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KEGG DRUG: Tolpropamine
<!doctype html> <html><head> <title>KEGG DRUG: Tolpropamine</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1743511674"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1743511674"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1743511674" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « '+hide; 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} } } function Link_XtrctSeq2(form) { var dna_from; var dna_to; var dna_len; var plus_up = Number(form.XtrctSeq_UP.value) ; var plus_down = Number(form.XtrctSeq_DOWN.value); var vector = Number(form.VECTOR.value); var org = form.ORG.value; var chr = form.CHR.value; var kid = form.KEGGID.value; var url; if (plus_up == 0 && plus_down == 0) { url = "/entry/-f+-n+n+" + kid; } else { if (vector == 1) { dna_from = Number(form.FROM.value) - plus_up; dna_to = Number(form.TO.value) + plus_down; } else { dna_from = Number(form.FROM.value) - plus_down; dna_to = Number(form.TO.value) + plus_up; } url = "/dbget-bin/cut_sequence_genes.pl?FROM=" + dna_from + "&TO=" + dna_to +"&VECTOR=" + vector + "&ORG=" + org; if (chr) url += "&CHR=" + chr; } //window.open( url, "_self" ); location.href = url; } function go_taxonomy(form,params){ for(var key in params){ if(form[key]){ form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="650"><tr><td width=70><a href="/kegg/drug"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg5.gif"></a></td><td> </td><td><a name="drug:D07196"></a><font class="title5">DRUG: Tolpropamine</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_drug.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/entry/" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr5 w1"> <table width="650" class="w2"> <tr><th class="th50 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td50 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">D07196 Drug <br> </span></code></td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td51 defd"><div class="cel">Tolpropamine (INN)</div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Formula</span></th> <td class="td50 defd"><div class="cel">C18H23N<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Exact mass</span></th> <td class="td51 defd"><div class="cel">253.1831<br> </div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Mol weight</span></th> <td class="td50 defd"><div class="cel">253.38<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Structure</span></th> <td class="td51 defd"><a href="/Fig/drug/D07196.gif"><img name="img0" src="/Fig/drug/D07196.gif" style="max-width:600px" border=0></a><br> <button class="btn" onclick="location.href='/entry/-f+m+D07196';return false;">Mol file</button><button class="btn" onclick="location.href='/entry/-f+k+D07196';return false;">KCF file</button><button class="btn" onclick="location.href='https://www.genome.jp/tools-bin/strsearch_view?ENTRY=D07196&PROGRAM=simcomp&DATABASE=drug';return false;">DB search</button></td></tr> <tr><th class="th50 deft tal vmid"><span class="nowrap">Simcomp</span></th> <td class="td50 defd"><button class="btn" onclick="location.href='/kegg-bin/simcomp_list?id=D07196';return false;">Neighbor</button></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Remark</span></th> <td class="td51 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ATC code: </span></td><td><a href="/brite/br08303+D07196">D04AA12</a></td></tr></table></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Efficacy</span></th> <td class="td50 defd"><div class="cel">Antiallergic, H1 receptor antagonist</div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Target</span></th> <td class="td51 defd"><div class="cel">HRH1 [HSA:<a href="/entry/hsa:3269">3269</a>] [KO:<a href="/entry/K04149">K04149</a>]</div></td></tr> <tr><th class="th50 rept tal vtop"><span class="nowrap"> Pathway</span></th> <td class="td50 repd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa04020+3269">hsa04020</a> </span></td><td>Calcium signaling pathway</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa04080+3269">hsa04080</a> </span></td><td>Neuroactive ligand-receptor interaction</td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Brite</span></th> <td class="td51 defd"><div class="cel"><span class="nowrap">Anatomical Therapeutic Chemical (ATC) classification [BR:<a href="/brite/br08303+D07196">br08303</a>]<br> D DERMATOLOGICALS<br> D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.<br> D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.<br> D04AA Antihistamines for topical use<br> D04AA12 Tolpropamine<br> D07196 Tolpropamine (INN)<br> Target-based classification of drugs [BR:<a href="/brite/br08310+D07196">br08310</a>]<br> G Protein-coupled receptors<br> Rhodopsin family<br> Histamine<br> HRH1<br> D07196 Tolpropamine (INN)<br> </span></div><button class="btn" onclick="location.href='/kegg-bin/search_brite?option=-a&search_string=D07196';return false;">BRITE hierarchy</button></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td50 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CAS: </span></td><td>5632-44-0</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PubChem: </span></td><td><a href="https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=51091534">51091534</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">LigandBox: </span></td><td><a href="http://www.mypresto5.com/ligandbox202210/cgi-bin/liginf.cgi?id=D07196&source=KEGG_DRUG">D07196</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">NIKKAJI: </span></td><td><a href="https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J8.034I">J8.034I</a></td></tr></table></td></tr> <tr><th class="th51 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td51 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?drug+D07196';return false;">All DBs</button></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">KCF data</span></th> <td class="td50 defd"><button class="btn" id="kcfb1">Show</button><div class="kcfd" id="kcfd1"><br>ATOM 19<br> 1 C8x C 19.6466 -20.3863<br> 2 C8x C 18.4340 -21.0860<br> 3 C8x C 17.2329 -20.4051<br> 4 C8x C 17.2445 -19.0246<br> 5 C8y C 18.4571 -18.3248<br> 6 C8x C 19.6581 -19.0057<br> 7 C1c C 18.4942 -16.8487<br> 8 C8y C 17.2932 -16.1678<br> 9 C8x C 16.0200 -16.9025<br> 10 C8x C 14.8189 -16.2217<br> 11 C8y C 14.8655 -14.7805<br> 12 C8x C 16.0687 -14.0458<br> 13 C8x C 17.3047 -14.7872<br> 14 C1b C 19.6462 -16.1839<br> 15 C1b C 20.8823 -16.9254<br> 16 N1c N 22.0949 -16.2257<br> 17 C1a C 22.0714 -14.7845<br> 18 C1a C 23.2959 -16.9065<br> 19 C1a C 13.5944 -14.0996<br> BOND 20<br> 1 1 2 2<br> 2 2 3 1<br> 3 3 4 2<br> 4 4 5 1<br> 5 5 6 2<br> 6 1 6 1<br> 7 5 7 1<br> 8 7 8 1<br> 9 8 9 2<br> 10 9 10 1<br> 11 10 11 2<br> 12 11 12 1<br> 13 12 13 2<br> 14 8 13 1<br> 15 7 14 1<br> 16 14 15 1<br> 17 15 16 1<br> 18 16 17 1<br> 19 16 18 1<br> 20 11 19 1<br> </div></td></tr> </table></td></tr></table> <br><span style="font-size:12px"><a href="/entry/dr_ja:D07196">» Japanese version</a> <a href="javascript:history.back();">» Back</a></span><br><br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>