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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="FOx6PC1/TvmgmHDbYRuUrTOXePwuRfbnWeu8EzY1s+S+FJmUnFgwhrYRzo+S1M3WKqxOPmDV+zOIsYUxXbwicQ==" /> <meta name="citation_title" content="Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony" /> <meta name="citation_author" content="Luisa Consuelo Rubiano Perea" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/28662230/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony" /> <meta name="twitter:title" content="Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony" /> <meta name="twitter:description" content="For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a" /> <meta name="twitter:image" content="https://0.academia-photos.com/52283790/14202204/19677946/s200_luisa_consuelo.rubiano_perea.jpg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/28662230/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony" /> <meta property="og:title" content="Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a" /> <meta property="article:author" content="https://javerianacali.academia.edu/LRubianoPerea" /> <meta name="description" content="For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a" /> <title>(PDF) Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony | Luisa Consuelo Rubiano Perea - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/28662230/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '9387f500ddcbb8d05c67bef28a2fe0334f1aafb8'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1733016452000); window.Aedu.timeDifference = new Date().getTime() - 1733016452000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sb v revealed that a common pathway (glutathione) may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb v , and SCC. Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sb v caused the SCC.","author":[{"@context":"https://schema.org","@type":"Person","name":"Luisa Consuelo Rubiano Perea"}],"contributor":[],"dateCreated":"2016-09-22","dateModified":null,"datePublished":null,"headline":"Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony","inLanguage":"en","keywords":[],"locationCreated":null,"publication":null,"publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/28662230/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"javerianacali"}]}</script><link rel="stylesheet" media="all" 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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F28662230%2FCase_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F28662230%2FCase_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":49039226,"identifier":"Attachment_49039226","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":28662230,"created_at":"2016-09-22T08:25:56.348-07:00","from_world_paper_id":null,"updated_at":"2021-04-01T13:36:25.073-07:00","_data":{"abstract":"For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sb v revealed that a common pathway (glutathione) may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb v , and SCC. Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sb v caused the SCC."},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony","broadcastable":true,"draft":false,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [52283790]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":49039226,"attachmentType":"pdf"}"><img alt="First page of “Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/49039226/mini_magick20190201-25014-15qb5q5.png?1549074661" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Case Report: Possible Links between Sickle Cell Crisis and Pentavalent Antimony</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="52283790" href="https://javerianacali.academia.edu/LRubianoPerea"><img alt="Profile image of Luisa Consuelo Rubiano Perea" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/52283790/14202204/19677946/s65_luisa_consuelo.rubiano_perea.jpg" />Luisa Consuelo Rubiano Perea</a></div><div class="ds-work-card--detail"></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">For over 60 years, pentavalent antimony (Sb v) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sb v revealed that a common pathway (glutathione) may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb v , and SCC. Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sb v caused the SCC.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":49039226,"attachmentType":"pdf","workUrl":"https://www.academia.edu/28662230/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":49039226,"attachmentType":"pdf","workUrl":"https://www.academia.edu/28662230/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="49039226" data-landing_url="https://www.academia.edu/28662230/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="38300406" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/38300406/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony_pdf">Case Report Possible Links between Sickle Cell Crisis and Pentavalent Antimony.pdf</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="52220738" href="https://javerianacali.academia.edu/LuisaConsueloRubianoPerea">Luisa Consuelo Rubiano Perea</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Am. J. Trop. Med. Hyg.,, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">Abstract. For over 60 years, pentavalent antimony (Sbv) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sbv revealed that a common pathway (glutathione) may have resulted in the SCC. ChemoText, a novel database created to predict chemical-proteindisease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sbv, and SCC. Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sbv caused the SCC.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Case Report Possible Links between Sickle Cell Crisis and Pentavalent Antimony.pdf","attachmentId":58348153,"attachmentType":"pdf","work_url":"https://www.academia.edu/38300406/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony_pdf","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/38300406/Case_Report_Possible_Links_between_Sickle_Cell_Crisis_and_Pentavalent_Antimony_pdf"><span 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data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/22147800/Antimony_in_plasma_and_skin_of_patients_with_cutaneous_leishmaniasis_relationship_with_side_effects_after_treatment_with_meglumine_antimoniate">Antimony in plasma and skin of patients with cutaneous leishmaniasis �� relationship with side effects after treatment with meglumine antimoniate</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33138764" href="https://brasilia.academia.edu/EloisaCaldas">Eloisa Caldas</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Tropical Medicine & International Health, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Antimony in plasma and skin of patients with cutaneous 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js-wsj-grid-card" data-collection-position="3" data-entity-id="4717077" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4717077/Pharmacokinetics_of_Antimony_in_Children_Treated_for_Leishmaniasis_with_Meglumine_Antimoniate">Pharmacokinetics of Antimony in Children Treated for Leishmaniasis with Meglumine Antimoniate</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="6026745" href="https://independent.academia.edu/AdrianaCruz3">Adriana Cruz</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Infectious Diseases, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Pharmacokinetics of Antimony in Children Treated for Leishmaniasis with Meglumine Antimoniate","attachmentId":49669104,"attachmentType":"pdf","work_url":"https://www.academia.edu/4717077/Pharmacokinetics_of_Antimony_in_Children_Treated_for_Leishmaniasis_with_Meglumine_Antimoniate","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/4717077/Pharmacokinetics_of_Antimony_in_Children_Treated_for_Leishmaniasis_with_Meglumine_Antimoniate"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="108811450" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/108811450/Malaria_chemoprophylaxis_in_sickle_cell_disease">Malaria chemoprophylaxis in sickle cell disease</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32017469" href="https://nationalhospitalabuja.academia.edu/OluseyiOniyangi">Oluseyi Oniyangi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Cochrane library, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Malaria chemoprophylaxis in sickle cell disease","attachmentId":107102915,"attachmentType":"pdf","work_url":"https://www.academia.edu/108811450/Malaria_chemoprophylaxis_in_sickle_cell_disease","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/108811450/Malaria_chemoprophylaxis_in_sickle_cell_disease"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="67464608" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/67464608/Sickle_Cell_Disease_Targeted_Pathways_of_Antisickling_Products">Sickle Cell Disease: Targeted Pathways of Antisickling Products</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="112528179" href="https://uyi-uninet.academia.edu/KOTUETAPTUECharles">KOTUE TAPTUE Charles</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2016</p><p class="ds-related-work--abstract ds2-5-body-sm">We present in this study a theoretical review of Sickle Cell Disease (SCD), highlighting on the pathophysiology and targeted pathways of antisickling products. Sickle cell disease (SCD) is one of the most common genetic disorders worldwide. It is caused by a point mutation that changes glutamic acid (Glu6) to valine (Val6) in the β chain of hemoglobin. This change has many damages: polymerization of abnormal haemoglobin HbS when oxygen tension decreases; red blood cell membrane deformability and cell-to-cell adherence, adhesion of sickle red blood cells to the endothelium, high production of reactive oxygen species (ROS), decreasing lactate dehydrogenase activity and Fe 2+ /Fe 3+ ratio of HbS. Understanding polymerization and pathophysiological of SCD constitute a therapeutic strategy base in the pharmacology research of this molecular disease.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Sickle Cell Disease: Targeted Pathways of Antisickling Products","attachmentId":78272104,"attachmentType":"pdf","work_url":"https://www.academia.edu/67464608/Sickle_Cell_Disease_Targeted_Pathways_of_Antisickling_Products","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/67464608/Sickle_Cell_Disease_Targeted_Pathways_of_Antisickling_Products"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="13443645" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13443645/Molecular_Basis_of_Antimony_Treatment_in_Leishmaniasis_">Molecular Basis of Antimony Treatment in Leishmaniasis †</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32666696" href="https://independent.academia.edu/AndreaIlari">Andrea Ilari</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Medicinal Chemistry, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Molecular Basis of Antimony Treatment in Leishmaniasis †","attachmentId":45337688,"attachmentType":"pdf","work_url":"https://www.academia.edu/13443645/Molecular_Basis_of_Antimony_Treatment_in_Leishmaniasis_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13443645/Molecular_Basis_of_Antimony_Treatment_in_Leishmaniasis_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="61420251" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/61420251/Antimony_Containing_Drug_and_ECG_Abnormalities_in_Children_with_Visceral_Leishmaniasis">Antimony Containing Drug and ECG Abnormalities in Children with Visceral Leishmaniasis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="205511952" href="https://independent.academia.edu/LOURDESZANONI">LOURDES ZANONI</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biological Trace Element Research, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">The objective of the paper was to evaluate the influence of antimony (5+) on electrocardiographic changes in children with visceral leishmaniasis. The study was based on weekly ECGs analysis of 87 children treated, from April 2001 to May 2006, with antimoniate N-methyl glucamine. Eligible subjects included children from 6 months to 12 years of age with weight of 6–34 kg. Forty-five children (52%) were males and forty-two (48%) were females. The cardiac response to antimony was significantly milder compared to the adult populations, so the usage of meglumine antimoniate is safer. Thus, during treatment sinus rhythm was maintained without ectopic beats. No changes were observed in the P wave and in PR interval. The QRS complex remained unaltered during the treatment, the amplitude being increased. The Sokolow`s indexes exceeded normal values in one child on the first week and in eight children on the fourth. The prolongation of QTc occurred in ten patients. The T wave flattening was o...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Antimony Containing Drug and ECG Abnormalities in Children with Visceral Leishmaniasis","attachmentId":74455096,"attachmentType":"pdf","work_url":"https://www.academia.edu/61420251/Antimony_Containing_Drug_and_ECG_Abnormalities_in_Children_with_Visceral_Leishmaniasis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/61420251/Antimony_Containing_Drug_and_ECG_Abnormalities_in_Children_with_Visceral_Leishmaniasis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="36183028" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/36183028/Visceral_Leishmaniasis_with_Secondary_Hemophagocytosis_in_a_Sickle_Cell_Anemia_Patient">Visceral Leishmaniasis with Secondary Hemophagocytosis in a Sickle Cell Anemia Patient</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3594081" href="https://independent.academia.edu/sciepubcomSciEP">sciepub.com SciEP</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Sickle cell anemia (SCA) is one of the most common hemoglobinopathies, which is characterized by a high level of abnormal hemoglobin called hemoglobin S (Hb S). This abnormal hemoglobin results from changes in amino acids and valine instead of glutamine at the sixth position of the β globin molecule. Two affected genes are needed to develop sickle cell anemia, homozygous Hb S.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Visceral Leishmaniasis with Secondary Hemophagocytosis in a Sickle Cell Anemia Patient","attachmentId":56083071,"attachmentType":"pdf","work_url":"https://www.academia.edu/36183028/Visceral_Leishmaniasis_with_Secondary_Hemophagocytosis_in_a_Sickle_Cell_Anemia_Patient","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/36183028/Visceral_Leishmaniasis_with_Secondary_Hemophagocytosis_in_a_Sickle_Cell_Anemia_Patient"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="34708881" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/34708881/Resistance_to_Antimony_and_Treatment_Failure_in_Human_Leishmania_Viannia_Infection">Resistance to Antimony and Treatment Failure in Human Leishmania (Viannia) Infection</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="61681016" href="https://independent.academia.edu/RicardoRojas140">Ricardo Rojas</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Infectious Diseases, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Resistance to Antimony and Treatment Failure in Human Leishmania (Viannia) Infection","attachmentId":54566423,"attachmentType":"pdf","work_url":"https://www.academia.edu/34708881/Resistance_to_Antimony_and_Treatment_Failure_in_Human_Leishmania_Viannia_Infection","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/34708881/Resistance_to_Antimony_and_Treatment_Failure_in_Human_Leishmania_Viannia_Infection"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":49039226,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":49039226,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_49039226" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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