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xmlns:xlink="http://www.w3.org/1999/xlink"> <title>Search icon</title> <use xlink:href="#icon-search"></use> </svg> </label> </form> </div>       </div> </div> </header> <div class="hero"> <div class="hero__bottom"> <div class="hero__content"> <h1>Broadening our in vitro toxicology portfolio: DILIscope – drug induced liver injury screening service package available!</h1> <p class="hero__date">Posted on September 3, 2024</p> </div> </div> </div> <main class="wp-block-group main main--page is-layout-flow wp-block-group-is-layout-flow"><div class="entry-content main__content wp-block-post-content is-layout-flow wp-block-post-content-is-layout-flow"> <p>Building on our ongoing R&D advancements, we’re excited to announce the expansion of our in vitro toxicology portfolio with the launch of our new service package, <a href="https://admescope.com/services/in-vitro-toxicology/#DILIscope_hepatotoxicity_screening_service_package" target="_blank" rel="noreferrer noopener">DILIscope</a>!</p> <figure class="wp-block-image aligncenter size-full is-resized"><img fetchpriority="high" decoding="async" width="1000" height="1000" src="https://admescope.com/wp-content/uploads/sites/2/2024/09/NEW-DILI-services-2024.png" alt="" class="wp-image-5267" style="width:759px;height:759px" srcset="https://admescope.com/wp-content/uploads/sites/2/2024/09/NEW-DILI-services-2024.png 1000w, https://admescope.com/wp-content/uploads/sites/2/2024/09/NEW-DILI-services-2024-300x300.png 300w, https://admescope.com/wp-content/uploads/sites/2/2024/09/NEW-DILI-services-2024-150x150.png 150w, https://admescope.com/wp-content/uploads/sites/2/2024/09/NEW-DILI-services-2024-768x768.png 768w" sizes="(max-width: 1000px) 100vw, 1000px" /></figure> <h2 class="wp-block-heading has-medium-font-size"><strong><strong>What’s Included in DILIscope?</strong></strong></h2> <p>Drug-induced liver injury, DILI, often leading to acute liver failure, can be caused by several mechanisms and poses a challenge in drug discovery. Our approach to assess and mitigate the risk for hepatotoxicity and DILI utilizes automated high-content imaging including evaluation of early signs of hepatotoxicity and cell stress, steatosis, phospholipidosis and lysosomal trapping. Importantly, the assays employ pooled primary human hepatocytes to achieve complete metabolic function and acknowledge inter-individual variability in humans. With all these parameters evaluated, one can confidently screen for potential DILI risk related to the compounds and identify hazards. Furthermore, to gain further complimentary information, the compounds can be tested for whether they form reactive metabolites or inhibit transporters, which are also mechanisms of liver toxicity.</p> <figure class="wp-block-image size-large"><img decoding="async" width="1024" height="576" src="https://admescope.com/wp-content/uploads/sites/2/2024/09/DILInewsletter-2-1024x576.png" alt="" class="wp-image-5268" srcset="https://admescope.com/wp-content/uploads/sites/2/2024/09/DILInewsletter-2-1024x576.png 1024w, https://admescope.com/wp-content/uploads/sites/2/2024/09/DILInewsletter-2-300x169.png 300w, https://admescope.com/wp-content/uploads/sites/2/2024/09/DILInewsletter-2-768x432.png 768w, https://admescope.com/wp-content/uploads/sites/2/2024/09/DILInewsletter-2-1536x864.png 1536w, https://admescope.com/wp-content/uploads/sites/2/2024/09/DILInewsletter-2-2048x1152.png 2048w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure> <h2 class="wp-block-heading has-medium-font-size"><strong>Hepatotoxicity and cell stress</strong></h2> <p>The sensitive high-content screening cytotoxicity assay, conducted in pooled human hepatocytes, delivers multiple endpoints elucidating the mechanism behind potential hepatotoxicity. The assay gives information about basic functions such as cell loss and viability, membrane integrity as well as nuclei size and variation in their intensity. Additionally, mitochondrial function and production of reactive oxidative species are included; these are often the first signs of cellular toxicity and typical mechanism inducing DILI.</p> <h2 class="wp-block-heading has-medium-font-size"><strong>Steatosis and phospholipidosis</strong></h2> <p>Steatosis, marked by the buildup of fatty acids and lipids, and phospholipidosis, a sign of lysosomal malfunction and accumulation of phospholipids and lamellar bodies, may arise at concentrations of drugs lower than those causing cytotoxic effects, thereby increasing the risk for hepatotoxicity and pathogenic conditions such as of drug-induced fatty liver disease or steatohepatitis.</p> <h2 class="wp-block-heading has-medium-font-size"><strong><strong>Lysosomal trapping</strong></strong></h2> <p>Certain types of compounds may be prone to lysosomal trapping or sequestration, which impacts their pharmacokinetics, efficacy, and safety properties, and is also one of the mechanisms inducing phospholipidosis.聽Our cutting-edge lysosomal trapping assay utilizes Lysotracker dye to evaluate the lysosomal sequestration potential of drug candidates. When the test compound undergoes lysosomal sequestration, there’s a concentration-dependent decrease in the lysosomal fluorescence signal as the compound competes with the dye, which accumulates into lysosomes.</p> <p>Furthermore, <a href="https://admescope.com/services/permeability-and-transporters/#Efflux_Transporters" target="_blank" rel="noreferrer noopener">BSEP, MRP2 and MRP3 inhibition</a> and <a href="https://admescope.com/services/in-vitro-metabolism/#Reactive_Metabolites" target="_blank" rel="noreferrer noopener">reactive metabolite screening</a> can be included in the workflow to complement the data.</p> <p>Utilizing automated high-content imaging methods, the sensitive assays are coupled with rapid analysis and reliable readouts. <a href="https://admescope.com/contact-us/" target="_blank" rel="noreferrer noopener">Reach out to our team to discuss more</a>!</p> </div> <section class="bgimg background-image-block" style="background-image:url('https://admescope.com/wp-content/uploads/sites/2/2023/06/home-bgimg.jpg');"></section> <section class="block block"> <div class="block__content block__content--right"> <div class="block__text"> <h2>Feel free to contact us!</h2> <p><strong>Curious to know more about what can we do for you? 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name="email" type="email" placeholder="Email" required> </div> </div> <div class="form__row"> <div class="form__col"> <label for="agreement"> <input id="agreement" name="agreement" type="checkbox" required> <div>By downloading, I agree to the <a href='/privacy-policy/'>privacy policy</a></div> </label> </div> </div> <div class="form__row"> <div class="form__col"> <input type="text" name="downloaded_files" value="" style="opacity: 0;height: 0;overflow: hidden;"> <button type="submit" class="button button--primary">Download file(s)</button> <input type="hidden" name="action" value="symeresdownloads"> </div> </div> </form> </div> </section><script> jQuery( document ).ready(function() { jQuery(function ($) { let downloads = {}; $('body').on('click', '#downloads-close', function(){ $('.downloads__label').css('display', 'flex'); $('.downloads__content').css('display', 'none'); }); $('body').on('click', '.downloads__label', function(){ $('.downloads__label').css('display', 'none'); 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(localStorage.getItem('filenames')) { let currentFilenames = JSON.parse(localStorage.getItem('filenames')); filenames = { ...currentFilenames, ...filenames }; filenamesJson = JSON.stringify(filenames); } localStorage.setItem('filenames', filenamesJson); } if (Object.keys(downloads).length) { $('.downloads__aside').css('display', 'block'); let downloadsJson = JSON.stringify(downloads); if (localStorage.getItem('downloads')) { let currentDownloads = JSON.parse(localStorage.getItem('downloads')); downloads = { ...currentDownloads, ...downloads }; downloadsJson = JSON.stringify(downloads); } localStorage.setItem('downloads', downloadsJson); } else { if (!localStorage.getItem('downloads')) { localStorage.removeItem('downloads'); } } Object.keys(downloads).forEach(key => { let label = $('.downloads li label[for="download-file-' + downloads[key] + '"]').text(); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloads).length); $('#selected-files ul').html(downloadsList); // if (Object.keys(downloads).length) { //if (localStorage.getItem('downloads')) { // $('.downloads__aside').css('display', 'block'); // } else { // $('.downloads__aside').css('display', 'none'); // } }); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); let downloadsList = ''; $("input[name='downloaded_files']").val(Object.values(downloadsFromLocalStorage).join(',')); Object.keys(downloadsFromLocalStorage).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsFromLocalStorage[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsFromLocalStorage).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } else { $('.downloads__aside').css('display', 'none'); } $('body').on('click', '#remove-all-files', function(){ localStorage.removeItem('downloads'); $('#selected-files div ul li').remove(); $('.downloads__aside').css('display', 'none'); location.reload(); }); $('body').on('click', '#selected-files button', function(){ $('form.downloads input[data-download=' + $(this).data('download') + ']').prop('checked', false).trigger('change'); if (localStorage.getItem('downloads')) { let downloadsLocalObj = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsLocalObj) { delete downloadsLocalObj[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsLocalObj)); //reload sidebar html let downloadsList = ''; Object.keys(downloadsLocalObj).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsLocalObj[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsLocalObj[key] in filenames) { label = filenames[downloadsLocalObj[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsLocalObj[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsLocalObj).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } } }); $('#symeresdownloads').on('submit', function (e) { e.preventDefault(); if (localStorage.getItem('downloads')) { downloads = JSON.parse(localStorage.getItem('downloads')); $("input[name='downloaded_files']").val(''); $("input[name='downloaded_files']").val(Object.values(downloads).join(',')); } var symeresdownloads = $('#symeresdownloads'); var email = $("#symeresdownloads :input[name='email']").val(); var firstName = $("#symeresdownloads :input[name='first-name']").val(); var lastName = $("#symeresdownloads :input[name='last-name']").val(); var company = $("#symeresdownloads :input[name='company']").val(); var action = $("#symeresdownloads :input[name='action']").val(); downloads['email'] = email; downloads['first-name'] = firstName; downloads['last-name'] = lastName; downloads['company'] = company; downloads['action'] = action; runAjaxCall(symeresdownloads, downloads); // Clean up the downloads object delete downloads['email']; delete downloads['first-name']; delete downloads['last-name']; delete downloads['company']; delete downloads['action']; e.preventDefault(); }); function runAjaxCall(symeresdownloads, downloads) { var array = Object.keys(downloads).map((key) => [String(key), downloads[key]]); $.ajax({ url: symeresdownloads.attr('action'), data: downloads, // form data type: symeresdownloads.attr('method'), // POST beforeSend: function (xhr) { jQuery('#symeresdownloads button').hide(); jQuery('<p class="download-status">Your file(s) are being processed.</p>').insertAfter('#symeresdownloads button'); }, success: function (data) { let error = false; if (data.includes('address') || data.includes('download')) { if (!data.includes('Thank you')) { error = true; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } } if (data.includes('Thank you')) { error = false; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } setTimeout(function(){ 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