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Gene Editing Toolkit

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Understand Gene Editing Experiments. 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class="navbar_item__jtENX"><a href="/solutions/gene-editing-toolkit" class="hover-border">Gene Editing Toolkit</a></div></div><div class="navbar_subNavbarCol__ES8j1"><div class="navbar_item__jtENX"><p class="p-xs color-xLight">Providers</p></div><div class="navbar_item__jtENX"><a href="/solutions/ngs-solutions-providers" class="hover-border">NGS Solution Providers</a></div></div></div></div></div></nav><div class="content"><main class="subPage_main___aCKT"><div class="subPage_heroContainer__C4Thz"><div class="container_container__7U8A5"><div class="subPage_hero__3ifPE"><div class="subPage_heroContent__6tnnS"><h1 class="h2">Gene Editing Toolkit</h1><p class="p-lg">Design CRISPR guides. Understand Gene Editing Experiments. Analyze Genome-Scale Screening Data.</p><div class="subPage_buttonContainer___xiv_"><div><div class="requestDemoForm_inlineForm__WV3Xi"><input type="email" autoComplete="email" placeholder="Enter your work email…" value=""/><button type="button" class="bold button_md__WVu1z button_normal__dQOO7 button_btn__DjQft" rel="noopener"><span class="button_glow__U5paJ" style="left:0px;top:0px"></span><span class="button_btnContent__oxNmH">Free Trial<!-- --> <div class="button_arrow__2z32B"><svg viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg" class="icon"><g style="transform:rotate(0deg);transform-origin:center"><path d="M5 12H19" stroke="currentcolor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round"></path><path d="M12 5L19 12L12 19" stroke="currentcolor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round"></path></g></svg></div></span></button></div></div></div></div></div></div></div><div class="container_container__7U8A5 subPage_section__oSAPp"><hr class="subPage_spaceDivider__X0obF subPage_divider__bcdjq"/><div class="subPage_twoColSection__9IX_2"><div><p class="p-md">Overview</p></div><div><div class="subPage_textBlock__k_kL6"><h2 class="p-xl regular color-medium">Modular data infrastructure to engineer gene editing proteins and screen the genome.</h2></div><div class="subPage_imageSectionContainer__lQ_fV"><video preload="none" poster="/_next/static/media/crispress_plots.fec50514.png" placeholder="/_next/static/media/crispress_plots.fec50514.png" loop="" muted="" playsInline="" class="subPage_badVideo__2Ye0v"><source src="/_next/static/videos/crispress_plots-5f263af60c3c13fe21297fdee22279ed.mp4" type="video/mp4"/></video></div></div></div></div><div class="container_container__7U8A5 subPage_sectionbottom__kUALZ"><hr class="subPage_spaceDivider__X0obF subPage_divider__bcdjq"/><div class="subPage_twoColSection__9IX_2"><div><p class="p-md">Answer Biological Questions</p></div><div><ul class="list list-no-bullet subPage_benefitsList__NBlvS"><li class="p-s text-block"><div class="featureItem_container__CMU5e subPage_alignCenter__7jx3K" role="listitem"><div class="featureItem_iconContainer__SHHQN"><!--$!--><template data-dgst="DYNAMIC_SERVER_USAGE"></template><!--/$--></div><div class="featureItem_textContainer__0ZABB"><p class="p-lg">Search for potential off-target sites of RNA-guided endonucleases</p></div></div></li><hr class="subPage_divider__bcdjq"/><li class="p-s text-block"><div class="featureItem_container__CMU5e subPage_alignCenter__7jx3K" role="listitem"><div class="featureItem_iconContainer__SHHQN"><!--$!--><template data-dgst="DYNAMIC_SERVER_USAGE"></template><!--/$--></div><div class="featureItem_textContainer__0ZABB"><p class="p-lg">Quantify insertions, mutations and deletions from genome editing proteins</p></div></div></li><hr class="subPage_divider__bcdjq"/><li class="p-s text-block"><div class="featureItem_container__CMU5e subPage_alignCenter__7jx3K" role="listitem"><div class="featureItem_iconContainer__SHHQN"><!--$!--><template data-dgst="DYNAMIC_SERVER_USAGE"></template><!--/$--></div><div class="featureItem_textContainer__0ZABB"><p class="p-lg">Identify important genes from CRISPR-Cas9 knockout screens</p></div></div></li></ul></div></div></div><div class="container_container__7U8A5 subPage_sectionbottom__kUALZ"><hr class="subPage_spaceDivider__X0obF subPage_divider__bcdjq"/><div class="subPage_twoColSection__9IX_2"><div><p class="p-s">Join leading biopharma companies who engineer genomes on Latch</p></div><div><div class="subPage_bigLogosRow__dC_B5"><img alt="Arena Logo" loading="lazy" width="146" height="103.33333333333333" decoding="async" data-nimg="1" style="color:transparent" src="/_next/static/media/arena.a5b9764e.svg"/><img alt="Elsie GSK Logo" loading="lazy" width="212.66666666666666" height="39.333333333333336" decoding="async" data-nimg="1" style="color:transparent" src="/_next/static/media/elsie-gsk.39d89a11.svg"/><img alt="Broken String Logo" loading="lazy" width="210.66666666666666" height="72.66666666666667" decoding="async" data-nimg="1" style="color:transparent" src="/_next/static/media/broken-string.b141b8c9.svg"/></div></div></div></div><div class="container_container__7U8A5 subPage_benefitsCentered__P5ATt"><div class="featureItem_container__CMU5e subPage_alignCenter__7jx3K" role="listitem"><div class="featureItem_iconContainer__SHHQN"><!--$!--><template data-dgst="DYNAMIC_SERVER_USAGE"></template><!--/$--></div><div class="featureItem_textContainer__0ZABB"><p class="p-lg">Plug n play modular components with your existing infrastructure</p></div></div><div class="featureItem_container__CMU5e subPage_alignCenter__7jx3K" role="listitem"><div class="featureItem_iconContainer__SHHQN"><!--$!--><template data-dgst="DYNAMIC_SERVER_USAGE"></template><!--/$--></div><div class="featureItem_textContainer__0ZABB"><p class="p-lg">Generate publication quality plots with AI in seconds</p></div></div></div><div class="subPage_diffSection__ejLdp"><div class="container_container__7U8A5 subPage_section__oSAPp"><div class="subPage_timeLineContainer__C1rwY"><div class="subPage_timeLine__a8rf4"></div><div class="subPage_body__irQyX subPage_timeLineHeader__ibWG2"><p class="p-lg">Experimental Flow</p></div></div><div class="subPage_timeLineContainer__C1rwY"><div class="subPage_timeLine__a8rf4"><div class="subPage_number__XT_3b subPage_step2__d5S3E"><svg viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg" class="subPage_icon__hkEMr"><path d="M5.00028 16.0001C5.00027 15.4479 5.44798 15.0001 6.00027 15.0001H6.01027C6.56255 15.0001 7.01027 15.4478 7.01028 16.0001C7.01029 16.5524 6.56259 17.0001 6.0103 17.0001H6.0003C5.44802 17.0001 5.00029 16.5524 5.00028 16.0001Z" fill="currentcolor"></path><path d="M10.0003 15.0001C9.44798 15.0001 9.00027 15.4478 9.00028 16.0001C9.00029 16.5524 9.44802 17.0001 10.0003 17.0001H10.0103C10.5626 17 11.0103 16.5523 11.0103 16C11.0103 15.4478 10.5626 15 10.0103 15.0001H10.0003Z" fill="currentcolor"></path><path fill-rule="evenodd" clip-rule="evenodd" d="M16.7601 2.99994L7.24006 3.0001C6.68193 3.00041 6.13443 3.15641 5.6601 3.45055C5.18624 3.74441 4.80366 4.16451 4.55528 4.66369L4.55456 4.66515L1.11504 11.5345C1.04172 11.6736 1.00021 11.8321 1.00021 12.0002L1.00032 18.0002C1.00033 18.7959 1.31642 19.5589 1.87903 20.1215C2.44165 20.6841 3.20472 21.0002 4.00037 21.0002L20.0004 20.9999C20.796 20.9999 21.5591 20.6838 22.1217 20.1212C22.6843 19.5585 23.0003 18.7955 23.0003 17.9998L23.0002 11.9998C23.0002 11.9871 23 11.9744 22.9995 11.9617C22.9937 11.8077 22.9531 11.6626 22.8854 11.5341L19.4456 4.66489L19.445 4.66357C19.1966 4.16434 18.8139 3.7442 18.34 3.45033C17.8657 3.1562 17.3182 3.00023 16.7601 2.99994ZM20.3811 10.9999L17.6559 5.55766L17.6546 5.55492C17.5718 5.38832 17.4442 5.24811 17.286 5.15007C17.128 5.05206 16.9457 5.00007 16.7598 4.99994L7.24043 5.0001C7.05446 5.00024 6.8722 5.05224 6.71415 5.15025C6.55604 5.2483 6.42842 5.38851 6.34563 5.55512L5.45009 5.11014L6.34427 5.55785L3.61928 11.0002L20.3811 10.9999ZM3.00023 13.0002L3.00032 18.0002C3.00032 18.2654 3.10568 18.5197 3.29322 18.7073C3.48076 18.8948 3.73512 19.0002 4.00034 19.0002L20.0003 18.9999C20.2656 18.9999 20.5199 18.8945 20.7074 18.707C20.895 18.5194 21.0003 18.2651 21.0003 17.9999L21.0002 12.9999L3.00023 13.0002Z" fill="currentcolor"></path></svg></div><div class="subPage_line__zNPwu"></div></div><div class="subPage_body__irQyX"><div class="subPage_textBlock__k_kL6 text-block"><h2 class="h5">Genome Scale gRNA Design with GPUs</h2><p class="p-md">Scan the entire genome with accelerated hardware using Cas-OFFinder</p></div><div class="subPage_imageRow____XAk"><img alt="List of data within Latch" loading="lazy" width="4632" height="3776" decoding="async" data-nimg="1" class="subPage_badImage__ss8Ji" style="color:transparent" srcSet="/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fcas-offinder.bfea4bd4.png&amp;w=3840&amp;q=75 1x" src="/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fcas-offinder.bfea4bd4.png&amp;w=3840&amp;q=75"/></div></div></div><div class="subPage_timeLineContainer__C1rwY"><div class="subPage_timeLine__a8rf4"><div class="subPage_number__XT_3b subPage_step2__d5S3E"><svg viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg" class="subPage_icon__hkEMr"><path fill-rule="evenodd" clip-rule="evenodd" d="M15.7253 5.03849C16.2563 4.88677 16.8098 5.19426 16.9615 5.72529L20.9615 19.7253C21.1133 20.2563 20.8058 20.8098 20.2747 20.9615C19.7437 21.1133 19.1902 20.8058 19.0385 20.2747L15.0385 6.27473C14.8868 5.7437 15.1943 5.19021 15.7253 5.03849Z" fill="currentcolor"></path><path fill-rule="evenodd" clip-rule="evenodd" d="M12 5C12.5523 5 13 5.44772 13 6V20C13 20.5523 12.5523 21 12 21C11.4477 21 11 20.5523 11 20V6C11 5.44772 11.4477 5 12 5Z" fill="currentcolor"></path><path fill-rule="evenodd" clip-rule="evenodd" d="M8 7C8.55228 7 9 7.44772 9 8V20C9 20.5523 8.55228 21 8 21C7.44772 21 7 20.5523 7 20V8C7 7.44772 7.44772 7 8 7Z" fill="currentcolor"></path><path fill-rule="evenodd" clip-rule="evenodd" d="M4 3C4.55228 3 5 3.44772 5 4V20C5 20.5523 4.55228 21 4 21C3.44772 21 3 20.5523 3 20V4C3 3.44772 3.44772 3 4 3Z" fill="currentcolor"></path></svg></div><div class="subPage_line__zNPwu"></div></div><div class="subPage_body__irQyX"><div class="subPage_textBlock__k_kL6 text-block"><h2 class="h5">Explore Off-Target Statistics with AI-enabled Plots</h2><p class="p-md">Summarize information about mismatches and off-target locations with custom visualizations accessible to bench scientists</p></div><div class="subPage_imageRow____XAk"><video preload="none" poster="/_next/static/media/off-target-plots.761d7380.png" placeholder="/_next/static/media/off-target-plots.761d7380.png" loop="" muted="" playsInline="" class="subPage_badVideo__2Ye0v"><source src="/_next/static/videos/off-target-plots-669aa80d50dec743fe12750410be8e75.mp4"/></video></div></div></div><div class="subPage_timeLineContainer__C1rwY"><div class="subPage_timeLine__a8rf4"><div class="subPage_number__XT_3b subPage_step2__d5S3E"><svg viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg" class="subPage_icon__hkEMr"><path fill-rule="evenodd" clip-rule="evenodd" d="M3 2C3.55228 2 4 2.44772 4 3V20H21C21.5523 20 22 20.4477 22 21C22 21.5523 21.5523 22 21 22H3C2.44772 22 2 21.5523 2 21V3C2 2.44772 2.44772 2 3 2ZM6 11C6 9.89543 6.89543 9 8 9H10C11.1046 9 12 9.89543 12 11V16C12 17.1046 11.1046 18 10 18H8C6.89543 18 6 17.1046 6 16V11ZM10 11H8V16H10V11ZM16 4C14.8954 4 14 4.89543 14 6V16C14 17.1046 14.8954 18 16 18H18C19.1046 18 20 17.1046 20 16V6C20 4.89543 19.1046 4 18 4H16ZM16 6H18V16H16V6Z" fill="currentcolor"></path></svg></div><div class="subPage_line__zNPwu"></div></div><div class="subPage_body__irQyX"><div class="subPage_textBlock__k_kL6 text-block"><h2 class="h5 luminescent-text">Validate Editing Behavior of Single Guides with CRISPResso2</h2></div><div class="subPage_textBlock__k_kL6 text-block"><p class="p-md">Expose CRISPResso2 to biologists with a graphical interface</p></div><div class="subPage_imageRow____XAk"><img alt="" loading="lazy" width="1200" height="853" decoding="async" data-nimg="1" class="subPage_image__8VfBu" style="color:transparent" srcSet="/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fcrispresso-params.53b98708.png&amp;w=1200&amp;q=75 1x, /_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fcrispresso-params.53b98708.png&amp;w=3840&amp;q=75 2x" src="/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fcrispresso-params.53b98708.png&amp;w=3840&amp;q=75"/></div><div class="subPage_textBlock__k_kL6 text-block"><p class="p-md">Display the full suite of parameters for different types of editors and experiment designs.</p></div><div class="subPage_fakeBentoGrid__m9H1u"><div class="subPage_fakeBentoBox__w0lIc"><p class="p-md color-medium">Mount S3 / GCP buckets, integrate with Illumina Basespace, drag and drop from laptops, deploy custom upload scripts from local servers</p><img alt="List of data within Latch" loading="lazy" width="844" height="730" decoding="async" data-nimg="1" class="subPage_image__8VfBu" style="color:transparent;position:absolute;top:172px;right:10%;border-top-right-radius:var(--bento-image-radius)" srcSet="/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fdata-ingest-options.4feb74ff.png&amp;w=1080&amp;q=75 1x, /_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fdata-ingest-options.4feb74ff.png&amp;w=1920&amp;q=75 2x" src="/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fdata-ingest-options.4feb74ff.png&amp;w=1920&amp;q=75"/></div><div class="subPage_fakeBentoBox__w0lIc"><p class="p-md color-medium">Access the familiar CRISPResso2 HTML report to inspect editing behavior and visualize the distribution of alleles</p><img alt="List of data within Latch" loading="lazy" width="700" height="373" decoding="async" data-nimg="1" class="subPage_image__8VfBu" style="color:transparent;position:absolute;top:165px;right:15%;max-width:95%;border-top-right-radius:var(--bento-image-radius)" srcSet="/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fcrispresso-report.84685561.png&amp;w=750&amp;q=75 1x, /_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fcrispresso-report.84685561.png&amp;w=1920&amp;q=75 2x" src="/_next/image?url=%2F_next%2Fstatic%2Fmedia%2Fcrispresso-report.84685561.png&amp;w=1920&amp;q=75"/></div></div></div></div><div class="subPage_timeLineContainer__C1rwY"><div class="subPage_timeLine__a8rf4"><div class="subPage_number__XT_3b subPage_step2__d5S3E"><svg viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg" class="subPage_icon__hkEMr"><path fill-rule="evenodd" clip-rule="evenodd" d="M3 2C3.55228 2 4 2.44772 4 3V20H21C21.5523 20 22 20.4477 22 21C22 21.5523 21.5523 22 21 22H3C2.44772 22 2 21.5523 2 21V3C2 2.44772 2.44772 2 3 2ZM6 11C6 9.89543 6.89543 9 8 9H10C11.1046 9 12 9.89543 12 11V16C12 17.1046 11.1046 18 10 18H8C6.89543 18 6 17.1046 6 16V11ZM10 11H8V16H10V11ZM16 4C14.8954 4 14 4.89543 14 6V16C14 17.1046 14.8954 18 16 18H18C19.1046 18 20 17.1046 20 16V6C20 4.89543 19.1046 4 18 4H16ZM16 6H18V16H16V6Z" fill="currentcolor"></path></svg></div><div class="subPage_line__zNPwu"></div></div><div class="subPage_body__irQyX"><div class="subPage_textBlock__k_kL6 text-block"><h2 class="h5 luminescent-text">Explore CRISPResso2 Results with AI-enabled Dashboards</h2><p class="p-md">Adapt gold-standard academic tools to the specific scientific needs of your teams. Programmable dashboards + rich graphical controls for scientists</p></div><div class="subPage_imageRow____XAk"><video preload="none" poster="/_next/static/media/crispress_plots.fec50514.png" placeholder="/_next/static/media/crispress_plots.fec50514.png" loop="" muted="" playsInline="" class="subPage_badVideo__2Ye0v"><source src="/_next/static/videos/crispress_plots-5f263af60c3c13fe21297fdee22279ed.mp4"/></video></div></div></div><div class="subPage_timeLineContainer__C1rwY"><div class="subPage_timeLine__a8rf4"><div class="subPage_number__XT_3b subPage_step2__d5S3E"><svg viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg" class="subPage_icon__hkEMr"><path fill-rule="evenodd" clip-rule="evenodd" d="M10.937 1.29117C11.2586 1.10116 11.6253 1.00006 12 1.00005C12.3748 1.00005 12.7415 1.10113 13.0631 1.29113L13.0653 1.29246L16.9543 3.57285C17.2759 3.7634 17.5399 4.03548 17.7222 4.35926C17.9045 4.68288 17.9997 5.04808 18.0001 5.41848L18.0002 9.98042C18.0001 10.068 17.9947 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10.0593C8.03303 10.0813 8.04899 10.0966 8.06457 10.106L8.06548 10.1066L11.9544 12.3869C11.9701 12.3962 11.9858 12.4001 12.0002 12.4001C12.0147 12.4001 12.0304 12.3962 12.0461 12.387L12.0499 12.3847L15.9349 10.1064L15.9358 10.1059C15.9514 10.0964 15.9674 10.0812 15.9798 10.0591C15.9924 10.0366 16.0001 10.0092 16.0002 9.97988L16.0001 5.42051C16 5.39117 15.9923 5.36333 15.9797 5.34083C15.9673 5.31882 15.9513 5.30354 15.9357 5.2941L15.9348 5.29355L12.0459 3.01316C12.0302 3.00387 12.0145 3.00005 12.0001 3.00005Z" fill="currentcolor"></path></svg></div><div class="subPage_line__zNPwu subPage_short__Bwrc7"></div></div><div class="subPage_body__irQyX"><div class="subPage_textBlock__k_kL6 text-block"><h2 class="h5 luminescent-text">Analyze Genome Wide CRISPR Screens</h2><p class="p-s">Identify important genes from large scale perturbation experiments with MAGeCK.</p></div><div class="subPage_imageRow____XAk"><video preload="none" poster="/_next/static/media/mageck_execution.899710be.png" 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