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.team-second-header { font-size: 40px !important; line-height: 50px !important; margin-top: 68px; margin-bottom: 20px; margin-left: 0; } .member-image { margin-left: 0; margin-bottom: 20px; } .member-description { margin-right: 0; } /* About us */ .about-content-col .intro-para p { font-size: 16px; line-height: 24px; } .about-content-col .intro-para h2 { font-size: 22px; line-height: 32px; } /* Product page */ .navinci-bg-left.vc_custom_1633423029422, .navinci-bg-left.vc_custom_1633423043835 { background-position: left !important; background-size: cover !important; } .navinci-bg-right.vc_custom_1633423010215, .navinci-bg-right.vc_custom_1633423017590 { background-position: right !important; background-size: cover !important; } .navinci-bg-left::before, .navinci-bg-right::before { content: ""; display: block; position: absolute; top: 0; right: 0; bottom: 0; left: 0; background-color: rgba(0,0,0,0.4); width: 100%; height: 100%; } } // ------- EVENTS PAGE -------- //21st CIMT row .clickable-row { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .clickable-row:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // -- PLA workshop at rudbeck row .workshop-rudbeck-row { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .workshop-rudbeck-row:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- AACR 2024 row .aacr-2024-row { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .aacr-2024-row:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- WEBINAR MARCH 26 row .webinar-march26 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .webinar-march26:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- ITOC-2024 row .itoc-2024 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .itoc-2024:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- EAI-2024 row .eai-2024 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .eai-2024:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- spatial biology east coast 2024 row .sbec-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .sbec-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- festival of genomics row .fgb-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .fgb-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- VIB Spatial Omics row .vib-so-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .vib-so-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- EACR row .eacr-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .eacr-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- milano row .milano-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .milano-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- milner row .milner-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .milner-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- mbc row .mbc-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .mbc-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- nsh row .nsh-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .nsh-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- ehf row .ehf-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .ehf-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- spatial europe row .spatialeurope-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .spatialeurope-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- spatial scilifelabs row .spatialscilifelabs-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .spatialscilifelabs-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- neuroscience row .neuroscience-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .neuroscience-24:hover { 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href="https://navinci.se/applications/assay-database/" title="Assay database"><span itemprop="name">Assay database</span></a><meta itemprop="position" content="3" /></li><li class="current" itemprop="itemListElement" itemscope itemtype="https://schema.org/ListItem"><span itemprop="name">Detection of HER2</span><meta itemprop="position" content="4" /></li></ol></div></div></div></div></div><section data-vc-full-width="true" data-vc-full-width-init="false" class="vc_section vc_custom_1701804021606"><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1 vc_col-lg-1 vc_col-md-1 vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-7 vc_col-lg-7 vc_col-md-10 vc_hidden-md vc_hidden-sm vc_col-xs-12 vc_hidden-xs"><div class="vc_column-inner vc_custom_1703099213583"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h1 style="color: #000000; font-size: 30px; line-height: 38px;">Precise and specific detection of HER2</h1> </div> </div> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p style="font-size: 16px; line-height: 28px;"><strong>HER2 expression plays a key role in various cancers, with overexpression linked to uncontrolled cell growth and metastasis and also its potential as a therapeutic target. Navinci’s advanced <em>in situ</em> proximity ligation technology can provide accurate detection of HER2 and therefore insights into prognosis and treatment decisions. Get your protocol below.</strong></p> </div> </div> </div></div></div></div></section><div class="vc_row-full-width vc_clearfix"></div><section data-vc-full-width="true" data-vc-full-width-init="false" class="vc_section vc_custom_1701804021606"><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1 vc_hidden-lg vc_col-xs-12"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-10 vc_hidden-lg vc_col-md-10 vc_col-xs-12"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h1 style="color: #000000; font-size: 30px; line-height: 38px;">Precise and specific detection of HER2</h1> </div> </div> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p style="font-size: 16px; line-height: 28px;"><strong>HER2 expression plays a key role in various cancers, with overexpression linked to uncontrolled cell growth and metastasis and also its potential as a therapeutic target. Navinci’s advanced <em>in situ</em> proximity ligation technology can provide accurate detection of HER2 and therefore insights into prognosis and treatment decisions. Get your protocol below.</strong></p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div></section><div class="vc_row-full-width vc_clearfix"></div><div data-vc-full-width="true" data-vc-full-width-init="false" data-vc-stretch-content="true" class="vc_row wpb_row vc_row-fluid vc_row-no-padding"><div class="wpb_column vc_column_container vc_col-sm-12 vc_hidden-lg"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201035%20768'%3E%3C/svg%3E" width="1035" height="768" alt="Positive HER2 in malignant breast cancer detected with NaveniBright" title="Positive HER2 in malignant breast cancer detected with NaveniBright" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/positive-her2-in-malignant-breast-cancer-detected-with-navenibright/" data-lazy-src="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-NaveniBright-1-1035x768.jpg" /><noscript><img decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-NaveniBright-1-1035x768.jpg" width="1035" height="768" alt="Positive HER2 in malignant breast cancer detected with NaveniBright" title="Positive HER2 in malignant breast cancer detected with NaveniBright" loading="lazy" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/positive-her2-in-malignant-breast-cancer-detected-with-navenibright/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element vc_custom_1702982157511" > <div class="wpb_wrapper"> <p style="font-size: 14px; line-height: 20px; text-align: center;"><em>In situ</em> detection of HER2 in malignant breast cancer tissue using NaveniBright™ HRP</p> </div> </div> </div></div></div></div><div class="vc_row-full-width vc_clearfix"></div><section class="vc_section"><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 vc_col-lg-6 vc_col-md-12 vc_hidden-md vc_hidden-sm vc_col-xs-12"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h2 style="color: #000000; font-size: 24px; line-height: 28px;">ErbB/HER receptors in cellular signaling complexity</h2> <p style="font-size: 16px; line-height: 28px;">The human epidermal growth factor receptors (ErbB/HER) consists of four cell surface glycoproteins termed ErbB1/HER1, ErbB2/Neu/HER2, ErbB3/HER3 and ErbB4/HER4 (1,2). ErbB receptors are expressed in a variety of tissues of epithelial, mesenchymal and neuronal origin, where they play fundamental roles in development, proliferation and differentiation via multiple signal transduction.  Binding of a ligand to its cognate ErbB receptor induces formation of homo- or heterodimer complexes, which activates receptor tyrosine kinase activity, leading to increased downstream RAS/MAPK, PI3K/AKT, and JAK/STAT signaling (1).</p> <h2 style="color: #000000; font-size: 24px; line-height: 28px;">The role of HER2 in diverse cancers</h2> <p style="font-size: 16px; line-height: 28px;">The human epidermal growth factor receptor family of receptors plays a central role in the pathogenesis of several human cancers where they facilitate uncontrolled cell growth and tumorigenesis. Overexpression, amplification, and activating point mutations of Erb/Her family of receptors promote oncogenesis (1). The tumorigenic action of HER2 is not limited to a potential proliferative effect as HER2 has been shown to be a metastasis-promoting factor (3-5).</p> <p style="font-size: 16px; line-height: 28px;">Most of the studies on HER2 have been carried out in breast cancer after it was found to induce mammary carcinogenesis in vitro and in vivo (6, 7). Overexpression of HER2 is observed in 25–30% of breast cancers and is associated with an aggressive clinical phenotype (1). However, HER2 overexpression also occurs in other forms of cancers such as stomach, ovary, uterine serous endometrial carcinoma, colon, bladder, lung, uterine cervix, head and neck, and esophagus (8,9).</p> <p style="font-size: 16px; line-height: 28px;">Apart from its role in development of various cancers, it has been intensely evaluated as a therapeutic target. It has also served as a prognostic and predictive biomarker in breast and gastric/gastroesophageal cancers, which have improved the clinical outcome and therapies directed against HER2 have revolutionized the treatment of HER2 overexpressing breast and gastric cancers (5).</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-4 vc_col-lg-4 vc_hidden-md vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img fetchpriority="high" decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-NaveniBright-2-690x950.jpg" width="690" height="950" alt="Positive HER2 in malignant breast cancer detected with NaveniBright 2" title="Positive HER2 in malignant breast cancer detected with NaveniBright 2" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/positive-her2-in-malignant-breast-cancer-detected-with-navenibright-2/" /></div> </figure> </div> <div class="wpb_text_column wpb_content_element vc_custom_1702982167155" > <div class="wpb_wrapper"> <p style="font-size: 14px; text-align: center; line-height: 20px;"><em>In situ</em> detection of HER2 in malignant breast cancer tissue using NaveniBright™ HRP</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-10 vc_hidden-lg vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h2 style="color: #000000; font-size: 24px; line-height: 28px;">ErbB/HER receptors in cellular signaling complexity</h2> <p style="font-size: 16px; line-height: 28px;">The human epidermal growth factor receptors (ErbB/HER) consists of four cell surface glycoproteins termed ErbB1/HER1, ErbB2/Neu/HER2, ErbB3/HER3 and ErbB4/HER4 (1,2). ErbB receptors are expressed in a variety of tissues of epithelial, mesenchymal and neuronal origin, where they play fundamental roles in development, proliferation and differentiation via multiple signal transduction.  Binding of a ligand to its cognate ErbB receptor induces formation of homo- or heterodimer complexes, which activates receptor tyrosine kinase activity, leading to increased downstream RAS/MAPK, PI3K/AKT, and JAK/STAT signaling (1).</p> <h2 style="color: #000000; font-size: 24px; line-height: 28px;">The role of HER2 in diverse cancers</h2> <p style="font-size: 16px; line-height: 28px;">The human epidermal growth factor receptor family of receptors plays a central role in the pathogenesis of several human cancers where they facilitate uncontrolled cell growth and tumorigenesis. Overexpression, amplification, and activating point mutations of Erb/Her family of receptors promote oncogenesis (1). The tumorigenic action of HER2 is not limited to a potential proliferative effect as HER2 has been shown to be a metastasis-promoting factor (3-5).</p> <p style="font-size: 16px; line-height: 28px;">Most of the studies on HER2 have been carried out in breast cancer after it was found to induce mammary carcinogenesis in vitro and in vivo (6, 7). Overexpression of HER2 is observed in 25–30% of breast cancers and is associated with an aggressive clinical phenotype (1). However, HER2 overexpression also occurs in other forms of cancers such as stomach, ovary, uterine serous endometrial carcinoma, colon, bladder, lung, uterine cervix, head and neck, and esophagus (8,9).</p> <p style="font-size: 16px; line-height: 28px;">Apart from its role in development of various cancers, it has been intensely evaluated as a therapeutic target. It has also served as a prognostic and predictive biomarker in breast and gastric/ gastroesophageal cancers, which have improved the clinical outcome and therapies directed against HER2 have revolutionized the treatment of HER2 overexpressing breast and gastric cancers (5).</p> </div> </div> </div></div></div></div><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-5 vc_hidden-md vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img fetchpriority="high" decoding="async" width="4145" height="4254" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%204145%204254'%3E%3C/svg%3E" class="vc_single_image-img attachment-full" alt="detection of HER2 illustration" title="Detection of HER2" data-lazy-srcset="https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2.png 4145w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-600x616.png 600w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-292x300.png 292w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-998x1024.png 998w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-768x788.png 768w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-1497x1536.png 1497w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-1996x2048.png 1996w" data-lazy-sizes="(max-width: 4145px) 100vw, 4145px" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/detection-of-her2/" data-lazy-src="https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2.png" /><noscript><img fetchpriority="high" decoding="async" width="4145" height="4254" src="https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2.png" class="vc_single_image-img attachment-full" alt="detection of HER2 illustration" title="Detection of HER2" srcset="https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2.png 4145w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-600x616.png 600w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-292x300.png 292w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-998x1024.png 998w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-768x788.png 768w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-1497x1536.png 1497w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-1996x2048.png 1996w" sizes="(max-width: 4145px) 100vw, 4145px" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/detection-of-her2/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element vc_custom_1702978881075" > <div class="wpb_wrapper"> <p style="font-size: 14px; text-align: center; line-height: 20px;"><strong>Figure 1</strong>. Applying the target-specific Naveni® <em>in situ</em> proximity ligation assay on Her2. Only if the Navenibodies are in close proximity will they generate a rolling circle amplification reaction, leading to a strong and distinct signal</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-5 vc_hidden-md vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div></section><div data-vc-full-width="true" data-vc-full-width-init="false" data-vc-stretch-content="true" class="vc_row wpb_row vc_row-fluid vc_row-no-padding"><div class="wpb_column vc_column_container vc_col-sm-1 vc_hidden-lg"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-10 vc_hidden-lg vc_col-md-10 vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img fetchpriority="high" decoding="async" width="4145" height="4254" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%204145%204254'%3E%3C/svg%3E" class="vc_single_image-img attachment-full" alt="detection of HER2 illustration" title="Detection of HER2" data-lazy-srcset="https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2.png 4145w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-600x616.png 600w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-292x300.png 292w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-998x1024.png 998w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-768x788.png 768w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-1497x1536.png 1497w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-1996x2048.png 1996w" data-lazy-sizes="(max-width: 4145px) 100vw, 4145px" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/detection-of-her2/" data-lazy-src="https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2.png" /><noscript><img fetchpriority="high" decoding="async" width="4145" height="4254" src="https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2.png" class="vc_single_image-img attachment-full" alt="detection of HER2 illustration" title="Detection of HER2" srcset="https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2.png 4145w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-600x616.png 600w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-292x300.png 292w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-998x1024.png 998w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-768x788.png 768w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-1497x1536.png 1497w, https://navinci.se/wp-content/uploads/2023/12/Detection-of-HER2-1996x2048.png 1996w" sizes="(max-width: 4145px) 100vw, 4145px" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/detection-of-her2/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element vc_custom_1702978895512" > <div class="wpb_wrapper"> <p style="font-size: 14px; text-align: center; line-height: 20px;"><strong>Figure 1</strong>. Applying the target-specific Naveni® <em>in situ</em> proximity ligation assay on Her2. Only if the Navenibodies are in close proximity will they generate a rolling circle amplification reaction, leading to a strong and distinct signal</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div><section class="vc_section"><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 vc_hidden-md vc_hidden-sm vc_col-xs-12"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h2 style="color: #000000; font-size: 24px; line-height: 28px;">Superior detection of HER2</h2> <p style="font-size: 16px; line-height: 28px;">The two methods currently approved testing for clinical use of HER2 are immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) (10), where the scoring method for HER2 expression is based on the cell membrane staining pattern. We have developed a superior target-specific <em>in situ</em> proximity ligation assay for the visualization of HER2 in tissues. The assay is optimized for single protein detection and features increased sensitivity and efficiency over traditional techniques. Signal will be generated as a result of dual antibody binding to two different epitopes on the same molecule and the subsequent binding of Navenibodies to them, which eliminates off-target effects and greatly improves signal-to-noise ratios compared to standard immunohistochemistry (IHC) (see application examples below). This makes Navincis’ optimized assay for HER2 detection a valuable tool for basic research, as well as an additional verification method in clinical testing with the potential of becoming a new standard.</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-5 vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-10 vc_hidden-lg vc_col-md-10 vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h2 style="color: #000000; font-size: 24px; line-height: 28px;">Superior detection of HER2</h2> <p style="font-size: 16px; line-height: 28px;">The two methods currently approved testing for clinical use of HER2 are immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) (10), where the scoring method for HER2 expression is based on the cell membrane staining pattern. We have developed a superior target-specific<em> in situ</em> proximity ligation assay for the visualization of HER2 in tissues. The assay is optimized for single protein detection and features increased sensitivity and efficiency over traditional techniques. Signal will be generated as a result of dual antibody binding to two different epitopes on the same molecule and the subsequent binding of Navenibodies to them, which eliminates off-target effects and greatly improves signal-to-noise ratios compared to standard immunohistochemistry (IHC) (see application examples below). This makes Navincis’ optimized assay for HER2 detection a valuable tool for basic research, as well as an additional verification method in clinical testing with the potential of becoming a new standard.</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div></section><section class="vc_section"><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 vc_hidden-md vc_hidden-sm vc_col-xs-12"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h3 style="color: #000000; font-size: 18px; line-height: 24px;">Application example – Detection of HER2, comparison Naveni technology vs IHC</h3> <p style="font-size: 16px; line-height: 28px;">Accurate detection of HER2 is essential. The application examples below compare the Naveni technology, utilizing a dual antibody recognition approach, with traditional IHC based on single antibodies.</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-5 vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-10 vc_hidden-lg vc_col-md-10 vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h3 style="color: #000000; font-size: 18px; line-height: 24px;">Application example – Detection of HER2, comparison Naveni technology vs IHC</h3> <p style="font-size: 16px; line-height: 28px;">Accurate detection of HER2 is essential. The application examples below compare the Naveni technology, utilizing a dual antibody recognition approach, with traditional IHC based on single antibodies.</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1 vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-5 vc_hidden-md vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_right"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201035%20768'%3E%3C/svg%3E" width="1035" height="768" alt="Positive HER2 in malignant breast cancer detected with NaveniBright" title="Positive HER2 in malignant breast cancer detected with NaveniBright" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/positive-her2-in-malignant-breast-cancer-detected-with-navenibright/" data-lazy-src="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-NaveniBright-1-1035x768.jpg" /><noscript><img decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-NaveniBright-1-1035x768.jpg" width="1035" height="768" alt="Positive HER2 in malignant breast cancer detected with NaveniBright" title="Positive HER2 in malignant breast cancer detected with NaveniBright" loading="lazy" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/positive-her2-in-malignant-breast-cancer-detected-with-navenibright/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element vc_custom_1702979460660" > <div class="wpb_wrapper"> <p style="font-size: 14px; text-align: center; line-height: 20px;"><em>In situ </em>proximity ligation assay detection of HER2 in breast tissue, showing positive staining in malignant tissue. Signals are visualised using NaveniBright</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-5 vc_hidden-md vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_right"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201035%20768'%3E%3C/svg%3E" width="1035" height="768" alt="Negative HER2 in breast tissue detected with NaveniBright" title="Negative HER2 in breast tissue detected with NaveniBright" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/negative-her2-in-breast-tissue-detected-with-navenibright/" data-lazy-src="https://navinci.se/wp-content/uploads/2023/12/Negative-HER2-in-breast-tissue-detected-with-NaveniBright-1035x768.jpg" /><noscript><img decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/12/Negative-HER2-in-breast-tissue-detected-with-NaveniBright-1035x768.jpg" width="1035" height="768" alt="Negative HER2 in breast tissue detected with NaveniBright" title="Negative HER2 in breast tissue detected with NaveniBright" loading="lazy" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/negative-her2-in-breast-tissue-detected-with-navenibright/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element vc_custom_1702979137175" > <div class="wpb_wrapper"> <p style="font-size: 14px; text-align: center; line-height: 20px;"><em>In situ </em>proximity ligation assay detection of HER2 in breast tissue, showing negative staining in healthy tissue. Signals are visualised using NaveniBright</p> </div> </div> </div></div></div></div></section><div data-vc-full-width="true" data-vc-full-width-init="false" data-vc-stretch-content="true" class="vc_row wpb_row vc_row-fluid vc_row-no-padding"><div class="wpb_column vc_column_container vc_col-sm-12 vc_hidden-lg vc_col-xs-12"><div class="vc_column-inner"><div class="wpb_wrapper"><style type="text/css" data-type="the7_shortcodes-inline-css">.gallery-carousel-shortcode.gallery-carousel-shortcode-id-b92313f65802c5f5cda12aeac6abd3bd .owl-nav a { width: 36px; height: 36px; border-radius: 500px; } .dt-arrow-border-on.gallery-carousel-shortcode.gallery-carousel-shortcode-id-b92313f65802c5f5cda12aeac6abd3bd .owl-nav a:not(:hover):before { border-width: 0px; } .dt-arrow-hover-border-on.gallery-carousel-shortcode.gallery-carousel-shortcode-id-b92313f65802c5f5cda12aeac6abd3bd .owl-nav a:hover:after { border-width: 0px; } .gallery-carousel-shortcode.gallery-carousel-shortcode-id-b92313f65802c5f5cda12aeac6abd3bd .owl-nav a.owl-prev { top: 50%; 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} .gallery-carousel-shortcode.gallery-carousel-shortcode-id-b92313f65802c5f5cda12aeac6abd3bd.gallery-shortcode .gallery-zoom-ico { width: 44px; height: 44px; line-height: 44px; border-radius: 100px; margin: -22px 0 0 -22px; border-width: 0px; } .dt-icon-bg-on.gallery-carousel-shortcode.gallery-carousel-shortcode-id-b92313f65802c5f5cda12aeac6abd3bd.gallery-shortcode .gallery-zoom-ico { background: rgba(255,255,255,0.3); box-shadow: none; } .gallery-carousel-shortcode.gallery-carousel-shortcode-id-b92313f65802c5f5cda12aeac6abd3bd.gallery-shortcode .gallery-zoom-ico:before, .gallery-carousel-shortcode.gallery-carousel-shortcode-id-b92313f65802c5f5cda12aeac6abd3bd.gallery-shortcode .gallery-zoom-ico span { font-size: 32px; line-height: 44px; color: #ffffff; background: none; } </style><div class="owl-carousel gallery-carousel-shortcode gallery-shortcode dt-gallery-container dt-owl-carousel-call gallery-carousel-shortcode-id-b92313f65802c5f5cda12aeac6abd3bd meta-info-off bullets-small-dot-stroke reposition-arrows dt-icon-bg-off arrows-bg-off disable-arrows-hover-bg arrows-hover-bg-off hover-fade " data-scroll-mode="1" data-col-num="1" data-wide-col-num="1" data-laptop-col="1" data-h-tablet-columns-num="1" data-v-tablet-columns-num="1" data-phone-columns-num="1" data-col-gap="0" data-stage-padding="0" data-speed="600" data-autoplay="false" data-autoplay_speed="6000" data-arrows="true" data-bullet="false" data-next-icon="icon-ar-017-r" data-prev-icon="icon-ar-017-l" data-img-shadow-size="12px" data-img-shadow-spread="3px"><div data-post-id="7973" data-date="2023-12-19T10:13:40+01:00" data-name="Positive HER2 in malignant breast cancer detected with NaveniBright"><figure class="post"><a href="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-NaveniBright-1.jpg" class="rollover dt-pswp-item" data-large_image_width="2071" data-large_image_height="1536" data-dt-img-description="" title="Positive HER2 in malignant breast cancer detected with NaveniBright"><img decoding="async" class="preload-me aspect" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%202071%201536'%3E%3C/svg%3E" data-lazy-srcset="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-NaveniBright-1.jpg 2071w" style="--ratio: 2071 / 1536" data-lazy-sizes="(max-width: 2071px) 100vw, 2071px" alt="Positive HER2 in malignant breast cancer detected with NaveniBright" width="2071" height="1536" data-lazy-src="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-NaveniBright-1.jpg" /><noscript><img decoding="async" class="preload-me aspect" src="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-NaveniBright-1.jpg" srcset="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-NaveniBright-1.jpg 2071w" style="--ratio: 2071 / 1536" sizes="(max-width: 2071px) 100vw, 2071px" alt="Positive HER2 in malignant breast cancer detected with NaveniBright" width="2071" height="1536" /></noscript><span class="gallery-rollover"></span></a></figure></div><div data-post-id="7974" data-date="2023-12-19T10:18:46+01:00" data-name="Negative HER2 in breast tissue detected with NaveniBright"><figure class="post"><a href="https://navinci.se/wp-content/uploads/2023/12/Negative-HER2-in-breast-tissue-detected-with-NaveniBright.jpg" class="rollover dt-pswp-item" data-large_image_width="2071" data-large_image_height="1536" data-dt-img-description="" title="Negative HER2 in breast tissue detected with NaveniBright"><img decoding="async" class="preload-me aspect" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%202071%201536'%3E%3C/svg%3E" data-lazy-srcset="https://navinci.se/wp-content/uploads/2023/12/Negative-HER2-in-breast-tissue-detected-with-NaveniBright.jpg 2071w" style="--ratio: 2071 / 1536" data-lazy-sizes="(max-width: 2071px) 100vw, 2071px" alt="Negative HER2 in breast tissue detected with NaveniBright" width="2071" height="1536" data-lazy-src="https://navinci.se/wp-content/uploads/2023/12/Negative-HER2-in-breast-tissue-detected-with-NaveniBright.jpg" /><noscript><img decoding="async" class="preload-me aspect" src="https://navinci.se/wp-content/uploads/2023/12/Negative-HER2-in-breast-tissue-detected-with-NaveniBright.jpg" srcset="https://navinci.se/wp-content/uploads/2023/12/Negative-HER2-in-breast-tissue-detected-with-NaveniBright.jpg 2071w" style="--ratio: 2071 / 1536" sizes="(max-width: 2071px) 100vw, 2071px" alt="Negative HER2 in breast tissue detected with NaveniBright" width="2071" height="1536" /></noscript><span class="gallery-rollover"></span></a></figure></div></div> <div class="wpb_text_column wpb_content_element vc_custom_1702979156060" > <div class="wpb_wrapper"> <p style="font-size: 14px; line-height: 20px; text-align: center;"><em>In situ</em> proximity ligation assay detection of HER2 in breast tissue, image one shows positive staining in malignant tissue and image two negative staining in healthy tissue. Signals are visualised using NaveniBright HRP</p> </div> </div> </div></div></div></div><div class="vc_row-full-width vc_clearfix"></div><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1 vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-5 vc_hidden-md vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_right"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201035%20768'%3E%3C/svg%3E" width="1035" height="768" alt="Positive HER2 in malignant breast cancer detected with IHC" title="Positive HER2 in malignant breast cancer detected with IHC" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/positive-her2-in-malignant-breast-cancer-detected-with-ihc/" data-lazy-src="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-IHC-1035x768.jpg" /><noscript><img decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-IHC-1035x768.jpg" width="1035" height="768" alt="Positive HER2 in malignant breast cancer detected with IHC" title="Positive HER2 in malignant breast cancer detected with IHC" loading="lazy" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/positive-her2-in-malignant-breast-cancer-detected-with-ihc/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element vc_custom_1703239405939" > <div class="wpb_wrapper"> <p style="font-size: 14px; text-align: center; line-height: 20px;">IHC detection of HER2 in breast tissue, showing positive staining in malignant tissue, A using rabbit mAb and B using mouse mAb</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-5 vc_hidden-md vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_right"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201035%20768'%3E%3C/svg%3E" width="1035" height="768" alt="Negative HER2 in breast tissue detected with IHC, unspecific signals" title="Negative HER2 in breast tissue detected with IHC, unspecific signals" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/negative-her2-in-breast-tissue-detected-with-ihc-unspecific-signals/" data-lazy-src="https://navinci.se/wp-content/uploads/2023/12/Negative-HER2-in-breast-tissue-detected-with-IHC-unspecific-signals-1035x768.jpg" /><noscript><img decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/12/Negative-HER2-in-breast-tissue-detected-with-IHC-unspecific-signals-1035x768.jpg" width="1035" height="768" alt="Negative HER2 in breast tissue detected with IHC, unspecific signals" title="Negative HER2 in breast tissue detected with IHC, unspecific signals" loading="lazy" data-dt-location="https://navinci.se/applications/assay-database/detection-of-her2/negative-her2-in-breast-tissue-detected-with-ihc-unspecific-signals/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element vc_custom_1702979404541" > <div class="wpb_wrapper"> <p style="font-size: 14px; text-align: center; line-height: 20px;">IHC detection of HER2 in breast tissue, showing unspecific staining of HER2 given that the breast tissue is not expressing HER2</p> </div> </div> </div></div></div></div><div data-vc-full-width="true" data-vc-full-width-init="false" data-vc-stretch-content="true" class="vc_row wpb_row vc_row-fluid vc_row-no-padding"><div class="wpb_column vc_column_container vc_col-sm-12 vc_hidden-lg vc_col-xs-12"><div class="vc_column-inner"><div class="wpb_wrapper"><style type="text/css" data-type="the7_shortcodes-inline-css">.gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca .owl-nav a { width: 36px; height: 36px; border-radius: 500px; } .dt-arrow-border-on.gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca .owl-nav a:not(:hover):before { border-width: 0px; } .dt-arrow-hover-border-on.gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca .owl-nav a:hover:after { border-width: 0px; } .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca .owl-nav a.owl-prev { top: 50%; transform: translateY(calc(-50% + 0px)); left: -43px; } @media all and (-ms-high-contrast: none) { .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca .owl-nav a.owl-prev { transform: translateY(-50%); margin-top: 0px; } } .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca .owl-nav a.owl-prev i { padding: 0px 0px 0px 0px; } .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca .owl-nav a.owl-next { top: 50%; transform: translateY(calc(-50% + 0px)); right: -43px; } @media all and (-ms-high-contrast: none) { .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca .owl-nav a.owl-next { transform: translateY(-50%); margin-top: 0px; } } .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca .owl-nav a.owl-next i { padding: 0px 0px 0px 0px; 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margin-left: 0px; } } .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca .owl-dot { width: 10px; height: 10px; margin: 0 8px; } @media screen and (max-width: 778px) { .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca.hide-arrows .owl-nav a { display: none; } } @media screen and (max-width: 778px) { .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca.reposition-arrows .owl-nav .owl-prev { top: 50%; transform: translateY(calc(-50% + 0px)); left: 10px; } .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca.reposition-arrows .owl-nav .owl-next { top: 50%; transform: translateY(calc(-50% + 0px)); right: 10px; } } @media screen and (max-width: 778px) and all and (-ms-high-contrast: none) { .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca.reposition-arrows .owl-nav .owl-prev { transform: translateY(-50%); margin-top: 0px; } } @media screen and (max-width: 778px) and all and (-ms-high-contrast: none) { .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca.reposition-arrows .owl-nav .owl-next { transform: translateY(-50%); margin-top: 0px; } } .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca figure, .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca .rollover, .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca img, .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca .gallery-rollover { border-radius: 0px; } .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca.enable-bg-rollover .gallery-rollover { background: -webkit-linear-gradient(); background: linear-gradient(); } .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca.enable-img-shadow .owl-stage-outer { padding: 4px 0; } .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca.enable-bg-rollover.hover-scale figure .rollover:after { background: -webkit-linear-gradient(); background: linear-gradient(); } .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca.gallery-shortcode .gallery-zoom-ico { width: 44px; height: 44px; line-height: 44px; border-radius: 100px; margin: -22px 0 0 -22px; border-width: 0px; } .dt-icon-bg-on.gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca.gallery-shortcode .gallery-zoom-ico { background: rgba(255,255,255,0.3); box-shadow: none; } .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca.gallery-shortcode .gallery-zoom-ico:before, .gallery-carousel-shortcode.gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca.gallery-shortcode .gallery-zoom-ico span { font-size: 32px; line-height: 44px; color: #ffffff; background: none; } </style><div class="owl-carousel gallery-carousel-shortcode gallery-shortcode dt-gallery-container dt-owl-carousel-call gallery-carousel-shortcode-id-1fb5418de0736cb0eba1adb0b159e8ca meta-info-off bullets-small-dot-stroke reposition-arrows dt-icon-bg-off arrows-bg-off disable-arrows-hover-bg arrows-hover-bg-off hover-fade " data-scroll-mode="1" data-col-num="1" data-wide-col-num="1" data-laptop-col="1" data-h-tablet-columns-num="1" data-v-tablet-columns-num="1" data-phone-columns-num="1" data-col-gap="0" data-stage-padding="0" data-speed="600" data-autoplay="false" data-autoplay_speed="6000" data-arrows="true" data-bullet="false" data-next-icon="icon-ar-017-r" data-prev-icon="icon-ar-017-l" data-img-shadow-size="12px" data-img-shadow-spread="3px"><div data-post-id="7976" data-date="2023-12-19T10:47:10+01:00" data-name="Positive HER2 in malignant breast cancer detected with IHC"><figure class="post"><a href="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-IHC.jpg" class="rollover dt-pswp-item" data-large_image_width="2071" data-large_image_height="1536" data-dt-img-description="" title="Positive HER2 in malignant breast cancer detected with IHC"><img decoding="async" class="preload-me aspect" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%202071%201536'%3E%3C/svg%3E" data-lazy-srcset="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-IHC.jpg 2071w" style="--ratio: 2071 / 1536" data-lazy-sizes="(max-width: 2071px) 100vw, 2071px" alt="Positive HER2 in malignant breast cancer detected with IHC" width="2071" height="1536" data-lazy-src="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-IHC.jpg" /><noscript><img decoding="async" class="preload-me aspect" src="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-IHC.jpg" srcset="https://navinci.se/wp-content/uploads/2023/12/Positive-HER2-in-malignant-breast-cancer-detected-with-IHC.jpg 2071w" style="--ratio: 2071 / 1536" sizes="(max-width: 2071px) 100vw, 2071px" alt="Positive HER2 in malignant breast cancer detected with IHC" width="2071" height="1536" /></noscript><span class="gallery-rollover"></span></a></figure></div><div data-post-id="7977" data-date="2023-12-19T10:48:12+01:00" data-name="Negative HER2 in breast tissue detected with IHC, unspecific signals"><figure class="post"><a href="https://navinci.se/wp-content/uploads/2023/12/Negative-HER2-in-breast-tissue-detected-with-IHC-unspecific-signals.jpg" class="rollover dt-pswp-item" data-large_image_width="2071" data-large_image_height="1536" data-dt-img-description="" title="Negative HER2 in breast tissue detected with IHC, unspecific signals"><img decoding="async" class="preload-me aspect" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%202071%201536'%3E%3C/svg%3E" data-lazy-srcset="https://navinci.se/wp-content/uploads/2023/12/Negative-HER2-in-breast-tissue-detected-with-IHC-unspecific-signals.jpg 2071w" style="--ratio: 2071 / 1536" data-lazy-sizes="(max-width: 2071px) 100vw, 2071px" alt="Negative HER2 in breast tissue detected with IHC, unspecific signals" width="2071" height="1536" data-lazy-src="https://navinci.se/wp-content/uploads/2023/12/Negative-HER2-in-breast-tissue-detected-with-IHC-unspecific-signals.jpg" /><noscript><img decoding="async" class="preload-me aspect" src="https://navinci.se/wp-content/uploads/2023/12/Negative-HER2-in-breast-tissue-detected-with-IHC-unspecific-signals.jpg" srcset="https://navinci.se/wp-content/uploads/2023/12/Negative-HER2-in-breast-tissue-detected-with-IHC-unspecific-signals.jpg 2071w" style="--ratio: 2071 / 1536" sizes="(max-width: 2071px) 100vw, 2071px" alt="Negative HER2 in breast tissue detected with IHC, unspecific signals" width="2071" height="1536" /></noscript><span class="gallery-rollover"></span></a></figure></div></div> <div class="wpb_text_column wpb_content_element vc_custom_1703239425519" > <div class="wpb_wrapper"> <p style="font-size: 14px; line-height: 20px; text-align: center;">IHC detection of HER2 in breast tissue, image one shows positive staining in malignant tissue, A using rabbit mAb and B using mouse mAb. Image two shows unspecific staining of HER2 given that the breast tissue is not expressing HER2</p> </div> </div> </div></div></div></div><div class="vc_row-full-width vc_clearfix"></div><div data-vc-full-width="true" data-vc-full-width-init="false" data-vc-stretch-content="true" class="vc_row wpb_row vc_row-fluid vc_row-no-padding"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_separator wpb_content_element vc_separator_align_center vc_sep_width_100 vc_sep_pos_align_center vc_separator_no_text vc_sep_color_grey wpb_content_element wpb_content_element" ><span class="vc_sep_holder vc_sep_holder_l"><span class="vc_sep_line"></span></span><span class="vc_sep_holder vc_sep_holder_r"><span class="vc_sep_line"></span></span> </div></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div><section class="vc_section"><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 vc_hidden-md vc_hidden-sm vc_col-xs-12"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h2 style="color: #000000; font-size: 24px; line-height: 28px;">How to detect HER2 with precision</h2> <p style="font-size: 16px; line-height: 28px;">Use our flexible products NaveniBright HRP or NaveniFlex Tissue. For further information about HER2 monoclonal antibodies and protocols, please contact us using the form below.</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-5 vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-10 vc_hidden-lg vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h2 style="color: #000000; font-size: 24px; line-height: 28px;">How to detect HER2 with precision</h2> <p style="font-size: 16px; line-height: 28px;">Use our flexible products NaveniBright HRP or NaveniFlex Tissue. For further information about HER2 monoclonal antibodies and protocols, please contact us using the form below.</p> </div> </div> </div></div></div></div><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-4 vc_hidden-md vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_row wpb_row vc_inner vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-5"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20200%20300'%3E%3C/svg%3E" width="200" height="300" alt="Sebaceous Gland - MR - brighter" title="Sebaceous Gland - MR - brighter" data-dt-location="https://navinci.se/navenibrightfield-launch/sebaceous-gland-mr-brighter/" data-lazy-src="https://navinci.se/wp-content/uploads/2022/04/Sebaceous-Gland-MR-brighter-200x300.jpg" /><noscript><img decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2022/04/Sebaceous-Gland-MR-brighter-200x300.jpg" width="200" height="300" alt="Sebaceous Gland - MR - brighter" title="Sebaceous Gland - MR - brighter" loading="lazy" data-dt-location="https://navinci.se/navenibrightfield-launch/sebaceous-gland-mr-brighter/" /></noscript></div> </figure> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p style="font-size: 16px; line-height: 28px;"><strong>NaveniBright HRP</strong></p> <p style="font-size: 14px; line-height: 25px;">The assay is designed to be used with a mouse and a rabbit primary pair. Chromogenic readout with HRP substrate.</p> </div> </div> <div class="vc_btn3-container vc_btn3-inline" ><a class="vc_general vc_btn3 vc_btn3-size-md vc_btn3-shape-square vc_btn3-style-flat vc_btn3-color-warning" href="https://navinci.se/product/navenibright-hrp/" title="NaveniBright HRP">View product</a></div></div></div></div></div></div></div></div><div class="wpb_column vc_column_container vc_col-sm-4 vc_hidden-md vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_row wpb_row vc_inner vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-5"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20200%20300'%3E%3C/svg%3E" width="200" height="300" alt="NavenFlex Tissue MR_Atto Colon Beta-Catenin_E-Cadherin interaction" title="NavenFlex Tissue MR_Atto Colon Beta-Catenin_E-Cadherin interaction" data-dt-location="https://navinci.se/?attachment_id=6255" data-lazy-src="https://navinci.se/wp-content/uploads/2023/01/NA7A131-200x300.png" /><noscript><img decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/01/NA7A131-200x300.png" width="200" height="300" alt="NavenFlex Tissue MR_Atto Colon Beta-Catenin_E-Cadherin interaction" title="NavenFlex Tissue MR_Atto Colon Beta-Catenin_E-Cadherin interaction" loading="lazy" data-dt-location="https://navinci.se/?attachment_id=6255" /></noscript></div> </figure> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p style="font-size: 16px; line-height: 28px;"><strong>NaveniFlex Tissue</strong></p> <p style="font-size: 14px; line-height: 25px;">The assay is designed to be used with a mouse and rabbit primary antibody pair. Detection with Atto647N fluorophore is included.</p> </div> </div> <div class="vc_btn3-container vc_btn3-inline" ><a class="vc_general vc_btn3 vc_btn3-size-md vc_btn3-shape-square vc_btn3-style-flat vc_btn3-color-warning" href="https://navinci.se/product/naveniflex-tissue-mr-atto647n/" title="NaveniBright AP">View product</a></div></div></div></div></div></div></div></div><div class="wpb_column vc_column_container vc_col-sm-3"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div><div data-vc-full-width="true" data-vc-full-width-init="false" class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-6 vc_hidden-lg"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_row wpb_row vc_inner vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-6 vc_col-xs-6"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20175%20280'%3E%3C/svg%3E" width="175" height="280" alt="Sebaceous Gland - MR - brighter" title="Sebaceous Gland - MR - brighter" data-dt-location="https://navinci.se/navenibrightfield-launch/sebaceous-gland-mr-brighter/" data-lazy-src="https://navinci.se/wp-content/uploads/2022/04/Sebaceous-Gland-MR-brighter-175x280.jpg" /><noscript><img decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2022/04/Sebaceous-Gland-MR-brighter-175x280.jpg" width="175" height="280" alt="Sebaceous Gland - MR - brighter" title="Sebaceous Gland - MR - brighter" loading="lazy" data-dt-location="https://navinci.se/navenibrightfield-launch/sebaceous-gland-mr-brighter/" /></noscript></div> </figure> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 vc_col-xs-6"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p style="font-size: 16px; line-height: 28px;"><strong>NaveniBright HRP</strong></p> <p style="font-size: 16px; line-height: 28px;">The assay is designed to be used with a mouse and a rabbit primary pair. Chromogenic readout with HRP substrate.</p> </div> </div> <div class="vc_btn3-container vc_btn3-inline" ><a class="vc_general vc_btn3 vc_btn3-size-md vc_btn3-shape-square vc_btn3-style-flat vc_btn3-color-warning" href="https://navinci.se/product/navenibright-hrp/" title="NaveniBright HRP">View product</a></div></div></div></div></div></div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 vc_hidden-lg"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_row wpb_row vc_inner vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-6 vc_col-xs-6"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20175%20280'%3E%3C/svg%3E" width="175" height="280" alt="NavenFlex Tissue MR_Atto Colon Beta-Catenin_E-Cadherin interaction" title="NavenFlex Tissue MR_Atto Colon Beta-Catenin_E-Cadherin interaction" data-dt-location="https://navinci.se/?attachment_id=6255" data-lazy-src="https://navinci.se/wp-content/uploads/2023/01/NA7A131-175x280.png" /><noscript><img decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/01/NA7A131-175x280.png" width="175" height="280" alt="NavenFlex Tissue MR_Atto Colon Beta-Catenin_E-Cadherin interaction" title="NavenFlex Tissue MR_Atto Colon Beta-Catenin_E-Cadherin interaction" loading="lazy" data-dt-location="https://navinci.se/?attachment_id=6255" /></noscript></div> </figure> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 vc_col-xs-6"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p style="font-size: 16px; line-height: 28px;"><strong>NaveniFlex Tissue</strong></p> <p style="font-size: 16px; line-height: 28px;">The assay is designed to be used with a mouse and rabbit primary antibody pair. Detection with Atto647N fluorophore is included.</p> </div> </div> <div class="vc_btn3-container vc_btn3-inline" ><a class="vc_general vc_btn3 vc_btn3-size-md vc_btn3-shape-square vc_btn3-style-flat vc_btn3-color-warning" href="https://navinci.se/product/naveniflex-tissue-mr-atto647n/" title="NaveniBright AP">View product</a></div></div></div></div></div></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div></section><section class="vc_section"><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-11"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_raw_code wpb_raw_html wpb_content_element" > <div class="wpb_wrapper"> <iframe src="https://pages.upsales.com/15860u50a5bfa43ee341219f047c443861acce-frame"width="380"height="880"style="border:0"></iframe> </div> </div> </div></div></div></div><div data-vc-full-width="true" data-vc-full-width-init="false" data-vc-stretch-content="true" class="vc_row wpb_row vc_row-fluid vc_row-no-padding"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_separator wpb_content_element vc_separator_align_center vc_sep_width_100 vc_sep_pos_align_center vc_separator_no_text vc_sep_color_grey wpb_content_element wpb_content_element" ><span class="vc_sep_holder vc_sep_holder_l"><span class="vc_sep_line"></span></span><span class="vc_sep_holder vc_sep_holder_r"><span class="vc_sep_line"></span></span> </div></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div></section><section class="vc_section"><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-10"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h2 style="color: #000000; font-size: 24px; line-height: 28px;">References</h2> <ol> <li style="font-size: 13px; line-height: 18px;">Olayioye, M. A., Neve, R. M., Lane, H. A., & Hynes, N. E. (2000). The ErbB signaling network: receptor heterodimerization in development and cancer. <i>The EMBO journal</i>, <i>19</i>(13), 3159–3167. <span class="identifier doi"><span class="id-label">DOI: </span><a class="id-link" href="https://doi.org/10.1093/emboj/19.13.3159" target="_blank" rel="noopener" data-ga-category="full_text" data-ga-action="DOI">10.1093/emboj/19.13.3159</a></span></li> <li style="font-size: 13px; line-height: 18px;">Roskoski R., Jr (2019). Small molecule inhibitors targeting the EGFR/ErbB family of protein-tyrosine kinases in human cancers. <i>Pharmacological research</i>, <i>139</i>, 395–411. <span class="identifier doi"><span class="id-label">DOI: </span><a class="id-link" href="https://doi.org/10.1016/j.phrs.2018.11.014" target="_blank" rel="noopener" data-ga-category="full_text" data-ga-action="DOI">10.1016/j.phrs.2018.11.014</a></span></li> <li style="font-size: 13px; line-height: 18px;">Olayioye M. A. (2001). 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DOI: <a href="https://doi.org/10.1200/JCO.2013.50.9984" target="_blank" rel="noopener">10.1200/JCO.2013.50.9984</a></li> </ol> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div></section> </div> </div> </div> </div> </div>  <footer data-rocket-location-hash="0c3e3b6b1edc6c32a8efb711e964d337" id="footer" class="footer solid-bg"> <div data-rocket-location-hash="3e60cd8253a1ade3decd617a69f1a5d7" class="wf-wrap"> <div class="wf-container-footer"> <div class="wf-container"> <section id="custom_html-2" class="widget_text widget widget_custom_html wf-cell wf-1-2"><div class="widget-title">Contact us</div><div class="textwidget custom-html-widget"><p>Email: <a href="mailto:contact@navinci.se">contact@navinci.se</a></p></div></section><section id="nav_menu-2" class="widget widget_nav_menu wf-cell wf-1-2"><div class="widget-title">Menu</div><div class="menu-footern-container"><ul 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