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Research within the journal covers a broad spectrum, including HCC diagnosis, treatment, prognosis, and detection markers. This encompasses liver cancer animal models, liver transplantation, molecular targeted therapy for liver cancer, immunotherapy for liver cancer, interventional therapy for liver cancer, and various multidimensional treatment options."><meta data-n-head="ssr" name="keywords" content=""><meta data-n-head="ssr" name="twitter:title" content="Hepatoma Research - OAE Publishing Inc."><meta data-n-head="ssr" name="twitter:type" content="OAE Publishing Inc."><meta data-n-head="ssr" name="twitter:description" content="Hepatoma Research, a peer-reviewed journal led by Editor-in-Chief Guang-Wen Cao, focuses on the field of hepatocellular carcinoma (HCC), delving into the role of HBV in the development of liver cancer. The journal explores carcinogenic mechanisms and the development of biomarkers for liver and biliary tract cancers. Research within the journal covers a broad spectrum, including HCC diagnosis, treatment, prognosis, and detection markers. This encompasses liver cancer animal models, liver transplantation, molecular targeted therapy for liver cancer, immunotherapy for liver cancer, interventional therapy for liver cancer, and various multidimensional treatment options."><meta data-n-head="ssr" property="og:url" content="/hr"><meta data-n-head="ssr" property="og:type" content="OAE Publishing Inc."><meta data-n-head="ssr" property="og:site_name" content="Hepatoma Research"><meta data-n-head="ssr" property="og:title" content="Hepatoma Research"><title>Hepatoma Research - OAE Publishing Inc.</title><link data-n-head="ssr" rel="icon" type="image/x-icon" href="/favicon.ico"><link data-n-head="ssr" rel="canonical" href="https://www.oaepublish.com/hr"><script data-n-head="ssr" src="https://accounts.google.com/gsi/client" async></script><script data-n-head="ssr" src="https://g.oaes.cc/oae/dist/relijs.js" async></script><link rel="preload" href="https://g.oaes.cc/oae/nuxt/47b9fdf.js" as="script"><link rel="preload" 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<div data-server-rendered="true" id="__nuxt"><div id="__layout"><div data-fetch-key="qklayoutc:0"><div><div class="PcComment" data-v-1c35eca8><div class="ipad_bg" style="display:none;" data-v-1c35eca8></div> <div class="head_top" data-v-1c35eca8><div class="wrapper head_box" data-v-1c35eca8><span class="qk_jx" data-v-1c35eca8><img src="https://i.oaes.cc/upload/journal_logo/hr.jpg" alt data-v-1c35eca8></span> <a href="/hr" aria-current="page" class="qk_a_name nuxt-link-exact-active nuxt-link-active" data-v-1c35eca8><span class="title font20" data-v-1c35eca8>Hepatoma Research</span></a> <div class="top_img" data-v-1c35eca8><a href="https://www.scopus.com/sourceid/21101058282" target="_blank" data-v-1c35eca8><img src="https://i.oaes.cc/uploads/20240313/ee358186a06449d5b2c8ea15f712cbed.png" alt data-v-1c35eca8></a><a href="https://jcr.clarivate.com/jcr-jp/journal-profile?journal=HEPATOMA%20RES&year=2023" target="_blank" data-v-1c35eca8><img 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data-v-1c35eca8><div class="box_btn" data-v-1c35eca8><div class="qk_miss" data-v-1c35eca8><img src="https://i.oaes.cc/uploads/20250113/dd32d8db871b408e807c357d389911e4.jpg" alt class="qk_fm" data-v-1c35eca8> <div class="miss_right" data-v-1c35eca8><div class="miss_btn" data-v-1c35eca8><span data-v-1c35eca8><span class="font_b" data-v-1c35eca8>Editor-in-Chief:</span> Guang-Wen Cao</span></div> <div class="miss_btn" data-v-1c35eca8><div class="text_index" data-v-1c35eca8><span class="font_b" data-v-1c35eca8>Indexing: </span> <span data-v-1c35eca8><a href="https://mjl.clarivate.com/search-results" target="_blank" data-v-1c35eca8>ESCI</a><span class="xing_d" data-v-1c35eca8>, </span></span><span data-v-1c35eca8><a href="https://cassi.cas.org/publication.jsp?P=eCQtRPJo9AQyz133K_ll3zLPXfcr-WXfQs7p4ZyIFgwwaz4Oot-4TW6C1B6eacgNMs9d9yv5Zd_EQxVEcOT7t9T2F4sGrwmHMs9d9yv5Zd9DQZYXcwMqT5_7Gw0kvFTJ" target="_blank" data-v-1c35eca8>CAS</a><span class="xing_d" data-v-1c35eca8>, </span></span><span data-v-1c35eca8><a href="https://www.scopus.com/sourceid/21101058282" target="_blank" data-v-1c35eca8>Scopus</a><span class="xing_d" data-v-1c35eca8>, </span></span><span data-v-1c35eca8><a href="https://www.wanfangdata.com.cn/index.html?index=true" target="_blank" data-v-1c35eca8>Wanfang Data</a><span class="xing_d" data-v-1c35eca8>, </span></span><span data-v-1c35eca8><a href="https://scholar.cnki.net/journal/index/SJWK245425200230" target="_blank" data-v-1c35eca8>CNKI</a><span class="xing_d" data-v-1c35eca8>, </span></span><span data-v-1c35eca8><a href="https://app.dimensions.ai/discover/publication?and_facet_source_title=jour.1150867" target="_blank" data-v-1c35eca8>Dimensions</a><span class="xing_d" data-v-1c35eca8>, </span></span><span data-v-1c35eca8><a href="https://beta.elsevier.com/products/embase/content?trial=true" target="_blank" data-v-1c35eca8>Embase</a><span class="xing_d" data-v-1c35eca8>, </span></span></div> <div class="text_jour" data-v-1c35eca8><span class="font_b" data-v-1c35eca8>Journal Rank: </span><span data-v-1c35eca8>CiteScore 3.2 - Impact Factor 1.7, Q3 (Gastroenterology & Hepatology)</span><span data-v-1c35eca8> </span><span class="font_b" data-v-1c35eca8>Submission to first decision: </span><span data-v-1c35eca8>74 days</span></div></div> <div class="btn_box_t" data-v-1c35eca8><button type="button" class="el-button el-button--text " data-v-1c35eca8><span><a href="https://i.oaes.cc/uploads/20230129/52be631e29b24fe7b1832a6e2ccbb58d.pdf" target="_blank" data-v-1c35eca8><i class="icon-download font20" data-v-1c35eca8></i> Journal Flyer</a></span></button></div></div></div> <div class="grid-content bg-purple search_box" data-v-1c35eca8><span data-v-1c35eca8><div role="tooltip" id="el-popover-5267" aria-hidden="true" class="el-popover el-popper" style="width:undefinedpx;display:none;">  <div class="search_hot" data-v-1c35eca8><div class="title" data-v-1c35eca8><span class="text" data-v-1c35eca8>Hot Keywords</span></div> <div class="hot_list" data-v-1c35eca8><span data-v-1c35eca8>Hepatocellular carcinoma</span><span data-v-1c35eca8> HCC</span><span data-v-1c35eca8> Liver Cancer</span><span data-v-1c35eca8> Liver tumors</span><span data-v-1c35eca8> Hepatoblastoma</span><span data-v-1c35eca8> Cholangiocarcinoma</span><span data-v-1c35eca8> Nonalcoholic fatty liver disease</span><span data-v-1c35eca8> Nonalcoholic steatohepatitis</span><span data-v-1c35eca8> Hepatitis B; Hepatitis C</span><span data-v-1c35eca8> Immunotherapy</span><span data-v-1c35eca8> Systemic treatment</span><span data-v-1c35eca8> Liver transplantation</span><span data-v-1c35eca8> Liver resection</span><span data-v-1c35eca8> Surgical</span><span data-v-1c35eca8> Management</span><span data-v-1c35eca8> Surveillance</span><span data-v-1c35eca8> Epidemiology</span><span data-v-1c35eca8> Molecular mechanisms</span><span data-v-1c35eca8> Tumor microenvironment</span><span data-v-1c35eca8> Biomarker</span><span data-v-1c35eca8> Stem 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class="qk_jx" data-v-3e280d43><img src="https://i.oaes.cc/upload/journal_logo/hr.jpg" alt="" data-v-3e280d43></span></a> <div class="head_left" data-v-3e280d43><a href="/" class="tab_item nuxt-link-active" data-v-3e280d43><span class="title font18" data-v-3e280d43>Hepatoma Research</span></a></div> <div class="head_right" data-v-3e280d43><a href="/hr/search" class="search" data-v-3e280d43><span data-v-3e280d43>Search</span></a> <span class="go_oae" style="background:rgb(239,108,62);" data-v-3e280d43><a href="https://www.oaecenter.com/login?JournalId=hr" target="_blank" data-v-3e280d43><span data-v-3e280d43>Submit</span></a></span></div></div> <div class="cg" style="height: 50px" data-v-3e280d43></div> <div class="fix_box" data-v-3e280d43><div class="miss_right" data-v-3e280d43><div class="flex_tit" data-v-3e280d43><div class="top_img" data-v-3e280d43><a href="https://www.scopus.com/sourceid/21101058282" target="_blank" data-v-3e280d43><img src="https://i.oaes.cc/uploads/20240313/ee358186a06449d5b2c8ea15f712cbed.png" alt data-v-3e280d43></a><a href="https://jcr.clarivate.com/jcr-jp/journal-profile?journal=HEPATOMA%20RES&year=2023" target="_blank" data-v-3e280d43><img src="https://i.oaes.cc/uploads/20240625/af5ee9028a554c6aa6f0030bbcbfe55d.png" alt data-v-3e280d43></a><a href="https://mjl.clarivate.com/search-results" target="_blank" data-v-3e280d43><img src="https://i.oaes.cc/uploads/20240506/ea3d9071c35b4bf3982ffe25f1083620.png" alt data-v-3e280d43></a></div></div> <div class="miss_btn wid70" data-v-3e280d43><div data-v-3e280d43><div data-v-3e280d43><span class="font_b" data-v-3e280d43>Editor-in-Chief:</span> Guang-Wen Cao</div></div></div> <div class="miss_btn" style="width:calc(100% - 111px);" data-v-3e280d43></div> <div data-v-3e280d43><div data-v-3e280d43><span class="font_b" data-v-3e280d43>Journal Rank: </span><span data-v-3e280d43>CiteScore 3.2 - Impact Factor 1.7, Q3 (Gastroenterology & Hepatology)</span></div> <div data-v-3e280d43><span class="font_b" data-v-3e280d43>Submission to first decision: </span>74 days</div></div></div> <div class="hot_search" style="display:none;" data-v-3e280d43 data-v-3e280d43> <div class="search_hot" data-v-3e280d43><div class="title" data-v-3e280d43><span class="text" data-v-3e280d43>Hot Keywords</span></div> <div class="hot_list" data-v-3e280d43><span data-v-3e280d43>Hepatocellular carcinoma</span><span data-v-3e280d43> HCC</span><span data-v-3e280d43> Liver Cancer</span><span data-v-3e280d43> Liver tumors</span><span data-v-3e280d43> Hepatoblastoma</span><span data-v-3e280d43> Cholangiocarcinoma</span><span data-v-3e280d43> Nonalcoholic fatty liver disease</span><span data-v-3e280d43> Nonalcoholic steatohepatitis</span><span data-v-3e280d43> Hepatitis B; Hepatitis C</span><span data-v-3e280d43> Immunotherapy</span><span data-v-3e280d43> Systemic treatment</span><span data-v-3e280d43> Liver transplantation</span><span data-v-3e280d43> Liver resection</span><span data-v-3e280d43> Surgical</span><span data-v-3e280d43> Management</span><span data-v-3e280d43> Surveillance</span><span data-v-3e280d43> Epidemiology</span><span data-v-3e280d43> Molecular mechanisms</span><span data-v-3e280d43> Tumor microenvironment</span><span data-v-3e280d43> Biomarker</span><span data-v-3e280d43> Stem cell</span></div></div></div> <div class="navigation colorH_hr" style="border-bottom:2px solid rgb(239,108,62);" data-v-3e280d43><div class="nav_box" data-v-3e280d43><div class="nav_list" data-v-3e280d43><a href="/hr" aria-current="page" class="tab_item nuxt-link-exact-active nuxt-link-active" data-v-3e280d43><span class="tab_span" data-v-3e280d43>Home</span></a> <a href="/hr/articles" class="tab_item" data-v-3e280d43><span class="tab_span" data-v-3e280d43>Articles</span></a> <a href="/hr/special_issues" class="tab_item" data-v-3e280d43><span class="tab_span" data-v-3e280d43>Special Issues</span></a> <a href="/hr/volumes" class="tab_item" 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data-v-9d35a14e><span role="link" class="el-breadcrumb__inner">hr</span><span role="presentation" class="el-breadcrumb__separator"></span></span></div> <div class="el-row" style="margin-left:-10px;margin-right:-10px;" data-v-9d35a14e><div class="el-col el-col-24 el-col-xs-24 el-col-sm-16 el-col-md-18" style="padding-left:10px;padding-right:10px;" data-v-9d35a14e><div data-v-c1f41ab4 data-v-9d35a14e><div class="banner_box" data-v-c1f41ab4><div class="grid-content banner_cont pad_r_10" data-v-c1f41ab4><div class="banner_box_b" data-v-c1f41ab4> <div class="swiper-container" data-v-5c8e3c6d data-v-c1f41ab4><div class="swiper-wrapper" data-v-5c8e3c6d><div class="swiper-slide" data-v-5c8e3c6d><a href="https://www.oaepublish.com/news/hr.861" data-v-5c8e3c6d><div class="tit" data-v-5c8e3c6d><div class="title" data-v-5c8e3c6d><a href="https://www.oaepublish.com/news/hr.861" data-v-5c8e3c6d><span data-v-5c8e3c6d>Congratulations! 50 Editorial Board Members of <i>Hepatoma Research</i> Named Among the Top 2% of Global Scientists in 2024!</span></a></div> <div class="title_sm" data-v-5c8e3c6d><span data-v-5c8e3c6d>This prestigious ranking identifies the top 2% of scientists globally from over 7 million scientists, spanning 22 fields and 174 sub-disciplines.</span></div></div> <img src="https://i.oaes.cc/uploads/20241015/fc8986719d484c80aaf3a786459bc49c.jpg" alt data-v-5c8e3c6d></a></div><div class="swiper-slide" data-v-5c8e3c6d><a href="https://www.oaepublish.com/news/hr.813" data-v-5c8e3c6d><div class="tit" data-v-5c8e3c6d><div class="title" data-v-5c8e3c6d><a href="https://www.oaepublish.com/news/hr.813" data-v-5c8e3c6d><span data-v-5c8e3c6d><i>Hepatoma Research</i> Received the First Impact Factor！</span></a></div> <div class="title_sm" data-v-5c8e3c6d><span data-v-5c8e3c6d><i>Hepatoma Research</i> received its first impact factor of 1.7! It is ranked in the Q3 quartile within the field of Gastroenterology & Hepatology.</span></div></div> <img src="https://i.oaes.cc/uploads/20240620/0816fad2e1944a3c8f5f3556d078c783.jpg" alt data-v-5c8e3c6d></a></div><div class="swiper-slide" data-v-5c8e3c6d><a href="https://www.oaepublish.com/news/hr.797" data-v-5c8e3c6d><div class="tit" data-v-5c8e3c6d><div class="title" data-v-5c8e3c6d><a href="https://www.oaepublish.com/news/hr.797" data-v-5c8e3c6d><span data-v-5c8e3c6d><i>Hepatoma Research</i> Achieves Significant Increase with a 2023 CiteScore of 3.2! </span></a></div> <div class="title_sm" data-v-5c8e3c6d><span data-v-5c8e3c6d><i>Hepatoma Research</i> achieved a remarkable CiteScore of 3.2 for 2023, a significant improvement from 2.5 in 2022.</span></div></div> <img src="https://i.oaes.cc/uploads/20240620/9b3e00992cc949e18a17a9627fa2785a.jpg" alt data-v-5c8e3c6d></a></div><div class="swiper-slide" data-v-5c8e3c6d><a href="https://www.oaepublish.com/news/hr.787" data-v-5c8e3c6d><div class="tit" data-v-5c8e3c6d><div class="title" data-v-5c8e3c6d><a href="https://www.oaepublish.com/news/hr.787" data-v-5c8e3c6d><span data-v-5c8e3c6d>Welcome Six New Associate Chief Editors of <i> Hepatoma Research</i> </span></a></div> <div class="title_sm" data-v-5c8e3c6d><span data-v-5c8e3c6d><i>Hepatoma Research</i> is delighted to announce the appointment of six world-renowned scientists to serve as Associate Chief Editors.</span></div></div> <img src="https://i.oaes.cc/uploads/20240527/9b27c791dcc64d459bda34eb02194b07.jpg" alt data-v-5c8e3c6d></a></div><div class="swiper-slide" data-v-5c8e3c6d><a href="https://www.oaepublish.com/news/hr.751" data-v-5c8e3c6d><div class="tit" data-v-5c8e3c6d><div class="title" data-v-5c8e3c6d><a href="https://www.oaepublish.com/news/hr.751" data-v-5c8e3c6d><span data-v-5c8e3c6d><i>Hepatoma Research|</i> 2024 Best Paper Awards</span></a></div> <div class="title_sm" data-v-5c8e3c6d><span data-v-5c8e3c6d>The Selection Committee of <i>Hepatoma Research</i> has identified five papers as exemplary contributions</span></div></div> <img src="https://i.oaes.cc/uploads/20240415/b5143760500549538d8f9dea82c4fb7c.jpg" alt data-v-5c8e3c6d></a></div></div> <div class="swiper-pagination" style="display:;" data-v-5c8e3c6d></div> <div class="swiper-button-prev" style="display:;" data-v-5c8e3c6d><img src="https://g.oaes.cc/oae/nuxt/img/slide-left30x40_@3x.5042b29.png" alt class="btn_swiper" data-v-5c8e3c6d></div> <div class="swiper-button-next" style="display:;" data-v-5c8e3c6d><img src="https://g.oaes.cc/oae/nuxt/img/slide-right30x40_@3x.21cefa8.png" alt class="btn_swiper" data-v-5c8e3c6d></div></div></div></div></div></div> <div class="grid-content index_left pad_r_10" data-v-9d35a14e> <div class="hot_art" data-v-9d35a14e><div data-v-ab8748fc data-v-9d35a14e><div class="PcTitle" data-v-ab8748fc><div class="top_line" data-v-ab8748fc></div> <div class="tit_box" data-v-ab8748fc><a href="/hr/featured" class="title_h" data-v-ab8748fc>Featured Articles<i class="el-icon-arrow-right" data-v-ab8748fc></i></a></div> <div class="line_btn" style="margin-top: 10px;" data-v-ab8748fc></div></div></div> <div class="art_item" data-v-9d35a14e><a href="/articles/2394-5079.2021.131" data-v-9d35a14e><h4 class="article-header bor_btn" data-v-9d35a14e>Hepatocellular carcinoma surveillance: current practice and future directions</h4></a></div><div class="art_item" data-v-9d35a14e><a href="/articles/2394-5079.2021.106" data-v-9d35a14e><h4 class="article-header bor_btn" data-v-9d35a14e>Histopathology of hepatocellular carcinoma - when and what</h4></a></div><div class="art_item" data-v-9d35a14e><a href="/articles/2394-5079.2021.123" data-v-9d35a14e><h4 class="article-header bor_btn" data-v-9d35a14e>Understanding immune perspectives and options for the use of checkpoint immunotherapy in HCC post liver transplant</h4></a></div><div class="art_item" data-v-9d35a14e><a href="/articles/2394-5079.2021.122" data-v-9d35a14e><h4 class="article-header bor_btn" data-v-9d35a14e>Advances in Y-90 radioembolization for the treatment of hepatocellular carcinoma</h4></a></div><div class="art_item" data-v-9d35a14e><a href="/articles/2394-5079.2022.75" data-v-9d35a14e><h4 class="article-header bor_btn" data-v-9d35a14e>Liver Transplantation for perihilar cholangiocarcinoma. 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Do we need to move forward?",id:P}],video:{id:387,title:"Special Interview with Prof. Lewis R. Roberts from Mayo Clinic",video_url:"https:\u002F\u002Fv.oaes.cc\u002Fuploads\u002F20240724\u002F4401c874e56a44fd9da9cc900c5e7b14.mp4",img_url:"https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20240724\u002Fe5553038056d4c9f8188b3d3658bce16.png",link:"https:\u002F\u002Fwww.oaepublish.com\u002Finterviews\u002Fhr.233",journal_id:m,type:"academic",videos_home_url:"\u002Facademic_talks"}},indexMid:{articles:{recent:[{article_id:"7696",title:"Application of multi-omics in hepatocellular carcinoma: new prospects for classification and precise diagnosis and treatment",image:Q,tag:k,doi:"10.20517\u002F2394-5079.2024.124",date_published:"1737561600",section:j,authors:"Jiaxue He, ... Yanfang Jiang\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-2478-1521' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Yanfang Jiang'\u003E\u003C\u002Fa\u003E",journal_id:f,volume:n,year:s,section_id:"2030",special_name:R,url_doi:"2394-5079.2024.124",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F92b4eee0-1e12-4592-b8a0-8b477e8cf88d\u002Fhr100124.pdf",video_url:a,allauthors:"\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Jiaxue He'\u003E Jiaxue He, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Xintong Hu'\u003E Xintong Hu, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Liguo Chen'\u003E Liguo Chen, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Yanfang Jiang'\u003E Yanfang Jiang\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-2478-1521' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Yanfang Jiang'\u003E\u003C\u002Fa\u003E",journal_path:b,video_img:a,image_list:Q,abstract:"\u003Cp\u003EHepatocellular carcinoma (HCC) represents a significant global health challenge, with a complex etiology and limited treatment options. The integration of multi-omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, has revolutionized our understanding of HCC, offering novel insights into its molecular underpinnings. This comprehensive review synthesizes the current knowledge on the application of multi-omics in HCC, highlighting its role in disease classification, early detection, and the development of targeted therapies. We discuss the identification of key driver mutations and single nucleotide polymorphisms (SNPs) that enhance risk prediction models, with implications for personalized medicine. The multi-omics approach has facilitated the discovery of distinct HCC subtypes, each with unique molecular signatures and tumor microenvironments (TME), which are critical for predicting prognosis and guiding treatment strategies. Furthermore, we explore the implications of these findings for precision medicine, emphasizing the potential of biomarker identification and targeted therapies, including immune checkpoint blockade (ICB). The review concludes by underscoring the transformative impact of multi-omics on HCC research and clinical practice, heralding a new era of personalized medicine with the promise of improved patient outcomes.\u003C\u002Fp\u003E"},{article_id:"7672",title:"Epidemiological characteristics and precise prophylaxis and control of HBV-associated primary liver cancer",image:S,tag:i,doi:"10.20517\u002F2394-5079.2024.132",date_published:"1737129600",section:j,authors:"Yuqi Feng, ... Guangwen Cao\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-8094-1278' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Guangwen Cao'\u003E\u003C\u002Fa\u003E",journal_id:f,volume:n,year:s,section_id:d,special_name:a,url_doi:"2394-5079.2024.132",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F5ac60c83-bd5b-4c02-b684-94edd0c5509e\u002Fhr100132.pdf",video_url:a,allauthors:"\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Yuqi Feng'\u003E Yuqi Feng, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Letian Fang'\u003E Letian Fang, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Guangwen Cao'\u003E Guangwen Cao\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-8094-1278' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Guangwen Cao'\u003E\u003C\u002Fa\u003E",journal_path:b,video_img:a,image_list:S,abstract:"\u003Cp\u003EPrimary liver cancer (PLC), which includes hepatocellular carcinoma (HCC, 93% in China; 75%-80% worldwide), intrahepatic cholangiocarcinoma (ICC, 4.3% in China; 10%-15% worldwide), and combined hepatocellular cholangiocarcinoma (CHC, 1.6% in China), is a global disease that brings a heavy burden to the world and the number of incidence cases is on the rise. Chronic liver injury caused by factors such as exposure to aflatoxin B1, infection with Clonorchis sinensis, heavy alcohol consumption, chronic infection with hepatitis C virus (HCV), and metabolic syndrome are all known risk factors for PLC. Notably, chronic infection with hepatitis B virus (HBV) is the major risk factor for HCC. Globally, PLC risk factors are changing from infectious causes to metabolic factors. Here, we update the mechanisms of HBV-related HCC (HBV-HCC) development, especially the effect of HBV evolution on the development of HCC. The HBV mutations, viral load, and HBV integration, together with parameters of poor liver function, are key components to define the highest-risk population of HBV-HCC. Antiviral therapy has been proven to be effective for the prevention of HBV-HCC in the highest-risk population. Non-invasive imaging combined with key markers is economical and convenient for screening early PLC. Surgical resection and liver transplantation are therapeutic options for HCC; however, postoperative recurrence reaches 70% in five years. Targeted therapy, immunotherapy, and radiotherapy can improve the survival of PLC. Active prophylaxes, including HBV vaccination, antiviral treatment, improving lifestyle to decrease chronic inflammation, and surveillance, are cost-effective in decreasing the disease burden of PLC.\u003C\u002Fp\u003E"},{article_id:"7615",title:"The application of artificial intelligence-based tools in the management of hepatocellular carcinoma: current status and future perspectives",image:T,tag:h,doi:"10.20517\u002F2394-5079.2024.126",date_published:U,section:j,authors:"Ciro Celsa\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-5662-2162' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Ciro Celsa'\u003E\u003C\u002Fa\u003E, ... Calogero Cammà",journal_id:f,volume:n,year:s,section_id:d,special_name:a,url_doi:"2394-5079.2024.126",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F98106d8e-8b66-4cab-aba4-3439e25a375f\u002Fhr100126.pdf",video_url:a,allauthors:"\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Ciro Celsa'\u003E Ciro Celsa\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-5662-2162' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Ciro Celsa'\u003E\u003C\u002Fa\u003E, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Alessio Quartararo'\u003E Alessio Quartararo, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Marcello Maida'\u003E Marcello Maida, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Gaetano Giusino'\u003E Gaetano Giusino, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Valeria Gaudioso'\u003E Valeria Gaudioso, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Alba Sparacino'\u003E Alba Sparacino, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Guido Cusimano'\u003E Guido Cusimano, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Sofia Rao'\u003E Sofia Rao, ... \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Calogero Cammà'\u003E Calogero Cammà",journal_path:b,video_img:a,image_list:T,abstract:"\u003Cp\u003EArtificial intelligence (AI) is rapidly advancing in hepatocellular carcinoma (HCC) management, offering promising applications across diagnosis, prognosis, and treatment. In histopathology, deep learning models have shown impressive accuracy in differentiating liver lesions and extracting prognostic information from tissue samples. For biomarker discovery, AI techniques applied to multi-omics data have identified novel prognostic signatures and predictors of immunotherapy response. In radiology, convolutional neural networks have demonstrated high performance in classifying hepatic lesions, grading tumors, and predicting microvascular invasion from computed tomography (CT) and magnetic resonance imaging (MRI) images. Multimodal AI models integrating histopathology, genomics, and clinical data are emerging as powerful tools for risk stratification. Large language models (LLMs) show potential to support clinical decision making and patient education, though concerns about accuracy remain. While AI holds immense promise, several challenges must be addressed, including algorithmic bias, data privacy, and regulatory compliance. The successful implementation of AI in HCC care will require ongoing collaboration between clinicians, data scientists, and ethicists. As AI technologies continue to evolve, they are expected to enable more personalized approaches to HCC management, potentially improving diagnosis, treatment selection, and patient outcomes. However, it is crucial to recognize that AI tools are designed to assist, not replace, clinical expertise. Continuous validation in diverse, real-world settings will be essential to ensure the reliability and generalizability of AI models in HCC care.\u003C\u002Fp\u003E"},{article_id:"7614",title:"Technical tips for indocyanine green-guided minimally invasive anatomical liver resection",image:d,tag:g,doi:"10.20517\u002F2394-5079.2024.111",date_published:U,section:"Technical Note",authors:"Nita Thiruchelvam\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0003-2097-1552' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Nita Thiruchelvam'\u003E\u003C\u002Fa\u003E, ... Ji Hoon Kim",journal_id:f,volume:n,year:s,section_id:d,special_name:a,url_doi:"2394-5079.2024.111",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F1aa49aaf-4b58-434b-a7a3-4659295d9765\u002Fhr100111.pdf",video_url:a,allauthors:"\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Nita Thiruchelvam'\u003E Nita Thiruchelvam\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0003-2097-1552' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Nita Thiruchelvam'\u003E\u003C\u002Fa\u003E, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Suet Yan Ong'\u003E Suet Yan Ong, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Hiang Jin Tan'\u003E Hiang Jin Tan, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Adrian Kah Heng Chiow'\u003E Adrian Kah Heng Chiow, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Ji Hoon Kim'\u003E Ji Hoon Kim",journal_path:b,video_img:a,image_list:d,abstract:"\u003Cp\u003EMinimally invasive anatomical liver resection is increasingly feasible due to the improved availability of preoperative 3-dimensional (3D) reconstruction of the liver as well as endoscopic cameras with near-infrared indocyanine green fluorescence overlay visualization. In this article, we share our experience and perceived benefits of anatomical liver resection with preoperative 3D liver reconstruction, provide technical tips to improve success at pedicle isolation and address common pitfalls that may be encountered by adopters early on their learning curve.\u003C\u002Fp\u003E"},{article_id:"7599",title:"Variation in attributable fraction of hepatitis B virus and hepatitis C virus among primary liver cancer cases across mainland China: a systematic literature review and meta-analysis",image:d,tag:e,doi:"10.20517\u002F2394-5079.2024.84",date_published:"1735920000",section:"Meta-Analysis",authors:"Chunqing Lin, ... Gary M. Clifford",journal_id:f,volume:n,year:s,section_id:d,special_name:a,url_doi:"2394-5079.2024.84",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F7bd36fb4-9ea4-49ef-988d-d818d9d4eccb\u002Fhr10084.pdf",video_url:a,allauthors:"\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Chunqing Lin'\u003E Chunqing Lin, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Zhenqiu Liu'\u003E Zhenqiu Liu, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Feixue Wei'\u003E Feixue Wei, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Catherine de Martel'\u003E Catherine de Martel, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Wanqing Chen'\u003E Wanqing Chen, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Gary M. Clifford'\u003E Gary M. Clifford",journal_path:b,video_img:a,image_list:d,abstract:"\u003Cp\u003E\u003Cb\u003EAim:\u003C\u002Fb\u003E Our objective was to describe variations in attributable fractions (AFs) of hepatitis B virus (HBV) and hepatitis C virus (HCV) to primary liver cancer (PLC) across mainland China.\u003C\u002Fp\u003E\u003Cp\u003E\u003Cb\u003EMethods:\u003C\u002Fb\u003E We conducted a systematic review and meta-analysis of studies published up to July 2024 in PubMed, Embase, WanFang, and China National Knowledge Infrastructure. Eligible studies reported the prevalence of HBV and HCV infection, alone and in combination, in PLC. AFs of HBV, HCV, and non-viral etiology in PLC were estimated by province and, when possible, by sex, age, histological diagnosis, and study periods. Regional and overall AFs were estimated by weighting by provincial and regional population size. Publication bias and heterogeneity were assessed by funnel plots of AFs of HBV, HCV, and non-viral etiology in PLC cases, using Egger test by study size.\u003C\u002Fp\u003E\u003Cp\u003E\u003Cb\u003EResults:\u003C\u002Fb\u003E We included 240 studies with 71,905 PLC cases from 31 provinces, autonomous regions and municipalities across mainland China. AFs of HBV, HCV, and non-viral etiology for PLC across mainland China were 76.5%, 6.6%, and 16.9%, respectively. The AFs of HBV and HCV varied by region, with HBV AFs ranging from 68.7% in Northwest China to 82.9% in South Central China. Respective HCV AFs ranged from 12.7% in Northeast China down to 3.7% in South Central China. Non-viral AFs ranged from 13.4% to 21.0% by region. AFs of non-viral etiology were 57.9% in intrahepatic cholangiocarcinoma (ICC), and AF of HBV was double prevalence ratio (PR), 2.11 (95%CI: 1.89-2.34) in hepatocellular carcinoma (HCC, 76.3%) than ICC (37.3%) cases. Prevalence of HBV was higher in male (83.9%) than female (74.6%) PLC cases, and the mean age at diagnosis was 10 years higher for PLC with HCV (64.9 years) than HBV (54.4 years).\u003C\u002Fp\u003E\u003Cp\u003E\u003Cb\u003EConclusion:\u003C\u002Fb\u003E HBV, HCV, and non-viral AFs varied substantially by region across China, as well as by sex and age, which can inform strategies for liver cancer prevention and control.\u003C\u002Fp\u003E"}],recent_ids:"7696,7672,7615,7614,7599",view:[{article_id:"1461",title:"Role of natural antioxidants in the therapeutic management of hepatocellular carcinoma",image:d,tag:"216-23",doi:"10.20517\u002F2394-5079.2016.12",date_published:"1470326400",section:j,authors:"Hanaa A. Hassan\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-8545-0152' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Hanaa A. Hassan'\u003E\u003C\u002Fa\u003E, ... Anmar F. Azhari",journal_id:f,volume:e,year:D,section_id:d,special_name:a,url_doi:"2394-5079.2016.12",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F07093cd7-12f9-4566-9556-fb37f75bcf0d\u002F1461.pdf",video_url:a,allauthors:"Hanaa A. Hassan\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-8545-0152' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Hanaa A. Hassan'\u003E\u003C\u002Fa\u003E, Nermin E. El-Gharib, Anmar F. Azhari",journal_path:b,video_img:a,image_list:d,abstract:"\u003Cp\u003E Hepatocellular carcinoma (HCC) is a growing health problem in humans. HCC is considered the most common of internal malignancy which cause the death of human, but in the developed Western world, HCC is less common accompanied by increasing essentially in incidence, due to it occurs specially in chronic liver disease. HCC associated with various risk factors including hepatitis B virus infection; hepatitis C virus infection; prolonged aflatoxin exposure; and alcoholic cirrhosis. Overall, one-third of cirrhosis patients will develop HCC during their life time. Also, chemical carcinogens cause tumor promotions through free radical metabolites result in many biochemical and molecular changes that induces oxidative stress. The identify of HCC stage and underlying liver status then choosing the most appropriate line of therapy (surgical, loco regional, radiological and medical) can be improve the survival and\u002For the quality of life of the patient. Taken into the account of the nutritional value of some natural antioxidant agents that support the function of the body resulting an improvement of the health and protection from different diseases, our review will provide an up-dated status of the different aspects of HCC management through covering the efficacy and the beneficial effects of different natural agents and their mechanism of action against HCC for the future therapy modalities. \u003C\u002Fp\u003E"},{article_id:V,title:W,image:u,tag:X,doi:Y,date_published:Z,section:j,authors:_,journal_id:f,volume:e,year:D,section_id:d,special_name:a,url_doi:$,pdf:aa,video_url:a,allauthors:"R. Jason Lamontagne, Sumedha Bagga, Michael J. Bouchard\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0003-3523-5347' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Michael J. Bouchard'\u003E\u003C\u002Fa\u003E",journal_path:b,video_img:a,image_list:u,abstract:ab},{article_id:"1162",title:"Can sorafenib be discontinued in hepatocellular carcinoma patients with a complete response to treatment?",image:d,tag:"109-10",doi:"10.4103\u002F2394-5079.161332",date_published:ac,section:"Editorial",authors:"Jing Li, ... Yi-Qun Yan\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0001-9546-5481' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Yi-Qun Yan'\u003E\u003C\u002Fa\u003E",journal_id:f,volume:c,year:E,section_id:"54",special_name:ad,url_doi:"2394-5079.161332",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F7c049713-77db-41f2-88a6-f8c5badf8805\u002F1162.pdf",video_url:a,allauthors:"Jing Li, Liang Huang, Yi-Qun Yan\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0001-9546-5481' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Yi-Qun Yan'\u003E\u003C\u002Fa\u003E",journal_path:b,video_img:a,image_list:d,abstract:a},{article_id:"1890",title:"Radiological diagnosis of hepatocellular carcinoma in non-cirrhotic patients",image:ae,tag:"1-17",doi:"10.20517\u002F2394-5079.2015.62",date_published:"1484150400",section:j,authors:"Alba Castán, ... Alejandro Serrablo",journal_id:f,volume:g,year:"2017",section_id:d,special_name:a,url_doi:"2394-5079.2015.62",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F5d49a3d6-b020-45bb-9389-ec41704589e7\u002F1890.pdf",video_url:a,allauthors:"Alba Castán, Ylenia Navarro, Luis Sarría, Raquel Larrosa, Mario Serradilla, Alejandro Serrablo",journal_path:b,video_img:a,image_list:ae,abstract:"\u003Cp\u003E Hepatocellular carcinoma (HCC) arising in non-cirrhotic livers is relatively rare. Compared with HCC arising in cirrhotic livers they have some quirks. HCC in healthy livers are large tumors at diagnosis, and are detected due to the onset of abdominal symptoms, outside of any scheduled monitoring program. In non-cirrhotic patients, HCC has the same appearance as the classic image of cirrhotic HCC substrate. The presence of capsule, extensive intratumoral necrosis and typical behavior in the dynamic study after administration of intravenous contrast are present in most of the non-cirrhotic livers. In the presence of a suspicious lesion of HCC, we must assess the existence of underlying chronic liver disease. Ultrasound, computed tomography, and conventional magnetic resonance are imaging techniques that have a high specificity for the diagnosis of cirrhosis, but exhibit low sensitivity for diagnosis in the early stages of the disease. In recent years, new imaging methods are being developed to assess emerging liver fibrosis. In particular, in patients without chronic liver disease it is imperative to consider the differential diagnosis with other tumors that may settle in healthy livers with similar radiological characteristics as HCC. Therefore, in the presence of a lesion with pathognomonic radiological characteristics of HCC in the absence of cirrhosis, biopsy is required. \u003C\u002Fp\u003E"},{article_id:"1170",title:"\"PERISH\" flowchart for selection of the patients with resectable hepatocellular carcinoma",image:af,tag:"165-70",doi:"10.4103\u002F2394-5079.161329",date_published:ac,section:j,authors:"Cuneyt Kayaalp\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0003-4657-2998' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Cuneyt Kayaalp'\u003E\u003C\u002Fa\u003E, ... Mehmet Caglikulekci",journal_id:f,volume:c,year:E,section_id:d,special_name:a,url_doi:"2394-5079.161329",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F6a477f05-3a41-4881-b38d-ff8b3458d210\u002F1170.pdf",video_url:a,allauthors:"Cuneyt Kayaalp\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0003-4657-2998' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Cuneyt Kayaalp'\u003E\u003C\u002Fa\u003E, H. Kerem Tolan, Mehmet Caglikulekci",journal_path:b,video_img:a,image_list:af,abstract:"\u003Cp\u003E A selection of patients with hepatocellular carcinoma (HCC) for surgical resection is crucial and algorithms\u002Fstaging systems help surgeons to decide on a standard treatment for each patient and each HCC stage. However, there are always difficulties in remembering and\u002For recalling the contents of the algorithms\u002Fstaging systems. Moreover, most algorithms\u002Fstaging systems don’t include data about the extent of hepatectomy, intra-hepatic distribution of tumor(s), and technical feasibility of resection, all of which are vital in the surgeons’ decision-making process. Here, we aimed to present a simple and handy mnemonic acronym for selecting resectable HCCs in surgical practice. This was reproduced from the existing well-known staging systems. The designed mnemonic acronym is a phrase “PERISH” and it includes asking for Performance of patient, Extra-hepatic disease, Reserve of liver, Intra-hepatic distribution, Stratifying risk factors, and Hepatectomy size in order. Performance based on whether the patient is mostly bedridden or not, should be the first step of evaluation. Next, asking for suspicious metastasis as bone pain and radiological evaluation of abdomen\u002Fthorax is mandatory. The calculation of Child-Pugh score is only the third step. Good candidates for surgical resection should be Child-Pugh “A” with normal bilirubin levels. Technical feasibility of resection according to the intra-hepatic distribution of tumor(s) should be done later and the candidates preferably should not have portal hypertension (no splenomegaly, no thrombocytopenia). If the patient fulfils all the previous steps, the surgeon may perform indo-cyanine green clearance test. Consequently, following the PERISH flowchart may prevent “perish” of the surgeons while selecting the appropriate resectable HCCs. \u003C\u002Fp\u003E"}],view_ids:"1461,1318,1162,1890,1170",download:[{article_id:V,title:W,image:u,tag:X,doi:Y,date_published:Z,section:j,authors:_,journal_id:f,volume:e,year:D,section_id:d,special_name:a,url_doi:$,pdf:aa,video_url:a,allauthors:"\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='R. Jason Lamontagne'\u003E R. Jason Lamontagne, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Sumedha Bagga'\u003E Sumedha Bagga, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Michael J. Bouchard'\u003E Michael J. Bouchard\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0003-3523-5347' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Michael J. Bouchard'\u003E\u003C\u002Fa\u003E",journal_path:b,video_img:a,image_list:u,abstract:ab},{article_id:"4511",title:N,image:ag,tag:h,doi:"10.20517\u002F2394-5079.2021.106",date_published:"1641484800",section:j,authors:"Doreen Maria Gisder\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-9226-5916' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Doreen Maria Gisder'\u003E\u003C\u002Fa\u003E, ... Iris Tischoff",journal_id:f,volume:v,year:"2022",section_id:d,special_name:a,url_doi:M,pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002Fb2c03eca-0ed1-4345-9b0f-2041d9c92d36\u002F4511.pdf",video_url:a,allauthors:"\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Doreen Maria Gisder'\u003E Doreen Maria Gisder\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-9226-5916' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Doreen Maria Gisder'\u003E\u003C\u002Fa\u003E, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Andrea Tannapfel'\u003E Andrea Tannapfel, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Iris Tischoff'\u003E Iris Tischoff",journal_path:b,video_img:a,image_list:ag,abstract:"\u003Cp\u003EWhen do you need to take biopsies of the liver, and what information will you get is the topic of this review on hepatocellular carcinoma (HCC). If, clinically, the differential diagnosis of HCC after imaging is suggested, a biopsy has become obligatory as a diagnostic confirmation of HCC in the non-cirrhotic liver prior to definitive therapeutic interventions, as well as in a palliative therapy concept. In the case of hepatic lesions with an uncharacteristic contrast uptake, a biopsy should be performed immediately to confirm the diagnosis of HCC. After diagnosing HCC, a treatment strategy is evaluated. Further, the biopsy, or in case of surgical treatment, the resected tissue, shows us the different subtypes of HCC, with the steatohepatitic subtype being the most common and the lymphocyte-rich subtype being the least common. Further, the histological grade of HCC is determined according to the grading system of the WHO or the Edmonson and Steiner System. Through biopsies, HCC can be differentiated from intrahepatic cholangiocarcinoma or combined hepatocellular-cholangiocarcinoma or metastases of other malignant tumors, especially metastases of the gastrointestinal tract. In summary, biopsies are fundamental in the diagnosis of HCC.\u003C\u002Fp\u003E"},{article_id:"3223",title:"The use of cell free DNA in the diagnosis of HCC",image:ah,tag:"34",doi:"10.20517\u002F2394-5079.2019.30",date_published:"1569168000",section:j,authors:"Bubu A. Banini, Arun J. Sanyal\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0001-8682-5748' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Arun J. Sanyal'\u003E\u003C\u002Fa\u003E",journal_id:f,volume:i,year:ai,section_id:"208",special_name:aj,url_doi:"2394-5079.2019.30",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F38048865-c564-4c57-abd0-150716a441ea\u002F3223.pdf",video_url:a,allauthors:"\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Bubu A. Banini'\u003E Bubu A. Banini, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Arun J. Sanyal'\u003E Arun J. Sanyal\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0001-8682-5748' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Arun J. Sanyal'\u003E\u003C\u002Fa\u003E",journal_path:b,video_img:a,image_list:ah,abstract:"\u003Cp\u003EHepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and is associated with high mortality. The currently used methods for diagnosing HCC, including imaging modalities and liver biopsy, detect tumors at a relatively advanced stage or are invasive. Non-invasive biomarkers are urgently needed to facilitate screening and early diagnosis of HCC, as well as treatment monitoring and detection of tumor recurrence. Liquid biopsy, the analysis of blood or other body fluids to obtain genetic and epigenetic information, has historically been applied to other types of cancer including breast and prostate cancer. Over the past few decades, liquid biopsy analysis has shed significant insights on genetic and epigenetic aberrations in HCC detectable in peripheral blood. Aberrations in nucleic acids found circulating freely in body fluids or contained within extracellular vesicles such as exosomes or microvesicles show potential clinical utility as non-invasive biomarkers. In this review, we present available literature on cell-free nucleic acids in the diagnosis of HCC.\u003C\u002Fp\u003E"},{article_id:"3175",title:"Management of concomitant hepatocellular carcinoma and chronic hepatitis C: a review",image:ak,tag:"28",doi:"10.20517\u002F2394-5079.2019.15",date_published:"1564329600",section:j,authors:"Elizabeth Harrod, ... Behnam Saberi\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-7157-5827' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Behnam Saberi'\u003E\u003C\u002Fa\u003E",journal_id:f,volume:i,year:ai,section_id:d,special_name:a,url_doi:"2394-5079.2019.15",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F654b2130-c802-4b9b-b080-84b637a90733\u002F3175.pdf",video_url:a,allauthors:"\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Elizabeth Harrod'\u003E Elizabeth Harrod, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Carlos Moctezuma-Velazquez'\u003E Carlos Moctezuma-Velazquez, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Ahmet Gurakar'\u003E Ahmet Gurakar, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Aftab Ala'\u003E Aftab Ala, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Douglas Dieterich'\u003E Douglas Dieterich, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Behnam Saberi'\u003E Behnam Saberi\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-7157-5827' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Behnam Saberi'\u003E\u003C\u002Fa\u003E",journal_path:b,video_img:a,image_list:ak,abstract:"\u003Cp\u003EOur comprehensive review focuses on the treatment of hepatitis C virus in the context of hepatocellular carcinoma and vice versa, highlighting the ongoing complexity of this clinical scenario. There remain multiple unanswered questions when considering the management of these complex patients and, with a rapidly-changing treatment landscape for both chronic hepatitis C and hepatocellular carcinoma, these questions are only going to grow. Treatment timing, interactions and the impact of one disease condition on the other are vitally important, though guidance generally remains non-specific, suggesting that we make these decisions on a case-by-case basis. We focus on the current evidence for managing these cases, depending on disease stage and treatment type.\u003C\u002Fp\u003E"},{article_id:"2616",title:"Intrahepatic cholangiocarcinoma: review and update",image:al,tag:"20",doi:"10.20517\u002F2394-5079.2018.46",date_published:"1529337600",section:j,authors:"Vincenzo Cardinale, ... Domenico Alvaro\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0003-3771-9644' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Domenico Alvaro'\u003E\u003C\u002Fa\u003E",journal_id:f,volume:h,year:"2018",section_id:"181",special_name:am,url_doi:"2394-5079.2018.46",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F2f19ef59-f382-412e-8a29-8c6e50676bd8\u002F2616.pdf",video_url:a,allauthors:"\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Vincenzo Cardinale'\u003E Vincenzo Cardinale, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Maria Consiglia Bragazzi'\u003E Maria Consiglia Bragazzi, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Guido Carpino'\u003E Guido Carpino, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Sabina Di Matteo'\u003E Sabina Di Matteo, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Diletta Overi'\u003E Diletta Overi, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Lorenzo Nevi'\u003E Lorenzo Nevi, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Eugenio Gaudio'\u003E Eugenio Gaudio, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Domenico Alvaro'\u003E Domenico Alvaro\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0003-3771-9644' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Domenico Alvaro'\u003E\u003C\u002Fa\u003E",journal_path:b,video_img:a,image_list:al,abstract:"\u003Cp\u003E Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies that could develop at any level from the biliary tree. CCA is currently classified into intrahepatic (iCCA), perihilar and distal on the basis of its anatomical location. Of note, these three CCA subtypes have common features but also important inter-tumor and intra-tumor differences that can affect the pathogenesis and outcome. A unique feature of iCCA is that it recognizes as origin tissues, the hepatic parenchyma or large intrahepatic and extrahepatic bile ducts, which are furnished by two distinct stem cell niches, the canals of Hering and the peribiliary glands, respectively. The complexity of iCCA pathogenesis highlights the need of a multidisciplinary, translational and systemic approach to this malignancy. This review will focus on the advances of iCCA epidemiology, histo-morphology, risk factors, molecular pathogenesis, revealing the existence of multiple subsets of iCCA. \u003C\u002Fp\u003E"}],download_ids:"1318,4511,3223,3175,2616"},cited:[{article_id:"6698",title:"Dysmetabolic comorbidities and non-alcoholic fatty liver disease: a stairway to metabolic dysfunction-associated steatotic liver disease",image:d,tag:"16",doi:"10.20517\u002F2394-5079.2023.134",date_published:"1711641600",section:j,authors:"Carmen Colaci, ... Ludovico Abenavoli\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-5922-1524' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Ludovico Abenavoli'\u003E\u003C\u002Fa\u003E",journal_id:f,volume:F,year:"2024",section_id:"520",special_name:"Topic: Diet, Liver Diseases, Liver Cancer: Prevention from the Source",url_doi:"2394-5079.2023.134",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F054d92d3-a431-4da4-86b2-5d5b8fc82df3\u002Fhr30134.pdf",video_url:a,allauthors:"\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Carmen Colaci'\u003E Carmen Colaci, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Maria Luisa Gambardella'\u003E Maria Luisa Gambardella, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Giuseppe Guido Maria Scarlata'\u003E Giuseppe Guido Maria Scarlata\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-7084-8264' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Giuseppe Guido Maria Scarlata'\u003E\u003C\u002Fa\u003E, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Luigi Boccuto'\u003E Luigi Boccuto\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0003-2017-4270' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Luigi Boccuto'\u003E\u003C\u002Fa\u003E, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Carmela Colica'\u003E Carmela Colica, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Francesco Luzza'\u003E Francesco Luzza, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Emidio Scarpellini'\u003E Emidio Scarpellini, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Nahum Mendez-Sanchez'\u003E Nahum Mendez-Sanchez\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0001-5257-8048' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Nahum Mendez-Sanchez'\u003E\u003C\u002Fa\u003E, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Ludovico Abenavoli'\u003E Ludovico Abenavoli\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-5922-1524' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Ludovico Abenavoli'\u003E\u003C\u002Fa\u003E",journal_path:b,video_img:a,image_list:d,abstract:"\u003Cp\u003ENon-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. This term does not describe the pathogenetic mechanisms and complications associated with NAFLD. The new definition, Metabolic Dysfunction-associated Steatotic Liver disease (MASLD), emphasizes the relationship between NAFLD and cardiometabolic comorbidities. Cardiovascular disease features, such as arterial hypertension and atherosclerosis, are frequently associated with patients with MASLD. Furthermore, these patients have a high risk of developing neoplastic diseases, primarily hepatocellular carcinoma, but also extrahepatic tumors, such as esophageal, gastric, and pancreatic cancers. Moreover, several studies showed the correlation between MASLD and endocrine disease. The imbalance of the gut microbiota, systemic inflammation, obesity, and insulin resistance play a key role in the development of these complications. This narrative review aims to clarify the evolution from NAFLD to the new nomenclature MASLD and evaluate its complications.\u003C\u002Fp\u003E"},{article_id:"5522",title:"Issue on combined locoregional and systemic treatment for hepatocellular carcinoma",image:an,tag:k,doi:"10.20517\u002F2394-5079.2022.37",date_published:"1678896000",section:j,authors:"Yi-Chia (Jasmine) Wu, ... Nikolaos Pyrsopoulos",journal_id:f,volume:t,year:ao,section_id:"555",special_name:ap,url_doi:"2394-5079.2022.37",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F4ef7613b-3b3d-4df4-8269-80973e9d702e\u002F5522.pdf",video_url:a,allauthors:"\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Yi-Chia (Jasmine) Wu'\u003E Yi-Chia (Jasmine) Wu, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Ali Wakil'\u003E Ali Wakil\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0002-9377-4691' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Ali Wakil'\u003E\u003C\u002Fa\u003E, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Fayssa Salomon'\u003E Fayssa Salomon, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Nikolaos Pyrsopoulos'\u003E Nikolaos Pyrsopoulos",journal_path:b,video_img:a,image_list:an,abstract:"\u003Cp\u003ETreatment for hepatocellular carcinoma (HCC) has been challenging as most patients present with late, advanced disease, where curative options are limited. For years, locoregional therapy (LRT) has been the first-line therapy for intermediate-stage HCC and sorafenib for advanced HCC. However, these treatments are often palliative since they are plagued by tumor recurrence or progression. Therefore, there is growing interest in combined therapy to utilize their respective strengths to produce synergistic effects. This review outlines past and current research on the efficacy and safety of combined LRT and systemic therapy.\u003C\u002Fp\u003E"},{article_id:"6268",title:"Barriers to surveillance for hepatocellular cancer among patients with chronic liver disease -providers' perspectives",image:aq,tag:"45",doi:"10.20517\u002F2394-5079.2023.75",date_published:"1698595200",section:"Original Article",authors:"Eliza W. Beal\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0003-2191-6811' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Eliza W. Beal'\u003E\u003C\u002Fa\u003E, ... Allan Tsung",journal_id:f,volume:t,year:ao,section_id:d,special_name:a,url_doi:"2394-5079.2023.75",pdf:"https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002Fc66f3994-0425-4137-8db0-85ca59b11ca6\u002Fhr9075.pdf",video_url:a,allauthors:"\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Eliza W. Beal'\u003E Eliza W. Beal\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0003-2191-6811' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Eliza W. Beal'\u003E\u003C\u002Fa\u003E, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Leva Gorji'\u003E Leva Gorji, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Jaclyn Volney'\u003E Jaclyn Volney, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Lindsey Sova'\u003E Lindsey Sova, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Ann Scheck McAlearney'\u003E Ann Scheck McAlearney, \u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Fdefault_photo.png' class='author_photo' alt='Allan Tsung'\u003E Allan Tsung",journal_path:b,video_img:a,image_list:aq,abstract:"\u003Cp\u003E\u003Cb\u003EAims:\u003C\u002Fb\u003E Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. While patients who are known to be at high risk for HCC should be under surveillance, only 20% of eligible patients in the United States are surveilled. The aim of this study was to identify providers’ perspectives about patient-, provider- and system-level barriers to surveillance for HCC among high-risk patients and to examine provider knowledge and attitudes related to HCC surveillance. We also explored interventions providers suggested as ways to improve HCC surveillance.\u003C\u002Fp\u003E\u003Cp\u003E\u003Cb\u003EMethods:\u003C\u002Fb\u003E Purposive sampling was used to recruit physicians and nurse practitioners in hepatology, gastroenterology, and primary care (internal and family medicine) from one academic medical center to participate in semi-structured interviews. Interviews were transcribed verbatim, and analyzed deductively and inductively to reveal emergent themes.\u003C\u002Fp\u003E\u003Cp\u003E\u003Cb\u003EResults:\u003C\u002Fb\u003E 22 informants were interviewed. During these interviews, several important themes emerged, including: (1) Provider comfort with managing chronic liver disease and the relationships between hepatology, gastroenterology, infectious disease, and primary care providers; (2) Provider knowledge of guidelines for HCC surveillance in high-risk patients and their knowledge about the impact that HCC surveillance can have; (3) How providers discuss HCC surveillance with their high-risk patients; (4) Provider-Level barriers to surveillance; (5) System-level barriers to surveillance; (6) COVID-19; (7) Patient-level barriers to surveillance, and (8) Suggested interventions to improve HCC surveillance rates.\u003C\u002Fp\u003E\u003Cp\u003E\u003Cb\u003EConclusions:\u003C\u002Fb\u003E In designing interventions to improve HCC surveillance rates of high-risk patients in the United States, there are important targets at the patient, provider and system 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Res",ad:[],colour_tag:"#f3906d",score:a,mobile_top_img:a,impact_factor:[{factor:"https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20240313\u002Fee358186a06449d5b2c8ea15f712cbed.png",url:bc},{factor:"https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20240625\u002Faf5ee9028a554c6aa6f0030bbcbfe55d.png",url:"https:\u002F\u002Fjcr.clarivate.com\u002Fjcr-jp\u002Fjournal-profile?journal=HEPATOMA%20RES&year=2023"},{factor:"https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20240506\u002Fea3d9071c35b4bf3982ffe25f1083620.png",url:bb}],rgba:"rgb(239,108,62)",log_image:"https:\u002F\u002Fi.oaes.cc\u002Fupload\u002Fjournal_logo\u002Fhr.jpg"},webinfo:{},searchKey:a,loading:bd,appid:a,videoPlay:{show:B,href:a}},editer:{editList:{list:{}}},userdata:{showLogin:B,logined:B}},serverRendered:bd,routePath:L,config:{_app:{basePath:be,assetsPath:be,cdnURL:"https:\u002F\u002Fg.oaes.cc\u002Foae\u002Fnuxt\u002F"}}}}("","hr","1","0","2","7","3","4","5","Review","6",-1,7,"11","editor_Haidi@hrjournal.net","editor_Victoria@hrjournal.net","editor001@hrjournal.net","image","2025","9","https:\u002F\u002Fimage.oaes.cc\u002F19004548-2838-4795-b305-a0d54c68afcb\u002F1318-coverimg.jpg","8",0,15,8,25,"editorialoffice@hrjournal.net",false,285,"2016","2015","10",12,18,6,"Contact Us","Hepatoma Research","\u002Fhr","2394-5079.2021.106","Histopathology of hepatocellular carcinoma - when and what",284,282,"https:\u002F\u002Fimage.oaes.cc\u002F92b4eee0-1e12-4592-b8a0-8b477e8cf88d\u002Fhr100124-coverimg.jpg","Topic: Advances in Precision Medicine for HCC","https:\u002F\u002Fimage.oaes.cc\u002F5ac60c83-bd5b-4c02-b684-94edd0c5509e\u002Fhr100132-coverimg.jpg","https:\u002F\u002Fimage.oaes.cc\u002F98106d8e-8b66-4cab-aba4-3439e25a375f\u002Fhr100126-coverimg.jpg","1736352000","1318","Hepatitis B virus molecular biology and pathogenesis","163-86","10.20517\u002F2394-5079.2016.05","1467302400","R. Jason Lamontagne, ... Michael J. Bouchard\u003Ca href='https:\u002F\u002Forcid.org\u002F0000-0003-3523-5347' target='_blank'\u003E\u003Cimg src='https:\u002F\u002Fi.oaes.cc\u002Fimages\u002Forcid.png' class='author_id' alt='Michael J. Bouchard'\u003E\u003C\u002Fa\u003E","2394-5079.2016.05","https:\u002F\u002Ff.oaes.cc\u002Fxmlpdf\u002F19004548-2838-4795-b305-a0d54c68afcb\u002F1318.pdf","\u003Cp\u003E As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular signaling processes. While beneficial for the viral replication cycle, virus-induced deregulation of host cellular signaling processes can be detrimental to host cell physiology and can lead to virus-associated pathogenesis, including, for oncogenic viruses, cell transformation and cancer progression. Included among these oncogenic viruses is the hepatitis B virus (HBV). Despite the availability of an HBV vaccine, 350-500 million people worldwide are chronically infected with HBV, and a significant number of these chronically infected individuals will develop hepatocellular carcinoma (HCC). Epidemiological studies indicate that chronic infection with HBV is the leading risk factor for the development of HCC. Globally, HCC is the second highest cause of cancer-associated deaths, underscoring the need for understanding mechanisms that regulate HBV replication and the development of HBV-associated HCC. HBV is the prototype member of the \u003Ci\u003EHepadnaviridae\u003C\u002Fi\u003E family; members of this family of viruses have a narrow host range and predominately infect hepatocytes in their respective hosts. The extremely small and compact hepadnaviral genome, the unique arrangement of open reading frames, and a replication strategy utilizing reverse transcription of an RNA intermediate to generate the DNA genome are distinguishing features of the \u003Ci\u003EHepadnaviridae\u003C\u002Fi\u003E. In this review, the authors provide a comprehensive description of HBV biology, summarize the model systems used for studying HBV infections, and highlight potential mechanisms that link a chronic HBV-infection to the development of HCC. For example, the HBV X protein (HBx), a key regulatory HBV protein that is important for HBV replication, is thought to play a cofactor role in the development of HBV-induced HCC, and the authors highlight the functions of HBx that may contribute to the development of HBV-associated HCC. \u003C\u002Fp\u003E","1444838400","Topic: Natural Products and Hepatocellular Carcinoma","https:\u002F\u002Fimage.oaes.cc\u002F5d49a3d6-b020-45bb-9389-ec41704589e7\u002F1890-coverimg.jpg","https:\u002F\u002Fimage.oaes.cc\u002F6a477f05-3a41-4881-b38d-ff8b3458d210\u002F1170-coverimg.png","https:\u002F\u002Fimage.oaes.cc\u002Fb2c03eca-0ed1-4345-9b0f-2041d9c92d36\u002F4511-coverimg.jpg","https:\u002F\u002Fimage.oaes.cc\u002F38048865-c564-4c57-abd0-150716a441ea\u002F3223-coverimg.jpg","2019","Topic: Advances in the Early Diagnosis of HCC","https:\u002F\u002Fimage.oaes.cc\u002F654b2130-c802-4b9b-b080-84b637a90733\u002F3175-coverimg.jpg","https:\u002F\u002Fimage.oaes.cc\u002F2f19ef59-f382-412e-8a29-8c6e50676bd8\u002F2616-coverimg.jpg","Topic: New Insights in Liver Cancer","https:\u002F\u002Fimage.oaes.cc\u002F4ef7613b-3b3d-4df4-8269-80973e9d702e\u002F5522-coverimg.jpg","2023","Topic: Systemic Treatment for Hepatocellular Carcinoma","https:\u002F\u002Fimage.oaes.cc\u002Fc66f3994-0425-4137-8db0-85ca59b11ca6\u002Fhr9075-coverimg.jpg",287,"Amedeo Lonardo",208,182,288,210,180,522,1678838400,"https:\u002F\u002Fi.oaes.cc\u002Fuploads\u002F20231016\u002Fd00658dbe69d4cad8c4f48c20e41a30b.jpg","Topic: Systemic Therapy for Advanced Cholangiocarcinoma: New Options on the Horizon",405,1668470400,"https:\u002F\u002Fi.oaes.cc\u002Fpublic\u002Fissue_special\u002F405\u002F37_hr_sp405.jpg","Topic: Immunotherapy and Immunotherapy Biomarkers for Hepatocellular Carcinoma",13,16,"Journal of Cancer Metastasis and Treatment","Metabolism and Target Organ Damage",26,88,5,17,58,10,9,52,11,53,54,"About","Editorial Policies","Journals","12","5555","\u002Fhr\u002Fcontact_us","2454-2520 (Online) 2394-5079 (Print)","https:\u002F\u002Ftwitter.com\u002FHepatomaRes","https:\u002F\u002Fmjl.clarivate.com\u002Fsearch-results","https:\u002F\u002Fwww.scopus.com\u002Fsourceid\u002F21101058282",true,"\u002F"));</script><script src="https://g.oaes.cc/oae/nuxt/47b9fdf.js" defer></script><script src="https://g.oaes.cc/oae/nuxt/eac505e.js" defer></script><script src="https://g.oaes.cc/oae/nuxt/da5c032.js" defer></script><script src="https://g.oaes.cc/oae/nuxt/800bc65.js" defer></script><script src="https://g.oaes.cc/oae/nuxt/d5348f9.js" defer></script><script src="https://g.oaes.cc/oae/nuxt/7bf631b.js" defer></script> </body> </html> <div id="noIe" style="display: none;"> <style> #noIe { background: rgba(99, 125, 255, 1); width: 100%; height: 100vh; position: fixed; top: 0; left: 0; z-index: 999999; } #noIe .container { width: 802px; height: 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" 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