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id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Ildiko Horvath</h3></div><div class="js-work-strip profile--work_container" data-work-id="29005857"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/29005857/Unbiased_clustering_of_severe_asthma_patients_based_on_exhaled_breath_profiles"><img alt="Research paper thumbnail of Unbiased clustering of severe asthma patients based on exhaled breath profiles" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/29005857/Unbiased_clustering_of_severe_asthma_patients_based_on_exhaled_breath_profiles">Unbiased clustering of severe asthma patients based on exhaled breath profiles</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AntonVink">Anton Vink</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://sote.academia.edu/HorvathIldiko">Ildiko Horvath</a></span></div><div class="wp-workCard_item"><span>European Respiratory Journal</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span 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data-click-track="profile-work-strip-title" href="https://www.academia.edu/21369396/Unbiased_clustering_of_severe_asthma_patients_based_on_exhaled_breath_profiles">Unbiased clustering of severe asthma patients based on exhaled breath profiles</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/HugoKnobel">Hugo Knobel</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/HansWeda">Hans Weda</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://sote.academia.edu/HorvathIldiko">Ildiko Horvath</a></span></div><div class="wp-workCard_item"><span>European Respiratory Journal</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" 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main challenges in ocology. Our therapeutic possibilities are expanded, but the inoperable non small-cellular lung cancer patients&#39; changes of survival are inconspicuous (5year survival-regardless of treatment - is around 14%). The rapid development of molecular genetics, the automatization of drug-synthesis put down the basis of targeted molecular tumor therapy. In our paper we present two cases from our database, in which using 3rd line gefitinib as chemotherapeutic method we achieved important radiological and clinical regression. 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However, the potential harmful effects of e-cigarettes on the human body have not been fully investigated and the related health risks have not been listed. The English full text version of this article is available at SpringerLink (under “Supplemental”). Zusammenfassung Elektronische Nikotinabgabesysteme, auch E-Zigaretten genannt, werden als alternative Methode zur Versorgung mit Nikotin beworben und verkauft, die hilfreich sein soll, wenn man mit dem Rauchen aufhören will. Allerdings sind bisher die möglichen schädlichen Wirkungen von E-Zigaretten auf den menschlichen Körper nicht vollständig untersucht und die gesundheitsbezogenen Risiken nicht aufgeführt worden. 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However, the potential harmful effects of e-cigarettes on the human body have not been fully investigated and the related health risks have not been listed. The English full text version of this article is available at SpringerLink (under “Supplemental”). Zusammenfassung Elektronische Nikotinabgabesysteme, auch E-Zigaretten genannt, werden als alternative Methode zur Versorgung mit Nikotin beworben und verkauft, die hilfreich sein soll, wenn man mit dem Rauchen aufhören will. Allerdings sind bisher die möglichen schädlichen Wirkungen von E-Zigaretten auf den menschlichen Körper nicht vollständig untersucht und die gesundheitsbezogenen Risiken nicht aufgeführt worden. 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Allerdings sind bisher die möglichen schädlichen Wirkungen von E-Zigaretten auf den menschlichen Körper nicht vollständig untersucht und die gesundheitsbezogenen Risiken nicht aufgeführt worden. Die englische Volltextversion dieses Beitrags ist über SpringerLink (unter „Supplemental“) verfügbar.","internal_url":"https://www.academia.edu/20849293/Zu_den_akuten_pulmonalen_Wirkungen_bei_Verwendung_einer_E_Zigarette","translated_internal_url":"","created_at":"2016-01-26T13:29:53.148-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42005307,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Zu_den_akuten_pulmonalen_Wirkungen_bei_Verwendung_einer_E_Zigarette","translated_slug":"","page_count":null,"language":"de","content_type":"Work","owner":{"id":42005307,"first_name":"Ildiko","middle_initials":"","last_name":"Horvath","page_name":"HorvathIldiko","domain_name":"sote","created_at":"2016-01-24T08:22:24.674-08:00","display_name":"Ildiko Horvath","url":"https://sote.academia.edu/HorvathIldiko"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20849292"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20849292/Exhaled_carbon_monoxide_in_airway_diseases_from_research_findings_to_clinical_relevance"><img alt="Research paper thumbnail of Exhaled carbon monoxide in airway diseases: from research findings to clinical relevance" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849292/Exhaled_carbon_monoxide_in_airway_diseases_from_research_findings_to_clinical_relevance">Exhaled carbon monoxide in airway diseases: from research findings to clinical relevance</a></div><div class="wp-workCard_item"><span>Journal of Breath Research</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Breath tests have gained increasing interest in recent years mainly driven by the unmet clinical ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Breath tests have gained increasing interest in recent years mainly driven by the unmet clinical need to monitor airway diseases and to obtain information of unravelled aspects of respiratory disorders. Carbon monoxide is present in the exhaled breath and has been suggested to reflect ongoing oxidative stress, even if there are some confounding factors limiting its clinical usefulness. Increased concentration of exhaled carbon monoxide has been demonstrated in different acute and chronic airway diseases including allergic rhinitis, asthma, bronchiectasis, and post transplant bronchiolitis obliterans syndrome. Although exhaled carbon monoxide might not prove as a clinically useful biomarker of airway diseases, its measurement has helped to understand the place of heme oxygenase activity in allergic and non-allergic airway diseases. The scope of this review is the exciting field of exhaled carbon monoxide in airway diseases.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849292"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849292"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20849292; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20849292]").text(description); $(".js-view-count[data-work-id=20849292]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20849292; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20849292']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20849292, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20849292]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20849292,"title":"Exhaled carbon monoxide in airway diseases: from research findings to clinical relevance","translated_title":"","metadata":{"abstract":"Breath tests have gained increasing interest in recent years mainly driven by the unmet clinical need to monitor airway diseases and to obtain information of unravelled aspects of respiratory disorders. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20849289"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20849289/Effects_of_Blockade_of_the_Renin_Angiotensin_and_Endothelin_Systems_on_Experimental_Bronchiolitis_Obliterans"><img alt="Research paper thumbnail of Effects of Blockade of the Renin–Angiotensin and Endothelin Systems on Experimental Bronchiolitis Obliterans" class="work-thumbnail" src="https://attachments.academia-assets.com/41920127/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849289/Effects_of_Blockade_of_the_Renin_Angiotensin_and_Endothelin_Systems_on_Experimental_Bronchiolitis_Obliterans">Effects of Blockade of the Renin–Angiotensin and Endothelin Systems on Experimental Bronchiolitis Obliterans</a></div><div class="wp-workCard_item"><span>The Journal of Heart and Lung Transplantation</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Blockade of the renin-angiotensin and the endothelin (ET) systems ameliorates fibrous airway obli...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Blockade of the renin-angiotensin and the endothelin (ET) systems ameliorates fibrous airway obliteration in rat tracheal allografts. The aim of this study was to test which of these pharmacologic interventions attenuates the process more effectively, and whether combination therapy confers additional benefit. Rat tracheas were heterotopically transplanted from Brown-Norway donors into Lewis recipients. Recipients received the dual endothelin-1 (ET-1) receptor blocker, bosentan (100 mg/kg), the angiotensin-converting enzyme (ACE) inhibitor, ramipril (5 mg/kg), bosentan plus ramipril (doses as just noted) or vehicle. Grafts were harvested at Days 7 and 21 for morphometric studies and molecular analysis by real-time polymerase chain reaction (PCR). At Day 21, bosentan and ramipril treatment reduced the percentage of luminal occlusion compared with vehicle to a similar extent. In animals that received the combined treatment, luminal obliteration was further reduced compared with the respective monotherapies. Furthermore, rats treated with bosentan plus ramipril showed a lower percent of epithelial necrosis. The beneficial effects of bosentan and ramipril, alone or in combination, were associated with reduced mRNA levels of transforming growth factor (TGF)-beta1 and platelet-derived growth factor (PDGF)-A in the tracheal allografts. Our data suggest that ET receptor blockade prevents fibrous airway obliteration to a similar extent as ACE inhibition in this model. Interruption of both pathways provides superior graft protection as compared with single-system blockade.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="912403a98b1f1503638b1f4385fde33f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41920127,"asset_id":20849289,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41920127/download_file?st=MTczMjQyMzc4NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849289"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849289"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20849289; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20849289]").text(description); $(".js-view-count[data-work-id=20849289]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20849289; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20849289']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20849289, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "912403a98b1f1503638b1f4385fde33f" } } $('.js-work-strip[data-work-id=20849289]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20849289,"title":"Effects of Blockade of the Renin–Angiotensin and Endothelin Systems on Experimental Bronchiolitis Obliterans","translated_title":"","metadata":{"abstract":"Blockade of the renin-angiotensin and the endothelin (ET) systems ameliorates fibrous airway obliteration in rat tracheal allografts. The aim of this study was to test which of these pharmacologic interventions attenuates the process more effectively, and whether combination therapy confers additional benefit. Rat tracheas were heterotopically transplanted from Brown-Norway donors into Lewis recipients. Recipients received the dual endothelin-1 (ET-1) receptor blocker, bosentan (100 mg/kg), the angiotensin-converting enzyme (ACE) inhibitor, ramipril (5 mg/kg), bosentan plus ramipril (doses as just noted) or vehicle. Grafts were harvested at Days 7 and 21 for morphometric studies and molecular analysis by real-time polymerase chain reaction (PCR). At Day 21, bosentan and ramipril treatment reduced the percentage of luminal occlusion compared with vehicle to a similar extent. In animals that received the combined treatment, luminal obliteration was further reduced compared with the respective monotherapies. Furthermore, rats treated with bosentan plus ramipril showed a lower percent of epithelial necrosis. The beneficial effects of bosentan and ramipril, alone or in combination, were associated with reduced mRNA levels of transforming growth factor (TGF)-beta1 and platelet-derived growth factor (PDGF)-A in the tracheal allografts. Our data suggest that ET receptor blockade prevents fibrous airway obliteration to a similar extent as ACE inhibition in this model. Interruption of both pathways provides superior graft protection as compared with single-system blockade.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"The Journal of Heart and Lung Transplantation"},"translated_abstract":"Blockade of the renin-angiotensin and the endothelin (ET) systems ameliorates fibrous airway obliteration in rat tracheal allografts. The aim of this study was to test which of these pharmacologic interventions attenuates the process more effectively, and whether combination therapy confers additional benefit. Rat tracheas were heterotopically transplanted from Brown-Norway donors into Lewis recipients. Recipients received the dual endothelin-1 (ET-1) receptor blocker, bosentan (100 mg/kg), the angiotensin-converting enzyme (ACE) inhibitor, ramipril (5 mg/kg), bosentan plus ramipril (doses as just noted) or vehicle. Grafts were harvested at Days 7 and 21 for morphometric studies and molecular analysis by real-time polymerase chain reaction (PCR). At Day 21, bosentan and ramipril treatment reduced the percentage of luminal occlusion compared with vehicle to a similar extent. In animals that received the combined treatment, luminal obliteration was further reduced compared with the respective monotherapies. Furthermore, rats treated with bosentan plus ramipril showed a lower percent of epithelial necrosis. The beneficial effects of bosentan and ramipril, alone or in combination, were associated with reduced mRNA levels of transforming growth factor (TGF)-beta1 and platelet-derived growth factor (PDGF)-A in the tracheal allografts. Our data suggest that ET receptor blockade prevents fibrous airway obliteration to a similar extent as ACE inhibition in this model. Interruption of both pathways provides superior graft protection as compared with single-system blockade.","internal_url":"https://www.academia.edu/20849289/Effects_of_Blockade_of_the_Renin_Angiotensin_and_Endothelin_Systems_on_Experimental_Bronchiolitis_Obliterans","translated_internal_url":"","created_at":"2016-01-26T13:29:52.437-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42005307,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":41920127,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41920127/thumbnails/1.jpg","file_name":"j.healun.2006.08.007.pdf20160202-27199-nx5qmg","download_url":"https://www.academia.edu/attachments/41920127/download_file?st=MTczMjQyMzc4NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effects_of_Blockade_of_the_Renin_Angiote.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41920127/j.healun.2006.08.007-libre.pdf20160202-27199-nx5qmg?1454481024=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_Blockade_of_the_Renin_Angiote.pdf\u0026Expires=1732427384\u0026Signature=Wjuqu0EjMTl1~b6Sugs2UmHpqZRwTtemFQ1Tm2Dzu0G9FYP5xGTi7up2qN6mVQctJwj-WvygclzEjPzY5m-vIuNSzk75V7coAG3ZJXVJTQU6fJ-51MzyZRd~YnmliIQJr2~paK~NMpg14KXpMyRJZ-ie3JKXfFxHnWGQJgxI7NdwgxhB59~Mzg1UTAD7GA44kDH2~5PbREYdBKetY2E~r6JKNV7wBPOQRUUCOBtcky6yccy5TOF88Ow2DT753KJwgmKVGwe3BXmW3ybetjefMkd~VWM7u7A0tubZqJJg2LKnHYHybifIwIGGMtcb-gkuJd6ymiZaOhgFjPtY06UgDw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effects_of_Blockade_of_the_Renin_Angiotensin_and_Endothelin_Systems_on_Experimental_Bronchiolitis_Obliterans","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":42005307,"first_name":"Ildiko","middle_initials":"","last_name":"Horvath","page_name":"HorvathIldiko","domain_name":"sote","created_at":"2016-01-24T08:22:24.674-08:00","display_name":"Ildiko Horvath","url":"https://sote.academia.edu/HorvathIldiko"},"attachments":[{"id":41920127,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41920127/thumbnails/1.jpg","file_name":"j.healun.2006.08.007.pdf20160202-27199-nx5qmg","download_url":"https://www.academia.edu/attachments/41920127/download_file?st=MTczMjQyMzc4NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effects_of_Blockade_of_the_Renin_Angiote.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41920127/j.healun.2006.08.007-libre.pdf20160202-27199-nx5qmg?1454481024=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_Blockade_of_the_Renin_Angiote.pdf\u0026Expires=1732427384\u0026Signature=Wjuqu0EjMTl1~b6Sugs2UmHpqZRwTtemFQ1Tm2Dzu0G9FYP5xGTi7up2qN6mVQctJwj-WvygclzEjPzY5m-vIuNSzk75V7coAG3ZJXVJTQU6fJ-51MzyZRd~YnmliIQJr2~paK~NMpg14KXpMyRJZ-ie3JKXfFxHnWGQJgxI7NdwgxhB59~Mzg1UTAD7GA44kDH2~5PbREYdBKetY2E~r6JKNV7wBPOQRUUCOBtcky6yccy5TOF88Ow2DT753KJwgmKVGwe3BXmW3ybetjefMkd~VWM7u7A0tubZqJJg2LKnHYHybifIwIGGMtcb-gkuJd6ymiZaOhgFjPtY06UgDw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":90002,"name":"Renin Angiotensin Aldosterone System","url":"https://www.academia.edu/Documents/in/Renin_Angiotensin_Aldosterone_System"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":424553,"name":"Trachea","url":"https://www.academia.edu/Documents/in/Trachea"},{"id":448603,"name":"Necrosis","url":"https://www.academia.edu/Documents/in/Necrosis"},{"id":527900,"name":"Transforming Growth Factor Beta","url":"https://www.academia.edu/Documents/in/Transforming_Growth_Factor_Beta"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy"},{"id":1036494,"name":"Heart and Lung Transplantation","url":"https://www.academia.edu/Documents/in/Heart_and_Lung_Transplantation"},{"id":1227768,"name":"Angiotensin Converting Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme_Inhibitors"},{"id":1738993,"name":"Bronchiolitis Obliterans","url":"https://www.academia.edu/Documents/in/Bronchiolitis_Obliterans"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation"},{"id":2027622,"name":"The Heart","url":"https://www.academia.edu/Documents/in/The_Heart"},{"id":2262625,"name":"Endothelins","url":"https://www.academia.edu/Documents/in/Endothelins"}],"urls":[]}, dispatcherData: dispatcherData }); 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Rat tracheas were transplanted from male and female Brown-Norway donors into male and female Lewis recipients. Grafts were harvested at days 7, 14 and 21 for morphometric studies and molecular analysis by real-time PCR. At each time point, both epithelial injury and the extent of luminal occlusion of the tracheal allografts were similar between the groups. Furthermore, intragraft mRNA expression for transforming growth factor (TGF)-β1, interleukin (IL)-2 and interferon (INF)-γ did not differ between the groups. Our data suggest that gender has no impact on the development of obliterative airway disease in this transplant model.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Experimental and Molecular Pathology","grobid_abstract_attachment_id":41596795},"translated_abstract":null,"internal_url":"https://www.academia.edu/20849288/No_gender_difference_in_development_of_obliterative_airway_disease_in_rat_tracheal_allografts","translated_internal_url":"","created_at":"2016-01-26T13:29:52.221-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42005307,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":41596795,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41596795/thumbnails/1.jpg","file_name":"j.yexmp.2006.06.002.pdf20160126-3487-1yy8qj7","download_url":"https://www.academia.edu/attachments/41596795/download_file?st=MTczMjQyMzc4NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"No_gender_difference_in_development_of_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41596795/j.yexmp.2006.06.002-libre.pdf20160126-3487-1yy8qj7?1453846304=\u0026response-content-disposition=attachment%3B+filename%3DNo_gender_difference_in_development_of_o.pdf\u0026Expires=1732427384\u0026Signature=KW2N1kKWdQk1KKzEX2M9CMycggCeWt3zow2Ce~Olvj~LqeywGg2oBWflpBu6NcTui4A5XjpxZ5T6HNDurcVeWzwtR2yjfsN~~A1dWB-UhJowEbyq4PpGaD1bVVC7i-M001NQMOW1oPnDWlumCZiLGa3Xd7E40rKoVM7UI4VrJ1~UBqZHqFGlSWbGg~X75PGWWlBZqXAPkRRAts8zXfCKDMyP4y6M2Vva5jhxC-mLC802V-OKOmqRSUTpHUdIehb-Gn6aebqkk4HR-ahRZwWPmNyxZLcDezPvwP8Llo7iF3gmspnt6PRfRTI6LLl4HE2Pv7CrL~SN8s37Sgt3Droq1w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"No_gender_difference_in_development_of_obliterative_airway_disease_in_rat_tracheal_allografts","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":42005307,"first_name":"Ildiko","middle_initials":"","last_name":"Horvath","page_name":"HorvathIldiko","domain_name":"sote","created_at":"2016-01-24T08:22:24.674-08:00","display_name":"Ildiko 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data-work-id="20849287"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20849287/Adenosine_and_Adenosine_Receptors_in_the_Pathomechanism_and_Treatment_of_Respiratory_Diseases"><img alt="Research paper thumbnail of Adenosine and Adenosine Receptors in the Pathomechanism and Treatment of Respiratory Diseases" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849287/Adenosine_and_Adenosine_Receptors_in_the_Pathomechanism_and_Treatment_of_Respiratory_Diseases">Adenosine and Adenosine Receptors in the Pathomechanism and Treatment of Respiratory Diseases</a></div><div class="wp-workCard_item"><span>Current Medicinal Chemistry</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It has been known for a long time that inhaled adenosine-monophosphate (AMP) induces airway obstr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It has been known for a long time that inhaled adenosine-monophosphate (AMP) induces airway obstruction in asthmatic patients, but not in healthy subjects. The mechanism of AMP is indirect and occurs via its decay product, adenosine. It stimulates mast cells through its low-affinity receptor A2B to release histamine, which ultimately leads to smooth muscle contraction. This feature of adenosine reveals its pro-inflammatory function, which may play important role in asthma. Indeed, mice lacking adenosine deaminase (ADA), an enzyme which decomposes adenosine, develop asthma-like disorder with elevated IgE, eosinophilia and airway hyperresponsiveness. Human studies showed elevated adenosine levels in bronchoalveolar lavage and exhaled breath condensate of asthmatics as compared to healthy people. Furthermore, certain human ADA phenotypes are associated with prevalence of asthma. These data suggest a protective role for ADA and a pro-inflammatory function for adenosine in asthma. The role of adenosine in inflammatory processes, however, is not unequivocal. Some in vitro studies showed that adenosine binding to its high-affinity receptor A2A results in inhibition of leukotriene synthesis or function of adhesion molecules. It is possible that the concentration of adenosine in lung tissues determines whether it promotes or reduces inflammation. Adenosine has also been associated with other respiratory diseases such as fibrosis, sarcoidosis, cystic fibrosis or tuberculosis. Identification of adenosine receptor subtypes and their role in the pathomechanism of respiratory diseases may provide new therapeutical targets. This review aims to summarize the role of adenosine and adenosine receptors in asthma and other pulmonary disorders.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849287"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849287"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20849287; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20849287]").text(description); $(".js-view-count[data-work-id=20849287]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20849287; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20849287']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20849287, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20849287]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20849287,"title":"Adenosine and Adenosine Receptors in the Pathomechanism and Treatment of Respiratory Diseases","translated_title":"","metadata":{"abstract":"It has been known for a long time that inhaled adenosine-monophosphate (AMP) induces airway obstruction in asthmatic patients, but not in healthy subjects. The mechanism of AMP is indirect and occurs via its decay product, adenosine. It stimulates mast cells through its low-affinity receptor A2B to release histamine, which ultimately leads to smooth muscle contraction. This feature of adenosine reveals its pro-inflammatory function, which may play important role in asthma. Indeed, mice lacking adenosine deaminase (ADA), an enzyme which decomposes adenosine, develop asthma-like disorder with elevated IgE, eosinophilia and airway hyperresponsiveness. Human studies showed elevated adenosine levels in bronchoalveolar lavage and exhaled breath condensate of asthmatics as compared to healthy people. Furthermore, certain human ADA phenotypes are associated with prevalence of asthma. These data suggest a protective role for ADA and a pro-inflammatory function for adenosine in asthma. The role of adenosine in inflammatory processes, however, is not unequivocal. Some in vitro studies showed that adenosine binding to its high-affinity receptor A2A results in inhibition of leukotriene synthesis or function of adhesion molecules. It is possible that the concentration of adenosine in lung tissues determines whether it promotes or reduces inflammation. Adenosine has also been associated with other respiratory diseases such as fibrosis, sarcoidosis, cystic fibrosis or tuberculosis. Identification of adenosine receptor subtypes and their role in the pathomechanism of respiratory diseases may provide new therapeutical targets. This review aims to summarize the role of adenosine and adenosine receptors in asthma and other pulmonary disorders.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Current Medicinal Chemistry"},"translated_abstract":"It has been known for a long time that inhaled adenosine-monophosphate (AMP) induces airway obstruction in asthmatic patients, but not in healthy subjects. The mechanism of AMP is indirect and occurs via its decay product, adenosine. It stimulates mast cells through its low-affinity receptor A2B to release histamine, which ultimately leads to smooth muscle contraction. This feature of adenosine reveals its pro-inflammatory function, which may play important role in asthma. Indeed, mice lacking adenosine deaminase (ADA), an enzyme which decomposes adenosine, develop asthma-like disorder with elevated IgE, eosinophilia and airway hyperresponsiveness. Human studies showed elevated adenosine levels in bronchoalveolar lavage and exhaled breath condensate of asthmatics as compared to healthy people. Furthermore, certain human ADA phenotypes are associated with prevalence of asthma. These data suggest a protective role for ADA and a pro-inflammatory function for adenosine in asthma. The role of adenosine in inflammatory processes, however, is not unequivocal. Some in vitro studies showed that adenosine binding to its high-affinity receptor A2A results in inhibition of leukotriene synthesis or function of adhesion molecules. It is possible that the concentration of adenosine in lung tissues determines whether it promotes or reduces inflammation. Adenosine has also been associated with other respiratory diseases such as fibrosis, sarcoidosis, cystic fibrosis or tuberculosis. Identification of adenosine receptor subtypes and their role in the pathomechanism of respiratory diseases may provide new therapeutical targets. This review aims to summarize the role of adenosine and adenosine receptors in asthma and other pulmonary disorders.","internal_url":"https://www.academia.edu/20849287/Adenosine_and_Adenosine_Receptors_in_the_Pathomechanism_and_Treatment_of_Respiratory_Diseases","translated_internal_url":"","created_at":"2016-01-26T13:29:52.034-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42005307,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Adenosine_and_Adenosine_Receptors_in_the_Pathomechanism_and_Treatment_of_Respiratory_Diseases","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42005307,"first_name":"Ildiko","middle_initials":"","last_name":"Horvath","page_name":"HorvathIldiko","domain_name":"sote","created_at":"2016-01-24T08:22:24.674-08:00","display_name":"Ildiko Horvath","url":"https://sote.academia.edu/HorvathIldiko"},"attachments":[],"research_interests":[{"id":61232,"name":"Adenosine","url":"https://www.academia.edu/Documents/in/Adenosine"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":72771,"name":"Respiratory Disease","url":"https://www.academia.edu/Documents/in/Respiratory_Disease"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung"},{"id":587539,"name":"Airway Obstruction","url":"https://www.academia.edu/Documents/in/Airway_Obstruction"},{"id":1147382,"name":"Adenosine Deaminase","url":"https://www.academia.edu/Documents/in/Adenosine_Deaminase"},{"id":1818690,"name":"Adenosine monophosphate","url":"https://www.academia.edu/Documents/in/Adenosine_monophosphate"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20849286"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20849286/Exhaled_Breath_Condensate_in_Asthma_From_Bench_to_Bedside"><img alt="Research paper thumbnail of Exhaled Breath Condensate in Asthma: From Bench to Bedside" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849286/Exhaled_Breath_Condensate_in_Asthma_From_Bench_to_Bedside">Exhaled Breath Condensate in Asthma: From Bench to Bedside</a></div><div class="wp-workCard_item"><span>Current Medicinal Chemistry</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The need for non-invasive assessment of airway inflammation is imperative, since inflammatory air...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The need for non-invasive assessment of airway inflammation is imperative, since inflammatory airway diseases, such as asthma and COPD, are characterized by variation in their clinical presentation throughout their course. Exhaled breath condensate (EBC) collection represents a rather appealing method that can be used to conveniently and noninvasively collect a wide range of volatile and non-volatile molecules from the respiratory tract, without affecting airway function or inflammation. Although promising, EBC is currently used only as a research tool, due to the lack of appropriate standardization and the absence of reference values. A large number of mediators of inflammation, oxidative and nitrosative stress, including adenosine, ammonia, hydrogen peroxide, isoprostanes, leukotrienes, prostanoids, nitrogen oxides, peptides and cytokines, have been studied in EBC. This review focuses mainly on the presentation of the above biomarkers in asthma as well as on the effect of various factors on their concentrations. Concentrations of such mediators have been shown to be related to the underlying asthma and its severity and to be modulated by therapeutic interventions. Despite the encouraging positive results up-to-date, the introduction of EBC in everyday clinical practice requires the work-out of some methodological pitfalls, the standardization of EBC collection, and finally the identification of a reliable biomarker which is reproducible, has normal values and provides information for the underlying inflammatory process and the response to treatment. So far none of the parameters studied in EBC fulfils the aforementioned requirements.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849286"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849286"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20849286; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20849286]").text(description); $(".js-view-count[data-work-id=20849286]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20849286; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20849286']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20849286, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20849286]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20849286,"title":"Exhaled Breath Condensate in Asthma: From Bench to Bedside","translated_title":"","metadata":{"abstract":"The need for non-invasive assessment of airway inflammation is imperative, since inflammatory airway diseases, such as asthma and COPD, are characterized by variation in their clinical presentation throughout their course. Exhaled breath condensate (EBC) collection represents a rather appealing method that can be used to conveniently and noninvasively collect a wide range of volatile and non-volatile molecules from the respiratory tract, without affecting airway function or inflammation. Although promising, EBC is currently used only as a research tool, due to the lack of appropriate standardization and the absence of reference values. A large number of mediators of inflammation, oxidative and nitrosative stress, including adenosine, ammonia, hydrogen peroxide, isoprostanes, leukotrienes, prostanoids, nitrogen oxides, peptides and cytokines, have been studied in EBC. This review focuses mainly on the presentation of the above biomarkers in asthma as well as on the effect of various factors on their concentrations. Concentrations of such mediators have been shown to be related to the underlying asthma and its severity and to be modulated by therapeutic interventions. Despite the encouraging positive results up-to-date, the introduction of EBC in everyday clinical practice requires the work-out of some methodological pitfalls, the standardization of EBC collection, and finally the identification of a reliable biomarker which is reproducible, has normal values and provides information for the underlying inflammatory process and the response to treatment. So far none of the parameters studied in EBC fulfils the aforementioned requirements.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Current Medicinal Chemistry"},"translated_abstract":"The need for non-invasive assessment of airway inflammation is imperative, since inflammatory airway diseases, such as asthma and COPD, are characterized by variation in their clinical presentation throughout their course. Exhaled breath condensate (EBC) collection represents a rather appealing method that can be used to conveniently and noninvasively collect a wide range of volatile and non-volatile molecules from the respiratory tract, without affecting airway function or inflammation. Although promising, EBC is currently used only as a research tool, due to the lack of appropriate standardization and the absence of reference values. A large number of mediators of inflammation, oxidative and nitrosative stress, including adenosine, ammonia, hydrogen peroxide, isoprostanes, leukotrienes, prostanoids, nitrogen oxides, peptides and cytokines, have been studied in EBC. This review focuses mainly on the presentation of the above biomarkers in asthma as well as on the effect of various factors on their concentrations. Concentrations of such mediators have been shown to be related to the underlying asthma and its severity and to be modulated by therapeutic interventions. Despite the encouraging positive results up-to-date, the introduction of EBC in everyday clinical practice requires the work-out of some methodological pitfalls, the standardization of EBC collection, and finally the identification of a reliable biomarker which is reproducible, has normal values and provides information for the underlying inflammatory process and the response to treatment. So far none of the parameters studied in EBC fulfils the aforementioned requirements.","internal_url":"https://www.academia.edu/20849286/Exhaled_Breath_Condensate_in_Asthma_From_Bench_to_Bedside","translated_internal_url":"","created_at":"2016-01-26T13:29:51.845-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42005307,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Exhaled_Breath_Condensate_in_Asthma_From_Bench_to_Bedside","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42005307,"first_name":"Ildiko","middle_initials":"","last_name":"Horvath","page_name":"HorvathIldiko","domain_name":"sote","created_at":"2016-01-24T08:22:24.674-08:00","display_name":"Ildiko Horvath","url":"https://sote.academia.edu/HorvathIldiko"},"attachments":[],"research_interests":[{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":106428,"name":"Eicosanoids","url":"https://www.academia.edu/Documents/in/Eicosanoids"},{"id":274826,"name":"Hydrogen Peroxide","url":"https://www.academia.edu/Documents/in/Hydrogen_Peroxide"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":809002,"name":"Nitrogen Oxides","url":"https://www.academia.edu/Documents/in/Nitrogen_Oxides"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20849275"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20849275/L_Arginine_Pathway_in_COPD_Patients_with_Acute_Exacerbation_A_New_Potential_Biomarker"><img alt="Research paper thumbnail of L-Arginine Pathway in COPD Patients with Acute Exacerbation: A New Potential Biomarker" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849275/L_Arginine_Pathway_in_COPD_Patients_with_Acute_Exacerbation_A_New_Potential_Biomarker">L-Arginine Pathway in COPD Patients with Acute Exacerbation: A New Potential Biomarker</a></div><div class="wp-workCard_item"><span>COPD</span><span>, Jan 29, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains a major cause of mor...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains a major cause of mortality. Clinical criteria of AECOPD are subjective. Biomarkers for AECOPD may aid in the initiation of early treatment. Increased production of asymmetric and symmetric dimethylarginine (ADMA, SDMA) is related to hypoxia. In COPD, a rise in ADMA results in a shift of L-arginine breakdown, contributing to airway obstruction. We aimed to compare serum levels of ADMA, SDMA and L-arginine in patients with and without AECOPD. L-arginine metabolites quantified by high-performance liquid chromatography in venous blood samples and partial capillary oxygen pressure were prospectively investigated in 32 patients with COPD, 12 with AECOPD and 30 healthy subjects. Both ADMA and SDMA were significantly higher in AECOPD compared to stable COPD (p = 0.004 and p &lt; 0.001, respectively). Oxygen content in capillaries correlated with serum ADMA concentration. However, the concentration of L-arginine was...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849275"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849275"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20849275; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20849275]").text(description); $(".js-view-count[data-work-id=20849275]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20849275; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20849275']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20849275, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20849275]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20849275,"title":"L-Arginine Pathway in COPD Patients with Acute Exacerbation: A New Potential Biomarker","translated_title":"","metadata":{"abstract":"Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains a major cause of mortality. Clinical criteria of AECOPD are subjective. Biomarkers for AECOPD may aid in the initiation of early treatment. Increased production of asymmetric and symmetric dimethylarginine (ADMA, SDMA) is related to hypoxia. In COPD, a rise in ADMA results in a shift of L-arginine breakdown, contributing to airway obstruction. We aimed to compare serum levels of ADMA, SDMA and L-arginine in patients with and without AECOPD. L-arginine metabolites quantified by high-performance liquid chromatography in venous blood samples and partial capillary oxygen pressure were prospectively investigated in 32 patients with COPD, 12 with AECOPD and 30 healthy subjects. Both ADMA and SDMA were significantly higher in AECOPD compared to stable COPD (p = 0.004 and p \u0026lt; 0.001, respectively). Oxygen content in capillaries correlated with serum ADMA concentration. However, the concentration of L-arginine was...","publication_date":{"day":29,"month":1,"year":2015,"errors":{}},"publication_name":"COPD"},"translated_abstract":"Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains a major cause of mortality. Clinical criteria of AECOPD are subjective. Biomarkers for AECOPD may aid in the initiation of early treatment. Increased production of asymmetric and symmetric dimethylarginine (ADMA, SDMA) is related to hypoxia. In COPD, a rise in ADMA results in a shift of L-arginine breakdown, contributing to airway obstruction. We aimed to compare serum levels of ADMA, SDMA and L-arginine in patients with and without AECOPD. L-arginine metabolites quantified by high-performance liquid chromatography in venous blood samples and partial capillary oxygen pressure were prospectively investigated in 32 patients with COPD, 12 with AECOPD and 30 healthy subjects. Both ADMA and SDMA were significantly higher in AECOPD compared to stable COPD (p = 0.004 and p \u0026lt; 0.001, respectively). Oxygen content in capillaries correlated with serum ADMA concentration. However, the concentration of L-arginine was...","internal_url":"https://www.academia.edu/20849275/L_Arginine_Pathway_in_COPD_Patients_with_Acute_Exacerbation_A_New_Potential_Biomarker","translated_internal_url":"","created_at":"2016-01-26T13:28:42.403-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42005307,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"L_Arginine_Pathway_in_COPD_Patients_with_Acute_Exacerbation_A_New_Potential_Biomarker","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42005307,"first_name":"Ildiko","middle_initials":"","last_name":"Horvath","page_name":"HorvathIldiko","domain_name":"sote","created_at":"2016-01-24T08:22:24.674-08:00","display_name":"Ildiko Horvath","url":"https://sote.academia.edu/HorvathIldiko"},"attachments":[],"research_interests":[{"id":65341,"name":"COPD","url":"https://www.academia.edu/Documents/in/COPD"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20849274"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20849274/Comparison_of_Nasal_and_Oral_Inhalation_during_Exhaled_Breath_Condensate_Collection"><img alt="Research paper thumbnail of Comparison of Nasal and Oral Inhalation during Exhaled Breath Condensate Collection" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849274/Comparison_of_Nasal_and_Oral_Inhalation_during_Exhaled_Breath_Condensate_Collection">Comparison of Nasal and Oral Inhalation during Exhaled Breath Condensate Collection</a></div><div class="wp-workCard_item"><span>American Journal of Respiratory and Critical Care Medicine</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Analysis of exhaled breath condensate is a method for noninvasive assessment of the lung. Condens...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Analysis of exhaled breath condensate is a method for noninvasive assessment of the lung. Condensate can be collected with a nose clip (subjects inhale and exhale via the mouth) or without it (subjects inhale via the nose and exhale via the mouth), but the mode of inhalation may influence condensate volume and mediator levels. We compared condensate volume and adenosine, ammonia, and thromboxane B2 levels in young healthy volunteers (n = 25) in samples collected for 10 minutes from subjects with or without a nose clip. Patients with allergic rhinitis (n = 8) were also studied to assess the effect of upper airway inflammation on mediator levels. Adenosine, ammonia, and thromboxane B2 levels were determined by HPLC, spectrophotometry, and radioimmunoassay, respectively. Volume of condensate was significantly higher without nose clip than that with nose clip (mean +/- SD, 2321 +/- 736 microl and 1746 +/- 400 microl, respectively; p = 0.0001). We found no significant difference in any mediator levels between these two collection modes in healthy volunteers, but adenosine showed a tendency to differ between oral and nasal inhalation in patients with allergic rhinitis. Our data indicate that whereas a greater volume of condensate can be obtained when subjects inhale through their noses, the mode of inhalation does not influence mediator levels in young healthy volunteers, but may affect these levels in patients with allergic rhinitis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849274"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849274"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20849274; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20849274]").text(description); $(".js-view-count[data-work-id=20849274]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20849274; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20849274']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20849274, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20849274]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20849274,"title":"Comparison of Nasal and Oral Inhalation during Exhaled Breath Condensate Collection","translated_title":"","metadata":{"abstract":"Analysis of exhaled breath condensate is a method for noninvasive assessment of the lung. Condensate can be collected with a nose clip (subjects inhale and exhale via the mouth) or without it (subjects inhale via the nose and exhale via the mouth), but the mode of inhalation may influence condensate volume and mediator levels. We compared condensate volume and adenosine, ammonia, and thromboxane B2 levels in young healthy volunteers (n = 25) in samples collected for 10 minutes from subjects with or without a nose clip. Patients with allergic rhinitis (n = 8) were also studied to assess the effect of upper airway inflammation on mediator levels. Adenosine, ammonia, and thromboxane B2 levels were determined by HPLC, spectrophotometry, and radioimmunoassay, respectively. Volume of condensate was significantly higher without nose clip than that with nose clip (mean +/- SD, 2321 +/- 736 microl and 1746 +/- 400 microl, respectively; p = 0.0001). We found no significant difference in any mediator levels between these two collection modes in healthy volunteers, but adenosine showed a tendency to differ between oral and nasal inhalation in patients with allergic rhinitis. Our data indicate that whereas a greater volume of condensate can be obtained when subjects inhale through their noses, the mode of inhalation does not influence mediator levels in young healthy volunteers, but may affect these levels in patients with allergic rhinitis.","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"American Journal of Respiratory and Critical Care Medicine"},"translated_abstract":"Analysis of exhaled breath condensate is a method for noninvasive assessment of the lung. Condensate can be collected with a nose clip (subjects inhale and exhale via the mouth) or without it (subjects inhale via the nose and exhale via the mouth), but the mode of inhalation may influence condensate volume and mediator levels. We compared condensate volume and adenosine, ammonia, and thromboxane B2 levels in young healthy volunteers (n = 25) in samples collected for 10 minutes from subjects with or without a nose clip. Patients with allergic rhinitis (n = 8) were also studied to assess the effect of upper airway inflammation on mediator levels. Adenosine, ammonia, and thromboxane B2 levels were determined by HPLC, spectrophotometry, and radioimmunoassay, respectively. Volume of condensate was significantly higher without nose clip than that with nose clip (mean +/- SD, 2321 +/- 736 microl and 1746 +/- 400 microl, respectively; p = 0.0001). We found no significant difference in any mediator levels between these two collection modes in healthy volunteers, but adenosine showed a tendency to differ between oral and nasal inhalation in patients with allergic rhinitis. Our data indicate that whereas a greater volume of condensate can be obtained when subjects inhale through their noses, the mode of inhalation does not influence mediator levels in young healthy volunteers, but may affect these levels in patients with allergic rhinitis.","internal_url":"https://www.academia.edu/20849274/Comparison_of_Nasal_and_Oral_Inhalation_during_Exhaled_Breath_Condensate_Collection","translated_internal_url":"","created_at":"2016-01-26T13:28:42.166-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42005307,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Comparison_of_Nasal_and_Oral_Inhalation_during_Exhaled_Breath_Condensate_Collection","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42005307,"first_name":"Ildiko","middle_initials":"","last_name":"Horvath","page_name":"HorvathIldiko","domain_name":"sote","created_at":"2016-01-24T08:22:24.674-08:00","display_name":"Ildiko Horvath","url":"https://sote.academia.edu/HorvathIldiko"},"attachments":[],"research_interests":[{"id":28850,"name":"Linear models","url":"https://www.academia.edu/Documents/in/Linear_models"},{"id":61232,"name":"Adenosine","url":"https://www.academia.edu/Documents/in/Adenosine"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":151448,"name":"American","url":"https://www.academia.edu/Documents/in/American"},{"id":219724,"name":"Ammonia","url":"https://www.academia.edu/Documents/in/Ammonia"},{"id":328135,"name":"Exhaled breath condensate","url":"https://www.academia.edu/Documents/in/Exhaled_breath_condensate"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":390808,"name":"Vital Capacity","url":"https://www.academia.edu/Documents/in/Vital_Capacity"},{"id":394395,"name":"Inhalation","url":"https://www.academia.edu/Documents/in/Inhalation"},{"id":402186,"name":"Mouth","url":"https://www.academia.edu/Documents/in/Mouth"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":936874,"name":"Bias (Epidemiology)","url":"https://www.academia.edu/Documents/in/Bias_Epidemiology_"},{"id":985144,"name":"Nose","url":"https://www.academia.edu/Documents/in/Nose"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies"},{"id":2195595,"name":"Tidal volume","url":"https://www.academia.edu/Documents/in/Tidal_volume"},{"id":2224933,"name":"Constriction","url":"https://www.academia.edu/Documents/in/Constriction"}],"urls":[]}, dispatcherData: dispatcherData }); 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href="https://www.academia.edu/20849299/No_gender_difference_in_development_of_obliterative_airway_disease_in_rat_tracheal_allografts"><img alt="Research paper thumbnail of No gender difference in development of obliterative airway disease in rat tracheal allografts" class="work-thumbnail" src="https://attachments.academia-assets.com/41596794/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849299/No_gender_difference_in_development_of_obliterative_airway_disease_in_rat_tracheal_allografts">No gender difference in development of obliterative airway disease in rat tracheal allografts</a></div><div class="wp-workCard_item"><span>Experimental and Molecular Pathology</span><span>, Dec 31, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span 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href="https://www.academia.edu/20849296/A_kil%C3%A9gzett_nitrog%C3%A9n_monoxid_jelent%C3%B4s%C3%A9ge_asthma_bronchial%C3%A9ban_Elk%C3%BCl%C3%B6n%C3%ADt%C3%B4_diagnosztika_%C3%A9s_k%C3%B6vet%C3%A9s">A kilégzett nitrogén-monoxid jelentôsége asthma bronchialéban Elkülönítô diagnosztika és követés</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849296"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849296"><i class="fa fa-spinner 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class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849295/Gefitinib_as_a_3rd_line_treatment_possibility_in_the_case_of_advanced_non_small_cell_bronchus_carcinoma_patients">Gefitinib as a 3rd line treatment possibility in the case of advanced non-small-cell bronchus-carcinoma patients</a></div><div class="wp-workCard_item"><span>Medicina thoracalis</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Like in the past decades, the experiments for developing a cure for lung cancer, are still one of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Like in the past decades, the experiments for developing a cure for lung cancer, are still one of the main challenges in ocology. Our therapeutic possibilities are expanded, but the inoperable non small-cellular lung cancer patients&#39; changes of survival are inconspicuous (5year survival-regardless of treatment - is around 14%). The rapid development of molecular genetics, the automatization of drug-synthesis put down the basis of targeted molecular tumor therapy. In our paper we present two cases from our database, in which using 3rd line gefitinib as chemotherapeutic method we achieved important radiological and clinical regression. In the case of our patients, after using the traditional cytotoxic method, we applied gefitinib, as a new the targeted therapy and obtained important radiological regression and quality of life improvement.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="39ec1abaf91771e4b5c5be016a88d235" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41596796,"asset_id":20849295,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41596796/download_file?st=MTczMjQyMzc4NSw4LjIyMi4yMDguMTQ2&st=MTczMjQyMzc4Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849295"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849295"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20849295; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20849295]").text(description); $(".js-view-count[data-work-id=20849295]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20849295; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20849295']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20849295, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "39ec1abaf91771e4b5c5be016a88d235" } } $('.js-work-strip[data-work-id=20849295]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20849295,"title":"Gefitinib as a 3rd line treatment possibility in the case of advanced non-small-cell bronchus-carcinoma patients","translated_title":"","metadata":{"abstract":"Like in the past decades, the experiments for developing a cure for lung cancer, are still one of the main challenges in ocology. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20849293"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20849293/Zu_den_akuten_pulmonalen_Wirkungen_bei_Verwendung_einer_E_Zigarette"><img alt="Research paper thumbnail of Zu den akuten pulmonalen Wirkungen bei Verwendung einer E-Zigarette" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849293/Zu_den_akuten_pulmonalen_Wirkungen_bei_Verwendung_einer_E_Zigarette">Zu den akuten pulmonalen Wirkungen bei Verwendung einer E-Zigarette</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Electronic nicotine delivery systems (ENDS), also known as e-cigarettes, are advertised ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Electronic nicotine delivery systems (ENDS), also known as e-cigarettes, are advertised and sold as an alternative nicotine delivery method useful for smoking cessation. However, the potential harmful effects of e-cigarettes on the human body have not been fully investigated and the related health risks have not been listed. The English full text version of this article is available at SpringerLink (under “Supplemental”). Zusammenfassung Elektronische Nikotinabgabesysteme, auch E-Zigaretten genannt, werden als alternative Methode zur Versorgung mit Nikotin beworben und verkauft, die hilfreich sein soll, wenn man mit dem Rauchen aufhören will. Allerdings sind bisher die möglichen schädlichen Wirkungen von E-Zigaretten auf den menschlichen Körper nicht vollständig untersucht und die gesundheitsbezogenen Risiken nicht aufgeführt worden. 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However, the potential harmful effects of e-cigarettes on the human body have not been fully investigated and the related health risks have not been listed. The English full text version of this article is available at SpringerLink (under “Supplemental”). Zusammenfassung Elektronische Nikotinabgabesysteme, auch E-Zigaretten genannt, werden als alternative Methode zur Versorgung mit Nikotin beworben und verkauft, die hilfreich sein soll, wenn man mit dem Rauchen aufhören will. Allerdings sind bisher die möglichen schädlichen Wirkungen von E-Zigaretten auf den menschlichen Körper nicht vollständig untersucht und die gesundheitsbezogenen Risiken nicht aufgeführt worden. 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Allerdings sind bisher die möglichen schädlichen Wirkungen von E-Zigaretten auf den menschlichen Körper nicht vollständig untersucht und die gesundheitsbezogenen Risiken nicht aufgeführt worden. Die englische Volltextversion dieses Beitrags ist über SpringerLink (unter „Supplemental“) verfügbar.","internal_url":"https://www.academia.edu/20849293/Zu_den_akuten_pulmonalen_Wirkungen_bei_Verwendung_einer_E_Zigarette","translated_internal_url":"","created_at":"2016-01-26T13:29:53.148-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42005307,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Zu_den_akuten_pulmonalen_Wirkungen_bei_Verwendung_einer_E_Zigarette","translated_slug":"","page_count":null,"language":"de","content_type":"Work","owner":{"id":42005307,"first_name":"Ildiko","middle_initials":"","last_name":"Horvath","page_name":"HorvathIldiko","domain_name":"sote","created_at":"2016-01-24T08:22:24.674-08:00","display_name":"Ildiko Horvath","url":"https://sote.academia.edu/HorvathIldiko"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20849292"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20849292/Exhaled_carbon_monoxide_in_airway_diseases_from_research_findings_to_clinical_relevance"><img alt="Research paper thumbnail of Exhaled carbon monoxide in airway diseases: from research findings to clinical relevance" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849292/Exhaled_carbon_monoxide_in_airway_diseases_from_research_findings_to_clinical_relevance">Exhaled carbon monoxide in airway diseases: from research findings to clinical relevance</a></div><div class="wp-workCard_item"><span>Journal of Breath Research</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Breath tests have gained increasing interest in recent years mainly driven by the unmet clinical ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Breath tests have gained increasing interest in recent years mainly driven by the unmet clinical need to monitor airway diseases and to obtain information of unravelled aspects of respiratory disorders. Carbon monoxide is present in the exhaled breath and has been suggested to reflect ongoing oxidative stress, even if there are some confounding factors limiting its clinical usefulness. Increased concentration of exhaled carbon monoxide has been demonstrated in different acute and chronic airway diseases including allergic rhinitis, asthma, bronchiectasis, and post transplant bronchiolitis obliterans syndrome. Although exhaled carbon monoxide might not prove as a clinically useful biomarker of airway diseases, its measurement has helped to understand the place of heme oxygenase activity in allergic and non-allergic airway diseases. The scope of this review is the exciting field of exhaled carbon monoxide in airway diseases.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849292"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849292"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20849292; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20849292]").text(description); $(".js-view-count[data-work-id=20849292]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20849292; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20849292']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20849292, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20849292]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20849292,"title":"Exhaled carbon monoxide in airway diseases: from research findings to clinical relevance","translated_title":"","metadata":{"abstract":"Breath tests have gained increasing interest in recent years mainly driven by the unmet clinical need to monitor airway diseases and to obtain information of unravelled aspects of respiratory disorders. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20849289"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20849289/Effects_of_Blockade_of_the_Renin_Angiotensin_and_Endothelin_Systems_on_Experimental_Bronchiolitis_Obliterans"><img alt="Research paper thumbnail of Effects of Blockade of the Renin–Angiotensin and Endothelin Systems on Experimental Bronchiolitis Obliterans" class="work-thumbnail" src="https://attachments.academia-assets.com/41920127/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849289/Effects_of_Blockade_of_the_Renin_Angiotensin_and_Endothelin_Systems_on_Experimental_Bronchiolitis_Obliterans">Effects of Blockade of the Renin–Angiotensin and Endothelin Systems on Experimental Bronchiolitis Obliterans</a></div><div class="wp-workCard_item"><span>The Journal of Heart and Lung Transplantation</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Blockade of the renin-angiotensin and the endothelin (ET) systems ameliorates fibrous airway obli...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Blockade of the renin-angiotensin and the endothelin (ET) systems ameliorates fibrous airway obliteration in rat tracheal allografts. The aim of this study was to test which of these pharmacologic interventions attenuates the process more effectively, and whether combination therapy confers additional benefit. Rat tracheas were heterotopically transplanted from Brown-Norway donors into Lewis recipients. Recipients received the dual endothelin-1 (ET-1) receptor blocker, bosentan (100 mg/kg), the angiotensin-converting enzyme (ACE) inhibitor, ramipril (5 mg/kg), bosentan plus ramipril (doses as just noted) or vehicle. Grafts were harvested at Days 7 and 21 for morphometric studies and molecular analysis by real-time polymerase chain reaction (PCR). At Day 21, bosentan and ramipril treatment reduced the percentage of luminal occlusion compared with vehicle to a similar extent. In animals that received the combined treatment, luminal obliteration was further reduced compared with the respective monotherapies. Furthermore, rats treated with bosentan plus ramipril showed a lower percent of epithelial necrosis. The beneficial effects of bosentan and ramipril, alone or in combination, were associated with reduced mRNA levels of transforming growth factor (TGF)-beta1 and platelet-derived growth factor (PDGF)-A in the tracheal allografts. Our data suggest that ET receptor blockade prevents fibrous airway obliteration to a similar extent as ACE inhibition in this model. Interruption of both pathways provides superior graft protection as compared with single-system blockade.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="912403a98b1f1503638b1f4385fde33f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41920127,"asset_id":20849289,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41920127/download_file?st=MTczMjQyMzc4NSw4LjIyMi4yMDguMTQ2&st=MTczMjQyMzc4NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849289"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849289"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20849289; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20849289]").text(description); $(".js-view-count[data-work-id=20849289]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20849289; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20849289']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20849289, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "912403a98b1f1503638b1f4385fde33f" } } $('.js-work-strip[data-work-id=20849289]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20849289,"title":"Effects of Blockade of the Renin–Angiotensin and Endothelin Systems on Experimental Bronchiolitis Obliterans","translated_title":"","metadata":{"abstract":"Blockade of the renin-angiotensin and the endothelin (ET) systems ameliorates fibrous airway obliteration in rat tracheal allografts. 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Rat tracheas were heterotopically transplanted from Brown-Norway donors into Lewis recipients. Recipients received the dual endothelin-1 (ET-1) receptor blocker, bosentan (100 mg/kg), the angiotensin-converting enzyme (ACE) inhibitor, ramipril (5 mg/kg), bosentan plus ramipril (doses as just noted) or vehicle. Grafts were harvested at Days 7 and 21 for morphometric studies and molecular analysis by real-time polymerase chain reaction (PCR). At Day 21, bosentan and ramipril treatment reduced the percentage of luminal occlusion compared with vehicle to a similar extent. In animals that received the combined treatment, luminal obliteration was further reduced compared with the respective monotherapies. Furthermore, rats treated with bosentan plus ramipril showed a lower percent of epithelial necrosis. The beneficial effects of bosentan and ramipril, alone or in combination, were associated with reduced mRNA levels of transforming growth factor (TGF)-beta1 and platelet-derived growth factor (PDGF)-A in the tracheal allografts. Our data suggest that ET receptor blockade prevents fibrous airway obliteration to a similar extent as ACE inhibition in this model. Interruption of both pathways provides superior graft protection as compared with single-system blockade.","internal_url":"https://www.academia.edu/20849289/Effects_of_Blockade_of_the_Renin_Angiotensin_and_Endothelin_Systems_on_Experimental_Bronchiolitis_Obliterans","translated_internal_url":"","created_at":"2016-01-26T13:29:52.437-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42005307,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":41920127,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41920127/thumbnails/1.jpg","file_name":"j.healun.2006.08.007.pdf20160202-27199-nx5qmg","download_url":"https://www.academia.edu/attachments/41920127/download_file?st=MTczMjQyMzc4NSw4LjIyMi4yMDguMTQ2&st=MTczMjQyMzc4NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effects_of_Blockade_of_the_Renin_Angiote.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41920127/j.healun.2006.08.007-libre.pdf20160202-27199-nx5qmg?1454481024=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_Blockade_of_the_Renin_Angiote.pdf\u0026Expires=1732427384\u0026Signature=Wjuqu0EjMTl1~b6Sugs2UmHpqZRwTtemFQ1Tm2Dzu0G9FYP5xGTi7up2qN6mVQctJwj-WvygclzEjPzY5m-vIuNSzk75V7coAG3ZJXVJTQU6fJ-51MzyZRd~YnmliIQJr2~paK~NMpg14KXpMyRJZ-ie3JKXfFxHnWGQJgxI7NdwgxhB59~Mzg1UTAD7GA44kDH2~5PbREYdBKetY2E~r6JKNV7wBPOQRUUCOBtcky6yccy5TOF88Ow2DT753KJwgmKVGwe3BXmW3ybetjefMkd~VWM7u7A0tubZqJJg2LKnHYHybifIwIGGMtcb-gkuJd6ymiZaOhgFjPtY06UgDw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effects_of_Blockade_of_the_Renin_Angiotensin_and_Endothelin_Systems_on_Experimental_Bronchiolitis_Obliterans","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":42005307,"first_name":"Ildiko","middle_initials":"","last_name":"Horvath","page_name":"HorvathIldiko","domain_name":"sote","created_at":"2016-01-24T08:22:24.674-08:00","display_name":"Ildiko Horvath","url":"https://sote.academia.edu/HorvathIldiko"},"attachments":[{"id":41920127,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/41920127/thumbnails/1.jpg","file_name":"j.healun.2006.08.007.pdf20160202-27199-nx5qmg","download_url":"https://www.academia.edu/attachments/41920127/download_file?st=MTczMjQyMzc4NSw4LjIyMi4yMDguMTQ2&st=MTczMjQyMzc4NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effects_of_Blockade_of_the_Renin_Angiote.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/41920127/j.healun.2006.08.007-libre.pdf20160202-27199-nx5qmg?1454481024=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_Blockade_of_the_Renin_Angiote.pdf\u0026Expires=1732427384\u0026Signature=Wjuqu0EjMTl1~b6Sugs2UmHpqZRwTtemFQ1Tm2Dzu0G9FYP5xGTi7up2qN6mVQctJwj-WvygclzEjPzY5m-vIuNSzk75V7coAG3ZJXVJTQU6fJ-51MzyZRd~YnmliIQJr2~paK~NMpg14KXpMyRJZ-ie3JKXfFxHnWGQJgxI7NdwgxhB59~Mzg1UTAD7GA44kDH2~5PbREYdBKetY2E~r6JKNV7wBPOQRUUCOBtcky6yccy5TOF88Ow2DT753KJwgmKVGwe3BXmW3ybetjefMkd~VWM7u7A0tubZqJJg2LKnHYHybifIwIGGMtcb-gkuJd6ymiZaOhgFjPtY06UgDw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":90002,"name":"Renin Angiotensin Aldosterone System","url":"https://www.academia.edu/Documents/in/Renin_Angiotensin_Aldosterone_System"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":424553,"name":"Trachea","url":"https://www.academia.edu/Documents/in/Trachea"},{"id":448603,"name":"Necrosis","url":"https://www.academia.edu/Documents/in/Necrosis"},{"id":527900,"name":"Transforming Growth Factor Beta","url":"https://www.academia.edu/Documents/in/Transforming_Growth_Factor_Beta"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy"},{"id":1036494,"name":"Heart and Lung Transplantation","url":"https://www.academia.edu/Documents/in/Heart_and_Lung_Transplantation"},{"id":1227768,"name":"Angiotensin Converting Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme_Inhibitors"},{"id":1738993,"name":"Bronchiolitis Obliterans","url":"https://www.academia.edu/Documents/in/Bronchiolitis_Obliterans"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation"},{"id":2027622,"name":"The Heart","url":"https://www.academia.edu/Documents/in/The_Heart"},{"id":2262625,"name":"Endothelins","url":"https://www.academia.edu/Documents/in/Endothelins"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20849288"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20849288/No_gender_difference_in_development_of_obliterative_airway_disease_in_rat_tracheal_allografts"><img alt="Research paper thumbnail of No gender difference in development of obliterative airway disease in rat tracheal allografts" class="work-thumbnail" src="https://attachments.academia-assets.com/41596795/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849288/No_gender_difference_in_development_of_obliterative_airway_disease_in_rat_tracheal_allografts">No gender difference in development of obliterative airway disease in rat tracheal allografts</a></div><div class="wp-workCard_item"><span>Experimental and Molecular Pathology</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4d3cf3451d25402df8e48df7e39e40db" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":41596795,"asset_id":20849288,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/41596795/download_file?st=MTczMjQyMzc4NSw4LjIyMi4yMDguMTQ2&st=MTczMjQyMzc4NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849288"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849288"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20849288; 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data-work-id="20849287"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20849287/Adenosine_and_Adenosine_Receptors_in_the_Pathomechanism_and_Treatment_of_Respiratory_Diseases"><img alt="Research paper thumbnail of Adenosine and Adenosine Receptors in the Pathomechanism and Treatment of Respiratory Diseases" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849287/Adenosine_and_Adenosine_Receptors_in_the_Pathomechanism_and_Treatment_of_Respiratory_Diseases">Adenosine and Adenosine Receptors in the Pathomechanism and Treatment of Respiratory Diseases</a></div><div class="wp-workCard_item"><span>Current Medicinal Chemistry</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It has been known for a long time that inhaled adenosine-monophosphate (AMP) induces airway obstr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It has been known for a long time that inhaled adenosine-monophosphate (AMP) induces airway obstruction in asthmatic patients, but not in healthy subjects. The mechanism of AMP is indirect and occurs via its decay product, adenosine. It stimulates mast cells through its low-affinity receptor A2B to release histamine, which ultimately leads to smooth muscle contraction. This feature of adenosine reveals its pro-inflammatory function, which may play important role in asthma. Indeed, mice lacking adenosine deaminase (ADA), an enzyme which decomposes adenosine, develop asthma-like disorder with elevated IgE, eosinophilia and airway hyperresponsiveness. Human studies showed elevated adenosine levels in bronchoalveolar lavage and exhaled breath condensate of asthmatics as compared to healthy people. Furthermore, certain human ADA phenotypes are associated with prevalence of asthma. These data suggest a protective role for ADA and a pro-inflammatory function for adenosine in asthma. The role of adenosine in inflammatory processes, however, is not unequivocal. Some in vitro studies showed that adenosine binding to its high-affinity receptor A2A results in inhibition of leukotriene synthesis or function of adhesion molecules. It is possible that the concentration of adenosine in lung tissues determines whether it promotes or reduces inflammation. Adenosine has also been associated with other respiratory diseases such as fibrosis, sarcoidosis, cystic fibrosis or tuberculosis. Identification of adenosine receptor subtypes and their role in the pathomechanism of respiratory diseases may provide new therapeutical targets. This review aims to summarize the role of adenosine and adenosine receptors in asthma and other pulmonary disorders.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849287"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849287"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20849287; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20849287]").text(description); $(".js-view-count[data-work-id=20849287]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20849287; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20849287']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20849287, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20849287]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20849287,"title":"Adenosine and Adenosine Receptors in the Pathomechanism and Treatment of Respiratory Diseases","translated_title":"","metadata":{"abstract":"It has been known for a long time that inhaled adenosine-monophosphate (AMP) induces airway obstruction in asthmatic patients, but not in healthy subjects. The mechanism of AMP is indirect and occurs via its decay product, adenosine. It stimulates mast cells through its low-affinity receptor A2B to release histamine, which ultimately leads to smooth muscle contraction. This feature of adenosine reveals its pro-inflammatory function, which may play important role in asthma. Indeed, mice lacking adenosine deaminase (ADA), an enzyme which decomposes adenosine, develop asthma-like disorder with elevated IgE, eosinophilia and airway hyperresponsiveness. Human studies showed elevated adenosine levels in bronchoalveolar lavage and exhaled breath condensate of asthmatics as compared to healthy people. Furthermore, certain human ADA phenotypes are associated with prevalence of asthma. These data suggest a protective role for ADA and a pro-inflammatory function for adenosine in asthma. The role of adenosine in inflammatory processes, however, is not unequivocal. Some in vitro studies showed that adenosine binding to its high-affinity receptor A2A results in inhibition of leukotriene synthesis or function of adhesion molecules. It is possible that the concentration of adenosine in lung tissues determines whether it promotes or reduces inflammation. Adenosine has also been associated with other respiratory diseases such as fibrosis, sarcoidosis, cystic fibrosis or tuberculosis. Identification of adenosine receptor subtypes and their role in the pathomechanism of respiratory diseases may provide new therapeutical targets. This review aims to summarize the role of adenosine and adenosine receptors in asthma and other pulmonary disorders.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Current Medicinal Chemistry"},"translated_abstract":"It has been known for a long time that inhaled adenosine-monophosphate (AMP) induces airway obstruction in asthmatic patients, but not in healthy subjects. The mechanism of AMP is indirect and occurs via its decay product, adenosine. It stimulates mast cells through its low-affinity receptor A2B to release histamine, which ultimately leads to smooth muscle contraction. This feature of adenosine reveals its pro-inflammatory function, which may play important role in asthma. Indeed, mice lacking adenosine deaminase (ADA), an enzyme which decomposes adenosine, develop asthma-like disorder with elevated IgE, eosinophilia and airway hyperresponsiveness. Human studies showed elevated adenosine levels in bronchoalveolar lavage and exhaled breath condensate of asthmatics as compared to healthy people. Furthermore, certain human ADA phenotypes are associated with prevalence of asthma. These data suggest a protective role for ADA and a pro-inflammatory function for adenosine in asthma. The role of adenosine in inflammatory processes, however, is not unequivocal. Some in vitro studies showed that adenosine binding to its high-affinity receptor A2A results in inhibition of leukotriene synthesis or function of adhesion molecules. It is possible that the concentration of adenosine in lung tissues determines whether it promotes or reduces inflammation. Adenosine has also been associated with other respiratory diseases such as fibrosis, sarcoidosis, cystic fibrosis or tuberculosis. Identification of adenosine receptor subtypes and their role in the pathomechanism of respiratory diseases may provide new therapeutical targets. This review aims to summarize the role of adenosine and adenosine receptors in asthma and other pulmonary disorders.","internal_url":"https://www.academia.edu/20849287/Adenosine_and_Adenosine_Receptors_in_the_Pathomechanism_and_Treatment_of_Respiratory_Diseases","translated_internal_url":"","created_at":"2016-01-26T13:29:52.034-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42005307,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Adenosine_and_Adenosine_Receptors_in_the_Pathomechanism_and_Treatment_of_Respiratory_Diseases","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42005307,"first_name":"Ildiko","middle_initials":"","last_name":"Horvath","page_name":"HorvathIldiko","domain_name":"sote","created_at":"2016-01-24T08:22:24.674-08:00","display_name":"Ildiko Horvath","url":"https://sote.academia.edu/HorvathIldiko"},"attachments":[],"research_interests":[{"id":61232,"name":"Adenosine","url":"https://www.academia.edu/Documents/in/Adenosine"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":72771,"name":"Respiratory Disease","url":"https://www.academia.edu/Documents/in/Respiratory_Disease"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung"},{"id":587539,"name":"Airway Obstruction","url":"https://www.academia.edu/Documents/in/Airway_Obstruction"},{"id":1147382,"name":"Adenosine Deaminase","url":"https://www.academia.edu/Documents/in/Adenosine_Deaminase"},{"id":1818690,"name":"Adenosine monophosphate","url":"https://www.academia.edu/Documents/in/Adenosine_monophosphate"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20849286"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20849286/Exhaled_Breath_Condensate_in_Asthma_From_Bench_to_Bedside"><img alt="Research paper thumbnail of Exhaled Breath Condensate in Asthma: From Bench to Bedside" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849286/Exhaled_Breath_Condensate_in_Asthma_From_Bench_to_Bedside">Exhaled Breath Condensate in Asthma: From Bench to Bedside</a></div><div class="wp-workCard_item"><span>Current Medicinal Chemistry</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The need for non-invasive assessment of airway inflammation is imperative, since inflammatory air...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The need for non-invasive assessment of airway inflammation is imperative, since inflammatory airway diseases, such as asthma and COPD, are characterized by variation in their clinical presentation throughout their course. Exhaled breath condensate (EBC) collection represents a rather appealing method that can be used to conveniently and noninvasively collect a wide range of volatile and non-volatile molecules from the respiratory tract, without affecting airway function or inflammation. Although promising, EBC is currently used only as a research tool, due to the lack of appropriate standardization and the absence of reference values. A large number of mediators of inflammation, oxidative and nitrosative stress, including adenosine, ammonia, hydrogen peroxide, isoprostanes, leukotrienes, prostanoids, nitrogen oxides, peptides and cytokines, have been studied in EBC. This review focuses mainly on the presentation of the above biomarkers in asthma as well as on the effect of various factors on their concentrations. Concentrations of such mediators have been shown to be related to the underlying asthma and its severity and to be modulated by therapeutic interventions. Despite the encouraging positive results up-to-date, the introduction of EBC in everyday clinical practice requires the work-out of some methodological pitfalls, the standardization of EBC collection, and finally the identification of a reliable biomarker which is reproducible, has normal values and provides information for the underlying inflammatory process and the response to treatment. So far none of the parameters studied in EBC fulfils the aforementioned requirements.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849286"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849286"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20849286; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20849286]").text(description); $(".js-view-count[data-work-id=20849286]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20849286; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20849286']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20849286, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20849286]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20849286,"title":"Exhaled Breath Condensate in Asthma: From Bench to Bedside","translated_title":"","metadata":{"abstract":"The need for non-invasive assessment of airway inflammation is imperative, since inflammatory airway diseases, such as asthma and COPD, are characterized by variation in their clinical presentation throughout their course. Exhaled breath condensate (EBC) collection represents a rather appealing method that can be used to conveniently and noninvasively collect a wide range of volatile and non-volatile molecules from the respiratory tract, without affecting airway function or inflammation. Although promising, EBC is currently used only as a research tool, due to the lack of appropriate standardization and the absence of reference values. A large number of mediators of inflammation, oxidative and nitrosative stress, including adenosine, ammonia, hydrogen peroxide, isoprostanes, leukotrienes, prostanoids, nitrogen oxides, peptides and cytokines, have been studied in EBC. This review focuses mainly on the presentation of the above biomarkers in asthma as well as on the effect of various factors on their concentrations. Concentrations of such mediators have been shown to be related to the underlying asthma and its severity and to be modulated by therapeutic interventions. Despite the encouraging positive results up-to-date, the introduction of EBC in everyday clinical practice requires the work-out of some methodological pitfalls, the standardization of EBC collection, and finally the identification of a reliable biomarker which is reproducible, has normal values and provides information for the underlying inflammatory process and the response to treatment. So far none of the parameters studied in EBC fulfils the aforementioned requirements.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Current Medicinal Chemistry"},"translated_abstract":"The need for non-invasive assessment of airway inflammation is imperative, since inflammatory airway diseases, such as asthma and COPD, are characterized by variation in their clinical presentation throughout their course. Exhaled breath condensate (EBC) collection represents a rather appealing method that can be used to conveniently and noninvasively collect a wide range of volatile and non-volatile molecules from the respiratory tract, without affecting airway function or inflammation. Although promising, EBC is currently used only as a research tool, due to the lack of appropriate standardization and the absence of reference values. A large number of mediators of inflammation, oxidative and nitrosative stress, including adenosine, ammonia, hydrogen peroxide, isoprostanes, leukotrienes, prostanoids, nitrogen oxides, peptides and cytokines, have been studied in EBC. This review focuses mainly on the presentation of the above biomarkers in asthma as well as on the effect of various factors on their concentrations. Concentrations of such mediators have been shown to be related to the underlying asthma and its severity and to be modulated by therapeutic interventions. Despite the encouraging positive results up-to-date, the introduction of EBC in everyday clinical practice requires the work-out of some methodological pitfalls, the standardization of EBC collection, and finally the identification of a reliable biomarker which is reproducible, has normal values and provides information for the underlying inflammatory process and the response to treatment. So far none of the parameters studied in EBC fulfils the aforementioned requirements.","internal_url":"https://www.academia.edu/20849286/Exhaled_Breath_Condensate_in_Asthma_From_Bench_to_Bedside","translated_internal_url":"","created_at":"2016-01-26T13:29:51.845-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42005307,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Exhaled_Breath_Condensate_in_Asthma_From_Bench_to_Bedside","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42005307,"first_name":"Ildiko","middle_initials":"","last_name":"Horvath","page_name":"HorvathIldiko","domain_name":"sote","created_at":"2016-01-24T08:22:24.674-08:00","display_name":"Ildiko Horvath","url":"https://sote.academia.edu/HorvathIldiko"},"attachments":[],"research_interests":[{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":106428,"name":"Eicosanoids","url":"https://www.academia.edu/Documents/in/Eicosanoids"},{"id":274826,"name":"Hydrogen Peroxide","url":"https://www.academia.edu/Documents/in/Hydrogen_Peroxide"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":809002,"name":"Nitrogen Oxides","url":"https://www.academia.edu/Documents/in/Nitrogen_Oxides"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20849275"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20849275/L_Arginine_Pathway_in_COPD_Patients_with_Acute_Exacerbation_A_New_Potential_Biomarker"><img alt="Research paper thumbnail of L-Arginine Pathway in COPD Patients with Acute Exacerbation: A New Potential Biomarker" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849275/L_Arginine_Pathway_in_COPD_Patients_with_Acute_Exacerbation_A_New_Potential_Biomarker">L-Arginine Pathway in COPD Patients with Acute Exacerbation: A New Potential Biomarker</a></div><div class="wp-workCard_item"><span>COPD</span><span>, Jan 29, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains a major cause of mor...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains a major cause of mortality. Clinical criteria of AECOPD are subjective. Biomarkers for AECOPD may aid in the initiation of early treatment. Increased production of asymmetric and symmetric dimethylarginine (ADMA, SDMA) is related to hypoxia. In COPD, a rise in ADMA results in a shift of L-arginine breakdown, contributing to airway obstruction. We aimed to compare serum levels of ADMA, SDMA and L-arginine in patients with and without AECOPD. L-arginine metabolites quantified by high-performance liquid chromatography in venous blood samples and partial capillary oxygen pressure were prospectively investigated in 32 patients with COPD, 12 with AECOPD and 30 healthy subjects. Both ADMA and SDMA were significantly higher in AECOPD compared to stable COPD (p = 0.004 and p &lt; 0.001, respectively). Oxygen content in capillaries correlated with serum ADMA concentration. However, the concentration of L-arginine was...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849275"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849275"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20849275; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20849275]").text(description); $(".js-view-count[data-work-id=20849275]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20849275; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20849275']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20849275, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20849275]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20849275,"title":"L-Arginine Pathway in COPD Patients with Acute Exacerbation: A New Potential Biomarker","translated_title":"","metadata":{"abstract":"Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains a major cause of mortality. Clinical criteria of AECOPD are subjective. Biomarkers for AECOPD may aid in the initiation of early treatment. Increased production of asymmetric and symmetric dimethylarginine (ADMA, SDMA) is related to hypoxia. In COPD, a rise in ADMA results in a shift of L-arginine breakdown, contributing to airway obstruction. We aimed to compare serum levels of ADMA, SDMA and L-arginine in patients with and without AECOPD. L-arginine metabolites quantified by high-performance liquid chromatography in venous blood samples and partial capillary oxygen pressure were prospectively investigated in 32 patients with COPD, 12 with AECOPD and 30 healthy subjects. Both ADMA and SDMA were significantly higher in AECOPD compared to stable COPD (p = 0.004 and p \u0026lt; 0.001, respectively). Oxygen content in capillaries correlated with serum ADMA concentration. However, the concentration of L-arginine was...","publication_date":{"day":29,"month":1,"year":2015,"errors":{}},"publication_name":"COPD"},"translated_abstract":"Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains a major cause of mortality. Clinical criteria of AECOPD are subjective. Biomarkers for AECOPD may aid in the initiation of early treatment. Increased production of asymmetric and symmetric dimethylarginine (ADMA, SDMA) is related to hypoxia. In COPD, a rise in ADMA results in a shift of L-arginine breakdown, contributing to airway obstruction. We aimed to compare serum levels of ADMA, SDMA and L-arginine in patients with and without AECOPD. L-arginine metabolites quantified by high-performance liquid chromatography in venous blood samples and partial capillary oxygen pressure were prospectively investigated in 32 patients with COPD, 12 with AECOPD and 30 healthy subjects. Both ADMA and SDMA were significantly higher in AECOPD compared to stable COPD (p = 0.004 and p \u0026lt; 0.001, respectively). Oxygen content in capillaries correlated with serum ADMA concentration. However, the concentration of L-arginine was...","internal_url":"https://www.academia.edu/20849275/L_Arginine_Pathway_in_COPD_Patients_with_Acute_Exacerbation_A_New_Potential_Biomarker","translated_internal_url":"","created_at":"2016-01-26T13:28:42.403-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42005307,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"L_Arginine_Pathway_in_COPD_Patients_with_Acute_Exacerbation_A_New_Potential_Biomarker","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42005307,"first_name":"Ildiko","middle_initials":"","last_name":"Horvath","page_name":"HorvathIldiko","domain_name":"sote","created_at":"2016-01-24T08:22:24.674-08:00","display_name":"Ildiko Horvath","url":"https://sote.academia.edu/HorvathIldiko"},"attachments":[],"research_interests":[{"id":65341,"name":"COPD","url":"https://www.academia.edu/Documents/in/COPD"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20849274"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20849274/Comparison_of_Nasal_and_Oral_Inhalation_during_Exhaled_Breath_Condensate_Collection"><img alt="Research paper thumbnail of Comparison of Nasal and Oral Inhalation during Exhaled Breath Condensate Collection" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20849274/Comparison_of_Nasal_and_Oral_Inhalation_during_Exhaled_Breath_Condensate_Collection">Comparison of Nasal and Oral Inhalation during Exhaled Breath Condensate Collection</a></div><div class="wp-workCard_item"><span>American Journal of Respiratory and Critical Care Medicine</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Analysis of exhaled breath condensate is a method for noninvasive assessment of the lung. Condens...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Analysis of exhaled breath condensate is a method for noninvasive assessment of the lung. Condensate can be collected with a nose clip (subjects inhale and exhale via the mouth) or without it (subjects inhale via the nose and exhale via the mouth), but the mode of inhalation may influence condensate volume and mediator levels. We compared condensate volume and adenosine, ammonia, and thromboxane B2 levels in young healthy volunteers (n = 25) in samples collected for 10 minutes from subjects with or without a nose clip. Patients with allergic rhinitis (n = 8) were also studied to assess the effect of upper airway inflammation on mediator levels. Adenosine, ammonia, and thromboxane B2 levels were determined by HPLC, spectrophotometry, and radioimmunoassay, respectively. Volume of condensate was significantly higher without nose clip than that with nose clip (mean +/- SD, 2321 +/- 736 microl and 1746 +/- 400 microl, respectively; p = 0.0001). We found no significant difference in any mediator levels between these two collection modes in healthy volunteers, but adenosine showed a tendency to differ between oral and nasal inhalation in patients with allergic rhinitis. Our data indicate that whereas a greater volume of condensate can be obtained when subjects inhale through their noses, the mode of inhalation does not influence mediator levels in young healthy volunteers, but may affect these levels in patients with allergic rhinitis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20849274"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20849274"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20849274; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20849274]").text(description); $(".js-view-count[data-work-id=20849274]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20849274; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20849274']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20849274, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20849274]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20849274,"title":"Comparison of Nasal and Oral Inhalation during Exhaled Breath Condensate Collection","translated_title":"","metadata":{"abstract":"Analysis of exhaled breath condensate is a method for noninvasive assessment of the lung. Condensate can be collected with a nose clip (subjects inhale and exhale via the mouth) or without it (subjects inhale via the nose and exhale via the mouth), but the mode of inhalation may influence condensate volume and mediator levels. We compared condensate volume and adenosine, ammonia, and thromboxane B2 levels in young healthy volunteers (n = 25) in samples collected for 10 minutes from subjects with or without a nose clip. Patients with allergic rhinitis (n = 8) were also studied to assess the effect of upper airway inflammation on mediator levels. Adenosine, ammonia, and thromboxane B2 levels were determined by HPLC, spectrophotometry, and radioimmunoassay, respectively. Volume of condensate was significantly higher without nose clip than that with nose clip (mean +/- SD, 2321 +/- 736 microl and 1746 +/- 400 microl, respectively; p = 0.0001). We found no significant difference in any mediator levels between these two collection modes in healthy volunteers, but adenosine showed a tendency to differ between oral and nasal inhalation in patients with allergic rhinitis. Our data indicate that whereas a greater volume of condensate can be obtained when subjects inhale through their noses, the mode of inhalation does not influence mediator levels in young healthy volunteers, but may affect these levels in patients with allergic rhinitis.","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"American Journal of Respiratory and Critical Care Medicine"},"translated_abstract":"Analysis of exhaled breath condensate is a method for noninvasive assessment of the lung. Condensate can be collected with a nose clip (subjects inhale and exhale via the mouth) or without it (subjects inhale via the nose and exhale via the mouth), but the mode of inhalation may influence condensate volume and mediator levels. We compared condensate volume and adenosine, ammonia, and thromboxane B2 levels in young healthy volunteers (n = 25) in samples collected for 10 minutes from subjects with or without a nose clip. Patients with allergic rhinitis (n = 8) were also studied to assess the effect of upper airway inflammation on mediator levels. Adenosine, ammonia, and thromboxane B2 levels were determined by HPLC, spectrophotometry, and radioimmunoassay, respectively. Volume of condensate was significantly higher without nose clip than that with nose clip (mean +/- SD, 2321 +/- 736 microl and 1746 +/- 400 microl, respectively; p = 0.0001). We found no significant difference in any mediator levels between these two collection modes in healthy volunteers, but adenosine showed a tendency to differ between oral and nasal inhalation in patients with allergic rhinitis. Our data indicate that whereas a greater volume of condensate can be obtained when subjects inhale through their noses, the mode of inhalation does not influence mediator levels in young healthy volunteers, but may affect these levels in patients with allergic rhinitis.","internal_url":"https://www.academia.edu/20849274/Comparison_of_Nasal_and_Oral_Inhalation_during_Exhaled_Breath_Condensate_Collection","translated_internal_url":"","created_at":"2016-01-26T13:28:42.166-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":42005307,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Comparison_of_Nasal_and_Oral_Inhalation_during_Exhaled_Breath_Condensate_Collection","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":42005307,"first_name":"Ildiko","middle_initials":"","last_name":"Horvath","page_name":"HorvathIldiko","domain_name":"sote","created_at":"2016-01-24T08:22:24.674-08:00","display_name":"Ildiko Horvath","url":"https://sote.academia.edu/HorvathIldiko"},"attachments":[],"research_interests":[{"id":28850,"name":"Linear models","url":"https://www.academia.edu/Documents/in/Linear_models"},{"id":61232,"name":"Adenosine","url":"https://www.academia.edu/Documents/in/Adenosine"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":151448,"name":"American","url":"https://www.academia.edu/Documents/in/American"},{"id":219724,"name":"Ammonia","url":"https://www.academia.edu/Documents/in/Ammonia"},{"id":328135,"name":"Exhaled breath condensate","url":"https://www.academia.edu/Documents/in/Exhaled_breath_condensate"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":390808,"name":"Vital Capacity","url":"https://www.academia.edu/Documents/in/Vital_Capacity"},{"id":394395,"name":"Inhalation","url":"https://www.academia.edu/Documents/in/Inhalation"},{"id":402186,"name":"Mouth","url":"https://www.academia.edu/Documents/in/Mouth"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":936874,"name":"Bias (Epidemiology)","url":"https://www.academia.edu/Documents/in/Bias_Epidemiology_"},{"id":985144,"name":"Nose","url":"https://www.academia.edu/Documents/in/Nose"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies"},{"id":2195595,"name":"Tidal volume","url":"https://www.academia.edu/Documents/in/Tidal_volume"},{"id":2224933,"name":"Constriction","url":"https://www.academia.edu/Documents/in/Constriction"}],"urls":[]}, dispatcherData: dispatcherData }); 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