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href="https://www.academia.edu/Documents/in/Mitochondrial_DNA">Mitochondrial DNA</a><script data-card-contents-for-ri="63093" type="text/json">{"id":63093,"name":"Mitochondrial DNA","url":"https://www.academia.edu/Documents/in/Mitochondrial_DNA?f_ri=86952","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=3844143]'), work: {"id":3844143,"title":"An mtDNA perspective of French genetic variation","created_at":"2013-07-02T23:41:08.929-07:00","url":"https://www.academia.edu/3844143/An_mtDNA_perspective_of_French_genetic_variation?f_ri=86952","dom_id":"work_3844143","summary":null,"downloadable_attachments":[{"id":50117439,"asset_id":3844143,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":4730935,"first_name":"Kristiina","last_name":"Tambets","domain_name":"ebc","page_name":"KristiinaTambets","display_name":"Kristiina Tambets","profile_url":"https://ebc.academia.edu/KristiinaTambets?f_ri=86952","photo":"https://0.academia-photos.com/4730935/2001822/2362182/s65_kristiina.tambets.jpg"}],"research_interests":[{"id":4480,"name":"Population Genetics","url":"https://www.academia.edu/Documents/in/Population_Genetics?f_ri=86952","nofollow":false},{"id":27336,"name":"France","url":"https://www.academia.edu/Documents/in/France?f_ri=86952","nofollow":false},{"id":54433,"name":"Phylogeny","url":"https://www.academia.edu/Documents/in/Phylogeny?f_ri=86952","nofollow":false},{"id":63093,"name":"Mitochondrial DNA","url":"https://www.academia.edu/Documents/in/Mitochondrial_DNA?f_ri=86952","nofollow":false},{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=86952"},{"id":577933,"name":"Genetic variation","url":"https://www.academia.edu/Documents/in/Genetic_variation?f_ri=86952"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology?f_ri=86952"},{"id":1934791,"name":"Gene pool","url":"https://www.academia.edu/Documents/in/Gene_pool?f_ri=86952"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_19310794" data-work_id="19310794" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/19310794/An_ancient_icon_reveals_new_mysteries_mummy_DNA_resurrects_a_cryptic_species_within_the_Nile_crocodile">An ancient icon reveals new mysteries: mummy DNA resurrects a cryptic species within the Nile crocodile</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a 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Amato","profile_url":"https://independent.academia.edu/GeorgeAmato?f_ri=86952","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":130,"name":"Ancient History","url":"https://www.academia.edu/Documents/in/Ancient_History?f_ri=86952","nofollow":false},{"id":4206,"name":"Phylogeography","url":"https://www.academia.edu/Documents/in/Phylogeography?f_ri=86952","nofollow":false},{"id":4527,"name":"Africa","url":"https://www.academia.edu/Documents/in/Africa?f_ri=86952","nofollow":false},{"id":4967,"name":"Molecular Evolution","url":"https://www.academia.edu/Documents/in/Molecular_Evolution?f_ri=86952","nofollow":false},{"id":12537,"name":"Egypt","url":"https://www.academia.edu/Documents/in/Egypt?f_ri=86952"},{"id":46119,"name":"Molecular Ecology","url":"https://www.academia.edu/Documents/in/Molecular_Ecology?f_ri=86952"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=86952"},{"id":48057,"name":"DNA","url":"https://www.academia.edu/Documents/in/DNA?f_ri=86952"},{"id":50157,"name":"Molecular","url":"https://www.academia.edu/Documents/in/Molecular?f_ri=86952"},{"id":67484,"name":"Sequence alignment","url":"https://www.academia.edu/Documents/in/Sequence_alignment?f_ri=86952"},{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=86952"},{"id":128357,"name":"Mummies","url":"https://www.academia.edu/Documents/in/Mummies?f_ri=86952"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_5802062" data-work_id="5802062" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/5802062/Two_newly_identified_genetic_determinants_of_pigmentation_in_Europeans">Two newly identified genetic determinants of pigmentation in Europeans</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5802062" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5af012090be3ebbc94180620755fd272" rel="nofollow" data-download="{"attachment_id":49134119,"asset_id":5802062,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49134119/download_file?st=MTczMjc4NTIwNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="4820392" href="https://independent.academia.edu/Sn%C3%A6bj%C3%B6rnP%C3%A1lsson">Snæbjörn Pálsson</a><script data-card-contents-for-user="4820392" type="text/json">{"id":4820392,"first_name":"Snæbjörn","last_name":"Pálsson","domain_name":"independent","page_name":"SnæbjörnPálsson","display_name":"Snæbjörn Pálsson","profile_url":"https://independent.academia.edu/Sn%C3%A6bj%C3%B6rnP%C3%A1lsson?f_ri=86952","photo":"https://0.academia-photos.com/4820392/2058152/2423389/s65_sn_bj_rn.p_lsson.jpg"}</script></span></span></li><li class="js-paper-rank-work_5802062 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="5802062"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 5802062, container: ".js-paper-rank-work_5802062", }); });</script></li><li class="js-percentile-work_5802062 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 5802062; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var 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style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="5802062"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="156" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1877" href="https://www.academia.edu/Documents/in/Pigmentation">Pigmentation</a>, <script data-card-contents-for-ri="1877" type="text/json">{"id":1877,"name":"Pigmentation","url":"https://www.academia.edu/Documents/in/Pigmentation?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4480" href="https://www.academia.edu/Documents/in/Population_Genetics">Population Genetics</a>, <script data-card-contents-for-ri="4480" type="text/json">{"id":4480,"name":"Population Genetics","url":"https://www.academia.edu/Documents/in/Population_Genetics?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="45716" href="https://www.academia.edu/Documents/in/Iceland">Iceland</a><script data-card-contents-for-ri="45716" type="text/json">{"id":45716,"name":"Iceland","url":"https://www.academia.edu/Documents/in/Iceland?f_ri=86952","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=5802062]'), work: {"id":5802062,"title":"Two newly identified genetic determinants of pigmentation in 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Genetics","url":"https://www.academia.edu/Documents/in/Population_Genetics?f_ri=86952","nofollow":false},{"id":45716,"name":"Iceland","url":"https://www.academia.edu/Documents/in/Iceland?f_ri=86952","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=86952"},{"id":52739,"name":"Association study","url":"https://www.academia.edu/Documents/in/Association_study?f_ri=86952"},{"id":83996,"name":"Hair","url":"https://www.academia.edu/Documents/in/Hair?f_ri=86952"},{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=86952"},{"id":99271,"name":"Calcium channels","url":"https://www.academia.edu/Documents/in/Calcium_channels?f_ri=86952"},{"id":157892,"name":"Netherlands","url":"https://www.academia.edu/Documents/in/Netherlands?f_ri=86952"},{"id":224794,"name":"Genetic linkage analysis","url":"https://www.academia.edu/Documents/in/Genetic_linkage_analysis?f_ri=86952"},{"id":309434,"name":"Solar System","url":"https://www.academia.edu/Documents/in/Solar_System?f_ri=86952"},{"id":437772,"name":"Odds ratio","url":"https://www.academia.edu/Documents/in/Odds_ratio?f_ri=86952"},{"id":1211562,"name":"Melanosis","url":"https://www.academia.edu/Documents/in/Melanosis?f_ri=86952"},{"id":1235646,"name":"Eye Color","url":"https://www.academia.edu/Documents/in/Eye_Color?f_ri=86952"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_79635037 coauthored" data-work_id="79635037" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/79635037/Mitochondrial_DNA_analysis_of_field_populations_of_Helicoverpa_armigera_Lepidoptera_Noctuidae_and_of_its_relationship_to_H_zea">Mitochondrial DNA analysis of field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) and of its relationship to H. zea</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background Helicoverpa armigera and H. zea are amongst the most significant polyphagous pest lepidopteran species in the Old and New Worlds respectively. Separation of H. armigera and H. zea is difficult and is usually only achieved... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_79635037" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background Helicoverpa armigera and H. zea are amongst the most significant polyphagous pest lepidopteran species in the Old and New Worlds respectively. Separation of H. armigera and H. zea is difficult and is usually only achieved through morphological differences in the genitalia. They are capable of interbreeding to produce fertile offspring. The single species status of H. armigera has been doubted, due to its wide distribution and plant host range across the Old World. This study explores the global genetic diversity of H. armigera and its evolutionary relationship to H zea. Results We obtained partial (511 bp) mitochondrial DNA (mtDNA) Cytochrome Oxidase-I (COI) sequences for 249 individuals of H. armigera sampled from Australia, Burkina Faso, Uganda, China, India and Pakistan which were associated with various host plants. Single nucleotide polymorphisms (SNPs) within the partial COI gene differentiated H. armigera populations into 33 mtDNA haplotypes. Shared haplotypes betw...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/79635037" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5d585774a147cd045ba7f3215dcfb8dc" rel="nofollow" data-download="{"attachment_id":86282460,"asset_id":79635037,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/86282460/download_file?st=MTczMjc4NTIwNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="3309909" href="https://independent.academia.edu/GaneshBehere">Ganesh Behere</a><script data-card-contents-for-user="3309909" type="text/json">{"id":3309909,"first_name":"Ganesh","last_name":"Behere","domain_name":"independent","page_name":"GaneshBehere","display_name":"Ganesh Behere","profile_url":"https://independent.academia.edu/GaneshBehere?f_ri=86952","photo":"https://0.academia-photos.com/3309909/1103537/1376103/s65_ganesh.behere.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-79635037">+1</span><div class="hidden js-additional-users-79635037"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/DerekRussell12">Derek Russell</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-79635037'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-79635037').html(); 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Separation of H. armigera and H. zea is difficult and is usually only achieved through morphological differences in the genitalia. They are capable of interbreeding to produce fertile offspring. The single species status of H. armigera has been doubted, due to its wide distribution and plant host range across the Old World. This study explores the global genetic diversity of H. armigera and its evolutionary relationship to H zea. Results We obtained partial (511 bp) mitochondrial DNA (mtDNA) Cytochrome Oxidase-I (COI) sequences for 249 individuals of H. armigera sampled from Australia, Burkina Faso, Uganda, China, India and Pakistan which were associated with various host plants. Single nucleotide polymorphisms (SNPs) within the partial COI gene differentiated H. armigera populations into 33 mtDNA haplotypes. Shared haplotypes betw...","downloadable_attachments":[{"id":86282460,"asset_id":79635037,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":3309909,"first_name":"Ganesh","last_name":"Behere","domain_name":"independent","page_name":"GaneshBehere","display_name":"Ganesh Behere","profile_url":"https://independent.academia.edu/GaneshBehere?f_ri=86952","photo":"https://0.academia-photos.com/3309909/1103537/1376103/s65_ganesh.behere.jpg"},{"id":225259441,"first_name":"Derek","last_name":"Russell","domain_name":"independent","page_name":"DerekRussell12","display_name":"Derek Russell","profile_url":"https://independent.academia.edu/DerekRussell12?f_ri=86952","photo":"https://0.academia-photos.com/225259441/82454975/71061246/s65_derek.russell.png"}],"research_interests":[{"id":155,"name":"Evolutionary 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addiction</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/29638783" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="926cda5b10e4068b9da3ff46324005b2" rel="nofollow" data-download="{"attachment_id":50076616,"asset_id":29638783,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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addiction","created_at":"2016-11-03T04:08:11.194-07:00","url":"https://www.academia.edu/29638783/The_fatty_acid_amide_hydrolase_385_A_A_P129T_variant_haplotype_analysis_of_an_ancient_missense_mutation_and_validation_of_risk_for_drug_addiction?f_ri=86952","dom_id":"work_29638783","summary":null,"downloadable_attachments":[{"id":50076616,"asset_id":29638783,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":27408021,"first_name":"Alexandra","last_name":"Gerber","domain_name":"independent","page_name":"AlexandraGerber","display_name":"Alexandra Gerber","profile_url":"https://independent.academia.edu/AlexandraGerber?f_ri=86952","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=86952","nofollow":false},{"id":772,"name":"Human Evolution","url":"https://www.academia.edu/Documents/in/Human_Evolution?f_ri=86952","nofollow":false},{"id":1135,"name":"Human 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Size","url":"https://www.academia.edu/Documents/in/Sample_Size?f_ri=86952"},{"id":209189,"name":"Drug abuse","url":"https://www.academia.edu/Documents/in/Drug_abuse?f_ri=86952"},{"id":212320,"name":"Logistic Regression Analysis","url":"https://www.academia.edu/Documents/in/Logistic_Regression_Analysis?f_ri=86952"},{"id":233800,"name":"African Americans","url":"https://www.academia.edu/Documents/in/African_Americans?f_ri=86952"},{"id":349286,"name":"Asian Americans","url":"https://www.academia.edu/Documents/in/Asian_Americans?f_ri=86952"},{"id":372410,"name":"Genotype","url":"https://www.academia.edu/Documents/in/Genotype?f_ri=86952"},{"id":403740,"name":"Single Nucleotide Polymorphism","url":"https://www.academia.edu/Documents/in/Single_Nucleotide_Polymorphism?f_ri=86952"},{"id":489736,"name":"Linkage Disequilibrium","url":"https://www.academia.edu/Documents/in/Linkage_Disequilibrium?f_ri=86952"},{"id":561981,"name":"European Continental Ancestry 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u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_7882200" data-work_id="7882200" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/7882200/Amyloid_Precursor_Protein_Gene_APP_Variation_in_Late_Onset_Alzheimer_s_Disease">Amyloid Precursor Protein Gene ( APP ) Variation in Late-Onset Alzheimer’s Disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Mutations in the beta-amyloid precursor protein gene (APP) have been found in familial early-onset Alzheímer’s disease (AD). DNA variants at several genes have been linked to the risk of developing the most common late-onset form of AD... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_7882200" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Mutations in the beta-amyloid precursor protein gene (APP) have been found in familial early-onset Alzheímer’s disease (AD). DNA variants at several genes have been linked to the risk of developing the most common late-onset form of AD (LOAD). A few studies analyzed the contribution of APP variants to LOAD, with negative or conflicting results. We determined the variation in the 18 APP exons and flanking intronic sequences in a total of 350 LOAD patients from Spain. A total of 13 nucleotide changes were found and 6 were new and not found among 340 healthy controls, including the only missense change (D243N). The in silico analysis suggested that none of them would have an effect on pre-mRNA splicing or protein folding (D243N). Patients and controls were also genotyped for three APP promoter polymorphisms, and none of them was significantly associated with LOAD. We concluded that APP variants would not contribute to the risk of developing LOAD in our population.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/7882200" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="37c698b980651f3ccf0a432d784d5891" rel="nofollow" data-download="{"attachment_id":48303750,"asset_id":7882200,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48303750/download_file?st=MTczMjc4NTIwNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="14731222" href="https://independent.academia.edu/MirnaDiaz">Mirna Diaz</a><script data-card-contents-for-user="14731222" type="text/json">{"id":14731222,"first_name":"Mirna","last_name":"Diaz","domain_name":"independent","page_name":"MirnaDiaz","display_name":"Mirna Diaz","profile_url":"https://independent.academia.edu/MirnaDiaz?f_ri=86952","photo":"https://0.academia-photos.com/14731222/4012647/4685162/s65_mirna.diaz.jpg"}</script></span></span></li><li class="js-paper-rank-work_7882200 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="7882200"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 7882200, container: ".js-paper-rank-work_7882200", }); 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$(".js-view-count[data-work-id=7882200]").text(description); $(".js-view-count-work_7882200").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_7882200").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="7882200"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3855" href="https://www.academia.edu/Documents/in/Polymorphism">Polymorphism</a>, <script data-card-contents-for-ri="3855" type="text/json">{"id":3855,"name":"Polymorphism","url":"https://www.academia.edu/Documents/in/Polymorphism?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3971" href="https://www.academia.edu/Documents/in/Protein_Folding">Protein Folding</a>, <script data-card-contents-for-ri="3971" type="text/json">{"id":3971,"name":"Protein Folding","url":"https://www.academia.edu/Documents/in/Protein_Folding?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7953" href="https://www.academia.edu/Documents/in/Molecular_Neuroscience">Molecular Neuroscience</a><script data-card-contents-for-ri="7953" type="text/json">{"id":7953,"name":"Molecular Neuroscience","url":"https://www.academia.edu/Documents/in/Molecular_Neuroscience?f_ri=86952","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=7882200]'), work: {"id":7882200,"title":"Amyloid Precursor Protein Gene ( APP ) Variation in Late-Onset Alzheimer’s Disease","created_at":"2014-08-05T06:01:36.248-07:00","url":"https://www.academia.edu/7882200/Amyloid_Precursor_Protein_Gene_APP_Variation_in_Late_Onset_Alzheimer_s_Disease?f_ri=86952","dom_id":"work_7882200","summary":"Mutations in the beta-amyloid precursor protein gene (APP) have been found in familial early-onset Alzheímer’s disease (AD). DNA variants at several genes have been linked to the risk of developing the most common late-onset form of AD (LOAD). A few studies analyzed the contribution of APP variants to LOAD, with negative or conflicting results. We determined the variation in the 18 APP exons and flanking intronic sequences in a total of 350 LOAD patients from Spain. A total of 13 nucleotide changes were found and 6 were new and not found among 340 healthy controls, including the only missense change (D243N). The in silico analysis suggested that none of them would have an effect on pre-mRNA splicing or protein folding (D243N). Patients and controls were also genotyped for three APP promoter polymorphisms, and none of them was significantly associated with LOAD. We concluded that APP variants would not contribute to the risk of developing LOAD in our population.","downloadable_attachments":[{"id":48303750,"asset_id":7882200,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":14731222,"first_name":"Mirna","last_name":"Diaz","domain_name":"independent","page_name":"MirnaDiaz","display_name":"Mirna Diaz","profile_url":"https://independent.academia.edu/MirnaDiaz?f_ri=86952","photo":"https://0.academia-photos.com/14731222/4012647/4685162/s65_mirna.diaz.jpg"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=86952","nofollow":false},{"id":3855,"name":"Polymorphism","url":"https://www.academia.edu/Documents/in/Polymorphism?f_ri=86952","nofollow":false},{"id":3971,"name":"Protein Folding","url":"https://www.academia.edu/Documents/in/Protein_Folding?f_ri=86952","nofollow":false},{"id":7953,"name":"Molecular Neuroscience","url":"https://www.academia.edu/Documents/in/Molecular_Neuroscience?f_ri=86952","nofollow":false},{"id":40516,"name":"Spain","url":"https://www.academia.edu/Documents/in/Spain?f_ri=86952"},{"id":50157,"name":"Molecular","url":"https://www.academia.edu/Documents/in/Molecular?f_ri=86952"},{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=86952"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=86952"},{"id":306990,"name":"Gene Polymorphism","url":"https://www.academia.edu/Documents/in/Gene_Polymorphism?f_ri=86952"},{"id":372410,"name":"Genotype","url":"https://www.academia.edu/Documents/in/Genotype?f_ri=86952"},{"id":735504,"name":"Genetic Association","url":"https://www.academia.edu/Documents/in/Genetic_Association?f_ri=86952"},{"id":865697,"name":"In Silico","url":"https://www.academia.edu/Documents/in/In_Silico?f_ri=86952"},{"id":1120234,"name":"Alzheimer Disease","url":"https://www.academia.edu/Documents/in/Alzheimer_Disease?f_ri=86952"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=86952"},{"id":1489115,"name":"Age of Onset","url":"https://www.academia.edu/Documents/in/Age_of_Onset?f_ri=86952"},{"id":1597877,"name":"Nucleotides","url":"https://www.academia.edu/Documents/in/Nucleotides?f_ri=86952"},{"id":2028686,"name":"Amyloid Beta Precursor Protein","url":"https://www.academia.edu/Documents/in/Amyloid_Beta_Precursor_Protein?f_ri=86952"},{"id":2482159,"name":"DNA mutational analysis","url":"https://www.academia.edu/Documents/in/DNA_mutational_analysis?f_ri=86952"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13186008 coauthored" data-work_id="13186008" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif 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data-has-card-for-ri="5069" href="https://www.academia.edu/Documents/in/Principal_Component_Analysis">Principal Component Analysis</a>, <script data-card-contents-for-ri="5069" type="text/json">{"id":5069,"name":"Principal Component Analysis","url":"https://www.academia.edu/Documents/in/Principal_Component_Analysis?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="28235" href="https://www.academia.edu/Documents/in/Multidisciplinary">Multidisciplinary</a>, <script data-card-contents-for-ri="28235" type="text/json">{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="86952" href="https://www.academia.edu/Documents/in/Haplotypes">Haplotypes</a>, <script data-card-contents-for-ri="86952" type="text/json">{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="168913" href="https://www.academia.edu/Documents/in/Human_Genome_Project">Human Genome Project</a><script data-card-contents-for-ri="168913" type="text/json">{"id":168913,"name":"Human Genome Project","url":"https://www.academia.edu/Documents/in/Human_Genome_Project?f_ri=86952","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13186008]'), work: {"id":13186008,"title":"HLA Diversity in the 1000 Genomes 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Analysis","url":"https://www.academia.edu/Documents/in/Principal_Component_Analysis?f_ri=86952","nofollow":false},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=86952","nofollow":false},{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=86952","nofollow":false},{"id":168913,"name":"Human Genome Project","url":"https://www.academia.edu/Documents/in/Human_Genome_Project?f_ri=86952","nofollow":false},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one?f_ri=86952"},{"id":309981,"name":"Human Genome","url":"https://www.academia.edu/Documents/in/Human_Genome?f_ri=86952"},{"id":372410,"name":"Genotype","url":"https://www.academia.edu/Documents/in/Genotype?f_ri=86952"},{"id":435727,"name":"Major histocompatibility complex","url":"https://www.academia.edu/Documents/in/Major_histocompatibility_complex?f_ri=86952"},{"id":489736,"name":"Linkage Disequilibrium","url":"https://www.academia.edu/Documents/in/Linkage_Disequilibrium?f_ri=86952"},{"id":577933,"name":"Genetic variation","url":"https://www.academia.edu/Documents/in/Genetic_variation?f_ri=86952"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_23480951" data-work_id="23480951" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/23480951/Influence_of_single_nucleotide_polymorphisms_in_factor_VIII_and_von_Willebrand_factor_genes_on_plasma_factor_VIII_activity_the_ARIC_Study">Influence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: the ARIC Study</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li 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class="InlineList-item-text" data-has-card-for-ri="80043" href="https://www.academia.edu/Documents/in/von_Willebrand_factor">von Willebrand factor</a><script data-card-contents-for-ri="80043" type="text/json">{"id":80043,"name":"von Willebrand factor","url":"https://www.academia.edu/Documents/in/von_Willebrand_factor?f_ri=86952","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=23480951]'), work: {"id":23480951,"title":"Influence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: the ARIC 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type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="42324" href="https://www.academia.edu/Documents/in/Heredity">Heredity</a>, <script data-card-contents-for-ri="42324" type="text/json">{"id":42324,"name":"Heredity","url":"https://www.academia.edu/Documents/in/Heredity?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="86952" href="https://www.academia.edu/Documents/in/Haplotypes">Haplotypes</a><script data-card-contents-for-ri="86952" type="text/json">{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=86952","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=75025188]'), work: {"id":75025188,"title":"Fine mapping of a QTL on chromosome 13 for submaximal exercise capacity 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Study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The stone marten is a widely distributed mustelid in the Palaearctic region that exhibits variable habitat preferences in different parts of its range. The species is a Holocene immigrant from southwest Asia which, according to fossil... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_58473017" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The stone marten is a widely distributed mustelid in the Palaearctic region that exhibits variable habitat preferences in different parts of its range. The species is a Holocene immigrant from southwest Asia which, according to fossil remains, followed the expansion of the Neolithic farming cultures into Europe and possibly colonized the Iberian Peninsula during the Early Neolithic (ca. 7,000 years BP). However, the population genetic structure and historical biogeography of this generalist carnivore remains essentially unknown. In this study we have combined mitochondrial DNA (mtDNA) sequencing (621 bp) and microsatellite genotyping (23 polymorphic markers) to infer the population genetic structure of the stone marten within the Iberian Peninsula. The mtDNA data revealed low haplotype and nucleotide diversities and a lack of phylogeographic structure, most likely due to a recent colonization of the Iberian Peninsula by a few mtDNA lineages during the Early Neolithic. The microsatel...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/58473017" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="947dc7ac67b0831df1f0349c9ba9ee0f" rel="nofollow" data-download="{"attachment_id":72867148,"asset_id":58473017,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/72867148/download_file?st=MTczMjc4NTIwNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="7335670" href="https://independent.academia.edu/AritzRuizGonzalez">Aritz Ruiz-Gonzalez</a><script data-card-contents-for-user="7335670" type="text/json">{"id":7335670,"first_name":"Aritz","last_name":"Ruiz-Gonzalez","domain_name":"independent","page_name":"AritzRuizGonzalez","display_name":"Aritz Ruiz-Gonzalez","profile_url":"https://independent.academia.edu/AritzRuizGonzalez?f_ri=86952","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_58473017 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="58473017"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 58473017, container: ".js-paper-rank-work_58473017", }); 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quotient (IQ) has significant genetic components. We performed a low-density genome-wide association analysis with a family-based association test to identify... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24880161" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Family, twin, and adoption studies have indicated that human intelligence quotient (IQ) has significant genetic components. We performed a low-density genome-wide association analysis with a family-based association test to identify genetic variants influencing IQ, as measured by Wechsler Adult Intelligence Scale full-score IQ (FSIQ). We examined 11,120 single-nucleotide polymorphisms (SNPs) from the Affymetrix GeneChips 10K mapping array genotyped in 292 nuclear families from Genetic Analysis Workshop 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). A replication analysis was performed using part of International Multi-Center ADHD Genetics Project (IMAGE) dataset. Twenty-two SNPs were identified as having suggestive associations with IQ (p&lt;10(-3)) in the COGA sample and eleven of the SNPs were located within known genes. In particular, NTM at 11q25 (rs411280, p = 0.000764) and NR3C2 at 4q31.1 (rs3846329, p = 0.000675) were two novel genes which hav...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24880161" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a66281a861bf298251874791388f74bb" rel="nofollow" data-download="{"attachment_id":45201060,"asset_id":24880161,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45201060/download_file?st=MTczMjc4NTIwNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39752704" href="https://independent.academia.edu/YuePan12">Yue Pan</a><script data-card-contents-for-user="39752704" type="text/json">{"id":39752704,"first_name":"Yue","last_name":"Pan","domain_name":"independent","page_name":"YuePan12","display_name":"Yue Pan","profile_url":"https://independent.academia.edu/YuePan12?f_ri=86952","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24880161 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24880161"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24880161, container: ".js-paper-rank-work_24880161", }); 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We performed a low-density genome-wide association analysis with a family-based association test to identify genetic variants influencing IQ, as measured by Wechsler Adult Intelligence Scale full-score IQ (FSIQ). We examined 11,120 single-nucleotide polymorphisms (SNPs) from the Affymetrix GeneChips 10K mapping array genotyped in 292 nuclear families from Genetic Analysis Workshop 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). A replication analysis was performed using part of International Multi-Center ADHD Genetics Project (IMAGE) dataset. Twenty-two SNPs were identified as having suggestive associations with IQ (p\u0026lt;10(-3)) in the COGA sample and eleven of the SNPs were located within known genes. In particular, NTM at 11q25 (rs411280, p = 0.000764) and NR3C2 at 4q31.1 (rs3846329, p = 0.000675) were two novel genes which hav...","downloadable_attachments":[{"id":45201060,"asset_id":24880161,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39752704,"first_name":"Yue","last_name":"Pan","domain_name":"independent","page_name":"YuePan12","display_name":"Yue Pan","profile_url":"https://independent.academia.edu/YuePan12?f_ri=86952","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=86952","nofollow":false},{"id":2674,"name":"Intelligence","url":"https://www.academia.edu/Documents/in/Intelligence?f_ri=86952","nofollow":false},{"id":3855,"name":"Polymorphism","url":"https://www.academia.edu/Documents/in/Polymorphism?f_ri=86952","nofollow":false},{"id":12054,"name":"International 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Bertranpetit","profile_url":"https://independent.academia.edu/JaumeBertranpetit?f_ri=86952","photo":"https://0.academia-photos.com/30923651/96115563/85140608/s65_jaume.bertranpetit.jpeg"}],"research_interests":[{"id":4480,"name":"Population Genetics","url":"https://www.academia.edu/Documents/in/Population_Genetics?f_ri=86952","nofollow":false},{"id":6946,"name":"Cystic Fibrosis","url":"https://www.academia.edu/Documents/in/Cystic_Fibrosis?f_ri=86952","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=86952","nofollow":false},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=86952","nofollow":false},{"id":75826,"name":"Europe","url":"https://www.academia.edu/Documents/in/Europe?f_ri=86952"},{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=86952"},{"id":191815,"name":"Biological 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with the Common 55R-94A-247H Variant Haplotype of GZMB (Encoding Granzyme B)</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/50306727" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="daed395a443f869cb2671e4859e73318" rel="nofollow" data-download="{"attachment_id":68342330,"asset_id":50306727,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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B)","created_at":"2021-07-27T11:08:02.257-07:00","url":"https://www.academia.edu/50306727/Risk_of_Generalized_Vitiligo_Is_Associated_with_the_Common_55R_94A_247H_Variant_Haplotype_of_GZMB_Encoding_Granzyme_B_?f_ri=86952","dom_id":"work_50306727","summary":null,"downloadable_attachments":[{"id":68342330,"asset_id":50306727,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32399450,"first_name":"Richard","last_name":"Spritz","domain_name":"independent","page_name":"RichardSpritz","display_name":"Richard Spritz","profile_url":"https://independent.academia.edu/RichardSpritz?f_ri=86952","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=86952","nofollow":false},{"id":192721,"name":"Risk 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Genetics","url":"https://www.academia.edu/Documents/in/Population_Genetics?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4967" href="https://www.academia.edu/Documents/in/Molecular_Evolution">Molecular Evolution</a>, <script data-card-contents-for-ri="4967" type="text/json">{"id":4967,"name":"Molecular Evolution","url":"https://www.academia.edu/Documents/in/Molecular_Evolution?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="86952" href="https://www.academia.edu/Documents/in/Haplotypes">Haplotypes</a><script data-card-contents-for-ri="86952" type="text/json">{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=86952","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16665484]'), work: {"id":16665484,"title":"The evolution and population genetics of the ALDH2 locus: 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the first-line treatment of malaria in Haiti. Given the challenges of conducting in vivo drug efficacy trials in low-endemic settings like Haiti, molecular surveillance for drug resistance markers is a reasonable... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_61591240" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Chloroquine (CQ) remains the first-line treatment of malaria in Haiti. Given the challenges of conducting in vivo drug efficacy trials in low-endemic settings like Haiti, molecular surveillance for drug resistance markers is a reasonable approach for detecting resistant parasites. In this study, 349 blood spots were collected from suspected malaria cases in areas in and around Port-au-Prince from March to July 2010. Among them, 121 samples that were Plasmodium falciparum positive by polymerase chain reaction were genotyped for drug-resistant pfcrt, pfdhfr, pfdhps, and pfmdr1 alleles. Among the 108 samples that were successfully sequenced for CQ resistant markers in pfcrt, 107 were wild type (CVMNK), whereas one sample carried a CQ-resistant allele (CVIET). Neutral microsatellite genotyping revealed that the CQ-resistant isolate was distinct from all other samples in this study. Furthermore, the remaining parasite specimens appeared to be genetically distinct from other reported Cent...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61591240" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="044626378488478d2a54ee4c86b8795f" rel="nofollow" data-download="{"attachment_id":74577590,"asset_id":61591240,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74577590/download_file?st=MTczMjc4NTIwNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="51418770" href="https://independent.academia.edu/JBoncy">Jacques Boncy</a><script data-card-contents-for-user="51418770" type="text/json">{"id":51418770,"first_name":"Jacques","last_name":"Boncy","domain_name":"independent","page_name":"JBoncy","display_name":"Jacques Boncy","profile_url":"https://independent.academia.edu/JBoncy?f_ri=86952","photo":"https://0.academia-photos.com/51418770/88100736/76791372/s65_jacques.boncy.png"}</script></span></span></li><li class="js-paper-rank-work_61591240 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61591240"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61591240, container: ".js-paper-rank-work_61591240", }); 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class="InlineList-item-text" data-has-card-for-ri="156" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4967" href="https://www.academia.edu/Documents/in/Molecular_Evolution">Molecular Evolution</a>, <script data-card-contents-for-ri="4967" type="text/json">{"id":4967,"name":"Molecular Evolution","url":"https://www.academia.edu/Documents/in/Molecular_Evolution?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="49123" href="https://www.academia.edu/Documents/in/Saccharomyces_cerevisiae">Saccharomyces cerevisiae</a><script data-card-contents-for-ri="49123" type="text/json">{"id":49123,"name":"Saccharomyces 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href="https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine">Complementary and Alternative Medicine</a>, <script data-card-contents-for-ri="4083" type="text/json">{"id":4083,"name":"Complementary and Alternative Medicine","url":"https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a><script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=86952","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20702676]'), work: {"id":20702676,"title":"CFTR gene mutations - including three novel nucleotide substitutions - and haplotype background in patients with asthma, disseminated bronchiectasis and chronic obstructive 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in families with hereditary diffuse gastric cancer</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Hereditary diffuse gastric cancer is caused by germline mutations in the epithelial cadherin (CDH1) gene and is characterized by an increased risk for diffuse gastric cancer and lobular breast cancer.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/19074243" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4c3cfba9282111ddcc7e4652f8e95943" rel="nofollow" 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href="https://independent.academia.edu/PizzutiAntonio">Antonio Pizzuti</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/MariaRedal">Maria Redal</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/HLynch1">H. Lynch</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-19074243'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-19074243').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_19074243 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="19074243"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 19074243, container: ".js-paper-rank-work_19074243", }); });</script></li><li class="js-percentile-work_19074243 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19074243; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_19074243"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_19074243 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="19074243"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19074243; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19074243]").text(description); $(".js-view-count-work_19074243").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_19074243").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="19074243"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="46840" href="https://www.academia.edu/Documents/in/Newfoundland_and_Labrador">Newfoundland and Labrador</a>, <script data-card-contents-for-ri="46840" type="text/json">{"id":46840,"name":"Newfoundland and Labrador","url":"https://www.academia.edu/Documents/in/Newfoundland_and_Labrador?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47904" href="https://www.academia.edu/Documents/in/Genetic_counseling">Genetic counseling</a>, <script data-card-contents-for-ri="47904" type="text/json">{"id":47904,"name":"Genetic counseling","url":"https://www.academia.edu/Documents/in/Genetic_counseling?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="74780" href="https://www.academia.edu/Documents/in/Mutation">Mutation</a>, <script data-card-contents-for-ri="74780" type="text/json">{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="86952" href="https://www.academia.edu/Documents/in/Haplotypes">Haplotypes</a><script data-card-contents-for-ri="86952" type="text/json">{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=86952","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=19074243]'), work: {"id":19074243,"title":"Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer","created_at":"2015-11-26T21:30:18.080-08:00","url":"https://www.academia.edu/19074243/Founder_and_recurrent_CDH1_mutations_in_families_with_hereditary_diffuse_gastric_cancer?f_ri=86952","dom_id":"work_19074243","summary":"Hereditary diffuse gastric cancer is caused by germline mutations in the epithelial cadherin (CDH1) gene and is characterized by an increased risk for diffuse gastric cancer and lobular breast cancer.","downloadable_attachments":[{"id":40416196,"asset_id":19074243,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39232710,"first_name":"Gianpaolo","last_name":"Suriano","domain_name":"ipatimup","page_name":"GianpaoloSuriano","display_name":"Gianpaolo Suriano","profile_url":"https://ipatimup.academia.edu/GianpaoloSuriano?f_ri=86952","photo":"/images/s65_no_pic.png"},{"id":39412404,"first_name":"Jennifer","last_name":"Stroop","domain_name":"independent","page_name":"JenniferStroop","display_name":"Jennifer Stroop","profile_url":"https://independent.academia.edu/JenniferStroop?f_ri=86952","photo":"/images/s65_no_pic.png"},{"id":43121048,"first_name":"Marc","last_name":"Greenblatt","domain_name":"independent","page_name":"MarcGreenblatt","display_name":"Marc Greenblatt","profile_url":"https://independent.academia.edu/MarcGreenblatt?f_ri=86952","photo":"/images/s65_no_pic.png"},{"id":41210294,"first_name":"Antonio","last_name":"Pizzuti","domain_name":"independent","page_name":"PizzutiAntonio","display_name":"Antonio Pizzuti","profile_url":"https://independent.academia.edu/PizzutiAntonio?f_ri=86952","photo":"/images/s65_no_pic.png"},{"id":39416240,"first_name":"Maria","last_name":"Redal","domain_name":"independent","page_name":"MariaRedal","display_name":"Maria Redal","profile_url":"https://independent.academia.edu/MariaRedal?f_ri=86952","photo":"/images/s65_no_pic.png"},{"id":39556863,"first_name":"H.","last_name":"Lynch","domain_name":"independent","page_name":"HLynch1","display_name":"H. 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Onset","url":"https://www.academia.edu/Documents/in/Age_of_Onset?f_ri=86952"},{"id":1504413,"name":"JAMA","url":"https://www.academia.edu/Documents/in/JAMA?f_ri=86952"},{"id":1738247,"name":"Founder Effect","url":"https://www.academia.edu/Documents/in/Founder_Effect?f_ri=86952"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17674451 coauthored" data-work_id="17674451" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17674451/Response_to_hydroxyurea_in_%CE%B2_thalassemia_major_and_intermedia_Experience_in_western_India">Response to hydroxyurea in β thalassemia major and intermedia: Experience in western India</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17674451" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e5583b7180464a530c5e54562b58ef33" rel="nofollow" data-download="{"attachment_id":39651413,"asset_id":17674451,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39651413/download_file?st=MTczMjc4NTIwNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" 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js-additional-users-17674451"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/FarahJijina">Farah Jijina</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-17674451'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-17674451').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_17674451 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17674451"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17674451, container: ".js-paper-rank-work_17674451", }); });</script></li><li class="js-percentile-work_17674451 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span 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$(".js-view-count[data-work-id=17674451]").text(description); $(".js-view-count-work_17674451").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_17674451").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="17674451"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="619" href="https://www.academia.edu/Documents/in/Hematology">Hematology</a>, <script data-card-contents-for-ri="619" type="text/json">{"id":619,"name":"Hematology","url":"https://www.academia.edu/Documents/in/Hematology?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="3855" href="https://www.academia.edu/Documents/in/Polymorphism">Polymorphism</a>, <script data-card-contents-for-ri="3855" type="text/json">{"id":3855,"name":"Polymorphism","url":"https://www.academia.edu/Documents/in/Polymorphism?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=86952","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a><script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=86952","nofollow":false}</script></span></li><script>(function(){ if (true) { new 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Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=86952","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=86952","nofollow":false},{"id":43838,"name":"India","url":"https://www.academia.edu/Documents/in/India?f_ri=86952"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=86952"},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=86952"},{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=86952"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=86952"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=86952"},{"id":310960,"name":"mRna expression levels","url":"https://www.academia.edu/Documents/in/mRna_expression_levels?f_ri=86952"},{"id":731153,"name":"Hydroxyurea","url":"https://www.academia.edu/Documents/in/Hydroxyurea?f_ri=86952"},{"id":979424,"name":"Beta Thalassemia","url":"https://www.academia.edu/Documents/in/Beta_Thalassemia?f_ri=86952"},{"id":1490333,"name":"Fetal Hemoglobin","url":"https://www.academia.edu/Documents/in/Fetal_Hemoglobin?f_ri=86952"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation?f_ri=86952"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_76478259" data-work_id="76478259" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/76478259/Genetic_Diversity_and_Population_Genetic_Structure_Analysis_of_Echinococcus_granulosus_sensu_stricto_Complex_Based_on_Mitochondrial_DNA_Signature">Genetic Diversity and Population Genetic Structure Analysis of Echinococcus granulosus sensu stricto Complex Based on Mitochondrial DNA Signature</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The genetic diversity and population genetics of the Echinococcus granulosus sensu stricto complex were investigated based on sequencing of mitochondrial DNA (mtDNA). Total 81 isolates of hydatid cyst collected from ungulate animals from... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_76478259" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The genetic diversity and population genetics of the Echinococcus granulosus sensu stricto complex were investigated based on sequencing of mitochondrial DNA (mtDNA). Total 81 isolates of hydatid cyst collected from ungulate animals from different geographical areas of North India were identified by sequencing of cytochrome c oxidase subunit1 (coxi) gene. Three genotypes belonging to E. granulosus sensu stricto complex were identified (G1, G2 and G3 genotypes). Further the nucleotide sequences (retrieved from GenBank) for the coxi gene from seven populations of E. granulosus sensu stricto complex covering 6 continents, were compared with sequences of isolates analysed in this study. Molecular diversity indices represent overall high mitochondrial DNA diversity for these populations, but low nucleotide diversity between haplotypes. The neutrality tests were used to analyze signatures of historical demographic events. The Tajima’s D test and Fu’s FS test showed negative value, indicat...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/76478259" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9437e999fca13e1b5f8b3e8d9621e078" rel="nofollow" data-download="{"attachment_id":84174310,"asset_id":76478259,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/84174310/download_file?st=MTczMjc4NTIwNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="16129327" href="https://pgimer.academia.edu/RakeshSehgal">Rakesh Sehgal</a><script data-card-contents-for-user="16129327" type="text/json">{"id":16129327,"first_name":"Rakesh","last_name":"Sehgal","domain_name":"pgimer","page_name":"RakeshSehgal","display_name":"Rakesh Sehgal","profile_url":"https://pgimer.academia.edu/RakeshSehgal?f_ri=86952","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_76478259 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="76478259"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 76478259, container: ".js-paper-rank-work_76478259", }); 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Total 81 isolates of hydatid cyst collected from ungulate animals from different geographical areas of North India were identified by sequencing of cytochrome c oxidase subunit1 (coxi) gene. Three genotypes belonging to E. granulosus sensu stricto complex were identified (G1, G2 and G3 genotypes). Further the nucleotide sequences (retrieved from GenBank) for the coxi gene from seven populations of E. granulosus sensu stricto complex covering 6 continents, were compared with sequences of isolates analysed in this study. Molecular diversity indices represent overall high mitochondrial DNA diversity for these populations, but low nucleotide diversity between haplotypes. The neutrality tests were used to analyze signatures of historical demographic events. The Tajima’s D test and Fu’s FS test showed negative value, indicat...","downloadable_attachments":[{"id":84174310,"asset_id":76478259,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":16129327,"first_name":"Rakesh","last_name":"Sehgal","domain_name":"pgimer","page_name":"RakeshSehgal","display_name":"Rakesh Sehgal","profile_url":"https://pgimer.academia.edu/RakeshSehgal?f_ri=86952","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering?f_ri=86952","nofollow":false},{"id":146,"name":"Bioinformatics","url":"https://www.academia.edu/Documents/in/Bioinformatics?f_ri=86952","nofollow":false},{"id":498,"name":"Physics","url":"https://www.academia.edu/Documents/in/Physics?f_ri=86952","nofollow":false},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=86952","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=86952"},{"id":8014,"name":"Life Sciences","url":"https://www.academia.edu/Documents/in/Life_Sciences?f_ri=86952"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=86952"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=86952"},{"id":43838,"name":"India","url":"https://www.academia.edu/Documents/in/India?f_ri=86952"},{"id":63093,"name":"Mitochondrial DNA","url":"https://www.academia.edu/Documents/in/Mitochondrial_DNA?f_ri=86952"},{"id":66744,"name":"Biomedical Research","url":"https://www.academia.edu/Documents/in/Biomedical_Research?f_ri=86952"},{"id":84913,"name":"Sheep","url":"https://www.academia.edu/Documents/in/Sheep?f_ri=86952"},{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=86952"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one?f_ri=86952"},{"id":252969,"name":"Goats","url":"https://www.academia.edu/Documents/in/Goats?f_ri=86952"},{"id":260829,"name":"Cattle","url":"https://www.academia.edu/Documents/in/Cattle?f_ri=86952"},{"id":577933,"name":"Genetic variation","url":"https://www.academia.edu/Documents/in/Genetic_variation?f_ri=86952"},{"id":1793091,"name":"Buffaloes","url":"https://www.academia.edu/Documents/in/Buffaloes?f_ri=86952"},{"id":1943368,"name":"Echinococcus granulosus","url":"https://www.academia.edu/Documents/in/Echinococcus_granulosus?f_ri=86952"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_68007629" data-work_id="68007629" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/68007629/Melanesian_and_Asian_origins_of_Polynesians_mtDNA_and_Y_chromosome_gradients_across_the_Pacific">Melanesian and Asian origins of Polynesians: mtDNA and Y chromosome gradients across the Pacific</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The human settlement of the Pacific Islands represents one of the most recent major migration events of mankind. Polynesians originated in Asia according to linguistic evidence or in Melanesia according to archaeological evidence. To shed... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_68007629" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The human settlement of the Pacific Islands represents one of the most recent major migration events of mankind. Polynesians originated in Asia according to linguistic evidence or in Melanesia according to archaeological evidence. To shed light on the genetic origins of Polynesians, we investigated over 400 Polynesians from 8 island groups, in comparison with over 900 individuals from potential parental populations of Melanesia, Southeast and East Asia, and Australia, by means of Y chromosome (NRY) and mitochondrial DNA ( ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/68007629" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="42e4df6ac5738c16ec8161a550f1d559" rel="nofollow" data-download="{"attachment_id":78641059,"asset_id":68007629,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/78641059/download_file?st=MTczMjc4NTIwNiw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="88242809" href="https://independent.academia.edu/ClaireMoyse">Claire Moyse</a><script data-card-contents-for-user="88242809" type="text/json">{"id":88242809,"first_name":"Claire","last_name":"Moyse","domain_name":"independent","page_name":"ClaireMoyse","display_name":"Claire Moyse","profile_url":"https://independent.academia.edu/ClaireMoyse?f_ri=86952","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_68007629 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="68007629"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 68007629, container: ".js-paper-rank-work_68007629", }); 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To shed light on the genetic origins of Polynesians, we investigated over 400 Polynesians from 8 island groups, in comparison with over 900 individuals from potential parental populations of Melanesia, Southeast and East Asia, and Australia, by means of Y chromosome (NRY) and mitochondrial DNA ( ...","downloadable_attachments":[{"id":78641059,"asset_id":68007629,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":88242809,"first_name":"Claire","last_name":"Moyse","domain_name":"independent","page_name":"ClaireMoyse","display_name":"Claire Moyse","profile_url":"https://independent.academia.edu/ClaireMoyse?f_ri=86952","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":155,"name":"Evolutionary Biology","url":"https://www.academia.edu/Documents/in/Evolutionary_Biology?f_ri=86952","nofollow":false},{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=86952","nofollow":false},{"id":2513,"name":"Molecular 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