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lymphoma</title> <meta name="description" content="Search results for: cutaneous lymphoma"> <meta name="keywords" content="cutaneous lymphoma"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="cutaneous lymphoma"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 172</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: cutaneous lymphoma</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">172</span> Granulomatous Mycoses Fungoides: A Case Report</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Girum%20Tedla%20Assefa">Girum Tedla Assefa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Granulomatous mycosis fungoides is an extremely rare type of cutaneous T-cell lymphoma (<55 cases reported worldwide). Case report: A 36-year-old female presented with soft tissue atrophy of right lower limb (dermis + hypodermis) of 22 years and plaques over trunk of 3 years duration. Histological examination of a biopsy taken from the atrophied tissue showed a granulomatous reaction with epidermotropic atypical lymphocytes. However, in other areas there were only ﬁndings of conventional MF without granuloma. Conclusion: The diagnosis of a granulomatous mycosis fungoides depends exclusively on the histological demonstration of granulomas. Distinct clinical characteristics are not present. This case highlights the importance of thorough investigation of lipoatrophic skin changes in the adult to exclude underlying causes, including MF. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cutaneous%20lymphoma" title="cutaneous lymphoma">cutaneous lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=granulomatous%20skin%20lymphoma" title=" granulomatous skin lymphoma"> granulomatous skin lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=mycoses%20fungoides" title=" mycoses fungoides"> mycoses fungoides</a>, <a href="https://publications.waset.org/abstracts/search?q=skin%20atrophy" title=" skin atrophy"> skin atrophy</a> </p> <a href="https://publications.waset.org/abstracts/34215/granulomatous-mycoses-fungoides-a-case-report" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/34215.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">371</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">171</span> Diagnosis, Treatment, and Prognosis in Cutaneous Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma: A Narrative Review Apropos of a Case</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Laura%20Gleason">Laura Gleason</a>, <a href="https://publications.waset.org/abstracts/search?q=Sahithi%20Talasila"> Sahithi Talasila</a>, <a href="https://publications.waset.org/abstracts/search?q=Lauren%20Banner"> Lauren Banner</a>, <a href="https://publications.waset.org/abstracts/search?q=Ladan%20Afifi"> Ladan Afifi</a>, <a href="https://publications.waset.org/abstracts/search?q=Neda%20Nikbakht"> Neda Nikbakht</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Primary cutaneous anaplastic large cell lymphoma (pcALCL) accounts for 9% of all cutaneous T-cell lymphomas. pcALCL is classically characterized as a solitary papulonodule that often enlarges, ulcerates, and can be locally destructive, but overall exhibits an indolent course with overall 5-year survival estimated to be 90%. Distinguishing pcALCL from systemic ALCL (sALCL) is essential as sALCL confers a poorer prognosis with average 5-year survival being 40-50%. Although extremely rare, there have been several cases of ALK-positive ALCL diagnosed on skin biopsy without evidence of systemic involvement, which poses several challenges in the classification, prognostication, treatment, and follow-up of these patients. Objectives: We present a case of cutaneous ALK-positive ALCL without evidence of systemic involvement, and a narrative review of the literature to further characterize that ALK-positive ALCL limited to the skin is a distinct variant with a unique presentation, history, and prognosis. A 30-year-old woman presented for evaluation of an erythematous-violaceous papule present on her right chest for two months. With the development of multifocal disease and persistent lymphadenopathy, a bone marrow biopsy and lymph node excisional biopsy were performed to assess for systemic disease. Both biopsies were unrevealing. The patient was counseled on pursuing systemic therapy consisting of Brentuximab, Cyclophosphamide, Doxorubicin, and Prednisone given the concern for sALCL. Apropos of the patient we searched for clinically evident, cutaneous ALK-positive ALCL cases, with and without systemic involvement, in the English literature. Risk factors, such as tumor location, number, size, ALK localization, ALK translocations, and recurrence, were evaluated in cases of cutaneous ALK-positive ALCL. The majority of patients with cutaneous ALK-positive ALCL did not progress to systemic disease. The majority of cases that progressed to systemic disease in adults had recurring skin lesions and cytoplasmic localization of ALK. ALK translocations did not influence disease progression. Mean time to disease progression was 16.7 months, and significant mortality (50%) was observed in those cases that progressed to systemic disease. Pediatric cases did not exhibit a trend similar to adult cases. In both the adult and pediatric cases, a subset of cutaneous-limited ALK-positive ALCL were treated with chemotherapy. All cases treated with chemotherapy did not progress to systemic disease. Apropos of an ALK-positive ALCL patient with clinical cutaneous limited disease in the histologic presence of systemic markers, we discussed the literature data, highlighting the crucial issues related to developing a clinical strategy to approach this rare subtype of ALCL. Physicians need to be aware of the overall spectrum of ALCL, including cutaneous limited disease, systemic disease, disease with NPM-ALK translocation, disease with ALK and EMA positivity, and disease with skin recurrence. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anaplastic%20large%20cell%20lymphoma" title="anaplastic large cell lymphoma">anaplastic large cell lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=systemic" title=" systemic"> systemic</a>, <a href="https://publications.waset.org/abstracts/search?q=cutaneous" title=" cutaneous"> cutaneous</a>, <a href="https://publications.waset.org/abstracts/search?q=anaplastic%20lymphoma%20kinase" title=" anaplastic lymphoma kinase"> anaplastic lymphoma kinase</a>, <a href="https://publications.waset.org/abstracts/search?q=ALK" title=" ALK"> ALK</a>, <a href="https://publications.waset.org/abstracts/search?q=ALCL" title=" ALCL"> ALCL</a>, <a href="https://publications.waset.org/abstracts/search?q=sALCL" title=" sALCL"> sALCL</a>, <a href="https://publications.waset.org/abstracts/search?q=pcALCL" title=" pcALCL"> pcALCL</a>, <a href="https://publications.waset.org/abstracts/search?q=cALCL" title=" cALCL"> cALCL</a> </p> <a href="https://publications.waset.org/abstracts/152761/diagnosis-treatment-and-prognosis-in-cutaneous-anaplastic-lymphoma-kinase-positive-anaplastic-large-cell-lymphoma-a-narrative-review-apropos-of-a-case" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/152761.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">83</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">170</span> Plasmablastic Lymphoma a New Entity in Patients with HIV Infections</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rojith%20K.%20Balakrishnan">Rojith K. Balakrishnan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Plasmablastic lymphoma (PBL) is an uncommon, recently described B-cell derived lymphoma that is most commonly seen in patients with Human Immunodeficiency Virus (HIV) infection. Here we report a case of PBL in a 35 year old man with HIV who presented with multiple subcutaneous swellings all over the body and oral mucosal lesions.The biopsy report was suggestive of Diffuse Large B Cell Lymphoma. Immunohistochemistry was done which showed, lymphoma cells, positive for MUM1, CD 138, and VS 38. The proliferation index (MIB) was 95%. Final report was consistent with the diagnosis of Plasmablastic Lymphoma. The lesion completely regressed after treatment with systemic chemotherapy. Up to date, only a few cases of plasmablastic lymphoma have been reported from India. Increased frequency of this lymphoma in HIV patients and rarity of the tumour, along with rapid response of the same to chemotherapy, make this case a unique one. Hence the knowledge about this new entity is important for clinicians who deal with HIV patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=human%20immunodeficiency%20virus%20%28HIV%29" title="human immunodeficiency virus (HIV)">human immunodeficiency virus (HIV)</a>, <a href="https://publications.waset.org/abstracts/search?q=oral%20cavity%20lesion" title=" oral cavity lesion"> oral cavity lesion</a>, <a href="https://publications.waset.org/abstracts/search?q=plasmablastic%20lymphoma" title=" plasmablastic lymphoma"> plasmablastic lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=subcutaneous%20swelling" title=" subcutaneous swelling"> subcutaneous swelling</a> </p> <a href="https://publications.waset.org/abstracts/28672/plasmablastic-lymphoma-a-new-entity-in-patients-with-hiv-infections" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28672.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">274</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">169</span> Study of Non-hodgkin’s Lymphoma</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zidani%20Abla">Zidani Abla</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Lymphoma is a common type of cancer that affects the lymphatic system, including the lymph nodes, spleen and other associated organs. There are two main types of lymphoma: Hodgkin's lymphoma and non-Hodgkin's lymphoma. The epidemiological, clinical and biological features of lymphoma are poorly studied in Algeria. The main objective of our study is to investigate the epidemiological, clinical, paraclinical, etiological, evolutionary and biological characteristics of non-Hodgkin's lymphoma (NHL) in the hematology department of the University Hospital Center (HUC) of Batna. This is a study of 10 patients diagnosed at Batna University Hospital. 70% were male and 30% female (sex ratio M/F= 2.33). Median age was 51.7 years. Pain, especially abdominal pain, was the main reason for consultation. Stage IV predominated (40%), followed by stage III (20%). Abdominal adenopathies (34%) were the most abundant. Secondary hepatic localization was predominant. Large B-cell NHL predominated, accounting for 60% of cases, followed by small B-cell NHL (30%). Serology for hepatitis B and C, and human immunodeficiency virus (HIV) was negative. Biologically, a predominance of hyperleukocytosis, polynuclear neutrophilic leukocytosis, lymphopenia and hypoalbuminemia were present in the majority of cases. In summary, our results remain to be compared with other works for other periods and other regions in order to generalize lymphoma percentages for the entire Algerian population. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=non%20Hodgkin%27s%20lymphoma" title="non Hodgkin's lymphoma">non Hodgkin's lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=epidemiology" title=" epidemiology"> epidemiology</a>, <a href="https://publications.waset.org/abstracts/search?q=clinic" title=" clinic"> clinic</a>, <a href="https://publications.waset.org/abstracts/search?q=biology" title=" biology"> biology</a> </p> <a href="https://publications.waset.org/abstracts/188890/study-of-non-hodgkins-lymphoma" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188890.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">28</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">168</span> Treatment Outcome of Cutaneous Leishmaniasis and Its Associated Factors among Admitted Patients in All Africa Leprosy Rehabilitation and Training Center Hospital, Ethiopia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kebede%20Mairie">Kebede Mairie</a>, <a href="https://publications.waset.org/abstracts/search?q=Getahun%20Belete"> Getahun Belete</a>, <a href="https://publications.waset.org/abstracts/search?q=Mitike%20Abeba"> Mitike Abeba</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Leishmania aethiopica is a peculiar parasite causing cutaneous leishmaniasis in Ethiopia and its mainstay treatment is Sodium Stibogluconate. However, its treatment outcome in Ethiopia is not well documented. Objectives: To determine the treatment outcome of admitted cutaneous leishmaniasis patients and its associated factors in Addis Ababa, Ethiopia. Methods: A retrospective study was conducted from 1st November 2021 to 30th March 2022. Medical records of all cutaneous leishmaniasis-diagnosed and admitted patients who received parenteral sodium stibogluconate at All Africa Leprosy Rehabilitation and Training Center (ALERT) hospital, the main Leishmania treatment center in Ethiopia from July 2011 to September 2021 were reviewed. Results: A total of 827 charts of admitted cases from July 2011 to September 2021 were retrieved, but 667 (80.65%) were reviewed. Improvement in the treatment outcome was recorded in 93.36 % in the first course of SSG treatment and 96.23%, 94.62%, and 96.97% subsequently in the second, third and fourth treatment courses, respectively. Female gender and diffuse cutaneous leishmaniasis were the two predictive determinants in the treatment of cutaneous leishmaniasis. Conclusion: The study shows that parenteral sodium stibogluconate therapy treats hospitalized cutaneous leishmaniasis patients well, with female gender and diffuse cutaneous leishmaniasis having poor outcomes suggesting the need for a different approach for diffuse cutaneous leishmaniasis patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cutaneous%20leishmaniasis" title="cutaneous leishmaniasis">cutaneous leishmaniasis</a>, <a href="https://publications.waset.org/abstracts/search?q=leishmania%20aethiopica" title=" leishmania aethiopica"> leishmania aethiopica</a>, <a href="https://publications.waset.org/abstracts/search?q=sodium%20stibogluconate" title=" sodium stibogluconate"> sodium stibogluconate</a>, <a href="https://publications.waset.org/abstracts/search?q=diffuse%20cutaneous%20leishmaniasis" title=" diffuse cutaneous leishmaniasis"> diffuse cutaneous leishmaniasis</a>, <a href="https://publications.waset.org/abstracts/search?q=pentostam" title=" pentostam"> pentostam</a> </p> <a href="https://publications.waset.org/abstracts/164278/treatment-outcome-of-cutaneous-leishmaniasis-and-its-associated-factors-among-admitted-patients-in-all-africa-leprosy-rehabilitation-and-training-center-hospital-ethiopia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/164278.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">77</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">167</span> The Clinical and Survival Differences between Primary B-Cell and T/NK-Cell Non-Hodgkin Lymphomas in the Nasopharynx, Nasal Cavity, and Nasal Sinus: A Population-Based Study of 3839 Cases in the Seer Database</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jiajia%20Peng">Jiajia Peng</a>, <a href="https://publications.waset.org/abstracts/search?q=Danni%20Cheng"> Danni Cheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianqing%20Qiu"> Jianqing Qiu</a>, <a href="https://publications.waset.org/abstracts/search?q=Yufang%20Rao"> Yufang Rao</a>, <a href="https://publications.waset.org/abstracts/search?q=Minzi%20Mao"> Minzi Mao</a>, <a href="https://publications.waset.org/abstracts/search?q=Ke%20Qiu"> Ke Qiu</a>, <a href="https://publications.waset.org/abstracts/search?q=Junhong%20Li"> Junhong Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Fei%20Chen"> Fei Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Feng%20Liu"> Feng Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Jun%20Liu"> Jun Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Xiaosong%20Mu"> Xiaosong Mu</a>, <a href="https://publications.waset.org/abstracts/search?q=Wenxin%20Yu"> Wenxin Yu</a>, <a href="https://publications.waset.org/abstracts/search?q=Wei%20Zhang"> Wei Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Wei%20Xu"> Wei Xu</a>, <a href="https://publications.waset.org/abstracts/search?q=Yu%20Zhao"> Yu Zhao</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianjun%20Ren"> Jianjun Ren</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Currently, primary B-cell non-Hodgkin lymphoma (B-NHL) and T/NK-cell non-Hodgkin lymphoma (NKT-NHL) originated from the nasal cavity (NC), nasopharynx (NP) and nasal sinus (NS) distinguished unclearly in the clinic. Objective: We sought to compare the clinical and survival differences of B-NHL and NKT-NHL that occurred in NC, NP, and NS, respectively. Methods: Retrospective data of patients diagnosed with nasal cavity lymphoma (NCL), nasopharyngeal lymphoma (NPL), and nasal sinus lymphoma (NSL) between 1975 and 2017 from the Surveillance, Epidemiology, and End Results (SEER) database were collected. We identified the B/NKT-NHL patients based on the histological type and performed univariate, multivariate, and Kaplan-Meier analyses to investigate the survival rates. Results: Of the identified 3,101 B-NHL and 738 NKT-NHL patients, those with B-NHL in NP were the majority (43%) and had better cancer-specific survival than those in NC and NS from 2010 to 2017 (5-year-CSS, NC vs. NP vs. NS: 81% vs. 83% vs. 82%). In contrast, most of the NKT-NHL originated from NC (68%) and had the highest CSS rate in the recent seven years (2010-2017, 5-year-CSS: 63%). Additionally, the survival outcomes of patients with NKT-NHL-NP (HR: 1.34, 95% CI: 0.62-2.89, P=0.460) who had received surgery were much worse than those of patients with NKT-NHL-NC (HR: 1.07, 95% CI: 0.75-1.52, P=0.710) and NKT-NHL-NS (HR: 1.11, 95% CI: 0.59-2.07, P=0.740). NKT-NHL-NS patients who had radiation performed (HR: 0.38, 95% CI: 0.19-0.73, P=0.004) showed the highest survival rates, while chemotherapy performed (HR: 1.01, 95% CI: 0.43-2.37, P=0.980) presented opposite results. Conclusions: Although B-NHL and NKT-NHL originating from NC, NP and NS had similar anatomical locations, their clinical characteristics, treatment therapies, and prognoses were different in this study. Our findings may suggest that B-NHL and NKT-NHL in NC, NP, and NS should be treated as different diseases in the clinic. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nasopharyngeal%20lymphoma" title="nasopharyngeal lymphoma">nasopharyngeal lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=nasal%20cavity%20lymphoma" title=" nasal cavity lymphoma"> nasal cavity lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=nasal%20sinus%20lymphoma" title=" nasal sinus lymphoma"> nasal sinus lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=B-cell%20non-Hodgkin%20lymphoma" title=" B-cell non-Hodgkin lymphoma"> B-cell non-Hodgkin lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=T%2FNK-cell%20non-Hodgkin%20lymphoma" title=" T/NK-cell non-Hodgkin lymphoma"> T/NK-cell non-Hodgkin lymphoma</a> </p> <a href="https://publications.waset.org/abstracts/144875/the-clinical-and-survival-differences-between-primary-b-cell-and-tnk-cell-non-hodgkin-lymphomas-in-the-nasopharynx-nasal-cavity-and-nasal-sinus-a-population-based-study-of-3839-cases-in-the-seer-database" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/144875.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">184</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">166</span> Non-AIDS Related Multiple Brain and Orbital Lymphoma Mimicking Meningioma: A Case Report</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Eghosa%20Morgan">Eghosa Morgan</a>, <a href="https://publications.waset.org/abstracts/search?q=Bourtarbouch%20Mahjouba"> Bourtarbouch Mahjouba</a>, <a href="https://publications.waset.org/abstracts/search?q=Heida%20El%20Ouahabi"> Heida El Ouahabi</a>, <a href="https://publications.waset.org/abstracts/search?q=Poluyi%20Edward"> Poluyi Edward</a>, <a href="https://publications.waset.org/abstracts/search?q=Diawarra%20Seylan"> Diawarra Seylan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Non-AIDS lymphoma, a type of primary central nervous system (CNS) lymphoma is an uncommon aggressive infiltrative malignant tumour involving several sites in the central nervous system, such as the periventricular region and leptomeninges. In this article, the authors presented a 26-year old man with painless progressive right exophthalmos and scalp swelling with no symptoms and signs of intracranial hypertension and hyperthyroidism. Magnetic resonance imaging (MRI) done revealed isointense masses with brilliant homogenous enhancement on contrast administration resembling a meningioma, with a dura tail – like attachment as seen in meningioma. He had surgery for the right orbital tumour and histopathological diagnosis confirmed our suspicion of lymphoma (B type). Steroid was given in the post-operative period which led to significant regression of the tumours, hence its description as ‘vanishing tumour’. He is presently receiving methotrexate-based chemotherapy and subsequently planned for radiotherapy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=central%20nervous%20system%20%28CNS%29" title="central nervous system (CNS)">central nervous system (CNS)</a>, <a href="https://publications.waset.org/abstracts/search?q=meningioma" title=" meningioma"> meningioma</a>, <a href="https://publications.waset.org/abstracts/search?q=non-aids%20lymphoma" title=" non-aids lymphoma"> non-aids lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=orbital" title=" orbital"> orbital</a> </p> <a href="https://publications.waset.org/abstracts/153811/non-aids-related-multiple-brain-and-orbital-lymphoma-mimicking-meningioma-a-case-report" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/153811.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">91</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">165</span> Incidence of Lymphoma and Gonorrhea Infection: A Retrospective Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Diya%20Kohli">Diya Kohli</a>, <a href="https://publications.waset.org/abstracts/search?q=Amalia%20Ardeljan"> Amalia Ardeljan</a>, <a href="https://publications.waset.org/abstracts/search?q=Lexi%20Frankel"> Lexi Frankel</a>, <a href="https://publications.waset.org/abstracts/search?q=Jose%20Garcia"> Jose Garcia</a>, <a href="https://publications.waset.org/abstracts/search?q=Lokesh%20Manjani"> Lokesh Manjani</a>, <a href="https://publications.waset.org/abstracts/search?q=Omar%20Rashid"> Omar Rashid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Gonorrhea is the second most common sexually transmitted disease (STDs) in the United States of America. Gonorrhea affects the urethra, rectum, or throat and the cervix in females. Lymphoma is a cancer of the immune network called the lymphatic system that includes the lymph nodes/glands, spleen, thymus gland, and bone marrow. Lymphoma can affect many organs in the body. When a lymphocyte develops a genetic mutation, it signals other cells into rapid proliferation that causes many mutated lymphocytes. Multiple studies have explored the incidence of cancer in people infected with STDs such as Gonorrhea. For instance, the studies conducted by Wang Y-C and Co., as well as Caini, S and Co. established a direct co-relationship between Gonorrhea infection and incidence of prostate cancer. We hypothesize that Gonorrhea infection also increases the incidence of Lymphoma in patients. This research study aimed to evaluate the correlation between Gonorrhea infection and the incidence of Lymphoma. The data for the research was provided by a Health Insurance Portability and Accountability Act (HIPAA) compliant national database. This database was utilized to evaluate patients infected with Gonorrhea versus the ones who were not infected to establish a correlation with the prevalence of Lymphoma using ICD-10 and ICD-9 codes. Access to the database was granted by the Holy Cross Health, Fort Lauderdale for academic research. Standard statistical methods were applied throughout. Between January 2010 and December 2019, the query was analyzed and resulted in 254 and 808 patients in both the infected and control group, respectively. The two groups were matched by Age Range and CCI score. The incidence of Lymphoma was 0.998% (254 patients out of 25455) in the Gonorrhea group (patients infected with Gonorrhea that was Lymphoma Positive) compared to 3.174% and 808 patients in the control group (Patients negative for Gonorrhea but with Lymphoma). This was statistically significant by a p-value < 2.210-16 with an OR= 0.431 (95% CI 0.381-0.487). The patients were then matched by antibiotic treatment to avoid treatment bias. The incidence of Lymphoma was 1.215% (82 patients out of 6,748) in the Gonorrhea group compared to 2.949% (199 patients out of 6748) in the control group. This was statistically significant by a p-value <5.410-10 with an OR= 0.468 (95% CI 0.367-0.596). The study shows a statistically significant correlation between Gonorrhea and a reduced incidence of Lymphoma. Further evaluation is recommended to assess the potential of Gonorrhea in reducing Lymphoma. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gonorrhea" title="gonorrhea">gonorrhea</a>, <a href="https://publications.waset.org/abstracts/search?q=lymphoma" title=" lymphoma"> lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=STDs" title=" STDs"> STDs</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer" title=" cancer"> cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=ICD" title=" ICD"> ICD</a> </p> <a href="https://publications.waset.org/abstracts/140202/incidence-of-lymphoma-and-gonorrhea-infection-a-retrospective-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/140202.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">195</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">164</span> Cutaneous Crohn’s Disease in a Child: Atypical Axillary Involvement</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20Al%20Yousef">A. Al Yousef</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Toulon"> A. Toulon</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20Petit"> L. Petit</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Fraitag"> S. Fraitag</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Ruemmele"> F. Ruemmele</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Hadj-Rabia"> S. Hadj-Rabia</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Bodemer"> C. Bodemer</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cutaneous Crohn’s disease (CCD) refers to an extremely rare granulomatous inflammation of the skin that is non-contiguous to the bowel tract. These cutaneous lesions can occur prior to, concurrent with, or after the gastrointestinal manifestations. In adults, CCD most frequently occurs in the setting of well-documented intestinal disease. Only 20% of cases occur prior to its development. Review of CCD in children, reveals that 86% of cases (24 of 28) occurring in patients without a known diagnosis of intestinal Crohn’s disease. Overall, the genitalia was the most commonly involved location, representing 21 of the 28 cases with 16 vulvar and 5 penile/scrotal lesions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Crohn%E2%80%99s%20disease" title="Crohn’s disease">Crohn’s disease</a>, <a href="https://publications.waset.org/abstracts/search?q=cutaneous%20manifestations" title=" cutaneous manifestations"> cutaneous manifestations</a>, <a href="https://publications.waset.org/abstracts/search?q=children" title=" children"> children</a>, <a href="https://publications.waset.org/abstracts/search?q=atypical%20axillary%20involvement" title=" atypical axillary involvement"> atypical axillary involvement</a> </p> <a href="https://publications.waset.org/abstracts/16760/cutaneous-crohns-disease-in-a-child-atypical-axillary-involvement" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16760.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">282</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">163</span> The Role Previous Cytomegalovirus Infection in Subsequent Lymphoma Develompment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amalia%20Ardeljan">Amalia Ardeljan</a>, <a href="https://publications.waset.org/abstracts/search?q=Lexi%20Frankel"> Lexi Frankel</a>, <a href="https://publications.waset.org/abstracts/search?q=Divesh%20Manjani"> Divesh Manjani</a>, <a href="https://publications.waset.org/abstracts/search?q=Gabriela%20Santizo"> Gabriela Santizo</a>, <a href="https://publications.waset.org/abstracts/search?q=Maximillian%20Guerra"> Maximillian Guerra</a>, <a href="https://publications.waset.org/abstracts/search?q=Omar%20Rashid"> Omar Rashid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Cytomegalovirus (CMV) infection is a widespread infection affecting between 60-70% of people in industrialized countries. CMV has been previously correlated with a higher incidence of Hodgkin Lymphoma compared to noninfected persons. Research regarding prior CMV infection and subsequent lymphoma development is still controversial. With limited evidence, further research is needed in order to understand the relationship between previous CMV infection and subsequent lymphoma development. This study assessed the effect of CMV infection and the incidence of lymphoma afterward. Methods: A retrospective cohort study (2010-2019) was conducted through a Health Insurance Portability and Accountability Act (HIPAA) compliant national database and conducted using International Classification of Disease (ICD) 9th,10th codes, and Current Procedural Terminology (CPT) codes. These were used to identify lymphoma diagnosis in a previously CMV infected population. Patients were matched for age range and Charlson Comorbidity Index (CCI). A chi-squared test was used to assess statistical significance. Results: A total number of 14,303 patients was obtained in the CMV infected group as well as in the control population (matched by age range and CCI score). Subsequent lymphoma development was seen at a rate of 11.44% (1,637) in the CMV group and 5.74% (822) in the control group, respectively. The difference was statistically significant by p= 2.2x10-16, odds ratio = 2.696 (95% CI 2.483- 2.927). In an attempt to stratify the population by antiviral medication exposure, the outcomes were limited by the decreased number of members exposed to antiviral medication in the control population. Conclusion: This study shows a statistically significant correlation between prior CMV infection and an increased incidence of lymphoma afterward. Further exploration is needed to identify the potential carcinogenic mechanism of CMV and whether the results are attributed to a confounding bias. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cytomegalovirus" title="cytomegalovirus">cytomegalovirus</a>, <a href="https://publications.waset.org/abstracts/search?q=lymphoma" title=" lymphoma"> lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer" title=" cancer"> cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=microbiology" title=" microbiology"> microbiology</a> </p> <a href="https://publications.waset.org/abstracts/140178/the-role-previous-cytomegalovirus-infection-in-subsequent-lymphoma-develompment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/140178.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">219</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">162</span> Isolation, Screening and Identification of Frog Cutaneous Bacteria for Anti-Batrachochytrium dendrobatidis Activity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Adria%20Rae%20Abigail%20R.%20Eda">Adria Rae Abigail R. Eda</a>, <a href="https://publications.waset.org/abstracts/search?q=Arvin%20C.%20Diesmos"> Arvin C. Diesmos</a>, <a href="https://publications.waset.org/abstracts/search?q=Vance%20T.%20Vredenburg"> Vance T. Vredenburg</a>, <a href="https://publications.waset.org/abstracts/search?q=Merab%20A.%20Chan"> Merab A. Chan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Mitigating strategies using symbiotic cutaneous bacteria is one of the major concerns in the conservation of amphibian population. Batrachochytrium dendrobatidis is the causative agent of chytridiomycosis associated with mass mortality and amphibian extinctions worldwide. In the Philippines, there is a lack of study on the cutaneous bacteria of Philippine amphibians that may have beneficial effects to ward off the deadly fungal infection. In this study, cutaneous bacteria from frogs were isolated and examined for anti-B. dendrobatidis activity. Eight species of frogs were collected at Mt. Palay-palay Mataas na Gulod National Park in Cavite, a site positive for the presence of B. dendrobatidis. Bacteria were isolated from the skin of frogs by swabbing the surfaces of the body and inoculated in Reasoner´s 2A (R2A) agar. Isolated bacteria were tested for potential inhibitory properties against B. dendrobatidis through zoospore inhibition assay. Results showed that frog cutaneous bacteria significantly inhibited the growth of B. dendrobatidis in vitro. By means of 16S rRNA gene primers, the anti-B. dendrobatidis bacteria were identified to be Enterobacter sp., Alcaligenes faecalis and Pseudomonas sp. Cutaneous bacteria namely Enterobacter sp. (isolates PLd33 and PCv4) and Pseudomonas (isolate PLd31) remarkably cleared the growth of B. dendrobatidis zoospore in 1% tryptone agar. Therefore, frog cutaneous bacteria inhibited B. dendrobatidis in vitro and could possibly contribute to the immunity and defense of frogs against the lethal chytridiomycosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Batrachochytrium%20dendrobatidis" title="Batrachochytrium dendrobatidis">Batrachochytrium dendrobatidis</a>, <a href="https://publications.waset.org/abstracts/search?q=cutaneous%20bacteria" title=" cutaneous bacteria"> cutaneous bacteria</a>, <a href="https://publications.waset.org/abstracts/search?q=frogs" title=" frogs"> frogs</a>, <a href="https://publications.waset.org/abstracts/search?q=zoospore%20inhibition%20assay" title=" zoospore inhibition assay"> zoospore inhibition assay</a> </p> <a href="https://publications.waset.org/abstracts/21413/isolation-screening-and-identification-of-frog-cutaneous-bacteria-for-anti-batrachochytrium-dendrobatidis-activity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21413.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">454</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">161</span> Oxidative Antioxidative Status and DNA Damage Profile Induced by Chemotherapy in Algerian Children with Lymphoma</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Assia%20Galleze">Assia Galleze</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdurrahim%20Kocyigit"> Abdurrahim Kocyigit</a>, <a href="https://publications.waset.org/abstracts/search?q=Nacira%20%20Cherif"> Nacira Cherif</a>, <a href="https://publications.waset.org/abstracts/search?q=Nidel%20Benhalilou"> Nidel Benhalilou</a>, <a href="https://publications.waset.org/abstracts/search?q=Nabila%20Attal"> Nabila Attal</a>, <a href="https://publications.waset.org/abstracts/search?q=Chafia%20Touil%20Boukkoffa"> Chafia Touil Boukkoffa</a>, <a href="https://publications.waset.org/abstracts/search?q=Rachida%20Raache"> Rachida Raache</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction and aims: Chemotherapeutic agents used to inhibit cell division and reduce tumor growth, increase reactive oxygen species levels, which contributes to their genotoxicity [1]. The comet assay is an inexpensive and rapid method to detect the damage at cellular levels and has been used in various cancer populations undergoing chemotherapy [2,3]. The present study aim to assess the oxidative stress and the genotoxicity induced by chemotherapy by the determination of plasma malondialdehyde (MDA) level, protein carbonyl (PC) content, superoxide dismutase (SOD) activity and lymphocyte DNA damage in Algerian children with lymphoma. Materials and Methods: For our study, we selected thirty children with lymphoma treated in university hospital of Beni Messous, Algeria, and fifty unrelated subjects as controls, after obtaining the informed consent in accordance with the Declaration of Helsinki (1964). Plasma levels of MDA, PC and SOD activity were spectrophotometrically measured, while DNA damage was assessed by alkaline comet assay in peripheral blood leukocytes. Results and Discussion: Plasma MDA, PC levels and lymphocyte DNA damage, were found to be significantly higher in lymphoma patients than in controls (p < 0.001). Whereas, SOD activity in lymphoma patients was significantly lower than in healthy controls (p < 0.001). There were significant positive correlations between DNA damage, MDA and PC in patients (r = 0.96, p < 0.001, r = 0.97, p < 0.001, respectively), and negative correlation with SOD (r = 0.87, p < 0.01). Conclusion and Perspective: Our results indicated that, leukocytes DNA damage and oxidative stress were significantly higher in lymphoma patients, suggesting that the direct effect of chemotherapy and the alteration of the redox balance may influence oxidative/antioxidative status. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chemotherapy" title="chemotherapy">chemotherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=comet%20assay" title=" comet assay"> comet assay</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA%20damage" title=" DNA damage"> DNA damage</a>, <a href="https://publications.waset.org/abstracts/search?q=lymphoma" title=" lymphoma"> lymphoma</a> </p> <a href="https://publications.waset.org/abstracts/124329/oxidative-antioxidative-status-and-dna-damage-profile-induced-by-chemotherapy-in-algerian-children-with-lymphoma" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/124329.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">137</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">160</span> Lymphomas as Estrogen-Regulated Cancers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20S.%20Hasni">M. S. Hasni</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20Guan"> J. Guan</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Yakimchuk"> K. Yakimchuk</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Berglund"> M. Berglund</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20Sander"> B. Sander</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20Enblad"> G. Enblad</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20M.%20Amini"> R. M. Amini</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Okret"> S. Okret</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Lymphomas are generally not considered as endocrine-related cancers. However, most lymphoid malignancies show gender differences in incidence and show prognosis with males being more affected. Furthermore, some epidemiological data indicate a protective role of estrogens against Non-Hodgkin lymphomas. Recent studies have demonstrated estrogen receptor β (ERβ) to be the major ER expressed in normal and malignant cells of lymphoid origin. We have analyzed the effects of estradiol and selective ERα and ERβ agonists on lymphoma growth in culture and in vivo. Treating lymphoma cells with estradiol or ERα selective agonist had minor or no effect on cell growth while selective ERβ agonist treatment showed an antiproliferative effect. When grafting mice with murine T lymphoma cells, male mice developed larger tumors compared to female mice, a difference that was abolished following ovariectomy, demonstrating estrogen-dependent growth in vivo. When subcutaneously grafting lymphoma cells to mice, so far growth of all tested human B lymphoma tumors (Raji and Ramos Burkitt lymphoma, SU.DHL4 (GC) and U2932 (ABC) DLBCL, Granta-519, Maver1 and Z138 MCL cells), were reduced following treatment with ERβ selective agonist (ref. 2 and unpublished). Moreover, the number and size of liver foci of disseminating Raji cells was reduced. We have identified target genes and mechanism that could explain the above effects of ERβ agonists. This included effects on angio and lymphangiogenesis. Now we have further analyzed effects of ERβ agonists on Ibrutinib-sensitive and -insensitive MCL cells in xenograft experiments as well as ERβ expression in primary lymphoma material (DLBCL). Preliminary statistical analysis has been done correlating ERβ expression to other biomarkers and clinical data. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lymphomas" title="lymphomas">lymphomas</a>, <a href="https://publications.waset.org/abstracts/search?q=estrogen%20receptors" title=" estrogen receptors"> estrogen receptors</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer" title=" cancer"> cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20foci" title=" liver foci"> liver foci</a> </p> <a href="https://publications.waset.org/abstracts/17116/lymphomas-as-estrogen-regulated-cancers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17116.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">411</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">159</span> Epidemiology of Cutaneous Malignant Melanoma in Pakistan: Incidence, Clinical Subtypes, Tumor Stage and Localization</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Warda%20Jabeen">Warda Jabeen</a>, <a href="https://publications.waset.org/abstracts/search?q=Romaisa%20Shamim%20Khan"> Romaisa Shamim Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Osama%20Shakeel"> Osama Shakeel</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20Faraz%20Bhatti"> Ahmed Faraz Bhatti</a>, <a href="https://publications.waset.org/abstracts/search?q=Raza%20Hussain"> Raza Hussain</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: The worldwide incidence of cutaneous melanoma (CM) has been on the rise over the past few decades. Primary prevention and early treatment remain the focus of management to reduce the burden of disease. This entails identification of risk factors to prompt early diagnosis. In Pakistan, there is a scarcity of clinico-pathological data relating to cutaneous malignant melanoma. Objective: The purpose of this study was to analyze the epidemiological and clinical characteristics of patients presenting with cutaneous malignant melanoma in Pakistan, and to compare the results with other studies. Method: Shaukat Khanum Memorial Cancer Hospital and Research Centre is currently the only dedicated cancer hospital in the country, accepting patients from all over Pakistan. Majority of the patients, however, belong to the northern half of the country. From the recorded data of the hospital, all cutaneous melanoma cases were identified and evaluated. Results: Between 1997 and 2017, a total of 169 cutaneous melanoma patients were registered at Shaukat Khanum. Mean age was 47.5 years. The highest incidence of melanoma was seen in the age group 40-59 years (n=69, 40.8%). Most commonly reported clinical subtype was unspecified melanoma (n=154, 91%). Amongst those in which T stage was reported, the most frequently observed T-stage at presentation was T4 (n=23, 13.6%). With regards to body distribution, in our study CM was seen most commonly in the lower limb including the hip. The yearly incidence of melanoma has increased/remained stable from 2007 to 2017. Conclusion: cutaneous malignant melanoma is a fairly common disease in Pakistan. Patients tend to present at a more advanced stage as compared to patients in developed countries. Identification of risk factors and tumor characteristics is therefore of paramount importance to deal with these patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=epidemiology%20of%20cutaneous%20malignant%20melanoma" title="epidemiology of cutaneous malignant melanoma">epidemiology of cutaneous malignant melanoma</a>, <a href="https://publications.waset.org/abstracts/search?q=cutaneous%20malignant%20melanoma" title=" cutaneous malignant melanoma"> cutaneous malignant melanoma</a>, <a href="https://publications.waset.org/abstracts/search?q=Pakistan" title=" Pakistan"> Pakistan</a>, <a href="https://publications.waset.org/abstracts/search?q=skin%20cancer" title=" skin cancer"> skin cancer</a> </p> <a href="https://publications.waset.org/abstracts/101508/epidemiology-of-cutaneous-malignant-melanoma-in-pakistan-incidence-clinical-subtypes-tumor-stage-and-localization" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/101508.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">136</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">158</span> Separation, Identification, and Measuring Gossypol in the Cottonseed Oil and Investigating the Performance of Drugs Prepared from the Combination of Plant Extract and Oil in the Treatment of Cutaneous Leishmaniasis Resistant to Drugs</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sara%20Taghdisi">Sara Taghdisi</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Mirmohammadi"> M. Mirmohammadi</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Mokhtarian"> M. Mokhtarian</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In 2013, the World Health Organization announced the cases of Cutaneous leishmaniasis infection in Iran between 69,000 to 113,000. The most common chemical drugs for Cutaneous leishmaniasis treatment are sodium stibogluconate, and meglumine antimonate, which not only have relatively many side effects, but also some species of the Leishmania genus have become resistant to them .The most prominent compound existing in different parts of the cotton plant is a yellow polyphenol called Gossypol. Gossypol is an extremely valuable compound and has anti-cancer properties. In the current project, Gossypol was extracted with a liquid-liquid extraction method in 120 minutes in the presence of Phosphoric acid from the cotton seed oil of Golestan beach varieties, then got crystallized in darkness using Acetic acid and isolated as Gossypol Acetic acid. The efficiency of the extracted crystal was obtained at 0.12+- 1.28. the cotton plant could be efficient in the treatment of Cutaneous leishmaniasis. The extract of the green-leaf cotton boll of Jargoyeh varieties was tested as an ointment on the target group of patients suffering from Cutaneous leishmaniasis resistant to drugs esistant to drugs by our colleagues in the research team. The results showed the Pearson's correlation coefficient of 0.72 between the two variables of wound diameter and the extract use over time which indicated the positive effect of this extract on the treatment of Cutaneous leishmaniasis was resistant to drugs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cottonseed%20oil" title="cottonseed oil">cottonseed oil</a>, <a href="https://publications.waset.org/abstracts/search?q=crystallization" title=" crystallization"> crystallization</a>, <a href="https://publications.waset.org/abstracts/search?q=gossypol" title=" gossypol"> gossypol</a>, <a href="https://publications.waset.org/abstracts/search?q=green-leaf" title=" green-leaf"> green-leaf</a> </p> <a href="https://publications.waset.org/abstracts/170536/separation-identification-and-measuring-gossypol-in-the-cottonseed-oil-and-investigating-the-performance-of-drugs-prepared-from-the-combination-of-plant-extract-and-oil-in-the-treatment-of-cutaneous-leishmaniasis-resistant-to-drugs" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170536.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">109</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">157</span> Assessment of Isatin as Surface Recognition Group: Design, Synthesis and Anticancer Evaluation of Hydroxamates as Novel Histone Deacetylase Inhibitors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Harish%20Rajak">Harish Rajak</a>, <a href="https://publications.waset.org/abstracts/search?q=Kamlesh%20Raghuwanshi"> Kamlesh Raghuwanshi </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Histone deacetylase (HDAC) are promising target for cancer treatment. The panobinostat (Farydak; Novartis; approved by USFDA in 2015) and chidamide (Epidaza; Chipscreen Biosciences; approved by China FDA in 2014) are the novel HDAC inhibitors ratified for the treatment of patients with multiple myeloma and peripheral T cell lymphoma, respectively. On the other hand, two other HDAC inhibitors, Vorinostat (SAHA; approved by USFDA in 2006) and Romidepsin (FK228; approved by USFDA in 2009) are already in market for the treatment of cutaneous T-cell lymphoma. Several hydroxamic acid based HDAC inhibitors i.e., belinostat, givinostat, PCI24781 and JNJ26481585 are in clinical trials. HDAC inhibitors consist of three pharmacophoric features - an aromatic cap group, zinc binding group (ZBG) and a linker chain connecting cap group to ZBG. Herein, we report synthesis, characterization and biological evaluation of HDAC inhibitors possessing substituted isatin moiety as cap group which recognize the surface of active enzyme pocket and thiosemicarbazide moiety incorporated as linker group responsible for connecting cap group to ZBG (hydroxamic acid). Several analogues were found to inhibit HDAC and cellular proliferation of Hela cervical cancer cells with GI50 values in the micro molar range. Some of the compounds exhibited promising results in vitro antiproliferative studies. Attempts were also made to establish the structure activity relationship among synthesized HDAC inhibitors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=HDAC%20inhibitors" title="HDAC inhibitors">HDAC inhibitors</a>, <a href="https://publications.waset.org/abstracts/search?q=hydroxamic%20acid%20derivatives" title=" hydroxamic acid derivatives"> hydroxamic acid derivatives</a>, <a href="https://publications.waset.org/abstracts/search?q=isatin%20derivatives" title=" isatin derivatives"> isatin derivatives</a>, <a href="https://publications.waset.org/abstracts/search?q=antiproliferative%20%09%09%09activity" title=" antiproliferative activity"> antiproliferative activity</a>, <a href="https://publications.waset.org/abstracts/search?q=docking" title=" docking"> docking</a> </p> <a href="https://publications.waset.org/abstracts/40759/assessment-of-isatin-as-surface-recognition-group-design-synthesis-and-anticancer-evaluation-of-hydroxamates-as-novel-histone-deacetylase-inhibitors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40759.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">307</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">156</span> Principle Component Analysis on Colon Cancer Detection</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=N.%20K.%20Caecar%20Pratiwi">N. K. Caecar Pratiwi</a>, <a href="https://publications.waset.org/abstracts/search?q=Yunendah%20Nur%20Fuadah"> Yunendah Nur Fuadah</a>, <a href="https://publications.waset.org/abstracts/search?q=Rita%20Magdalena"> Rita Magdalena</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20D.%20Atmaja"> R. D. Atmaja</a>, <a href="https://publications.waset.org/abstracts/search?q=Sofia%20Saidah"> Sofia Saidah</a>, <a href="https://publications.waset.org/abstracts/search?q=Ocky%20Tiaramukti"> Ocky Tiaramukti</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Colon cancer or colorectal cancer is a type of cancer that attacks the last part of the human digestive system. Lymphoma and carcinoma are types of cancer that attack human’s colon. Colon cancer causes deaths about half a million people every year. In Indonesia, colon cancer is the third largest cancer case for women and second in men. Unhealthy lifestyles such as minimum consumption of fiber, rarely exercising and lack of awareness for early detection are factors that cause high cases of colon cancer. The aim of this project is to produce a system that can detect and classify images into type of colon cancer lymphoma, carcinoma, or normal. The designed system used 198 data colon cancer tissue pathology, consist of 66 images for Lymphoma cancer, 66 images for carcinoma cancer and 66 for normal / healthy colon condition. This system will classify colon cancer starting from image preprocessing, feature extraction using Principal Component Analysis (PCA) and classification using K-Nearest Neighbor (K-NN) method. Several stages in preprocessing are resize, convert RGB image to grayscale, edge detection and last, histogram equalization. Tests will be done by trying some K-NN input parameter setting. The result of this project is an image processing system that can detect and classify the type of colon cancer with high accuracy and low computation time. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carcinoma" title="carcinoma">carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=colorectal%20cancer" title=" colorectal cancer"> colorectal cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=k-nearest%20neighbor" title=" k-nearest neighbor"> k-nearest neighbor</a>, <a href="https://publications.waset.org/abstracts/search?q=lymphoma" title=" lymphoma"> lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=principle%20component%20analysis" title=" principle component analysis"> principle component analysis</a> </p> <a href="https://publications.waset.org/abstracts/105607/principle-component-analysis-on-colon-cancer-detection" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/105607.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">205</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">155</span> A Case of Mantle Cell Lymphoma Presenting With GI Symptoms and Noted to Have Extranodal Involvement of the Stomach and Colon on Presentation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Saba%20Amreen%20Syeda">Saba Amreen Syeda</a>, <a href="https://publications.waset.org/abstracts/search?q=Summaiah%20Asim"> Summaiah Asim</a>, <a href="https://publications.waset.org/abstracts/search?q=Syeda"> Syeda</a>, <a href="https://publications.waset.org/abstracts/search?q=Hafsa"> Hafsa</a>, <a href="https://publications.waset.org/abstracts/search?q=Essam%20Quraishi"> Essam Quraishi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Mantle Cell Lymphoma (MCL) is a relatively uncommon type of lymphoma that comprises approximately 7 percent of non hodgkin's lymphomas (NHL), Classic MCL presents mostly in lymph nodes and occasionally in extranodal sites. About 26 % of MCL is present primarily in the Gastrointestinal tract. While both the upper GI tract and the lower GI tract could be involved, it is rare to present with concurrent upper and lower GI involvement with MCL. We present the case of a 51-year-old Asian Indian male that presented to our clinic with complaints of chronic diarrhea for the last one year, progressively worsening over the past three months. The Patient also reported black stool as well as bright red blood per rectum. Patient reported severe fatigue on minimal exertion. On a physical exam, the patient was noted to have matted lymphadenopathy in the neck. Patient was noted to be anemic with a hemoglobin to be 8 g/dl. Esophagogastroduodenoscopy and colonoscopy was performed. EGD showed a large 4 cm ulcer in the gastric antrum with thick heaped up edges. There was bleeding on contact. Colonoscopy showed a large 35 mm multilobulated polyp in the ascending colon, which was biopsied. The patient was also noted to have nodular proctitis in the mid rectum. This was localized and extended to about 5 cm. This area was biopsied as well. Biopsies from the stomach, colon, as well as the rectum, returned with findings of mantle cell lymphoma on pathology. Lymphoid cells in the biopsy were stained strongly positive for CD 20, cyclin D1, and CD 5. There was the absence of stain for CD 3 and CD 10. The IHC stain for CD 23 was negative. Biopsies from neck LAD were obtained and were also positive for MCL. The patient was referred to oncology for staging and treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mantle%20cell%20lymphoma" title="mantle cell lymphoma">mantle cell lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=GI%20bleed" title=" GI bleed"> GI bleed</a>, <a href="https://publications.waset.org/abstracts/search?q=diarrhea" title=" diarrhea"> diarrhea</a>, <a href="https://publications.waset.org/abstracts/search?q=gastric%20ulcer" title=" gastric ulcer"> gastric ulcer</a>, <a href="https://publications.waset.org/abstracts/search?q=colon%20polyp" title=" colon polyp"> colon polyp</a> </p> <a href="https://publications.waset.org/abstracts/157000/a-case-of-mantle-cell-lymphoma-presenting-with-gi-symptoms-and-noted-to-have-extranodal-involvement-of-the-stomach-and-colon-on-presentation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/157000.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">157</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">154</span> The Clinical Significance of Cutaneous Leishmaniasis in Immigrant and Refugee Populations</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Promise%20Ufomadu">Promise Ufomadu</a>, <a href="https://publications.waset.org/abstracts/search?q=Edgar%20Rodriguez"> Edgar Rodriguez</a>, <a href="https://publications.waset.org/abstracts/search?q=Grace%20Lee"> Grace Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cutaneous Leishmaniasis (CL) is an infection caused by a variety of Leishmania species which are protozoan organisms that are typically carried by sandflies found in tropical regions. The parasite causes skin lesions that may resolve spontaneously but commonly become chronic and therefore necessitate thorough clinical attention. We present a 15-year-old female patient with CL of her bilateral dorsal hands, which resolved after a 28-day course of miltefosine. This case details the significance of compiling a thorough patient history and considering CL as a possible differential in patients from endemic regions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=leishmaniasis" title="leishmaniasis">leishmaniasis</a>, <a href="https://publications.waset.org/abstracts/search?q=infection" title=" infection"> infection</a>, <a href="https://publications.waset.org/abstracts/search?q=immigrant" title=" immigrant"> immigrant</a>, <a href="https://publications.waset.org/abstracts/search?q=parasites" title=" parasites"> parasites</a>, <a href="https://publications.waset.org/abstracts/search?q=pediatrics" title=" pediatrics"> pediatrics</a> </p> <a href="https://publications.waset.org/abstracts/168690/the-clinical-significance-of-cutaneous-leishmaniasis-in-immigrant-and-refugee-populations" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/168690.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">86</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">153</span> Physiological Normoxia and Cellular Adhesion of Diffuse Large B-Cell Lymphoma Primary Cells: Real-Time PCR and Immunohistochemistry Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kamila%20Du%C5%9B-Szachniewicz">Kamila Duś-Szachniewicz</a>, <a href="https://publications.waset.org/abstracts/search?q=Kinga%20M.%20Walaszek"> Kinga M. Walaszek</a>, <a href="https://publications.waset.org/abstracts/search?q=Pawe%C5%82%20Skiba"> Paweł Skiba</a>, <a href="https://publications.waset.org/abstracts/search?q=Pawe%C5%82%20Ko%C5%82odziej"> Paweł Kołodziej</a>, <a href="https://publications.waset.org/abstracts/search?q=Piotr%20Zi%C3%B3%C5%82kowski"> Piotr Ziółkowski</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cell adhesion is of fundamental importance in the cell communication, signaling, and motility, and its dysfunction occurs prevalently during cancer progression. The knowledge of the molecular and cellular processes involved in abnormalities in cancer cells adhesion has greatly increased, and it has been focused mainly on cellular adhesion molecules (CAMs) and tumor microenvironment. Unfortunately, most of the data regarding CAMs expression relates to study on cells maintained in standard oxygen condition of 21%, while the emerging evidence suggests that culturing cells in ambient air is far from physiological. In fact, oxygen in human tissues ranges from 1 to 11%. The aim of this study was to compare the effects of physiological lymph node normoxia (5% O2), and hyperoxia (21% O2) on the expression of cellular adhesion molecules of primary diffuse large B-cell lymphoma cells (DLBCL) isolated from 10 lymphoma patients. Quantitative RT-PCR and immunohistochemistry were used to confirm the differential expression of several CAMs, including ICAM, CD83, CD81, CD44, depending on the level of oxygen. Our findings also suggest that DLBCL cells maintained at ambient O2 (21%) exhibit reduced growth rate and migration ability compared to the cells growing in normoxia conditions. Taking into account all the observations, we emphasize the need to identify the optimal human cell culture conditions mimicking the physiological aspects of tumor growth and differentiation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adhesion%20molecules" title="adhesion molecules">adhesion molecules</a>, <a href="https://publications.waset.org/abstracts/search?q=diffuse%20large%20B-cell%20lymphoma" title=" diffuse large B-cell lymphoma"> diffuse large B-cell lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=physiological%20normoxia" title=" physiological normoxia"> physiological normoxia</a>, <a href="https://publications.waset.org/abstracts/search?q=quantitative%20RT-PCR" title=" quantitative RT-PCR"> quantitative RT-PCR</a> </p> <a href="https://publications.waset.org/abstracts/58050/physiological-normoxia-and-cellular-adhesion-of-diffuse-large-b-cell-lymphoma-primary-cells-real-time-pcr-and-immunohistochemistry-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/58050.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">278</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">152</span> Prognosis, Clinical Outcomes and Short Term Survival Analyses of Patients with Cutaneous Melanomas</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Osama%20Shakeel">Osama Shakeel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objective of the paper is to study the clinic-pathological factors, survival analyses, recurrence rate, metastatic rate, risk factors and the management of cutaneous malignant melanoma at Shaukat Khanum Memorial Cancer Hospital and Research Center. Methodology: From 2014 to 2017, all patients with a diagnosis of cutaneous malignant melanoma (CMM) were included in the study. Demographic variables were collected. Short and long term oncological outcomes were recorded. All data were entered and analyzed in SPSS version 21. Results: A total of 28 patients were included in the study. Median age was 46.5 +/-15.9 years. There were 16 male and 12 female patients. The family history of melanoma was present in 7.1% (n=2) of the patients. All patients had a mean survival of 13.43+/- 9.09 months. Lower limb was the commonest site among all which constitutes 46.4%(n=13). On histopathological analyses, ulceration was seen in 53.6% (n=15) patients. Unclassified tumor type was present in 75%(n=21) of the patients followed by nodular 21.4% (n=6) and superficial spreading 3.5%(n=1). Clark level IV was the commonest presentation constituting 46.4%(n=13). Metastases were seen in 50%(n=14) of the patients. Local recurrence was observed in 60.7%(n=17). 64.3%(n=18) lived after one year of treatment. Conclusion: CMM is a fatal disease. Although its disease of fair skin individuals, however, the incidence of CMM is also rising in this part of the world. Management includes early diagnoses and prompt management. However, mortality associated with this disease is still not favorable. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=malignant%20cancer%20of%20skin" title="malignant cancer of skin">malignant cancer of skin</a>, <a href="https://publications.waset.org/abstracts/search?q=cutaneous%20malignant%20melanoma" title=" cutaneous malignant melanoma"> cutaneous malignant melanoma</a>, <a href="https://publications.waset.org/abstracts/search?q=skin%20cancer" title=" skin cancer"> skin cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=survival%20analyses" title=" survival analyses"> survival analyses</a> </p> <a href="https://publications.waset.org/abstracts/101504/prognosis-clinical-outcomes-and-short-term-survival-analyses-of-patients-with-cutaneous-melanomas" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/101504.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">170</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">151</span> Congenital Sublingual Dermoid Cyst with Cutaneous Fistula</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rafael%20Ricieri">Rafael Ricieri</a>, <a href="https://publications.waset.org/abstracts/search?q=Rogerio%20Barros"> Rogerio Barros</a>, <a href="https://publications.waset.org/abstracts/search?q=Francisco%20Clovis"> Francisco Clovis</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective– The Objective of this is study is to report a rare case of dermoid cyst, with a sublingual location and cutaneous fistula in a 4 year-old child.Methods: This study is a case report. The main study instrument was the medical record and the radiological and intraoperative image bank. Results: Infants with congenital cervical lesions eventually need tomography for diagnostic elucidation, and health services should be structured to perform sedation and thin tomographic sections in order to reduce morbidity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=congenital" title="congenital">congenital</a>, <a href="https://publications.waset.org/abstracts/search?q=sublingual%20dermoid%20cyst" title=" sublingual dermoid cyst"> sublingual dermoid cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=fistula" title=" fistula"> fistula</a>, <a href="https://publications.waset.org/abstracts/search?q=pediatric%20surgery" title=" pediatric surgery"> pediatric surgery</a>, <a href="https://publications.waset.org/abstracts/search?q=head%20and%20kneck%20surgery" title=" head and kneck surgery"> head and kneck surgery</a> </p> <a href="https://publications.waset.org/abstracts/156843/congenital-sublingual-dermoid-cyst-with-cutaneous-fistula" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/156843.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">91</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">150</span> Pharmacogenetics Study of Dapsone-Induced Severe Cutaneous Adverse Reactions and HLA Class I Alleles in Thai Patients</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Patompong%20Satapornpong">Patompong Satapornpong</a>, <a href="https://publications.waset.org/abstracts/search?q=Therdpong%20Tempark"> Therdpong Tempark</a>, <a href="https://publications.waset.org/abstracts/search?q=Pawinee%20Rerknimitr"> Pawinee Rerknimitr</a>, <a href="https://publications.waset.org/abstracts/search?q=Jettanong%20Klaewsongkram"> Jettanong Klaewsongkram</a>, <a href="https://publications.waset.org/abstracts/search?q=Chonlaphat%20Sukasem"> Chonlaphat Sukasem</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Dapsone (4, 4’-diaminodiphenyl sulfone, DDS) is broadly used for the treatment of inflammatory diseases and infections such as; leprosy, Pneumocystis jiroveci pneumonia in patients with HIV infection, neutrophilic dermatoses, dermatitis herpetiformis and autoimmune bullous disease. The severe cutaneous adverse drug reactions (SCARs) including, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS) are rare but severe life-threatening adverse drug reactions. Dapsone is one of many culprit drugs induced SJS, TEN and DRESS. Notwithstanding, to our knowledge, there are no studies of the association of HLA class I alleles and dapsone-induced SCARs in non-leprosy Thai patients. This investigation was a prospective cohort study, which performed in a total of 45 non-leprosy patients. Fifteen patients of dapsone-induced SCARs were classified as following the RegiSCAR criteria, and 30 dapsone-tolerant controls were exposed to dapsone more than 6 months without any evidence of cutaneous reactions. The genotyping of HLA-A, -B and –C were performed using sequence-specific oligonucleotides (PCR-SSOs). The Ethics Committee of Ramathibodi hospital, Mahidol University, approved this study. Among all HLA class I alleles, HLA-A*24:07, HLA-B*13:01, HLA-B*15:02, HLA-C*03:04 and HLA-C*03:09 were significantly associated with dapsone-induced SCARs (OR = 10.55, 95% CI = 1.06 – 105.04, p = 0.0360; OR = 56.00, 95% CI = 8.27 – 379.22, p = 0.0001; OR = 7.00, 95% CI = 1.17 – 42.00, p = 0.0322; OR = 6.00, 95% CI = 1.24 – 29.07, p = 0.0425 and OR = 17.08, 95% CI = 0.82 – 355.45, p = 0.0321, respectively). Furthermore, HLA-B*13:01 allele had strong association with dapsone-induced SJS-TEN and DRESS when compared with dapsone-tolerant controls (OR = 42.00, 95% CI = 2.88 – 612.31, p = 0.0064 and OR = 63.00, 95% CI = 7.72 – 513.94 and p = 0.0001, respectively). Consequently, HLA-B*13:01 might serve as a pharmacogenetic marker for screening before initiating the therapy with dapsone for prevention of dapsone-induced SCARs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dapsone-induced%20SCARs" title="dapsone-induced SCARs">dapsone-induced SCARs</a>, <a href="https://publications.waset.org/abstracts/search?q=HLA-B%2A13%3A01" title=" HLA-B*13:01"> HLA-B*13:01</a>, <a href="https://publications.waset.org/abstracts/search?q=HLA%20class%20I%20alleles" title=" HLA class I alleles"> HLA class I alleles</a>, <a href="https://publications.waset.org/abstracts/search?q=severe%20cutaneous%20adverse%20reactions" title=" severe cutaneous adverse reactions"> severe cutaneous adverse reactions</a>, <a href="https://publications.waset.org/abstracts/search?q=Thai" title=" Thai"> Thai</a> </p> <a href="https://publications.waset.org/abstracts/74472/pharmacogenetics-study-of-dapsone-induced-severe-cutaneous-adverse-reactions-and-hla-class-i-alleles-in-thai-patients" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/74472.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">233</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">149</span> Prevalence of Cutaneous Leishmaniasis in Human Population of District Kurram, Khyber Pakhtunkhwa, Pakistan</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shah%20Abid">Shah Abid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Leishmaniasis is a collection of zoonotic infections that affect the viscera, skin, and mucous membrane and are spread by several species of female sandflies in the subfamily phlebotominae. The study's goal was to assess the prevalence of Cutaneous Leishmaniasis in District Kurram using descriptive and cross-sectional methods. From December 2022 to May 2023, the study was carried out at Tehsil Head Quarter (THQ) Hospital, Sadda, District Kurram in the Dermatology Department. The disease was identified using a laboratory method based on clinical manifestations of leishmaniasis. A clean slide's surface was applied to the scraped-off portion of the lesions and rubbed over the blood to make a smear on the slide. The slides were methanol-fixed, stained with traditional Giemsa, and meticulously examined at high magnification to search for LD bodies. The necessary information, such as residence area, lesion kind and location, age, sex, and the total number of lesions, was meticulously acquired. During the time of the investigation, 393 instances of cutaneous leishmaniasis were observed. 1 year to 70 years old was the age range (mean age: 35.45). The age group that was most severely impacted, 16 years and older, had 23 (11.67%) children with this condition. Male to female ratio was 9.7:10. Most of the cases (n=52, 26.29%), were reported in the month of May. Majority of the patients 102 (51.77%) had lesion on face. 42 (16.73) patients had multiple lesions on their body. Face was the most common site followed by lower limbs 93 (37.05). Weekly intralesional injections of sodium stibogluconate (glucantime) were administered to all patients. Without any noticeable adverse effects, all patients had positive responses to the treatment. The condition affects adults more commonly than children, according to analysis of the combined results, and it is more common in women than in men. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=District%20Kurram" title="District Kurram">District Kurram</a>, <a href="https://publications.waset.org/abstracts/search?q=cutaneous%20leishmaniasis" title=" cutaneous leishmaniasis"> cutaneous leishmaniasis</a>, <a href="https://publications.waset.org/abstracts/search?q=zoonosis" title=" zoonosis"> zoonosis</a>, <a href="https://publications.waset.org/abstracts/search?q=glucantime" title=" glucantime"> glucantime</a> </p> <a href="https://publications.waset.org/abstracts/193843/prevalence-of-cutaneous-leishmaniasis-in-human-population-of-district-kurram-khyber-pakhtunkhwa-pakistan" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/193843.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">9</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">148</span> Phenotype of Cutaneous Squamous Cell Carcinoma in a Brazilian City with a Tropical Climate</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Julia%20V.%20F.%20Cortes">Julia V. F. Cortes</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20E.%20V.%20Amarante"> Maria E. V. Amarante</a>, <a href="https://publications.waset.org/abstracts/search?q=Carolina%20L.%20Cerdeira"> Carolina L. Cerdeira</a>, <a href="https://publications.waset.org/abstracts/search?q=Roberta%20B.%20V.%20Silva"> Roberta B. V. Silva</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nonmelanoma skin cancer is more commonly diagnosed than all other malignancies combined. In that group, cutaneous squamous cell carcinoma stands out for having the highest probability of metastasis and recurrence after treatment, in addition to being the second most prevalent form of skin cancer. Its main risk factors include exposure to carcinogens, such as ultraviolet radiation related to sunlight exposure, smoking, alcohol consumption, and human papillomavirus (HPV) infection. Considering the increased risk of skin cancer in the Brazilian population, caused by the high incidence of solar radiation, and the importance of identifying risk phenotypes for the accomplishment of public health actions, an epidemiological study was conducted in a city with a tropical climate located in southeastern Brazil, aiming to identify the target population and assist in primary and secondary prevention. This study describes the profile of patients with cutaneous squamous cell cancer, correlating the variables, sex, age, and differentiation. The study used as primary data source the results of anatomopathological exams delivered from January 2015 to December 2019 for patients registered at one pathology service, which analyzes the results of biopsies, Thus, 66 patients with cutaneous squamous cell carcinoma were analyzed. The most affected age group was 60 years or older (78.79%), emphasizing that moderately differentiated (79.49%) and well-differentiated forms (66.67%) are prevalent in this age group, resulting in a difference of 12.82 percentage points between them. In addition, the predominant sex was male (58%), and it was found that half of the women and 65.79% of men had a moderately differentiated type, whereas the well-differentiated type was slightly more frequent in women. It is worth noting that the moderately differentiated subtype has a 59.20% prevalence among all cases. Thus, it was concluded that the most affected age group was 60 years or older and that men were more affected. As for the subtype, the moderately differentiated one, which is recognized for presenting the second-highest risk for metastasis, was prevalent in this study, affecting 6.6% more men and predominating in the elderly. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cutaneous%20squamous%20cell%20carcinoma" title="cutaneous squamous cell carcinoma">cutaneous squamous cell carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=epidemiology" title=" epidemiology"> epidemiology</a>, <a href="https://publications.waset.org/abstracts/search?q=skin%20cancer" title=" skin cancer"> skin cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=spinal%20cell%20cancer" title=" spinal cell cancer"> spinal cell cancer</a> </p> <a href="https://publications.waset.org/abstracts/132658/phenotype-of-cutaneous-squamous-cell-carcinoma-in-a-brazilian-city-with-a-tropical-climate" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/132658.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">117</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">147</span> Clinical Parameters Response to Low Level Laser Versus Monochromatic Near Infrared Photo Energy in Diabetic Patient with Peripheral Neuropathy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abeer%20Ahmed%20Abdehameed">Abeer Ahmed Abdehameed </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Diabetic sensorimotor polyneuropathy (DSP) is one of the most common micro vascular complications of type 2 diabetes. Loss of sensation is thought to contribute to lake of static and dynamic stability and increased risk of falling. Purpose: The purpose of this study was to compare the effects of low level laser (LLL) and monochromatic near infrared photo energy (MIRE) on pain , cutaneous sensation, static stability and index of lower limb blood flow in diabetic with peripheral neuropathy. Methods: Forty subjects with diabetic peripheral neuropathy were recruited for study. They were divided into two groups: The ( MIRE) group that included (20) patients and (LLL) group included (20) patients. All patients in the study had been subjected to various physical assessment procedures including pain, cutaneous sensation, Doppler flow meter and static stability assessments. The baseline measurements were followed by treatment sessions that conducted twice a week for 6 successive weeks. Results: The statistical analysis of the data had revealed significant improvement of the pain in both groups, with significant improvement in cutaneous sensation and static balance in (MIRE) group compared to (LLL) group; on the other hand results showed no significant differences on lower limb blood flow in both groups. Conclusion: Low level laser and monochromatic near infrared therapy can improve painful symptoms in patients with diabetic neuropathy. On the other hand (MIRE) is useful in improving cutaneous sensation and static stability in patients with diabetic neuropathy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetic%20neuropathy" title="diabetic neuropathy">diabetic neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=doppler%20flow%20meter" title=" doppler flow meter"> doppler flow meter</a>, <a href="https://publications.waset.org/abstracts/search?q=low%20level%20laser" title=" low level laser"> low level laser</a>, <a href="https://publications.waset.org/abstracts/search?q=monochromatic%20near%20infrared%20photo%20energy" title=" monochromatic near infrared photo energy"> monochromatic near infrared photo energy</a> </p> <a href="https://publications.waset.org/abstracts/31260/clinical-parameters-response-to-low-level-laser-versus-monochromatic-near-infrared-photo-energy-in-diabetic-patient-with-peripheral-neuropathy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31260.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">314</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">146</span> Automatic Differential Diagnosis of Melanocytic Skin Tumours Using Ultrasound and Spectrophotometric Data</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kristina%20Sakalauskiene">Kristina Sakalauskiene</a>, <a href="https://publications.waset.org/abstracts/search?q=Renaldas%20Raisutis"> Renaldas Raisutis</a>, <a href="https://publications.waset.org/abstracts/search?q=Gintare%20Linkeviciute"> Gintare Linkeviciute</a>, <a href="https://publications.waset.org/abstracts/search?q=Skaidra%20Valiukeviciene"> Skaidra Valiukeviciene</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cutaneous melanoma is a melanocytic skin tumour, which has a very poor prognosis while is highly resistant to treatment and tends to metastasize. Thickness of melanoma is one of the most important biomarker for stage of disease, prognosis and surgery planning. In this study, we hypothesized that the automatic analysis of spectrophotometric images and high-frequency ultrasonic 2D data can improve differential diagnosis of cutaneous melanoma and provide additional information about tumour penetration depth. This paper presents the novel complex automatic system for non-invasive melanocytic skin tumour differential diagnosis and penetration depth evaluation. The system is composed of region of interest segmentation in spectrophotometric images and high-frequency ultrasound data, quantitative parameter evaluation, informative feature extraction and classification with linear regression classifier. The segmentation of melanocytic skin tumour region in ultrasound image is based on parametric integrated backscattering coefficient calculation. The segmentation of optical image is based on Otsu thresholding. In total 29 quantitative tissue characterization parameters were evaluated by using ultrasound data (11 acoustical, 4 shape and 15 textural parameters) and 55 quantitative features of dermatoscopic and spectrophotometric images (using total melanin, dermal melanin, blood and collagen SIAgraphs acquired using spectrophotometric imaging device SIAscope). In total 102 melanocytic skin lesions (including 43 cutaneous melanomas) were examined by using SIAscope and ultrasound system with 22 MHz center frequency single element transducer. The diagnosis and Breslow thickness (pT) of each MST were evaluated during routine histological examination after excision and used as a reference. The results of this study have shown that automatic analysis of spectrophotometric and high frequency ultrasound data can improve non-invasive classification accuracy of early-stage cutaneous melanoma and provide supplementary information about tumour penetration depth. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cutaneous%20melanoma" title="cutaneous melanoma">cutaneous melanoma</a>, <a href="https://publications.waset.org/abstracts/search?q=differential%20diagnosis" title=" differential diagnosis"> differential diagnosis</a>, <a href="https://publications.waset.org/abstracts/search?q=high-frequency%20ultrasound" title=" high-frequency ultrasound"> high-frequency ultrasound</a>, <a href="https://publications.waset.org/abstracts/search?q=melanocytic%20skin%20tumours" title=" melanocytic skin tumours"> melanocytic skin tumours</a>, <a href="https://publications.waset.org/abstracts/search?q=spectrophotometric%20imaging" title=" spectrophotometric imaging"> spectrophotometric imaging</a> </p> <a href="https://publications.waset.org/abstracts/94893/automatic-differential-diagnosis-of-melanocytic-skin-tumours-using-ultrasound-and-spectrophotometric-data" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/94893.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">270</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">145</span> Isolation, Identification and Measurement of Cottonseed Oil Gossypol in the Treatment of Drug-Resistant Cutaneous Leishmaniasis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sara%20Taghdisi">Sara Taghdisi</a>, <a href="https://publications.waset.org/abstracts/search?q=Mehrosadat%20Mirmohammadi"> Mehrosadat Mirmohammadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Mostafa%20Mokhtarian"> Mostafa Mokhtarian</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Hossein%20Pazandeh"> Mohammad Hossein Pazandeh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Leishmaniasis is one of the 10 most important diseases of the World Health Organization with health problems in more than 90 countries. Over one billion people are at risk of these diseases on almost every continent. The present human study was performed to evaluate the therapeutic effect of cotton plant on cutaneous leishmaniasis leision. firstly, the cotton seeds were cleaned and grinded to smaller particles. In the second step, the seeds were oiled by cold press method. In order to separate bioactive compound, after saponification of the oil, its gossypol was hydrolyzed and crystalized. finally, the therapeutic effect of Cottonseed Oil on cutaneous leishmaniasis was investigated. In the current project, Gossypol was extracted with a liquid-liquid extraction method in 120 minutes in the presence of Phosphoric acid from the cotton seed oil of Golestan beach varieties, then got crystallized in darkness using Acetic acid and isolated as Gossypol Acetic acid. The efficiency of the extracted crystal was obtained at 1.28±0.12. the cotton plant could be efficient in the treatment of Cutaneous leishmaniasis. This double-blind randomized controlled clinical trial was performed on 88 cases of leishmaniasis wounds. Patients were randomly divided into two groups of 44 cases. two groups received conventional treatment. In addition to the usual treatment (glucantime), the first group received cottonseed oil and the control group received placebo. The results of the present study showed that the surface of lesion before the intervention and in the first to fourth weeks after the intervention was not significantly different between the two groups (P-value> 0.05). But the surface of lesion in the Intervention group in the eighth and twelfth weeks was lower than the control group (P-value <0.05). This study showed that the improvement of leishmaniasis lesion using topical cotton plant mark in the eighth and twelfth weeks after the intervention was significantly more than the control group. Considering the most common chemical drugs for Cutaneous leishmaniasis treatment are sodium stibogluconate, and meglumine antimonate, which not only have relatively many side effects, but also some species of the Leishmania genus have become resistant to them. Therefore, a plant base bioactive compound such as cottonseed oil can be useful whit fewer side effects. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cottonseed%20oil" title="cottonseed oil">cottonseed oil</a>, <a href="https://publications.waset.org/abstracts/search?q=crystallization" title=" crystallization"> crystallization</a>, <a href="https://publications.waset.org/abstracts/search?q=gossypol" title=" gossypol"> gossypol</a>, <a href="https://publications.waset.org/abstracts/search?q=leishmaniasis" title=" leishmaniasis"> leishmaniasis</a> </p> <a href="https://publications.waset.org/abstracts/184861/isolation-identification-and-measurement-of-cottonseed-oil-gossypol-in-the-treatment-of-drug-resistant-cutaneous-leishmaniasis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/184861.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">60</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">144</span> Finding Bicluster on Gene Expression Data of Lymphoma Based on Singular Value Decomposition and Hierarchical Clustering</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alhadi%20Bustaman">Alhadi Bustaman</a>, <a href="https://publications.waset.org/abstracts/search?q=Soeganda%20Formalidin"> Soeganda Formalidin</a>, <a href="https://publications.waset.org/abstracts/search?q=Titin%20Siswantining"> Titin Siswantining</a> </p> <p class="card-text"><strong>Abstract:</strong></p> DNA microarray technology is used to analyze thousand gene expression data simultaneously and a very important task for drug development and test, function annotation, and cancer diagnosis. Various clustering methods have been used for analyzing gene expression data. However, when analyzing very large and heterogeneous collections of gene expression data, conventional clustering methods often cannot produce a satisfactory solution. Biclustering algorithm has been used as an alternative approach to identifying structures from gene expression data. In this paper, we introduce a transform technique based on singular value decomposition to identify normalized matrix of gene expression data followed by Mixed-Clustering algorithm and the Lift algorithm, inspired in the node-deletion and node-addition phases proposed by Cheng and Church based on Agglomerative Hierarchical Clustering (AHC). Experimental study on standard datasets demonstrated the effectiveness of the algorithm in gene expression data. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=agglomerative%20hierarchical%20clustering%20%28AHC%29" title="agglomerative hierarchical clustering (AHC)">agglomerative hierarchical clustering (AHC)</a>, <a href="https://publications.waset.org/abstracts/search?q=biclustering" title=" biclustering"> biclustering</a>, <a href="https://publications.waset.org/abstracts/search?q=gene%20expression%20data" title=" gene expression data"> gene expression data</a>, <a href="https://publications.waset.org/abstracts/search?q=lymphoma" title=" lymphoma"> lymphoma</a>, <a href="https://publications.waset.org/abstracts/search?q=singular%20value%20decomposition%20%28SVD%29" title=" singular value decomposition (SVD)"> singular value decomposition (SVD)</a> </p> <a href="https://publications.waset.org/abstracts/72889/finding-bicluster-on-gene-expression-data-of-lymphoma-based-on-singular-value-decomposition-and-hierarchical-clustering" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/72889.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">278</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">143</span> Cutaneous Sarcoidosis Treated with Narrow Band Ultraviolet B (NBUVB) Phototherapy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hannah%20Riva">Hannah Riva</a>, <a href="https://publications.waset.org/abstracts/search?q=Sarah%20Mazal"> Sarah Mazal</a>, <a href="https://publications.waset.org/abstracts/search?q=Jessica%20L.%20Marquez"> Jessica L. Marquez</a>, <a href="https://publications.waset.org/abstracts/search?q=Michael%20Rains"> Michael Rains</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A 70-year-old female with a Fitzpatrick skin phenotype II presented with a 13-year history of a scaly rash located on the left breast and bilateral pretibial regions. The patient’s past medical history was otherwise unremarkable, with the exception of surgery involving the left breast. Physical examination revealed infiltrative hyperpigmented scaly plaques and nodules located on the left breast and pretibial regions bilaterally. A negative systemic workup excluded organ involvement. A clinical diagnosis of cutaneous sarcoidosis was made. Prior treatments included triamcinolone 0.1% topical cream and clobetasol 0.05% ointment, which failed to show improvement. Full-body narrow-band UVB (NBUVB) treatment was performed on a tri-weekly basis for eight months. NBUVB dosage was slowly titrated from 300 mJ/cm2 to a final dose of 1800 mJ/cm2 to prevent discomfort and burning sensations. Throughout the duration of her treatment, the patient adhered to a regimen of clobetasol 0.05% topical ointment applied twice daily in two-week intervals. Improvement was noticed after two months, with continued improvement up to eight months. The patient is continuing NBUVB phototherapy treatments for maintenance. In our case, NBUVB phototherapy treatment demonstrated promising results with improvement after two months of treatment. Physicians should consider NBUVB phototherapy as an effective option for patients presenting with cutaneous sarcoidosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dermatology" title="dermatology">dermatology</a>, <a href="https://publications.waset.org/abstracts/search?q=sarcoidosis" title=" sarcoidosis"> sarcoidosis</a>, <a href="https://publications.waset.org/abstracts/search?q=phototherapy" title=" phototherapy"> phototherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=ultraviolet" title=" ultraviolet"> ultraviolet</a> </p> <a href="https://publications.waset.org/abstracts/168345/cutaneous-sarcoidosis-treated-with-narrow-band-ultraviolet-b-nbuvb-phototherapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/168345.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">72</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=cutaneous%20lymphoma&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=cutaneous%20lymphoma&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=cutaneous%20lymphoma&page=4">4</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=cutaneous%20lymphoma&page=5">5</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=cutaneous%20lymphoma&page=6">6</a></li> <li class="page-item"><a class="page-link" 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