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id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="https://donate.wikimedia.org/?wmf_source=donate&wmf_medium=sidebar&wmf_campaign=zh.wikipedia.org&uselang=zh"><span>资助维基百科</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:%E5%88%9B%E5%BB%BA%E8%B4%A6%E6%88%B7&returnto=%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6" title="我们推荐您创建账号并登录，但这不是强制性的"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>创建账号</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:%E7%94%A8%E6%88%B7%E7%99%BB%E5%BD%95&returnto=%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6" title="建议你登录，尽管并非必须。[o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>登录</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> 未登录编辑者的页面 <a href="/wiki/Help:%E6%96%B0%E6%89%8B%E5%85%A5%E9%97%A8" aria-label="了解有关编辑的更多信息"><span>了解详情</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Special:%E6%88%91%E7%9A%84%E8%B4%A1%E7%8C%AE" title="来自此IP地址的编辑列表[y]" accesskey="y"><span>贡献</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Special:%E6%88%91%E7%9A%84%E8%AE%A8%E8%AE%BA%E9%A1%B5" title="对于来自此IP地址编辑的讨论[n]" accesskey="n"><span>讨论</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="站点"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="目录" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">目录</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">移至侧栏</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">隐藏</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">序言</div> </a> </li> <li id="toc-临床应用" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#临床应用"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>临床应用</span> </div> </a> <button aria-controls="toc-临床应用-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>开关临床应用子章节</span> </button> <ul id="toc-临床应用-sublist" class="vector-toc-list"> <li id="toc-药效学" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#药效学"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>药效学</span> </div> </a> <ul id="toc-药效学-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-副作用" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#副作用"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>副作用</span> </div> </a> <ul id="toc-副作用-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-作用机制" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#作用机制"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>作用机制</span> </div> </a> <ul id="toc-作用机制-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-历史" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#历史"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>历史</span> </div> </a> <ul id="toc-历史-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-研究" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#研究"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>研究</span> </div> </a> <ul id="toc-研究-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-参考文献" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#参考文献"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>参考文献</span> </div> </a> <ul id="toc-参考文献-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-外部链接" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#外部链接"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>外部链接</span> </div> </a> <ul id="toc-外部链接-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="目录" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="开关目录" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">开关目录</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">拉替拉韦</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="前往另一种语言写成的文章。22种语言可用" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-22" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">22种语言</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%B1%D8%A7%D9%84%D8%AA%D8%BA%D8%B1%D8%A7%D9%81%D9%8A%D8%B1" title="رالتغرافير – 阿拉伯语" lang="ar" hreflang="ar" data-title="رالتغرافير" data-language-autonym="العربية" data-language-local-name="阿拉伯语" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Raltegravir" title="Raltegravir – 德语" lang="de" hreflang="de" data-title="Raltegravir" data-language-autonym="Deutsch" data-language-local-name="德语" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Raltegravir" title="Raltegravir – 英语" lang="en" hreflang="en" data-title="Raltegravir" data-language-autonym="English" data-language-local-name="英语" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Raltegravir" title="Raltegravir – 西班牙语" lang="es" hreflang="es" data-title="Raltegravir" data-language-autonym="Español" data-language-local-name="西班牙语" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Erraltegrabir" title="Erraltegrabir – 巴斯克语" lang="eu" hreflang="eu" data-title="Erraltegrabir" data-language-autonym="Euskara" data-language-local-name="巴斯克语" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%B1%D8%A7%D9%84%D8%AA%DA%AF%D8%B1%D8%A7%D9%88%DB%8C%D8%B1" title="رالتگراویر – 波斯语" lang="fa" hreflang="fa" data-title="رالتگراویر" data-language-autonym="فارسی" data-language-local-name="波斯语" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Raltegraviiri" title="Raltegraviiri – 芬兰语" lang="fi" hreflang="fi" data-title="Raltegraviiri" data-language-autonym="Suomi" data-language-local-name="芬兰语" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Ralt%C3%A9gravir" title="Raltégravir – 法语" lang="fr" hreflang="fr" data-title="Raltégravir" data-language-autonym="Français" data-language-local-name="法语" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Raltegravir" title="Raltegravir – 意大利语" lang="it" hreflang="it" data-title="Raltegravir" data-language-autonym="Italiano" data-language-local-name="意大利语" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%A9%E3%83%AB%E3%83%86%E3%82%B0%E3%83%A9%E3%83%93%E3%83%AB" title="ラルテグラビル – 日语" lang="ja" hreflang="ja" data-title="ラルテグラビル" data-language-autonym="日本語" data-language-local-name="日语" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%9E%84%ED%85%8C%EA%B7%B8%EB%9D%BC%EB%B9%8C" title="랄테그라빌 – 韩语" lang="ko" hreflang="ko" data-title="랄테그라빌" data-language-autonym="한국어" data-language-local-name="韩语" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Raltegravir" title="Raltegravir – 荷兰语" lang="nl" hreflang="nl" data-title="Raltegravir" data-language-autonym="Nederlands" data-language-local-name="荷兰语" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%B0%E0%AC%BE%E0%AC%B2%E0%AC%9F%E0%AD%87%E0%AC%97%E0%AD%8D%E0%AC%B0%E0%AC%BE%E0%AC%AD%E0%AC%BF%E0%AC%B0" title="ରାଲଟେଗ୍ରାଭିର – 奥里亚语" lang="or" hreflang="or" data-title="ରାଲଟେଗ୍ରାଭିର" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="奥里亚语" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Raltegrawir" title="Raltegrawir – 波兰语" lang="pl" hreflang="pl" data-title="Raltegrawir" data-language-autonym="Polski" data-language-local-name="波兰语" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Raltegravir" title="Raltegravir – 葡萄牙语" lang="pt" hreflang="pt" data-title="Raltegravir" data-language-autonym="Português" data-language-local-name="葡萄牙语" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A0%D0%B0%D0%BB%D1%82%D0%B5%D0%B3%D1%80%D0%B0%D0%B2%D0%B8%D1%80" title="Ралтегравир – 俄语" lang="ru" hreflang="ru" data-title="Ралтегравир" data-language-autonym="Русский" data-language-local-name="俄语" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Raltegravir" title="Raltegravir – 塞尔维亚-克罗地亚语" lang="sh" hreflang="sh" data-title="Raltegravir" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="塞尔维亚-克罗地亚语" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Raltegravir" title="Raltegravir – 斯洛文尼亚语" lang="sl" hreflang="sl" data-title="Raltegravir" data-language-autonym="Slovenščina" data-language-local-name="斯洛文尼亚语" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Raltegravir" title="Raltegravir – 塞尔维亚语" lang="sr" hreflang="sr" data-title="Raltegravir" data-language-autonym="Српски / srpski" data-language-local-name="塞尔维亚语" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Raltegravir" title="Raltegravir – 土耳其语" lang="tr" hreflang="tr" data-title="Raltegravir" data-language-autonym="Türkçe" data-language-local-name="土耳其语" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%A0%D0%B0%D0%BB%D1%82%D0%B5%D0%B3%D1%80%D0%B0%D0%B2%D1%96%D1%80" title="Ралтегравір – 乌克兰语" lang="uk" hreflang="uk" data-title="Ралтегравір" data-language-autonym="Українська" data-language-local-name="乌克兰语" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Raltegravir" title="Raltegravir – 越南语" lang="vi" hreflang="vi" data-title="Raltegravir" data-language-autonym="Tiếng Việt" data-language-local-name="越南语" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q421552#sitelinks-wikipedia" title="编辑跨语言链接" class="wbc-editpage">编辑链接</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="命名空间"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6" title="浏览条目正文[c]" accesskey="c"><span>条目</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a 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mw-portlet-electronpdfservice-sidebar-portlet-heading" > <div class="vector-menu-heading"> 打印/导出 </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="electron-print_pdf" class="mw-list-item"><a href="/w/index.php?title=Special:DownloadAsPdf&page=%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6&action=show-download-screen"><span>下载为PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="javascript:print();" rel="alternate" title="本页面的可打印版本[p]" accesskey="p"><span>打印页面</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> 在其他项目中 </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="wb-otherproject-link wb-otherproject-commons mw-list-item"><a href="https://commons.wikimedia.org/wiki/Category:Raltegravir" hreflang="en"><span>维基共享资源</span></a></li><li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q421552" title="链接到连接的数据仓库项目[g]" accesskey="g"><span>维基数据项目</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="页面工具"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="外观"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">外观</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">移至侧栏</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">隐藏</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">维基百科，自由的百科全书</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="zh" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r84833064">.mw-parser-output .hatnote{font-size:small}.mw-parser-output div.hatnote{padding-left:2em;margin-bottom:0.8em;margin-top:0.8em}.mw-parser-output .hatnote-notice-img::after{content:"\202f \202f \202f \202f "}.mw-parser-output .hatnote-notice-img-small::after{content:"\202f \202f "}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}body.skin-minerva .mw-parser-output .hatnote-notice-img,body.skin-minerva .mw-parser-output .hatnote-notice-img-small{display:none}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable selfref"><span typeof="mw:File"><a href="/wiki/File:Star_of_life_caution.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d5/Star_of_life_caution.svg/20px-Star_of_life_caution.svg.png" decoding="async" width="20" height="18" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d5/Star_of_life_caution.svg/30px-Star_of_life_caution.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d5/Star_of_life_caution.svg/40px-Star_of_life_caution.svg.png 2x" data-file-width="210" data-file-height="190" /></a></span> <a href="/wiki/%E7%BB%B4%E5%9F%BA%E7%99%BE%E7%A7%91" title="维基百科">维基百科</a>中的醫學内容<b>仅供参考</b>，並<b>不能</b>視作專業意見。如需獲取醫療幫助或意見，请咨询专业人士。詳見<b><a href="/wiki/Wikipedia:%E5%8C%BB%E5%AD%A6%E5%A3%B0%E6%98%8E" title="Wikipedia:医学声明">醫學聲明</a></b>。</div> <style data-mw-deduplicate="TemplateStyles:r83732082">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}body.skin-minerva .mw-parser-output .infobox-header,body.skin-minerva .mw-parser-output .infobox-subheader,body.skin-minerva .mw-parser-output .infobox-above,body.skin-minerva .mw-parser-output .infobox-title,body.skin-minerva .mw-parser-output .infobox-image,body.skin-minerva .mw-parser-output .infobox-full-data,body.skin-minerva .mw-parser-output .infobox-below{text-align:center}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}html.skin-theme-clientpref-night .mw-parser-output .infobox td div:not(.notheme)[style]{background:transparent!important;color:var(--color-base,#202122)}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox td div:not(.notheme)[style]{background:transparent!important;color:var(--color-base,#202122)}}html.skin-theme-clientpref-night .mw-parser-output .infobox td div.NavHead:not(.notheme)[style]{background:transparent!important}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox td div.NavHead:not(.notheme)[style]{background:transparent!important}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="國際非專利藥名（INN）：拉替拉韦">拉替拉韦</span></caption><tbody><tr><td colspan="2" class="infobox-image"><span typeof="mw:File"><a href="/wiki/File:Raltegravir_structure.svg" class="mw-file-description" title="2"><img alt="2" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/41/Raltegravir_structure.svg/290px-Raltegravir_structure.svg.png" decoding="async" width="290" height="97" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/41/Raltegravir_structure.svg/435px-Raltegravir_structure.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/41/Raltegravir_structure.svg/580px-Raltegravir_structure.svg.png 2x" data-file-width="816" data-file-height="274" /></a></span></td></tr><tr><td colspan="2" class="infobox-image"><span typeof="mw:File"><a href="/wiki/File:Raltegravir-3D-balls.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/46/Raltegravir-3D-balls.png/290px-Raltegravir-3D-balls.png" decoding="async" width="290" height="108" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/46/Raltegravir-3D-balls.png/435px-Raltegravir-3D-balls.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/46/Raltegravir-3D-balls.png/580px-Raltegravir-3D-balls.png 2x" data-file-width="2693" data-file-height="1000" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;">臨床資料</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><span class="ilh-all" data-orig-title="藥物命名法" data-lang-code="en" data-lang-name="英语" data-foreign-title="Drug nomenclature"><span class="ilh-page"><a href="/w/index.php?title=%E8%97%A5%E7%89%A9%E5%91%BD%E5%90%8D%E6%B3%95&action=edit&redlink=1" class="new" title="藥物命名法（页面不存在）">商品名</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Drug_nomenclature" class="extiw" title="en:Drug nomenclature"><span lang="en" dir="auto">Drug nomenclature</span></a></span>）</span></span></th><td class="infobox-data" style="">艾生特（Isentress）</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E7%BE%8E%E5%9C%8B%E8%A1%9B%E7%94%9F%E7%B3%BB%E7%B5%B1%E8%97%A5%E5%B8%AB%E5%8D%94%E6%9C%83" title="美國衛生系統藥師協會">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data" style=""><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/raltegravir-potassium.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data" style=""><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a608004.html">a608004</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E9%86%AB%E7%99%82%E7%94%A2%E5%93%81%E6%B3%95%E5%BE%8B%E8%A6%8F%E7%AF%84" title="醫療產品法律規範">核准狀況</a></th><td class="infobox-data" style=""><div class="plainlist"> <ul><li><small><abbr title="欧盟">歐</abbr></small> <a href="/wiki/%E6%AC%A7%E6%B4%B2%E8%8D%AF%E5%93%81%E7%AE%A1%E7%90%86%E5%B1%80" title="欧洲药品管理局">EMA</a>: <span title="www.ema.europa.eu"><a rel="nofollow" class="external text" href="http://www.ema.europa.eu/ema/index.jsp?curl=%2Fpages%2Fmedicines%2Flanding%2Fepar_search.jsp&mid=&searchTab=searchByKey&alreadyLoaded=true&isNewQuery=true&status=Authorised&status=Withdrawn&status=Suspended&status=Refused&keywordSearch=Submit&searchType=name&taxonomyPath=&treeNumber=&searchGenericType=generics&keyword=yes">yes</a></span></li> <li><small><abbr title="美国">美</abbr></small> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=Raltegravir">Raltegravir</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E6%87%B7%E5%AD%95%E5%88%86%E7%B4%9A" title="懷孕分級">懷孕分級</a></th><td class="infobox-data" style=""><div class="plainlist"> <ul><li><small><abbr title="澳大利亚">澳</abbr>:</small> <a href="/wiki/%E6%87%B7%E5%AD%95%E5%88%86%E7%B4%9A#澳洲" title="懷孕分級">B3</a> </li> <li class="mw-empty-elt"></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E7%BB%99%E8%8D%AF%E9%80%94%E5%BE%84" title="给药途径">给药途径</a></th><td class="infobox-data" style="">口服</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E8%A7%A3%E5%89%96%E5%AD%A6%E6%B2%BB%E7%96%97%E5%AD%A6%E5%8F%8A%E5%8C%96%E5%AD%A6%E5%88%86%E7%B1%BB%E7%B3%BB%E7%BB%9F" title="解剖学治疗学及化学分类系统">ATC碼</a></th><td class="infobox-data" style=""><style data-mw-deduplicate="TemplateStyles:r82655520">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"><ul><li><a href="/wiki/ATC%E4%BB%A3%E7%A0%81_(J05)" title="ATC代码 (J05)">J05AJ01</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=J05AJ01">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;">法律規範狀態</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E9%86%AB%E7%99%82%E7%94%A2%E5%93%81%E6%B3%95%E5%BE%8B%E8%A6%8F%E7%AF%84" title="醫療產品法律規範">法律規範</a></th><td class="infobox-data" style=""><div class="plainlist"> <ul><li><small><abbr title="中国大陆">中</abbr>：</small><a href="/wiki/%E8%99%95%E6%96%B9%E8%97%A5" title="處方藥">处方药</a> <span typeof="mw:File"><a href="/wiki/File:Chinese_sign_for_prescription_drug.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/83/Chinese_sign_for_prescription_drug.png/30px-Chinese_sign_for_prescription_drug.png" decoding="async" width="30" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/83/Chinese_sign_for_prescription_drug.png/45px-Chinese_sign_for_prescription_drug.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/83/Chinese_sign_for_prescription_drug.png/60px-Chinese_sign_for_prescription_drug.png 2x" data-file-width="460" data-file-height="217" /></a></span></li> <li><small><abbr title="欧盟">歐</abbr>：</small>Rx-only</li> <li><small><abbr title="英国">英</abbr>：</small><a href="/wiki/%E8%99%95%E6%96%B9%E8%97%A5" title="處方藥">处方药（<span class="Unicode">℞</span>-only）</a> (POM)</li> <li><small><abbr title="美国">美</abbr>：</small><a href="/wiki/%E8%99%95%E6%96%B9%E8%97%A5" title="處方藥">处方药（<span class="Unicode">℞</span>-only）</a></li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;"><a href="/wiki/%E8%8D%AF%E7%89%A9%E4%BB%A3%E8%B0%A2%E5%8A%A8%E5%8A%9B%E5%AD%A6" title="药物代谢动力学">藥物動力學</a>數據</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E7%94%9F%E7%89%A9%E5%88%A9%E7%94%A8%E5%BA%A6" title="生物利用度">生物利用度</a></th><td class="infobox-data" style="">60%(FDA)</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E8%A1%80%E6%B5%86%E8%9B%8B%E7%99%BD%E7%BB%93%E5%90%88" title="血浆蛋白结合">血漿蛋白結合率</a></th><td class="infobox-data" style="">83%</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E8%8D%AF%E7%89%A9%E4%BB%A3%E8%B0%A2" title="药物代谢">药物代谢</a></th><td class="infobox-data" style="">肝脏代谢 (UGT1A1)</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E7%94%9F%E7%89%A9%E5%8D%8A%E8%A1%B0%E6%9C%9F" title="生物半衰期">生物半衰期</a></th><td class="infobox-data" style="">9小时</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E6%8E%92%E6%B3%84%E4%BD%9C%E7%94%A8" title="排泄作用">排泄途徑</a></th><td class="infobox-data" style="">肾脏排泄和肠道排泄</td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;">识别信息</th></tr><tr><td colspan="2" class="infobox-full-data" style=""><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC%E5%91%BD%E5%90%8D%E6%B3%95" title="IUPAC命名法">IUPAC命名法</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">N-(4-Fluorobenzyl)-5-hydroxy-1-methyl-2-(2[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino2-propanyl)-6-oxo-1,6-dihydro-4-pyrimidinecarboxamide</div></li><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;"></div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/CAS%E5%8F%B7" title="CAS号">CAS号</a></th><td class="infobox-data" style=""><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=518048-05-0">518048-05-0</a></span> <sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/PubChem" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/54671008">54671008</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB06817">DB06817</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.16445111.html">16445111</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E7%89%B9%E6%AE%8A%E6%88%90%E5%88%86%E6%A8%99%E8%AD%98" title="特殊成分標識">UNII</a></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/22VKV8053U">22VKV8053U</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D06676">D06676</a></span></li><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D07133">D07133</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:82960">CHEBI:82960</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/ChEMBL254316">ChEMBL254316</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/w/index.php?title=NIAID_ChemDB&action=edit&redlink=1" class="new" title="NIAID ChemDB（页面不存在）">NIAID ChemDB</a></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="chemdb.niaid.nih.gov"><a rel="nofollow" class="external text" href="https://chemdb.niaid.nih.gov/CompoundDetails.aspx?AIDSNO=471309">471309</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E8%9B%8B%E7%99%BD%E8%B3%AA%E8%B3%87%E6%96%99%E5%BA%AB" title="蛋白質資料庫">PDB配體ID</a></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li>RLT (<span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe-srv/PDBeXplore/ligand/?ligand=RLT">PDBe</a></span>, <span title="www.rcsb.org"><a rel="nofollow" class="external text" href="https://www.rcsb.org/ligand/RLT">RCSB PDB</a></span>)</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><span class="ilh-all" data-orig-title="CompTox化学品仪表板" data-lang-code="en" data-lang-name="英语" data-foreign-title="CompTox Chemicals Dashboard"><span class="ilh-page"><a href="/w/index.php?title=CompTox%E5%8C%96%E5%AD%A6%E5%93%81%E4%BB%AA%E8%A1%A8%E6%9D%BF&action=edit&redlink=1" class="new" title="CompTox化学品仪表板（页面不存在）">CompTox Dashboard</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/CompTox_Chemicals_Dashboard" class="extiw" title="en:CompTox Chemicals Dashboard"><span lang="en" dir="auto">CompTox Chemicals Dashboard</span></a></span>）</span></span> <span style="font-weight:normal">(<abbr title="美国国家环境保护局">EPA</abbr>)</span></th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID2048660">DTXSID2048660</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q421552#P3117" title="編輯維基數據鏈接"><img alt="編輯維基數據鏈接" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E6%AD%90%E6%B4%B2%E5%8C%96%E5%AD%B8%E5%93%81%E7%AE%A1%E7%90%86%E5%B1%80" title="歐洲化學品管理局"><span title="echa.europa.eu">ECHA InfoCard</span></a></th><td class="infobox-data" style=""><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.124.631">100.124.631</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q421552#P2566" title="編輯維基數據鏈接"><img alt="編輯維基數據鏈接" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;">化学信息</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E5%8C%96%E5%AD%A6%E5%BC%8F" title="化学式">化学式</a></th><td class="infobox-data" style=""><span title="Carbon">C</span><sub>20</sub><span title="Hydrogen">H</span><sub>21</sub><span title="Fluorine">F</span><span title="Nitrogen">N</span><sub>6</sub><span title="Oxygen">O</span><sub>5</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;"><a href="/wiki/%E6%91%A9%E5%B0%94%E8%B4%A8%E9%87%8F" title="摩尔质量">摩尔质量</a></th><td class="infobox-data" style="">444.42 g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;;">3D模型（<span class="ilh-all" data-orig-title="JSmol" data-lang-code="en" data-lang-name="英语" data-foreign-title="JSmol"><span class="ilh-page"><a href="/w/index.php?title=JSmol&action=edit&redlink=1" class="new" title="JSmol（页面不存在）">JSmol</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/JSmol" class="extiw" title="en:JSmol"><span lang="en" dir="auto">JSmol</span></a></span>）</span></span>）</th><td class="infobox-data" style=""><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r82655520"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=Cc1nnc%28o1%29C%28%3DO%29NC%28C%29%28C%29C%5C3%3DN%5CC%28C%28%3DO%29NCc2ccc%28F%29cc2%29%3DC%28%5CO%29C%28%3DO%29N%2F3C">交互式图像</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data" style=""><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/%E7%AE%80%E5%8C%96%E5%88%86%E5%AD%90%E7%BA%BF%E6%80%A7%E8%BE%93%E5%85%A5%E8%A7%84%E8%8C%83" title="简化分子线性输入规范">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Cc1nnc(o1)C(=O)NC(C)(C)C\3=N\C(C(=O)NCc2ccc(F)cc2)=C(\O)C(=O)N/3C</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data" style=""><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/%E5%9B%BD%E9%99%85%E5%8C%96%E5%90%88%E7%89%A9%E6%A0%87%E8%AF%86" title="国际化合物标识">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C20H21FN6O5/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30)<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:CZFFBEXEKNGXKS-UHFFFAOYSA-N<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li></ul> </div></td></tr></tbody></table> <p><b>拉替拉韦</b>（<i>Raltegravir</i>，缩写：<b>RAL</b>，商品名<b>艾生特</b>）是一种口服<a href="/wiki/%E6%8A%97%E5%8F%8D%E8%BD%89%E9%8C%84%E7%97%85%E6%AF%92%E8%97%A5%E7%89%A9" title="抗反轉錄病毒藥物">抗逆转录病毒药物</a>，临床应用其钾盐形式（<b>拉替拉韦钾</b>）用于治疗<a href="/wiki/%E8%89%BE%E6%BB%8B%E7%97%85" title="艾滋病">艾滋病</a> 。<sup id="cite_ref-BNF69_1-0" class="reference"><a href="#cite_note-BNF69-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>它还可以作为<a href="/wiki/%E6%9A%B4%E9%9C%B2%E5%90%8E%E9%A2%84%E9%98%B2%E7%96%97%E6%B3%95" title="暴露后预防疗法">暴露后预防疗法</a>用于预防艾滋病。<sup id="cite_ref-AHFS2017_2-0" class="reference"><a href="#cite_note-AHFS2017-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>该药是一种<a href="/wiki/%E6%95%B4%E5%90%88%E9%85%B6%E6%8A%91%E5%88%B6%E5%89%82" title="整合酶抑制剂">整合酶抑制剂</a>，可阻断病毒复制所需的HIV<a href="/wiki/%E6%95%B4%E5%90%88%E9%85%B6" title="整合酶">整合酶</a>的功能。 </p><p>拉替拉韦于2007年在美国被批准用于医疗用途，<sup id="cite_ref-AHFS2017_2-1" class="reference"><a href="#cite_note-AHFS2017-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>该药同时为<a href="/wiki/%E4%B8%96%E7%95%8C%E5%8D%AB%E7%94%9F%E7%BB%84%E7%BB%87%E5%9F%BA%E6%9C%AC%E8%8D%AF%E7%89%A9%E6%A0%87%E5%87%86%E6%B8%85%E5%8D%95" title="世界卫生组织基本药物标准清单">世界卫生组织基本药物</a>。<sup id="cite_ref-WHO21st_3-0" class="reference"><a href="#cite_note-WHO21st-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="临床应用"><span id=".E4.B8.B4.E5.BA.8A.E5.BA.94.E7.94.A8"></span>临床应用</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6&action=edit&section=1" title="编辑章节：临床应用"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:Isentress_pilules.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/72/Isentress_pilules.png/220px-Isentress_pilules.png" decoding="async" width="220" height="170" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/72/Isentress_pilules.png/330px-Isentress_pilules.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/72/Isentress_pilules.png/440px-Isentress_pilules.png 2x" data-file-width="524" data-file-height="406" /></a><figcaption> 拉替拉韦钾片剂</figcaption></figure> <p>拉替拉韦最初仅被批准用于对其他<a href="/wiki/%E6%8A%97%E5%8F%8D%E8%BD%89%E9%8C%84%E7%97%85%E6%AF%92%E8%97%A5%E7%89%A9" title="抗反轉錄病毒藥物">抗逆转录病毒药物</a>具有耐药性的患者。<sup id="cite_ref-fda_approval_package_4-0" class="reference"><a href="#cite_note-fda_approval_package-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>2009年7月，<a href="/wiki/%E7%BE%8E%E5%9B%BD%E9%A3%9F%E5%93%81%E8%8D%AF%E5%93%81%E7%9B%91%E7%9D%A3%E7%AE%A1%E7%90%86%E5%B1%80" title="美国食品药品监督管理局">FDA</a>批准该药作为一线药物治疗AIDS。<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>与其他HAART药物一样，由于HIV的高度致突变性，该药一般与其他作用机制的<a href="/wiki/%E6%8A%97%E5%8F%8D%E8%BD%89%E9%8C%84%E7%97%85%E6%AF%92%E8%97%A5%E7%89%A9" title="抗反轉錄病毒藥物">抗逆转录病毒药物</a>（如<a href="/wiki/%E6%8B%89%E7%B1%B3%E5%A4%AB%E5%AE%9A" title="拉米夫定">拉米夫定</a>）<a href="/wiki/%E9%B8%A1%E5%B0%BE%E9%85%92%E7%96%97%E6%B3%95" title="鸡尾酒疗法">联合使用</a>以降低HIV的耐药性。 </p><p>2011年12月，该药被批准用于2-11岁的儿童，11岁以上的青少年则按照成人剂量用药。<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="药效学"><span id=".E8.8D.AF.E6.95.88.E5.AD.A6"></span>药效学</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6&action=edit&section=2" title="编辑章节：药效学"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>在一项联合用药的研究中显示，拉替拉韦在24周和48周时表现出与<a href="/wiki/%E4%BE%9D%E6%B3%95%E9%9F%A6%E4%BB%91" title="依法韦仑">依法韦仑</a>相似的强效和持久的抗逆转录病毒活性，且能更快地降低血清中的HIV-1水平。在使用该药治疗的过程中，患者血清总<a href="/wiki/%E8%86%BD%E5%9B%BA%E9%86%87" title="膽固醇">胆固醇</a>、<a href="/wiki/%E4%BD%8E%E5%AF%86%E5%BA%A6%E8%84%82%E8%9B%8B%E7%99%BD" title="低密度脂蛋白">低密度脂蛋白</a>胆固醇和<a href="/wiki/%E4%B8%89%E9%85%B8%E7%94%98%E6%B2%B9%E9%85%AF" title="三酸甘油酯">甘油三酯</a>水平未有明显变化。<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="副作用"><span id=".E5.89.AF.E4.BD.9C.E7.94.A8"></span>副作用</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6&action=edit&section=3" title="编辑章节：副作用"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>该药常见的副作用包括失眠、疲倦、<a href="/wiki/%E6%81%B6%E5%BF%83" title="恶心">恶心</a>、<a href="/wiki/%E9%AB%98%E8%A1%80%E7%B3%96" title="高血糖">高血糖</a>和<a href="/wiki/%E9%A0%AD%E7%97%9B" title="頭痛">头痛</a>。<sup id="cite_ref-AHFS2017_2-2" class="reference"><a href="#cite_note-AHFS2017-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>严重的副作用可能包括<a href="/wiki/%E8%BF%87%E6%95%8F" title="过敏">过敏反应</a>（包括<a href="/wiki/%E5%8F%B2%E8%92%82%E8%8A%AC%E6%96%AF%EF%BC%8D%E5%BC%B7%E6%A3%AE%E7%97%87%E5%80%99%E7%BE%A4" class="mw-redirect" title="史蒂芬斯－強森症候群">史蒂文斯-约翰逊综合征</a>和<a href="/wiki/%E6%A8%AA%E7%BA%B9%E8%82%8C%E6%BA%B6%E8%A7%A3%E7%97%87" title="横纹肌溶解症">横纹肌溶解症</a>等）和<a href="/wiki/%E8%82%9D%E7%97%85" title="肝病">肝功能异常</a>。 </p><p>一项长达48周的试验显示，在接受过治疗的HIV-1患者中，该药和其他<a href="/wiki/%E6%8A%97%E5%8F%8D%E8%BD%89%E9%8C%84%E7%97%85%E6%AF%92%E8%97%A5%E7%89%A9" title="抗反轉錄病毒藥物">抗逆转录病毒药物</a>联合使用时耐受性良好。 <sup id="cite_ref-ralegravir_9-0" class="reference"><a href="#cite_note-ralegravir-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="作用机制"><span id=".E4.BD.9C.E7.94.A8.E6.9C.BA.E5.88.B6"></span>作用机制</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6&action=edit&section=4" title="编辑章节：作用机制"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>该药是一种<a href="/wiki/%E6%95%B4%E5%90%88%E9%85%B6%E6%8A%91%E5%88%B6%E5%89%82" title="整合酶抑制剂">整合酶抑制剂</a>，可阻断病毒复制所需的HIV<a href="/wiki/%E6%95%B4%E5%90%88%E9%85%B6" title="整合酶">整合酶</a>的功能。药物在体内通过葡萄糖醛酸化代谢掉。 <sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="历史"><span id=".E5.8E.86.E5.8F.B2"></span>历史</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6&action=edit&section=5" title="编辑章节：历史"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>2007年10月，拉替拉韦成为世界上第一种获批上市的整合酶抑制剂<sup id="cite_ref-fda_approval_package_4-1" class="reference"><a href="#cite_note-fda_approval_package-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup>。该药由<a href="/wiki/%E9%BB%98%E5%85%8B%E8%97%A5%E5%BB%A0" title="默克藥廠">默沙东</a>开发。<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="研究"><span id=".E7.A0.94.E7.A9.B6"></span>研究</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6&action=edit&section=6" title="编辑章节：研究"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>研究表明，拉替拉韦显着改变了HIV的病毒动力学。在临床试验中，服用拉替拉韦钾的患者比服用非核苷类<a href="/wiki/%E9%80%86%E8%BD%AC%E5%BD%95%E9%85%B6%E6%8A%91%E5%88%B6%E5%89%82" title="逆转录酶抑制剂">逆转录酶抑制剂</a>或蛋白酶抑制剂的患者能更快地达到低于每毫升50个拷贝的病毒载量。这种病毒载量减少的统计学显着差异导致一些HIV研究人员开始质疑长期以来关于HIV病毒动力学和衰减的范式。<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p><p>对<a href="/wiki/%E4%BA%BA%E5%B7%A8%E7%BB%86%E8%83%9E%E7%97%85%E6%AF%92" title="人巨细胞病毒">人巨细胞病毒</a>终止酶蛋白的研究表明，拉替拉韦可能会阻止<a href="/wiki/%E7%96%B1%E7%96%B9%E7%97%85%E6%AF%92%E7%A7%91" title="疱疹病毒科">疱疹</a>病毒的复制。<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p><p>2013年1月，默沙东启动了一项II期试验，以评估拉替拉韦在治疗<a href="/wiki/%E5%A4%9A%E5%8F%91%E6%80%A7%E7%A1%AC%E5%8C%96%E7%97%87" title="多发性硬化症">多发性硬化症</a>（MS）中的疗效。<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup>该药物对人<a href="/wiki/%E5%85%A7%E6%BA%90%E6%80%A7%E5%8F%8D%E8%BD%89%E9%8C%84%E7%97%85%E6%AF%92" title="內源性反轉錄病毒">内源性逆转录病毒</a>（HERV）和<a href="/wiki/%E4%BA%BA%E9%A1%9E%E7%96%B1%E7%96%B9%E7%97%85%E6%AF%92%E7%AC%AC%E5%9B%9B%E5%9E%8B" title="人類疱疹病毒第四型">EB病毒</a>具有活性，这已在复发缓解型MS的发病机制中得到证实。 </p> <div class="mw-heading mw-heading2"><h2 id="参考文献"><span id=".E5.8F.82.E8.80.83.E6.96.87.E7.8C.AE"></span>参考文献</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6&action=edit&section=7" title="编辑章节：参考文献"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="reflist columns references-column-count references-column-count-2" style="-moz-column-count: 2; -webkit-column-count: 2; column-count: 2; list-style-type: decimal;"> <ol class="references"> <li id="cite_note-BNF69-1"><span class="mw-cite-backlink"><b><a 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March 6, 2008, <b>51</b> (18): 5843–5855. <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/18763751"><span title="公共医学识别码">PMID 18763751</span></a>. <a rel="nofollow" class="external text" href="https://doi.org/10.1021%2Fjm800245z"><span title="數位物件識別號">doi:10.1021/jm800245z</span></a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6&rft.atitle=Discovery+of+Raltegravir%2C+a+Potent%2C+Selective+Orally+Bioavailable+HIV-Integrase+Inhibitor+for+the+Treatment+of+HIV-AIDS+Infection&rft.date=2008-03-06&rft.genre=article&rft.issue=18&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.pages=5843-5855&rft.volume=51&rft_id=info%3Adoi%2F10.1021%2Fjm800245z&rft_id=info%3Apmid%2F18763751&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-13">^</a></b></span> <span class="reference-text"><cite class="citation web"><a rel="nofollow" class="external text" href="https://www.thebodypro.com/article/faster-viral-decay-raltegravir">Faster Viral Decay With Raltegravir</a>. www.thebodypro.com. <span class="reference-accessdate"> [<span class="nowrap">2021-07-01</span>]</span>. （原始内容<a rel="nofollow" class="external text" href="https://web.archive.org/web/20200806165044/https://www.thebodypro.com/article/faster-viral-decay-raltegravir">存档</a>于2020-08-06）.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6&rft.atitle=Faster+Viral+Decay+With+Raltegravir&rft.genre=unknown&rft.jtitle=www.thebodypro.com&rft_id=https%3A%2F%2Fwww.thebodypro.com%2Farticle%2Ffaster-viral-decay-raltegravir&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-14">^</a></b></span> <span class="reference-text">Clinical trial number <i><a rel="nofollow" class="external text" href="https://www.clinicaltrials.gov/ct2/show/NCT00554398">NCT00554398</a></i> for "Impact of MK-0518 (Raltegravir) Intensification on HIV-1 Viral Latency in Patients With Previous Complete Viral Suppression" at ClinicalTrials.gov </span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-15">^</a></b></span> <span class="reference-text"><cite class="citation web"><a rel="nofollow" class="external text" href="https://www.sciencedaily.com/releases/2010/09/100923081859.htm">Drug against AIDS could be effective against herpesvirus</a>. ScienceDaily. <span class="reference-accessdate"> [<span class="nowrap">2021-07-01</span>]</span>. （原始内容<a rel="nofollow" class="external text" href="https://web.archive.org/web/20160305200817/https://www.sciencedaily.com/releases/2010/09/100923081859.htm">存档</a>于2016-03-05）.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6&rft.atitle=Drug+against+AIDS+could+be+effective+against+herpesvirus&rft.genre=unknown&rft.jtitle=ScienceDaily&rft_id=https%3A%2F%2Fwww.sciencedaily.com%2Freleases%2F2010%2F09%2F100923081859.htm&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-16">^</a></b></span> <span class="reference-text"><cite class="citation web"><a rel="nofollow" class="external text" href="https://clinicaltrials.gov/ct2/show/NCT01767701">Raltegravir (Isentress) Pilot Study in Relapsing Multiple Sclerosis - Full Text View - ClinicalTrials.gov</a>. clinicaltrials.gov. <span class="reference-accessdate"> [<span class="nowrap">2021-07-01</span>]</span>. （原始内容<a rel="nofollow" class="external text" href="https://web.archive.org/web/20200806171334/https://clinicaltrials.gov/ct2/show/NCT01767701">存档</a>于2020-08-06）.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6&rft.atitle=Raltegravir+%28Isentress%29+Pilot+Study+in+Relapsing+Multiple+Sclerosis+-+Full+Text+View+-+ClinicalTrials.gov&rft.genre=unknown&rft.jtitle=clinicaltrials.gov&rft_id=https%3A%2F%2Fclinicaltrials.gov%2Fct2%2Fshow%2FNCT01767701&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="外部链接"><span id=".E5.A4.96.E9.83.A8.E9.93.BE.E6.8E.A5"></span>外部链接</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6&action=edit&section=8" title="编辑章节：外部链接"><span>编辑</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><cite class="citation web"><a rel="nofollow" class="external text" href="https://druginfo.nlm.nih.gov/drugportal/name/raltegravir">Raltegravir</a>. Drug Information Portal. U.S. National Library of Medicine. <span class="reference-accessdate"> [<span class="nowrap">2021-07-01</span>]</span>. （原始内容<a rel="nofollow" class="external text" href="https://web.archive.org/web/20210716155740/https://druginfo.nlm.nih.gov/drugportal/name/raltegravir">存档</a>于2021-07-16）.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E6%8B%89%E6%9B%BF%E6%8B%89%E9%9F%A6&rft.atitle=Raltegravir&rft.genre=unknown&rft.jtitle=Drug+Information+Portal&rft_id=https%3A%2F%2Fdruginfo.nlm.nih.gov%2Fdrugportal%2Fname%2Fraltegravir&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></li> <li><cite class="citation web"><a rel="nofollow" class="external text" href="https://druginfo.nlm.nih.gov/drugportal/name/raltegravir%20potassium">Raltegravir potassium</a>. Drug Information Portal. 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style="width:1%">公司董事</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><span class="ilh-all" data-orig-title="Richard Clark (Pharmacologist)" data-lang-code="en" data-lang-name="英语" data-foreign-title="Richard Clark (Pharmacologist)"><span class="ilh-page"><a href="/w/index.php?title=Richard_Clark_(Pharmacologist)&action=edit&redlink=1" class="new" title="Richard Clark (Pharmacologist)（页面不存在）">Richard Clark</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Richard_Clark_(Pharmacologist)" class="extiw" title="en:Richard Clark (Pharmacologist)"><span lang="en" dir="auto">Richard Clark (Pharmacologist)</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="Johnnetta Cole" data-lang-code="en" data-lang-name="英语" data-foreign-title="Johnnetta Cole"><span class="ilh-page"><a href="/w/index.php?title=Johnnetta_Cole&action=edit&redlink=1" class="new" title="Johnnetta Cole（页面不存在）">Johnnetta Cole</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Johnnetta_Cole" class="extiw" title="en:Johnnetta Cole"><span lang="en" dir="auto">Johnnetta Cole</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="William B. Harrison, Jr." data-lang-code="en" data-lang-name="英语" data-foreign-title="William B. Harrison, Jr."><span class="ilh-page"><a href="/w/index.php?title=William_B._Harrison,_Jr.&action=edit&redlink=1" class="new" title="William B. Harrison, Jr.（页面不存在）">William Harrison</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/William_B._Harrison,_Jr." class="extiw" title="en:William B. Harrison, Jr."><span lang="en" dir="auto">William B. Harrison, Jr.</span></a></span>）</span></span></li> <li><a href="/w/index.php?title=William_N._Kelley&action=edit&redlink=1" class="new" title="William N. Kelley（页面不存在）">William Kelley</a></li> <li><span class="ilh-all" data-orig-title="Rochelle Lazarus" data-lang-code="en" data-lang-name="英语" data-foreign-title="Rochelle Lazarus"><span class="ilh-page"><a href="/w/index.php?title=Rochelle_Lazarus&action=edit&redlink=1" class="new" title="Rochelle Lazarus（页面不存在）">Rochelle Lazarus</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Rochelle_Lazarus" class="extiw" title="en:Rochelle Lazarus"><span lang="en" dir="auto">Rochelle Lazarus</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="Thomas Shenk" data-lang-code="en" data-lang-name="英语" data-foreign-title="Thomas Shenk"><span class="ilh-page"><a href="/w/index.php?title=Thomas_Shenk&action=edit&redlink=1" class="new" title="Thomas Shenk（页面不存在）">Thomas Shenk</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Thomas_Shenk" class="extiw" title="en:Thomas Shenk"><span lang="en" dir="auto">Thomas Shenk</span></a></span>）</span></span></li> <li><a href="/w/index.php?title=Anne_Tatlock&action=edit&redlink=1" class="new" title="Anne Tatlock（页面不存在）">Anne Tatlock</a></li> <li><a href="/w/index.php?title=Samuel_Thier&action=edit&redlink=1" class="new" title="Samuel Thier（页面不存在）">Samuel Thier</a></li> <li><a href="/w/index.php?title=Wendell_Weeks&action=edit&redlink=1" class="new" title="Wendell Weeks（页面不存在）">Wendell Weeks</a></li> <li><a href="/w/index.php?title=Peter_Wendell&action=edit&redlink=1" class="new" title="Peter Wendell（页面不存在）">Peter Wendell</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">产品</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><span class="ilh-all" data-orig-title="阿仑膦酸" data-lang-code="en" data-lang-name="英语" data-foreign-title="Alendronic acid"><span class="ilh-page"><a href="/w/index.php?title=%E9%98%BF%E4%BB%91%E8%86%A6%E9%85%B8&action=edit&redlink=1" class="new" title="阿仑膦酸（页面不存在）">阿仑膦酸</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Alendronic_acid" class="extiw" title="en:Alendronic acid"><span lang="en" dir="auto">Alendronic acid</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="阿瑞吡坦" data-lang-code="en" data-lang-name="英语" data-foreign-title="Aprepitant"><span class="ilh-page"><a href="/w/index.php?title=%E9%98%BF%E7%91%9E%E5%90%A1%E5%9D%A6&action=edit&redlink=1" class="new" title="阿瑞吡坦（页面不存在）">阿瑞吡坦</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Aprepitant" class="extiw" title="en:Aprepitant"><span lang="en" dir="auto">Aprepitant</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="艾尔巴韦/格拉瑞韦" data-lang-code="en" data-lang-name="英语" data-foreign-title="Elbasvir/grazoprevir"><span class="ilh-page"><a href="/w/index.php?title=%E8%89%BE%E5%B0%94%E5%B7%B4%E9%9F%A6/%E6%A0%BC%E6%8B%89%E7%91%9E%E9%9F%A6&action=edit&redlink=1" class="new" title="艾尔巴韦/格拉瑞韦（页面不存在）">艾尔巴韦/格拉瑞韦</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Elbasvir/grazoprevir" class="extiw" title="en:Elbasvir/grazoprevir"><span lang="en" dir="auto">Elbasvir/grazoprevir</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="艾托格列净" data-lang-code="en" data-lang-name="英语" data-foreign-title="Ertugliflozin"><span class="ilh-page"><a href="/w/index.php?title=%E8%89%BE%E6%89%98%E6%A0%BC%E5%88%97%E5%87%80&action=edit&redlink=1" class="new" title="艾托格列净（页面不存在）">艾托格列净</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Ertugliflozin" class="extiw" title="en:Ertugliflozin"><span lang="en" dir="auto">Ertugliflozin</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="泊沙康唑" data-lang-code="en" data-lang-name="英语" data-foreign-title="Posaconazole"><span class="ilh-page"><a href="/w/index.php?title=%E6%B3%8A%E6%B2%99%E5%BA%B7%E5%94%91&action=edit&redlink=1" class="new" title="泊沙康唑（页面不存在）">泊沙康唑</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Posaconazole" class="extiw" title="en:Posaconazole"><span lang="en" dir="auto">Posaconazole</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="多拉韦林" data-lang-code="en" data-lang-name="英语" data-foreign-title="Doravirine"><span class="ilh-page"><a href="/w/index.php?title=%E5%A4%9A%E6%8B%89%E9%9F%A6%E6%9E%97&action=edit&redlink=1" class="new" title="多拉韦林（页面不存在）">多拉韦林</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Doravirine" class="extiw" title="en:Doravirine"><span lang="en" dir="auto">Doravirine</span></a></span>）</span></span></li> <li><a href="/wiki/%E5%8E%84%E4%BB%96%E5%9F%B9%E5%8D%97" title="厄他培南">厄他培南</a></li> <li><a href="/wiki/%E9%9D%9E%E9%82%A3%E9%9B%84%E8%83%BA" title="非那雄胺">非那斯特莱</a></li> <li><a href="/wiki/%E4%BC%8F%E7%AB%8B%E8%AF%BA%E4%BB%96" title="伏立诺他">伏立诺他</a></li> <li><a href="/wiki/%E7%A6%8F%E6%B2%99%E5%8C%B9%E5%9D%A6" title="福沙匹坦">福沙匹坦</a></li> <li><a href="/wiki/%E5%8D%A1%E6%B3%8A%E8%8A%AC%E6%B7%A8" title="卡泊芬淨">卡泊芬净</a></li> <li><a href="/wiki/%E6%B0%AF%E6%B2%99%E5%9D%A6" title="氯沙坦">氯沙坦</a></li> <li><span class="ilh-all" data-orig-title="洛伐他汀" data-lang-code="en" data-lang-name="英语" data-foreign-title="lovastatin"><span class="ilh-page"><a href="/w/index.php?title=%E6%B4%9B%E4%BC%90%E4%BB%96%E6%B1%80&action=edit&redlink=1" class="new" title="洛伐他汀（页面不存在）">洛伐他汀</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/lovastatin" class="extiw" title="en:lovastatin"><span lang="en" dir="auto">lovastatin</span></a></span>）</span></span></li> <li><a class="mw-selflink selflink">拉替拉韦</a></li> <li><span class="ilh-all" data-orig-title="来特莫韦" data-lang-code="en" data-lang-name="英语" data-foreign-title="letermovir"><span class="ilh-page"><a href="/w/index.php?title=%E6%9D%A5%E7%89%B9%E8%8E%AB%E9%9F%A6&action=edit&redlink=1" class="new" title="来特莫韦（页面不存在）">来特莫韦</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/letermovir" class="extiw" title="en:letermovir"><span lang="en" dir="auto">letermovir</span></a></span>）</span></span></li> <li><a href="/wiki/%E5%88%A9%E6%89%8E%E6%9B%B2%E5%9D%A6" title="利扎曲坦">利扎曲坦</a></li> <li><a href="/wiki/%E7%BD%97%E9%9D%9E%E6%98%94%E5%B8%83" title="罗非昔布">罗非昔布</a></li> <li><span class="ilh-all" data-orig-title="罗库溴铵" data-lang-code="en" data-lang-name="英语" data-foreign-title="Rocuronium bromide"><span class="ilh-page"><a href="/w/index.php?title=%E7%BD%97%E5%BA%93%E6%BA%B4%E9%93%B5&action=edit&redlink=1" class="new" title="罗库溴铵（页面不存在）">罗库溴铵</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Rocuronium_bromide" class="extiw" title="en:Rocuronium bromide"><span lang="en" dir="auto">Rocuronium bromide</span></a></span>）</span></span></li> <li><a href="/wiki/%E8%8E%AB%E5%8A%AA%E5%8C%B9%E9%9F%8B" title="莫努匹韋">莫诺拉韦</a></li> <li><a href="/wiki/%E5%AD%9F%E9%B2%81%E5%8F%B8%E7%89%B9" title="孟鲁司特">孟鲁司特</a></li> <li><a href="/wiki/%E5%A5%A5%E6%A0%BC%E5%88%97%E6%B1%80" title="奥格列汀">奥格列汀</a></li> <li><a href="/wiki/%E5%B8%95%E5%8D%9A%E5%88%A9%E7%8F%A0%E5%8D%95%E6%8A%97" title="帕博利珠单抗">帕博利珠单抗</a></li> <li><a href="/w/index.php?title=%E5%8D%81%E4%B8%80%E9%85%B8%E7%9D%BE%E9%85%AE&action=edit&redlink=1" class="new" title="十一酸睾酮（页面不存在）">十一酸睾酮</a></li> <li><span class="ilh-all" data-orig-title="舒更葡糖钠" data-lang-code="en" data-lang-name="英语" data-foreign-title="Sugammadex"><span class="ilh-page"><a href="/w/index.php?title=%E8%88%92%E6%9B%B4%E8%91%A1%E7%B3%96%E9%92%A0&action=edit&redlink=1" class="new" title="舒更葡糖钠（页面不存在）">舒更葡糖钠</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Sugammadex" class="extiw" title="en:Sugammadex"><span lang="en" dir="auto">Sugammadex</span></a></span>）</span></span></li> <li><a href="/wiki/%E6%9B%BF%E8%8E%AB%E5%94%91%E8%83%BA" title="替莫唑胺">替莫唑胺</a></li> <li><a href="/wiki/%E8%BE%9B%E4%BC%90%E4%BB%96%E6%B1%80" title="辛伐他汀">辛伐他汀</a></li> <li><a href="/wiki/%E8%A5%BF%E6%A0%BC%E5%88%97%E6%B1%80" title="西格列汀">西格列汀</a></li> <li><a href="/wiki/%E4%BA%9A%E8%83%BA%E5%9F%B9%E5%8D%97/%E8%A5%BF%E5%8F%B8%E4%BB%96%E4%B8%81" title="亚胺培南/西司他丁">亚胺培南/西司他丁</a></li> <li><a href="/wiki/%E4%BE%9D%E6%8A%98%E9%BA%A6%E5%B8%83" title="依折麦布">依折麦布</a></li> <li><span class="ilh-all" data-orig-title="依折麦布/辛伐他汀" data-lang-code="en" data-lang-name="英语" data-foreign-title="Ezetimibe/simvastatin"><span class="ilh-page"><a href="/w/index.php?title=%E4%BE%9D%E6%8A%98%E9%BA%A6%E5%B8%83/%E8%BE%9B%E4%BC%90%E4%BB%96%E6%B1%80&action=edit&redlink=1" class="new" title="依折麦布/辛伐他汀（页面不存在）">依折麦布/辛伐他汀</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Ezetimibe/simvastatin" class="extiw" title="en:Ezetimibe/simvastatin"><span lang="en" dir="auto">Ezetimibe/simvastatin</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="茚地那韦" data-lang-code="en" data-lang-name="英语" data-foreign-title="Indinavir"><span class="ilh-page"><a href="/w/index.php?title=%E8%8C%9A%E5%9C%B0%E9%82%A3%E9%9F%A6&action=edit&redlink=1" class="new" title="茚地那韦（页面不存在）">茚地那韦</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Indinavir" class="extiw" title="en:Indinavir"><span lang="en" dir="auto">Indinavir</span></a></span>）</span></span></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">出版物</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E9%BB%98%E5%85%8B%E6%89%8B%E5%86%8C" title="默克手册">默克手册</a> <ul><li><a href="/wiki/%E9%BB%98%E5%85%8B%E7%B4%A2%E5%BC%95" title="默克索引">默克索引</a></li> <li><a href="/wiki/%E9%BB%98%E6%B2%99%E6%9D%B1%E8%A8%BA%E7%99%82%E6%89%8B%E5%86%8A" title="默沙東診療手冊">默克诊疗手册</a></li> <li><span class="ilh-all" data-orig-title="默克兽医手册" data-lang-code="en" data-lang-name="英语" data-foreign-title="Merck Veterinary Manual"><span class="ilh-page"><a href="/w/index.php?title=%E9%BB%98%E5%85%8B%E5%85%BD%E5%8C%BB%E6%89%8B%E5%86%8C&action=edit&redlink=1" class="new" title="默克兽医手册（页面不存在）">默克兽医手册</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Merck_Veterinary_Manual" class="extiw" title="en:Merck Veterinary Manual"><span lang="en" dir="auto">Merck Veterinary Manual</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="默克老年病手册" data-lang-code="en" data-lang-name="英语" data-foreign-title="Merck Manual of Geriatrics"><span class="ilh-page"><a href="/w/index.php?title=%E9%BB%98%E5%85%8B%E8%80%81%E5%B9%B4%E7%97%85%E6%89%8B%E5%86%8C&action=edit&redlink=1" class="new" title="默克老年病手册（页面不存在）">默克老年病手册</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Merck_Manual_of_Geriatrics" class="extiw" title="en:Merck Manual of Geriatrics"><span lang="en" dir="auto">Merck Manual of Geriatrics</span></a></span>）</span></span></li></ul></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div>其他相关公司：<a href="/wiki/%E9%BB%98%E5%85%8B%E9%9B%86%E5%9C%98" title="默克集團">默克集團</a>（从同一家德国公司分拆的两个独立公司） · <span class="nowrap"><a href="/wiki/%E5%85%88%E7%81%B5%E8%91%86%E9%9B%85" title="先灵葆雅">先灵葆雅</a>（2009年被收购成为子公司）</span></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84265675"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84261037"></div><div role="navigation" class="navbox" aria-labelledby="抗病毒药物：用于防治HIV的抗逆转录病毒药物（主要J05）" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="collapsible-title navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84265675"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r84244141"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:%E6%8A%97%E9%80%86%E8%BD%AC%E5%BD%95%E7%97%85%E6%AF%92%E8%8D%AF%E7%89%A9" title="Template:抗逆转录病毒药物"><abbr title="查看该模板">查</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:%E6%8A%97%E9%80%86%E8%BD%AC%E5%BD%95%E7%97%85%E6%AF%92%E8%8D%AF%E7%89%A9" title="Template talk:抗逆转录病毒药物"><abbr title="讨论该模板">论</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:%E7%BC%96%E8%BE%91%E9%A1%B5%E9%9D%A2/Template:%E6%8A%97%E9%80%86%E8%BD%AC%E5%BD%95%E7%97%85%E6%AF%92%E8%8D%AF%E7%89%A9" title="Special:编辑页面/Template:抗逆转录病毒药物"><abbr title="编辑该模板">编</abbr></a></li></ul></div><div id="抗病毒药物：用于防治HIV的抗逆转录病毒药物（主要J05）" style="font-size:110%;margin:0 5em"><a href="/wiki/%E6%8A%97%E7%97%85%E6%AF%92%E8%8D%AF%E7%89%A9" title="抗病毒药物">抗病毒药物</a>：用于防治<a href="/wiki/%E4%BA%BA%E9%A1%9E%E5%85%8D%E7%96%AB%E7%BC%BA%E9%99%B7%E7%97%85%E6%AF%92" title="人類免疫缺陷病毒">HIV</a>的<a href="/wiki/%E6%8A%97%E5%8F%8D%E8%BD%89%E9%8C%84%E7%97%85%E6%AF%92%E8%97%A5%E7%89%A9" title="抗反轉錄病毒藥物">抗逆转录病毒药物</a>（主要<a href="/wiki/ATC%E4%BB%A3%E7%A0%81_(J05)" title="ATC代码 (J05)">J05</a>）</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;"><center><a href="/wiki/%E8%9E%8D%E5%90%88%E6%8A%91%E5%88%B6%E5%89%82" title="融合抑制剂">融合抑制剂</a></center>（进入抑制剂）</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><i><a href="/w/index.php?title=Gp41&action=edit&redlink=1" class="new" title="Gp41（页面不存在）">gp41</a></i> <ul><li><a href="/wiki/%E6%81%A9%E5%A4%AB%E9%9F%A6%E5%9C%B0" title="恩夫韦地">恩夫韦地</a></li></ul></li> <li><i><a href="/wiki/CCR5" title="CCR5">CCR5</a></i> <ul><li><a href="/wiki/%E9%A9%AC%E6%8B%89%E9%9F%A6%E7%BD%97" title="马拉韦罗">马拉维诺</a></li> <li>Vicriviroc<sup>†</sup></li> <li><a href="/w/index.php?title=PRO_140&action=edit&redlink=1" class="new" title="PRO 140（页面不存在）">PRO 140</a><sup>†</sup></li></ul></li> <li><i><a href="/wiki/CD4" class="mw-redirect" title="CD4">CD4</a></i> <ul><li><a href="/wiki/%E4%BC%8A%E5%B7%B4%E7%8F%A0%E5%8D%95%E6%8A%97" title="伊巴珠单抗">伊巴珠单抗</a><sup>†</sup></li></ul></li> <li><i><a href="/w/index.php?title=Gp120&action=edit&redlink=1" class="new" title="Gp120（页面不存在）">gp120</a></i> <ul><li><a href="/wiki/%E7%A6%8F%E6%9B%BF%E6%B2%99%E9%9F%A6" title="福替沙韦">福替沙韦‎</a><sup>§</sup></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;"><a href="/wiki/%E9%80%86%E8%BD%AC%E5%BD%95%E9%85%B6%E6%8A%91%E5%88%B6%E5%89%82" title="逆转录酶抑制剂">逆转录酶抑制剂</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;"><span class="ilh-all" data-orig-title="核苷类似物" data-lang-code="en" data-lang-name="英语" data-foreign-title="Nucleoside analogue"><span class="ilh-page"><a href="/w/index.php?title=%E6%A0%B8%E8%8B%B7%E7%B1%BB%E4%BC%BC%E7%89%A9&action=edit&redlink=1" class="new" title="核苷类似物（页面不存在）">核苷类似物</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Nucleoside_analogue" class="extiw" title="en:Nucleoside analogue"><span lang="en" dir="auto">Nucleoside analogue</span></a></span>）</span></span>（NRTI）</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E9%98%BF%E5%B7%B4%E5%8D%A1%E7%B6%AD" title="阿巴卡維">阿巴卡韦</a>°<sup>§</sup></li> <li><a href="/wiki/%E5%9C%B0%E8%BE%BE%E8%AF%BA%E6%96%B0" title="地达诺新">去羟肌苷</a><sup>§</sup></li> <li><a href="/wiki/%E6%81%A9%E6%9B%B2%E4%BB%96%E6%BB%A8" title="恩曲他滨">恩曲他滨</a>°<sup>§</sup></li> <li><a href="/wiki/%E6%8B%89%E7%B1%B3%E5%A4%AB%E5%AE%9A" title="拉米夫定">拉米夫定</a>°<sup>§</sup></li> <li><a href="/wiki/%E5%8F%B8%E4%BB%96%E5%A4%AB%E5%AE%9A" title="司他夫定">司他夫定</a><sup>§</sup></li> <li><a href="/wiki/%E9%BD%90%E5%A4%9A%E5%A4%AB%E5%AE%9A" title="齐多夫定">齐多夫定</a><sup>§</sup></li> <li><span class="ilh-all" data-orig-title="氨多索韦" data-lang-code="en" data-lang-name="英语" data-foreign-title="Amdoxovir"><span class="ilh-page"><a href="/w/index.php?title=%E6%B0%A8%E5%A4%9A%E7%B4%A2%E9%9F%A6&action=edit&redlink=1" class="new" title="氨多索韦（页面不存在）">氨多索韦</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Amdoxovir" class="extiw" title="en:Amdoxovir"><span lang="en" dir="auto">Amdoxovir</span></a></span>）</span></span><sup>†</sup></li> <li><span class="ilh-all" data-orig-title="阿立他滨" data-lang-code="en" data-lang-name="英语" data-foreign-title="Apricitabine"><span class="ilh-page"><a href="/w/index.php?title=%E9%98%BF%E7%AB%8B%E4%BB%96%E6%BB%A8&action=edit&redlink=1" class="new" title="阿立他滨（页面不存在）">阿立他滨</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Apricitabine" class="extiw" title="en:Apricitabine"><span lang="en" dir="auto">Apricitabine</span></a></span>）</span></span><sup>†</sup></li> <li><a href="/wiki/%E6%A3%AE%E6%B2%99%E5%A4%AB%E5%AE%9A" title="森沙夫定">森沙夫定</a></li> <li><span class="ilh-all" data-orig-title="艾夫他滨" data-lang-code="en" data-lang-name="英语" data-foreign-title="Elvucitabine"><span class="ilh-page"><a href="/w/index.php?title=%E8%89%BE%E5%A4%AB%E4%BB%96%E6%BB%A8&action=edit&redlink=1" class="new" title="艾夫他滨（页面不存在）">艾夫他滨</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Elvucitabine" class="extiw" title="en:Elvucitabine"><span lang="en" dir="auto">Elvucitabine</span></a></span>）</span></span><sup>†</sup></li> <li>Islatravir</li> <li><span class="ilh-all" data-orig-title="拉西韦" data-lang-code="en" data-lang-name="英语" data-foreign-title="Racivir"><span class="ilh-page"><a href="/w/index.php?title=%E6%8B%89%E8%A5%BF%E9%9F%A6&action=edit&redlink=1" class="new" title="拉西韦（页面不存在）">拉西韦</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Racivir" class="extiw" title="en:Racivir"><span lang="en" dir="auto">Racivir</span></a></span>）</span></span><sup>†</sup></li> <li><span class="ilh-all" data-orig-title="斯坦匹定" data-lang-code="en" data-lang-name="英语" data-foreign-title="Stampidine"><span class="ilh-page"><a href="/w/index.php?title=%E6%96%AF%E5%9D%A6%E5%8C%B9%E5%AE%9A&action=edit&redlink=1" class="new" title="斯坦匹定（页面不存在）">斯坦匹定</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Stampidine" class="extiw" title="en:Stampidine"><span lang="en" dir="auto">Stampidine</span></a></span>）</span></span><sup>†</sup></li> <li><span class="ilh-all" data-orig-title="扎西他滨" data-lang-code="en" data-lang-name="英语" data-foreign-title="Zalcitabine"><span class="ilh-page"><a href="/w/index.php?title=%E6%89%8E%E8%A5%BF%E4%BB%96%E6%BB%A8&action=edit&redlink=1" class="new" title="扎西他滨（页面不存在）">扎西他滨</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Zalcitabine" class="extiw" title="en:Zalcitabine"><span lang="en" dir="auto">Zalcitabine</span></a></span>）</span></span><sup>‡</sup></li> <li><a href="/wiki/%E6%9B%BF%E8%AF%BA%E7%A6%8F%E9%9F%A6%E4%BA%8C%E5%90%A1%E5%91%8B%E9%85%AF" title="替诺福韦二吡呋酯">替诺福韦</a>°<sup>§</sup>（<a href="/wiki/%E4%B8%99%E9%85%9A%E6%9B%BF%E8%AF%BA%E7%A6%8F%E9%9F%A6" title="丙酚替诺福韦">丙酚替诺福韦</a>）</li> <li><a href="/wiki/%E9%98%BF%E5%85%B9%E5%A4%AB%E5%AE%9A" title="阿兹夫定">阿兹夫定</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;"><span class="ilh-all" data-orig-title="非核苷类逆转录酶抑制剂的发现与发展" data-lang-code="en" data-lang-name="英语" data-foreign-title="Discovery and development of non-nucleoside reverse-transcriptase inhibitors"><span class="ilh-page"><a href="/w/index.php?title=%E9%9D%9E%E6%A0%B8%E8%8B%B7%E7%B1%BB%E9%80%86%E8%BD%AC%E5%BD%95%E9%85%B6%E6%8A%91%E5%88%B6%E5%89%82%E7%9A%84%E5%8F%91%E7%8E%B0%E4%B8%8E%E5%8F%91%E5%B1%95&action=edit&redlink=1" class="new" title="非核苷类逆转录酶抑制剂的发现与发展（页面不存在）">非核苷类似物</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Discovery_and_development_of_non-nucleoside_reverse-transcriptase_inhibitors" class="extiw" title="en:Discovery and development of non-nucleoside reverse-transcriptase inhibitors"><span lang="en" dir="auto">Discovery and development of non-nucleoside reverse-transcriptase inhibitors</span></a></span>）</span></span>（NNRTI）</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px"><div style="padding:0em 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;">第一代</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E4%BE%9D%E6%B3%95%E9%9F%A6%E4%BB%91" title="依法韦仑">依法韦仑</a>°<sup>§</sup></li> <li><a href="/wiki/%E5%A5%88%E9%9F%8B%E6%8B%89%E5%B9%B3" title="奈韋拉平">奈韋拉平</a><sup>§</sup></li> <li><span class="ilh-all" data-orig-title="地拉韦啶" data-lang-code="en" data-lang-name="英语" data-foreign-title="Delavirdine"><span class="ilh-page"><a href="/w/index.php?title=%E5%9C%B0%E6%8B%89%E9%9F%A6%E5%95%B6&action=edit&redlink=1" class="new" title="地拉韦啶（页面不存在）">地拉韦啶</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Delavirdine" class="extiw" title="en:Delavirdine"><span lang="en" dir="auto">Delavirdine</span></a></span>）</span></span><sup>‡</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;">第二代</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li>二芳基嘧啶 <ul><li><a href="/wiki/%E4%BE%9D%E6%9B%B2%E9%9F%A6%E6%9E%97" title="依曲韦林">依曲韦林</a></li> <li><span class="ilh-all" data-orig-title="利匹韦林" data-lang-code="en" data-lang-name="英语" data-foreign-title="Rilpivirine"><span class="ilh-page"><a href="/w/index.php?title=%E5%88%A9%E5%8C%B9%E9%9F%A6%E6%9E%97&action=edit&redlink=1" class="new" title="利匹韦林（页面不存在）">利匹韦林</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Rilpivirine" class="extiw" title="en:Rilpivirine"><span lang="en" dir="auto">Rilpivirine</span></a></span>）</span></span><sup>†</sup></li></ul></li> <li><span class="ilh-all" data-orig-title="多拉韦林" data-lang-code="en" data-lang-name="英语" data-foreign-title="Doravirine"><span class="ilh-page"><a href="/w/index.php?title=%E5%A4%9A%E6%8B%89%E9%9F%A6%E6%9E%97&action=edit&redlink=1" class="new" title="多拉韦林（页面不存在）">多拉韦林</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Doravirine" class="extiw" title="en:Doravirine"><span lang="en" dir="auto">Doravirine</span></a></span>）</span></span></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;"><a href="/wiki/%E6%95%B4%E5%90%88%E9%85%B6%E6%8A%91%E5%88%B6%E5%89%82" title="整合酶抑制剂">整合酶抑制剂</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E5%A4%9A%E6%9B%BF%E6%8B%89%E9%9F%A6" title="多替拉韦">多替拉韦</a></li> <li><a href="/wiki/%E5%9F%83%E6%9B%BF%E6%8B%89%E9%9F%A6" title="埃替拉韦">埃替拉韦</a><sup>†</sup></li> <li><a class="mw-selflink selflink">拉替拉韦</a></li> <li>Globoidnan A (experimental)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;"><a href="/w/index.php?title=%E6%88%90%E7%86%9F%E6%8A%91%E5%88%B6%E5%89%82&action=edit&redlink=1" class="new" title="成熟抑制剂（页面不存在）">成熟抑制剂</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><span class="ilh-all" data-orig-title="贝韦立马" data-lang-code="en" data-lang-name="英语" data-foreign-title="Bevirimat"><span class="ilh-page"><a href="/w/index.php?title=%E8%B4%9D%E9%9F%A6%E7%AB%8B%E9%A9%AC&action=edit&redlink=1" class="new" title="贝韦立马（页面不存在）">贝韦立马</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Bevirimat" class="extiw" title="en:Bevirimat"><span lang="en" dir="auto">Bevirimat</span></a></span>）</span></span><sup>†</sup></li> <li>Vivecon<sup>†</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;"><a href="/wiki/%E8%9B%8B%E7%99%BD%E9%85%B6%E6%8A%91%E5%88%B6%E5%89%82" title="蛋白酶抑制剂">蛋白酶抑制剂</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;">第一代</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E5%AE%89%E6%99%AE%E9%82%A3%E9%9F%A6" title="安普那韦">安普那韦</a><sup>‡</sup></li> <li><a href="/wiki/%E7%A6%8F%E6%B2%99%E9%82%A3%E9%9F%A6" title="福沙那韦">福沙那韦</a>°</li> <li><span class="ilh-all" data-orig-title="茚地那韦" data-lang-code="en" data-lang-name="英语" data-foreign-title="Indinavir"><span class="ilh-page"><a href="/w/index.php?title=%E8%8C%9A%E5%9C%B0%E9%82%A3%E9%9F%A6&action=edit&redlink=1" class="new" title="茚地那韦（页面不存在）">茚地那韦</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Indinavir" class="extiw" title="en:Indinavir"><span lang="en" dir="auto">Indinavir</span></a></span>）</span></span><sup>‡</sup><sup>§</sup></li> <li><a href="/wiki/%E6%B4%9B%E5%8C%B9%E9%82%A3%E9%9F%8B" title="洛匹那韋">洛匹那韋</a>°<sup>§</sup></li> <li><a href="/wiki/%E5%A5%88%E9%9D%9E%E9%82%A3%E9%9F%A6" title="奈非那韦">奈非那韦</a><sup>§</sup></li> <li><a href="/wiki/%E5%88%A9%E6%89%98%E9%82%A3%E9%9F%8B" title="利托那韋">利托那韦</a><sup>§</sup></li> <li><a href="/wiki/%E6%B2%99%E5%A5%8E%E9%82%A3%E9%9F%A6" title="沙奎那韦">沙奎那韦</a><sup>§</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;">第二代</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E9%98%BF%E6%89%8E%E9%82%A3%E9%9F%A6" title="阿扎那韦">阿扎那韦</a>°</li> <li><a href="/wiki/%E8%BE%BE%E8%8A%A6%E9%82%A3%E9%9F%A6" title="达芦那韦">达芦那韦</a></li> <li><a href="/wiki/%E6%9B%BF%E6%8B%89%E9%82%A3%E9%9F%A6" title="替拉那韦">替拉那韦</a></li> <li>TMC-310911<sup>§</sup></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;"><span class="ilh-all" data-orig-title="抗逆转录病毒复方药列表" data-lang-code="en" data-lang-name="英语" data-foreign-title="List of antiretroviral fixed-dose combinations"><span class="ilh-page"><a href="/w/index.php?title=%E6%8A%97%E9%80%86%E8%BD%AC%E5%BD%95%E7%97%85%E6%AF%92%E5%A4%8D%E6%96%B9%E8%8D%AF%E5%88%97%E8%A1%A8&action=edit&redlink=1" class="new" title="抗逆转录病毒复方药列表（页面不存在）">複方</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/List_of_antiretroviral_fixed-dose_combinations" class="extiw" title="en:List of antiretroviral fixed-dose combinations"><span lang="en" dir="auto">List of antiretroviral fixed-dose combinations</span></a></span>）</span></span><a href="/wiki/%E8%A4%87%E6%96%B9%E8%97%A5" title="複方藥">藥</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E6%8B%89%E7%B1%B3%E5%A4%AB%E5%AE%9A/%E9%BD%90%E5%A4%9A%E5%A4%AB%E5%AE%9A" title="拉米夫定/齐多夫定">齐多拉米双夫定</a></li> <li><a href="/w/index.php?title=%E9%98%BF%E5%B7%B4%E5%8D%A1%E9%9F%A6%E5%8F%8C%E5%A4%AB%E5%AE%9A&action=edit&redlink=1" class="new" title="阿巴卡韦双夫定（页面不存在）">阿巴卡韦双夫定</a>（Trizivir）</li> <li><a href="/wiki/%E4%BE%9D%E6%B3%95%E9%9F%8B%E4%BE%96/%E6%81%A9%E6%9B%B2%E4%BB%96%E6%BF%B1/%E6%9B%BF%E8%AB%BE%E7%A6%8F%E9%9F%8B" title="依法韋侖/恩曲他濱/替諾福韋">依法韦仑/恩曲他滨/替诺福韦</a>（Atripla）</li> <li><a href="/wiki/%E6%81%A9%E6%9B%B2%E4%BB%96%E6%BB%A8/%E6%9B%BF%E8%AF%BA%E7%A6%8F%E9%9F%A6" title="恩曲他滨/替诺福韦">恩曲他滨/替诺福韦</a></li> <li><a href="/w/index.php?title=%E6%81%A9%E6%9B%B2%E4%BB%96%E6%BB%A8/%E4%B8%99%E9%85%9A%E6%9B%BF%E8%AF%BA%E7%A6%8F%E9%9F%A6&action=edit&redlink=1" class="new" title="恩曲他滨/丙酚替诺福韦（页面不存在）">恩曲他滨/丙酚替诺福韦</a></li> <li><a href="/wiki/%E9%98%BF%E5%B7%B4%E5%8D%A1%E9%9F%8B/%E6%8B%89%E7%B1%B3%E5%A4%AB%E5%AE%9A" title="阿巴卡韋/拉米夫定">阿巴卡韦/拉米夫定</a>（Epzicom）</li> <li><a href="/wiki/%E6%B4%9B%E5%8C%B9%E9%82%A3%E9%9F%8B/%E5%88%A9%E6%89%98%E9%82%A3%E9%9F%8B" title="洛匹那韋/利托那韋">洛匹那韋/利托那韋</a></li> <li><a href="/w/index.php?title=%E5%A4%9A%E6%9B%BF%E6%8B%89%E9%9F%A6/%E6%8B%89%E7%B1%B3%E5%A4%AB%E5%AE%9A/%E9%98%BF%E5%B7%B4%E5%8D%A1%E9%9F%A6&action=edit&redlink=1" class="new" title="多替拉韦/拉米夫定/阿巴卡韦（页面不存在）">多替拉韦/拉米夫定/阿巴卡韦</a></li> <li><a href="/wiki/%E5%A4%9A%E6%9B%BF%E6%8B%89%E9%9F%8B/%E6%8B%89%E7%B1%B3%E5%A4%AB%E5%AE%9A/%E6%9B%BF%E8%AB%BE%E7%A6%8F%E9%9F%8B" title="多替拉韋/拉米夫定/替諾福韋">多替拉韦/拉米夫定/替诺福韦</a></li> <li><a href="/w/index.php?title=%E5%A4%9A%E6%9B%BF%E6%8B%89%E9%9F%A6/%E6%8B%89%E7%B1%B3%E5%A4%AB%E5%AE%9A&action=edit&redlink=1" class="new" title="多替拉韦/拉米夫定（页面不存在）">多替拉韦/拉米夫定</a></li> <li><a href="/w/index.php?title=%E5%A4%9A%E6%9B%BF%E6%8B%89%E9%9F%A6/%E5%88%A9%E5%8C%B9%E9%9F%A6%E6%9E%97&action=edit&redlink=1" class="new" title="多替拉韦/利匹韦林（页面不存在）">多替拉韦/利匹韦林</a></li> <li><a href="/w/index.php?title=%E6%8B%89%E7%B1%B3%E5%A4%AB%E5%AE%9A/%E6%9B%BF%E8%AF%BA%E7%A6%8F%E9%9F%A6&action=edit&redlink=1" class="new" title="拉米夫定/替诺福韦（页面不存在）">拉米夫定/替诺福韦</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;">研发中的化合物</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0px"><div style="padding:0em 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;"><a href="/w/index.php?title=%E8%84%B1%E5%A3%B3%E6%8A%91%E5%88%B6%E5%89%82&action=edit&redlink=1" class="new" title="脱壳抑制剂（页面不存在）">脱壳抑制剂</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px"><div style="padding:0em 0.25em">TRIM5alpha (gene)</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;"><a href="/w/index.php?title=%E8%BD%AC%E5%BD%95%E6%8A%91%E5%88%B6%E5%89%82&action=edit&redlink=1" class="new" title="转录抑制剂（页面不存在）">转录抑制剂</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px"><div style="padding:0em 0.25em">Tat_(HIV)#Clinical_significance</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;"><a href="/w/index.php?title=%E5%9F%BA%E5%9B%A0%E7%BF%BB%E8%AF%91%E6%8A%91%E5%88%B6%E5%89%82&action=edit&redlink=1" class="new" title="基因翻译抑制剂（页面不存在）">基因翻译抑制剂</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px"><div style="padding:0em 0.25em"><a href="/w/index.php?title=%E5%A4%A9%E8%8A%B1%E7%B2%89%E8%9B%8B%E7%99%BD&action=edit&redlink=1" class="new" title="天花粉蛋白（页面不存在）">天花粉蛋白</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;">其他</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E6%8A%97%E4%BD%93%E9%85%B6" title="抗体酶">抗体酶</a></li> <li>BIT225</li> <li>Calanolide A</li> <li>Ceragenin</li> <li>Cyanovirin-N</li> <li>Diarylpyrimidines</li> <li><a href="/wiki/%E8%A1%A8%E6%B2%A1%E9%A3%9F%E5%AD%90%E5%84%BF%E8%8C%B6%E7%B4%A0%E6%B2%A1%E9%A3%9F%E5%AD%90%E9%85%B8%E9%85%AF" title="表没食子儿茶素没食子酸酯">表没食子儿茶素没食子酸酯</a></li> <li><a href="/wiki/%E8%86%A6%E7%94%B2%E9%85%B8" title="膦甲酸">膦甲酸</a></li> <li>Fosdeviridine<sup>†</sup></li> <li>Griffithsin</li> <li><a href="/wiki/%E7%BE%9F%E5%9F%BA%E8%84%B2" title="羟基脲">羟基脲</a></li> <li><span class="ilh-all" data-orig-title="KP-1461" data-lang-code="en" data-lang-name="英语" data-foreign-title="KP-1461"><span class="ilh-page"><a href="/w/index.php?title=KP-1461&action=edit&redlink=1" class="new" title="KP-1461（页面不存在）">KP-1461</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/KP-1461" class="extiw" title="en:KP-1461"><span lang="en" dir="auto">KP-1461</span></a></span>）</span></span><sup>†</sup></li> <li><span class="ilh-all" data-orig-title="米替福新" data-lang-code="en" data-lang-name="英语" data-foreign-title="Miltefosine"><span class="ilh-page"><a href="/w/index.php?title=%E7%B1%B3%E6%9B%BF%E7%A6%8F%E6%96%B0&action=edit&redlink=1" class="new" title="米替福新（页面不存在）">米替福新</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Miltefosine" class="extiw" title="en:Miltefosine"><span lang="en" dir="auto">Miltefosine</span></a></span>）</span></span></li> <li>Portmanteau inhibitor</li> <li>Scytovirin</li> <li><span class="ilh-all" data-orig-title="塞利西利" data-lang-code="en" data-lang-name="英语" data-foreign-title="Seliciclib"><span class="ilh-page"><a href="/w/index.php?title=%E5%A1%9E%E5%88%A9%E8%A5%BF%E5%88%A9&action=edit&redlink=1" class="new" title="塞利西利（页面不存在）">塞利西利</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Seliciclib" class="extiw" title="en:Seliciclib"><span lang="en" dir="auto">Seliciclib</span></a></span>）</span></span><sup>†</sup></li> <li><span class="ilh-all" data-orig-title="协同增强剂" data-lang-code="en" data-lang-name="英语" data-foreign-title="Synergistic enhancer (antiretroviral)"><span class="ilh-page"><a href="/w/index.php?title=%E5%8D%8F%E5%90%8C%E5%A2%9E%E5%BC%BA%E5%89%82&action=edit&redlink=1" class="new" title="协同增强剂（页面不存在）">协同增强剂</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Synergistic_enhancer_(antiretroviral)" class="extiw" title="en:Synergistic enhancer (antiretroviral)"><span lang="en" dir="auto">Synergistic enhancer (antiretroviral)</span></a></span>）</span></span></li> <li>Tre recombinase</li> <li><a href="/w/index.php?title=%E9%94%8C%E6%8C%87%E8%9B%8B%E7%99%BD%E8%BD%AC%E5%BD%95%E5%9B%A0%E5%AD%90&action=edit&redlink=1" class="new" title="锌指蛋白转录因子（页面不存在）">锌指蛋白转录因子</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:PowderBlue;">研发失败的化合物</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E9%98%BF%E6%8B%89%E9%9F%A6%E7%BD%97" title="阿拉韦罗">阿拉韦罗</a></li> <li><a href="/wiki/%E9%98%BF%E6%9B%BF%E9%9F%A6%E5%95%B6" title="阿替韦啶">阿替韦啶</a></li> <li><a href="/wiki/%E5%B8%83%E7%91%9E%E9%82%A3%E9%9F%A6" title="布瑞那韦">布瑞那韦</a></li> <li><a href="/wiki/%E5%8D%A1%E6%99%AE%E9%9F%A6%E6%9E%97" title="卡普韦林">卡普韦林</a></li> <li><a href="/wiki/%E5%8F%B3%E8%89%BE%E5%A4%AB%E4%BB%96%E6%BB%A8" title="右艾夫他滨">右艾夫他滨</a></li> <li><a href="/wiki/%E5%86%B3%E6%98%94%E9%82%A3%E9%9F%A6" title="决昔那韦">决昔那韦</a></li> <li><a href="/wiki/%E6%8B%89%E8%A5%BF%E9%82%A3%E9%9F%A6" title="拉西那韦">拉西那韦</a></li> <li><a href="/wiki/%E4%B9%99%E7%B1%B3%E9%9F%A6%E6%9E%97" title="乙米韦林">乙米韦林</a></li> <li><span class="ilh-all" data-orig-title="来司韦林" data-lang-code="en" data-lang-name="英语" data-foreign-title="Lersivirine"><span class="ilh-page"><a href="/w/index.php?title=%E6%9D%A5%E5%8F%B8%E9%9F%A6%E6%9E%97&action=edit&redlink=1" class="new" title="来司韦林（页面不存在）">来司韦林</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Lersivirine" class="extiw" title="en:Lersivirine"><span lang="en" dir="auto">Lersivirine</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="洛德腺苷" data-lang-code="en" data-lang-name="英语" data-foreign-title="Lodenosine"><span class="ilh-page"><a href="/w/index.php?title=%E6%B4%9B%E5%BE%B7%E8%85%BA%E8%8B%B7&action=edit&redlink=1" class="new" title="洛德腺苷（页面不存在）">洛德腺苷</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Lodenosine" class="extiw" title="en:Lodenosine"><span lang="en" dir="auto">Lodenosine</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="洛韦胺" data-lang-code="en" data-lang-name="英语" data-foreign-title="Loviride"><span class="ilh-page"><a href="/w/index.php?title=%E6%B4%9B%E9%9F%A6%E8%83%BA&action=edit&redlink=1" class="new" title="洛韦胺（页面不存在）">洛韦胺</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Loviride" class="extiw" title="en:Loviride"><span lang="en" dir="auto">Loviride</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="莫折那韦" data-lang-code="en" data-lang-name="英语" data-foreign-title="Mozenavir"><span class="ilh-page"><a href="/w/index.php?title=%E8%8E%AB%E6%8A%98%E9%82%A3%E9%9F%A6&action=edit&redlink=1" class="new" title="莫折那韦（页面不存在）">莫折那韦</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Mozenavir" class="extiw" title="en:Mozenavir"><span lang="en" dir="auto">Mozenavir</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="帕立那韦" data-lang-code="en" data-lang-name="英语" data-foreign-title="Palinavir"><span class="ilh-page"><a href="/w/index.php?title=%E5%B8%95%E7%AB%8B%E9%82%A3%E9%9F%A6&action=edit&redlink=1" class="new" title="帕立那韦（页面不存在）">帕立那韦</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Palinavir" class="extiw" title="en:Palinavir"><span lang="en" dir="auto">Palinavir</span></a></span>）</span></span></li> <li><span class="ilh-all" data-orig-title="替利那韦" data-lang-code="en" data-lang-name="英语" data-foreign-title="Telinavir"><span class="ilh-page"><a href="/w/index.php?title=%E6%9B%BF%E5%88%A9%E9%82%A3%E9%9F%A6&action=edit&redlink=1" class="new" title="替利那韦（页面不存在）">替利那韦</a></span><span class="noprint ilh-comment">（<span class="ilh-lang">英语</span><span class="ilh-colon">：</span><span class="ilh-link"><a href="https://en.wikipedia.org/wiki/Telinavir" class="extiw" title="en:Telinavir"><span lang="en" dir="auto">Telinavir</span></a></span>）</span></span></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background:transparent;"><div>°<a href="/wiki/%E7%BE%8E%E5%9B%BD%E5%8D%AB%E7%94%9F%E5%8F%8A%E5%85%AC%E5%85%B1%E6%9C%8D%E5%8A%A1%E9%83%A8" title="美国卫生及公共服务部">DHHS</a>推荐一线治疗药物. <sup>†</sup> <a href="/wiki/%E8%87%A8%E5%BA%8A%E8%A9%A6%E9%A9%97" title="臨床試驗">臨床試驗</a>中. <sup>‡</sup>很少用的药物. <sup>§</sup> <a href="/wiki/%E4%B8%96%E7%95%8C%E5%8D%AB%E7%94%9F%E7%BB%84%E7%BB%87%E5%9F%BA%E6%9C%AC%E8%8D%AF%E7%89%A9%E6%A0%87%E5%87%86%E6%B8%85%E5%8D%95" title="世界卫生组织基本药物标准清单">WHO基本药物</a></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1&useformat=desktop" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">检索自“<a dir="ltr" href="https://zh.wikipedia.org/w/index.php?title=拉替拉韦&oldid=79592132">https://zh.wikipedia.org/w/index.php?title=拉替拉韦&oldid=79592132</a>”</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" 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