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Sample Preparation | SPT Labtech

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image" style="background-image: url('https://www.sptlabtech.com/hubfs/Email/2021%20Content%20Compendiums/Structural%20Biology/sb-chameleon.jpg')"> <div class="overlay"> <div class="grey-overlay"> <div class="container"> <div class="breadcrumb-container"> <ol class="breadcrumb custom-breadcrumb"> <li class="breadcrumb-item" data="1"><a href="/">Home</a></li> <li class="breadcrumb-item"> Sample Preparation </li> </ol> </div> </div> <div class="container"> <div class="flex"> <div class="application-bnr-text medium"> <div class="text-block"> <h1 class="title-symbol">Cryo-EM<br>Sample Preparation</h1> <div id="hs_cos_wrapper_widget_1629795691696_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_rich_text" data-hs-cos-field="banner_content.description"><p>Optimized sample and grid preparation is vital to achieving the best possible outcomes in structural biology, by delivering consistently high-quality images and data.&nbsp;</p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-3 main_area-row-1-padding main_area-row-1-max-width-section-centering dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-4 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1631270137283" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1631270137283_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h2 style="color: black;"><span>Good</span><span> Sample Preparation</span><span> </span><span>for </span><span>Cryo-EM</span><span>: What, Why and How</span><span>?</span></h2> <p><span data-contrast="auto"><a href="/applications/structural-biology/cryo-em" rel="noopener">Cryo-electron microscopy (cryo-EM)</a> is an invaluable tool in the structural biologist’s toolkit, providing high-resolution information for samples that were previously resistant to other methods such as x-ray crystallography. Researchers are now able to investigate at a single atom level a wider range of proteins, including many important drug targets, to gain a deeper understating of their function within disease related pathways.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}">&nbsp;</span></p> <p><span data-contrast="auto">However, time on high-performance cryo-EM microscopes to collect the necessary data is expensive, and often the availability is restricted. To ensure that you’re getting the most out of your investment, care is needed to optimize your sample concentration, quality and homogeneity, as well choosing the right grid and optimizing your grid preparation protocol.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}">&nbsp;</span></p></span></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-5 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1677587226418" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <hr></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-6 cell_1631270137456-row-2-vertical-alignment dnd-row"> <div class="row-fluid "> <div class="span6 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="6"> <div class="row-fluid-wrapper row-depth-1 row-number-7 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1688030935328" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="button"> <button> <a href="#streamline"> Streamlines cryo-EM Sample Preparation </a> </button> </div></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> <div class="span6 widget-span widget-type-cell cell_1677586953929-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="6" data-w="6"> <div class="row-fluid-wrapper row-depth-1 row-number-8 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1688030948403" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="button"> <button> <a href="#high"> High-Performance Sample Support </a> </button> </div></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-9 main_area-row-2-max-width-section-centering main_area-row-2-background-color main_area-row-2-padding dnd-section main_area-row-2-background-layers"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-10 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1631096298084" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1631096298084_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><div class="anchor-point" id="medicinal-chemistry"> <div class="hs-embed-wrapper"><div class="hs-embed-content-wrapper"><h2 id="streamline" data-mce-fragment="1">Streamline cryo-EM Sample Preparation</h2></div></div> <p><span data-contrast="auto">Optimal <a href="/resources/a-closer-look-at-chameleon-providing-rapid-and-efficient-path-to-quality-frozen-grids-for-cryo-em" rel="noopener">cryo-EM grid preparation</a> should maintain sample integrity, minimize damage, reduce contamination, and ensure consistency across experiments. However, it is typically a manual and labor-intensive process, and achieving the optimal grid for data collection can be a challenging task.&nbsp;</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}">&nbsp;</span></p> </div></span></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-11 main_area-row-3-max-width-section-centering main_area-row-3-vertical-alignment main_area-row-3-background-layers dnd-section main_area-row-3-background-color main_area-row-3-padding"> <div class="row-fluid "> <div class="span4 widget-span widget-type-cell cell_1677584480579-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="0" data-w="4"> <div class="row-fluid-wrapper row-depth-1 row-number-12 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget widget_1677584456290-flexbox-positioning dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1677584456290" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_widget_1677584456290_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="linked_image"><a href="https://www.sptlabtech.com/products/chameleon" target="_parent" id="hs-link-widget_1677584456290_" style="border-width:0px;border:0px;"><img src="https://www.sptlabtech.com/hubfs/SPT%20Labtech%20Website/06%20-%20Products/05%20-%20chameleon/01%20-%20chameleon/chameleon_center_banner.png" class="hs-image-widget " style="max-width: 100%; height: auto;" alt="chameleon_center_banner" title="chameleon_center_banner" loading="lazy"></a></span></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> <div class="span8 widget-span widget-type-cell cell_16775844805802-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="4" data-w="8"> <div class="row-fluid-wrapper row-depth-1 row-number-13 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1677584509865" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-header" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_widget_1677584509865_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_header" style="" data-hs-cos-general-type="widget" data-hs-cos-type="header"><h3>chameleon, automate consistency</h3></span></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-14 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1677584480565" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="hs-accordion"> <div class="hs-accordion__item" aria-expanded=""> <button> <h6>More about chameleon</h6> <span class="hs-accordion__item-icon"></span> </button> <main> <div class="hs-accordion__item-content bullet-list-points"> <p><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><a href="/products/chameleon" rel="noopener"><span>c</span></a><span><a href="/products/chameleon" rel="noopener" id="__hsNewLink">hameleon</a> offers unparalleled capabilities in </span><span>cryo-EM </span><span>grid</span><span> </span><span>preparation, combining next-generation automation, blot-free </span><span>technology,</span><span> and high-speed plunging.</span><span> </span><span>With </span><span>intuitive, </span><span>guided workflows to simplify setup and operation, </span><span>chameleon </span><span>remov</span><span>es</span><span> the major bottleneck in</span><span> th</span><span>is workflow.</span></span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}">&nbsp;</span></p> </div> </main> </div> <div class="hs-accordion__item" aria-expanded=""> <button> <h6>How does this help my sample preparation?</h6> <span class="hs-accordion__item-icon"></span> </button> <main> <div class="hs-accordion__item-content bullet-list-points"> <p><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>chamel</span><span>e</span><span>on</span><span> enables users of all experience </span><span>levels </span><span>to </span><span>produce high-quality grids reliably and consistently</span><span> for a wide range of biological samples</span><span>,</span><span> with </span><span>optimal</span><span> ice thickness and even</span><span>ly</span><span> distributed particles</span><span>.</span><span> </span><span>Its p</span><span>recise, automated grid handling prevents any manual </span><span>sample </span><span>loss or damage. </span><span>The ability to screen grid</span><span> quality prior to imaging</span><span> </span><span>leads</span><span> to</span><span> more efficient use of available microscope time which translates through to reducing costs.</span></span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}">&nbsp;</span></p> </div> </main> </div> </div></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-15 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget widget_1677584864867-flexbox-positioning dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1677584864867" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <a class="hs-button " href="https://www.sptlabtech.com/products/chameleon" id="hs-button_widget_1677584864867" rel=""> Explore chameleon </a> </div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-16 main_area-row-4-max-width-section-centering dnd-section main_area-row-4-padding"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-17 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_16775878895682" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_16775878895682_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><div class="anchor-point" id="medicinal-chemistry"> <div class="hs-embed-wrapper"><div class="hs-embed-content-wrapper"><h2 id="high" data-mce-fragment="1">High-Performance Sample Support</h2></div></div> <p><span>Support grids play a critical role in the cryo-EM sample preparation process.</span><span> </span><span>The nature of your biological sample </span><span>determines</span><span> the </span><span>optimal</span><span> </span><span>grid geometry and material, so </span><span>it is</span><span> important to choose the right grid that will yield the best results for you,</span> enter <a href="https://www.quantifoil.com/" rel="noopener">Quantifoil</a>.</p> </div></span></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-18 main_area-row-5-vertical-alignment dnd-section main_area-row-5-padding main_area-row-5-background-layers main_area-row-5-background-color main_area-row-5-max-width-section-centering"> <div class="row-fluid "> <div class="span8 widget-span widget-type-cell dnd-column cell_1677585613908-vertical-alignment" style="" data-widget-type="cell" data-x="0" data-w="8"> <div class="row-fluid-wrapper row-depth-1 row-number-19 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_16775856038398" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-header" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_module_16775856038398_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_header" style="" data-hs-cos-general-type="widget" data-hs-cos-type="header"><h3>Quantifoil, market-leading cryo-electron microscopy support grids</h3></span></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-20 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_16775856038399" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="hs-accordion"> <div class="hs-accordion__item" aria-expanded=""> <button> <h6>More about Quantifoil</h6> <span class="hs-accordion__item-icon"></span> </button> <main> <div class="hs-accordion__item-content bullet-list-points"> <p><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>Quantifoil</span><span> is </span><span>the</span><span> leading provider of cryo-electron microscopy support grids</span><span>. </span><span>The growing portfolio</span><span> </span><span>feature</span><span>s</span><span> </span><span>cryo-EM </span><span>support films with an array of </span><span>convenient predefined hole size</span><span>s</span><span>, </span><span>shapes,</span><span> and arrangement</span><span>s</span><span> on a full range of </span><span>grids</span><span>, to deliver high-performance</span><span> </span><span>for all structural biology applications, as well as for the wider electron microscopy community.</span></span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}">&nbsp;</span></p> </div> </main> </div> <div class="hs-accordion__item" aria-expanded=""> <button> <h6>How does this help my sample preparation?</h6> <span class="hs-accordion__item-icon"></span> </button> <main> <div class="hs-accordion__item-content bullet-list-points"> <p><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span data-ccp-parastyle="Normal (Web)">Correct </span><span data-ccp-parastyle="Normal (Web)">preparation</span><span data-ccp-parastyle="Normal (Web)"> is essential for </span><span data-ccp-parastyle="Normal (Web)">obtaining high quality</span><span data-ccp-parastyle="Normal (Web)"> </span><span data-ccp-parastyle="Normal (Web)">cry</span><span data-ccp-parastyle="Normal (Web)">o</span><span data-ccp-parastyle="Normal (Web)">-EM</span><span data-ccp-parastyle="Normal (Web)"> structures every time. </span><span data-ccp-parastyle="Normal (Web)">By s</span><span data-ccp-parastyle="Normal (Web)">electing the right </span><span data-ccp-parastyle="Normal (Web)">support grid and </span><span data-ccp-parastyle="Normal (Web)">optimizing</span><span data-ccp-parastyle="Normal (Web)"> your grid preparation</span><span data-ccp-parastyle="Normal (Web)">, you prevent wasted time at the microscope and </span><span data-ccp-parastyle="Normal (Web)">maintain</span><span data-ccp-parastyle="Normal (Web)"> sample </span><span data-ccp-parastyle="Normal (Web)">integrity, </span><span data-ccp-parastyle="Normal (Web)">increas</span><span data-ccp-parastyle="Normal (Web)">ing</span><span data-ccp-parastyle="Normal (Web)"> your chance of success while also </span><span data-ccp-parastyle="Normal (Web)">improving productivit</span><span data-ccp-parastyle="Normal (Web)">y.&nbsp;</span></span><span data-ccp-props="{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}">&nbsp;</span></p> </div> </main> </div> </div></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-21 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget module_167758560383910-flexbox-positioning dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_167758560383910" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <a class="hs-button " href="https://www.quantifoil.com/" id="hs-button_module_167758560383910" rel=""> Explore Quantifoil </a> </div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> <div class="span4 widget-span widget-type-cell cell_1677585603839-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="8" data-w="4"> <div class="row-fluid-wrapper row-depth-1 row-number-22 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget module_16775856038394-flexbox-positioning dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_16775856038394" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_module_16775856038394_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="linked_image"><a href="https://www.quantifoil.com/" target="_parent" id="hs-link-module_16775856038394_" style="border-width:0px;border:0px;"><img src="https://www.sptlabtech.com/hubfs/Quantifoil%20Website/4.0%20-%20QF%20-%20Products/4.1%20-%20QF%20-%20QUANTIFOIL/QUANTIFOIL-circular.jpg" class="hs-image-widget " style="max-width: 100%; height: auto;" alt="QUANTIFOIL-circular" title="QUANTIFOIL-circular" loading="lazy"></a></span></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-23 main_area-row-6-background-layers main_area-row-6-padding dnd-section main_area-row-6-background-color main_area-row-6-max-width-section-centering"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-24 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1677838778357" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1677838778357_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span data-ccp-parastyle="Normal (Web)">Correct </span><span data-ccp-parastyle="Normal (Web)">preparation</span><span data-ccp-parastyle="Normal (Web)"> is essential for </span><span data-ccp-parastyle="Normal (Web)">obtaining high quality</span><span data-ccp-parastyle="Normal (Web)"> </span><span data-ccp-parastyle="Normal (Web)">cry</span><span data-ccp-parastyle="Normal (Web)">o</span><span data-ccp-parastyle="Normal (Web)">-EM</span><span data-ccp-parastyle="Normal (Web)"> structures every time. </span><span data-ccp-parastyle="Normal (Web)">By s</span><span data-ccp-parastyle="Normal (Web)">electing the right </span><span data-ccp-parastyle="Normal (Web)">support grid and </span><span data-ccp-parastyle="Normal (Web)">optimizing</span><span data-ccp-parastyle="Normal (Web)"> your grid preparation</span><span data-ccp-parastyle="Normal (Web)">, you prevent wasted time at the microscope and </span><span data-ccp-parastyle="Normal (Web)">maintain</span><span data-ccp-parastyle="Normal (Web)"> sample </span><span data-ccp-parastyle="Normal (Web)">integrity, </span><span data-ccp-parastyle="Normal (Web)">increas</span><span data-ccp-parastyle="Normal (Web)">ing</span><span data-ccp-parastyle="Normal (Web)"> your chance of success while also </span><span data-ccp-parastyle="Normal (Web)">improving productivit</span><span data-ccp-parastyle="Normal (Web)">y.&nbsp;</span></span><span data-ccp-props="{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335559740&quot;:240}">&nbsp;</span></p> <h6 style="text-align: center;"><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>Contact us today to learn more about our </span><span>cryo-EM </span><span>sample preparation solutions and how they can </span><span>benefit</span><span> your laboratory operations.</span></span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335551550&quot;:2,&quot;335551620&quot;:2,&quot;335559739&quot;:160,&quot;335559740&quot;:259}">&nbsp;</span></h6></span></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-25 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget module_1677839592453-flexbox-positioning dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div 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class="row-fluid-wrapper row-depth-1 row-number-27 dnd-section main_area-row-7-padding main_area-row-7-force-full-width-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_main_area-module-11" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="home-section5" id="Latest-Resources"> <div class="container"> <h2>Latest Resources About Sample Preparation</h2> </div> <div class="container-fluid" style="padding-right: 0px;padding-left: 0px;"> <div class="row no-gutters"> <div class="col-md-6"> <a href="https://www.sptlabtech.com/resources/a-closer-look-at-chameleon-providing-rapid-and-efficient-path-to-quality-frozen-grids-for-cryo-em"> <div class="sec5-block mrg-r15"> <img src="https://www.sptlabtech.com/hubfs/SPT%20Labtech%20Website/04%20-%20Structural%20Biology/01%20-%20CryoEM/Cryo-em-Atomic-level-structure-zika-virus%2c.jpg" alt="Cryo-em-Atomic-level-structure-zika-virus," loading="lazy" style="max-width: 100%; height: auto;"> <div class="sec5-text"> Video: A closer look at chameleon - providing a rapid and efficient path to quality frozen grids for cryo-EM </div> </div> </a> </div> <div class="col-md-6"> <a href="https://www.sptlabtech.com/resources/blog-series-summary-sample-preparation-for-single-particle-cryo-em"> <div class="sec5-block mrg-l15"> <img src="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/08%20-%20Blog/researcher-in-cluttered-lab.jpg?width=2000&amp;height=1125&amp;name=researcher-in-cluttered-lab.jpg" alt="researcher-in-cluttered-lab" loading="lazy" width="2000" height="1125" style="max-width: 100%; height: auto;" srcset="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/08%20-%20Blog/researcher-in-cluttered-lab.jpg?width=1000&amp;height=563&amp;name=researcher-in-cluttered-lab.jpg 1000w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/08%20-%20Blog/researcher-in-cluttered-lab.jpg?width=2000&amp;height=1125&amp;name=researcher-in-cluttered-lab.jpg 2000w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/08%20-%20Blog/researcher-in-cluttered-lab.jpg?width=3000&amp;height=1688&amp;name=researcher-in-cluttered-lab.jpg 3000w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/08%20-%20Blog/researcher-in-cluttered-lab.jpg?width=4000&amp;height=2250&amp;name=researcher-in-cluttered-lab.jpg 4000w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/08%20-%20Blog/researcher-in-cluttered-lab.jpg?width=5000&amp;height=2813&amp;name=researcher-in-cluttered-lab.jpg 5000w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/08%20-%20Blog/researcher-in-cluttered-lab.jpg?width=6000&amp;height=3375&amp;name=researcher-in-cluttered-lab.jpg 6000w" sizes="(max-width: 2000px) 100vw, 2000px"> <div class="sec5-text"> Article: Sample Preparation for Single Particle Cryo-EM </div> </div> </a> </div> </div> </div> </div> </div></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-28 main_area-row-8-force-full-width-section dnd-section main_area-row-8-padding"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-29 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1635503809090" 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