntos parent-support intervention in the lives of carers, and Digital Storytelling was used to explore the healthcare access for these children. In-depth interviews were conducted to probe participants on their views of these methods. Results: One Participatory Video was produced and four Digital Stories. Of the initial eight caregivers who took part in the Participatory Video process, four completed both the Digital Storytelling process and an in-depth interview about their experiences. The main factors shaping participants’ experiences related to the skills learned in making the videos, the feeling of collectiveness and...","internal_url":"https://www.academia.edu/84743588/Participatory_Visual_Methods_with_caregivers_of_children_with_Congenital_Zika_Syndrome_in_Colombia_A_case_study","translated_internal_url":"","created_at":"2022-08-14T18:58:48.410-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52283790,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":89660794,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89660794/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/89660794/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Participatory_Visual_Methods_with_caregi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89660794/pdf-libre.pdf?1660529274=\u0026response-content-disposition=attachment%3B+filename%3DParticipatory_Visual_Methods_with_caregi.pdf\u0026Expires=1732779776\u0026Signature=NRYjguCcVIwo8qha5k-o1dYBxD44b1gcK3IqbyOAKWRb0klU1fnWeXTDV-ImX7eMi5gF87eUeZ1Cm20fmj59jeD~yfjvkt0BBcYDAr4dU1lnRWe3BIDvnVDEa~7X-VsZ7pqAAWNQJcu2nsmB7N5L~IJ9oqUMd5UBtki54iOW9tpNKnWMcCs~KqXEYDCYdhrNYEwhe9xqbeggX7SOD3lMsjJ~DUZHSf8UrPop90H2uKKPVMXKgIwl0cXJDTxS-zTx8xeaN~Q-ktKMa4K~l6nVrb4ZFWR-t1cEyZ5KnwK0NdwjZLaN65wMJvjb3ceJcviZPB63YLgJiEq9i588T~ECfw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Participatory_Visual_Methods_with_caregivers_of_children_with_Congenital_Zika_Syndrome_in_Colombia_A_case_study","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":52283790,"first_name":"Luisa Consuelo","middle_initials":"","last_name":"Rubiano Perea","page_name":"LRubianoPerea","domain_name":"javerianacali","created_at":"2016-08-20T06:55:56.486-07:00","display_name":"Luisa Consuelo Rubiano Perea","url":"https://javerianacali.academia.edu/LRubianoPerea"},"attachments":[{"id":89660794,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89660794/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/89660794/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Participatory_Visual_Methods_with_caregi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89660794/pdf-libre.pdf?1660529274=\u0026response-content-disposition=attachment%3B+filename%3DParticipatory_Visual_Methods_with_caregi.pdf\u0026Expires=1732779776\u0026Signature=NRYjguCcVIwo8qha5k-o1dYBxD44b1gcK3IqbyOAKWRb0klU1fnWeXTDV-ImX7eMi5gF87eUeZ1Cm20fmj59jeD~yfjvkt0BBcYDAr4dU1lnRWe3BIDvnVDEa~7X-VsZ7pqAAWNQJcu2nsmB7N5L~IJ9oqUMd5UBtki54iOW9tpNKnWMcCs~KqXEYDCYdhrNYEwhe9xqbeggX7SOD3lMsjJ~DUZHSf8UrPop90H2uKKPVMXKgIwl0cXJDTxS-zTx8xeaN~Q-ktKMa4K~l6nVrb4ZFWR-t1cEyZ5KnwK0NdwjZLaN65wMJvjb3ceJcviZPB63YLgJiEq9i588T~ECfw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":22925563,"url":"https://wellcomeopenresearch.org/articles/7-107/v1/xml"}]}, dispatcherData: dispatcherData }); 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Drawing on experience developing an app for detecting and referring cases of cutaneous leishmaniasis in Colombia, called Guaral/app, we review key steps in creating such mobile health (mHealth) tools. These require consideration of the sociotechnical context using methods such as systems analysis and human-centered design (HCD), predicated on engagement and iteration with all stakeholders. We emphasize usability and technical concerns and describe the interdependency of technical and human considerations for mHealth systems in rural communities.","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"PLOS Neglected Tropical Diseases","grobid_abstract_attachment_id":89660795},"translated_abstract":null,"internal_url":"https://www.academia.edu/84743587/Developing_mobile_health_applications_for_neglected_tropical_disease_research","translated_internal_url":"","created_at":"2022-08-14T18:58:47.764-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52283790,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":89660795,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89660795/thumbnails/1.jpg","file_name":"e403e5fbb96c7495e43c889efa28b870363a.pdf","download_url":"https://www.academia.edu/attachments/89660795/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Developing_mobile_health_applications_fo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89660795/e403e5fbb96c7495e43c889efa28b870363a-libre.pdf?1660529271=\u0026response-content-disposition=attachment%3B+filename%3DDeveloping_mobile_health_applications_fo.pdf\u0026Expires=1732779776\u0026Signature=A-ujAb3naUvtKDxTV7Cl2Z0vCOkkEkBR2Npp9VjWZ8fUqH3Vy8ZFyQtB4XlCDTTnU111pJKcwyR5rqrqWBUfZZ8LzEDxK00vVTT4KVQrwIveKeonbwHzRPaFumXt05qTADJxEokB7ys0GJXLaMQZHFVCwpWdxfq0HumkxKn5~pGrE0QoKf9Twa4O8TkK7XJ3BlSQJmlA6lseu8VXB-eINgo9LKjGbIWc8JJ2mdGCaegn4J5jb0GAlFEK6kYFOzE5mKYkGAu9TQEaByfeKWf-p1OKHMx2fw6d1k~V-sO0m1Gvz7koaegEVq9hhjagS07BMAST0WrBicqm~FVuDc-i0w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Developing_mobile_health_applications_for_neglected_tropical_disease_research","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":52283790,"first_name":"Luisa Consuelo","middle_initials":"","last_name":"Rubiano Perea","page_name":"LRubianoPerea","domain_name":"javerianacali","created_at":"2016-08-20T06:55:56.486-07:00","display_name":"Luisa Consuelo Rubiano Perea","url":"https://javerianacali.academia.edu/LRubianoPerea"},"attachments":[{"id":89660795,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/89660795/thumbnails/1.jpg","file_name":"e403e5fbb96c7495e43c889efa28b870363a.pdf","download_url":"https://www.academia.edu/attachments/89660795/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Developing_mobile_health_applications_fo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/89660795/e403e5fbb96c7495e43c889efa28b870363a-libre.pdf?1660529271=\u0026response-content-disposition=attachment%3B+filename%3DDeveloping_mobile_health_applications_fo.pdf\u0026Expires=1732779776\u0026Signature=A-ujAb3naUvtKDxTV7Cl2Z0vCOkkEkBR2Npp9VjWZ8fUqH3Vy8ZFyQtB4XlCDTTnU111pJKcwyR5rqrqWBUfZZ8LzEDxK00vVTT4KVQrwIveKeonbwHzRPaFumXt05qTADJxEokB7ys0GJXLaMQZHFVCwpWdxfq0HumkxKn5~pGrE0QoKf9Twa4O8TkK7XJ3BlSQJmlA6lseu8VXB-eINgo9LKjGbIWc8JJ2mdGCaegn4J5jb0GAlFEK6kYFOzE5mKYkGAu9TQEaByfeKWf-p1OKHMx2fw6d1k~V-sO0m1Gvz7koaegEVq9hhjagS07BMAST0WrBicqm~FVuDc-i0w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26,"name":"Business","url":"https://www.academia.edu/Documents/in/Business"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":128002,"name":"Neglected tropical diseases","url":"https://www.academia.edu/Documents/in/Neglected_tropical_diseases"},{"id":270422,"name":"Tropical Disease","url":"https://www.academia.edu/Documents/in/Tropical_Disease"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":22925562,"url":"http://dx.plos.org/10.1371/journal.pntd.0006791"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="84743586"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/84743586/Parasitological_Confirmation_and_Analysis_of_Leishmania_Diversity_in_Asymptomatic_and_Subclinical_Infection_following_Resolution_of_Cutaneous_Leishmaniasis"><img alt="Research paper thumbnail of Parasitological Confirmation and Analysis of Leishmania Diversity in Asymptomatic and Subclinical Infection following Resolution of Cutaneous Leishmaniasis" class="work-thumbnail" src="https://attachments.academia-assets.com/89660808/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/84743586/Parasitological_Confirmation_and_Analysis_of_Leishmania_Diversity_in_Asymptomatic_and_Subclinical_Infection_following_Resolution_of_Cutaneous_Leishmaniasis">Parasitological Confirmation and Analysis of Leishmania Diversity in Asymptomatic and Subclinical Infection following Resolution of Cutaneous Leishmaniasis</a></div><div class="wp-workCard_item"><span>PLoS neglected tropical diseases</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The contribution of individuals with subclinical infection to the transmission and endemicity of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The contribution of individuals with subclinical infection to the transmission and endemicity of cutaneous leishmaniasis (CL) is unknown. Immunological evidence of exposure to Leishmania in residents of endemic areas has been the basis for defining the human population with asymptomatic infection. However, parasitological confirmation of subclinical infection is lacking. We investigated the presence and viability of Leishmania in blood and non-invasive mucosal tissue samples from individuals with immunological evidence of subclinical infection in endemic areas for CL caused by Leishmania (Viannia) in Colombia. Detection of Leishmania kDNA was conducted by PCR-Southern Blot, and parasite viability was confirmed by amplification of parasite 7SLRNA gene transcripts. A molecular tool for genetic diversity analysis of parasite populations causing persistent subclinical infection based on PCR amplification and sequence analysis of an 82bp region between kDNA conserved blocks 1 and 2 was d...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="912c9590dd3393ac442105a19386e4f5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89660808,"asset_id":84743586,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89660808/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="84743586"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="84743586"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 84743586; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=84743586]").text(description); $(".js-view-count[data-work-id=84743586]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 84743586; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='84743586']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 84743586, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "912c9590dd3393ac442105a19386e4f5" } } $('.js-work-strip[data-work-id=84743586]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":84743586,"title":"Parasitological Confirmation and Analysis of Leishmania Diversity in Asymptomatic and Subclinical Infection following Resolution of Cutaneous Leishmaniasis","translated_title":"","metadata":{"abstract":"The contribution of individuals with subclinical infection to the transmission and endemicity of cutaneous leishmaniasis (CL) is unknown. Immunological evidence of exposure to Leishmania in residents of endemic areas has been the basis for defining the human population with asymptomatic infection. However, parasitological confirmation of subclinical infection is lacking. We investigated the presence and viability of Leishmania in blood and non-invasive mucosal tissue samples from individuals with immunological evidence of subclinical infection in endemic areas for CL caused by Leishmania (Viannia) in Colombia. Detection of Leishmania kDNA was conducted by PCR-Southern Blot, and parasite viability was confirmed by amplification of parasite 7SLRNA gene transcripts. A molecular tool for genetic diversity analysis of parasite populations causing persistent subclinical infection based on PCR amplification and sequence analysis of an 82bp region between kDNA conserved blocks 1 and 2 was d...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"PLoS neglected tropical diseases"},"translated_abstract":"The contribution of individuals with subclinical infection to the transmission and endemicity of cutaneous leishmaniasis (CL) is unknown. Immunological evidence of exposure to Leishmania in residents of endemic areas has been the basis for defining the human population with asymptomatic infection. However, parasitological confirmation of subclinical infection is lacking. We investigated the presence and viability of Leishmania in blood and non-invasive mucosal tissue samples from individuals with immunological evidence of subclinical infection in endemic areas for CL caused by Leishmania (Viannia) in Colombia. Detection of Leishmania kDNA was conducted by PCR-Southern Blot, and parasite viability was confirmed by amplification of parasite 7SLRNA gene transcripts. 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data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/84743584/Treatment_Failure_and_Miltefosine_Susceptibility_in_Dermal_Leishmaniasis_Caused_by_Leishmania_Subgenus_Viannia_Species"><img alt="Research paper thumbnail of Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species" class="work-thumbnail" src="https://attachments.academia-assets.com/89660813/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/84743584/Treatment_Failure_and_Miltefosine_Susceptibility_in_Dermal_Leishmaniasis_Caused_by_Leishmania_Subgenus_Viannia_Species">Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species</a></div><div class="wp-workCard_item"><span>Antimicrobial Agents and Chemotherapy</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania (...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania ( Viannia ) species are poorly understood. Prospective evaluation of drug susceptibility of strains isolated from individual patients before drug exposure and at clinical failure allows intrinsic and acquired differences in susceptibility to be discerned and analyzed. To determine whether intrinsic susceptibility or loss of susceptibility to miltefosine contributed to treatment failure, we evaluated the miltefosine susceptibility of intracellular amastigotes and promastigotes of six Leishmania ( Viannia ) braziliensis and six Leishmania ( Viannia ) panamensis strains isolated sequentially, at diagnosis and treatment failure, from two children and four adults ≥55 years old with concurrent conditions. Four patients presented only cutaneous lesions, one had mucosal disease, and one had disseminated mucocutaneous disease. Expression of the Leishmania drug transporter genes abca2 , abca3 , abc...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="951b01ec23d10c1e04422c60f97655fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89660813,"asset_id":84743584,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89660813/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="84743584"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="84743584"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 84743584; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=84743584]").text(description); $(".js-view-count[data-work-id=84743584]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 84743584; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='84743584']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 84743584, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "951b01ec23d10c1e04422c60f97655fe" } } $('.js-work-strip[data-work-id=84743584]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":84743584,"title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species","translated_title":"","metadata":{"abstract":"Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania ( Viannia ) species are poorly understood. Prospective evaluation of drug susceptibility of strains isolated from individual patients before drug exposure and at clinical failure allows intrinsic and acquired differences in susceptibility to be discerned and analyzed. To determine whether intrinsic susceptibility or loss of susceptibility to miltefosine contributed to treatment failure, we evaluated the miltefosine susceptibility of intracellular amastigotes and promastigotes of six Leishmania ( Viannia ) braziliensis and six Leishmania ( Viannia ) panamensis strains isolated sequentially, at diagnosis and treatment failure, from two children and four adults ≥55 years old with concurrent conditions. Four patients presented only cutaneous lesions, one had mucosal disease, and one had disseminated mucocutaneous disease. Expression of the Leishmania drug transporter genes abca2 , abca3 , abc...","publisher":"American Society for Microbiology","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Antimicrobial Agents and Chemotherapy"},"translated_abstract":"Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania ( Viannia ) species are poorly understood. Prospective evaluation of drug susceptibility of strains isolated from individual patients before drug exposure and at clinical failure allows intrinsic and acquired differences in susceptibility to be discerned and analyzed. To determine whether intrinsic susceptibility or loss of susceptibility to miltefosine contributed to treatment failure, we evaluated the miltefosine susceptibility of intracellular amastigotes and promastigotes of six Leishmania ( Viannia ) braziliensis and six Leishmania ( Viannia ) panamensis strains isolated sequentially, at diagnosis and treatment failure, from two children and four adults ≥55 years old with concurrent conditions. Four patients presented only cutaneous lesions, one had mucosal disease, and one had disseminated mucocutaneous disease. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="84743552"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/84743552/Noninferiority_of_miltefosine_versus_meglumine_antimoniate_for_cutaneous_leishmaniasis_in_children"><img alt="Research paper thumbnail of Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children" class="work-thumbnail" src="https://attachments.academia-assets.com/89660775/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/84743552/Noninferiority_of_miltefosine_versus_meglumine_antimoniate_for_cutaneous_leishmaniasis_in_children">Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children</a></div><div class="wp-workCard_item"><span>The Journal of infectious diseases</span><span>, Jan 15, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Children have a lower response rate to antimonial drugs and higher elimination rate of antimony (...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Children have a lower response rate to antimonial drugs and higher elimination rate of antimony (Sb) than adults. Oral miltefosine has not been evaluated for pediatric cutaneous leishmaniasis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ae026e22bee04586d1da0244d282058d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":89660775,"asset_id":84743552,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/89660775/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="84743552"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="84743552"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 84743552; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=84743552]").text(description); $(".js-view-count[data-work-id=84743552]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 84743552; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='84743552']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 84743552, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ae026e22bee04586d1da0244d282058d" } } $('.js-work-strip[data-work-id=84743552]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":84743552,"title":"Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children","translated_title":"","metadata":{"abstract":"Children have a lower response rate to antimonial drugs and higher elimination rate of antimony (Sb) than adults. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="81699188"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/81699188/Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine"><img alt="Research paper thumbnail of Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine" class="work-thumbnail" src="https://attachments.academia-assets.com/87653395/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/81699188/Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine">Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine</a></div><div class="wp-workCard_item"><span>Expert Review of Vaccines</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="025f41d7a58af3366d4f54095b34d687" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":87653395,"asset_id":81699188,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/87653395/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="81699188"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="81699188"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 81699188; 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Methods: At 2, 4 and 6 months of age, a single group of 120 Colombian infants were enrolled in this study to receive a regimen consisting of three doses of the combination vaccine following a dose of hepatitis B vaccine at birth. Results: Seroprotection/vaccine response rates to all vaccine antigens was 98-100% 1 month after completion of the full vaccination course. The vaccine had an acceptable reactogenicity profile and the incidence of reported local and general symptoms decreased with the administration of subsequent vaccine doses. Conclusion: The mixed DTPw-HB/Hib vaccine was safe and well-tolerated, with high immunogenicity against all component antigens. Compared with previous studies, reactogenicity did not increase with the additional dose of hepatitis B vaccine given at birth. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31550082"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31550082/Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine"><img alt="Research paper thumbnail of Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31550082/Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine">Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/PilarRubio5">Pilar Rubio</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://javerianacali.academia.edu/LRubianoPerea">Luisa Consuelo Rubiano Perea</a></span></div><div class="wp-workCard_item"><span>Expert Review of Vaccines</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To evaluate, in an open study, the immunogenicity, safety and reactogenicity of a birth dose of h...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To evaluate, in an open study, the immunogenicity, safety and reactogenicity of a birth dose of hepatitis B vaccine followed by a three-dose course of diphtheria-tetanus whole-cell pertussis-hepatitis B vaccine, extemporaneously mixed with Haemophilus influenzae b (Hib) vaccine. At 2, 4 and 6 months of age, a single group of 120 Colombian infants were enrolled in this study to receive a regimen consisting of three doses of the combination vaccine following a dose of hepatitis B vaccine at birth. Seroprotection/vaccine response rates to all vaccine antigens was 98-100% 1 month after completion of the full vaccination course. The vaccine had an acceptable reactogenicity profile and the incidence of reported local and general symptoms decreased with the administration of subsequent vaccine doses. The mixed DTPw-HB/Hib vaccine was safe and well-tolerated, with high immunogenicity against all component antigens. Compared with previous studies, reactogenicity did not increase with the additional dose of hepatitis B vaccine given at birth. The DTPw-HB/Hib combination can be used to provide primary vaccination of infants who have already received a first dose of hepatitis B vaccine at birth.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31550082"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31550082"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31550082; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31550082]").text(description); $(".js-view-count[data-work-id=31550082]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31550082; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31550082']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31550082, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31550082]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31550082,"title":"Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine","translated_title":"","metadata":{"abstract":"To evaluate, in an open study, the immunogenicity, safety and reactogenicity of a birth dose of hepatitis B vaccine followed by a three-dose course of diphtheria-tetanus whole-cell pertussis-hepatitis B vaccine, extemporaneously mixed with Haemophilus influenzae b (Hib) vaccine. At 2, 4 and 6 months of age, a single group of 120 Colombian infants were enrolled in this study to receive a regimen consisting of three doses of the combination vaccine following a dose of hepatitis B vaccine at birth. Seroprotection/vaccine response rates to all vaccine antigens was 98-100% 1 month after completion of the full vaccination course. The vaccine had an acceptable reactogenicity profile and the incidence of reported local and general symptoms decreased with the administration of subsequent vaccine doses. The mixed DTPw-HB/Hib vaccine was safe and well-tolerated, with high immunogenicity against all component antigens. Compared with previous studies, reactogenicity did not increase with the additional dose of hepatitis B vaccine given at birth. The DTPw-HB/Hib combination can be used to provide primary vaccination of infants who have already received a first dose of hepatitis B vaccine at birth.","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Expert Review of Vaccines"},"translated_abstract":"To evaluate, in an open study, the immunogenicity, safety and reactogenicity of a birth dose of hepatitis B vaccine followed by a three-dose course of diphtheria-tetanus whole-cell pertussis-hepatitis B vaccine, extemporaneously mixed with Haemophilus influenzae b (Hib) vaccine. At 2, 4 and 6 months of age, a single group of 120 Colombian infants were enrolled in this study to receive a regimen consisting of three doses of the combination vaccine following a dose of hepatitis B vaccine at birth. Seroprotection/vaccine response rates to all vaccine antigens was 98-100% 1 month after completion of the full vaccination course. The vaccine had an acceptable reactogenicity profile and the incidence of reported local and general symptoms decreased with the administration of subsequent vaccine doses. The mixed DTPw-HB/Hib vaccine was safe and well-tolerated, with high immunogenicity against all component antigens. Compared with previous studies, reactogenicity did not increase with the additional dose of hepatitis B vaccine given at birth. The DTPw-HB/Hib combination can be used to provide primary vaccination of infants who have already received a first dose of hepatitis B vaccine at birth.","internal_url":"https://www.academia.edu/31550082/Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine","translated_internal_url":"","created_at":"2017-02-21T14:45:07.377-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60446712,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":27731172,"work_id":31550082,"tagging_user_id":60446712,"tagged_user_id":null,"co_author_invite_id":1974469,"email":"p***o@emcali.net.co","display_order":0,"name":"Pío López","title":"Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine"},{"id":27731183,"work_id":31550082,"tagging_user_id":60446712,"tagged_user_id":52283790,"co_author_invite_id":5455927,"email":"l***o@gmail.com","affiliation":"Pontificia Universidad Javeriana, Cali","display_order":4194304,"name":"Luisa Consuelo Rubiano Perea","title":"Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine"},{"id":27731184,"work_id":31550082,"tagging_user_id":60446712,"tagged_user_id":null,"co_author_invite_id":2677833,"email":"m***5@gmail.com","display_order":6291456,"name":"Maria Del Pilar Rubio","title":"Immunogenicity and reactogenicity of DTPw–HB/Hib vaccine administered to Colombian infants after a birth dose of hepatitis B vaccine"}],"downloadable_attachments":[],"slug":"Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":60446712,"first_name":"Pilar","middle_initials":null,"last_name":"Rubio","page_name":"PilarRubio5","domain_name":"independent","created_at":"2017-02-21T14:40:12.955-08:00","display_name":"Pilar Rubio","url":"https://independent.academia.edu/PilarRubio5"},"attachments":[],"research_interests":[{"id":3261,"name":"Colombia","url":"https://www.academia.edu/Documents/in/Colombia"},{"id":112817,"name":"Expert","url":"https://www.academia.edu/Documents/in/Expert"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant"},{"id":1334751,"name":"Hepatitis B Vaccine","url":"https://www.academia.edu/Documents/in/Hepatitis_B_Vaccine"},{"id":1529194,"name":"Hepatitis B Vaccines","url":"https://www.academia.edu/Documents/in/Hepatitis_B_Vaccines"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28662230"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28662230/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony"><img alt="Research paper thumbnail of Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony" class="work-thumbnail" src="https://attachments.academia-assets.com/49039226/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28662230/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony">Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sb v revealed that a common pathway (glutathione) may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb v , and SCC. Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sb v caused the SCC.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fbaef9cea54dda6c8bb4cd9a3ebfa92c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49039226,"asset_id":28662230,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49039226/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28662230"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28662230"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28662230; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28662230]").text(description); $(".js-view-count[data-work-id=28662230]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28662230; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28662230']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28662230, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fbaef9cea54dda6c8bb4cd9a3ebfa92c" } } $('.js-work-strip[data-work-id=28662230]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28662230,"title":"Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony","translated_title":"","metadata":{"abstract":"For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sb v revealed that a common pathway (glutathione) may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb v , and SCC. Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sb v caused the SCC."},"translated_abstract":"For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sb v revealed that a common pathway (glutathione) may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb v , and SCC. Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sb v caused the SCC.","internal_url":"https://www.academia.edu/28662230/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony","translated_internal_url":"","created_at":"2016-09-22T08:25:56.348-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52283790,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":24689232,"work_id":28662230,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":3140169,"email":"n***t@ucla.edu","display_order":0,"name":"Noah Craft","title":"Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony"},{"id":24689233,"work_id":28662230,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455937,"email":"n***r@email.unc.edu","display_order":4194304,"name":"Nancy Baker","title":"Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony"},{"id":24689236,"work_id":28662230,"tagging_user_id":52283790,"tagged_user_id":42857674,"co_author_invite_id":null,"email":"v***o@ugr.es","display_order":6291456,"name":"Victor Blanco","title":"Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony"},{"id":24689237,"work_id":28662230,"tagging_user_id":52283790,"tagged_user_id":34283737,"co_author_invite_id":null,"email":"j***z@uvigo.es","display_order":7340032,"name":"Javier Martínez","title":"Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony"}],"downloadable_attachments":[{"id":49039226,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49039226/thumbnails/1.jpg","file_name":"Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony.pdf","download_url":"https://www.academia.edu/attachments/49039226/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Case_Report_Possible_Links_between_Sickl.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49039226/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony-libre.pdf?1474558355=\u0026response-content-disposition=attachment%3B+filename%3DCase_Report_Possible_Links_between_Sickl.pdf\u0026Expires=1732779776\u0026Signature=OWGEp1EbAFW6-YCbvxVRXnttbhFrIvEvt3MLSTxhfYCsvQ7B3gq45VF3SM9DoxVv59pYXzHbDbR9lBg1hvmEMKzEeQvZ7ILL6dB1wxDeM1NbuyXuiBnppE9mTWPp6oPJpj7ATMmW-2-rC-pzDgfiD1lH0mia6YQbJgGR8~SDeuypKX7NGrd~W-rMMS~PClcK3wWPxMejhPTDKHz1aVHeJZv7BOCsa021Zz3tPSkdnQhF6TrJEbXMyx96cGxYTTrJSvyqrx1xA36~6~J6EQW-9larePBbk3Toj6hOXE2RKAJ8r0ISHHEIdhqxwfPa~NKQM4woVpo0Ua-m4oTulH1rng__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":52283790,"first_name":"Luisa Consuelo","middle_initials":"","last_name":"Rubiano Perea","page_name":"LRubianoPerea","domain_name":"javerianacali","created_at":"2016-08-20T06:55:56.486-07:00","display_name":"Luisa Consuelo Rubiano Perea","url":"https://javerianacali.academia.edu/LRubianoPerea"},"attachments":[{"id":49039226,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49039226/thumbnails/1.jpg","file_name":"Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony.pdf","download_url":"https://www.academia.edu/attachments/49039226/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Case_Report_Possible_Links_between_Sickl.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49039226/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony-libre.pdf?1474558355=\u0026response-content-disposition=attachment%3B+filename%3DCase_Report_Possible_Links_between_Sickl.pdf\u0026Expires=1732779776\u0026Signature=OWGEp1EbAFW6-YCbvxVRXnttbhFrIvEvt3MLSTxhfYCsvQ7B3gq45VF3SM9DoxVv59pYXzHbDbR9lBg1hvmEMKzEeQvZ7ILL6dB1wxDeM1NbuyXuiBnppE9mTWPp6oPJpj7ATMmW-2-rC-pzDgfiD1lH0mia6YQbJgGR8~SDeuypKX7NGrd~W-rMMS~PClcK3wWPxMejhPTDKHz1aVHeJZv7BOCsa021Zz3tPSkdnQhF6TrJEbXMyx96cGxYTTrJSvyqrx1xA36~6~J6EQW-9larePBbk3Toj6hOXE2RKAJ8r0ISHHEIdhqxwfPa~NKQM4woVpo0Ua-m4oTulH1rng__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28661839"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28661839/Treatment_Failure_and_Miltefosine_Susceptibility_in_Dermal_Leishmaniasis_Caused_by_Leishmania_Subgenus_Viannia_Species"><img alt="Research paper thumbnail of Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species" class="work-thumbnail" src="https://attachments.academia-assets.com/49038713/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28661839/Treatment_Failure_and_Miltefosine_Susceptibility_in_Dermal_Leishmaniasis_Caused_by_Leishmania_Subgenus_Viannia_Species">Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania (...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania (Viannia) species are poorly understood. Prospective evaluation of drug susceptibility of strains isolated from individual patients before drug exposure and at clinical failure allows intrinsic and acquired differences in susceptibility to be discerned and analyzed. To determine whether intrinsic susceptibility or loss of susceptibility to miltefosine contributed to treatment failure, we evaluated the miltefosine susceptibility of intracellular amastigotes and promastigotes of six Leishmania (Viannia) braziliensis and six Leishmania (Viannia) panamensis strains isolated sequentially, at diagnosis and treatment failure, from two children and four adults >55 years old with concurrent conditions. Four patients presented only cutaneous lesions, one had mucosal disease, and one had disseminated mucocutaneous disease. Expression of the Leishmania drug transporter genes abca2, abca3, abcc2, abcc3, abcg4, abcg6, and LbMT was evaluated by quantitative reverse transcription-PCR (qRT-PCR). Intracellular amastigotes (median 50% effective concentration [EC 50 ], 10.7 mol/liter) were more susceptible to miltefosine than promastigotes (median EC 50 , 55.3 mol/liter) (P < 0.0001). Loss of susceptibility at failure, demonstrated by a miltefosine EC 50 of >32 mol/liter (the upper limit of intracel-lular amastigote assay), occurred in L. panamensis infection in a child and in L. braziliensis infection in an adult and was accompanied by decreased expression of the miltefosine transporter LbMT (LbMT/-tubulin, 0.42-to 0.26-fold [P 0.039] and 0.70-to 0.57-fold [P 0.009], respectively). LbMT gene polymorphisms were not associated with susceptibility phenotype. Leishma-nia ABCA3 transporter expression was inversely correlated with miltefosine susceptibility (r 0.605; P 0.037). Loss of susceptibility is one of multiple factors involved in failure of miltefosine treatment in dermal leishmaniasis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7be60831ad74028894be27c84b40fbf0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49038713,"asset_id":28661839,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49038713/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28661839"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28661839"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28661839; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28661839]").text(description); $(".js-view-count[data-work-id=28661839]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28661839; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28661839']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28661839, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7be60831ad74028894be27c84b40fbf0" } } $('.js-work-strip[data-work-id=28661839]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28661839,"title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species","translated_title":"","metadata":{"abstract":"Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania (Viannia) species are poorly understood. Prospective evaluation of drug susceptibility of strains isolated from individual patients before drug exposure and at clinical failure allows intrinsic and acquired differences in susceptibility to be discerned and analyzed. To determine whether intrinsic susceptibility or loss of susceptibility to miltefosine contributed to treatment failure, we evaluated the miltefosine susceptibility of intracellular amastigotes and promastigotes of six Leishmania (Viannia) braziliensis and six Leishmania (Viannia) panamensis strains isolated sequentially, at diagnosis and treatment failure, from two children and four adults \u003e55 years old with concurrent conditions. Four patients presented only cutaneous lesions, one had mucosal disease, and one had disseminated mucocutaneous disease. Expression of the Leishmania drug transporter genes abca2, abca3, abcc2, abcc3, abcg4, abcg6, and LbMT was evaluated by quantitative reverse transcription-PCR (qRT-PCR). Intracellular amastigotes (median 50% effective concentration [EC 50 ], 10.7 mol/liter) were more susceptible to miltefosine than promastigotes (median EC 50 , 55.3 mol/liter) (P \u003c 0.0001). Loss of susceptibility at failure, demonstrated by a miltefosine EC 50 of \u003e32 mol/liter (the upper limit of intracel-lular amastigote assay), occurred in L. panamensis infection in a child and in L. braziliensis infection in an adult and was accompanied by decreased expression of the miltefosine transporter LbMT (LbMT/-tubulin, 0.42-to 0.26-fold [P 0.039] and 0.70-to 0.57-fold [P 0.009], respectively). LbMT gene polymorphisms were not associated with susceptibility phenotype. Leishma-nia ABCA3 transporter expression was inversely correlated with miltefosine susceptibility (r 0.605; P 0.037). Loss of susceptibility is one of multiple factors involved in failure of miltefosine treatment in dermal leishmaniasis."},"translated_abstract":"Treatment failure and parasite drug susceptibility in dermal leishmaniasis caused by Leishmania (Viannia) species are poorly understood. Prospective evaluation of drug susceptibility of strains isolated from individual patients before drug exposure and at clinical failure allows intrinsic and acquired differences in susceptibility to be discerned and analyzed. To determine whether intrinsic susceptibility or loss of susceptibility to miltefosine contributed to treatment failure, we evaluated the miltefosine susceptibility of intracellular amastigotes and promastigotes of six Leishmania (Viannia) braziliensis and six Leishmania (Viannia) panamensis strains isolated sequentially, at diagnosis and treatment failure, from two children and four adults \u003e55 years old with concurrent conditions. Four patients presented only cutaneous lesions, one had mucosal disease, and one had disseminated mucocutaneous disease. Expression of the Leishmania drug transporter genes abca2, abca3, abcc2, abcc3, abcg4, abcg6, and LbMT was evaluated by quantitative reverse transcription-PCR (qRT-PCR). Intracellular amastigotes (median 50% effective concentration [EC 50 ], 10.7 mol/liter) were more susceptible to miltefosine than promastigotes (median EC 50 , 55.3 mol/liter) (P \u003c 0.0001). Loss of susceptibility at failure, demonstrated by a miltefosine EC 50 of \u003e32 mol/liter (the upper limit of intracel-lular amastigote assay), occurred in L. panamensis infection in a child and in L. braziliensis infection in an adult and was accompanied by decreased expression of the miltefosine transporter LbMT (LbMT/-tubulin, 0.42-to 0.26-fold [P 0.039] and 0.70-to 0.57-fold [P 0.009], respectively). LbMT gene polymorphisms were not associated with susceptibility phenotype. Leishma-nia ABCA3 transporter expression was inversely correlated with miltefosine susceptibility (r 0.605; P 0.037). Loss of susceptibility is one of multiple factors involved in failure of miltefosine treatment in dermal leishmaniasis.","internal_url":"https://www.academia.edu/28661839/Treatment_Failure_and_Miltefosine_Susceptibility_in_Dermal_Leishmaniasis_Caused_by_Leishmania_Subgenus_Viannia_Species","translated_internal_url":"","created_at":"2016-09-22T08:05:10.854-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52283790,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":24536811,"work_id":28661839,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":590903,"email":"l***a@cideim.org.co","display_order":1,"name":"Liliana Valderrama","title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species"},{"id":24536812,"work_id":28661839,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455921,"email":"l***o@emcali.net.co","display_order":2,"name":"Luisa Rubiano","title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species"},{"id":24536814,"work_id":28661839,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455924,"email":"n***a@gmail.com","display_order":4,"name":"Nancy Saravia","title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species"},{"id":24536815,"work_id":28661839,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":476802,"email":"s***n@cideim.org.co","display_order":5,"name":"Nancy Saravia","title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species"},{"id":24536816,"work_id":28661839,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":1607790,"email":"s***a@cideim.org.co","display_order":6,"name":"Nancy Saravia","title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species"},{"id":24536817,"work_id":28661839,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455927,"email":"l***o@cideim.org.co","display_order":7,"name":"Luisa Rubiano","title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species"},{"id":24536818,"work_id":28661839,"tagging_user_id":52283790,"tagged_user_id":36834615,"co_author_invite_id":null,"email":"m***z@med.lu.se","display_order":8,"name":"M. Gomez","title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species"},{"id":24536819,"work_id":28661839,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":476799,"email":"m***z@cideim.org.co","display_order":9,"name":"María Gómez","title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species"},{"id":24536820,"work_id":28661839,"tagging_user_id":52283790,"tagged_user_id":29893337,"co_author_invite_id":null,"email":"m***6@gmail.com","display_order":10,"name":"María Gómez","title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species"},{"id":24536821,"work_id":28661839,"tagging_user_id":52283790,"tagged_user_id":16629642,"co_author_invite_id":null,"email":"s***1@yaoo.com.ar","affiliation":"Universidad de Buenos Aires","display_order":11,"name":"maria gomez","title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species"},{"id":24536822,"work_id":28661839,"tagging_user_id":52283790,"tagged_user_id":15080159,"co_author_invite_id":null,"email":"m***8@gmail.com","display_order":12,"name":"Maria Gomez","title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species"},{"id":24536823,"work_id":28661839,"tagging_user_id":52283790,"tagged_user_id":10675300,"co_author_invite_id":null,"email":"m***f@hotmail.com","affiliation":"UTB - Universidad Tecnológica de Bolívar","display_order":13,"name":"Maria Gomez","title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species"},{"id":24536824,"work_id":28661839,"tagging_user_id":52283790,"tagged_user_id":10363757,"co_author_invite_id":null,"email":"m***5@gmail.com","display_order":14,"name":"Maria Gomez","title":"Treatment Failure and Miltefosine Susceptibility in Dermal Leishmaniasis Caused by Leishmania Subgenus Viannia Species"},{"id":24689242,"work_id":28661839,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5485607,"email":"r***a@cideim.org.co","display_order":4194311,"name":"R. 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Buenaventura, a soc...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Congenital syphilis (CS) is a major global public health<br />problem. Buenaventura, a socioeconomically deprived municipality in the<br />Colombian Pacific Coast, accounts for 6.6% of all CS cases in Colombia.<br />To begin to understand the main reasons for the high rates of the disease in<br />Buenaventura, we conducted a retrospective electronic health record analysis<br />of all infants admitted with CS during the first 7 months of 2011 to the<br />Hospital Departamental de Buenaventura, the city’s main birthing hospital.<br />Methods: The diagnosis of gestational syphilis and CS was based on a<br />predefined Colombian public health service algorithm. Clinical, laboratory,<br />and sociodemographic parameters for all infants studied, including<br />maternal access to prenatal care, syphilis serologic diagnosis, and<br />adequacy of penicillin treatment, were abstracted and analyzed.<br />Results: A total of 89 infants met the case definition for CS. Most<br />mothers (80%) were affiliated with government-regulated or private health<br />care insurance plans. While 64 (70%) of 92 attended at least 1 antenatal<br />care visit and 59 of these 64 (84%) were screened for syphilis, only<br />5 (8%) of 59 received appropriate antibiotic therapy. Although most infants<br />were asymptomatic at birth, prematurity (15/82) was common. Two<br />infants died in the neonatal period, and 5 pregnancies ended in stillbirth.<br />Conclusions: Our findings confirm that Buenaventura has a very high<br />incidence of CS and demonstrate that existing antenatal care gestational<br />syphilis programs are flawed. Prevention strategies should emphasize enhanced<br />early syphilis screening in pregnancy, preferably through the<br />implementation of point-of-care testing in the community and same-day<br />treatment with at least 1 dose of penicillin.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a2e9ccfe390c412fe7a7ccb633bd10b2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49038692,"asset_id":28661807,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49038692/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28661807"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28661807"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28661807; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28661807]").text(description); $(".js-view-count[data-work-id=28661807]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28661807; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28661807']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28661807, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a2e9ccfe390c412fe7a7ccb633bd10b2" } } $('.js-work-strip[data-work-id=28661807]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28661807,"title":"Gestational and Congenital Syphilis Epidemic in the Colombian Pacific Coast","translated_title":"","metadata":{"abstract":"Background: Congenital syphilis (CS) is a major global public health\nproblem. Buenaventura, a socioeconomically deprived municipality in the\nColombian Pacific Coast, accounts for 6.6% of all CS cases in Colombia.\nTo begin to understand the main reasons for the high rates of the disease in\nBuenaventura, we conducted a retrospective electronic health record analysis\nof all infants admitted with CS during the first 7 months of 2011 to the\nHospital Departamental de Buenaventura, the city’s main birthing hospital.\nMethods: The diagnosis of gestational syphilis and CS was based on a\npredefined Colombian public health service algorithm. Clinical, laboratory,\nand sociodemographic parameters for all infants studied, including\nmaternal access to prenatal care, syphilis serologic diagnosis, and\nadequacy of penicillin treatment, were abstracted and analyzed.\nResults: A total of 89 infants met the case definition for CS. Most\nmothers (80%) were affiliated with government-regulated or private health\ncare insurance plans. While 64 (70%) of 92 attended at least 1 antenatal\ncare visit and 59 of these 64 (84%) were screened for syphilis, only\n5 (8%) of 59 received appropriate antibiotic therapy. Although most infants\nwere asymptomatic at birth, prematurity (15/82) was common. Two\ninfants died in the neonatal period, and 5 pregnancies ended in stillbirth.\nConclusions: Our findings confirm that Buenaventura has a very high\nincidence of CS and demonstrate that existing antenatal care gestational\nsyphilis programs are flawed. Prevention strategies should emphasize enhanced\nearly syphilis screening in pregnancy, preferably through the\nimplementation of point-of-care testing in the community and same-day\ntreatment with at least 1 dose of penicillin."},"translated_abstract":"Background: Congenital syphilis (CS) is a major global public health\nproblem. Buenaventura, a socioeconomically deprived municipality in the\nColombian Pacific Coast, accounts for 6.6% of all CS cases in Colombia.\nTo begin to understand the main reasons for the high rates of the disease in\nBuenaventura, we conducted a retrospective electronic health record analysis\nof all infants admitted with CS during the first 7 months of 2011 to the\nHospital Departamental de Buenaventura, the city’s main birthing hospital.\nMethods: The diagnosis of gestational syphilis and CS was based on a\npredefined Colombian public health service algorithm. Clinical, laboratory,\nand sociodemographic parameters for all infants studied, including\nmaternal access to prenatal care, syphilis serologic diagnosis, and\nadequacy of penicillin treatment, were abstracted and analyzed.\nResults: A total of 89 infants met the case definition for CS. Most\nmothers (80%) were affiliated with government-regulated or private health\ncare insurance plans. While 64 (70%) of 92 attended at least 1 antenatal\ncare visit and 59 of these 64 (84%) were screened for syphilis, only\n5 (8%) of 59 received appropriate antibiotic therapy. Although most infants\nwere asymptomatic at birth, prematurity (15/82) was common. Two\ninfants died in the neonatal period, and 5 pregnancies ended in stillbirth.\nConclusions: Our findings confirm that Buenaventura has a very high\nincidence of CS and demonstrate that existing antenatal care gestational\nsyphilis programs are flawed. Prevention strategies should emphasize enhanced\nearly syphilis screening in pregnancy, preferably through the\nimplementation of point-of-care testing in the community and same-day\ntreatment with at least 1 dose of penicillin.","internal_url":"https://www.academia.edu/28661807/Gestational_and_Congenital_Syphilis_Epidemic_in_the_Colombian_Pacific_Coast","translated_internal_url":"","created_at":"2016-09-22T08:03:39.769-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52283790,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":24536803,"work_id":28661807,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455930,"email":"m***n@cideim.org.co","display_order":1,"name":"Maria Castrillón","title":"Gestational and Congenital Syphilis Epidemic in the Colombian Pacific Coast"},{"id":24536805,"work_id":28661807,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455931,"email":"m***o@valledelcauca.gov.co","display_order":3,"name":"Martha Castaño","title":"Gestational and Congenital Syphilis Epidemic in the Colombian Pacific Coast"},{"id":24536806,"work_id":28661807,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455932,"email":"s***n@att.net","display_order":4,"name":"Juan Salazar","title":"Gestational and Congenital Syphilis Epidemic in the Colombian Pacific Coast"},{"id":24537204,"work_id":28661807,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455980,"email":"a***z@cideim.org.co","display_order":4194306,"name":"Adriana Cruz","title":"Gestational and Congenital Syphilis Epidemic in the Colombian Pacific Coast"}],"downloadable_attachments":[{"id":49038692,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49038692/thumbnails/1.jpg","file_name":"Gestational_and_Congenital_Syphilis_Epidemic_in_the.pdf","download_url":"https://www.academia.edu/attachments/49038692/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Gestational_and_Congenital_Syphilis_Epid.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49038692/Gestational_and_Congenital_Syphilis_Epidemic_in_the-libre.pdf?1474556734=\u0026response-content-disposition=attachment%3B+filename%3DGestational_and_Congenital_Syphilis_Epid.pdf\u0026Expires=1732779776\u0026Signature=Cnb9kqSKKDmJLGA5Kf4S87FJRv8ZaMj1rc1mYz-oDPH-GDQGZv0fIj8BqJWmbaptd7JNopweZqLRV61DUBE~e25HSAzH5~52O6GguK5IT5ppuogO~oMfTqZwscod013iCDB4bgW40R1Fs5~B2uHHB7Edv9BUGf9eof6t32rcucQSPhv8Fer-TrQHFDX5n1ZQxUZg1mCycLroBK5lDqcvataOWFuvqh4IesskVs7KS6Nm9nXfTfaW46EvZv0OXtLR9t1nzV5UgywhOOCzzPXYA~ywlmc0xPOEs74XKo9fDFLaYgHRP19FEj66jGhczJ4bxgB0K3twyyrpjwEXrXeJ6A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Gestational_and_Congenital_Syphilis_Epidemic_in_the_Colombian_Pacific_Coast","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":52283790,"first_name":"Luisa Consuelo","middle_initials":"","last_name":"Rubiano Perea","page_name":"LRubianoPerea","domain_name":"javerianacali","created_at":"2016-08-20T06:55:56.486-07:00","display_name":"Luisa Consuelo Rubiano Perea","url":"https://javerianacali.academia.edu/LRubianoPerea"},"attachments":[{"id":49038692,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49038692/thumbnails/1.jpg","file_name":"Gestational_and_Congenital_Syphilis_Epidemic_in_the.pdf","download_url":"https://www.academia.edu/attachments/49038692/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Gestational_and_Congenital_Syphilis_Epid.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49038692/Gestational_and_Congenital_Syphilis_Epidemic_in_the-libre.pdf?1474556734=\u0026response-content-disposition=attachment%3B+filename%3DGestational_and_Congenital_Syphilis_Epid.pdf\u0026Expires=1732779776\u0026Signature=Cnb9kqSKKDmJLGA5Kf4S87FJRv8ZaMj1rc1mYz-oDPH-GDQGZv0fIj8BqJWmbaptd7JNopweZqLRV61DUBE~e25HSAzH5~52O6GguK5IT5ppuogO~oMfTqZwscod013iCDB4bgW40R1Fs5~B2uHHB7Edv9BUGf9eof6t32rcucQSPhv8Fer-TrQHFDX5n1ZQxUZg1mCycLroBK5lDqcvataOWFuvqh4IesskVs7KS6Nm9nXfTfaW46EvZv0OXtLR9t1nzV5UgywhOOCzzPXYA~ywlmc0xPOEs74XKo9fDFLaYgHRP19FEj66jGhczJ4bxgB0K3twyyrpjwEXrXeJ6A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1088,"name":"Infectious disease epidemiology","url":"https://www.academia.edu/Documents/in/Infectious_disease_epidemiology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28661789"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28661789/Noninferiority_of_Miltefosine_Versus_Meglumine_Antimoniate_for_Cutaneous_Leishmaniasis_in_Children"><img alt="Research paper thumbnail of Noninferiority of Miltefosine Versus Meglumine Antimoniate for Cutaneous Leishmaniasis in Children" class="work-thumbnail" src="https://attachments.academia-assets.com/49038672/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28661789/Noninferiority_of_Miltefosine_Versus_Meglumine_Antimoniate_for_Cutaneous_Leishmaniasis_in_Children">Noninferiority of Miltefosine Versus Meglumine Antimoniate for Cutaneous Leishmaniasis in Children</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://javerianacali.academia.edu/LRubianoPerea">Luisa Consuelo Rubiano Perea</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/IsabelBarraquer">Isabel Barraquer</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LydaOsorio">Lyda Osorio</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background. Children have a lower response rate to antimonial drugs and higher elimination rate o...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background. Children have a lower response rate to antimonial drugs and higher elimination rate of antimony<br />(Sb) than adults. Oral miltefosine has not been evaluated for pediatric cutaneous leishmaniasis.<br />Methods. A randomized, noninferiority clinical trial with masked evaluation was conducted at 3 locations in<br />Colombia where Leishmania panamensis and Leishmania guyanensis predominated. One hundred sixteen children<br />aged 2–12 years with parasitologically confirmed cutaneous leishmaniasis were randomized to directly observed<br />treatment with meglumine antimoniate (20 mg Sb/kg/d for 20 days; intramuscular) (n 5 58) or miltefosine (1.8–<br />2.5 mg/kg/d for 28 days; by mouth) (n 5 58). Primary outcome was treatment failure at or before week 26 after<br />initiation of treatment. Miltefosine was noninferior if the proportion of treatment failures was #15% higher than<br />achieved with meglumine antimoniate (1-sided test, a 5 .05).<br />Results. Ninety-five percent of children (111/116) completed follow-up evaluation. By intention-to-treat analysis,<br />failure rate was 17.2% (98% confidence interval [CI], 5.7%–28.7%) for miltefosine and 31% (98% CI, 16.9%–45.2%)<br />for meglumine antimoniate. The difference between treatment groups was 13.8%, (98% CI, 24.5% to 32%)<br />(P 5 .04). Adverse events were mild for both treatments.<br />Conclusions. Miltefosine is noninferior to meglumine antimoniate for treatment of pediatric cutaneous<br />leishmaniasis caused by Leishmania (Viannia) species. Advantages of oral administration and low toxicity favor<br />use of miltefosine in children.<br />Clinical Trial Registration. NCT00487253.<br />Internal</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eb95ff1f29e5a611ae7bd170c6cf2189" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49038672,"asset_id":28661789,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49038672/download_file?st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc3NjE3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28661789"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28661789"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28661789; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28661789]").text(description); $(".js-view-count[data-work-id=28661789]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28661789; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28661789']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28661789, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "eb95ff1f29e5a611ae7bd170c6cf2189" } } $('.js-work-strip[data-work-id=28661789]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28661789,"title":"Noninferiority of Miltefosine Versus Meglumine Antimoniate for Cutaneous Leishmaniasis in Children","translated_title":"","metadata":{"abstract":"Background. Children have a lower response rate to antimonial drugs and higher elimination rate of antimony\n(Sb) than adults. Oral miltefosine has not been evaluated for pediatric cutaneous leishmaniasis.\nMethods. A randomized, noninferiority clinical trial with masked evaluation was conducted at 3 locations in\nColombia where Leishmania panamensis and Leishmania guyanensis predominated. One hundred sixteen children\naged 2–12 years with parasitologically confirmed cutaneous leishmaniasis were randomized to directly observed\ntreatment with meglumine antimoniate (20 mg Sb/kg/d for 20 days; intramuscular) (n 5 58) or miltefosine (1.8–\n2.5 mg/kg/d for 28 days; by mouth) (n 5 58). Primary outcome was treatment failure at or before week 26 after\ninitiation of treatment. Miltefosine was noninferior if the proportion of treatment failures was #15% higher than\nachieved with meglumine antimoniate (1-sided test, a 5 .05).\nResults. Ninety-five percent of children (111/116) completed follow-up evaluation. By intention-to-treat analysis,\nfailure rate was 17.2% (98% confidence interval [CI], 5.7%–28.7%) for miltefosine and 31% (98% CI, 16.9%–45.2%)\nfor meglumine antimoniate. The difference between treatment groups was 13.8%, (98% CI, 24.5% to 32%)\n(P 5 .04). Adverse events were mild for both treatments.\nConclusions. Miltefosine is noninferior to meglumine antimoniate for treatment of pediatric cutaneous\nleishmaniasis caused by Leishmania (Viannia) species. Advantages of oral administration and low toxicity favor\nuse of miltefosine in children.\nClinical Trial Registration. NCT00487253.\nInternal"},"translated_abstract":"Background. Children have a lower response rate to antimonial drugs and higher elimination rate of antimony\n(Sb) than adults. Oral miltefosine has not been evaluated for pediatric cutaneous leishmaniasis.\nMethods. A randomized, noninferiority clinical trial with masked evaluation was conducted at 3 locations in\nColombia where Leishmania panamensis and Leishmania guyanensis predominated. One hundred sixteen children\naged 2–12 years with parasitologically confirmed cutaneous leishmaniasis were randomized to directly observed\ntreatment with meglumine antimoniate (20 mg Sb/kg/d for 20 days; intramuscular) (n 5 58) or miltefosine (1.8–\n2.5 mg/kg/d for 28 days; by mouth) (n 5 58). Primary outcome was treatment failure at or before week 26 after\ninitiation of treatment. Miltefosine was noninferior if the proportion of treatment failures was #15% higher than\nachieved with meglumine antimoniate (1-sided test, a 5 .05).\nResults. Ninety-five percent of children (111/116) completed follow-up evaluation. By intention-to-treat analysis,\nfailure rate was 17.2% (98% confidence interval [CI], 5.7%–28.7%) for miltefosine and 31% (98% CI, 16.9%–45.2%)\nfor meglumine antimoniate. The difference between treatment groups was 13.8%, (98% CI, 24.5% to 32%)\n(P 5 .04). Adverse events were mild for both treatments.\nConclusions. Miltefosine is noninferior to meglumine antimoniate for treatment of pediatric cutaneous\nleishmaniasis caused by Leishmania (Viannia) species. Advantages of oral administration and low toxicity favor\nuse of miltefosine in children.\nClinical Trial Registration. NCT00487253.\nInternal","internal_url":"https://www.academia.edu/28661789/Noninferiority_of_Miltefosine_Versus_Meglumine_Antimoniate_for_Cutaneous_Leishmaniasis_in_Children","translated_internal_url":"","created_at":"2016-09-22T08:01:19.310-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52283790,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":24536770,"work_id":28661789,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5455921,"email":"l***o@emcali.net.co","display_order":1,"name":"Luisa Rubiano","title":"Noninferiority of Miltefosine Versus Meglumine Antimoniate for Cutaneous Leishmaniasis in Children"},{"id":24536771,"work_id":28661789,"tagging_user_id":52283790,"tagged_user_id":null,"co_author_invite_id":5109472,"email":"c***o@cideim.org.co","display_order":2,"name":"María Miranda","title":"Noninferiority of Miltefosine Versus Meglumine Antimoniate for Cutaneous Leishmaniasis in 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