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class="vector-toc-link" href="#Effets_secondaires"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Effets secondaires</span> </div> </a> <ul id="toc-Effets_secondaires-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Biosimilaire" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Biosimilaire"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Biosimilaire</span> </div> </a> <ul id="toc-Biosimilaire-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Autres_molécules_anti-CD20" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Autres_molécules_anti-CD20"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Autres molécules anti-CD20</span> </div> </a> <ul id="toc-Autres_molécules_anti-CD20-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Marché" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Marché"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Marché</span> </div> </a> <ul id="toc-Marché-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Notes_et_références" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Notes_et_références"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Notes et références</span> </div> </a> <ul id="toc-Notes_et_références-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Voir_aussi" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Voir_aussi"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Voir aussi</span> </div> </a> <button aria-controls="toc-Voir_aussi-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Afficher / masquer la sous-section Voir aussi</span> </button> <ul id="toc-Voir_aussi-sublist" class="vector-toc-list"> <li id="toc-Articles_connexes" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Articles_connexes"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.1</span> <span>Articles connexes</span> </div> </a> <ul id="toc-Articles_connexes-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Liens_externes" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Liens_externes"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.2</span> <span>Liens externes</span> </div> </a> <ul id="toc-Liens_externes-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sommaire" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Basculer la table des matières" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Basculer la table des matières</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Rituximab</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Aller à un article dans une autre langue. Disponible en 33 langues." > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-33" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">33 langues</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%B1%D9%8A%D8%AA%D9%88%D9%83%D8%B3%D9%8A%D9%85%D8%A7%D8%A8" title="ريتوكسيماب – arabe" lang="ar" hreflang="ar" data-title="ريتوكسيماب" data-language-autonym="العربية" data-language-local-name="arabe" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D8%B1%DB%8C%D8%AA%D9%88%DA%A9%D8%B3%DB%8C%E2%80%8C%D9%85%D8%A8" title="ریتوکسی‌مب – South Azerbaijani" lang="azb" hreflang="azb" data-title="ریتوکسی‌مب" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Rituximab" title="Rituximab – catalan" lang="ca" hreflang="ca" data-title="Rituximab" data-language-autonym="Català" data-language-local-name="catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Rituximab" title="Rituximab – tchèque" lang="cs" hreflang="cs" data-title="Rituximab" data-language-autonym="Čeština" data-language-local-name="tchèque" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Rituximab" title="Rituximab – allemand" lang="de" hreflang="de" data-title="Rituximab" data-language-autonym="Deutsch" data-language-local-name="allemand" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%A1%CE%B9%CF%84%CE%BF%CF%85%CE%BE%CE%B9%CE%BC%CE%AC%CE%BC%CF%80%CE%B7" title="Ριτουξιμάμπη – grec" lang="el" hreflang="el" data-title="Ριτουξιμάμπη" data-language-autonym="Ελληνικά" data-language-local-name="grec" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Rituximab" title="Rituximab – anglais" lang="en" hreflang="en" data-title="Rituximab" data-language-autonym="English" data-language-local-name="anglais" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Rituksimabo" title="Rituksimabo – espéranto" lang="eo" hreflang="eo" data-title="Rituksimabo" data-language-autonym="Esperanto" data-language-local-name="espéranto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Rituximab" title="Rituximab – espagnol" lang="es" hreflang="es" data-title="Rituximab" data-language-autonym="Español" data-language-local-name="espagnol" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%B1%DB%8C%D8%AA%D9%88%DA%A9%D8%B3%DB%8C%E2%80%8C%D9%85%D8%A8" title="ریتوکسی‌مب – persan" lang="fa" hreflang="fa" data-title="ریتوکسی‌مب" data-language-autonym="فارسی" data-language-local-name="persan" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Rituksimabi" title="Rituksimabi – finnois" lang="fi" hreflang="fi" data-title="Rituksimabi" data-language-autonym="Suomi" data-language-local-name="finnois" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%A8%D7%99%D7%98%D7%95%D7%A7%D7%A1%D7%99%D7%9E%D7%90%D7%91" title="ריטוקסימאב – hébreu" lang="he" hreflang="he" data-title="ריטוקסימאב" data-language-autonym="עברית" data-language-local-name="hébreu" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Rituximab" title="Rituximab – hongrois" lang="hu" hreflang="hu" data-title="Rituximab" data-language-autonym="Magyar" data-language-local-name="hongrois" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D5%8C%D5%AB%D5%BF%D5%B8%D6%82%D6%84%D5%BD%D5%AB%D5%B4%D5%A1%D5%A2" title="Ռիտուքսիմաբ – arménien" lang="hy" hreflang="hy" data-title="Ռիտուքսիմաբ" data-language-autonym="Հայերեն" data-language-local-name="arménien" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Rituksimab" title="Rituksimab – indonésien" lang="id" hreflang="id" data-title="Rituksimab" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonésien" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Rituximab" title="Rituximab – italien" lang="it" hreflang="it" data-title="Rituximab" data-language-autonym="Italiano" data-language-local-name="italien" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%AA%E3%83%84%E3%82%AD%E3%82%B7%E3%83%9E%E3%83%96" title="リツキシマブ – japonais" lang="ja" hreflang="ja" data-title="リツキシマブ" data-language-autonym="日本語" data-language-local-name="japonais" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%A6%AC%ED%88%AD%EC%8B%9C%EB%A7%99" title="리툭시맙 – coréen" lang="ko" hreflang="ko" data-title="리툭시맙" data-language-autonym="한국어" data-language-local-name="coréen" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%A0%D0%B8%D1%82%D1%83%D0%BA%D1%81%D0%B8%D0%BC%D0%B0%D0%B1" title="Ритуксимаб – macédonien" lang="mk" hreflang="mk" data-title="Ритуксимаб" data-language-autonym="Македонски" data-language-local-name="macédonien" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Rituximab" title="Rituximab – néerlandais" lang="nl" hreflang="nl" data-title="Rituximab" data-language-autonym="Nederlands" data-language-local-name="néerlandais" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Rituximab" title="Rituximab – norvégien bokmål" lang="nb" hreflang="nb" data-title="Rituximab" data-language-autonym="Norsk bokmål" data-language-local-name="norvégien bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%B0%E0%AC%BF%E0%AC%9F%E0%AC%95%E0%AD%8D%E0%AC%B8%E0%AC%BF%E0%AC%AE%E0%AC%BE%E0%AC%AC" title="ରିଟକ୍ସିମାବ – odia" lang="or" hreflang="or" data-title="ରିଟକ୍ସିମାବ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Rytuksymab" title="Rytuksymab – polonais" lang="pl" hreflang="pl" data-title="Rytuksymab" data-language-autonym="Polski" data-language-local-name="polonais" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Rituximab" title="Rituximab – portugais" lang="pt" hreflang="pt" data-title="Rituximab" data-language-autonym="Português" data-language-local-name="portugais" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A0%D0%B8%D1%82%D1%83%D0%BA%D1%81%D0%B8%D0%BC%D0%B0%D0%B1" title="Ритуксимаб – russe" lang="ru" hreflang="ru" data-title="Ритуксимаб" data-language-autonym="Русский" data-language-local-name="russe" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Rituksimab" title="Rituksimab – serbo-croate" lang="sh" hreflang="sh" data-title="Rituksimab" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croate" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Rituksimab" title="Rituksimab – slovène" lang="sl" hreflang="sl" data-title="Rituksimab" data-language-autonym="Slovenščina" data-language-local-name="slovène" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Rituksimab" title="Rituksimab – serbe" lang="sr" hreflang="sr" data-title="Rituksimab" data-language-autonym="Српски / srpski" data-language-local-name="serbe" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Rituximab" title="Rituximab – suédois" lang="sv" hreflang="sv" data-title="Rituximab" data-language-autonym="Svenska" data-language-local-name="suédois" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Rituximab" title="Rituximab – turc" lang="tr" hreflang="tr" data-title="Rituximab" data-language-autonym="Türkçe" data-language-local-name="turc" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%A0%D0%B8%D1%82%D1%83%D0%BA%D1%81%D0%B8%D0%BC%D0%B0%D0%B1" title="Ритуксимаб – ukrainien" lang="uk" hreflang="uk" data-title="Ритуксимаб" data-language-autonym="Українська" data-language-local-name="ukrainien" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Rituximab" title="Rituximab – vietnamien" lang="vi" hreflang="vi" data-title="Rituximab" data-language-autonym="Tiếng Việt" data-language-local-name="vietnamien" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%88%A9%E5%A6%A5%E6%98%94%E5%96%AE%E6%8A%97" title="利妥昔單抗 – chinois" lang="zh" hreflang="zh" data-title="利妥昔單抗" data-language-autonym="中文" data-language-local-name="chinois" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a 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<table class="infobox_v2 infobox infobox--frwiki noarchive"> <tbody><tr> <td colspan="2" class="entete defaut" style="background-color:#FFDEAD;color:black;">Rituximab </td></tr> <tr><td colspan="2" style="text-align:center; line-height: 1.5em;"><span typeof="mw:File/Frameless"><a href="/wiki/Fichier:Rituximab.png" class="mw-file-description"><img alt="Image illustrative de l’article Rituximab" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d0/Rituximab.png/220px-Rituximab.png" decoding="async" width="220" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d0/Rituximab.png/330px-Rituximab.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d0/Rituximab.png/440px-Rituximab.png 2x" data-file-width="1020" data-file-height="625" /></a></span> </td></tr> <tr> <td colspan="2" style="text-align:center;">Fragment Fab du rituximab avec épitope protidique</td> </tr><tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#FFDEAD; color:#000000">Identification</th></tr> <tr> <th scope="row"><a href="/wiki/Num%C3%A9ro_CAS" title="Numéro CAS">N<sup>o</sup> CAS</a> </th> <td><span class="reflink plainlinksneverexpand"><span class="noarchive"><a class="external text" href="//tools.wmflabs.org/magnustools/cas.php?cas=174722-31-7&language=fr&title=Rituximab">174722-31-7</a></span></span> </td> </tr> <tr> <th scope="row"> N<sup>o</sup> <a href="/wiki/Agence_europ%C3%A9enne_des_produits_chimiques" title="Agence européenne des produits chimiques">ECHA</a> </th> <td><span class="plainlinks"><span class="noarchive"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.224.382">100.224.382</a></span></span></td> </tr> <tr> <th scope="row"><a href="/wiki/Classification_ATC" title="Classification ATC">Code ATC</a> </th> <td><a href="/wiki/Classe_ATC_L01" title="Classe ATC L01"><span title="ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS, ANTINEOPLASTIC AGENTS, OTHER ANTINEOPLASTIC AGENTS, Monoclonal antibodies, rituximab">L01</span></a><span class="reflink plainlinksneverexpand"><span class="noarchive"><a rel="nofollow" class="external text" href="http://www.whocc.no/atc_ddd_index/?code=L01XC02">XC02</a></span></span> </td> </tr> <tr> <th scope="row">DrugBank </th> <td><span class="plainlinks"><span class="noarchive"><a rel="nofollow" class="external text" href="http://www.drugbank.ca/drugs/DB00073">DB00073</a></span></span> </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#FFDEAD; color:#000000">Propriétés chimiques</th></tr> <tr> <th scope="row"><a href="/wiki/Formule_chimique" title="Formule chimique">Formule</a> </th> <td><a href="/wiki/Carbone" title="Carbone">C</a><sub>6416</sub><a href="/wiki/Hydrog%C3%A8ne" title="Hydrogène">H</a><sub>9874</sub><a href="/wiki/Azote" title="Azote">N</a><sub>1688</sub><a href="/wiki/Oxyg%C3%A8ne" title="Oxygène">O</a><sub>1987</sub><a href="/wiki/Soufre" title="Soufre">S</a><sub>44</sub>  <span class="page_h"><a href="/wiki/C6416H9874N1688O1987S44" class="mw-redirect" title="C6416H9874N1688O1987S44"><small>[Isomères]</small></a></span><br /> </td> </tr> <tr> <th scope="row"><a href="/wiki/Masse_molaire" title="Masse molaire">Masse molaire</a><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite_crochet">[</span>1<span class="cite_crochet">]</span></a></sup> </th> <td>143 858,028 ± 6,978 <a href="/wiki/Gramme" title="Gramme">g</a>/<a href="/wiki/Mole_(unit%C3%A9)" title="Mole (unité)">mol</a> <br /><small>C 53,57 %,  H 6,92 %,  N 16,44 %,  O 22,1 %,  S 0,98 %,  </small> </td> </tr> <tr> <td colspan="2"><hr style="height:2px; background-color:#FFDEAD;" /></td></tr> <tr> <td colspan="2" style="text-align:center;">Unités du <a href="/wiki/Syst%C3%A8me_international_d%27unit%C3%A9s" title="Système international d'unités">SI</a> et <a href="/wiki/Conditions_normales_de_temp%C3%A9rature_et_de_pression" title="Conditions normales de température et de pression"><abbr title="conditions normales de température et de pression">CNTP</abbr></a>, sauf indication contraire.</td> </tr><tr> <td class="navigation-only" colspan="2" style="border-top: 2px #FFDEAD solid; font-size: 80%; background:inherit; color: inherit; text-align: right;"><span class="plainlinks" style="float:left;"><a class="external text" href="https://fr.wikipedia.org/w/index.php?title=Rituximab&action=edit&section=0"><span class="infodoc">modifier</span></a></span> <span typeof="mw:File"><a href="/wiki/Mod%C3%A8le:Infobox_Chimie" title="Consultez la documentation du modèle"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/12px-Info_Simple.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/18px-Info_Simple.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/24px-Info_Simple.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span></td> </tr> </tbody></table> <p>Le <b>rituximab</b> (commercialisé par les laboratoires <a href="/wiki/Roche_(entreprise)" title="Roche (entreprise)">Hoffmann-La Roche</a> et sa filiale <a href="/wiki/Genentech" title="Genentech">Genentech</a> sous les noms Rituxan et MabThera) est un <a href="/wiki/Anticorps_monoclonal" title="Anticorps monoclonal">anticorps monoclonal</a> chimérique dirigé contre la <a href="/wiki/Mol%C3%A9cule" title="Molécule">molécule</a> de surface <a href="/wiki/CD20" title="CD20">CD20</a> (présente sur la plupart des cellules B). Il permet de diminuer de façon substantielle le nombre de <a href="/wiki/Lymphocyte_B" title="Lymphocyte B">lymphocytes B</a> par un effet toxique direct sur ces cellules<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite_crochet">[</span>2<span class="cite_crochet">]</span></a></sup>, y compris lorsque ceux-ci prolifèrent lors d'un cancer de la moelle osseuse. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Utilisation">Utilisation</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Rituximab&veaction=edit&section=1" title="Modifier la section : Utilisation" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Rituximab&action=edit&section=1" title="Modifier le code source de la section : Utilisation"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>C'est un <a href="/wiki/M%C3%A9dicament" title="Médicament">médicament</a> utilisé dans le traitement de certains <a href="/wiki/Lymphome" title="Lymphome">lymphomes</a><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite_crochet">[</span>3<span class="cite_crochet">]</span></a></sup>, exprimant la molécule de surface CD20, c'est-à-dire la plupart des lymphomes B et la leucémie lymphoïde chronique. Ses principales indications sont les lymphomes diffus à grandes cellules B, les lymphomes folliculaires, les lymphomes du manteau et la leucémie lymphoïde chronique. Il est également actif dans la <a href="/wiki/Leuc%C3%A9mie_aigu%C3%AB_lymphoblastique" title="Leucémie aiguë lymphoblastique">leucémie aiguë lymphoblastique</a> dans les formes CD20<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite_crochet">[</span>4<span class="cite_crochet">]</span></a></sup>. </p><p>Il est également utilisé aujourd'hui pour traiter les formes sévères de certaines affections auto-immunes, en particulier les anémies hémolytiques, les purpuras thrombopéniques, le lupus, le pemphigus, et aussi la <a href="/wiki/Polyarthrite_rhumato%C3%AFde" title="Polyarthrite rhumatoïde">polyarthrite rhumatoïde</a>. Après une greffe de moelle ou d'organe il permet de traiter les lymphomes induits par le <a href="/wiki/Virus_d%27Epstein-Barr" title="Virus d'Epstein-Barr">virus EBV</a>. Enfin, il est également utilisé dans des formes particulières de rejet de greffes d'organes (rejet aigu vasculaire de mécanisme humoral). </p><p>Il est de plus en plus utilisé dans le traitement en seconde ligne de la <a href="/wiki/Myasthenia_gravis" class="mw-redirect" title="Myasthenia gravis">myasthénie</a> réfractaire ou résistante aux cortico-dépendante, après qu'une étude rétrospective a montré son efficacité<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite_crochet">[</span>5<span class="cite_crochet">]</span></a></sup>. </p><p>Ce médicament est en cours de test pour le traitement de la <a href="/wiki/Scl%C3%A9rose_en_plaques" title="Sclérose en plaques">sclérose en plaques</a><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite_crochet">[</span>6<span class="cite_crochet">]</span></a></sup> et a des résultats prometteurs lors d'une <a href="/wiki/Leuc%C3%A9mie_lympho%C3%AFde_chronique" title="Leucémie lymphoïde chronique">leucémie lymphoïde chronique</a><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite_crochet">[</span>7<span class="cite_crochet">]</span></a></sup>. </p><p>Son efficacité s'avère être décevante dans le <a href="/wiki/Lupus_%C3%A9ryth%C3%A9mateux_diss%C3%A9min%C3%A9" title="Lupus érythémateux disséminé">lupus érythémateux disséminé</a><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite_crochet">[</span>8<span class="cite_crochet">]</span></a></sup><sup class="reference cite_virgule">,</sup><sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite_crochet">[</span>9<span class="cite_crochet">]</span></a></sup>. </p><p>Dans les <a href="/wiki/Vascularite" title="Vascularite">vascularites</a> avec <a href="/wiki/Anticorps_antineutrophiles_cytoplasmatiques" class="mw-redirect" title="Anticorps antineutrophiles cytoplasmatiques">anticorps antineutrophiles cytoplasmatiques</a> (ANCA), le rituximab pourrait être une alternative au <a href="/wiki/Cyclophosphamide" title="Cyclophosphamide">cyclophosphamide</a><sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite_crochet">[</span>10<span class="cite_crochet">]</span></a></sup><sup class="reference cite_virgule">,</sup><sup id="cite_ref-specks2013_11-0" class="reference"><a href="#cite_note-specks2013-11"><span class="cite_crochet">[</span>11<span class="cite_crochet">]</span></a></sup>. Il pourrait avoir un intérêt dans le <a href="/wiki/Syndrome_de_Gougerot-Sj%C3%B6gren" title="Syndrome de Gougerot-Sjögren">syndrome de Gougerot-Sjögren</a><sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite_crochet">[</span>12<span class="cite_crochet">]</span></a></sup>. </p><p>Il est administré sous forme de <a href="/wiki/Perfusion_intraveineuse" title="Perfusion intraveineuse">perfusion par voie IV</a> lente ; le rythme dépend du type de pathologie à traiter. </p> <div class="mw-heading mw-heading2"><h2 id="Effets_secondaires">Effets secondaires</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Rituximab&veaction=edit&section=2" title="Modifier la section : Effets secondaires" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Rituximab&action=edit&section=2" title="Modifier le code source de la section : Effets secondaires"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Une <a href="/wiki/Urticaire" title="Urticaire">urticaire</a>, une fièvre, des frissons, peuvent se voir dans près de la moitié des cas après une injection de rituximab<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite_crochet">[</span>13<span class="cite_crochet">]</span></a></sup>. Ces effets indésirables sont le plus souvent bénins mais parfois sévères (<a href="/wiki/Maladie_s%C3%A9rique" title="Maladie sérique">maladie sérique</a>), dans 10 % des cas environ<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite_crochet">[</span>14<span class="cite_crochet">]</span></a></sup>. Ils tendent à s'estomper si on poursuit le traitement. Ils sont d'origine allergique et une <a href="/wiki/Hyposensibilisation" title="Hyposensibilisation">désensibilisation</a> peut en améliorer la tolérance<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite_crochet">[</span>15<span class="cite_crochet">]</span></a></sup>. </p><p>Rarement, une <a href="/wiki/Pneumopathie_interstitielle" class="mw-redirect" title="Pneumopathie interstitielle">pneumopathie interstitielle</a> peut survenir, d'évolution parfois fatale<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite_crochet">[</span>16<span class="cite_crochet">]</span></a></sup>. Une perforation intestinale a été décrite en cas de localisation digestive du lymphome<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite_crochet">[</span>17<span class="cite_crochet">]</span></a></sup>. Des cas de <a href="/wiki/Leucoenc%C3%A9phalopathie_multifocale_progressive" title="Leucoencéphalopathie multifocale progressive">leucoencéphalopathies multifocales progressives</a> ont été décrits<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite_crochet">[</span>18<span class="cite_crochet">]</span></a></sup>. </p><p>Du fait de son mécanisme d'action, il entraîne un certain degré d'<a href="/wiki/Immunod%C3%A9ficience" title="Immunodéficience">immunodéficience</a> ayant pour conséquence une plus grande sensibilité aux infections. Cette immunodéficience est relative puisque la fonction des <a href="/wiki/Lymphocyte_T" title="Lymphocyte T">lymphocytes T</a> est préservée. Des cas de <a href="/wiki/Neutrop%C3%A9nie" title="Neutropénie">neutropénies</a> retardées ont été décrits<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite_crochet">[</span>19<span class="cite_crochet">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Biosimilaire">Biosimilaire</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Rituximab&veaction=edit&section=3" title="Modifier la section : Biosimilaire" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Rituximab&action=edit&section=3" title="Modifier le code source de la section : Biosimilaire"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Le Truxima du laboratoire Biogaran est passé en <time class="nowrap" datetime="2017-04" data-sort-value="2017-04">avril 2017</time> à la commission de transparence de la HAS en France avec un avis favorable <sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite_crochet">[</span>20<span class="cite_crochet">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Autres_molécules_anti-CD20"><span id="Autres_mol.C3.A9cules_anti-CD20"></span>Autres molécules anti-CD20</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Rituximab&veaction=edit&section=4" title="Modifier la section : Autres molécules anti-CD20" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Rituximab&action=edit&section=4" title="Modifier le code source de la section : Autres molécules anti-CD20"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>L'<a href="/wiki/Ofatumumab" title="Ofatumumab">ofatumumab</a>, le <a href="/wiki/Tositumomab" title="Tositumomab">tositumomab</a>, l'<a href="/wiki/Obinutuzumab" title="Obinutuzumab">obinutuzumab</a> et l'<a href="/wiki/Ocrelizumab" class="mw-redirect" title="Ocrelizumab">ocrelizumab</a> sont d'autres anticorps monoclonaux se fixant sur une autre zone de la molécule <a href="/wiki/CD20" title="CD20">CD20</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Marché"><span id="March.C3.A9"></span>Marché</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Rituximab&veaction=edit&section=5" title="Modifier la section : Marché" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Rituximab&action=edit&section=5" title="Modifier le code source de la section : Marché"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Le rituximab serait la cinquième molécule médicamenteuse vendue, en termes de valeur, en 2012, avec un chiffre projeté de 7,1 milliards de dollars<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite_crochet">[</span>21<span class="cite_crochet">]</span></a></sup>. </p><p>Deux spécialités biosimilaires sont disponibles en France : la spécialité Rixathon commercialisée par le groupe <a href="/wiki/Sandoz" title="Sandoz">Sandoz</a> (filiale de <a href="/wiki/Novartis" title="Novartis">Novartis</a>) et la spécialité Truxima commercialisée par le groupe Celltrion Healthcare Hungary Kft représenté en France par <a href="/wiki/Biogaran" title="Biogaran">Biogaran</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Notes_et_références"><span id="Notes_et_r.C3.A9f.C3.A9rences"></span>Notes et références</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Rituximab&veaction=edit&section=6" title="Modifier la section : Notes et références" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Rituximab&action=edit&section=6" title="Modifier le code source de la section : Notes et références"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="references-small decimal" style="column-width:36em; column-count:2;"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink noprint"><a href="#cite_ref-1">↑</a> </span><span class="reference-text">Masse molaire calculée d’après <span class="ouvrage">« <a rel="nofollow" class="external text" href="http://www.chem.qmul.ac.uk/iupac/AtWt/"><cite style="font-style:normal;"><span class="lang-en" lang="en">Atomic weights of the elements 2007</span></cite></a> », sur <span class="italique">www.chem.qmul.ac.uk</span></span>.</span> </li> <li id="cite_note-2"><span class="mw-cite-backlink noprint"><a href="#cite_ref-2">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Reff ME, Carner K, Chambers KS <i><abbr class="abbr" title="et alii (« et d’autres »)" lang="la">et al.</abbr></i> <a rel="nofollow" class="external text" href="http://bloodjournal.hematologylibrary.org/cgi/content/abstract/83/2/435">« <span class="lang-en" lang="en">Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to</span> CD20 »</a> <i><a href="/wiki/Blood_(journal)" title="Blood (journal)"><span class="lang-en" lang="en">Blood</span></a></i>. 1994;83:435-445</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink noprint"><a href="#cite_ref-3">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Schulz H, Bohlius JF, Trelle S <i><abbr class="abbr" title="et alii (« et d’autres »)" lang="la">et al.</abbr></i> <a rel="nofollow" class="external text" href="http://jnci.oxfordjournals.org/content/99/9/706">« <span class="lang-en" lang="en">Immunochemotherapy with rituximab and overall survival in patients with indolent or mantle cell lymphoma: a systematic review and meta-analysis</span> »</a> <i><a href="/wiki/Journal_of_the_National_Cancer_Institute" title="Journal of the National Cancer Institute">J Natl Cancer Inst</a></i>. 2007; 99: 706-714</span> </li> <li id="cite_note-4"><span class="mw-cite-backlink noprint"><a href="#cite_ref-4">↑</a> </span><span class="reference-text">Maury S, Chevret S, Thomas X et al. <a rel="nofollow" class="external text" href="https://www.nejm.org/doi/10.1056/NEJMoa1605085"><i>Rituximab in B-lineage adult acute lymphoblastic leukemia</i></a>, N Engl J Med, 2016;375:1044-1053</span> </li> <li id="cite_note-5"><span class="mw-cite-backlink noprint"><a href="#cite_ref-5">↑</a> </span><span class="reference-text"><span class="ouvrage" id="2020">« <a rel="nofollow" class="external text" href="https://www.institut-myologie.org/2020/08/12/le-rituximab-fait-ses-preuves-en-vie-reelle-dans-la-myasthenie-refractaire-ou-cortico-dependante/"><cite style="font-style:normal;">Le rituximab fait ses preuves en vie réelle dans la myasthénie réfractaire ou cortico-dépendante</cite></a> », sur <span class="italique">www.institut-myologie.org/</span>, <time class="nowrap" datetime="2020-08-12" data-sort-value="2020-08-12">12 août 2020</time></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink noprint"><a href="#cite_ref-6">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Hauser SL, Waubant E, Arnold DL <i><abbr class="abbr" title="et alii (« et d’autres »)" lang="la">et al.</abbr></i> <a rel="nofollow" class="external text" href="http://content.nejm.org/cgi/content/abstract/358/7/676">« <span class="lang-en" lang="en">B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis</span> »</a> <i><a href="/wiki/The_New_England_Journal_of_Medicine" title="The New England Journal of Medicine">New Eng J Med</a></i>. 2008;358:676-688</span> </li> <li id="cite_note-7"><span class="mw-cite-backlink noprint"><a href="#cite_ref-7">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Hallek M, Fischer K, Fingerle-Rowson G <i><abbr class="abbr" title="et alii (« et d’autres »)" lang="la">et al.</abbr></i> <a rel="nofollow" class="external text" href="http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)61381-5/abstract">« <span class="lang-en" lang="en">Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial</span> »</a> <i><a href="/wiki/The_Lancet" title="The Lancet"><span class="lang-en" lang="en">Lancet</span></a></i> 2010;376:1164-1174</span> </li> <li id="cite_note-8"><span class="mw-cite-backlink noprint"><a href="#cite_ref-8">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Merrill JT, Neuwelt CM, Wallace DJ <i><abbr class="abbr" title="et alii (« et d’autres »)" lang="la">et al.</abbr></i> <a rel="nofollow" class="external text" href="http://onlinelibrary.wiley.com/doi/10.1002/art.27233/abstract">« <span class="lang-en" lang="en">Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase <abbr class="abbr" title="2"><span class="romain" style="text-transform:uppercase">II</span></abbr>/<abbr class="abbr" title="3"><span class="romain" style="text-transform:uppercase">III</span></abbr> systemic lupus erythematosus evaluation of rituximab trial</span> »</a> <i>Arthritis Rheum</i>. 2010;62:222-233</span> </li> <li id="cite_note-9"><span class="mw-cite-backlink noprint"><a href="#cite_ref-9">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Rovin BH, Furie R, Latinis K <i><abbr class="abbr" title="et alii (« et d’autres »)" lang="la">et al.</abbr></i> <a rel="nofollow" class="external text" href="http://onlinelibrary.wiley.com/doi/10.1002/art.34359/abstract">« <span class="lang-en" lang="en">Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study</span> »</a> <i>Arthritis Rheum.</i> 2012;64:1215-1226</span> </li> <li id="cite_note-10"><span class="mw-cite-backlink noprint"><a href="#cite_ref-10">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Stone JH, Merkel PA, Spiera R <i><abbr class="abbr" title="et alii (« et d’autres »)" lang="la">et al.</abbr></i> <a rel="nofollow" class="external text" href="http://www.nejm.org/doi/full/10.1056/NEJMoa0909905">« Rituximab <span class="lang-en" lang="en">versus cyclophosphamide for ANCA-associated vasculitis</span> »</a> <i><a href="/wiki/The_New_England_Journal_of_Medicine" title="The New England Journal of Medicine">N Engl J Med</a></i>. 2010;363:221-232</span> </li> <li id="cite_note-specks2013-11"><span class="mw-cite-backlink noprint"><a href="#cite_ref-specks2013_11-0">↑</a> </span><span class="reference-text"><span class="ouvrage" id="2013"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Specks U, Merkel PA, Seo P, Spiera R, Stone JH <i><abbr class="abbr" title="et alii (« et d’autres »)" lang="la">et al.</abbr></i> RAVE-ITN <span class="lang-en" lang="en">Research Group</span>, « <cite style="font-style:normal" lang="en">Efficacy of remission-induction regimens for ANCA-associated vasculitis</cite> », <i><a href="/wiki/The_New_England_Journal_of_Medicine" title="The New England Journal of Medicine"><span class="lang-en" lang="en">N Engl J Med</span></a></i>, <abbr class="abbr" title="volume">vol.</abbr> 369, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 5,‎ <time>2013</time>, <abbr class="abbr" title="page(s)">p.</abbr> 417-27. <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/23902481">23902481</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1056/NEJMoa1213277">10.1056/NEJMoa1213277</a></span>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Efficacy+of+remission-induction+regimens+for+ANCA-associated+vasculitis&rft.jtitle=N+Engl+J+Med&rft.issue=5&rft.date=2013&rft.volume=369&rft.pages=417-27.&rft_id=info%3Adoi%2F10.1056%2FNEJMoa1213277&rft_id=info%3Apmid%2F23902481&rfr_id=info%3Asid%2Ffr.wikipedia.org%3ARituximab"></span></span></span> </li> <li id="cite_note-12"><span class="mw-cite-backlink noprint"><a href="#cite_ref-12">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Meijer JM, Meiners PM, Vissink A <i><abbr class="abbr" title="et alii (« et d’autres »)" lang="la">et al.</abbr></i> <a rel="nofollow" class="external text" href="http://onlinelibrary.wiley.com/doi/10.1002/art.27314/abstract">« <span class="lang-en" lang="en">Effectiveness of rituximab treatment in primary Sjögren's syndrome: a randomized, double-blind, placebo-controlled trial</span> »</a> <i>Arthritis Rheum</i>. 2010;62:960-968</span> </li> <li id="cite_note-13"><span class="mw-cite-backlink noprint"><a href="#cite_ref-13">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Maloney DG, <a rel="nofollow" class="external text" href="http://www.nejm.org/doi/full/10.1056/NEJMct1114348#t=article">« Anti-CD20 antibody therapy for B-Cell lymphomas »</a> <i><a href="/wiki/The_New_England_Journal_of_Medicine" title="The New England Journal of Medicine">N Engl J Med</a></i>. 2012;366:2008-2016</span> </li> <li id="cite_note-14"><span class="mw-cite-backlink noprint"><a href="#cite_ref-14">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Plosker GL, Figgitt DP, <a rel="nofollow" class="external text" href="http://adisonline.com/drugs/pages/articleviewer.aspx?year=2003&issue=63080&article=00005&type=abstract">« Rituximab: a review of its use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemia »</a> <i>Drugs</i> 2003;63:803-843</span> </li> <li id="cite_note-15"><span class="mw-cite-backlink noprint"><a href="#cite_ref-15">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Brennan PJ, Rodriguez Bouza T, Hsu FI, Sloane DE, Castells MC, <a rel="nofollow" class="external text" href="http://www.sciencedirect.com/science/article/pii/S0091674909013384">« Hypersensitivity reactions to mAbs: 105 desensitizations in 23 patients, from evaluation to treatment »</a> <i>J Allergy Clin Immunol.</i> 2009;124:1259-1266</span> </li> <li id="cite_note-16"><span class="mw-cite-backlink noprint"><a href="#cite_ref-16">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Hadjinicolaou AV, Nisar MK, Parfrey H, Chivers ER, Ostor AJ, <a rel="nofollow" class="external text" href="http://rheumatology.oxfordjournals.org/content/51/4/653">« <span class="lang-en" lang="en">Non-infectious pulmonary toxicity of rituximab: a systematic review</span> »</a> <i><span class="lang-en" lang="en">Rheumatology (Oxford)</span></i>. 2012;51:653-662</span> </li> <li id="cite_note-17"><span class="mw-cite-backlink noprint"><a href="#cite_ref-17">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Kollmar O, Becker S, Schilling MK, Maurer CA. <span class="lang-en" lang="en">« Intestinal lymphoma perforations as a consequence of highly effective anti-CD20 antibody therapy » <i>Transplantation</i></span>. 2002;73:669-670</span> </li> <li id="cite_note-18"><span class="mw-cite-backlink noprint"><a href="#cite_ref-18">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Carson KR, Evens AM, Richey EA <i><abbr class="abbr" title="et alii (« et d’autres »)" lang="la">et al.</abbr></i> <a rel="nofollow" class="external text" href="http://bloodjournal.hematologylibrary.org/content/113/20/4834">« <span class="lang-en" lang="en">Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project</span> »</a> <i><a href="/wiki/Blood_(journal)" title="Blood (journal)"><span class="lang-en" lang="en">Blood</span></a></i>. 2009;113:4834-4840</span> </li> <li id="cite_note-19"><span class="mw-cite-backlink noprint"><a href="#cite_ref-19">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Wolach O, Bairey O, Lahav M, <a rel="nofollow" class="external text" href="http://journals.lww.com/md-journal/pages/articleviewer.aspx?year=2010&issue=09000&article=00005&type=abstract">« <span class="lang-en" lang="en">Late-onset neutropenia after rituximab treatment: case series and comprehensive review of the literature</span> »</a> <i><span class="lang-en" lang="en">Medicine (Baltimore)</span></i>. 2010;89:308-318</span> </li> <li id="cite_note-20"><span class="mw-cite-backlink noprint"><a href="#cite_ref-20">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : français">(fr)</abbr> <a rel="nofollow" class="external text" href="http://www.has-sante.fr/portail/jcms/c_2757876/fr/truxima">« <span class="lang-fr" lang="fr">évaluation & recommandation</span> »</a> <i><span class="lang-fr" lang="fr"><a href="/wiki/Haute_Autorit%C3%A9_de_Sant%C3%A9" class="mw-redirect" title="Haute Autorité de Santé">Haute Autorité de Santé</a></span></i>. </span> </li> <li id="cite_note-21"><span class="mw-cite-backlink noprint"><a href="#cite_ref-21">↑</a> </span><span class="reference-text"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <a rel="nofollow" class="external text" href="http://www.nature.com/nm/journal/v18/n5/full/nm0512-636a.html">« <span class="lang-en" lang="en">Biologic drugs set to top 2012 sales</span> »</a> <i><span class="lang-en" lang="en"><a href="/wiki/Nature_Medicine" title="Nature Medicine">Nature Medicine</a></span></i>. 2012;18,636</span> </li> </ol> </div> <div class="mw-heading mw-heading2"><h2 id="Voir_aussi">Voir aussi</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Rituximab&veaction=edit&section=7" title="Modifier la section : Voir aussi" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Rituximab&action=edit&section=7" title="Modifier le code source de la section : Voir aussi"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r194021218">.mw-parser-output .autres-projets>.titre{text-align:center;margin:0.2em 0}.mw-parser-output .autres-projets>ul{margin:0;padding:0}.mw-parser-output .autres-projets>ul>li{list-style:none;margin:0.2em 0;text-indent:0;padding-left:24px;min-height:20px;text-align:left;display:block}.mw-parser-output .autres-projets>ul>li>a{font-style:italic}@media(max-width:720px){.mw-parser-output .autres-projets{float:none}}</style><div class="autres-projets boite-grise boite-a-droite noprint js-interprojets"> <p class="titre">Sur les autres projets Wikimedia :</p> <ul class="noarchive plainlinks"> <li class="commons"><a class="external text" href="https://commons.wikimedia.org/wiki/Category:Rituximab?uselang=fr">Rituximab</a>, sur <span class="project">Wikimedia Commons</span></li> </ul> </div> <div class="mw-heading mw-heading3"><h3 id="Articles_connexes">Articles connexes</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Rituximab&veaction=edit&section=8" title="Modifier la section : Articles connexes" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Rituximab&action=edit&section=8" title="Modifier le code source de la section : Articles connexes"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Liste_d%27anticorps_monoclonaux" title="Liste d'anticorps monoclonaux">Liste d'anticorps monoclonaux</a></li></ul> <div class="mw-heading mw-heading3"><h3 id="Liens_externes">Liens externes</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Rituximab&veaction=edit&section=9" title="Modifier la section : Liens externes" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Rituximab&action=edit&section=9" title="Modifier le code source de la section : Liens externes"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Compendium suisse des médicaments : spécialités contenant <a rel="nofollow" class="external text" href="http://compendium.ch/search/all/Rituximab/startwith/fr">Rituximab</a></li></ul> <div class="navbox-container" style="clear:both;"> <table class="navbox collapsible noprint autocollapse" style=""> <tbody><tr><th class="navbox-title" colspan="2" style=""><div style="float:left; width:6em; text-align:left"><div class="noprint plainlinks nowrap tnavbar" style="padding:0; font-size:xx-small; color:var(--color-emphasized, #000000);"><a href="/wiki/Mod%C3%A8le:Palette_Agents_anticanc%C3%A9reux_intracellulaires" title="Modèle:Palette Agents anticancéreux intracellulaires"><abbr class="abbr" title="Voir ce modèle.">v</abbr></a> · <a class="external text" href="https://fr.wikipedia.org/w/index.php?title=Mod%C3%A8le:Palette_Agents_anticanc%C3%A9reux_intracellulaires&action=edit"><abbr class="abbr" title="Modifier ce modèle. Merci de prévisualiser avant de sauvegarder.">m</abbr></a></div></div><div style="font-size:110%">Agents anticancéreux intracellulaires / <a href="/wiki/Classe_ATC_L01" title="Classe ATC L01">ATC code L01</a></div></th> </tr> <tr> <th class="navbox-group" style="width:20em">Inhibiteur de la <a href="/wiki/R%C3%A9plication_de_l%27ADN" title="Réplication de l'ADN">réplication de l'ADN</a></th> <td class="navbox-list" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style=""><a href="/wiki/Agent_alkylant_antin%C3%A9oplasique" title="Agent alkylant antinéoplasique">Agents alkylants</a></th> <td class="navbox-list" style=";"><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style=""><a href="/wiki/Sel_de_platine" title="Sel de platine">Sels de platine</a></th> <td class="navbox-list" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/Carboplatine" title="Carboplatine">Carboplatine</a></li> <li><a href="/wiki/Cisplatine" title="Cisplatine">Cisplatine</a></li> <li><a href="/wiki/Oxaliplatine" title="Oxaliplatine">Oxaliplatine</a></li> <li><a href="/w/index.php?title=Dicycloplatine&action=edit&redlink=1" class="new" title="Dicycloplatine (page inexistante)">Dicycloplatine</a></li> <li><a href="/w/index.php?title=Nedaplatine&action=edit&redlink=1" class="new" title="Nedaplatine (page inexistante)">Nedaplatine</a></li> <li><a href="/w/index.php?title=Satraplatine&action=edit&redlink=1" class="new" title="Satraplatine (page inexistante)">Satraplatine</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style=""><a href="/wiki/Moutarde_azot%C3%A9e" title="Moutarde azotée">Moutardes azotées</a></th> <td class="navbox-list navbox-even" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/Bendamustine" title="Bendamustine">Bendamustine</a></li> <li><a href="/wiki/Chlorm%C3%A9thine" title="Chlorméthine">Chlorméthine</a></li> <li><a href="/wiki/Chlorambucil" title="Chlorambucil">Chlorambucil</a></li> <li><a href="/wiki/Cyclophosphamide" title="Cyclophosphamide">Cyclophosphamide</a></li> <li><a href="/wiki/Ifosfamide" title="Ifosfamide">Ifosfamide</a></li> <li><a href="/wiki/Melphalan" title="Melphalan">Melphalan</a></li> <li><a href="/wiki/Chlorm%C3%A9thine" title="Chlorméthine">Méchloréthamine</a></li> <li><a href="/wiki/T%C3%A9mozolomide" title="Témozolomide">Témozolomide</a></li> <li><a href="/wiki/Prednimustine" title="Prednimustine">Prednimustine</a></li> <li><a href="/wiki/Uramustine" title="Uramustine">Uramustine</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style=""><a href="/wiki/Nitrosour%C3%A9e" title="Nitrosourée">Nitrosourées</a></th> <td class="navbox-list" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/Carmustine" title="Carmustine">Carmustine</a></li> <li><a href="/wiki/Fot%C3%A9mustine" title="Fotémustine">Fotémustine</a></li> <li><a href="/wiki/Streptozotocine" title="Streptozotocine">Streptozotocine</a></li> <li><a href="/wiki/Lomustine" title="Lomustine">Lomustine</a></li> <li><a href="/w/index.php?title=Nimustine&action=edit&redlink=1" class="new" title="Nimustine (page inexistante)">Nimustine</a> <a href="https://en.wikipedia.org/wiki/Nimustine" class="extiw" title="en:Nimustine"><span class="indicateur-langue" title="Article en anglais : « Nimustine »">(en)</span></a></li> <li><a href="/w/index.php?title=Ranimustine&action=edit&redlink=1" class="new" title="Ranimustine (page inexistante)">Ranimustine</a> <a href="https://en.wikipedia.org/wiki/Ranimustine" class="extiw" title="en:Ranimustine"><span class="indicateur-langue" title="Article en anglais : « Ranimustine »">(en)</span></a></li> <li><a href="/wiki/Uramustine" title="Uramustine">Uramustine</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style=""><a href="/wiki/Sulfonate_d%27alkyle" title="Sulfonate d'alkyle">Sulfonates d'alkyle</a></th> <td class="navbox-list navbox-even" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/Busulfan" title="Busulfan">Busulfan</a> <ul><li><a href="/w/index.php?title=Mannosulfan&action=edit&redlink=1" class="new" title="Mannosulfan (page inexistante)">Mannosulfan</a></li> <li><a href="/wiki/Tr%C3%A9osulfan" title="Tréosulfan">Tréosulfan</a></li></ul></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style=""><a href="/wiki/Aziridine" title="Aziridine">Aziridines</a></th> <td class="navbox-list" style=";"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=Carboquone&action=edit&redlink=1" class="new" title="Carboquone (page inexistante)">Carboquone</a> <a href="https://en.wikipedia.org/wiki/Carboquone" class="extiw" title="en:Carboquone"><span class="indicateur-langue" title="Article en anglais : « Carboquone »">(en)</span></a></li> <li><a href="/w/index.php?title=Thiotepa&action=edit&redlink=1" class="new" title="Thiotepa (page inexistante)">Thiotepa</a> <a href="https://en.wikipedia.org/wiki/Thiotepa" class="extiw" title="en:Thiotepa"><span class="indicateur-langue" title="Article en anglais : « Thiotepa »">(en)</span></a></li> <li><a href="/w/index.php?title=Triaziquone&action=edit&redlink=1" class="new" title="Triaziquone (page inexistante)">Triaziquone</a> <a href="https://en.wikipedia.org/wiki/Triaziquone" class="extiw" title="en:Triaziquone"><span class="indicateur-langue" title="Article en anglais : « Triaziquone »">(en)</span></a></li> <li><a href="/w/index.php?title=Tri%C3%A9thylenemelamine&action=edit&redlink=1" class="new" title="Triéthylenemelamine (page inexistante)">Triéthylenemelamine</a> <a href="https://en.wikipedia.org/wiki/Triethylenemelamine" class="extiw" title="en:Triethylenemelamine"><span class="indicateur-langue" title="Article en anglais : « Triethylenemelamine »">(en)</span></a></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style=""><a href="/wiki/Antim%C3%A9tabolite" title="Antimétabolite">Antimétabolites</a></th> <td class="navbox-list navbox-even" style=";"><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="">Inhibiteur de la <a href="/wiki/Dihydrofolate_r%C3%A9ductase" title="Dihydrofolate réductase">dihydrofolate réductase</a></th> <td class="navbox-list" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/M%C3%A9thotrexate" title="Méthotrexate">Méthotrexate</a></li> <li><a href="/wiki/Aminopt%C3%A9rine" title="Aminoptérine">Aminoptérine</a></li> <li><a href="/wiki/P%C3%A9m%C3%A9trexed" title="Pémétrexed">Pémétrexed</a></li> <li><a href="/w/index.php?title=Pralatrexate&action=edit&redlink=1" class="new" title="Pralatrexate (page inexistante)">Pralatrexate</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="">Inhibiteur de la <a href="/wiki/Thymidylate_synthase" title="Thymidylate synthase">Thymidylate synthase</a></th> <td class="navbox-list navbox-even" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/Fluorouracile" title="Fluorouracile">Fluorouracile</a></li> <li><a href="/wiki/P%C3%A9m%C3%A9trexed" title="Pémétrexed">Pémétrexed</a></li> <li><a href="/w/index.php?title=Raltitrexed&action=edit&redlink=1" class="new" title="Raltitrexed (page inexistante)">Raltitrexed</a></li> <li><a href="/wiki/Cap%C3%A9citabine" title="Capécitabine">Capécitabine</a></li> <li><a href="/w/index.php?title=Carmofur&action=edit&redlink=1" class="new" title="Carmofur (page inexistante)">Carmofur</a></li> <li><a href="/w/index.php?title=Doxifluridine&action=edit&redlink=1" class="new" title="Doxifluridine (page inexistante)">Doxifluridine</a></li> <li><a href="/wiki/Floxuridine" title="Floxuridine">Floxuridine</a></li> <li><a href="/wiki/T%C3%A9gafur" title="Tégafur">Tegafur</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="">Inhibiteur de la <a href="/wiki/Ribonucl%C3%A9otide_r%C3%A9ductase" title="Ribonucléotide réductase">RNR</a></th> <td class="navbox-list" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/Cladribine" title="Cladribine">Cladribine</a></li> <li><a href="/wiki/Clofarabine" title="Clofarabine">Clofarabine</a></li> <li><a href="/wiki/Fludarabine" title="Fludarabine">Fludarabine</a></li> <li><a href="/wiki/N%C3%A9larabine" title="Nélarabine">Nélarabine</a></li> <li><a href="/wiki/Gemcitabine" title="Gemcitabine">Gemcitabine</a></li> <li><a href="/wiki/Hydroxyur%C3%A9e" title="Hydroxyurée">Hydroxyurée</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="">Inhibiteur de <a href="/wiki/R%C3%A9action_en_cha%C3%AEne_par_polym%C3%A9rase" title="Réaction en chaîne par polymérase">PCR</a></th> <td class="navbox-list navbox-even" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/Cytarabine" title="Cytarabine">Cytarabine</a></li> <li><a href="/wiki/Daunorubicine" title="Daunorubicine">Daunorubicine</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="">Inhibiteur de <a href="/wiki/M%C3%A9thylation" title="Méthylation">méthylation</a></th> <td class="navbox-list" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/Azacitidine" title="Azacitidine">Azacitidine</a></li> <li><a href="/wiki/D%C3%A9citabine" title="Décitabine">Décitabine</a></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style=""><a href="/wiki/Inhibiteur_de_topoisom%C3%A9rase" title="Inhibiteur de topoisomérase">Inhibiteurs de topoisomérase</a></th> <td class="navbox-list" style=";"><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="">I</th> <td class="navbox-list" style=";"><div class="liste-horizontale"> <ul><li><i><a href="/w/index.php?title=Camptotheca&action=edit&redlink=1" class="new" title="Camptotheca (page inexistante)">Camptotheca</a> <a href="https://en.wikipedia.org/wiki/Camptotheca" class="extiw" title="en:Camptotheca"><span class="indicateur-langue" title="Article en anglais : « Camptotheca »">(en)</span></a></i> <ul><li><a href="/wiki/Irinot%C3%A9can" title="Irinotécan">Irinotécan</a></li> <li><a href="/wiki/Topot%C3%A9can" title="Topotécan">Topotécan</a></li></ul></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="">II</th> <td class="navbox-list navbox-even" style=";"><div class="liste-horizontale"> <ul><li><i><a href="/wiki/Podophyllum" title="Podophyllum">Podophyllum</a></i> <ul><li><a href="/wiki/%C3%89toposide" title="Étoposide">Étoposide</a></li> <li><a href="/wiki/T%C3%A9niposide" title="Téniposide">Téniposide</a></li></ul></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="">II + <a href="/wiki/Intercalation_(biochimie)" title="Intercalation (biochimie)">Intercalation</a></th> <td class="navbox-list" style=";"><div class="liste-horizontale"> <ul><li><i><a href="/w/index.php?title=Antibiotique_antitumoral&action=edit&redlink=1" class="new" title="Antibiotique antitumoral (page inexistante)">Antibiotiques antitumoraux</a></i> <ul><li><a href="/wiki/Bl%C3%A9omycine" title="Bléomycine">Bléomycine</a></li> <li><a href="/wiki/Daunorubicine" title="Daunorubicine">Daunorubicine</a></li> <li><a href="/wiki/Doxorubicine" title="Doxorubicine">Doxorubicine</a></li> <li><a href="/wiki/%C3%89pirubicine" title="Épirubicine">Épirubicine</a></li> <li><a href="/wiki/Hydroxyur%C3%A9e" title="Hydroxyurée">Hydroxyurée</a></li> <li><a href="/wiki/Idarubicine" title="Idarubicine">Idarubicine</a></li> <li><a href="/wiki/Mitomycine_C" title="Mitomycine C">Mitomycine C</a></li> <li><a href="/wiki/Mitoxantrone" title="Mitoxantrone">Mitoxantrone</a></li></ul></li></ul> </div></td> </tr> </tbody></table></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style="width:20em">Poisons du <a href="/wiki/Fuseau_mitotique" title="Fuseau mitotique">fuseau mitotique</a> (<a href="/wiki/Antimitotique" title="Antimitotique">antimitotiques</a>)</th> <td class="navbox-list navbox-even" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="">Bloqueur de l'assemblage des <a href="/wiki/Microtubule" title="Microtubule">microtubules</a></th> <td class="navbox-list" style=";"><div class="liste-horizontale"> <ul><li><i><a href="/wiki/Alcalo%C3%AFde" title="Alcaloïde">Alcaloïdes végétaux</a></i> <ul><li><a href="/wiki/Vinblastine" title="Vinblastine">Vinblastine</a></li> <li><a href="/wiki/Vincristine" title="Vincristine">Vincristine</a></li> <li><a href="/wiki/Vinorelbine" title="Vinorelbine">Vinorelbine</a></li> <li><a href="/wiki/Vind%C3%A9sine" title="Vindésine">Vindésine</a></li> <li><a href="/w/index.php?title=Vinflunine&action=edit&redlink=1" class="new" title="Vinflunine (page inexistante)">Vinflunine</a></li></ul></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="">Bloqueur du désassemblage des <a href="/wiki/Microtubule" title="Microtubule">microtubules</a></th> <td class="navbox-list navbox-even" style=";"><div class="liste-horizontale"> <ul><li><i><a href="/wiki/Taxane" title="Taxane">Taxanes</a></i> <ul><li><a href="/wiki/Doc%C3%A9taxel" title="Docétaxel">Docétaxel</a></li> <li><a href="/wiki/Paclitaxel" title="Paclitaxel">Paclitaxel</a></li> <li><a href="/wiki/Cabazitaxel" title="Cabazitaxel">Cabazitaxel</a></li> <li><a href="/w/index.php?title=Larotaxel&action=edit&redlink=1" class="new" title="Larotaxel (page inexistante)">Larotaxel</a></li> <li><a href="/w/index.php?title=Tesetaxel&action=edit&redlink=1" class="new" title="Tesetaxel (page inexistante)">Tesetaxel</a></li></ul></li> <li><i><a href="/wiki/%C3%89pothilone" title="Épothilone">Épothilones</a></i> <ul><li><a href="/w/index.php?title=Ixabepilone&action=edit&redlink=1" class="new" title="Ixabepilone (page inexistante)">Ixabepilone</a></li></ul></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style="width:20em"><a href="/wiki/Th%C3%A9rapie_photodynamique" title="Thérapie photodynamique">Thérapie photodynamique</a></th> <td class="navbox-list" style=""><div class="liste-horizontale"> <ul><li><a href="/wiki/Acide_%CE%B4-aminol%C3%A9vulinique" title="Acide δ-aminolévulinique">Acide δ-aminolévulinique</a></li> <li><a href="/w/index.php?title=%C3%89faproxiral&action=edit&redlink=1" class="new" title="Éfaproxiral (page inexistante)">Éfaproxiral</a></li> <li><a href="/w/index.php?title=Aminol%C3%A9vulinate_de_m%C3%A9thyle&action=edit&redlink=1" class="new" title="Aminolévulinate de méthyle (page inexistante)">Aminolévulinate de méthyle</a></li> <li><i><a href="/wiki/Porphyrine" title="Porphyrine">Porphyrines</a></i> <ul><li><a href="/w/index.php?title=Porfim%C3%A8re_sodique&action=edit&redlink=1" class="new" title="Porfimère sodique (page inexistante)">Porfimère sodique</a></li> <li><a href="/w/index.php?title=Padeliporfine&action=edit&redlink=1" class="new" title="Padeliporfine (page inexistante)">Padeliporfine</a></li> <li><a href="/w/index.php?title=Talaporfine&action=edit&redlink=1" class="new" title="Talaporfine (page inexistante)">Talaporfine</a></li> <li><a href="/w/index.php?title=Temoporfine&action=edit&redlink=1" class="new" title="Temoporfine (page inexistante)">Temoporfine</a></li> <li><a href="/w/index.php?title=Verteporfine&action=edit&redlink=1" class="new" title="Verteporfine (page inexistante)">Verteporfine</a></li></ul></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="width:20em"><a href="/wiki/Inhibiteur_de_kinase" title="Inhibiteur de kinase">Inhibiteurs de protéine kinase</a></th> <td class="navbox-list navbox-even" style=""><div class="liste-horizontale"> <ul><li><a href="/wiki/Imatinib" title="Imatinib">Imatinib</a></li> <li><a href="/wiki/G%C3%A9fitinib" title="Géfitinib">Géfitinib</a></li> <li><a href="/wiki/Erlotinib" title="Erlotinib">Erlotinib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Soraf%C3%A9nib" title="Sorafénib">Sorafénib</a></li> <li><a href="/wiki/Dasatinib" title="Dasatinib">Dasatinib</a></li> <li><a href="/w/index.php?title=Lapatinib&action=edit&redlink=1" class="new" title="Lapatinib (page inexistante)">Lapatinib</a></li> <li><a href="/wiki/Nilotinib" title="Nilotinib">Nilotinib</a></li> <li><a href="/wiki/Temsirolimus" title="Temsirolimus">Temsirolimus</a></li> <li><a href="/wiki/%C3%89v%C3%A9rolimus" title="Évérolimus">Évérolimus</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Vand%C3%A9tanib" title="Vandétanib">Vandétanib</a></li> <li><a href="/wiki/Afatinib" title="Afatinib">Afatinib</a></li> <li><a href="/wiki/Bosutinib" title="Bosutinib">Bosutinib</a></li> <li><a href="/wiki/Vemurafenib" title="Vemurafenib">Vemurafenib</a></li> <li><a href="/wiki/Crizotinib" title="Crizotinib">Crizotinib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Ruxolitinib" title="Ruxolitinib">Ruxolitinib</a></li> <li><a href="/w/index.php?title=Ridaforolimus&action=edit&redlink=1" class="new" title="Ridaforolimus (page inexistante)">Ridaforolimus</a></li> <li><a href="/wiki/R%C3%A9goraf%C3%A9nib" title="Régorafénib">Régorafénib</a></li> <li><a href="/wiki/Masitinib" title="Masitinib">Masitinib</a></li> <li><a href="/wiki/Dabrafenib" title="Dabrafenib">Dabrafénib</a></li> <li><a href="/wiki/Ponatinib" title="Ponatinib">Ponatinib</a></li> <li><a href="/wiki/Trametinib" title="Trametinib">Tramétinib</a></li> <li><a href="/wiki/Cabozantinib" title="Cabozantinib">Cabozantinib</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="width:20em">Autres</th> <td class="navbox-list" style=""><div class="liste-horizontale"> <ul><li><a href="/wiki/Aflibercept" title="Aflibercept">Aflibercept</a></li> <li><a href="/wiki/Anhydride_ars%C3%A9nieux" title="Anhydride arsénieux">Anhydride arsénieux</a></li> <li><i><a href="/wiki/Asparagine" 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href="/w/index.php?title=Denileukin_diftitox&action=edit&redlink=1" class="new" title="Denileukin diftitox (page inexistante)">Denileukin diftitox</a></li> <li><a href="/w/index.php?title=Elesclomol&action=edit&redlink=1" class="new" title="Elesclomol (page inexistante)">Elesclomol</a></li> <li><a href="/w/index.php?title=Elsamitrucin&action=edit&redlink=1" class="new" title="Elsamitrucin (page inexistante)">Elsamitrucin</a></li> <li><a href="/wiki/%C3%89nasid%C3%A9nib" title="Énasidénib">Énasidénib</a></li> <li><a href="/w/index.php?title=Epacadostat&action=edit&redlink=1" class="new" title="Epacadostat (page inexistante)">Epacadostat</a></li> <li><a href="/wiki/%C3%89ribuline" title="Éribuline">Éribuline</a></li> <li><a href="/w/index.php?title=Estramustine_phosphate&action=edit&redlink=1" class="new" title="Estramustine phosphate (page inexistante)">Estramustine phosphate</a></li> <li><a href="/wiki/Ivosid%C3%A9nib" title="Ivosidénib">Ivosidénib</a></li> <li><a href="/w/index.php?title=Lonidamine&action=edit&redlink=1" class="new" title="Lonidamine (page inexistante)">Lonidamine</a></li> <li><a href="/w/index.php?title=Lucanthone&action=edit&redlink=1" class="new" title="Lucanthone (page inexistante)">Lucanthone</a></li> <li><a href="/w/index.php?title=Lurbinectedine&action=edit&redlink=1" class="new" title="Lurbinectedine (page inexistante)">Lurbinectedine</a></li> <li><a href="/w/index.php?title=Mitoguazone&action=edit&redlink=1" class="new" title="Mitoguazone (page inexistante)">Mitoguazone</a></li> <li><a href="/wiki/Dichlorodiph%C3%A9nyldichloro%C3%A9thane" title="Dichlorodiphényldichloroéthane">Mitotane</a></li> <li><a href="/w/index.php?title=Oblimersen&action=edit&redlink=1" class="new" title="Oblimersen (page inexistante)">Oblimersen</a></li> <li><a href="/w/index.php?title=Omacetaxine_mepesuccinate&action=edit&redlink=1" class="new" title="Omacetaxine mepesuccinate (page inexistante)">Omacetaxine mepesuccinate</a></li> <li><a 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href="/w/index.php?title=Talimogene_laherparepvec&action=edit&redlink=1" class="new" title="Talimogene laherparepvec (page inexistante)">Talimogene laherparepvec</a></li> <li><a href="/w/index.php?title=Tazemetostat&action=edit&redlink=1" class="new" title="Tazemetostat (page inexistante)">Tazemetostat</a></li> <li><a href="/wiki/Tiazofurine" title="Tiazofurine">Tiazofurine</a></li> <li><a href="/w/index.php?title=Tigilanol_tiglate&action=edit&redlink=1" class="new" title="Tigilanol tiglate (page inexistante)">Tigilanol tiglate</a></li> <li><a href="/wiki/Tisagenlecleucel" title="Tisagenlecleucel">Tisagenlecleucel</a></li> <li><a href="/wiki/Trabect%C3%A9dine" title="Trabectédine">Trabectédine</a></li> <li><a href="/w/index.php?title=Veliparib&action=edit&redlink=1" class="new" title="Veliparib (page inexistante)">Veliparib</a></li> <li><a href="/wiki/V%C3%A9n%C3%A9toclax" title="Vénétoclax">Vénétoclax</a></li> <li><a href="/w/index.php?title=Verdinexor&action=edit&redlink=1" 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