2024年北京质谱沙龙之高难度生物分析专场

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class="crumbs"> <a href="//www.antpedia.com" target="_blank" title="分析测试百科网">分析测试百科网</a> <em>></em> <a href="https://www.antpedia.com/news/" target="_blank" title="行业资讯">行业资讯</a> <em>></em> <a href="https://www.antpedia.com/news/725"><span>会议会展</span></a> </div> <div class="centerSide"> <h1 class="articleTitle">2024年北京质谱沙龙之高难度生物分析专场</h1> <div class="articleModule"> <div class="message details-message"> <div class="time">2024.12.08</div> <div class="visit" id="visit"></div> </div> <div class="articleContent"> <p>　　2024年12月6日至7日，由北京药学会主办，北京药学会临床研究与转化专委会承办，中日友好医院、首都医科大学附属北京安定医院、北京中关村生物医药创新协会、中国优生优育协会精准检验工作委员会、北京医学奖励基金会和分析测试百科网（安特百科（北京）技术发展有限公司）协办的2024年“质谱沙龙”学术交流年会（继教编号：2024-13-01-024）在北京举办。</p><p>　　会议次日下午的质谱沙龙之高难度生物分析专场由赛默飞世尔科技(中国)有限公司冠名赞助，中国农业大学系主任王战辉教授、北京协和医院郑昕副研究员、大连理工大学史美云副教授、爱思益普生物副总裁李黎博士、武汉宏韧生物技术总监陈桂英博士等五位专家进行报告分享，北京安定医院李鹏飞主任、北京安定医院副主任药师鲍爽主持会议。</p><p>　　<span style="color:rgb(0,112,192);"><strong>质谱沙龙之高难度生物分析专场</strong></span></p><p style="text-align:center;"><img src="https://i3.antpedia.com/attachments/2024/12/443248_202412090322141.jpg" alt="443248_202412090322141.jpg"></p><p style="text-align:center;"><img src="https://i3.antpedia.com/attachments/2024/12/443248_202412090324011.jpg" alt="443248_202412090324011.jpg"></p><p style="text-align:center;"><span style="font-family:'黑体', SimHei;">会议现场</span></p><p style="text-align:center;"><span style="font-family:'黑体', SimHei;"><img src="https://i3.antpedia.com/attachments/2024/12/443248_202412090324221.jpg" alt="443248_202412090324221.jpg"></span></p><p style="text-align:center;"><span style="font-family:'黑体', SimHei;">北京安定医院李鹏飞主任、北京安定医院副主任药师鲍爽主持会议</span></p><p>　　<span style="color:rgb(0,112,192);"><strong>专场报告</strong></span></p><p style="text-align:center;"><span style="color:rgb(0,112,192);"><strong><img src="https://i3.antpedia.com/attachments/2024/12/443248_202412090324301.jpg" alt="443248_202412090324301.jpg"></strong></span></p><p style="text-align:center;"><span style="font-family:'黑体', SimHei;">报告人：中国农业大学系主任王战辉教授</span></p><p style="text-align:center;"><span style="font-family:'黑体', SimHei;">报告题目：小分子化合物抗体精准创制及免疫分析检测技术研究</span></p><p>　　王战辉教授在报告中深入探讨了小分子化合物抗体的精准创制及其在免疫分析检测技术中的应用研究。王教授详细介绍了兽药、抗菌药物在食品安全检测中的重要性，并强调了快速检测技术在抗菌肉蛋奶中抗菌药物残留检测的关键作用。团队采用免疫分析和质谱方法进行国家标准的制定和检测，同时在食品安全领域，特别是在抗菌药物、生物毒素和非法添加物的检测方面取得了显著成果。王教授还分享了他们在半抗原设计、单克隆抗体制备以及新型免疫分析方法开发方面的进展。报告最后，他强调了跨学科合作在解决食品安全问题中的重要性，并展示了中国农业大学在这一领域的研究成果和未来发展方向。</p><p style="text-align:center;"><img src="https://i3.antpedia.com/attachments/2024/12/443248_202412090324391.jpg" alt="443248_202412090324391.jpg"></p><p style="text-align:center;"><span style="font-family:'黑体', SimHei;">报告人：北京协和医院郑昕副研究员</span></p><p style="text-align:center;"><span style="font-family:'黑体', SimHei;">报告题目：基于色谱分离联合EAD的磷脂酰胆碱异构体定性定量新策略</span></p><p>　　郑昕副研究员在报告中介绍了一种基于色谱分离联合电子激发解离（EAD）技术的磷脂酰胆碱异构体定性定量新策略。她详细阐述了脂质异构体在非酒精性脂肪性肝病和糖尿病等疾病中的不同生理功能，以及当前脂质C=C位置异构体分析的主要方法，包括衍生化法和气相离子活化/解离法。她强调了液相色谱-串联质谱在脂质异构体分析中的重要性，并提出了一种结合色谱分离和EAD技术的新方法，该方法能够在不需要衍生化的情况下，通过EAD技术精确分析脂质的精细结构。她还展示了该技术在实际人血浆样本中的应用，包括鉴别PC异构体的双键位置和立体异构，以及在尘肺病研究中的应用潜力。</p><p style="text-align:center;"><img src="https://i3.antpedia.com/attachments/2024/12/443248_202412090324481.jpg" alt="443248_202412090324481.jpg"></p><p style="text-align:center;"><span style="font-family:'黑体', SimHei;">报告人：大连理工大学史美云副教授</span></p><p style="text-align:center;"><span style="font-family:'黑体', SimHei;">报告题目：基于质谱技术的小分子药物、多肽药物及聚合物药用辅料的分析方法开发</span></p><p>　　史美云副教授在报告中探讨了基于质谱技术的小分子药物、多肽药物及聚合物药用辅料的分析方法开发。她详细介绍了结合雌激素药物的精准分析方法及其在女性不同生理时期的应用，包括雌酮、雌二醇和雌三醇的定量分析，以及结合雌激素片剂的药代动力学研究。她提出了结合雌激素定量分析的挑战和解决方案，包括样品前处理的优化和平行柱切换系统的开发。此外，还讨论了绿色分析化学的概念，介绍了绿色度评价算法GEMAM的开发及其在分析方法和软件中的应用。</p><p style="text-align:center;"><img src="https://i3.antpedia.com/attachments/2024/12/443248_202412090324571.jpg" alt="443248_202412090324571.jpg"></p><p style="text-align:center;"><span style="font-family:'黑体', SimHei;">报告人：爱思益普生物副总裁李黎博士</span></p><p style="text-align:center;"><span style="font-family:'黑体', SimHei;">报告题目：液相色谱质谱技术在ADC药物研发中的应用</span></p><p>　　李黎在报告中深入探讨了液相色谱质谱技术在抗体药物偶联物（ADC）研发中的应用。首先介绍了ADC药物的基本组成和作用机制，包括靶点、抗体、连接子和毒素，并汇总了已上市的ADC药物。她强调了ADC药物研发的目的，即通过抗体的长半衰期、高效药物缓释、抗体靶向递送和降低起效剂量来扩大治疗窗。报告中，她详细讨论了LC-MS技术在ADC研发中的关键应用，包括生物样品分析和质量分析，并比较了配体结合分析和质谱分析平台的优劣。她还关注了血浆/血清中ADC药物偶联药物（DAR）的重要性，并展示了LC-HRMS分析血浆中ADC DAR的案例，以及IC-LC-MS/MS法检测血清中偶联药物的原理和案例分析。</p><p style="text-align:center;"><img src="https://i3.antpedia.com/attachments/2024/12/443248_202412090325071.jpg" alt="443248_202412090325071.jpg"></p><p style="text-align:center;"><span style="font-family:'黑体', SimHei;">报告人：武汉宏韧生物技术总监陈桂英博士</span></p><p style="text-align:center;"><span style="font-family:'黑体', 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